None
569 Chemical agents, effect of, on bac- teria, 78 composition of bacteria, 77 products of bacteria, 100 substances, influence of, on growth of bacteria, 89 Chemotaxis, negative, 89 positive, 89 Chester's classification of bacteria, 120 Chicken sarcoma, 546 Chitin, 77 Chlamydozoa, 635 Cholangitis, 276 Cholecystitis, 276 Cholera, Asiatic, 427 carriers^ 431 epidemiology of, 434 serum for prevention of, 438 vaccination against, 437 fowl, bacteria of, 320 hog, 546 bacillus of, 282 spirillum, 427 Chromatin, 69 Chromic-acid cleaning mixture, 25 Churchman on behavior of bacteria to gentian-violet, 59 Cladothrix, 460 asteroides, 460 Classification of bacteria> 116 Chester's, 120 Jensen's, 117 Migula's, 119 physiologic, 117 Claviceps purpurea, 482 Clostridium, 73, 347, 599 pastorianum, 572 Coccacca*, 120 Cocci, Buchanan's nomenclature of, 121 Coccidioidal granuloma, 477 Coccidium cuniculi, 527 656 INDEX Coccoid bodies of actinomycoses, 463, 464 Coccus, 65 golden pus, 76 Coconut-bud rot, 629 Cohendy, 110 Cold, exposure to, predisposing to infection, 129 Colds, 636 Coley's mixture in malignant tumors, 193 Coli, bacillus, 272 CoUoids, 113 Colon test, 612 Colon-typhoid bacilli group, 271 characteristics, 271 subdivisions, 271 Colonies of bacteria, 75 Comma bacillus, 427 Complement, 167 deviation of, 169 fixation of, 169 Complementophile, 167 Composition of bacteria, 63 ConjunctivitLs, 334, 635 Copper sulphate, 95 Corrosive sublimate, 94 Cowpox and small-pox, relation be- tween, 532 Crenothrix, 104 Crithidia, 502 Crotin, 115 Crown-gall of plants, 632 Culex, 495, 511, 514, 519 and anopheles, differences between, 514 Cultivation of anaerobic bacteria, 41 Culture-media agar, 32 beef-broth, 29 blood-serum, 32 dextrose, 32 dextrose-free broth, 31 gelatin, 31 Heinemann's, 33 invention of, 21 lactose litmus agar, 32 Utmus milk, 32 Loffler's blood-serum mixture, 33 milk, 32 non-protein, 34 potato, 33 preparation of, 28 special, 34 synthetic, 34 Lschinsky's, Frankel's modification, 34 Cultures, plate, technic of making, 47 pure, cultural characteristics, 61 methods of obtaining, 46 morphologic appearance, 60 study of, 60 Curing of tobacco, 590 Cutaneous plague, 327 reaction, 307, 457 Cystitis, 277, 296 Cytolytic serum, 154 Cytophile, 167 Cytoplasm, 69 DA^^r8z virus, 285 Death-point, thermal, of bacteria, 37 80 Degeneration forms of bacteria, 65 Delhi boU, 503 Deneke's spirillum, 442 Den^e fever, 546, 636 Demtrification by bacteria, 586 true, 586 Dermatitis, blastomycetic, 475 Dermatomycoses caused by fungu:^, 483 Deuterotoxins, 113 Development of bacteria, 63 Deviation of complement, 169 Devouring cells, 156 Dextrose and lactose htmus agar, 32 Dextrose-free broth, preparation of, 31 Diarrhea, infantile, milk as cause, 557 Dilutions of polluted fluids, 48 Dimensions of bacteria, 63 Diphtheria, 247 antitoxin, 257 concentration, 259 Banzhaf's method, 261 Gibson's method, 259 curative value, 261 preparation of, 136, 259 results of treatment with, 263 avian, 265 bacillus, 247. death-rate from, 263 diagnosis of, method, 269 fowl, 546 mixed infections, 266 modes of infection, 263 Neisser's method for, 59 prophylaxis of, 265 pseudodiphtheria bacilli, 267 Schick reaction in, 270 streptococcus in, 195 toxin, 255 Diplobacillus, Morax-Axenfeld, 424 Diplococcus in mumps, 638 pneumoniae, 206. See also Pneumo- coccus. rheumaticus, 