title: Étude de la colonisation fongique chez les patients adultes atteints de mucoviscidose au CHU de Rouen entre 2005 et 2010. Sciences pharmaceutiques. 2012. &#x27E8;dumas-00704396&#x27E9;
text: Étude de la colonisation fongique chez les patients
  adultes atteints de mucoviscidose au CHU de Rouen
  entre 2005 et 2010
  Marine Gallo
  
  To cite this version:
  Marine Gallo. Étude de la colonisation fongique chez les patients adultes atteints de mucoviscidose
  au CHU de Rouen entre 2005 et 2010. Sciences pharmaceutiques. 2012. �dumas-00704396�
  
  HAL Id: dumas-00704396
  https://dumas.ccsd.cnrs.fr/dumas-00704396
  Submitted on 5 Jun 2012
  
  HAL is a multi-disciplinary open access
  archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from
  teaching and research institutions in France or
  abroad, or from public or private research centers.
  L’archive ouverte pluridisciplinaire HAL, est
  destinée au dépôt et à la diffusion de documents
  scientifiques de niveau recherche, publiés ou non,
  émanant des établissements d’enseignement et de
  recherche français ou étrangers, des laboratoires
  publics ou privés.
   !"#"$"%&'%('&')*+'%',%&'%-./$(/)*'%%
  &'%$0!'+%
  %
  %
  1231%
  
  +4%
  
  %
  
  !"#$#%&'()%*#%%
  +,&*-.#%+/#!0!%+#%+'1!#()%
  #2%&"0).01,#%
  %
  5/660%(789:;%
  +<;%=;%>%/?89=%3@A>%B%C9D8E%FG8%H;9:;%
  %
  -8<F;:D<;%;D%FIGD;:G;%JGK=9LG;M;:D%=;%3A%/?89=%1231%
  %
  
  #!(+#%+#%*0%1'*'2,$0!,'2%3'24,5(#%1"#6%*#$%&0!,#2!$%
  0+(*!#$%0!!#,2!$%+#%.(1'7,$1,+'$#%0(%1"(%+#%)'(#2%#2!)#%
  899:%#!%89;9%
  %
  %
  -8<F9N;:D%NG%OG8E%P%("%#/C'++')%6IQRS%-!T-.%
  (;MK8;F%NG%OG8E%P%("%5/$5/6/%59==;FS%()!T-.%
  ("%&0(*+*U!'%HD<JV7:;S%-.S%&8%;:%M<N;R9:;%
  ("%6'(''%6GNI?9RS%-.S%&8%;:%JV78M7R9;%
  
  )#.#)1,#.#2!$%%
  %
  W;%D9;:F%B%8;M;8R9;8%=;%-8IX;FF;G8%6IQR%#7?;::;RS%RV;X%NG%N<J78D;M;:D%N;%-787F9DI=IY9;T
  (ERI=IY9;%NG%).!%N;%$IG;:S%JIG8%MZ7?I98%J8IJIF<%R;%FGO;D%NZ7RDG7=9D<%F9%9:D<8;FF7:D%F9DG<%
  7G% R[G8% N;% =7% 8;RV;8RV;% MERI=IY9LG;% N7:F% =;% R7N8;% N;% =7% MGRI?9FR9NIF;"% W;% =;% 8;M;8R9;%
  NZ7?I98% N989Y<% R;DD;% DV\F;% 7?;R% D7:D% NZ9:D;8]DS% JIG8% =;% D;MJF% LGZ9=% MZ7% RI:F7R8<% 79:F9% LG;%
  JIG8%F;F%J8<R9;G^%RI:F;9=F"%(;8R9%JIG8%F7%8;=;RDG8;%;D%F;F%RI88;RD9I:F"%%
  %
  W;% 8;M;8R9;% <Y7=;M;:D% =;% &IRD;G8% HD<JV7:;% &IM9:9LG;S% J:;GMI=IYG;% 7G% ).!% N;%
  $IG;:S% N;% MZ7?I98% 8;_G;% ;D% YG9N<;% N7:F% M;F% 8;RV;8RV;F% 79:F9% LG;% JIG8% F;F% RI88;RD9I:F"%
  (;8R9%NZ7?I98%7RR;JD<%NZ]D8;%J8<F;:D%;:%D7:D%LG;%M;MK8;%NG%OG8E"%%
  %
  W;%8;M;8R9;%=;%&IRD;G8%59==;F%578Y7=7S%MERI=IYG;%7G%).!%N;%$IG;:S%NZ7?I98%7RR;JD<%N;%
  OGY;8%MI:%D87?79="%
  %
  W;% 8;M;8R9;% =;% &IRD;G8% 6GNI?9R% 6;M<;S% K7RD<89I=IY9FD;% 7G% ).!% N;% $IG;:S% JIG8% F7%
  8;=;RDG8;%;D%JIG8%F7%J8<F;:R;%;:%D7:D%LG;%M;MK8;%NG%OG8E"%
  %
  
  %
  (;8R9%B%DIGD;%=Z<LG9J;%NG%=7KI87DI98;%N;%-787F9DI=IY9;T(ERI=IY9;%JIG8%FI:%7RRG;9=%=I8F%
  
  N;% MI:% FD7Y;% VIFJ9D7=ITG:9?;8F9D798;% N;% `\M;% 7::<;% ;D% JIG8% FI:% 79N;% RI:R;8:7:D%
  =Z7RLG9F9D9I:%N;F%NI::<;F%:<R;FF798;F%B%MI:%D87?79="%
  %
  (;8R9%7G^%9:X98M9\8;F%NG%)$)(%N;%$IG;:%JIG8%=;G8%7RRG;9=%;D%=;G8%N9FJI:9K9=9D<"%
  %
  ':X9:%O;%8;M;8R9;%M7%X7M9==;S%M;F%7M9F%;D%/=;^9F%N;%MZ7?I98%7RRIMJ7Y:<;%;D%FIGD;:G;%
  NG87:D%M;F%7::<;F%NZ<DGN;F"%%
  
  %
  %
  %
  %
  
  ANNEE UNIVERSITAIRE 2011 - 2012
  
  U.F.R. DE MEDECINE-PHARMACIE DE ROUEN
  DOYEN :
  
  Professeur Pierre FREGER
  
  ASSESSEURS :
  
  Professeur Michel GUERBET
  Professeur Benoit VEBER
  Professeur Pascal JOLY
  Professeur Bernard PROUST
  
  DOYENS HONORAIRES :
  
  Professeurs J. BORDE - Ph. LAURET - H. PIGUET - C. THUILLEZ
  
  PROFESSEURS
  HONORAIRES :
  
  MM. M-P AUGUSTIN - J.ANDRIEU-GUITRANCOURT - M.BENOZIOJ.BORDE - Ph. BRASSEUR - R. COLIN - E. COMOY - J. DALION -.
  DESHAYES C. FESSARD - J.P FILLASTRE - P.FRIGOT -J. GARNIER - J.
  HEMET - B. HILLEMAND - G. HUMBERT - J.M. JOUANY - R.
  LAUMONIER - Ph. LAURET - M. LE FUR - J.P. LEMERCIER - J.P
  LEMOINE - Mle MAGARD - MM. B. MAITROT - M. MAISONNET F. MATRAY - P.MITROFANOFF - Mme A. M. ORECCHIONI - P.
  PASQUIS - H.PIGUET - M.SAMSON - Mme SAMSON-DOLLFUS - J.C.
  SCHRUB - R.SOYER - B.TARDIF -.TESTART - J.M. THOMINE - C.
   THUILLEZ - P.TRON - C.WINCKLER - L.M.WOLF
  I - MEDECINE
  
  PROFESSEURS
  M. Frédéric ANSELME
  
  HCN
  
  Cardiologie
  
  M. Bruno BACHY
  
  HCN
  
  Chirurgie pédiatrique
  
  M. Fabrice BAUER
  
  HCN
  
  Cardiologie
  
  Mme Soumeya BEKRI
  
  HCN
  
  Biochimie et Biologie Moléculaire
  
  M. Jacques BENICHOU
  médicale
  
  HCN
  
  Biostatistiques
  
  M. Eric BERCOFF
  
  HB
  
  Médecine interne (gériatrie)
  
  M. Jean-Paul BESSOU
  vasculaire
  
  HCN
  
  Chirurgie
  
  Mme Françoise BEURET-BLANQUART
  
  CRMPR
  
  Médecine physique et de réadaptation
  
  M. Guy BONMARCHAND
  
  HCN
  
  Réanimation médicale
  
  M. Olivier BOYER
  
  UFR
  
  Immunologie
  
  M. Jean-François CAILLARD
  
  HCN
  
  Médecine et santé au Travail
  
  M. François CARON
  
  HCN
  
  Maladies infectieuses et tropicales
  
  M. Philippe CHASSAGNE
  
  HB
  
  Médecine interne (Gériatrie)
  
  M. Alain CRIBIER (Surnombre)
  
  HCN
  
  Cardiologie
  
  M. Antoine CUVELIER
  
  HB
  
  Pneumologie
  
  et
  
  thoracique
  
  informatique
  
  et
  
  cardio-
  
  M. Pierre CZERNICHOW
  
  HCH
  
  Epidémiologie, économie de la santé
  
  M. Jean - Nicolas DACHER
  
  HCN
  
  Radiologie et Imagerie Médicale
  
  M. Stéfan DARMONI
  
  HCN
  
  Informatique Médicale/Techniques de communication
  
  M. Pierre DECHELOTTE
  
  HCN
  
  Nutrition
  
  Mme Danièle DEHESDIN
  
  HCN
  
  Oto-Rhino-Laryngologie
  
  M. Philippe DENIS (Surnombre)
  
  HCN
  
  Physiologie
  
  M. Jean DOUCET
  
  HB
  
  Thérapeutique/Médecine - Interne - Gériatrie.
   M. Bernard DUBRAY
  
  CB
  
  Radiothérapie
  
  M. Philippe DUCROTTE
  
  HCN
  
  Hépato - Gastro - Entérologie
  
  M. Frank DUJARDIN
  
  HCN
  
  Chirurgie Orthopédique - Traumatologique
  
  M. Fabrice DUPARC
  
  HCN
  
  Anatomie Chirurgie Orthopédique et Traumatologique
  
  M. Bertrand DUREUIL
  
  HCN
  
  Anesthésiologie et réanimation chirurgicale
  
  Mle Hélène ELTCHANINOFF
  
  HCN
  
  Cardiologie
  
  M. Thierry FREBOURG
  
  UFR
  
  Génétique
  
  M. Pierre FREGER
  
  HCN
  
  Anatomie/Neurochirurgie
  
  M. Jean François GEHANNO
  
  HCN
  
  Médecine et Santé au Travail
  
  M. Emmanuel GERARDIN
  
  HCN
  
  Imagerie Médicale
  
  Mme Priscille GERARDIN
  
  HCN
  
  Pédopsychiatrie
  
  M. Michel GODIN
  
  HB
  
  Néphrologie
  
  M. Philippe GRISE
  
  HCN
  
  Urologie
  
  M. Didier HANNEQUIN
  
  HCN
  
  Neurologie
  
  M. Fabrice JARDIN
  
  CB
  
  Hématologie
  
  M. Luc-Marie JOLY
  
  HCN
  
  Médecine d’urgence
  
  M. Pascal JOLY
  
  HCN
  
  Dermato - vénéréologie
  
  M. Jean-Marc KUHN
  
  HB
  
  Endocrinologie et maladies métaboliques
  
  Mme Annie LAQUERRIERE
  
  HCN
  
  Anatomie cytologie pathologiques
  
  M. Vincent LAUDENBACH
  
  HCN
  
  Anesthésie et réanimation chirurgicale
  
  M. Alain LAVOINNE
  
  UFR
  
  Biochimie et biologie moléculaire
  
  M. Joël LECHEVALLIER
  
  HCN
  
  Chirurgie infantile
  
  M. Hervé LEFEBVRE
  
  HB
  
  Endocrinologie et maladies métaboliques
  
  M. Xavier LE LOET
  
  HB
  
  Rhumatologie
  
  M. Eric LEREBOURS
  
  HCN
  
  Nutrition
  
  Mle Anne-Marie LEROI
  
  HCN
  
  Physiologie
  
  M. Hervé LEVESQUE
  
  HB
  
  Médecine interne
  
  Mme Agnès LIARD-ZMUDA
  
  HCN
  
  Chirurgie Infantile
  
  M. Bertrand MACE
  
  HCN
  
  Histologie, embryologie, cytogénétique
  
  M. Eric MALLET (Surnombre)
  
  HCN
  
  Pédiatrie
  
  M. Christophe MARGUET
  
  HCN
  
  Pédiatrie
  
  Mle Isabelle MARIE
  
  HB
  
  Médecine Interne
  
  M. Jean-Paul MARIE
  
  HCN
  
  ORL
  
  M. Loïc MARPEAU
  
  HCN
  
  Gynécologie - obstétrique
  
  M. Stéphane MARRET
  
  HCN
  
  Pédiatrie
  
  M. Pierre MICHEL
  
  HCN
  
  Hépato - Gastro - Entérologie
  
  M. Francis MICHOT
  
  HCN
  
  Chirurgie digestive
  
  M. Bruno MIHOUT
  
  HCN
  
  Neurologie
  
  M. Pierre-Yves MILLIEZ
  
  HCN
  
  Chirurgie plastique, reconstructrice et esthétique
  
  M. Jean-François MUIR
  
  HB
  
  Pneumologie
  
  M. Marc MURAINE
  
  HCN
  
  Ophtalmologie
  
  M. Philippe MUSETTE
  
  HCN
  
  Dermatologie - Vénéréologie
  
  M. Christophe PEILLON
  
  HCN
  
  Chirurgie générale
  
  M. Jean-Marc PERON
  
  HCN
  
  Stomatologie et chirurgie maxillo-faciale
  
  M. Christian PFISTER
  
  HCN
  
  Urologie
  
  M. Jean-Christophe PLANTIER
  
  HCN
  
  Bactériologie - Virologie
  
  M. Didier PLISSONNIER
  
  HCN
  
  Chirurgie vasculaire
  
  M. Bernard PROUST
  
  HCN
  
  Médecine légale
  
  M. François PROUST
  
  HCN
  
  Neurochirurgie
  
  Mme Nathalie RIVES
  
  HCN
  
  Biologie et méd. du dévelop. et de la reprod.
   M. Jean-Christophe RICHARD (Mise en dispo) HCN
  
  Réanimation Médicale, Médecine d’urgence
  
  M. Horace ROMAN
  
  HCN
  
  Gynécologie Obstétrique
  
  M. Jean-Christophe SABOURIN
  
  HCN
  
  Anatomie - Pathologie
  
  M. Guillaume SAVOYE
  
  HCN
  
  Hépato - Gastro
  
  M. Michel SCOTTE
  
  HCN
  
  Chirurgie digestive
  
  Mme Fabienne TAMION
  
  HCN
  
  Thérapeutique
  
  Mle Florence THIBAUT
  
  HCN
  
  Psychiatrie d’adultes
  
  M. Luc THIBERVILLE
  
  HCN
  
  Pneumologie
  
  M. Christian THUILLEZ
  
  HB
  
  Pharmacologie
  
  M. Hervé TILLY
  
  CB
  
  Hématologie et transfusion
  
  M. François TRON (Surnombre)
  
  UFR
  
  Immunologie
  
  M. Jean-Jacques TUECH
  
  HCN
  
  Chirurgie digestive
  
  M. Jean-Pierre VANNIER
  
  HCN
  
  Pédiatrie génétique
  
  M. Benoît VEBER
  
  HCN
  
  Anesthésiologie Réanimation chirurgicale
  
  M. Pierre VERA
  
  C.B
  
  Biophysique et traitement de l’image
  
  M. Eric VERSPYCK
  
  HCN
  
  Gynécologie obstétrique
  
  M. Olivier VITTECOQ
  
  HB
  
  Rhumatologie
  
  M. Jacques WEBER
  
  HCN
  
  Physiologie
  
  Mme Noëlle BARBIER-FREBOURG
  
  HCN
  
  Bactériologie - Virologie
  
  M. Jeremy BELLIEN
  
  HCN
  
  Pharmacologie
  
  Mme Carole BRASSE LAGNEL
  
  HCN
  
  Biochimie
  
  Mme Mireille CASTANET
  
  HCN
  
  Pédiatrie
  
  M. Gérard BUCHONNET
  
  HCN
  
  Hématologie
  
  Mme Nathalie CHASTAN
  
  HCN
  
  Physiologie
  
  Mme Sophie CLAEYSSENS
  
  HCN
  
  Biochimie et biologie moléculaire
  
  M. Moïse COEFFIER
  
  HCN
  
  Nutrition
  
  M. Vincent COMPERE
  
  HCN
  
  Anesthésiologie et réanimation chirurgicale
  
  M. Manuel ETIENNE
  
  HCN
  
  Maladies infectieuses et tropicales
  
  M. Guillaume GOURCEROL
  
  HCN
  
  Physiologie
  
  Mme Catherine HAAS-HUBSCHER
  
  HCN
  
  Anesthésie - Réanimation chirurgicale
  
  M. Serge JACQUOT
  
  UFR
  
  Immunologie
  
  M. Joël LADNER
  
  HCN
  
  Epidémiologie, économie de la santé
  
  M. Jean-Baptiste LATOUCHE
  
  UFR
  
  Biologie Cellulaire
  
  Mme Lucie MARECHAL-GUYANT
  
  HCN
  
  Neurologie
  
  M. Jean-François MENARD
  
  HCN
  
  Biophysique
  
  Mme Muriel QUILLARD
  
  HCN
  
  Biochimie et Biologie moléculaire
  
  M. Vincent RICHARD
  
  UFR
  
  Pharmacologie
  
  M. Francis ROUSSEL
  
  HCN
  
  Histologie, embryologie, cytogénétique
  
  Mme Pascale SAUGIER-VEBER
  
  HCN
  
  Génétique
  
  Mme Anne-Claire TOBENAS-DUJARDIN HCN
  
  Anatomie
  
  M. Eric VERIN
  
  Physiologie
  
  MAITRES DE CONFERENCES
  
  HCN
  
  MAITRE DE CONFERENCES ASSOCIE A MI-TEMPS
  M. Thierry LEQUERRE
  
  HB
  
  Rhumatologie
  
  M. Fabien DOGUET
  
  HCN
  
  Chirurgie thoracique et cardio-vasculaire
  
  PROFESSEUR AGREGE OU CERTIFIE
  
  Mme Dominique LANIEZ
  
  UFR
  
  Anglais
  
  Mme Michèle GUIGOT
  
  UFR
  
  Sciences humaines - Techniques d’expression
  
  II - PHARMACIE
  PROFESSEURS
  M. Thierry BESSON
  
  Chimie Thérapeutique
  
  M. Jean-Jacques BONNET
  
  Pharmacologie
  
  M. Roland CAPRON (PU-PH)
  
  Biophysique
  
  M. Jean COSTENTIN (PU-PH)
  
  Pharmacologie
  
  Mme Isabelle DUBUS
  
  Biochimie
  
  M. Loïc FAVENNEC (PU-PH)
  
  Parasitologie
  
  M. Michel GUERBET
  
  Toxicologie
  
  M. Olivier LAFONT
  
  Chimie organique
  
  Mme Isabelle LEROUX
  
  Physiologie
  
  Mme Elisabeth SEGUIN
  
  Pharmacognosie
  
  M. Marc VASSE (PU-PH)
  
  Hématologie
  
  M Jean-Marie VAUGEOIS (Délégation
  
  Pharmacologie
  
  CNRS) M. Philippe VERITE
  
  Chimie analytique
  
  MAITRES DE CONFERENCES
  Mle Cécile BARBOT
  
  Chimie Générale et Minérale
  
  Mme Dominique BOUCHER
  
  Pharmacologie
  
  M. Frédéric BOUNOURE
  
  Pharmacie Galénique
  
  Mme Martine PESTEL-CARON
  
  Microbiologie
  
  M. Abdeslam CHAGRAOUI
  
  Physiologie
  
  M.  Jean CHASTANG
  
  Biomathématiques
  
  Mme
  
  Marie
  
  Catherine
  
  CONCE-
  
  Législation pharmaceutique et économie de la santé
  
  CHEMTOB
  Mme Elizabeth CHOSSON
  
  Botanique
  
  Mle Cécile CORBIERE
  
  Biochimie
  
  M. Eric DITTMAR
  
  Biophysique
  
  Mme Nathalie DOURMAP
  
  Pharmacologie
  
  Mle Isabelle DUBUC
  
  Pharmacologie
  
  Mme Roseline DUCLOS
  
  Pharmacie Galénique
  
  M. Abdelhakim ELOMRI
  
  Pharmacognosie
  
  M. François ESTOUR
  
  Chimie Organique
  
  M. Gilles GARGALA (MCU-PH)
  
  Parasitologie
  
  Mme Najla GHARBI
  
  Chimie analytique
  
  Mle Marie-Laure GROULT
  
  Botanique
  
  M. Hervé HUE
  
  Biophysique et Mathématiques
  
  Mme Hong LU
  
  Biologie
  
  Mme Sabine MENAGER
  
  Chimie organique
  
  Mme Christelle MONTEIL
  
  Toxicologie
  
  M. Paul MULDER
  
  Sciences du médicament
  
  M. Mohamed SKIBA
  
  Pharmacie Galénique
  
  Mme Malika SKIBA
  
  Pharmacie Galénique
  
  Mme Christine THARASSE
  
  Chimie thérapeutique
  
  M. Rémi VARIN (MCU-PH)
  
  Pharmacie Hospitalière
  
  M. Frédéric ZIEGLER
  
  Biochimie
  
  PROFESSEUR ASSOCIE
  M. Jean-Pierre GOULLE
  
  Toxicologie
  
  MAITRE DE CONFERENCE ASSOCIE
  Mme Sandrine PANCHOU
  
  Pharmacie Officinale
  
  PROFESSEUR AGREGE OU CERTIFIE
  Mme Anne-Marie ANZELLOTTI
  
  Anglais
  
  ATTACHE TEMPORAIRE D’ENSEIGNEMENT ET DE RECHERCHE
  M. Bérénice COQUEREL
  
  Chimie Analytique
  
  M. Johann PELTIER
  
  Microbiologie
  
  CHEF DES SERVICES ADMINISTRATIFS : Mme Véronique DELAFONTAINE
  HCN - Hôpital Charles Nicolle
  
