Quinidine, verapamil, amiodarone, propafenone, indomethacin, itraconazole, alprazolam, and spironolactone raise the serum digoxin concentration due to a reduction in clearance and/or in volume of distribution of the drug, with the implication that digitalis intoxication may result.
<Quinidine, mechanism, digoxin>, <verapamil, mechanism, digoxin>, <amiodarone, mechanism, digoxin>, <propafenone, mechanism, digoxin>, <indomethacin, mechanism, digoxin>, <itraconazole, mechanism, digoxin>, <alprazolam, mechanism, digoxin>, <spironolactone, mechanism, digoxin>