198 Disease, 126 bacterial, of alfalfa, 626 germ theor>' of, 128 Hippocratic theory, 127 in €uiimal organisms, 26 INDEX 657 Disease, theories of, 126 Disinfectants, 39, 91 influence of, on growth of bacteria, 91 testing, 39 standardizing, 39 Disinfection, procedures for, 96 Disintegration products of bacteria, 100 Distribution of bacteria, 133 Dorset's method of isolating tubercle bacillus, 375 Dourine, 498 Drepanidium, 520 Drigalski-Conradi method of isolating t3rphoid bacillus, 291 Drugs, resistance of trypanosomes to, 501 Drusen, 461, 468 Dum-dum fever, 601 Durham's peptone solution, 35 Dust, typhoid bacilli in, 305 Dysentery, 313 ameba of, 487. See also AmdM of dysentery. bacillus, 313 characteristics, 313 pathogenesis, 316 toxins of, 317 varieties, 314 serum-therapy, 317 East Coast fever, 523 Fklema, malignant, 350 Egg plant, brown rot of, 623 Ehrlich's receptor theory of im- munity, 164 Electricity, influence of, on growth of bacteria, 88 Eltor vibrios, 440 Emetin, 492 Endocarditis, acute, 231 ulcerative, streptococcus as cause, 195 Endo's method of isolating t3rphoid bacillus, 292. Endospores, 73 Endotoxins, 114 of tubercle bacillus, 377 specific, 114 Entameba coli, 490 gingivalis, 492 histolytica, 487, 491 tetragena, 492 Enteric fever, 296 Enteritidis bacillus, 281 Enteritis, streptococcus as cause, 196 Entoplasm of bacteria, 68 Environment, influence of, on growth of bacteria, 87 Enzymes produced by bacteria, 102 42 Enzymes produced by yeasts, 473 Epidemic cerebrospinal meningitis, 218 infantile paralysis, 541 mode of transmission, 543 Epithelioma contagiosum, 546 Epstein's stain, 59 Ergotism, 482 Erysipelais and puerperal fever, rela- tion, 194 effect of, on malignant tumors, 193 streptococcus of, 193 Estivo-autumnal fever, parasites of, 507 tertian form, 510 Eumycetes, 479 Excretions, production of, by bacteria, 100 Extracellular toxins, 114 Facultative ana&*obes, 83 Farcies du boeuf, 460 Farcy, 411 buds, 411 pipes, 411 Fatigue predisposing to infection, 129 Favus, 483 Feces, sterilization of, 96 typhoid bacilh in, 297 Fermentation, 20 acetic acid, 595 alcoholic, yeasts producing, 479 bakery, 596 of milk, 547 alcoholic, 549 butyric acid, 549 lactic, 547 of sauerkraut, 596 production of, by bacteria, 102 tube, 35 Film preparation, 53 Filterable viruses, 528 diseases due to, 531 modes of transmission, 530 Filter-plants, 616, 617 Filters, 46 Berkcfeld, 619 mechanical, 619 Pasteur-Chamber land, 619 pressure, 47 Filtration of water, 616 rapid, of toxins, apparatus for, 46 sterilization by, 46 Finkler and Prior, spirillum of, 442 Fishing, 47 Fission-fungi, 116 Fixation of complement, 169 FlageUa, 61, 72 staining of, 56 Loffler's method, 57 Van Ermengem's method, 57. 658 INDEX Flax, retting of, 5d9 Fleas in transmission of trypanoeomes, 495, 496 Flexner-Jobling serum, 222 Flies as carriers of virus of infantile paralysis, 544 as cause of typhoid fever, 304 Fluctuating type of bacteria, 122 Food assimilation, relation of bacteria to, by higher forms of life, 109 bacteria in, 592 preservation of, 592 substances as cause of t3rphoid fever, 304 Food-poisoning, 423 Food-supply of bacteria, 85 Foot-and-mouth disease, 541 milk as cause, 556 Forceps, cover-glass, Stewart's, 53 Formaldehyd, ^ Formalin, 92 Fowl cholera, bacteria of, 320, 441 diphtheria, 546 p^, 546 tuberculosis. 