  HB - Hôpital de BOIS GUILLAUME
  
  CB - Centre HENRI BECQUEREL
  CHS - Centre Hospitalier Spécialisé du Rouvray
  CRMPR - Centre Régional de Médecine Physique et de Réadaptation
  
  III - MEDECINE GENERALE
  
  PROFESSEURS
  M. Jean-Loup HERMIL
  
  UFR
  
  Médecine générale
  
  M. Pierre FAINSILBER
  
  UFR
  
  Médecine générale
  
  M. Alain MERCIER
  
  UFR
  
  Médecine générale
  
  M. Philippe NGUYEN THANH
  
  UFR
  
  Médecine générale
  
  PROFESSEURS ASSOCIES A MI-TEMPS :
  
  MAITRE DE CONFERENCES ASSOCIE A MI-TEMPS :
  M Emmanuel LEFEBVRE
  
  UFR
  
  Médecine générale
  
  Mme Elisabeth MAUVIARD
  
  UFR
  
  Médecine générale
  
  Mme Marie Thérèse THUEUX
  
  UFR
  
  Médecine générale
  
  LISTE DES RESPONSABLES DE DISCIPLINE
  
  Melle Cécile BARBOT
  
  Chimie Générale et Minérale
  
  M. Thierry BESSON
  
  Chimie thérapeutique
  
  M. Roland CAPRON
  
  Biophysique
  
  M Jean CHASTANG
  
  Mathématiques
  
  Mme Marie-Catherine CONCE-CHEMTOB
  
  Législation, Economie de la Santé
  
  Mle Elisabeth CHOSSON
  
  Botanique
  
  M. Jean COSTENTIN
  
  Pharmacodynamie
  
  Mme Isabelle DUBUS
  
  Biochimie
  
  M. Loïc FAVENNEC
  
  Parasitologie
  
  M. Michel GUERBET
  
  Toxicologie
  
  M. Olivier LAFONT
  
  Chimie organique
  
  M. Jean-Louis PONS
  
  Microbiologie
  
  Mme Elisabeth SEGUIN
  
  Pharmacognosie
  
  M. Mohamed SKIBA
  
  Pharmacie Galénique
  
  M. Marc VASSE
  
  Hématologie
  
  M. Philippe VERITE
  
  Chimie analytique
  
  ENSEIGNANTS MONO-APPARTENANTS
  
  MAITRES DE CONFERENCES
  M. Sahil ADRIOUCH
  
  Biochimie et biologie moléculaire
  (Unité Inserm 905)
  
  Mme Gaëlle BOUGEARD-DENOYELLE
  
  Biochimie et biologie moléculaire
  (Unité Inserm 614)
  
  M. Antoine OUVRARD-PASCAUD
  
  Physiologie (Unité Inserm 644)
  
  PROFESSEURS DES UNIVERSITES
  
  M. Mario TOSI
  
  Biochimie et biologie moléculaire
  (Unité Inserm 614)
  
