Also, due to the potential for additive effects such as bradycardia and AV block, caution is warranted in patients receiving clonidine with agents known to affect sinus node function or AV nodal conduction (e.g., digitalis, calcium channel blockers, and beta-blockers.)
<clonidine, advise, digitalis>, <clonidine, advise, calcium channel blockers>, <clonidine, advise, beta-blockers>