375 Frankel's modification of Uschinsky's culture-media, 34 pneumococcus, 206 Free receptors, 165 Freezing, effect of, on bacteria in water, 616 Friedlander's pneumobacillus, 279 Frost's gasometer card, 36 Fungus, budding, 472 fi^on-, 120 of f avus, 484 of pityriasis, 484 of ringworm, 484 of tinea versicolor, 484 skin diseases from, 484 thrush, 483 Gaij>6ickness, 498 Gakiekte, 498 Gambian horse disease, 498 Gametophores, 479 Gangrene, 352 Gangrenous stomatitis, 361 Garget, infection of milk from, 556 Gartner's bacillus, 281 Gas bacillus, 352 formula of bacteria, 37 Gas-production, method of measuring, 36 Gasometer card, Frost's, 36 Gelatin, preparation of, 31 Gentian-viofet, carbolic, 54 selective bactericidal action of, 59 Germ carriers, typhoid, 306 Germicidal power of blood, 151 Gkon-Sachs' bacillus, 350 Gibbon's method of concentration of diphtheria antitoxin, 259 Gins' modification of Neisser's granule stain, 59 Glanders, 408 bacillus of, 408. See also BaciUus mallei. diagnosis of, 413 i^g^utination method, 414 gumea-pig inoculation, 413 mallein test, 413 immunity to, 415 Glassware, stenlixation of, 24 Glossina morsitans, 497, 501 palpahs as cause of sleeping sick- ness, 499 Golden pus coccus, 76 Gonococcus, 224 cultural characteristics, 224 inoculation experiments, 227 morpholo^c characteristics, 224 results of mfection with, 22S vaccine, 229 Wertheim's method of cultivating, 226 Gonorrhea, 224 micrococcus of, 224. See also Gonococcus. Gonorrheal arthritis, vaccine treat- ment, 229 ophthalmia, 228 vulvovaginitis, 229 Gram-negative bacteria, 54 Gram-positive bacteria, 54 Gram's method of staining, 54 Granules, metachromatic, 69 polar, 69 Granulobacter pectinovorum, 599 Granuloma, coccidioidal, 477 Granville wilt of tobacco plant, 624 Grass bacillas, 398 Group a^utination, 174 agglutinins, 174 Growth of bacteria, 71 influence of antiseptics on, 91 of atmospheric pressure on, 88 of chemical substances on, 89 of disinfectants on, 91 of electricity on, 88 of environment on, 87 of food-supply on, 85 of light on, 81 of mechanical agitation on, 87 of moisture on, 81 of nutrient substance on, 87 of oxygen on, 83 of temperature on, 78 Gruber-Widal reaction in t3rphoid fever, 170, 308 Guinea-pig inoculation in diagnosis of glanders, 413 Gum disease, 634 INDEX 659 Haffkine's prophylactic, 329 Halteridium, 493 Hanging block, 52 drop, 52 Haptophore atom-group, 113 Harris method of isolating typhoid bacillus, 296 Hay bacillus, 245 Heat, expasure to, predisposing to infection, 129 in preservation of foods, 594 production of, by bacteria, 99 resistance of tubercle bacillus to, 377 separation of bacterial species by, 48 Heinemann's culture-medium, 33 Heine-Medin disease, 541 Hemagglutinins, 115, 173 Hemic3lulo8e, 69 Hemolysin, 115 from streptococcus, 192 Hemolysins, formation of, in liver, 150 Hemolytic serum, 154, 454 Hemoproteus, 493, 519 Hemorrhagic septicemia, 319 bacteria of, 319 Hemorrha^n, 115 Hemospondia, 519 Hemp, retting of, 599 Hepatotoxic serum, 154 Heredity, influence of, upon tubercu- losis, 391 Herpes tonsiu*ans, 4S4 Herpetomonas, 501 Hesse's method of isolating tubercle bacillus, 375 Hippobosca rufipes, 498 Hippocratic theory of disease, 127 Hiss' inulin-serum-water test for de- termining pneumococcus, 218 Hodgkin's disease. intestinal, 332 Influenza-like bacilli in whooping- cough, 335 Infusoria, 