  M.  Serguei FETISSOV Physiologie (Groupe ADEN) Mme Su RUAN % % % % % 31% % % % % % % % % % -78%N<=9K<87D9I:%;:%N7D;%NG%2a%(78F%3@b>S%=7%X7RG=D<%7%788]D<%LG;%=;F%IJ9:9I:F%<M9F;F%N7:F% =;F%N9FF;8D7D9I:F%LG9%=G9%F;8I:D%J8<F;:D<;F%NI9?;:D%]D8;%RI:F9N<8<;F%RIMM;%J8IJ8;F%B%=;G8F% 7GD;G8F%;D%LGZ;==;%:Z;:D;:N%=;G8%NI::;8%7GRG:;%7JJ8IK7D9I:%:9%9MJ8IK7D9I:"% % % 3a% !0<*#%+#$%.0!,#)#$% ;% ,2!)'+(1!,'2%===========================================================================================================%89% 8% 4#2#)0*,!#$%===============================================================================================================%8;% 8=;% *>%?@ABCDEADFBEG%=====================================================================================================%8;% 1"3"3% 'J9N<M9I=IY9;%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%13% 1"3"1% -VEF9IJ7DVI=IY9;%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%11% 1"3"1"3% 67%J8ID<9:;%)#,$%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%11% 1"3"1"1% )I:F<LG;:R;F%N;%=7%MGD7D9I:%B%=ZI89Y9:;%N;%=7%MGRI?9FR9NIF;%""""""""""""""""""""""""""%1`% 1"3"1"a% )I88<=7D9I:%;:D8;%=7%MGD7D9I:%NG%Y\:;%;D%=7%XI:RD9I:%N;%=7%J8ID<9:;%)#,$%""""""""%1`% 1"3"1"c% $;=7D9I:F%Y<:IDEJ;dJV<:IDEJ;%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%1b% 1"3"a% &97Y:IFD9R%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%1A% 1"3"a"3% 6;%&97Y:IFD9R%+<I:7D7=%N;%=7%(GRI?9FR9NIF;%IG%&+(%"""""""""""""""""""""""""""""""""""""""%1A% 1"3"a"1% 67%8;RV;8RV;%N;F%MGD7D9I:F%NG%Y\:;%)#,$%""""""""""""""""""""""""""""""""""""""""""""""""""""""""%1@% 1"3"a"a% ,;FD%B%=7%FG;G8%e,Hf%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%a2% 1"3"c% )=9:9LG;%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%a2% 1"3"c"3% /DD;9:D;F%8;FJ987DI98;F%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%a2% 1"3"c"3"3% (7:9X;FD7D9I:%R=9:9LG;%RV;g%=;%J;D9D%;:X7:D%"""""""""""""""""""""""""""""""""""""""""""""""""%a3% 1"3"c"3"1% '?I=GD9I:%N;F%M7:9X;FD7D9I:F%8;FJ987DI98;F%""""""""""""""""""""""""""""""""""""""""""""""""""%a3% 1"3"c"1% /DD;9:D;F%N9Y;FD9?;F%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%a1% 1"3"c"1"3% *:FGXX9F7:R;%J7:R8<7D9LG;%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%a1% 1"3"c"1"1% /DD;9:D;%V<J7DITK9=9798;%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%a1% 1"3"c"1"a% (7:9X;FD7D9I:F%Y7FD8IT9:D;FD9:7=;F%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%aa% 1"3"c"a% /GD8;F%M7:9X;FD7D9I:F%R=9:9LG;F%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%aa% 1"3"c"a"3% 5=7:N;F%FGNI89J78;F%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%aa% 1"3"c"a"1% /DD;9:D;%N;%=Z7JJ78;9=%Y<:9D7=%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%ac% 1"3"c"a"a% /DD;9:D;F%R78N97LG;F%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%ac% 1"3"c"a"c% /DD;9:D;F%IFD<I78D9RG=798;F%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%ac% 1"3"c"a"`% /DD;9:D;F%0$6%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%ac% 1"3"`% -89F;%;:%RV78Y;%DV<87J;GD9LG;%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%ac% % 3c% % 1"3"`"3% -89F;%;:%RV78Y;%N;F%M7:9X;FD7D9I:F%JG=MI:798;F%"""""""""""""""""""""""""""""""""""""""""""""""%a`% 1"3"`"1% -89F;%;:%RV78Y;%N;F%M7:9X;FD7D9I:F%N9Y;FD9?;F%"""""""""""""""""""""""""""""""""""""""""""""""""""%ab% 1"3"`"a% /GD8;F%D879D;M;:DF%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%a>% 1"3"`"c% +IG?;==;F%DV<87J;GD9LG;F%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%a>% 1"3"b% '?I=GD9I:%;D%J8I:IFD9R%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%aA% 8=8% ,?HBIJ>KAG%FGE%HBH@L>JDBKE%MBKNDO@GE%GJ%P>AJQIDGKKGE%F>KE%L>%?@ABCDEADFBEG%========%R9% 1"1"3% &;FR89JD9I:%;D%8h=;%J7DVIY\:;%N;%=7%RI=I:9F7D9I:%XI:Y9LG;%RV;g%=;%J7D9;:D%7DD;9:D%N;% MGRI?9FR9NIF;%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%c2% 1"1"3"3% 6;F%RV7MJ9Y:I:F%X9=7M;:D;G^%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%c3% 1"1"3"3"3% !"#$%&'(()"%FJ"%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%c3% 1"1"3"3"1% *+$,-"#-%').%FJ"%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%c>% 1"1"3"3"a% /GD8;F%RV7MJ9Y:I:F%X9=7M;:D;G^%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%c@% 1"1"3"1% 6;F%=;?G8;F%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%`3% 1"1"3"1"3% /01,',0%FJ"%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%`3% 1"1"3"1"1% /GD8;F%=;?G8;F%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%`1% 1"1"1% &;FR89JD9I:%;D%8h=;%J7DVIY\:;%N;F%K7RD<89;F%RV;g%=;%J7D9;:D%7DD;9:D%N;% MGRI?9FR9NIF;%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%`1% 1"1"1"3% 2"$),-.-10"%0$%)&'1-"0%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%`c% 1"1"1"1% *30#45(-+-++)"%0)%$)"%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%`b% 1"1"1"a% *3$1-3%-#4-.-10"%.0(3-#4'('0%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%`>% 1"1"1"c% 6;%RIMJ=;^;%6)%74-(,$%'08+$#0+'0%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%`A% 1"1"1"`% 6;F%MERIK7RD<89;F%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%b2% S% 1'2!#T!#%#!%'<U#1!,3$%==============================================================================================%V8% R% &0!,#2!$%#!%.#!"'+#$%=============================================================================================%VS% R=;% +GEAIDHJDBK%FGE%HBH@L>JDBKE%QJ@FDQGE%======================================================================%VR% c"3"3% 'FJ\R;F%XI:Y9LG;F%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%bc% c"3"1% 'FJ\R;F%K7RD<89;::;F%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%b@% R=8% +GEAIDHJDBK%FGE%>@JIGE%H>I>?WJIGE%===========================================================================%X9% % % 3`% c"1"3% &97K\D;%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%>2% c"1"1% 'D7D%J7:R8<7D9LG;%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%>2% c"1"a% *:N9R;%N;%(7FF;%)I8JI8;==;%P%*()%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%>3% c"1"c% H;^;%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%>1% c"1"`% (GD7D9I:F%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%>1% c"1"b% /Y;%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%>1% c"1">% +IMK8;%N;%RG8;F%NZ7:D9K9ID9LG;F%9:D87?;9:;GF;F%J78%7:%"""""""""""""""""""""""""""""""""""""""""%>a% c"1"A% -89F;%7G%=I:Y%RIG8D%NZ7g9DV8IMER9:;%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%>c% c"1"@% ,879D;M;:DF%7:D9K9ID9LG;F%9:V7=<F%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%>`% c"1"32% ,879D;M;:DF%7:D9XI:Y9LG;F%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%>b% c"1"33% C'(H%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%>>% :% )#$(*!0!$%==================================================================================================================%XY% :=;% +BKKQGE%ALDKDO@GE%GJ%ABLBKDE>JDBK%MBKNDO@G%=============================================================%XY% `"3"3% &97K\D;%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%>@% `"3"1% 'D7D%J7:R8<7D9LG;%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%>@% `"3"a% *:N9R;%N;%(7FF;%)I8JI8;==;%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%A2% `"3"c% H;^;%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%A2% `"3"`% (GD7D9I:F%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%A2% `"3"b% /Y;%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%A2% `"3">% ,879D;M;:DF%7:D9XI:Y9LG;F%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%A3% `"3"A% ,879D;M;:DF%7:D9K9ID9LG;F%9:V7=<F%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%A3% `"3"@% /g9DV8IMER9:;%7G%=I:Y%RIG8D%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%A1% `"3"32% )G8;F%NZ7:D9K9ID9LG;F%9:D87?;9:;GF;F%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%A1% `"3"33% C'(H%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%A1% :=8% )GAZGIAZG%F/>EEBAD>JDBKE%GKJIG%LGE%GEHWAGE%MBKNDO@GE%GJ%P>AJQIDGKKGE%====================%[8% `"1"3% !"#$%&'(()"%9).'&03)"%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%A1% `"1"1% *+$,-"#-%').%0#'-"#$%.).%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%Aa% `"1"a% /(0,-"#-%').%FJ"%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%Aa% `"1"c% :$-".'34'0%0%&'((0+$0%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%Aa% % % 3b% V% +,$1($$,'2%================================================================================================================%[R% V=;% #HDFQ?DBLBNDG%MBKNDO@G%===========================================================================================%[R% V=8% 0EEBAD>JDBKE%FGE%GEHWAGE%MBKNDO@GE%>CGA%LGE%H>I>?WJIGE%ALDKDO@GE%===========================%[X% V=S% 0EEBAD>JDBKE%GKJIG%LGE%GEHWAGE%MBKNDO@GE%GJ%P>AJQIDGKKGE%========================================%Y9% b"a"3% !"#$%&'(()"%9).'&03)"%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%@2% b"a"3"3% !"#$%&'(()"89).'&03)"%;D%*+$,-"#-%').80#'-"#$%.).%""""""""""""""""""""""""""""""""""""""%@2% b"a"3"1% !"#$%&'(()"89).'&03)"%;D%2"$),-.-10"80$%)&'1-"0%"""""""""""""""""""""""""""""""""""""""""""%@3% b"a"3"a% !"#$%&'(()"%9).'&03)"%;D%*3$1-3%-#4-.-10"%.0(3-#4'('0%""""""""""""""""""""""""""""""""""%@3% b"a"3"c% !"#$%&'(()"89).'&03)"%;D%MERIK7RD<89;F%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%@1% b"a"1% *+$,-"#-%').%0#'-"#$%.).%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%@1% b"a"1"3% *+$,-"#-%').%0#'-"#$%.).%;D%2"$),-.-10"%0$%)&'1-"0%""""""""""""""""""""""""""""""""%@1% b"a"1"1% *+$,-"#-%').%;D%*30#45(-+-++)"80)%$)"8M<D9T$%""""""""""""""""""""""""""""""""""""""""""""""""%@a% b"a"a% :$-".'34'0%0%&'((0+$0%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%@a% V=R% ,KJQI\JE]%LD?DJGE%FG%L/QJ@FG%GJ%HGIEHGAJDCGE%FG%IGAZGIAZG%==========================================%YR% X% 1'21*($,'2%===============================================================================================================%YV% [% <,<*,'4)0&",#%===========================================================================================================%Y[% Y% 022#T#$%===================================================================================================================%;9S% % % % 3>% *,$!#%+#$%3,4()#$% % #9YG8;% 3%P% '?I=GD9I:% NG% :IMK8;% N;% J7D9;:DF% 7DD;9:DF% N;% MGRI?9FR9NIF;% ;D% NG% JIG8R;:D7Y;% NZ7NG=D;F%e3A%7:F%;D%J=GFf%N;JG9F%3@@1%e$#(S%122@f%"""""""""""""""""""""""""""""""""""""""""""""""""""""""%11! #9YG8;%1%P%HD8GRDG8;%N;%=7%J8ID<9:;%)#,$%e9FFG;%N;%)V9:;D%$38/-((S%122af%"""""""""""""""""""""""""""""""""%1a! #9YG8;%a%P%#I:RD9I::;M;:D%NG%R7:7=%RV=I8G8;%)#,$%e9FFG;%N;%)V9:;D%$38/-((S%122af%"""""""""""""""%1a! #9YG8;%cP%$<YG=7D9I:%N;F%X=G^%9I:9LG;F%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%1c! #9YG8;%`%P%)=7FF9X9R7D9I:%N;F%MGD7D9I:F%NG%Y\:;%)#,$S%NZ7J8\F%i;=FV%j%HM9DVS%3@@a%""""""""""""%1b! #9YG8;%bP%(7:9X;FD7D9I:F%R=9:9LG;F%=9<;F%B%=Z7RD9?9D<%N;%)#,$%"""""""""""""""""""""""""""""""""""""""""""""""""""%1>! #9YG8;%>%P%/=YI89DVM;%NG%N<J9FD7Y;%:<I:7D7=%N;%=7%MGRI?9FR9NIF;%e9FFG;%N;%$IGFF;E%$38/-((S% 1232f%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%1@! #9YG8;%A%P%'?I=GD9I:%N;%=ZkY;%M<N97:%N;%FG8?9;%N;F%J7D9;:DF%MGRI?9FR9NIF9LG;F%7G^%'D7DFT!:9F% ;:D8;%3@Ab%;D%1232%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%aA! #9YG8;%@P%'?I=GD9I:%NG%:IMK8;%N;%J7D9;:DF%D87:FJ=7:D<F%N;JG9F%3@@1%"""""""""""""""""""""""""""""""""""%a@! #9YG8;% 32%P% )V7MJ9Y:I:F% X9=7M;:D;G^% 7FFIR9<F% B% =7% MGRI?9FR9NIF;% R=7FF<F% F;=I:% =;G8% X8<LG;:R;% ;D% =;G8% R7J7R9D<% B% RI=I:9F;8% RV8I:9LG;M;:D% =;F% ?I9;F% 8;FJ987DI98;F% e-9V;D% $38 /-((S%122@f%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%c3! #9YG8;%33%P &9XX<8;:D;F%XI8M;F%R=9:9LG;F%N;F%7FJ;8Y9==IF;F%K8I:RVIJG=MI:798;F%e5;8M7GN%$38 /-((S%122`f"%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%ca! #9YG8;%31%P%)=7FF9X9R7D9I:%N;F%FD7N;F%NZ/l-/%e6;%lIG8Y;I9F%$38/-((S%1233f"%"""""""""""""""""""""""""""""%cc! #9YG8;%3a%P%l7RD<89;F%R=9:9LG;M;:D%9MJI8D7:D;F%N7:F%=7%MGRI?9FR9NIF;%F;=I:%=ZkY;%;:%122@% `a! #9YG8;%3c%P%-IJG=7D9I:%N;%K7RD<89;F%9FI=<;F%;:%122@%RIMJ78<;%B%R;==;F%9FI=<;F%;:%3@@@%"""""""%`c! #9YG8;%3`%P%)IMJIF9D9I:%NG%RIMJ=;^;%6;8+$#0+'0%e69JGM7S%1232f%""""""""""""""""""""""""""""""""""""""""""%`@! #9YG8;%3b%P%&9FD89KGD9I:%N;F%;FJ\R;F%N;%6)%74-(,$%'0%7G^%'D7DFT!:9F%e69JGM7S%1232f%""""""""""""%b2! #9YG8;% 3>% P% &;FR89JD9I:% N;% =7% RI=I:9F7D9I:% XI:Y9LG;% RV;g% =;F% J7D9;:DF% 7DD;9:DF% N;% MGRI?9FR9NIF;%7G%).!%N;%$IG;:%""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%b`! #9YG8;%3A%P%+IMK8;%N;%J7D9;:DF%7G%).!%N;%$IG;:%RI=I:9F<F%J78%N;F%;FJ\R;F%7FJ;8Y9==798;F%"%bb! #9YG8;%3@%P%)=7FF9X9R7D9I:%N;F%;FJ\R;F%XI:Y9LG;F%F;=I:%=;G8%X8<LG;:R;%N;%RI=I:9F7D9I:%"""""""""%bA! #9YG8;%12%P%6;F%N9XX<8;:DF%DEJ;F%N;%RI=I:9F7D9I:%XI:Y9LG;%RV;g%=;F%J7D9;:DF%NG%).!%N;%$IG;: %"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%b@! % % 3A% #9YG8;%13%P%&;FR89JD9I:%N;%=7%RI=I:9F7D9I:%K7RD<89;::;%RV;g%=;F%J7D9;:DF%NG%).!%N;%$IG;:%""%>2! #9YG8;%11%P%&;FR89JD9I:%N;%=7%JIJG=7D9I:%<DGN9<;%F;=I:%=Z*()%"""""""""""""""""""""""""""""""""""""""""""""""""%>3! #9YG8;%1a%P%$<J78D9D9I:%N;%=7%JIJG=7D9I:%<DGN9<;%F;=I:%=ZkY;%""""""""""""""""""""""""""""""""""""""""""""""""""%>a! #9YG8;% 1c%P% $;J8<F;:D7D9I:% N;% =Z;XX;RD9X% 7E7:D% 8;_G% N;F% RG8;F% NZ7:D9K9ID9LG;F% J78% ?I9;% 9:D87?;9:;GF;%"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""%>c! #9YG8;%1`%P%$;J8<F;:D7D9I:%N;%=Z;XX;RD9X%7E7:D%8;_G%N;F%RG8;F%NZ7g9DV8IMER9:;%""""""""""""""""""""""%>`! #9YG8;%1b%P%$;J8<F;:D7D9I:%N;%=Z;XX;RD9X%7E7:D%8;_G%N;F%RG8;F%NZ7:D9K9ID9LG;F%9:V7=<F%"""""""""""%>b! #9YG8;%1>%P%$;J8<F;:D7D9I:%N;%=Z;XX;RD9X%7E7:D%8;_G%N;F%D879D;M;:DF%7:D9XI:Y9LG;F%"""""""""""""""%>>! #9YG8;%1A%P%$<J78D9D9I:%N;%=7%JIJG=7D9I:%;:%XI:RD9I:%NG%C'(H%""""""""""""""""""""""""""""""""""""""""""""""%>A% % % % % % % % % % % % % % % % % % % 3@% ; ,2!)'+(1!,'2% 67% MGRI?9FR9NIF;S% <Y7=;M;:D% 7JJ;=<;% X9K8IF;% mEFD9LG;% NG% J7:R8<7FS% ;FD% G:;% M7=7N9;% Y<:<D9LG;%LG9%RIMJD;%J8\F%N;%b222%J7D9;:DF%;:%#87:R;"%'==;%8;FD;%G:;%M7=7N9;%Y87?;%M]M;% F9% =Z;FJ<87:R;% N;% ?9;% 7% RI:F9N<87K=;M;:D% 7GYM;:D<% Y8kR;% 7G^% J8IY8\F% DV<87J;GD9LG;F"% '==;% M;D%;:%O;G%J8IY8;FF9?;M;:D%=;%J8I:IFD9R%?9D7=%;:%879FI:%N;%F;F%RIMJ=9R7D9I:F%8;FJ987DI98;F"% ':%;XX;DS%=7%XI8M7D9I:%N;%MGRGF%?9FLG;G^%;:D87n:;%=ZIKFD8GRD9I:%N;F%?I9;F%8;FJ987DI98;F%79:F9% LGZG:;%8<7RD9I:%9:X=7MM7DI98;%LG9%X7?I89F;:D%=7%RI:D7M9:7D9I:%J78%N;F%;FJ\R;F%K7RD<89;::;F% ;D% XI:Y9LG;F"% 6;F% RI:F<LG;:R;F% ?I:D% ;:% ]D8;% G:;% 7RR<=<87D9I:% NG% N<R=9:% N;% =7% XI:RD9I:% 8;FJ987DI98;"% )Z;FD% Y<:<87=;M;:D% 7G% K7R9==;% JEIRE7:9LG;% LG;% =ZI:% 7DD89KG;% G:% 8h=;% R;:D87=% N7:F% R;DD;% <?I=GD9I:"% -78M9% =;F% 7GD8;F% ;FJ\R;F% M9R8IK9;::;FS% =;F% RV7MJ9Y:I:F% M9R8IFRIJ9LG;F% FI:D% R=7FF9LG;M;:D% 8;J8<F;:D<F% J78% !"#$%&'(()"8 9).'&03)"% NI:D% =;% JIG?I98% J7DVIY\:;% FZ;^J89M;% ;FF;:D9;==;M;:D% FIGF% XI8M;% NZG:;% 7FJ;8Y9==IF;% K8I:RVIJG=MI:798;% 7==;8Y9LG;%e/l-/f"%);J;:N7:DS%=Z7==I:Y;M;:D%N;%=7%FG8?9;%;D%=Z9:D;:F9X9R7D9I:%N;%=7%FG8?;9==7:R;% ;D% N;F% D879D;M;:DF% I:D% 7M;:<F% B% N9FRGD;8% NZ7GD8;F% RI:F<LG;:R;F% N;% =7% J8<F;:R;% NZ!"#$%&'(()"8 9).'&03)"% ;D% N;% =7% J8<F;:R;% NZ7GD8;F% ;FJ\R;F% RIMM;% /01,',08 0(<'+01"S% *+$,-"#-%').8 0#'-"#$%.).% IG% !"