Administration of eplerenone with other CYP3A4 inhibitors (e.g., erythromycin 500 mg BID, verapamil 240 mg QD, saquinavir 1200 mg TID, fluconazole 200 mg QD) resulted in increases in Cmax of eplerenone ranging from 1.4- to 1.6- fold and AUC from 2.0- to 2.9- fold.
<eplerenone, mechanism, erythromycin>, <eplerenone, mechanism, verapamil>, <eplerenone, mechanism, saquinavir>, <eplerenone, mechanism, fluconazole>