487 Inoculation, animal, 51 separation of bacterial species by, 48 as avenue of infection for tubercle bacillus, 383 Instruments, sterilization of, 24 Intermediary body, 166 Intestinal amebse, process of repro- duction, 491 varieties, 490 anthrax, 242 influenza, 332 streptococci, 196 Intestmes, infection throujgh, 136 Intra-uterine infection with tubercu- losis, 392 Inulin-serum-water test for determin- ing pneumococcus, 208 Invertase, 473 Involution forms of bacteria, 65 Iron bacteria, 104 Jaundice, infectious, 423 malignant, 523 Jaw, lumpy, 467 Jensen's classification of bacteria, 117 physiologic classification of bac- teria, 117 Kala-azar, 501 Katalase, 591 Kedrowski's stain, 400 Kefir 549 Klebs-Loffler bacillus. 247. See also Bacillus diphtheria. Koch's apparatus for coagulating and sterilizing blood-serum, 28 Koch-Weeks bacillus, 334 Koumiss, 549 Lactic acid bacteria, 547 fermentation of milk, 547 Lactose, 547 bile presumptive-tost, 612 La fievrc typhoide, 296 Tristeza, 520 Lautenschlager's hot-air steriliser, 25 Lecithin, 168 Leech in transmission of trypanoeomes« of fish, reptiles, and amphibia, 493 Le^imiinoBse, 575 Leishman-Donovan bodies, 502 Leishmania, 501 tropica, 503 Leprosy, 399 bacillus of, 399. See also Bacillus lepra. animal experiments in, 402 rat, 403 Leptothrix buccalis, 460 mycoses, 459 ochracea, 104 Leukocidin, 183 Leukocytes in milk, 556, 557 Leukocytosis, 163 Lice in transmission of relapsing fever, 448 Life without microbes, 110 Light, influence of, on growth of bac- teria, 81 production of, by bacteria, 100 Litmus milk as culture-medium, 32 Liver, formation of antibodies in, 150 Localization of streptococci elective, 125 Locomotion, organs of, of bacteria, 69 Loffler's blood-serum mixture, 33 method of isolating typhoid bacillus, 295 methylene-blue stain, 54 serum for isolating diphtheria bacil- lus, 251 Lophotricha, 71 Luetin, 457 Lumpy jaw, 467 Lungs, infection through, 135 MacFadyen's agglutination method in diagnosis of glanders, 414 Macrogametes, 509 Madura foot, 470. See also Mycetoma. Mai de Caderas, 498 du coit, 498 Malaria, 504 bovine, 520 gram prophylaxis, 518 half-gram prophylaxis, 618 mosquito in dissemination of, 490 of cattle, 498 prophylaxis, 517 Malarial organisms, Romanowsky's stain for, 58 parasites, 504 asexual development, 505 estivo-autumnal, 507 quotidian forQi, 508 tertian form, 508 INDEX 661 Malarial parasites, morphology, 506 quartan, 506 quotidian, 509 sexual phase, 510 tertian, 506 Malignant edema, 350 jaundice, 523 pustule, 241 tumors and blastomycetes, relation between, 478 Coley's mixture in, ^193 effect of erysipelas on, 193 Malignes cedem, 350 Mallein test in diagnosis of glanders, 413 Malta fever, 416 Maltase, 473 Mammalian tuberculosis, 380 Marmorek's serum, 204 Mastigophora, 489 Mastitis, 556 Measles, 540 Mechanical agitation, influence of, on growth of bacteria, 87 Media, culture-, preparation of, 28. See also CtUture-'media. Mediterranean fever, 416 Meningitis, cerebrospinal, epidemic, 218 Meningococcus, 218 agglutination of, 222 antiserum for, 2i22 cultural characteristics, 219 immunity to, 222 morphology of, 218 pathogenicity for animals, 222 for man, 220 Menzer's serum, 205 Mercuric chlorid, 94 Mercury, bichlorid of, 94 Mesentericus, bacillus, 245 Metabiosis, 568 Metachromatic granules, 69 Metastasis, 133 Microbe septic^mique