#$%&'(()"8 3$%%$)""% -78M9% R;==;FTR9S% R;8D79:;F% FI:D% RI:F9N<8<;F%RIMM;%N;F%J7DVIY\:;F%<M;8Y;:DF%7=I8F%LG;%=;%8h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dc`22% :79FF7:R;F% e67:Y;78N% $38 /-((S% 1232f"% 0:% ;FD9M;% B% ;:?98I:% G:;% J;8FI::;% FG8% a2% =;% :IMK8;%N;%JI8D;G8%NZG:%7==\=;%MGD<%e)V9:;D%$38/-((S%122af"%% % ':% 122@S% `b`2% J7D9;:DF% 7DD;9:DF% I:D% <D<% ;:8;Y9FD8<F% 7G% $;Y9FD8;% #87:_79F% N;% =7% (GRI?9FR9NIF;%e$#(f"%0:%;FD9M;%R;%RV9XX8;%<LG9?7=;:D%B%@2o%N;%=7%DID7=9D<%N;%=7%JIJG=7D9I:% 7DD;9:D;%;:%#87:R;"%% % &;%J=GFS%I:%RI:FD7D;%LG;%=Z;XX;RD9X%N;%J7D9;:DF%;:8;Y9FD8<%RV7LG;%7::<;%7G%$;Y9FD8;%;FD% ;:%7GYM;:D7D9I:%N;JG9F%3@@13%RIMM;%=;%MI:D8;%=;%Y87JV9LG;%FG9?7:D%P%% %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 3 %l9=7:%N;F%NI::<;F%122@S%$;Y9FD8;%#87:_79F%N;%=7%(GRI?9FR9NIF;%% VDDJPddppp"?79:R8;=7MGRI"I8Yd;qGJ=I7NdJNXd87JJI8Dq8;Y9FD8;q122@"JNX% % % % % 13% Pourcentage d'adultes 100 Nombre de patients 6 000 5 500 90 Nombre de patients Pourcentage d'adultes 5 000 80 4 500 70 4 000 60 3 500 50 3 000 40 2 500 30 2 000 20 1 500 10 1 000 19 92 993 994 995 996 997 998 999 000 001 002 003 004 005 006 007 008 009 1 1 1 1 1 2 1 2 2 2 2 2 2 2 2 1 2 Années 0 % % 3DN@IG% ;%^% #CBL@JDBK% F@% KB?PIG% FG% H>JDGKJE%>JJGDKJE% FG% ?@ABCDEADFBEG% GJ% F@% HB@IAGKJ>NG% F/>F@LJGE%_;[%>KE%GJ%HL@E`%FGH@DE%;YY8%_)3.]%899Y`% % % );DD;%J7DVI=IY9;%;FD%NG;%B%G:;%MGD7D9I:%NG%Y\:;%F9DG<%FG8%=;%K87F%=I:Y%NG%RV8IMIFIM;% >% e>La3f% RIN7:D% JIG8% G:;% J8ID<9:;% :IMM<;% )#,$% e/5"3'+8 9'<%-"'"8 3%01".$.<%01$8 +-1,)+301+$8%$&)(03-%f"% 8=;=8 &ZaEDBH>JZBLBNDG% 8=;=8=; *>%HIBJQDKG%13!)%% 67% J8ID<9:;% )#,$% ;FD% F9DG<;% 7G% :9?;7G% NG% Jh=;% 7J9R7=% N;F% R;==G=;F% <J9DV<=97=;F"% '==;% ;FD% RIMJIF<;% N;% N;G^% NIM79:;F% D87:FM;MK87:798;F% e,(3% ;D% ,(1f% RV7RG:% RIMJI8D7:D% F9^% 8<Y9I:F%D87:FM;MK87:798;FS%N;%N;G^%F9D;F%N;%X9^7D9I:%N;F%:GR=<ID9N;F%eH#+3%;D%H#+1f%;D%NZG:% NIM79:;%8<YG=7D;G8%e$f"%% 67%J8ID<9:;%)#,$%;^;8R;%N;%:IMK8;GF;F%XI:RD9I:F%NI:D%R;=G9%N;%R7:7=%RV=I8;%7RD9?<%J78% =Z7N<:IF9:;% MI:IJVIFJV7D;% RER=9LG;% e/(-Rf"% '==;% 7Y9D% <Y7=;M;:D% RIMM;% 8<YG=7D;G8% NZ7GD8;F%R7:7G^%9I:9LG;FS%:ID7MM;:D%RV=I8;S%FIN9GM%;D%JID7FF9GM%e)V9:;D%$38/-((S%122af"% % % 11% % 3DN@IG%8%^%$JI@AJ@IG%FG%L>%HIBJQDKG%13!)%_DEE@G%FG%1ZDKGJ%!"#$%&&]%899S`% % 6Z/-(R%J;8M;D%=7%JVIFJVI8E=7D9I:%NG%NIM79:;%8<YG=7D;G8%$%J78%=7%J8ID<9:;%m9:7F;%-r/"% );DD;% 9:D;87RD9I:% ;:Y;:N8;% =7% X9^7D9I:% N;% =Z/,-% FG8% H#+3"% 6ZVEN8I=EF;% N;% =Z/,-% e/N<:IF9:;% ,89JVIFJV7D;f% ;:% /&-% e/N<:IF9:;% &9JVIFJV7D;f% RI:NG9D% B% =ZIG?;8DG8;% NG% R7:7=% RV=I8;"% -78% Y87N9;:D% <=<RD8IRV9M9LG;S% =;F% 9I:F% RV=I8G8;F% FI8D;:D% B% =Z;^D<89;G8% N;% =7% R;==G=;"% -G9F% =ZIJ<87D9I:%9:?;8F;%F;%J8ING9D%P%9=%E%7%N<JVIFJVI8E=7D9I:%;D%9:D;87RD9I:%;:D8;%=Z/,-%;D%H#+1%R;% LG9%F;%D87NG9D%J78%G:;%X;8M;DG8;%NG%R7:7=%e)V9:;D%$38/-((S%122af"% % % % % 3DN@IG%S%^%3BKAJDBKKG?GKJ%F@%A>K>L%AZLBI@IG%13!)%_DEE@G%FG%1ZDKGJ%!"#$%&&]%899S`% % 67% J8ID<9:;% )#,$% 9:D;8?9;:D% NI:R% N7:F% =7% 8<YG=7D9I:% N;F% D87:FJI8DF% 9I:9LG;F% LG9% Y<:\8;:D%N;F%Y87N9;:DF%IFMID9LG;F"%':%;XX;DS%RV7LG;%R;==G=;%N;%=Z<J9DV<=9GM%K8I:RV9LG;%;FD% % % 1a% RIMJIF<;% N;% R7:7G^% F<R8<D7:D% NG% RV=I8;% e)#,$% ;D% 0$))% IG% =)3>0%,(58 ?$+3'95'1&8 /4(-%',$8 /4011$(f% ;D% N;% R7:7G^% FIN9LG;F% '+7)% e@#'34$('0(8 *-,').8 /4011$(f% 7KFI8K7:D% =;% FIN9GM"% 67% J8ID<9:;%)#,$%9:V9K;%=;F%R7:7G^%':7)%=9M9D7:D%=Z;:D8<;%N;%FIN9GM%N7:F%=7%R;==G=;%;D%7RD9?;%=;F% R7:7G^%0$))%J;8M;DD7:D%=7%FI8D9;%N;%RV=I8;%VI8F%N;%=7%R;==G=;"%% % );F% N;G^% MIG?;M;:DF% ?I:D% MING=;8% =;F% D87:FX;8DF% N;% =9LG9N;% ;:D8;% =7% 8<Y9I:% FIGFT <J9DV<=97=;% ;D% =7% FG8X7R;% N;F% ?I9;F% 7<89;::;F"% *=F% J78D9R9J;:D% NI:R% B% =7% 8<YG=7D9I:% N;% =ZVEN87D7D9I:%NG%=9LG9N;%N;%FG8X7R;%K8I:RV9LG;%LG9%8;RIG?8;%=Z<J9DV<=9GM%N;%FG8X7R;%N;F%?I9;F% 7<89;::;F%e)V9:;D%$38/-((S%122af"%);DD;%8<YG=7D9I:%;FD%XI:N7M;:D7=;%JIG8%7FFG8;8%=7%R=7987:R;% NG%MGRGF%K8I:RV9LG;%Y8kR;%B%=Z7RD9I:%N;F%R9=F"%% % % % % % 3DN@IG%R^%)QN@L>JDBK%FGE%ML@b%DBKDO@GE1% %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 1 %67%MGRI?9FR9NIF;%;D%=;%Y\:;%)#,$% VDDJPddRV8I:IF"7RD9?;p;K"X8dUG9Rm-=7R;d7RR;FM7Nd-7Y;69K878EA`1`b'/322ab2aA@":FXdVq*: N;^dA`c/a'b)3#@)a3>)A`1`>3c>22`bb23bd% % 1c% % 8=;=8=8 1BKEQO@GKAGE%FG%L>%?@J>JDBK%c%L/BIDNDKG%FG%L>%?@ABCDEADFBEG% )V;g%G:%J7D9;:D%7DD;9:D%N;%MGRI?9FR9NIF;S%=7%XI:RD9I:%N;%=7%J8ID<9:;%)#,$%;FD%7=D<8<;%;D% =7%8<YG=7D9I:%N;F%X=G^%9I:9LG;F%;FD%M7G?79F;"%0:%IKF;8?;%G:;%F<R8<D9I:%9:FGXX9F7:D;%N;%RV=I8;% ;D% G:;% VEJ;87KFI8JD9I:% N;% FIN9GM% N7:F% =;F% R;==G=;FS% LG9% ;:D87n:;% G:;% N<FVEN87D7D9I:% NG% =9LG9N;%N;%FG8X7R;%K8I:RV9LG;%;D%G:%D8IGK=;%N;%=Z7RD9I:%N;F%R9=F%N;%=Z<J9DV<=9GM%K8I:RV9LG;"% 6Z7RRGMG=7D9I:% NG% MGRGF% X7?I89F;% =;F% 9:X;RD9I:F% K8I:RVIJ=GMI:798;F% ;D% =7% 8<7RD9I:% 9:X=7MM7DI98;%=IR7=;%RV;g%=;F%J7D9;:DF%7DD;9:DF%N;%MGRI?9FR9NIF;%e)V9:;D%$38/-((S%122af"% 8=;=8=S 1BIIQL>JDBK% GKJIG% L>% ?@J>JDBK% F@% NWKG% GJ% L>% MBKAJDBK% FG% L>% HIBJQDKG%13!)% 6;% J7D9;:D% 7DD;9:D% N;% MGRI?9FR9NIF;% J;GD% ]D8;% VIMIgEYID;% RZ;FD% B% N98;% JI8D;G8% N;% =7% M]M;%MGD7D9I:%FG8%=;F%N;G^%7==\=;F%NG%Y\:;%)#,$S%IG%K9;:%V<D<8IgEYID;"%&7:F%R;%R7FS%9=%F;87% JI8D;G8%N;%N;G^%MGD7D9I:F%N9XX<8;:D;F"% % /GOIG8NZVG9S% =;F% RV;8RV;G8F% I:D% JG% M;DD8;% ;:% <?9N;:R;% J=GF% N;% 3b22% MGD7D9I:F% N9XX<8;:D;F%NG%Y\:;%N;%=7%MGRI?9FR9NIF;"%67%J=GF%X8<LG;:D;S%J8<F;:D;%RV;g%A2o%N;F%J7D9;:DFS% ;FD%=7%MGD7D9I:%&#`2A%LG9%F;%D87NG9D%J78%=7%N<=<D9I:%N;%=7%JV<:E=7=7:9:;%;:%JIF9D9I:%`2Aa"%% % 6;F% RI:F<LG;:R;F% N;% R;F% MGD7D9I:F% FG8% =7% XI:RD9I:% N;% =7% J8ID<9:;% )#,$% J;G?;:D% ]D8;% R=7FF<;F%;:%F9^%R7D<YI89;F%N9XX<8;:D;F%e)V9:;D%$38/-((S%122a%s%)8GEJ;::9:RmS%1232f%P% % • $&'((!# )8P% /KF;:R;% N;% J8INGRD9I:% N;% =7% J8ID<9:;% IG% FE:DV\F;% NZG:;% J8ID<9:;% 7K;887:D;S%D8I:LG<;"%%)Z;FD%=;%R7F%N;%>o%N;F%J7D9;:DF%7DD;9:DF%N;%MGRI?9FR9NIF;"% • $&'((!# ))#^%&;FD8GRD9I:%N;%=7%J8ID<9:;%M7=XI8M<;%7G%RIG8F%N;%F7%M7DG87D9I:%N7:F%=;% FEFD\M;%8<D9RG=I%;:NIJ=7FM9LG;T7JJ78;9=%N;%5I=Y9"%)Z;FD%=;%R7F%N;%=7%MGD7D9I:%&#`2A% LG9%DIGRV;%A2o%N;F%J7D9;:DF"% %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% a %$;Y9FD8;%#87:_79F%N;%=7%(GRI?9FR9NIF;"%l9=7:%N;F%NI::<;F%122@"%% VDDJPddppp"?79:R8;=7MGRI"I8Yd;qGJ=I7NdJNXd87JJI8Dq8;Y9FD8;q122@"JNX% % % 1`% • $&'((!# )))%P%/XX;RD7D9I:%N;%=7%8<YG=7D9I:%NG%R7:7=%RV=I8;d)#,$%:ID7MM;:D%7G%:9?;7G% N;F%9:D;87RD9I:F%;:D8;%=Z/,-%;D%=;F%F9D;F%N;%X9^7D9I:%N;F%:GR=<ID9N;F%P%ao%N;F%M7=7N;F% ;:%FI:D%?9RD9M;F"%% $&'((!# )*%P% &9M9:GD9I:% N;% =7% J;8M<7K9=9D<% 7G% RV=I8;% NG% R7:7=% )V=I8;d)#,$S% LG9% F;% • D87NG9D%J78%G:;%7:IM7=9;%N;%RI:NGRD9I:%D87:FM;MK87:798;%NG%RV=I8;"%% $&'((!# *#+% *:N9?9NG7=9F<;% J=GF% 8<R;MM;:DS% =;F% MGD7D9I:F% N;% R;DD;% R=7FF;% ;:D879:;:D% • G:;%N9M9:GD9I:%N;%=7%LG7:D9D<%N;%=Z;^J8;FF9I:%M;MK87:798;%N;%=7%J8ID<9:;%IG%N;%F7% FD7K9=9D<"%% % # % % 3DN@IG%:%^%1L>EEDMDA>JDBK%FGE%?@J>JDBKE%F@%NWKG%13!)]%F/>HIWE%dGLEZ%e%$?DJZ]%;YYSc% 8=;=8=R )GL>JDBKE%NQKBJaHGfHZQKBJaHG%% % *=%;^9FD;%N;F%XI8M;F%J=GF%IG%MI9:F%F<?\8;F%N;%=7%M7=7N9;%;:%XI:RD9I:%N;%=7%:7DG8;%N;F% MGD7D9I:F% NG% Y\:;% )#,$"% ':% ;XX;DS% =;F% MGD7D9I:F% N;% R=7FF;% *S% **% ;D% ***% 7G879;:D% N;F% RI:F<LG;:R;F%JV<:IDEJ9LG;F%J=GF%F<?\8;F%LG;%R;==;F%N;F%R=7FF;F%*C%;D%C"%% % % % % %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% c %67%MGRI?9FR9NIF;%;D%=;%Y\:;%)#,$% VDDJPddRV8I:IF"7RD9?;p;K"X8dUG9Rm-=7R;d7RR;FM7Nd-7Y;69K878EA`1`b'/322ab2aA@":FXdVq*: N;^dA`c/a'b)3#@)a3>)A`1`>3c>22`bb23bd% % 1b% % % &;%J=GFS%=7%Y87?9D<%N;%=Z;^J8;FF9I:%N;%=7%M7=7N9;%N<J;:N%NG%XI:RD9I::;MM;:D%LG7=9D7D9X% ;D%LG7:D9D7D9X%N;%=7%J8ID<9:;%)#,$%P%J=GF%FI:%:9?;7G%NZ7RD9?9D<%;FD%K7FS%J=GF%=;%JV<:IDEJ;%;FD% F<?\8;%e)V9:;D%$38/-((S%122af"% % );R9%;FD%9==GFD8<%J78%=;%Y87JV9LG;%FG9?7:D%P%% % ,%-."/%-#0!#&'#12%"3/-!#$,45# % 61%72.!-"'8!#0!#&'#9'&!72#-%2:'&!;# $%-(3<7!-.!(#.&/-/<7!(# % % Pas de symptômes 50% (hétérozygote) Risque de pancréatite, sinusite, atteinte pulmonaire, aspergillose broncho-pulmonaire allergique 10% Absence bilatérale de canaux déférents 5% ! Cl- sudoral, atteinte pulmonaire 1% Atteinte pancréatique (précoce) mucoviscidose % % 3DN@IG%V^%.>KDMGEJ>JDBKE%ALDKDO@GE%LDQGE%c%L/>AJDCDJQ%FG%13!)`% % !:;%8;=7D9I:%Y<:IDEJ;dJV<:IDEJ;%7%<D<%M9F;%;:%<?9N;:R;%FG8%=7%XI:RD9I:%J7:R8<7D9LG;"% -78%RI:F<LG;:DS%=;F%XI8M;F%7?;R%9:FGXX9F7:R;%J7:R8<7D9LG;%FI:D%=;%J=GF%FIG?;:D%7FFIR9<;F%B% N;F%MGD7D9I:F%N;%R=7FF;%*S%**%;D%***"%6;%JV<:IDEJ;%;FD%OGY<%F<?\8;%%e./HS%122@f"% %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% `% ./HS% 122@%P% 6;% N<J9FD7Y;% :<I:7D7=% FEFD<M7D9LG;% N;% =7% MGRI?9FR9NIF;% ;:% X87:R;% P% <D7D% N;F% =9;G^%;D%J;8FJ;RD9?;F%7J8\F%`%7:F%N;%XI:RD9I::;M;:D% VDDJPddppp"V7FTF7:D;"X8dJI8D79=dGJ=I7NdNIRFd7JJ=9R7D9I:dJNXd122@T 2cd87JJI8DqN;J9FD7Y;q:;I:7D7=qFEFD;M7D9LG;qN;q=7qMGRI?9FR9NIF;q;:qX87:R;"JNX% % % % 1>% 67%8;=7D9I:%;:D8;%=;%Y<:IDEJ;%;D%=;%JV<:IDEJ;%7G%:9?;7G%N;%=7%XI:RD9I:%JG=MI:798;%;FD% MI9:F% =9:<798;"% );=7% =79FF;% J;:F;8% LG;% =Z;^J8;FF9I:% R=9:9LG;% N;% =7% M7=7N9;% F;879D% 9:X=G;:R<;% J78%NZ7GD8;F%X7RD;G8F%F7:F%LG;%=;F%M<R7:9FM;F%;:%FI9;:D%K9;:%RI::GF%P%Y\:;F%MIN9X9R7D;G8FS% D879D;M;:DFS%;:?98I::;M;:D%e)V9:;D%$38/-((S%122af"%% 8=;=S +D>NKBEJDA%% 6;%N<J9FD7Y;%:<I:7D7=%N;%=7%MGRI?9FR9NIF;%e&+(f%7%<D<%Y<:<87=9F<%;:%#87:R;%B%J78D98%N;% 1221%;D%RI:R;8:;%LG7F9M;:D%=7%DID7=9D<%N;%=7%JIJG=7D9I:"%*=%:Z;FD%R;J;:N7:D%J7F%IK=9Y7DI98;"% 0:%;FD9M;%G:;%FI9^7:D79:;%N;%J78;:DF%J78%7:%FG8%A22%222%LG9%8;XGF;:D%=;%&+(%e$IGFF;E%$38 /-((S%1232f"%% 67% OGFD9X9R7D9I:% NG% &+(% F;% D87NG9D% J78% G:;% J89F;% ;:% RV78Y;% 87J9N;% J78% G:;% <LG9J;% FJ<R97=9F<;%I8Y7:9F<;%;:%)$)(%JIG8%N<KGD;8%G:;%FG8?;9==7:R;%;D%G:%D879D;M;:D%J8<RIR;"%% 8=;=S=; *G%+D>NKBEJDA%2QBK>J>L%FG%L>%.@ABCDEADFBEG%B@%+2.% 6;% &+(% ;FD% 8<7=9F<% Y8kR;% 7G% NIF7Y;% N;% =7% D8EJF9:;% 9MMG:I8<7RD9?;% e,*$f"% )Z;FD% G:;% ;:gEM;% F<R8<D<;% J78% =;% J7:R8<7F"% H7% J8<F;:R;% N7:F% =;% F7:Y% 8<FG=D;% NZG:;% IKFD8GRD9I:% N;F% R7:7G^% J7:R8<7D9LG;F% J78% G:% 7M7F% N;% J8ID<9:;% t%9:% GD;8I%u% LG9% ;:Y;:N8;% G:% 8;=78Y7Y;% ;:gEM7D9LG;"%0:%J8IR\N;%B%J78D98%NZG:%<RV7:D9==I:%N;%F7:Y%F<RV<%NG%:IG889FFI:%J8<=;?<%NG% KI8N%;^D;8:;%NG%D7=I:%7G%D8I9F9\M;%OIG8%7J8\F%=7%:79FF7:R;%e./HS%122@f"% H9% =;% D7G^% N;% ,*$% ;FD% FGJ<89;G8% 7G% F;G9=% N;% 2S`% vYd6S% I:% RI:D9:G;% =;% J8IY87MM;% N;% N<J9FD7Y;%7?;R%=;%D;FD%N;%K9I=IY9;%MI=<RG=798;%e$IGFF;E%$38/-((S%1232f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a%!"#$%&&]% 89;9`% 8=;=S=8 *>%IGAZGIAZG%FGE%?@J>JDBKE%F@%NWKG%13!)% 0:%8<7=9F;%R;DD;%8;RV;8RV;%Y8kR;%B%N;F%D;RV:9LG;F%N;%K9I=IY9;%MI=<RG=798;"%*=%:Z;FD%J7F% JIFF9K=;%N;%X798;%G:;%<DGN;%RIMJ=\D;%NG%Y\:;%<D7:D%NI::<%=;%:IMK8;%N;%MGD7D9I:F%N<R89D;F"% );J;:N7:D% ;:% GD9=9F7:D% N;F% m9DF% N;% 12S% a2% ?I98;% `2% MGD7D9I:FS% I:% RIG?8;% J=GF% N;% @2o% N;F% MGD7D9I:F%=;F%J=GF%X8<LG;:D;F%e$IGFF;E%$38/-((S%1232f"%%% H9%I:%N<D;RD;%G:;%IG%N;G^%MGD7D9I:FS%=7%X7M9==;%;FD%;:?IE<;%N98;RD;M;:D%7G%)$)(%7X9:%N;% J8IR<N;8% 7G% D;FD% N;% =7% FG;G8"% ':% 8;?7:RV;S% =Z7KF;:R;% N;% MGD7D9I:% RI:NG9D% B% G:% :IG?;7G% NIF7Y;%N;%=7%,*$%?;8F%=;%13;%OIG8F%7J8\F%=7%:79FF7:R;"%% % % 1@% 8=;=S=S !GEJ%c%L>%E@G@I%_!$`% /J8\F%FD9MG=7D9I:%N;%=7%FGN7D9I:S%=7%FG;G8%;FD%8;RG;9==9;%;D%=7%RI:R;:D87D9I:%N;%RV=I8G8;% ;FD%M;FG8<;"%H9%=;%D7G^%;FD%9:X<89;G8%B%c2%MMI=d6S%R;%D;FD%;FD%RI:F9N<8<%RIMM;%:I8M7="%':% 8;?7:RV;S% F9% =7% ?7=;G8% ;FD% FGJ<89;G8;% IG% <Y7=;% B% b2% MMI=d6S% 9=% ;FD% JIF9D9X"% *=% X7GD% R;J;:N7:D% LG;%N;G^%NIF7Y;F%FI9;:D%8<7=9F<F%JIG8%8;D;:98%=;%N97Y:IFD9R%JIF9D9X%e./HS%122@f"% H9%=;%D7G^%M;FG8<%F;%D8IG?;%;:D8;%c2%;D%b2%MMI=d6S%=;%N97Y:IFD9R%:;%J;GD%J7F%]D8;%<R78D<"%*=% X7GD%N7:F%R;%R7F%8<J<D;8%=;%D;FD%B%=7%FG;G8"%% 8=;=R 1LDKDO@G% 6;% Y\:;% N;% =7% MGRI?9FR9NIF;% ;FD% ;^J89M<% J78% N;% :IMK8;GF;F% R;==G=;F% N;% =ZI8Y7:9FM;S% :ID7MM;:D%7G%:9?;7G%N;F%MGLG;GF;F%K8I:RV9LG;FS%9:D;FD9:7=;FS%N;F%R7:7G^%J7:R8<7D9LG;FS% <J9N9NEM798;FS%M79F%<Y7=;M;:D%7G%:9?;7G%N;F%Y=7:N;F%FGNI89J78;F%;D%N;%=7%?<F9RG=;%K9=9798;S% R;%LG9%;^J=9LG;%=7%Y87:N;%N9?;8F9D<%R=9:9LG;%N;%R;DD;%J7DVI=IY9;"%% 8=;=R=; 0JJGDKJGE%IGEHDI>JBDIGE%% 6Z7DD;9:D;% 8;FJ987DI98;% ;FD% RI:FD9DG<;% N;% D8I9F% RIMJIF7:D;F% <D8I9D;M;:D% =9<;F%P% IKFD8GRD9I:S%9:X=7MM7D9I:%;D%9:X;RD9I:"%'==;%7%G:;%;^J8;FF9I:%R=9:9LG;%J8<RIR;%;D%RI:N9D9I::;% =;%J8I:IFD9R%?9D7=%e&;8;==;%$38/-((S%122af"% )Z;FD%G:%R;8R=;%?9R9;G^%LG9%F;%M;D%;:%J=7R;"%':%;XX;DS%=ZVEJ;8?9FRIF9D<%NG%MGRGF%;:Y;:N8;%G:;% 9:X=7MM7D9I:% 79:F9% LG;% N;F% 9:X;RD9I:F% ?987=;F% ;D% K7RD<89;::;FS% LG9% RI:NG9F;:D% B% G:;% VEJ;8J=7F9;% N;F% R;==G=;F% Y=7:NG=798;F% N;% =Z<J9DV<=9GM% 8;FJ987DI98;S% J8ING9F7:D% G:% ;^R\F% N;% MGRGF"%/%=I:Y%D;8M;S%=Z9:X=7MM7D9I:%RV8I:9LG;%7KIGD9D%B%N;F%MIN9X9R7D9I:F%J8IXI:N;F%N;%=7% FD8GRDG8;%K8I:RV9LG;%e&;:;G?9==;%$38/-((S%122>f"%%% % % % % % a2% 1"3"c"3"3 ='-/>!("'"/%-#.&/-/<7!#.?!@#&!#1!"/"#!->'-"# 67% Y87:N;% X8<LG;:R;% N;F% 9:X;RD9I:F% ?987=;F% RV;g% =;F% J;D9DF% 8;:N% N9XX9R9=;% =Z7DD89KGD9I:% N;% FEMJDhM;F% B% =7% MGRI?9FR9NIF;"% H;G=% =;% R787RD\8;% 8<R9N9?7:D% IG% F<?\8;% N;% K8I:RV9D;F% ;D% N;% K8I:RV9I=9D;F%J;G?;:D%7DD98;8%=Z7DD;:D9I:"%% 6;F% FEMJDhM;F% B% R;D% kY;% FI:D% G:;% DIG^% 8;K;==;S% G:;% 8;FJ987D9I:% F9XX=7:D;% 7FFIR9<;% B% N;F% F9Y:;F%NZVEJ;88<7RD9?9D<%K8I:RV9LG;S%G:%;:RIMK8;M;:D%K8I:RV9LG;"%%);F%M7:9X;FD7D9I:F%F;% 8;D8IG?;:D% RV;g% G:;% Y87:N;% M7OI89D<% N;% :IG889FFI:F% N<J9FD<F% N\F% =ZkY;% N;% 31% MI9F% e&;:;G?9==;%$38/-((S%122>f"%%% 1"3"c"3"1 A9%&7"/%-#0!(#:'-/>!("'"/%-(#2!(1/2'"%/2!(## 6;F%FEMJDhM;F%8;FJ987DI98;F%?I:D%<?I=G;8%J78%JIGFF<;F%7G%RIG8F%N;F%7::<;F%e&;:;G?9==;% $38 /-((S% 122>f"% );F% JIGFF<;F% 7JJ;=<;F% ;^7R;8K7D9I:F% FI:D% =7% RI:F<LG;:R;% N;% RI=I:9F7D9I:F% K7RD<89;::;F% IG% XI:Y9LG;F% X7?I89F<;F% J78% =;% MGRGF% K8I:RV9LG;% ?9FLG;G^% e./HS% 122@f"% 6;F% Y;8M;F% ;D% RV7MJ9Y:I:F% =;F% J=GF% X8<LG;:DF% FI:D% 2"$),-.-10"8 0$%)&'1-"0S% A0$.-#4'()"8 '19()$1B0$S% *30#45(-+-++)"8 0)%$)"S% *3$1-3%-#4-.-10"8 .0(3-#4'('0S8 !"#$%&'(()"8 9).'&03)"w% );F% ;^7R;8K7D9I:F% F;% D87NG9F;:D% J78% G:;% 7GYM;:D7D9I:% N;% =7% DIG^% ;D% NZ;^J;RDI87D9I:F"% 6;F% F<R8<D9I:F%K8I:RV9LG;F%FI:D%<J79FF;F%;D%JG8G=;:D;F"%0:%IKF;8?;%J78XI9F%G:;%N9M9:GD9I:%N;%=7% DI=<87:R;% B% =Z;XXI8DS% G:;% NEFJ:<;S% G:;% 7FDV<:9;S% G:;% J;8D;% N;% JI9NF"% /% RV7LG;% JIGFF<;S% =7% XI:RD9I:%8;FJ987DI98;%F;%D8IG?;%N<Y87N<;S%J78XI9F%N;%X7_I:%:I:%8<?;8F9K=;%e&;:;G?9==;%$38/-((S% 122>f"%%% % 67% 8<J<D9D9I:% N;F% JIGFF<;F% 9:X;RD9;GF;F% ;D% =Z9:X=7MM7D9I:% RV8I:9LG;% 7G% :9?;7G% N;F% K8I:RV;F% RI:NG9F;:D% B% G:;% 9:FGXX9F7:R;% 8;FJ987DI98;% B% =I:Y% D;8M;S% LG9% ;FD% 8;FJI:F7K=;% N;% @2o%N;F%N<R\F"%% % % % % % a3% 8=;=R=8 0JJGDKJGE%FDNGEJDCGE%% 1"3"c"1"3 )-(7>>/('-.!#1'-.23'"/<7!# $;:RI:D8<;% RV;g% A`o% N;F% J7D9;:DFS% =Z9:FGXX9F7:R;% J7:R8<7D9LG;% ;FD% 8;FJI:F7K=;% RV;g% =Z;:X7:D% NG% 8;D78N% FD7DG8ITJI:N<87=% ;D% RV;g% =Z7NG=D;% NG% N<X9R9D% JI:N<87=% 79:F9% LG;% N;% M7=:GD89D9I:%e./HS%122@f"%'==;%;FD%=7%RI:F<LG;:R;%N;%=ZIKFD8GRD9I:%N;F%R7:7G^%;^R8<D;G8F"%6;F% F<R8<D9I:F% J7:R8<7D9LG;F% FI:D% ?9FLG;GF;FS% J7G?8;F% ;:% ;7GS% ;:% K9R78KI:7D;F% ;D% ;:% ;:gEM;F% J7:R8<7D9LG;F"%*=%;:%8<FG=D;%G:%FE:N8hM;%N;%M7=7KFI8JD9I:%N;F%Y879FF;F%F;%M7:9X;FD7:D%J78% G:;% N9788V<;% Y879FF;GF;S% G:;% R78;:R;% ;:% ?9D7M9:;F% =9JIFI=GK=;F% /S% &S% 'S% r% 79:F9% LGZG:;% R78;:R;%;:%7R9N;F%Y87F%;FF;:D9;=F%e./HS%122@f"%% 6;% N97Y:IFD9R% ;FD% M9F% ;:% <?9N;:R;% J78% =;% NIF7Y;% N;% =Z<=7FD7F;% X<R7=;% N7:F% =;F% F;==;F% e=7% :I8M7=;%<D7:D%FGJ<89;G8%B%122%%vYdY%N;%F;==;Ff%e,G8m%$38/-((S%122af"%% % 6Z7DD;9:D;% NG% J7:R8<7F% ;:Y;:N8;% <Y7=;M;:D% G:% N97K\D;% J78% N;FD8GRD9I:% N;F% n=IDF% N;% 67:Y;8V7:F%IG%J78%N<Y<:<8;FR;:R;%Y879FF;GF;S%F;%RIMJ=9LG7:D%:ID7MM;:D%N;%8<D9:IJ7DV9;F% ;D%N;%:<JV8IJ7DV9;F%e./HS%122@f"%% 1"3"c"1"1 B""!/-"!#?31'"%CD/&/'/2!# % 67% J8ID<9:;% )#,$% <D7:D% J8<F;:D;% N7:F% =;F% R;==G=;F% <J9DV<=97=;F% K9=9798;FS% F7% NEFXI:RD9I:% J;GD%J8I?ILG;8%G:;%7GYM;:D7D9I:%N;%=7%?9FRIF9D<%N;%=7%K9=;%;D%G:;%IKFD8GRD9I:%N;F%R7:7G^% K9=9798;F"%6;F%J7D9;:DF%J;G?;:D%]D8;%7DD;9:DF%NZG:;%V<J7DIM<Y7=9;%R988VIY\:;"% % 6;% NIF7Y;% N;F% D87:F7M9:7F;FS% N;% =7% Y7MM7TY=GD7ME=TD87:FX<87F;% exT5,f% ;D% N;F% <RVIY87JV9;F%FI:D%8;RIMM7:N<F%JIG8%=;%N97Y:IFD9R%J8<RIR;%e,G8m%$38/-((S%122af"%%% 6;F%RIMJ=9R7D9I:F%N;%=7%R988VIF;S%VEJ;8D;:F9I:%JI8D7=;%IG%9:FGXX9F7:R;%V<J7DIR;==G=798;S% F;879;:D%8;FJI:F7K=;F%N;%a%B%Ao%N;F%N<R\F%e./HS%122@f"%% % % % % a1% 1"3"c"1"a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e,G8m%$38/-((S%122afS%G:%FE:N8IM;%NZIKFD8GRD9I:% 9:D;FD9:7=;%N9FD7=;S%IG%G:;%RI:FD9J7D9I:%e./HS%122@f"%% % % )V;g%a%:IG?;7GT:<F%FG8%cS%G:%8;X=G^%Y7FD8ITI;FIJV7Y9;:%;FD%N97Y:IFD9LG<%;D%RI:D89KG;% B% =7% N9M9:GD9I:% N;F% J89F;F% 7=9M;:D798;FS% B% =7% N<Y87N7D9I:% N;% =Z<D7D% :GD89D9I::;=% ;D% B% =7% M7OI87D9I:%N;%=7%FEMJDIM7DI=IY9;%8;FJ987DI98;%e,G8m%$38/-((S%122af"% 8=;=R=S 0@JIGE%?