---
license: mit
configs:
- config_name: dataset
  data_files: "dataset.csv"
---

### Description
This dataset contains 160000 sequences of four site mutation of an enzyme active site. 
The enzyme is β-subunit of tryptophan synthase (TrpB), which synthesizes L-tryptophan (Trp) from indole and L-serine (Ser).
The parent enzyme is TrpB variant Tm9D8*.
Tm9D8* differs from wildtype TmTrpB by ten amino acid substitutions (P19G, E30G, I69V, K96L, P140L, N167D, I184F, L213P, G228S, and T292S).
The 4-sitesaturation library targeted two pairs of positions: 183/184 and 227/228.

**Protein Format:** AA sequence

### Splits
traing: 128000

valid: 16000

test: 16000

### Related paper 
The dataset is from [A combinatorially complete epistatic fitness landscape in an enzyme active site](https://www.biorxiv.org/content/10.1101/2024.06.23.600144v1).

### Label
Label means mutation fitness, here represents growth rate of E. coli strain. The maximum fitness of this landscape is 1, the closer to 1, the better fitness.