On the basis of the metabolism of bexarotene by cytochrome P450 3A4, ketoconazole, itraconazole, erythromycin, gemfibrozil, grapefruit juice, and other inhibitors of cytochrome P450 3A4 would be expected to lead to an increase in plasma bexarotene concentrations.
<ketoconazole, mechanism, bexarotene>, <itraconazole, mechanism, bexarotene>, <erythromycin, mechanism, bexarotene>, <gemfibrozil, mechanism, bexarotene>