>KDMGEJ>JDBKE%ALDKDO@GE%% &G%X79D%N;%=7%Y87:N;%8<J78D9D9I:%R;==G=798;%N;%=7%J8ID<9:;%)#,$S%NZ7GD8;F%I8Y7:;F%J;G?;:D% ]D8;%DIGRV<F%=I8F%N;%=7%MGRI?9FR9NIF;"%% 1"3"c"a"3 E&'-0!(#(70%2/1'2!(## 6;% NEFXI:RD9I::;M;:D% N;% =7% J8ID<9:;% )#,$% ;:D87n:;% =;% M79:D9;:% NZG:;% F<R8<D9I:% N;% FG;G8%89RV;%;:%RV=I8G8;%N;%FIN9GM%;D%;:%;7G"%':%;XX;DS%=;%Y87N9;:D%<=<RD8IRV9M9LG;%7G%:9?;7G% N;% R;F% R;==G=;F% ;FD% 9:?;8F<% J78% 87JJI8D% 7G^% R;==G=;F% K8I:RV9LG;FS% R;% LG9% 8;:N% JIFF9K=;% =7% 8<7=9F7D9I:% NG% D;FD% B% =7% FG;G8"% *=% X7GD% ]D8;% D8\F% ?9Y9=7:D% ;:% R7F% N;% XI8D;F% RV7=;G8FS% R78% R;DD;% J;8D;%N;%F;=%J;GD%;:D87n:;8%G:;%N;FVEN87D9I:%79YGy%JIG?7:D%7?I98%N;%Y87?;F%RI:F<LG;:R;F% e./HS%122@f"%% % % % % aa% 1"3"c"a"1 B""!/-"!#0!#&F'11'2!/&#83-/"'&# @Ao% N;F% VIMM;F% 7DD;9:DF% N;% MGRI?9FR9NIF;% FI:D% FD<89=;F% NG% X79D% NZG:;% 7KF;:R;% K9=7D<87=;%N;%R7:7G^%N<X<8;:DF"%6;F%X;MM;F%J;G?;:D%]D8;%<Y7=;M;:D%7DD;9:D;F%N;%FD<89=9D<%B% R7GF;%NZG:%<J79FF9FF;M;:D%N;%=7%Y=798;%R;8?9R7=;%e./HS%122@f"%% 1"3"c"a"a B""!/-"!(#.'20/'<7!(# 67%J8ID<9:;%)#,$%<D7:D%J8<F;:D;%FG8%=;F%MEIRED;FS%=Z7DD;9:D;%R78N97LG;%J;GD%F;%D87NG98;% J78%N;F%MEIJ7DV9;F"%6;%J=GF%X8<LG;MM;:DS%9=%FZ7Y9D%NZG:;%VEJ;8D;:F9I:%78D<89;==;%JG=MI:798;% F;RI:N798;%B%=Z9:FGXX9F7:R;%8;FJ987DI98;%e./HS%122@f"%% 1"3"c"a"c B""!/-"!(#%("3%'2"/.7&'/2!(## !:;% IFD<IJI8IF;S% NG;% B% G:;% M9:<87=9F7D9I:% IFF;GF;% 9:FGXX9F7:D;% ;D% N;F% 78DV8IJ7DV9;F% FI:D% IKF;8?<;F% RV;g% R;F% J7D9;:DFS% :ID7MM;:D% RV;g% =;F% 7NI=;FR;:DF% ;D% =;F% 7NG=D;F% e./HS% 122@f"%% 1"3"c"a"` B""!/-"!(#G5H# !:;%F9:GF9D;%M7^9==798;%;FD%FIG?;:D%IKF;8?<;S%79:F9%LGZG:;%JI=EJIF;%:7F7=;%X8<LG;:D;%P% 12o%N;F%;:X7:DF%N;%J=GF%N;%`%7:F%e./HS%122@f"% 8=;=: &IDEG%GK%AZ>ING%JZQI>HG@JDO@G% 67% J89F;% ;:% RV78Y;% DV<87J;GD9LG;% N;% =7% MGRI?9FR9NIF;% ;FD% RIMJ=;^;% <D7:D% NI::<;% =7% Y87:N;%N9?;8F9D<%N;%=Z7DD;9:D;%R=9:9LG;"%*=%:ZE%7%M7=V;G8;GF;M;:D%B%R;%OIG8%7GRG:%D879D;M;:D% RG87D9X%<D7K=9"%0:%:;%J;GD%LG;%8;D78N;8%=Z<?I=GD9I:%N;%=7%M7=7N9;%;D%7M<=9I8;8%=7%LG7=9D<%N;%?9;% NG%J7D9;:D"% % % ac% 8=;=:=; &IDEG%GK%AZ>ING%FGE%?>KDMGEJ>JDBKE%H@L?BK>DIGE%% 67% m9:<F9DV<87J9;% 8;FJ987DI98;% ;FD% G:% D879D;M;:D% ;FF;:D9;=% N;% =7% MGRI?9FR9NIF;"% '==;% ;FD% 9:FD7G8<;%D8\F%DhD%N7:F%=;%J8IR;FFGF%N;%J89F;%;:%RV78Y;%NG%J7D9;:D"%':%;XX;DS%;==;%J;8M;D%N;% 8;=7E;8%=;%FEFD\M;%MGRIR9=9798;%;D%N;%N<F;:RIMK8;8%=;F%JIGMI:F%N;F%F<R8<D9I:F%?9FLG;GF;F% LG9% FZE% 7RRGMG=;:D"% 6;% 8EDVM;% N;F% F<7:R;F% N;% m9:<F9DV<87J9;% N<J;:N% N;% =ZkY;% ;D% N;% =Z<D7D% R=9:9LG;%NG%J7D9;:D%P%;==;%?789;%N;%N;G^%XI9F%J78%F;M79:;%B%G:;%B%D8I9F%F<7:R;F%LGID9N9;::;F% e./HS%122@f"%%% % 67% 8VT&+7F;% 8;RIMK9:7:D;% VGM79:;% eIG% -G=MIgEM;zf% ;FD% G:% X=G9N9X97:D% FJ<R9X9LG;% NG% D879D;M;:D% N;% =7% MGRI?9FR9NIF;"% ':% ;XX;DS% ;==;% N9M9:G;% =7% ?9FRIF9D<% N;F% F<R8<D9I:F% ;D% 8<NG9D% =Z;:RIMK8;M;:D%K8I:RV9LG;"%'==;%;FD%8<F;8?<;%7G^%J7D9;:DF%N;%J=GF%N;%`%7:F%e./HS%122@f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eJ89MI9:X;RD9I:S% FG89:X;RD9I:S%RI=I:9F7D9I:f"%':%;XX;DS%JIG8%*30#45(-+-++)"80)%$)"8;D%A0$.-#4'()"8'19()$1B0$D8 G:;%MI:IDV<87J9;%J78%?I9;%I87=;%FGXX9D%Y<:<87=;M;:D"%0:%J;GD%GD9=9F;8%=7%?I9;%J78;:DV<87=;% N7:F% =;F% XI8M;F% F<?\8;F% NZ;^7R;8K7D9I:"% 6;F% 9:X;RD9I:F% J78% 2"$),-.-10"8 0$%)&'1-"08 FI:D% D879D<;F% J=GDhD% J78% ?I9;% 9:D87?;9:;GF;% ;DdIG% 9:V7=<;% 7?;R% JIG8% IKO;RD9X% NZIKD;:98% N;% XI8D;F% RI:R;:D87D9I:F%e.GK;8D%$38/-((S%122a%s%./HS%122@f"% % 6;F% K8I:RVIN9=7D7D;G8F% 9:V7=<F% N;% RIG8D;% IG% =I:YG;% NG8<;% NZ7RD9I:% FI:D% <Y7=;M;:D% FI==9R9D<F"%);%FI:D%Y<:<87=;M;:D%N;F%K]D7T1TM9M<D9LG;F"%% % 6;F% 7:D9T9:X=7MM7DI98;F% :I:% FD<8IQN9;:FS% =;F% RI8D9RIQN;F% J78% ?I9;% I87=;% IG% 9:V7=<F% ;D% =Z7g9DV8IMER9:;% I:D% DIGF% =;F% D8I9F% G:;% 7RD9I:% 7:D9T9:X=7MM7DI98;% LG9% J;GD% ]D8;% 8;RV;8RV<;% N7:F%R;8D79:F%R7F%e./HS%122@f"% % % a`% ':% R7F% NZ9:FGXX9F7:R;% 8;FJ987DI98;% RV8I:9LG;S% =ZI^EY<:IDV<87J9;% ;D% =7% ?;:D9=7D9I:% :I:% 9:?7F9?;%FI:D%:<R;FF798;F%e.GK;8D%$38/-((S%122af"%% % 67% D87:FJ=7:D7D9I:% JG=MI:798;% ;FD% =;% F;G=% 8;RIG8F% ;:% R7F% NZ7DD;9:D;% 8;FJ987DI98;% D;8M9:7=;"% '==;% F;% N9FRGD;% =I8FLG;% =;% CI=GM;% '^J98<% (7^9M7=% J78% H;RI:N;% eC'(Hf% ;FD% 9:X<89;G8% B% a2o% N;% =7% ?7=;G8% DV<I89LG;% ;D% ;:% J8<F;:R;% NZ7GD8;F% F9Y:;F% RIMM;% G:;% VEJI^9;% 7?;R%VEJ;8R7J:9;S%G:;%7:D9K9IN<J;:N7:R;S%G:;%7:D9IK9I8<F9FD7:R;%R8I9FF7:D;%e./HS%122@f"% 8=;=:=8 &IDEG%GK%AZ>ING%FGE%?>KDMGEJ>JDBKE%FDNGEJDCGE%% 67% J89F;% ;:% RV78Y;% :GD89D9I::;==;% ;FD% 9:N9FJ;:F7K=;% RV;g% =;F% J7D9;:DF% 7DD;9:DF% N;% MGRI?9FR9NIF;"%':%;XX;DS%9=F%NI9?;:D%]D8;%FIGM9F%B%G:%8<Y9M;%VEJ;8R7=I89LG;S%VEJ;8J8ID9N9LG;% ;D%:I8MI=9J9N9LG;%e.GK;8D%$38/-((S%122af"%&;F%RIMJ=<M;:DF%;:%?9D7M9:;F%=9JIFI=GK=;F%/S%&S%'S% r%;D%;:%I=9YIT<=<M;:DF%RIMM;%=;%X;8S%g9:RS%F<=<:9GMS%M7Y:<F9GM%J;G?;:D%]D8;%7NM9:9FD8<F%F9% =;F% D7G^% K9I=IY9LG;F% FI:D% X79K=;F"% *=% ;FD% <Y7=;M;:D% 9MJI8D7:D% N;% RI:F;8?;8% G:;% KI::;% VEN87D7D9I:% B% K7F;% N;% FIN9GM% ;D% NZ;7GS% FG8DIGD% ;:% <D<% IG% =I8F% NZG:% ;XXI8D% JVEF9LG;% e./HS% 122@f"%%% % % 6;% D879D;M;:D% N;% =Z9:FGXX9F7:R;% J7:R8<7D9LG;% ;^IR89:;% 8;JIF;% FG8% =7% J8;FR89JD9I:% NZ;^D879DF% J7:R8<7D9LG;F% Y7FD8IT8<F9FD7:DF% e)8<I:zS% 'G8IK9I=zf"% *=F% J;8M;DD;:D% NZ7GYM;:D;8% =Z7JJI8D% ;:% Y879FF;F% ;D% :GD89M;:DFS% ;D% NI:R% ;:% R7=I89;F% ;D% N;% M9;G^% RIG?898% =;F% K;FI9:F% <:;8Y<D9LG;F% e,G8Rm% $38 /-((D% 122a%s% ./HS% 122@f"% 6;% N97K\D;% NI9D% ]D8;% D879D<% J78% 9:FG=9:IDV<87J9;"%% % ':%R7F%NZ7DD;9:D;%V<J7D9LG;S%=Z7R9N;%G8FIN<FI^ERVI=9LG;%e&;=G8F7:zS%!8FI=?7:zf%F;MK=;% 87=;:D98%=Z<?I=GD9I:%?;8F%=7%R988VIF;%e.GK;8D%$38/-((S%122af"% % ':% R7F% N;% N<Y87N7D9I:% N;F% J787M\D8;F% :GD89D9I::;=FS% N;F% RIMJ=<M;:DF% 7=9M;:D798;F% I87G^% FI:D% GD9=9F<F% ;:% J8;M9\8;% 9:D;:D9I:% FG9?9F% J78% G:;% :GD89D9I:% ;:D<87=;% J78% FI:N;% :7FIY7FD89LG;%IG%J78%Y7FD8IFDIM9;%;:%R7F%NZ7YY87?7D9I:%e./HS%122@f"%%% % % ab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`% o% N;% =7% XI:RD9I:% 8;FJ987DI98;% ;:% D8I9F% MI9F% N;% D879D;M;:D% eH;8M;DT57GN;=GF%$38/-((S%1233f"% % &;F%<DGN;F%M;:<;F%FG8%N;F%MI=<RG=;F%9:X=G;:_7:D%=Z7RD9?9D<%N;F%D87:FJI8D;G8F%9I:9LG;F% 7G% :9?;7G% N;% =7% M;MK87:;% 7J9R7=;% N;F% R;==G=;F% K8I:RV9LG;F% NI::;:D% N;F% 8<FG=D7DF% ;:RIG87Y;7:DF"%6;%&G87MER9:zS%G:%J;JD9N;%JI=ERER=9LG;S%M7OI8;%=;%D87:FJI8D%NZ9I:F%RV=I8G8;"% 6;F% <DGN;F% N;% JV7F;% **% I:D% X79D% =7% J8;G?;% N;% FI:% ;XX9R7R9D<% FG8% =7% XI:RD9I:% 8;FJ987DI98;% N\F% LG7D8;%F;M79:;F%N;%D879D;M;:D%eH;8M;DT57GN;=GF%$38/-((S%1233f"% % &Z7GD8;F%<DGN;F%?9F;:D%B%N9M9:G;8%=Z7KFI8JD9I:%;^R;FF9?;%N;%FIN9GM%J78%=;F%R;==G=;F%7G% :9?;7G% 8;FJ987DI98;% LG9% 7% G:% 8h=;% N<=<D\8;% N7:F% =7% M7=7N9;"% 6Z7M9=I89N;% ;:% ;FD% =;% J8IDIDEJ;% M79F%:Z7%LGZG:;%;XX9R7R9D<%D87:F9DI98;"%-TbA2S%N<?;=IJJ<%J78%-789I:%HR9;:R;FT59=;7NS%F;MK=;% ]D8;%J=GF%J8IM;DD;G8%;D%;FD%7RDG;==;M;:D%;:%JV7F;%*%eH;8M;DT57GN;=GF%$38/-((S%1233f"% % 67% DV<87J9;% J8ID<9LG;% 7Y9FF7:D% FG8% =ZI89Y9:;% MI=<RG=798;% N;% =7% M7=7N9;% ;FD% G:;% ?I9;% DV<87J;GD9LG;%;:%RIG8F%NZ<DGN;"%% % % a>% 8=;=V #CBL@JDBK%GJ%HIBKBEJDA% 58kR;%B%=7%M;9==;G8;%RIMJ8<V;:F9I:%N;%=7%M7=7N9;%;D%7G^%7M<=9I87D9I:F%NG%N97Y:IFD9R%;D% NG%N<J9FD7Y;S%=7%FG8?9;%N;F%J7D9;:DF%FZ;FD%RI:F9N<87K=;M;:D%7M<=9I8<;%N;JG9F%=;F%7::<;F%b2"% ':%;XX;DS%7=I8F%LG;%=7%M7OI89D<%N;F%J7D9;:DF%MIG879;:D%7?7:D%`%7:F%;:%3@b2S%=7%?9;%M<N97:;% 7RDG;==;%N<J7FF;%a`%7:F%;D%=Z;FJ<87:R;%N;%?9;%c2%7:Fb"%% % 67%)EFD9R%#9K8IF9F%#IG:N7D9I:%7G^%'D7DFT!:9F%7%<D7K=9%=Z<?I=GD9I:%B%D87?;8F%=;F%7::<;F%N;% =7%FG8?9;%N;F%J7D9;:DF%7DD;9:DF%N;%MGRI?9FR9NIF;"%% % Median Survival Age (Years) 40 36 32 28 24 1986-1990 1991-1995 1996-2000 2001-2005 2006-2010 % % 3DN@IG% [% ^% #CBL@JDBK% FG% L/gNG% ?QFD>K% FG% E@ICDG% FGE% H>JDGKJE% ?@ABCDEADFBEDO@GE% >@b% #J>JEh (KDE%GKJIG%;Y[V%GJ%89;9X% % % 6;% J8I:IFD9R% ?9D7=% ;FD% =9<% 7G^% RIMJ=9R7D9I:F% 7FFIR9<;F% B% =7% MGRI?9FR9NIF;%P% N97K\D;S% R988VIF;S%9:X;RD9I:F%8;FJ987DI98;F%K7RD<89;::;FS%XI:Y9LG;F%;D%9:FGXX9F7:R;%8;FJ987DI98;"%% % %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% b %H9D;%08JV7:;D%P%ppp"I8JV7":;DdFD7D9Rd#$dMGRI?9FR9NIF;"VDM=%e78D9R=;%N;%57K89;=%l;==I:f"% %H9D;%N;%=7%)EFD9R%#9K8IF9F%#IG:N7D9I:%-7D9;:D%$;Y9FD8E%P% VDDJPddppp"RXX"I8Yd!J=I7N;N#9=;Fd69?9:Yi9DV)#d)78;);:D;8+;DpI8md-7D9;:D$;Y9FD8Ed1232T -7D9;:DT$;Y9FD8ET$;JI8D"JNX% % aA% > % &;%J=GFS%=;%:IMK8;%N;%J7D9;:DF%D87:FJ=7:D<F%7GYM;:D;%N;JG9F%3@@AAS%NI::7:D%79:F9%G:% ;FJI98%JIG8%=;%N;?;:98%NG%M7=7N;"%% % 6;%$;Y9FD8;%#87:_79F%N;%=7%(GRI?9FR9NIF;%7%X79D%=;%K9=7:%N;%R;DD;%<?I=GD9I:%P% % INED 140 Nombre de patients 80 74 73 72 74 70 62 60 50 45 39 40 35 30 20 20 30 28 27 23 22 23 22 32 25 10 19 92 19 93 19 94 19 95 19 96 19 97 19 98 19 99 20 00 20 01 20 02 20 03 20 04 20 05 20 06 20 07 20 08 20 09 0 Années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l9=7:%N;F%NI::<;F%122@S%$;Y9FD8;%#87:_79F%N;%=7%(GRI?9FR9NIF;%% VDDJPddppp"?79:R8;=7MGRI"I8Yd;qGJ=I7NdJNXd87JJI8Dq8;Y9FD8;q122@"JNX% @ %l9=7:%N;F%NI::<;F%122@S%$;Y9FD8;%#87:_79F%N;%=7%(GRI?9FR9NIF;%% VDDJPddppp"?79:R8;=7MGRI"I8Yd;qGJ=I7NdJNXd87JJI8Dq8;Y9FD8;q122@"JNX% % % a@% 8=8 ,?HBIJ>KAG% FGE% HBH@L>JDBKE% MBKNDO@GE% P>AJQIDGKKGE%F>KE%L>%?@ABCDEADFBEG% GJ% 8=8=; +GEAIDHJDBK% GJ% IiLG% H>JZBNWKG% FG% L>% ABLBKDE>JDBK% MBKNDO@G%AZGj%LG%H>JDGKJ%>JJGDKJ%FG%?@ABCDEADFBEG% 6;F% 9:X;RD9I:F% 8;FJ987DI98;F% RI:N9D9I::;:D% =7% LG7=9D<% N;% ?9;% ;D% =;% J8I:IFD9R% ?9D7=% N;F% J7D9;:DF%7DD;9:DF%N;%MGRI?9FR9NIF;"%0:%N9FD9:YG;%N;G^%DEJ;F%N;%RI=I:9F7D9I:%N9XX<8;:D;%P%=;F% RV7MJ9Y:I:F%LG9%RI=I:9F;:D%=;F%K8I:RV;F%F7:F%;XX;D%J7DVIY\:;%7JJ78;:D%JIG8%=;%J7D9;:DS%;D% R;G^% LG9% ;^R;8R;:D% G:% JIG?I98% J7DVIY\:;% F;% D87NG9F7:D% J78% N;F% M7:9X;FD7D9I:F% R=9:9LG;FS% M;:7:D% B% N;F% RIMJ=9R7D9I:F% LG9% N<Y87N;:D% =7% XI:RD9I:% JG=MI:798;% eMDN@IG% Yf"% 6Z;FJ\R;% NIM9:7:D;% N;% =7% RI=I:9F7D9I:% XI:Y9LG;% ;FD% !"#$%&'(()"8 9).'&03)"8 8;NIGD<;% JIG8% F;F% RIMJ=9R7D9I:F% R=9:9LG;F"% &Z7GD8;F% ;FJ\R;F% XI:Y9LG;F% I:D% <Y7=;M;:D% G:% 8h=;% J7DVIY\:;% R8I9FF7:D% RIMM;% *+$,-"#-%').8 0#'-"#$%.).S% @E-#4'0(08 ,$%.03'3','"S% !"#$%&'(()"8 3$%%$)"% e69JGM7S% 1232%s% )9MI:% $38 /-((S% 122>f% LG9S% RIMM;% !"#$%&'(()"8 9).'&03)"S% FI:D% N;F% RV7MJ9Y:I:F%X9=7M;:D;G^"%% /01,',080(<'+01"S%=7%=;?G8;%=7%J=GF%X8<LG;:D;%N7:F%=;F%;^J;RDI87D9I:F%N;F%J7D9;:DF%7DD;9:DF%N;% MGRI?9FR9NIF;S% :;% FZ7RRIMJ7Y:;% J7F% N;% M7:9X;FD7D9I:F% R=9:9LG;F% RV;g% =;F% J7D9;:DF% :I:% Y8;XX<F%e)9MI:%$38/-((D%122>f"% % );8D79:;F% ;FJ\R;F% XI:Y9LG;F% I:D% <D<% 9N;:D9X9<;F% RIMM;% RI=I:9F7:D% =;F% ?I9;F% 8;FJ987DI98;F% N;F% J7D9;:DF% 7DD;9:DF% N;% MGRI?9FR9NIF;S% M79F% =;G8% 8h=;% J7DVIY\:;% :Z;FD% J7F% R=798;M;:D% 9N;:D9X9<"% )Z;FD% JIG8LGI9% N;% :IMK8;GF;F% 8;RV;8RV;F% D;:D;:D% NZ<=GR9N;8% =;G8F% RI:F<LG;:R;F%FG8%=7%N<Y87N7D9I:%N;%=7%XI:RD9I:%8;FJ987DI98;"%%% % % % c2% Chronicity A. and non thermophilic Penicillium species Pathogenic potential already demonstrated Pathogenic potential still unknown % % % 3DN@IG% ;9%^% 1Z>?HDNKBKE% MDL>?GKJG@b% >EEBADQE% c% L>% ?@ABCDEADFBEG% AL>EEQE% EGLBK% LG@I% MIQO@GKAG%GJ%LG@I%A>H>ADJQ%c%ABLBKDEGI%AZIBKDO@G?GKJ%LGE%CBDGE%IGEHDI>JBDIGE%_&DZGJ%!"#$%&&]% 899Y`% 8=8=;=; *GE%AZ>?HDNKBKE%MDL>?GKJG@b% 1"1"3"3"3 B(1!28/&&7(#(1I# ! .7K9D7D%;D%R787RD<89FD9LG;F% % -78M9%=;F%3A`%;FJ\R;F%NZ!"#$%&'(()"%8<J;8DI89<;FS%F;G=;M;:D%G:;%?9:YD79:;%NZ;:D8;%;==;F% FI:D% J7DVIY\:;F% JIG8% =Z.IMM;% er89FV:7:% $38 /-((S% 122@f"% 6;F% J=GF% FIG?;:D% 9FI=<;F% FI:D% !;8 9).'&03)"S% !;8 9(0F)"S% !;8 1'&$%S% !;8 1',)(01"S% !;8 3$%%$)"8 NG% X79D% N;% =;G8% ?98G=;:R;S% N;% =;G8% DV;8MI8<F9FD7:R;%;D%N;%=7%N9M;:F9I:%N;%=;G8F%FJI8;F%e5;8M7GN%$38/-((S%122`f"%% % 6;F% !"#$%&'(()"% FI:D% N;F% RV7MJ9Y:I:F% X9=7M;:D;G^% GK9LG9FD;F% J8<F;:DF% 7GFF9% K9;:% ;:% M9=9;G%8G87=%LGZ;:%M9=9;G%G8K79:S%B%=Z9:D<89;G8%IG%B%=Z;^D<89;G8%N;F%V7K9D7D9I:F"%0:%=;F%8;D8IG?;% <Y7=;M;:D%N7:F%=Z;7GS%=;%FI=S%=;F%;:N8I9DF%VGM9N;FS%=;F%N<O;RD9I:F%7?9798;F"%*=F%F;%RIMJI8D;:D% RIMM;%N;F%J7DVIY\:;F%IJJI8DG:9FD;F%N;%=Z.IMM;"% % % c3% ':%#87:R;S%!"#$%&'(()"%;FD%=7%J8;M9\8;%<D9I=IY9;%N;F%MERIF;F%8;FJ987DI98;F%e5;8M7GN%$38 /-((S% 122`f"% *=% ;FD% =;% J=GF% X8<LG;:D% N;F% RV7MJ9Y:I:F% X9=7M;:D;G^% RI=I:9F7:D% =;F% ?I9;F% 8;FJ987DI98;F% N;F% J7D9;:DF% 7DD;9:DF% N;% MGRI?9FR9NIF;"% cbo% N;F% J7D9;:DF% J8<F;:D;:D% B% G:% MIM;:D% NI::<% G:;% RI=I:9F7D9I:% K8I:RV9LG;% J78% !;8 9).'&03)"% e)9MI:% $38 /-((S% 122>f"% 6Z9:X;RD9I:% J78% R;% RV7MJ9Y:I:% DIGRV;% 878;M;:D% =;F% O;G:;F% ;:X7:DF% ;D% F7% J8<?7=;:R;% 7GYM;:D;%7?;R%=ZkY;"%':%;XX;DS%=ZkY;%MIE;:%NZ7JJ789D9I:%NZ!;89).'&03)"%F;%F9DG;%;:D8;%31Sa% 7:F%3cS3%7:F%e)9MI:%$38/-((S%122>%s%69JGM7S%1232f"%8 % H7% XI8D;% R7J7R9D<% N;% FJI8G=7D9I:% ;^J=9LG;% =7% RI:R;:D87D9I:% D8\F% <=;?<;% N;% FJI8;FS% IG% RI:9N9;FS%N7:F%=Z;:?98I::;M;:D"%':%IGD8;%R;F%FJI8;F%8<F9FD;:D%B%N;F%D;MJ<87DG8;F%N;%3`4)%B% `a4)% e6;% lIG8Y;I9F% $38 /-((S% 1233f% R;% LG9% J;8M;D% =;G8% 7RV;M9:;M;:D% OGFLGZ7G^% 7=?<I=;F% JG=MI:798;F%e)8GEJ;::9:RmS%1232f"# % ! )I:D7M9:7D9I:% % 6;F%RI:9N9;F%J78%=;G8%J;D9D;%D79==;%e1%B%aS`%vM%N;%N97M\D8;f%FI:D%RI:FD7MM;:D%9:V7=<;F% J8I?ILG7:D% N;F% RI:F<LG;:R;F% Y87?;F% RV;g% =;F% 9MMG:IN<J89M<F% e67DY<% $38 /-((S% 1223%s% 6;% lIG8Y;I9F%$38/-((S%1233f"%':%;XX;DS%=7%RI:D7M9:7D9I:%J78%!"#$%&'(()"%F;%X79D%J89:R9J7=;M;:D%J78% ?I9;%7<89;::;S%J=GF%878;M;:D%N9Y;FD9?;%P%DV<S%JI9?8;S%X8G9DFS%IG%RGD7:<;%J78%N<JhD%N;%FJI8;F% FG8%=7%J;7G%=<F<;%?97%N;F%J7:F;M;:DF%7NV<F9XF%FIG9==<F%J78%;^;MJ=;%e5;8M7GN%$38/-((S%122`%s% -I989;8S% 122Af"% &;F% 7=D<87=D9I:F% D9FFG=798;F% J8<7=7K=;FS% :ID7MM;:D% N;F% =<F9I:F% <J9DV<=97=;FS% 79:F9% LG;% N;F% 9:X;RD9I:F% K7RD<89;::;F% FI:D% :<R;FF798;F% B% =Z9MJ=7:D7D9I:% N;F% RV7MJ9Y:I:F% N7:F%=;%D87RDGF%8;FJ987DI98;"%% % ! -IG?I98%J7DVIY\:;%% % !;8 9).'&03)"% ;FD% 8;FJI:F7K=;% ;:% Y87:N;% M7OI89D<% N;% =7% J7DVI=IY9;% 7FJ;8Y9==798;% 8;:RI:D8<;%N7:F%=7%MGRI?9FR9NIF;%e)9MI:%$38/-((S%122>f"%6Z9:V7=7D9I:%N;F%FJI8;F%J8I?ILG;%N;% :IMK8;GF;F% RI:F<LG;:R;F% FG8% =;F% ?I9;F% 8;FJ987DI98;% NG% J7D9;:D% 7DD;9:D% N;% MGRI?9FR9NIF;S% RIMM;% N;F% 8<7RD9I:F% NZVEJ;8F;:F9K9=9D<% N;% DEJ;% *% 9MM<N97D;% 8<Y9;% J78% =7% J8INGRD9I:% NZ*MMG:IY=IKG=9:;F% 'S% ***% F;M9T8;D78N<;% IG% *C% 8;D78N<;"% +I8M7=;M;:DS% =;F% FJI8;F% 9:V7=<;F% % % c1% FI:D% <=9M9:<;F% J78% =Z7RD9I:% NG% D7J9F% MGRIR9=9798;S% 79:F9% LG;% J78% =;F% M7R8IJV7Y;FS% =;F% JI=E:GR=<798;F% :;GD8IJV9=;F% ;D% =;F% MI:IRED;F"% );J;:N7:DS% B% R7GF;% N;% X7RD;G8F% =IR7G^% K8I:RVIJG=MI:798;F% X7?I89F7:DF% IG% NZG:% N<X9R9D% 9MMG:9D798;S% =;F% FJI8;F% J;G?;:D% F;% N<?;=IJJ;8%N7:F%=Z7JJ78;9=%8;FJ987DI98;%FIGF%XI8M;%X9=7M;:D;GF;%e5;8M7GN%$38/-((S%122`f"%% % % % 3DN@IG% ;;%^ +DMMQIGKJGE% MBI?GE% ALDKDO@GE% FGE% >EHGINDLLBEGE% PIBKAZBH@L?BK>DIGE% _4GI?>@F% !"#$%&&]%899:`=%% % 6;F%!"#$%&'(()"%FI:D%8;FJI:F7K=;F%N;%LG7D8;%Y87:N;F%J7DVI=IY9;F%P% 8 • !"#$%&'((-"$8<%-1+4-#)(.-10'%$80(($%&'G)$8H8!62!8 % )Z;FD% =7% J7DVI=IY9;% XI:Y9LG;% =7% J=GF% RIMMG:;% ;D% =7% J=GF% 7:R9;::;M;:D% RI::G;% N7:F% =7% MGRI?9FR9NIF;% e)9MI:% $38 /-((D% 122>f"% '==;% DIGRV;% 1% B% 1`o% N;F% J7D9;:DF% ;D% F7% J8<?7=;:R;% FZ<=\?;%B%>SAo%;:%#87:R;"%'D7:D%NI::<%LG;%=Z/l-/%DIGRV;%;FF;:D9;==;M;:D%=;F%7FDVM7D9LG;F% % % ca% ;D%=;F%MGRI?9FR9NIF9LG;FS%=;%8h=;%N;%X7RD;G8F%Y<:<D9LG;F%:Z;FD%J7F%B%;^R=G8;%e6;%lIG8Y;I9F%$38 /-((S% 1233f"% !;8 9).'&03)"% ;FD% =Z;FJ\R;% =7% J=GF% X8<LG;MM;:D% M9F;% ;:% R7GF;% JIG8% R;DD;% J7DVI=IY9;%e)IGDG87GN%$38/-((S%122cf"%% % 6Z/l-/% ;FD% NG;% B% G:;% RI=I:9F7D9I:% K8I:RV9LG;% J78% !"