Valdecoxib caused a statistically significant increase in plasma exposures of R-warfarin and S-warfarin (12% and 15%, respectively), and in the pharmacodynamic effects (prothrombin time, measured as INR) of warfarin.
<Valdecoxib, mechanism, R-warfarin>, <Valdecoxib, mechanism, S-warfarin>, <Valdecoxib, effect, warfarin>