du salive, 209 Micrococcus, 65, 120 catarrhalis, 230 gonorrhoea, 224. See also Gono- coccus. intracellularis, 218. See also Menin- ffOCOCCUS. lanceolatus, 206. See also Pneumo- COCCU8. melitensis, 416 agglutination test for, 417 meningitidis, 218. See also Men- ingococcus. pathogenic, 230 tetragenus, 231 Eymogenes, 231 Microgametes, 509, 512 Microgametocyte, 512 Micronucleus, 494 Microscopic examination of bacteria, 51 Microsporon furfur, 484 Migula 8 classification of bacteria, 119 Milchsaure, 547 Milk as culture-medium, 32 bacillus tuberculosis in, 556 typhosus in, 555 bacteria in, 551 effect of pasteurization on, 559 number of, 552 sources of, 551 bacteriologv of, 547 blue, from Dacteria, 547 butyric acid bacillus in, 549 diseases of, from bacteria, 550 fermentation of, 547 alcohohc, 549 butyric acid, 549 lactic, 548 foot-and-mouth disease from, 556 infantile diarrhea from, 557 infection from garget, 556 leukocytes in, 556, 557 litmus, as culture-medium, 32 pasteurization of, 559 pathogenic bacteria in, 555 products, bacteria in, 547, 562 red, from bacteria, 550 sour, bacteria in, 547 streptococcus in, 547, 557, 558 typhoid bacillus in, 303 yellow, from bacteria, 550 MUzbrand, 233 Mixed infection, 133 Moisture, influence of, on growth of bacteria, 81 Moller's spore stain, 56 MoUuscum contagiosum, 546 Monilia Candida, 483 Monotricha, 71 Monstrosities in bacteria, 67 Morax-Axenfeld diplobacillus, 424 Mosaic disease of tobacco, 546 Moser's serum, 2^ Mosquito in dissemination of malaria, 510 in transmission of yellow fever, 537 Mother of vinegar, 594 Motility of bacteria, 69 Mucor, 482 mucedo, 479, 481 Mucosus capsulatus group of bacilli, 280 streptococcus, 208 Mucous membrane, infection through, 134 Mumps, 637 Musgrave and Clegg's method of cul- tivating ameba of dysentery, 488 Mutations, 122 662 INDEX Mycelium, 479 Mycetoma, 470 black variety, 471 white variety, 470 Mycoderma aceti, 595 Mycorrhiza, 579 Mycoses, leptothrix, 460 Nocardia, 460 Mykol, 373 Myxobolus cyprini, 527 Myxosporidia, 527 Naqana, 497 Naples cholera germ, 273 Negri bodies, 534 method of examining for, 534 Neisser's method of staining diph- theria bacilli, 59 Nephrotoxic serum, 154 Neurotoxin, 115 NicoUe's carbolic gentian>violet, 54 Nitrification by bacteria, 580 Nitro-culture, 578 Nitrogen, 578 assimilation of, by bacteria, 573 circle, 571 • compounds, relation of bacteria to, 571 Nitrogen-fixation by bacteria, 571 by nodule bacteria, 574 by soil bacteria, 571 Nitrosomona^, 582 Nocardia mycoses, 460 Nocardiosis, 460 Nodule bacteria, nitrogen-fixation by, 574 Noguchi's method of cultivating spiro- chetes outside body, 444 Noma, 361 Nomenclature of bacteriology, 121 Non-protein culture-media, 34 Nosema bombycis, 527 Novy and MacNeal's method of culti- vating rat trypanosome, 496 Novy's jar, 49 Nucleoproteins from tubercle bacillus, 377 Nutriment, influence of, on growth of bacteria, 87 Nuttallia equi, 526 Obligatory aerobes, 83 anaerobes, 83 Ocular tuberculin reaction, 394 Oed^me malin, 350 Oidiomycosis, 475 Oidium, 473 albicans, 478, 483 lactis, 478, 566 Olive-knot, 630 Ookinete, 512 Ophthalmia, gonorrheal, 228 Opsonic index, 161 method of treatment, 162 technique, 159 Opsonins, 158 Organism, external defenses of, 134 Onental sore, 503 Oroya fever, 520 Osteosarcoma, 461 Oxidase, 591 Oxygen, absorption of, in ana&x)bic cultures, 50 influence of, on growth of bacteria, 83 Ozena bacillus, 280 Panophthalmitis, 245 Pappataci fever, 546 Pappenheim's stain, 55 Paracolon bacillus, 282 Paralysis, epidemic infantile, 541 mode of transmission, 543 Parasites, 86 malarial, 504. protozoan, 486 Parasitic stomatitis, 478 Paratyphoid bacillus, 282 Pasteur-Chamberland filter, 619 Pasteurization of milk, 559 Pasteur's treatment for hydrophobia, 535 Pathogenesis, 128 Pathogenic bacteria, 128 in milk, 555 protozoa, 486 spirilla. 