#$%&'(()"S% X7?I89F<;% J78% =;F% 7:IM7=9;F% N;% =7% R=7987:R;% MGRIR9=9798;"% '==;% J8I?ILG;% J78% =7% FG9D;% N;F% 8<7RD9I:F% NZVEJ;8F;:F9K9=9D<% N;% DEJ;% *% 9MM<N97D;% 9:NG9F7:D% =7% =9K<87D9I:% NZ*Y'S% JG9F% ***% F;M9T8;D78N<;% 7?;R% =9K<87D9I:% NZ7:D9RI8JF% J8<R9J9D7:DF% 7:D9T7FJ;8Y9==798;%P% *Y5% e-I989;8S% 122Af"% '==;% FZ7RRIMJ7Y:;% <Y7=;M;:D% NZG:% FE:N8hM;% 9:X=7MM7DI98;% 8;FJI:F7K=;% N;% F<LG;==;F% RIMM;% N;F%K8I:RV;RD7F9;F%eN9=7D7D9I:%N;F%K8I:RV;Ff%IG%G:;%X9K8IF;%e5;8M7GN%$38/-((S%122`f"% % 6Z/l-/% F;% D87NG9D% J89:R9J7=;M;:D% J78% N;F% ;^7R;8K7D9I:F% 8<RG88;:D;F% NZ7FDVM;% RI8D9RI8<F9FD7:DS% N;% =7% DIG^S% N;F% NIG=;G8F% DVI87R9LG;FS% N;F% R87RV7DF% JG8G=;:DFS% N;F% V<MIJDEF9;F"% *=% J;GD% E% 7?I98% <Y7=;M;:D% J8<F;:R;% N;% X9\?8;S% 7:I8;^9;S% R<JV7=<;FS% M7=79F;% e)8GEJ;::9:RmS%1232f"% 6Z<?I=GD9I:%F;%X79D%J78%JIGFF<;F%NZ;^7R;8K7D9I:%e5;8M7GN%$38/-((S%122`f"%HI:%7YY87?7D9I:% ;FD%RIN9X9<;%;:%R9:L%FD7N;F%P% % Biologie Rx I Aigu Ig E totales très augmentées ± éosinophilie sanguine Infiltrats pulmonaires (LS et LM) II Rémission Ig E totales normales ou augmentées Pas d’infiltrats sans corticoïdes oraux depuis > 6 mois III Exacerbation Ig E totales très augmentées ± éosinophilie sanguine Infiltrats pulmonaires (LS et LM) IV Asthme corticodépendant Ig E totales normales ou augmentées Avec ou sans infiltrats V Fibrose Ig E totales normales ou augmentées Fibrose, bronchectasies, lésions bulleuses % 3DN@IG%;8%^%1L>EEDMDA>JDBK%FGE%EJ>FGE%F/0<&0%_*G%<B@INGBDE%!"#$%&&]%89;;`=% % % cc% 6;%N97Y:IFD9R%8;JIF;%FG8%=;%D;FD%RGD7:<%9MM<N97DS%N;F%*Y'%B%!"#$%&'(()"%JIF9D9?;FS%N;F%*Y'% DID7=;F% ;D% N;F% J8<R9J9D9:;F% 7:D9T7FJ;8Y9==798;F% 7GYM;:D<;F"% &Z7GD8;F% J787M\D8;F% 9:RI:FD7:DF% J;G?;:D% ]D8;% M9F% ;:% <?9N;:R;% =I8F% NZG:;% ;^7R;8K7D9I:%P% G:;% J8<F;:R;% NZ*Y5% 7:D9T 7FJ;8Y9==798;F%N<D;RD<;%J78%'6*H/S%G:;%VEJ;8<IF9:IJV9=9;%F7:YG9:;S%=Z9FI=;M;:D%NZ!"#$%&'(()" N7:F%=Z;^J;RDI87D9I:%e5;8M7GN%$38/-((S%122`f"% % 6;%M;9==;G8%D879D;M;:D%8;FD;%=7%RI8D9RIDV<87J9;%J78%?I9;%I87=;%7FFIR9<;%B%G:%D879D;M;:D% 7:D9XI:Y9LG;%P% 9D87RI:7gI=;% eHJI87:I^zfS% ?I89RI:7gI=;% eCX;:Nzf% IG% JIF7RI:7gI=;% e+I^7X9=zf% ;:% R7F% N;% 8<F9FD7:R;S% LG9% J;8M;DD879D% G:% F;?87Y;% J=GF% 87J9N;% ;D% N9M9:G;879D% =;F% 8;RVGD;F% B% =Z788]D%NG%D879D;M;:D%e)9MI:%$38/-((D%122>%s%6;%lIG8Y;I9F%$38/-((S%1233f"% % • !"#$%&'((-"$8#)(.-10'%$8+4%-1'G)$81C+%-"013$8 % 'Y7=;M;:D%7JJ;=<;%7FJ;8Y9==IF;%JG=MI:798;%F;M9T9:?7F9?;S%;==;%<?I=G;%9:F9N9;GF;M;:D%FG8% J=GF9;G8F%MI9F"%6;F%X9=7M;:DF%XI:Y9LG;F%;:?7V9FF;:D%=;%J78;:RVEM;%;D%J8I?ILG;:D%N;F%J=7Y;F% N;%:<R8IF;%;D%G:;%9:X=7MM7D9I:%RV8I:9LG;"%*=%7JJ787nD%R=9:9LG;M;:D%G:;%DIG^%J8INGRD9?;S%N;% =7%X9\?8;%;D%G:;%7=D<87D9I:%N;%=Z<D7D%Y<:<87="%% % % 6;% N97Y:IFD9R% F;% 8<?\=;% JIF9D9X% FG8% ;^7M;:% NZG:;% K9IJF9;% JG=MI:798;% IG% M9F;% ;:% <?9N;:R;% N;% =7% J8<F;:R;% NZ!"#$%&'(()"% N7:F% =Z;^J;RDI87D9I:% IG% N7:F% =;% =7?7Y;% K8I:RVI7=?<I=798;"% 67% F<8I=IY9;% 7FJ;8Y9==798;% ;FD% FIG?;:D% JIF9D9?;% e5;8M7GN% $38 /-((S% 122`%s% )IGDG87GN%$38/-((S%122cf"%% 8 • 6%-1+4'3$80"#$%&'((0'%$88 % 67% K8I:RV9D;% 7FJ;8Y9==798;% :Z;FD% J7F% X8<LG;:D;"% '==;% 7FFIR9;% G:% D7K=;7G% N;% FG89:X;RD9I:% K8I:RV9LG;%B%N;F%F9K9=7:R;FS%G:;%VEJ;8DV;8M9;S%G:;%NEFJ:<;S%N;F%NIG=;G8F%DVI87R9LG;FS%N;F% V<MIJDEF9;FS%N;F%;^J;RDI87D9I:F"%'==;%J;GD%]D8;%7FDVM7D9XI8M;%N7:F%R;8D79:F%R7F"%%% 67% F<8I=IY9;S% =;% NIF7Y;% N;F% *Y'% ;D% =;% D7G^% NZ<IF9:IJV9=;F% F7:YG9:F% FI:D% :I8M7G^% e5;8M7GN%$38/-((S%122`%s%)IGDG87GN%$38/-((S%122cf"%% % % % c`% • !"#$%&'((-"$8#)(.-10'%$8'1F0"'F$8H8!2I8 % )Z;FD% G:;% RIMJ=9R7D9I:% 9:X;RD9;GF;% M7O;G8;% N;% =Z9MMG:IN<J89M<S% 8;FJI:F7K=;% NZG:;% MI8D7=9D<%FGJ<89;G8;%B%`2o%e5;8M7GN%$38/-((S%122`f"%'==;%;FD%8;NIGD<;%J78D9RG=9\8;M;:D%RV;g% =;F% J7D9;:DF% :;GD8IJ<:9LG;FS% =;F% J7D9;:DF% Y8;XX<F% B% R7GF;% N;F% D879D;M;:DF% 9MMG:IFGJJ8;FF;G8FS% =;F% J7D9;:DF% JI8D;G8F% NG% C*."% 6;F% FJI8;F% 7FJ;8Y9==798;F% 9:V7=<;F% F;% N<?;=IJJ;:D% 7G% :9?;7G% K8I:RV9LG;% FIGF% XI8M;% X9=7M;:D;GF;"% );F% X9=7M;:DF% FI:D% 8;FJI:F7K=;F% NZG:;% :<R8IF;% K8I:RV9LG;% ;D% N;% =Z;:?7V9FF;M;:D% NG% J78;:RVEM;% N;% =Z78D\8;% JG=MI:798;" *=F%?I:D%;:D87n:;8%G:;%DV8IMKIF;%78D<89;==;%;D%G:%9:X78RDGF%JG=MI:798;%JG9F%9=F%F;% J8IJ7Y;:D% ?;8F% NZ7GD8;F% I8Y7:;F% D;=F% LG;% =7% J;7GS% =;F% IFS% =;% R;8?;7GS% =;% R[G8% e5;8M7GN% $38 /-((S%122`f"% % 67%F<M9I=IY9;%R=9:9LG;%F;%D87NG9D%J78%N;F%NIG=;G8F%DVI87R9LG;FS%G:;%X9\?8;%8<F9FD7:D;%7G^% 7:D9K9ID9LG;FS%G:;%NEFJ:<;%;D%N;F%V<MIJDEF9;F"%% % 67% K9IJF9;% JG=MI:798;% J;8M;D% G:% N97Y:IFD9R% N;% R;8D9DGN;% M79F% :Z;FD% 8<7=9F<;% LG;% 878;M;:D% RV;g% R;F% J7D9;:DF% B% V7GDF% 89FLG;F"% 6;% N97Y:IFD9R% JI8D;% NI:R% FG8% =7% DIMIN;:F9DIM<D89;% LG9% M;D% ;:% <?9N;:R;% =;% t%F9Y:;% NG% V7=I%u% J8<RIR;S% ;D% =;% F9Y:;% NG% t%R8I9FF7:D%Y7g;G^%u%LG9:g;%OIG8F%J=GF%D78N%e5;8M7GN%$38/-((S%122`f"%/G%:9?;7G%K9I=IY9LG;S%=7% N<D;RD9I:%NZG:;%7:D9Y<:<M9;%7FJ;8Y9==798;%;FD%G:%78YGM;:D%N97Y:IFD9R%9MJI8D7:D"%% % % l9;:%LG;%MI9:F%X8<LG;MM;:D%9MJ=9LG<S%!;83$%%$)"%F;MK=;%R;J;:N7:D%]D8;%G:%J7DVIY\:;% 9MJI8D7:D% N7:F% =;% R7N8;% N;% =7% MGRI?9FR9NIF;"% ':% ;XX;DS% 9=% ;FD% FIG?;:D% 8;FJI:F7K=;% NZG:;% RI=I:9F7D9I:% RV8I:9LG;% RV;g% R;F% J7D9;:DF% e-9V;D% $38 /-((S% 122@f"% H7% X8<LG;:R;% ;FD% ;FD9M<;% B% bS1o%J78%)9MI:%$38/-((%e)9MI:%$38/-((S%122>f"%*=%F;879D%9MJ=9LG<%N7:F%=;F%/l-/32%79:F9%LG;%N7:F% N;F%R7F%NZ7FJ;8Y9==IF;%JG=MI:798;%9:?7F9?;%e-I989;8S%122A%s%-9V;D%$38/-((S%122@f"%% 8 %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 32 % % %9FI=<%RI:OI9:D;M;:D%7?;R%!;89).'&03)"% cb% !;89(0F)"S%D8\F%J8<F;:D%<Y7=;M;:D%N7:F%=7%:7DG8;S%FZ7?\8;%]D8;%G:%8;NIGD7K=;%J7DVIY\:;% RV;g%=;F%9MMG:IN<J89M<F"%':%;XX;DS%R;DD;%;FJ\R;%X9=7M;:D;GF;%F;879D%B%=ZI89Y9:;%N;%32o%N;F% 9:X;RD9I:F% K8I:RVIJ=GMI:798;FS% :ID7MM;:D% N7:F% =;F% 7FJ;8Y9==IF;F% JG=MI:798;F% 9:?7F9?;F% er89FV:7:%$38/-((S%122@f"% 1"1"3"3"1 J.!0%(1%2/7:#(1I# ! .7K9D7D%;D%R787RD<89FD9LG;F% % )9:L% ;FJ\R;F% RI:FD9DG;:D% =;% Y;:8;% *+$,-"#-%').%P% *;8 0#'-"#$%.).S8 2"$),-0(($"+4$%'08 <-5,''S% *;8 #%-('9'+01"S% *;8 0)%013'0+).S% *;8 ,$4--&''"% H;G=F% *;8 0#'-"#$%.).J2;8 <-5,''% ;D% *;8 #%-('9'+01"%I:D%<D<%N<R89DF%RIMM;%J7DVIY\:;F%IJJI8DG:9FD;F%N;F%VhD;F%9MMG:IN<J89M<F%;D% RV;g% =;F% J7D9;:DF% 7DD;9:DF% N;% MGRI?9FR9NIF;"% );J;:N7:DS% N7:F% G:;% <DGN;% 7GFD87=9;::;% 8<R;:D;S% *;8 0)%013'0+).% 7% <D<% 9N;:D9X9<% RIMM;% G:% J7DVIY\:;% 9MJI8D7:DS% 7E7:D% G:;% X8<LG;:R;%<=;?<;%J78M9%=;F%J7D9;:DF%N7:F%R;%J7EF%el=EDV%$38/-((S%1232Kf"% 8 *;80#'-"#$%.).%;FD%9N;:D9X9<%RIMM;%=;%RV7MJ9Y:I:%X9=7M;:D;G^%=;%J=GF%X8<LG;:D%RV;g% =;F% MGRI?9FR9NIF9LG;F% 7J8\F% !;8 9).'&03)"% % e69JGM7S% 1232f% 7GLG;=% 9=% ;FD% =9<"% ':% ;XX;DS% *;8 0#'-"#$%.).%;FD%9FI=<%N7:F%=;F%F<R8<D9I:F%8;FJ987DI98;F%;:%M]M;%D;MJF%LG;%!;89).'&03)"S% IG%7J8\F%=7%RI=I:9F7D9I:%J78%R;=G9TR9%e-9V;D%$38/-((S%122@f"%H7%J8<?7=;:R;%F;879D%;FD9M<;%;:D8;%A% ;D% 32o% e)9MI:% $38 /-((S% 122>f"% ':% IGD8;D8 *;8 0#'-"#$%.).% :;% DIGRV;% J7F% =;F% O;G:;F% ;:X7:DF"% &Z7J8\F% G:;% <DGN;% M;:<;% J78% )9MI:% $38 /-((% ;:% 1222S% =ZkY;% MIE;:% N;% =Z9FI=;M;:D% N;% R;% RV7MJ9Y:I:%;FD%N;%3cS`%7:F"%% % );% FI:D% N;F% RV7MJ9Y:I:F% X9=7M;:D;G^% F7J8IJVED;F% F;% N<?;=IJJ7:D% N7:F% =7% :7DG8;S% :ID7MM;:D% =;F% FI=FS% =Z;7GS% =;F% XGM9;8F"% 6;F% J=7:D;F% ;:% JID% FI:D% <Y7=;M;:D% J89F<;F% J78% R;% RV7MJ9Y:I:"% '==;F% RI:FD9DG;:D% J78% RI:F<LG;:D% G:% X7RD;G8% N;% 89FLG;% 9MJI8D7:D% JIG8% =;F% J7D9;:DF%7DD;9:DF%N;%MGRI?9FR9NIF;%e-9V;D8$38/-((S%122@f"%% % % % % % c>% ! )I:D7M9:7D9I:% % 67%RI:D7M9:7D9I:%J78%*+$,-"#-%').%F;%X79D%J78%9:V7=7D9I:%8;FJ987DI98;%N;%FJI8;F%IG%FG9D;% B% G:;% ;XX87RD9I:% RGD7:<;"% 6Z7Y87:G=IREDIF;% ;D% =7% RI8D9RIDV<87J9;% 7G% =I:Y% RIG8F% RI:FD9DG;:D% N;F% X7RD;G8F% N;% 89FLG;% J89:R9J7G^% e-I989;8S% 122Af"% &;% J=GFS% 9=% F;MK=;879D% LG;% =Z;^9FD;:R;% NZ7=D<87D9I:F%J8<7=7K=;F%NG%D87RDGF%8;FJ987DI98;%RV;g%=;%J7D9;:D%X7R9=9D;%=7%RI=I:9F7D9I:%J78%*;8 0#'-"#$%.).%e)9MI:%$38/-((S%1222f"%% % ! -IG?I98%J7DVIY\:;% % 6;F% ;FJ\R;F% NG% Y;:8;% *+$,-"#-%').% FI:D% 8<F9FD7:D;F% B% N;% :IMK8;G^% 7:D9XI:Y9LG;FS% R;% LG9% ;:D87n:;% G:;% RI:D8;T9:N9R7D9I:% 8;=7D9?;% B% =7% D87:FJ=7:D7D9I:% FZ9=% E% 7% RI=I:9F7D9I:% J78% R;% RV7MJ9Y:I:%el=EDV%$38/-((D%12327f"%*;80#'-"#$%.).%RI:D89KG;%F7:F%7GRG:%NIGD;%B%=7%8<7RD9I:% 9:X=7MM7DI98;%;D%B%=7%N<Y87N7D9I:%J8IY8;FF9?;%N;%=7%XI:RD9I:%JG=MI:798;%e-9V;D%$38/-((S%122@f"% *;8 0#'-"#$%.).S% :ID7MM;:D% 9MJ=9LG<% N7:F% N;F% R7F% N;% MER<DIM;% eDGM;G8% 9:X=7MM7DI98;f% ;:% N;VI8F% N;% =7% MGRI?9FR9NIF;S% 7% DIGD;XI9F% <D<% 9MJ=9LG<% N7:F% LG;=LG;F% R7F% N;% MERIF;F% K8I:RVITJG=MI:798;F% 7==;8Y9LG;F"% 6;% D7K=;7G% R=9:9LG;% ;FD% F;MK=7K=;% B% R;=G9% N;% =Z/l-/S% B% =7% N9XX<8;:R;% FG9?7:D;%P% *;8 0#'-"#$%.).% ;FD% =Z7Y;:D% XI:Y9LG;% 9FI=<% N7:F% =;F% F<R8<D9I:F% K8I:RV9LG;F% ;D% =7% F<8I=IY9;% ;FD% XI8D;M;:D% JIF9D9?;% 7?;R% M9F;% ;:% <?9N;:R;% N;% J8<R9J9D9:;F% F<89LG;F%7:D9T*;0#'-"#$%.).%e)9MI:%$38/-((S%122>f"%&;%J=GFS%9=%7%<D<%<?ILG<%LG;%=;F%J7D9;:DF% RI=I:9F<F%J78%R;%RV7MJ9Y:I:%7G879;:D%G:%89FLG;%F9Y:9X9R7D9?;M;:D%J=GF%<=;?<%NZ]D8;%?9RD9M;% NZG:;%/l-/%e-7GY7M%$38/-((S%1232f"% *;8 0#'-"#$%.).% J;GD% ]D8;% 8;FJI:F7K=;% N;% MERIF;F% R<8<K87=;F% IG% N9FF<M9:<;F% RV;g% =;F% J7D9;:DF%9MMG:IN<J89M<F%e-9V;D%$38/-((S%122@f"% &;F% R7F% N;% FR<NIFJI89IF;F% FEFD<M9LG;F% FIG?;:D% MI8D;==;FS% 7?;R% 7DD;9:D;F% JG=MI:798;F% ;D% :;G8I=IY9LG;F% I:D% <D<% 87JJI8D<;F% RV;g% =;F% J7D9;:DF% Y8;XX<F"% 67% RI=I:9F7D9I:% J78% =;F% *+$,-"#-%').% F;MK=;% ]D8;% G:% X7RD;G8% N;% 89FLG;% 7G^% J7DVI=IY9;F% 9:?7F9?;F% 7J8\F% D87:FJ=7:D7D9I:S%J8I?ILG7:D%G:;%XI8D;%MI8D7=9D<%el=EDV%$38/-((D%12327f"%*=%7%<D<%J8IJIF<%J78% RI:F<LG;:D%NZ9:FD7G8;8%7?7:D%D87:FJ=7:D7D9I:%G:%D879D;M;:D%7:D9XI:Y9LG;%7X9:%N;%J8<?;:98%=7% FG8?;:G;%NZG:;%FR<NIFJI89IF;%9:?7F9?;%7J8\F%Y8;XX;%e)9MI:%$38/-((S%122>f"%% 8 % % cA% *;8 #%-('9'+01"% J;GD% ]D8;% <Y7=;M;:D% 8;FJI:F7K=;% NZ9:X;RD9I:F% J8IXI:N;F% N7:F% =7% J<89IN;% JIFDTY8;XX;"% ':% N;VI8F% N;% R;% RI:D;^D;S% 9=% ;FD% 8;FJI:F7K=;% N7:F% =7% MGRI?9FR9NIF;% N;% =7% RI=I:9F7D9I:%N;F%?I9;F%8;FJ987DI98;FS%Y<:<87=;M;:D%D87:F9DI98;%;D%7FEMJDIM7D9LG;%e)9MI:%$38 /-((S%122>f"%% 1"1"3"3"a B7"2!(#.?':1/8-%-(#>/&':!-"!7K# ! @E-#4'('08,$%.03'3','"8 8 );%RV7MJ9Y:I:%X9=7M;:D;G^%F7J8IJVED;S%J8<F;:D%N7:F%=7%:7DG8;S%J;GD%FG8?9?8;%N;F%MI9F% N7:F%G:%;:?98I::;M;:D%RV7GN%;D%VGM9N;S%J78%;^;MJ=;%=;F%F7G:7FS%=;F%F7==;F%N;%K79:S%R;%LG9% ;^J=9LG;%F7%XI8D;%J8<F;:R;%;:%HG\N;%J78%;^;MJ=;%%e69JGM7S%1232%s%6;K;RLG;% $38/-((S%1232S% rI:NI89%$38/-((D%1233f"%% HI:%D7G^%NZ9FI=;M;:D%?789;%N;%3SA%B%3`S>o%F;=I:%=;F%<DGN;F%N7:F%=;%R7N8;%N;%=7%MGRI?9FR9NIF;% e-I989;8S%122Af"%% % );% RV7MJ9Y:I:% ;FD% B% =ZI89Y9:;% N;% MERIF;F% FIGFTRGD7:<;F% JIFDTD87GM7D9LG;F% ;D% N;% LG;=LG;F% R7F% NZ7DD;9:D;F% ?9FR<87=;FS% JG=MI:798;F% ;D% :;G8I=IY9LG;F% e)9MI:% $38 /-((S% 122>f"% &7:F% =;% R7N8;% N;% =7% MGRI?9FR9NIF;S% 9=% ;FD% R7J7K=;% N;% RI=I:9F;8% =;F% ?I9;F% 8;FJ987DI98;F% ;D% NZ9:NG98;%G:;%8<JI:F;%F<8I=IY9LG;%FJ<R9X9LG;%e6;K;RLG;%$38/-((S%1232f"%);DD;%RI=I:9F7D9I:%;FD% D87:F9DI98;% IG% RV8I:9LG;% ;D% J;GD% J8I?ILG;8% N;F% 9:X;RD9I:F% 8;FJ987DI98;F% IG% N;F% 9:X;RD9I:F% XI:Y9LG;F%9:?7F9?;F%e-9V;D%$38/-((S%122@%s%lIGRV787%$38/-((S%122@f"%%% % 67%RI=I:9F7D9I:%J78%!;89).'&03)"%;D%=;%Y<:IDEJ;%N#`2AdN#`2A%F;MK=;:D%]D8;%N;F%X7RD;G8F% N;%J8<N9FJIF9D9I:%e6;K;RLG;%$38/-((S%1232f"%&Z7J8\F%=;G8%<DGN;%J78G;%;:%1233S%rI:NI89%$38/-((% N<MI:D8;:D% LG;% @;8 ,$%.03'3','"% ;FD% F9Y:9X9R7D9?;M;:D% 7FFIR9<% B% =Z9:FGXX9F7:R;% J7:R8<7D9LG;% eJ{2S23f%;D%RI:X98M;:D%FI:%7FFIR97D9I:%7?;R%!;89).'&03)""%% % % % % % % c@% ! !+%-#4'0(-#4-%089)"'#-%0% % )Z;FD%G:%RV7MJ9Y:I:%DV;8MI8<F9FD7:DS%J8<F;:D%N7:F%=;%FI="%H;G=;M;:D%VG9D%R7F%I:D%<D<% 8;JI8D<F%P%D8I9F%R7F%N;%m<87D9D;FS%D8I9F%R7F%NZ9:X;RD9I:F%JG=MI:798;FS%G:%R7F%NZ7KR\F%R<8<K87=S% G:%R7F%G:9LG;%RV;g%G:%J7D9;:D%;FJ7Y:I=%7DD;9:D%N;%MGRI?9FR9NIF;"%67%RI=I:9F7D9I:%RV;g%R;=G9T R9%<D79D%D87:F9DI98;"%);J;:N7:D%R;F%N;8:9\8;F%7::<;FS%LG;=LG;F%R7F%I:D%<D<%N<R89DF%;:%#87:R;"% 67%N<D;RD9I:%N;%R;%RV7MJ9Y:I:%N7:F%=;F%F<R8<D9I:F%8;FJ987DI98;F%7%FG9?9%=7%RI=I:9F7D9I:%J78%!;8 9).'&03)""% (79F% NG87:D% R;DD;% RI=I:9F7D9I:S% 7GRG:% F9Y:;% R=9:9LG;% NZ9:X;RD9I:% K8I:RVIJG=MI:798;%:;%XGD%8;=;?<"%% 67% J8<?7=;:R;% N;% R;% RV7MJ9Y:I:% ;FD% NI:R% D8\F% X79K=;"% +<7:MI9:F% ;==;% ;FD% J;GD% ]D8;% FIGF% ;FD9M<;%RIMJD;%D;:G%NG%M7:LG;%N;%RI::79FF7:R;%e-9V;D%$38/-((S%122@f"% % ! 2$1'+'((').8"#;8 % 6;F% 2$1'+'((').% FI:D% N;F% RV7MJ9Y:I:F% F7J8IJVED;F% B% =ZI89Y9:;% N;% =7% N<Y87N7D9I:% N;F% N;:8<;F% 7=9M;:D798;F"% *=F% FI:D% J8<F;:DF% ;:% 7KI:N7:R;% N7:F% =;% FI=% ;D% =Z798S% 7GFF9% K9;:% B% =Z;^D<89;G8% LGZB% =Z9:D<89;G8% e-I989;8S% 122Af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e5987GN%$38/-((S%1232f"%% % % % `2% &;JG9F%3@@@S%3>%R7F%N;%RI=I:9F7D9I:%J78%:;80%&'((0+$0%I:D%<D<%87JJI8D<F"%/RDG;==;M;:DS%9=% :;% F;MK=;% J7F% LG;% =7% RI=I:9F7D9I:% XI:Y9LG;% J78% R;DD;% ;FJ\R;% FI9D% 7FFIR9<;% B% G:;% ;^7R;8K7D9I:% N;% =7% M7=7N9;"% );J;:N7:DS% <D7:D% NI::<% =;F% J8IJ89<D<F% DV;8MIJV9=;F% N;% R;% RV7MJ9Y:I:S% 9=% JIG8879D% ]D8;% R7:N9N7D% JIG8% J8I?ILG;8% N;F% J7DVI=IY9;F% 9:?7F9?;F% RV;g% =;F% 9MMG:IN<J89M<F% % :ID7MM;:D% 7J8\F% D87:FJ=7:D7D9I:% JG=MI:798;S% RIMM;% J8<R<N;MM;:D% 87JJI8D<%JIG8%*;80#'-"#$%.).%e5987GN%$38/-((S%1232f"%% 8=8=;=8 *GE%LGC@IGE%% 1"1"3"1"3 $'-0/0'#(1I# 6;% Y;:8;% /01,',08 8;Y8IGJ;% N;% :IMK8;GF;F% ;FJ\R;F"% 6;F% J=GF% RIMMG:;F% FI:D% /;8 0(<'+01"D8/;8&(0<%030D8/;87%)"$'D8/;8#0%0#"'(-"'"%;D%/;83%-#'+0('";%% 6;F% /01,',0% FI:D% N;F% ;FJ\R;F% XI:Y9LG;F% F7J8IJVED;F% N;% =7% J;7G% ;D% N;F% MGLG;GF;F% RV;g% =Z.IMM;S%M79F%<Y7=;M;:D%NG%FI=%;D%N;F%?<Y<D7G^"%/;80(<'+01"%;FD%G:;%=;?G8;%RIMM;:F7=;%N;F% R7?9D<F% :7DG8;==;F"% &7:F% =7% MGRI?9FR9NIF;S% =7% RI=I:9F7D9I:% N;% =Z78K8;% K8I:RV9LG;% F;% X79D% J78% ?I9;%;:NIY\:;%=I8F%N;%RI:N9D9I:F%=IR7=;F%X7?I89F7:D;F%e-I989;8S%122Af"%% 8 /;80(<'+01"%;FD%9FI=<%B%N;F%X8<LG;:R;F%?7897:D%N;%`b%B%>`o%F;=I:%=;F%<DGN;F%;D%8;J8<F;:D;% =Z;FJ\R;%M7OI89D798;%N7:F%=;F%;^J;RDI87D9I:F%N;F%J7D9;:DF%7DD;9:DF%N;%MGRI?9FR9NIF;%e)9MI:% $38 /-((S% 122>f"% (7=Y8<% R;DD;% XI8D;% RI=I:9F7D9I:S% I:% IKF;8?;% D8\F% 878;M;:D% N;F% 9:X;RD9I:F% R7:N9NIF9LG;F% RV;g% R;F% J7D9;:DF"% );=7% FZ;^J=9LG;879D% J78% =Z7RD9?9D<% 7:D9XI:Y9LG;% N;% R;8D79:;F% K7RD<89;F% RI=I:9F7:D% =;F% ?I9;F% 8;FJ987DI98;F% e)VID98M7==% $38 /-((S% 1232f"% );F% 9:X;RD9I:F% FI:D% NG;F% =;% J=GF% FIG?;:D% B% /;0(<'+01"% ;D% F;% N;?;=IJJ;:D% FIGF% XI8M;% NZ9:X;RD9I:F% FEFD<M9LG;F% F<?\8;FS%J78D9RG=9\8;M;:D%;:%J<89IN;%JIFDTY8;XX;%e)9MI:%$38/-((S%122>f"%);8D79:F%RV;8RV;G8F% <M;DD;:D%=ZVEJIDV\F;%LG;%=7%J8<F;:R;%N;%/;80(<'+01"%N7:F%=Z;^J;RDI87D9I:%;FD%7FFIR9<;%B%G:;% Y87?9D<% Y=IK7=;% J=GF% 9MJI8D7:D;S% M]M;% F9% =;F% N9XX<8;:R;F% IKF;8?<;F% ;:% D;8M;% NZ7DD;9:D;% 8;FJ987DI98;%8;FD;:D%:I:%F9Y:9X9R7D9?;F%e58G:N;8K;;Rm%$38/-((S%1232f"%% %&;% J=GFS% =;% 89FLG;% NZG:;% RI=I:9F7D9I:% J78% /01,',0% 7GYM;:D;% B% R7GF;% N;% =ZGF7Y;% N;F% RI8D9RIQN;F%9:V7=<FS%NZ7:D9K9ID9LG;F%7G%=I:Y%RIG8F%;D%NZG:%N97K\D;%e)VID98M7==%$38/-((D%1232%s% % % `3% )9MI:%$38/-((S%122>f"%2"$),-.-10"80$%)&'1-"0%F;879D%<Y7=;M;:D%7FFIR9<%B%=7%J8<F;:R;%N;%/;8 0(<'+01"%e)VID98M7==%$38/-((S%1232%s%iV9DD7m;8%6;R=798%$38/-((S%1232f"%% 8 /01,',08 ,)<('1'$1"'"S% NI:D% =7% J8<?7=;:R;% RV;g% =;F% J7D9;:DF% MGRI?9FR9NIF9LG;F% J;GD% 7DD;9:N8;%33S3o%7%<Y7=;M;:D%<D<%N<R89D%RIMM;%8;FJI:F7K=;%NZ9:X;RD9I:%J8IXI:N;%X7D7=;%RV;g% G:%J7D9;:D%7J8\F%Y8;XX;%K9JG=MI:798;%e)9MI:%$38/-((S%122>f"%% 1"1"3"1"1 B7"2!(#&!972!(## );8D79:;F% =;?G8;F% NG% Y;:8;% K%'+4-,$%.08 IG8 *0++40%-.5+$"8 +$%$F'"'0$8 FI:D% <Y7=;M;:D% J8<F;:D;F%N7:F%=;F%?I9;F%8;FJ987DI98;F%N;F%J7D9;:DF%7DD;9:DF%N;%MGRI?9FR9NIF;"%6;G8%JIG?I98% J7DVIY\:;%N7:F%R;DD;%M7=7N9;%:Z7%J7F%<D<%N<MI:D8<%B%R;%OIG8"%% 8=8=8 +GEAIDHJDBK%GJ%IiLG%H>JZBNWKG%FGE%P>AJQIDGE%AZGj%LG% H>JDGKJ%>JJGDKJ%FG%?@ABCDEADFBEG% 67%RI=I:9F7D9I:%N;F%?I9;F%7<89;::;F%J78%=;F%K7RD<89;F%IRRGJ;%G:;%J=7R;%9MJI8D7:D;%N7:F% R;DD;%J7DVI=IY9;%;D%RI:D89KG;%B%=7%N<Y87N7D9I:%N;%=7%XI:RD9I:%JG=MI:798;"%6;F%N;G^%Y;8M;F% =;F% J=GF% X8<LG;MM;:D% 9FI=<F% FI:D% *30#45(-+-++)"8 0)%$)"% ;D% 2"$),-.-10"8 0$%)&'1-"0"% );% N;8:9;8% F9Y:;% G:;% 7YY87?7D9I:% N;% =7% M7=7N9;"% );J;:N7:DS% NZ7GD8;F% K7RD<89;F% I:D% <Y7=;M;:D% G:% 8h=;% N7:F% R;DD;% RI=I:9F7D9I:% RIMM;% A0$.-#4'()"8 '19()$1B0$S% *3$1-3%-#4-.-10"8 .0(3-#4'('0%IG%J=GF%878;M;:D%6)%74-(,$%'08+$#0+'0"%% % 6;%$;Y9FD8;%#87:_79F%N;%=7%(GRI?9FR9NIF;%7%<D7K=9%G:%Y87JV9LG;%J;8M;DD7:D%N;%RI88<=;8% =ZkY;%;D%=7%RI=I:9F7D9I:%K7RD<89;::;%P%% % % % % % `1% INED 13411 Pourcentage 100 90 80 P. aeruginosa
  
