Hepatic Enzyme Inducers, Inhibitors and Substrates: Drugs which induce cytochrome P450 3A4 (CYP 3A4) enzyme activity (e.g., barbiturates, phenytoin, carbamazepine, rifampin) may enhance the metabolism of corticosteroids and require that the dosage of the corticosteroid be increased.
<barbiturates, mechanism, corticosteroids>, <phenytoin, mechanism, corticosteroids>, <carbamazepine, mechanism, corticosteroids>, <rifampin, mechanism, corticosteroids>