Central Nervous System Depressants: The concomitant use of DURAGESIC  (fentanyl transdermal system) with other central nervous system depressants, including but not limited to other opioids, sedatives, hypnotics, tranquilizers (e.g., benzodiazepines), general anesthetics, phenothiazines, skeletal muscle relaxants, and alcohol, may cause respiratory depression, hypotension, and profound sedation, or potentially result in coma or death.
<DURAGESIC, effect, central nervous system depressants>, <DURAGESIC, effect, opioids>, <DURAGESIC, effect, sedatives>, <DURAGESIC, effect, hypnotics>, <DURAGESIC, effect, tranquilizers>, <DURAGESIC, effect, benzodiazepines>, <DURAGESIC, effect, anesthetics>, <DURAGESIC, effect, phenothiazines>, <DURAGESIC, effect, skeletal muscle relaxants>, <DURAGESIC, effect, alcohol>, <fentanyl, effect, central nervous system depressants>, <fentanyl, effect, opioids>, <fentanyl, effect, sedatives>, <fentanyl, effect, hypnotics>, <fentanyl, effect, tranquilizers>, <fentanyl, effect, benzodiazepines>, <fentanyl, effect, anesthetics>, <fentanyl, effect, phenothiazines>, <fentanyl, effect, skeletal muscle relaxants>, <fentanyl, effect, alcohol>