  70
  60
  
  S. aureus méti S
  
  50
  40
  30
  
  H. influenzae
  
  20
  S. aureus méti R
  10
  
  S. maltophilia
  B. cepacia
  
  0
  0-4
  
  5-9
  
  10-14
  
  15-19
  
  20-24
  
  25-29
  
  30-34 35 ou +
  Classes d'âges
  
  %
  %
  
  3DN@IG%;S%^%<>AJQIDGE%ALDKDO@G?GKJ%D?HBIJ>KJGE%F>KE%L>%?@ABCDEADFBEG%EGLBK%L/gNG%GK%899Y;;%
  %
  0:%8;M78LG;%LG;%A;8'19()$1B0$8DIGRV;%J89:R9J7=;M;:D%=;F%;:X7:DF%;:%K7F%kY;%OGFLGZB%@T
  32%7:FS%M79F%LG;%FI:%9MJ7RD%FG8%=;F%D87:RV;F%NZkY;F%FGJ<89;G8;F%N9M9:G;"%c@Sbo%N;F%J;D9DF%
  ;:X7:DF%FI:D%RI=I:9F<F%J78%*;80)%$)"%F;:F9K=;%B%=7%M<DV9R9==9:;"%&Z7J8\F%=;%$#(S%=7%JIJG=7D9I:%
  N;%R;F%N;G^%Y;8M;F%;:%122`%<D79D%8;FJ;RD9?;M;:D%N;%`2S`o%;D%`>S>o"%6;F%J9RF%N;%X8<LG;:R;%
  N;%R;F%N;G^%Y;8M;F%FI:D%9FI=<F%RV;g%=;F%;:X7:DFS%7=I8F%LGZI:%IKF;8?;%G:;%N9M9:GD9I:%N;%=7%
  RI=I:9F7D9I:%K7RD<89;::;%J78%R;G^TR9%RV;g%=;F%7NG=D;F"%2;80$%)&'1-"0%J8<F;:D%RV;g%3AS`o%N;F%
  J7D9;:DF%kY<F%N;%2%B%c%7:FS%7DD;9:D%FI:%J9R%N;%X8<LG;:R;%RV;g%=;F%M7=7N;F%;:D8;%1`%;D%1@%7:F%P%
  >3SAo"%':X9:%I:%J;GD%:ID;8%LG;%=7%J8IJI8D9I:%N;%*;80)%$)"%8<F9FD7:D%B%=7%M<DV9R9==9:;%J8<F;:D%
  RV;g% aSao% N;F% ;:X7:DF% N;% 2% B% c% 7:F% 7DD;9:D% 31S@o% RV;g% =;F% 3`T3@% 7:FS% JG9F% N9M9:G;%
  =<Y\8;M;:D%J78%=7%FG9D;"%%
  %
  ':% IGD8;S% =;% $#(% 7% M9F% ;:% <?9N;:R;% =Z<?I=GD9I:% N;% =7% RI=I:9F7D9I:% K7RD<89;::;% ;:D8;%
  3@@@%;D%122@%;:%RIMJ787:D%=7%J8<F;:R;%N;F%Y;8M;F%B%R;F%N;G^%<JILG;F"%%
  %
  
  %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
  33
  
  %l9=7:%N;F%NI::<;F%122@S%$;Y9FD8;%#87:_79F%N;%=7%(GRI?9FR9NIF;%%
  VDDJPddppp"?79:R8;=7MGRI"I8Yd;qGJ=I7NdJNXd87JJI8Dq8;Y9FD8;q122@"JNX%
  
