Therefore, CYP3A4 substrates known to have a narrow therapeutic index such as alfentanil, astemizole, terfenadine, cisapride, cyclosporine, fentanyl, pimozide, quinidine, sirolimus, tacrolimus, or ergot alkaloids (ergotamine, dihydroergotamine) should be administered with caution in patients receiving SPRYCEL.
<alfentanil, advise, SPRYCEL>, <astemizole, advise, SPRYCEL>, <terfenadine, advise, SPRYCEL>, <cisapride, advise, SPRYCEL>, <cyclosporine, advise, SPRYCEL>, <fentanyl, advise, SPRYCEL>, <pimozide, advise, SPRYCEL>, <quinidine, advise, SPRYCEL>, <sirolimus, advise, SPRYCEL>, <tacrolimus, advise, SPRYCEL>, <ergot alkaloids, advise, SPRYCEL>, <ergotamine, advise, SPRYCEL>, <dihydroergotamine, advise, SPRYCEL>