The plasma concentration of imipramine may increase when the drug is given concomitantly with hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decrease by concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and adjustment of the dosage of imipramine may therefore be necessary.
<imipramine, mechanism, cimetidine>, <imipramine, mechanism, fluoxetine>, <imipramine, mechanism, barbiturates>, <imipramine, mechanism, phenytoin>