  %
  %
  
  `a%
  
  INED
  13511
  
  Germes
  Pneumocoque
  
  6,4
  4,2
  
  Streptocoque
  
  6,8
  
  15,0
  36,5
  
  H. influenzae
  
  26,0
  57,6
  
  S. aureus méti S
  
  52,9
  9,2
  8,5
  
  S. aureus méti R
  
  49,1
  
  P. aeruginosa
  
  44,8
  4,7
  
  S. maltophilia
  
  8,4
  
  B. cepacia
  
  3,2
  2,1
  
  A. xylosoxidans
  
  3,1
  4,6
  
  0,0
  M.  tuberculosis 0,0 Mycobactérie atypique 0,5 2,5 1999 2008 13,7 Aspergillus 20,8 0 10 20 30 40 50 60 70 Pourcentage % 3DN@IG%;R%^%&BH@L>JDBK%FG%P>AJQIDGE%DEBLQGE%GK%899Y%AB?H>IQG%c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`o% N;F% J7D9;:DF% ;:% JV7F;% D;8M9:7=;% FI:D% %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% 31 %l9=7:%N;F%NI::<;F%122@S%$;Y9FD8;%#87:_79F%N;%=7%(GRI?9FR9NIF;%% VDDJPddppp"?79:R8;=7MGRI"I8Yd;qGJ=I7NdJNXd87JJI8Dq8;Y9FD8;q122@"JNX% % % `c% RI:D7M9:<F%J78%2;0$%)&'1-"0%e(G:Rm%$38/-((S%122af"%0:%:ID;87%R;J;:N7:DS%RIMM;%=;%MI:D8;% =;%Y87JV9LG;%J8<R<N;:DS%LG;%=7%J8<?7=;:R;%N;F%9:X;RD9I:F%B%2;80$%)&'1-"0%F;MK=;%N9M9:G;8%7G% RIG8F%N;F%7::<;F"%% % );DD;% K7RD<89;% F;% N<?;=IJJ;% FIGF% XI8M;% N;% M9R8IRI=I:9;F% ;:DIG8<;F% NZ;^IJI=EF7RRV789N;FS% <Y7=;M;:D% 7JJ;=<F% 7=Y9:7D;FS% R;% LG9% XI8M;% G:;% M7D89R;% G:9FF7:D% =;F% K7RD<89;F%;:D8;%;==;F%;D%7G^%7GD8;F%FD8GRDG8;F"%);8D79:;F%FIGRV;F%J8ING9F;:D%7FF;g%NZ7=Y9:7D;F% JIG8% ]D8;% N9D;F% t%MGRIQN;F%u% e(7897:9TrG8mNO97:% $38 /-((S% 122af"% 67% J89MIT9:X;RD9I:% F;% X79D% J89:R9J7=;M;:D%J78%?I9;%7<89;::;%B%J78D98%N;%=Z;:?98I::;M;:D%N;F%J7D9;:DFS%J78D9RG=9\8;M;:D% =;F% FG8X7R;F% VGM9N;F"% );% FI:D% N;F% FIGRV;F% :I:% MGRIQN;F% Y<:<87=;M;:D% F;:F9K=;F% 7G^% 7:D9K9ID9LG;F"% -;:N7:D% R;DD;% J<89IN;S% 9=% ;FD% ;:RI8;% JIFF9K=;% N;% J78?;:98% B% G:;% <87N9R7D9I:% J=GF%IG%MI9:F%D87:F9DI98;S%F;%RIMJD7:D%;:%MI9F%IG%;:%7::<;F"%6;%D879D;M;:D%9:D;:F9X%J8<RIR;% J78%=;F%7:D9K9ID9LG;F%F;MK=;%8;D78N;8%=7%FG8?;:G;%NZG:;%9:X;RD9I:%RV8I:9LG;%e(G:Rm%$38/-((S% 122af"%% % 6Z;^9FD;:R;% N;% D8I9F% ;^7M;:F% REDIK7RD<89I=IY9LG;F% N;F% R87RV7DF% FGRR;FF9XF% B% G:% MI9F% NZ9:D;8?7==;%9FI=7:D%2;80$%)&'1-"0%%N<X9:9D%=;%J7FF7Y;%B%=7%RV8I:9R9D<"%);%FI:D%7=I8F%N;F%FIGRV;F% MGRIQN;F%LG9%RI=I:9F;:D%=;F%?I9;F%7<89;::;F%e(G:Rm%$38/-((S%122af"%6;G8%9:R9N;:R;%7GYM;:D;% 7?;R%=ZkY;%;D%=Z<?I=GD9?9D<%N;%=7%M7=7N9;%e(7897:9TrG8mNO97:%$38/-((S%122af"%'==;F%FI:D%7FFIR9<;F% B%G:;%N<Y87N7D9I:%N;%=Z<D7D%R=9:9LG;%;D%N;%=7%XI:RD9I:%JG=MI:798;S%79:F9%LGZB%G:%89FLG;%J=GF% 9MJI8D7:D%N;%MI8D7=9D<"%6Z9:X;RD9I:%J78%=;F%FIGRV;F%MGRIQN;F%;FD%<Y7=;M;:D%7FFIR9<;%B%G:;% 7GYM;:D7D9I:%N;%=7%8<JI:F;%9MMG:9D798;%RV;g%=ZVhD;%e-;N;8F;:%$38/-((S%3@@1f"%% % 67% J8INGRD9I:% NZ7=Y9:7D;% J;GD% 7=I8F% 7DD;9:N8;% D8I9F% XI9F% =7% D79==;% N;% =7% K7RD<89;S% RI:D89KG7:D%79:F9%B%=7%?9FRIF9D<%N;F%F<R8<D9I:F%K8I:RV9LG;F"%&;%J=GFS%=Z7=Y9:7D;%7%G:%;XX;D%7:D9T JV7YIRED798;%FG8%=;F%JI=E:GR=<798;F%:;GD8IJV9=;F%e(7897:9TrG8mNO97:%$38/-((S%122af%;D%8<7=9F;% G:% ?<89D7K=;% <R87:% B% =7% 8<JI:F;% 9MMG:9D798;% ;D% B% =7% J<:<D87D9I:% N;F% 7:D9K9ID9LG;F% e)8GEJ;::9:RmS%1232f"%67%J8<F;:R;%NZ7:D9RI8JF%7:D9TJEIRE7:9LG;F%N7:F%=;%F;8GM%7GDV;:D9X9;% =;% FD7N;% NZ9:X;RD9I:% RV8I:9LG;% LG9% F;% D87NG9D% J78% G:;% N9=7D7D9I:% N;F% K8I:RV;F% 7KIGD9FF7:D% J8IY8;FF9?;M;:D%B%=Z9:FGXX9F7:R;%8;FJ987DI98;%e6;:I98%$38/-((S%122>f"%6;F%RG8;F%NZ7:D9K9ID9LG;F% FI:D%7=I8F%8<RG88;:D;F%P%D8I9F%B%LG7D8;%XI9F%J78%7:"%% % % ``% -;N;8F;:% $38 /-((% I:D% M;:<% G:;% <DGN;% ;:% 3@@1% 7X9:% N;% RIMJ78;8% =;F% FIGRV;F% :I:% MGRIQN;F% ;D% =;F% FIGRV;F% MGRIQN;F"% *=F% FGYY\8;:D% LG;% =;F% 7:D9RI8JF% N989Y<F% RI:D8;% 2;8 0$%)&'1-"0%RI:D89KG;:D%B%=7%N<Y87N7D9I:%N;%=7%XI:RD9I:%JG=MI:798;"%67%8<JI:F;%9MMG:9D798;% R7GF;879D% G:;% 9:X=7MM7D9I:% LG9% F;879D% B% =ZI89Y9:;%NG% NIMM7Y;% N;F% D9FFGF"% )V;g% =;F% J7D9;:DF% 7DD;9:DF%J78%=;F%FIGRV;F%MGRIQN;FS%=7%8<JI:F;%9MMG:9D798;%<D79D%J=GF%9MJI8D7:D;S%=;%C'(H%;D% =Z<D7D%:GD89D9I:;=%J=GF%N9M9:G<F%LG;%RV;g%=;F%J7D9;:DF%9:X;RD<F%J78%=;F%FIGRV;F%:I:%MGRIQN;F"% );DD;%9:D;:F;%8<JI:F;%9MMG:9D798;%J8I?ILG<;%J78%=Z9:X;RD9I:%MGRIQN;%JIG8879D%]D8;%NG;%B%=7% Y87:N;% LG7:D9D<% NZ7=Y9:7D;F% F<R8<D<;% J78% R;F% Y;8M;F"% &;% J=GFS% DIGF% =;F% J7D9;:DF% N<R<N<F% <D79;:D%RI:D7M9:<F%J78%2;80$%)&'1-"0%MGRIQN;%e-;N;8F;:%$38/-((S%3@@1f"%%% % (7=V;G8;GF;M;:D% =7% K7RD<89;% N<?;=IJJ;% G:;% 8<F9FD7:R;S% ;D% 7?;R% =;% D;MJFS% 8<7JJ787nD% 9:<=GRD7K=;M;:D%N7:F%=;F%F<R8<D9I:F%K8I:RV9LG;F%e(G:Rm%$38/-((S%122af"%':%;XX;DS%Y8kR;%B%=7% X79K=;% J;8M<7K9=9D<% N;% F7% M;MK87:;% ;^D;8:;S% B% =7% J8INGRD9I:% N;% K]D7T=7RD7M7F;% ;D% B% F7% R7J7R9D<% N;% MGD7D9I:S% R;% Y;8M;% J;GD% N;?;:98% MG=D98<F9FD7:D% e6;:I98% $38 /-((S% 122>f"% 6Z<87N9R7D9I:%N;%=Z9:X;RD9I:%JG=MI:798;%7J8\F%R;%FD7N;%;FD%Y<:<87=;M;:D%9MJIFF9K=;%e69JGM7S% 1232f"%%% 8=8=8=8 J"'1?M&%.%..7(%'72!7(% /?;R%2;80$%)&'1-"0S%*;80)%$)"%;FD%=7%K7RD<89;%=7%J=GF%8<J7:NG;%RV;g%=;F%J7D9;:DF%7DD;9:DF% N;%MGRI?9FR9NIF;"%);F%N;8:9\8;F%7::<;FS%=7%J8<?7=;:R;%N;F%*;80)%$)"8.C3'L?%7%7GYM;:D<"%':% 1223S%NZ7J8\F%=;%)EFD9R%#9K8IF9F%#IG:N7D9I:%-7D9;:D%$;Y9FD8E%7G^%'D7DFT!:9FS%>Sao%N;F%J7D9;:DF% 7?79;:D% N;F% FIGRV;F% *;8 0)%$)"8 .C3'L?"% ':% 122AS% =;% :IMK8;% N;% J7D9;:DF% JI8D;G8F% N;% R;F% FIGRV;F% FZ;FD% <=;?<% B% 11Sbo"% );DD;% J8<?7=;:R;% DIGRV;% DIGF% =;F% kY;FS% J78D9RG=9\8;M;:D% =;F% 7NI=;FR;:DF%N;%33%B%3>%7:F%e69JGM7S%1232f"%% % );DD;% K7RD<89;% RI=I:9F;% X8<LG;MM;:D% =Z9:D<89;G8% N;F% :789:;F"% ':?98I:% a>o% N;F% ;:X7:DF% N;%3%B%3@%7:F%FI:D%RI:R;8:<F"%'==;%;FD%FIG?;:D%F7:F%RI:F<LG;:R;F%JIG8%=ZVhD;S%M79F%RI:FD9DG;% G:% 8<F;8?I98% 9MJI8D7:D% JIG8% % =Z7RLG9F9D9I:% J78% =;F% 7GD8;F% J;8FI::;F% e69JGM7S% 1232f"% ':% 8;?7:RV;S% 9=% J;GD% 7?I98% N;F% RI:F<LG;:R;F% RV;g% =;F% J7D9;:DF% FGK9FF7:D% G:;% =IG8N;% J89F;% ;:% RV78Y;% ;D% RV;g% =;F% 9MMG:IN<J89M<F% e69JGM7S% 1232f"% *=% 7NV\8;% B% =Z<J9DV<=9GM% 8;FJ987DI98;% % % `b% Y8kR;% B% R;8D79:F% RI:FD9DG7:DF% N;% F7% J78I9% e7R9N;% D;9RVIQLG;f% ;D% <RV7JJ;% 7G^% N<X;:F;F% N;% =ZI8Y7:9FM;% e(7897:9TrG8mNO97:% $38 /-((S% 122af"% *=% J78D9R9J;% B% =7% N<Y87N7D9I:% JG=MI:798;% ;D% X7?I89F;% =Z7NV<F9I:% N;% 2;8 0$%)&'1-"0% ;:% N<M7FLG7:D% N;F% 8<R;JD;G8F% <J9DV<=97G^% e(G:Rm% $38 /-((S% 122af"% 0:% IKF;8?;% FIG?;:D% N;% R;% X79D% G:;% RI=I:9F7D9I:% B% 2;8 0$%)&'1-"0% JIFD<89;G8;% B% R;==;%J78%*;80)%$)""%);J;:N7:DS%K;7GRIGJ%N;%J7D9;:DF%FI:D%RI=I:9F<F%J78%=;F%N;G^%;:%M]M;% D;MJF%e(7897:9TrG8mNO97:%$38/-((S%122af"% % 0:% N9FFIR9;% =;F% FIGRV;F% M<D9T$% ;D% =;F% FIGRV;F% M<D9TH"% ':% ;XX;DS% *;8 0)%$)"% M<D9T$% 7% G:% JIG?I98%J7DVIY\:;%J=GF%9MJI8D7:D%LG;%*;80)%$)"%M<D9TH"%);=7%FZ;^J=9LG;879D%J78%=7%J8INGRD9I:% FJ<R9X9LG;% N;% DI^9:;F% ;D% N;% X7RD;G8F% N;% ?98G=;:R;% J78% =7% FIGRV;% M<D9T$S% LG9% 7G879D% JIG8% RI:F<LG;:R;%G:;%7GYM;:D7D9I:%N;%=Z9:X=7MM7D9I:%N;F%?I9;F%8;FJ987DI98;F%e$;:%$38/-((S%122>f"% &7:F% G:;% <DGN;% 7M<89R79:;% ;:% 122>S% =;F% J7D9;:DF% <D7:D% RI=I:9F<F% J78% N;F% FIGRV;F% M<D9T$% 7?79;:D%G:%C'(H%F9Y:9X9R7D9?;M;:D%N9M9:G<%J78%87JJI8D%7G^%J7D9;:DF%7XX;RD<F%J78%=;F%FIGRV;F% M<D9TH%e$;:%$38/-((S%122>f"%%% % % 6;F% FIGRV;F% N;% *;8 0)%$)"% FI:D% V7K9DG;==;M;:D% F;:F9K=;F% B% N;% :IMK8;G^% 7:D9K9ID9LG;F% RIMM;% =;F% R<JV7=IFJI89:;FS% RID89MI^7gI=;S% 7R9N;% XGF9N9LG;w% e6;:I98% $38 /-((S% 122>f"% );J;:N7:DS% =7% J8<F;:R;% N;% *;8 0)%$)"8 M<D9T$% ;FD% 7FFIR9<;% B% G:% GF7Y;% J=GF% 9MJI8D7:D% N;F% 7:D9K9ID9LG;F%e$;:%$38/-((S%122>f"%&7:F%=;F%XI8M;F%F<?\8;F%;D%JIG8%=;F%FIGRV;F%8<F9FD7:D;F%B%=7% M<DV9R9==9:;S% I:% GD9=9F;% N;F% K9DV<87J9;F% I87=;F% eD89M;DVIJ89M;TM7R8I=9N;FS% XGR9N9:;T 89X7MJ9R9:;% J78% ;^;MJ=;f% IG% J78% ?I9;% J78;:DV<87=;"% 6;% D879D;M;:D% J8IJVE=7RD9LG;% 7?7:D% =7% RI=I:9F7D9I:% B% *;8 0)%$)"% :;% F;MK=;% J7F% 7JJI8D;8% N;% K<:<X9R;% R=9:9LG;% ;D% X7?I89F;879D% =Z9:NGRD9I:%N;%8<F9FD7:R;F%;D%=7%RI=I:9F7D9I:%J78%2;80$%)&'1-"0%e6;:I98%$38/-((S%122>f"%% 8=8=8=S J"!-%"2%1?%:%-'(%:'&"%1?/&/'% *;8.0(3-#4'('0%X79F79D%9:9D97==;M;:D%J78D9;%NG%Y;:8;%2"$),-.-10""%-G9F%9=%7%<D<%R=7FF<%N7:F% =;% Y;:8;% M0134-.-10"S% ;D% ;:% 3@@a% N7:F% R;=G9% N;F% *3$1-3%-#4-.-10"% e69JGM7S% 1232f"% );% N;8:9;8% Y;:8;% ;FD% RI:FD9DG<% N;% LG7D8;% ;FJ\R;F% M79F% F;G=;% *;8 .0(3-#4'('0% ;FD% RI::G;% JIG8% ;:Y;:N8;8% N;F% 9:X;RD9I:F% RV;g% =;F% VGM79:F"% '==;% ;FD% RI:F9N<8<;% RIMM;% <M;8Y;:D% IJJI8DG:9FD;%N7:F%=7%MGRI?9FR9NIF;"%':%;XX;DS%N7:F%=;%R7N8;%N;%R;DD;%J7DVI=IY9;S%;==;%7%<D<% % % `>% 9FI=<;%7?;R%G:;%X8<LG;:R;%R8I9FF7:D;%N7:F%=;F%?I9;F%8;FJ987DI98;F%N;F%J7D9;:DF%R;F%N;8:9\8;F% 7::<;F"% 6;F% J7D9;:DF% J=GF% kY<F% F;879;:D% NZ7?7:D7Y;% RI=I:9F<F% J78% R;DD;% K7RD<89;% LG;% =;F% J7D9;:DF%O;G:;F%e6;:I98%$38/-((S%122>f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e6II:;E%$38/-((S%122@f"%6;F%RI8D9RIQN;F%J78%?I9;%I87=;S%=ZGD9=9F7D9I:%N;%J=GF9;G8F%7:D9K9ID9LG;F% ;D%=|9FI=7D9I:%NZ!;89).'&03)"8FI:D%7FFIR9<F%B%=Z9FI=7D9I:%N;%*;8.0(3-#4'('0%e69JGM7S%1232f"% *;8.0(3-#4'('0%;FD%R7J7K=;%N;%XI8M;8%G:%K9IX9=M%7GDIG8%NZ;==;%M]M;%IG%7?;R%NZ7GD8;F%;FJ\R;F% J7DVIY\:;FS% R;% LG9% 7GYM;:D;% F7% 8<F9FD7:R;% ?9F% B% ?9F% N;F% JV7YIRED;F% ;D% N;F% 7:D9K9ID9LG;F% e6II:;E%$38/-((S%122@f"%% % 'D7:D% NI::<% F7% Y87:N;% 8<F9FD7:R;% X7R;% 7G^% 7:D9K9ID9LG;FS% 9=% ;FD% N9XX9R9=;% N;% D879D;8% R;% Y;8M;"% 6;% RID89MI^7gI=;S% F;G=% IG% ;:% 7FFIR97D9I:S% 8;FD;% =;% D879D;M;:D% N;% RVI9^"% ':% F;RI:N;% 9:D;:D9I:S%9=%;FD%JIFF9K=;%NZGD9=9F;8%=Z7FFIR97D9I:%7R9N;%R=7?G=7:9LG;TD9R78R9==9:;%e6II:;E%$38/-((S% 122@f"% ':% 8;?7:RV;S% =7% K7D<89;% ;FD% 8<F9FD7:D;% ?9F% B% ?9F% N;F% J<:9R9==9:;FS% R<JV7=IFJI89:;FS% R78K7J<:\M;FS%LG9:I=I:;FS%7M9:IY=ERIF9N;FS%D<D87RER=9:;%e6II:;E%$38/-((S%122@f%;D%8<F9FD;%B% N;F%XI8D;F%RI:R;:D87D9I:F%N;%DIK87MER9:;%e6;:I98%;D%)I==S%122>f"% 8=8=8=R *G%AB?HLGbG%N72O?%&0!2/'#.!1'./'% 6;8 +$#0+'0% X79D% <Y7=;M;:D% J78D9;% N;F% J7DVIY\:;F% <M;8Y;:DF% N;% =7% MGRI?9FR9NIF;"% 67% F<?<89D<%N;F%9:X;RD9I:F%J8I?ILG<;%J78%R;%Y;8M;%;FD%?7897K=;%F;=I:%=;F%J7D9;:DF%;D%=;F%FIGRV;FS% 7==7:D% NG% JI8D7Y;% RV8I:9LG;% B% =Z9:X;RD9I:% Y87?;% <?I=G7:D% OGFLGZ7G% N<R\F% ;:% LG;=LG;F% F;M79:;F% IG% MI9F% e(7897:9TrG8mNO97:% $38 /-((S% 122af"% 6Z9:R9N;:R;% 7RDG;==;M;:D% F;MK=;% 9:X<89;G8;%B%1S`o%N;%=7%JIJG=7D9I:%N;F%J7D9;:DF%;:%#87:R;%e6;:I98%$38/-((S%122>f"%% % % `A% 0:% N9FD9:YG;% N7:F% =;% RIMJ=;^;% 6;8 +$#0+'0% :;GX% Y<:IMI?78F% ;D% 3>% ;FJ\R;F"% );% D;8M;% N<F9Y:;% N;F% FIGRV;F% JV<:IDEJ9LG;M;:D% F9M9=798;F% M79F% Y<:<D9LG;M;:D% V<D<8IY\:;F"% )Z;FD% G:;% :ID9I:% 9MJI8D7:D;% R78% 9=% J;8M;D% N;% N9XX<8;:R9;8% =;% JID;:D9;=% J7DVIY\:;% N;% RV7LG;% Y;:IMI?78% e(7897:9TrG8mNO97:% $38 /-((S% 122af"% -78% ;^;MJ=;% G:;% RI=I:9F7D9I:% J78% =;% Y<:IMI?78% ***% ;FD% 7FFIR9<;% B% G:;% N<D<89I87D9I:% 87J9N;% N;% =7% XI:RD9I:% JG=MI:798;% e(7897:9T rG8mNO97:%$38/-((S%122af"% 8 6;8&(0,'-('%7%<D<%M9F%;:%<?9N;:R;%N7:F%G:;%9MJI8D7:D;%J8IJI8D9I:%NZ9:X;RD9I:F%7G%F;9:%N;% =7%MGRI?9FR9NIF;"%);DD;%;FJ\R;%:Z7JJ78D9;:D%J7F%7G%RIMJ=;^;%6;8+$#0+'0"% 6;8 .)(3'F-%01"% ;D% 6;8 +$1-+$#0+'08 FI:D% <Y7=;M;:D% =78Y;M;:D% 9MJ=9LG<F% N7:F% =;F% 9:X;RD9I:F%JG9FLGZ9=F%8;J8<F;:D;:D%J8;FLG;%>2o%NZ;:D8;%;==;F%e69JGM7S%1232f"% % % Species B. cepacia
  B. multivorans
  B. cenocepacia
  B. stabilis
  B. vietnamiensis
  B. dolosa
  B. ambifaria
  B. anthina
  B. pyrrocinia
  B. ubonensis
  B. latens
  B. diffusa
  B. arboris
  B. seminalis
  B. metallica
  B. contaminans
  B. 