Since PLETAL is extensively metabolized by cytochrome P-450 isoenzymes, caution should be exercised when PLETAL is coadministered with inhibitors of C.P.A. such as ketoconazole and erythromycin or inhibitors of CYP2C19 such as omeprazole.
<PLETAL, advise, ketoconazole>, <PLETAL, advise, erythromycin>, <PLETAL, advise, omeprazole>