427 staphylococcus, 187 trichomycetes, 459 yeasts, 474 material, examination of, 60 Pathologic material, study of, 60 Pathologist's warts, 387 Pear blight, 621 Pearl-disease of cattle, 381 P6brine, 527 Pectin, 599 Pectosinasc, 599 Pella^a, 399 PcniciUium, 480, 598 Camembert, 566 candidum, 566 crustaceum, 481 glaucum. 566, 603 Peptone solution, Dunham's, 35 Perithecium, 480 Peritricha, 71 Perlsucht, 381 Peroxidase, 591 INDEX 663 Pertussis, 335 Pestis minor, 327 Petuning of tobacco, 591 Pfeiffer's phenomenon, 153 Phagocyte theory, 156 Phagocytes, 156 Phenol, 95 coefficient, hygienic laboratory, 40 Phenomenon, P^iffer's, 153 Phosphorescence, production of, by bacteria, 100 Photogen, 100 Phycomycetes, 479 Physical agents, efifect of, on bacteria, 78 Phytophchorus^ bacillus, 624 Phytophthora mfectans, 482 Phytotoxins, 115 Pigment, production of, by bacteria, 93 Pine oil disinfectant, 96 Piroplasma, 520, 637 bo vis, 521 canis, 523 diver^ens, 523 infection, prevention of, 520 ovis, 526 parvum, 528 Pityriasis, fungus of, 484 Placental infection with tuberculosis, 392 Plague, 320 bubonic, 327 modes of transmission, 324 cattle, 546 cutaneous, 327 Haffkine's prophylactic against, 328 immunitv agamst, 326 modes of transmission, 323 pneumonia^ 327 protective moculation against, 329 serum, 329 swine, bacillus of, 282 bacteria of, 329 Plant tumor, 633 Plants, bacterial diseases of, 621 crown-gall of, 632 wilt disease of, 622 Plasmodium falciparum, 507 immaculatum, 507 malaria?, 506 vivax, 506 Plate cultures, technic of making, 47 Pleuropneumonia of cattle, 546 septic, bacteria of, 320 Pncumobacillus, Friedlander's, 279 Pneumococcus, 206 agglutination of, 214 cultural characteristics, 206 distribution of, 209 Frankel's, 206 Pneumococcus, Hiss' inulin-serum- water test for determining, 208 immunity to, 216 morphologic characteristics, 206 pathogenicity for lower animals, 213 for man, 210 streptococcus group, transmutations in, 209 toxin production, 214 tjrpes of, 209 varieties of, 208 virulence of, 214 Pneumo-enteritis, bacteria of, 319 Pneumonia, plague, 327 serum-therapy in, 216 streptococcus of, 206. See also Pneumococcus. Poisoning, meat, 356 ptomam, 110 Poisons, production of, by bacteria, 110 Polar granules, 69 Pole-bum, 590 Poliomyelitis, acute, 541 mode of transmission, 543 pathogenesis, 545 specific organism of. 542 Potato as culture-media, 33 bacillus, 246, 598 basal stem-rot of, 624 brown rot of, 623 Pox disease of carp, 527 Precipitation test, 176 Precipitinogen, 177 Precipitins, 175 formation of, in liver, 150 Preservation of foods, 592 Pressure filter, 47 Prior and Finkler, spirillum of, 442 Prosodemic diseases, 300 Protein sensitization, 178 Proteins, bacteria, 114 Proteosoma, 519 Proteus vulgaris, 422 Prototoxoida, 110 Protoxins, 110 ProtoBoa, 486, 487 Protozoan parasites, 486 Pseudoactinomycosis, 460 Pseudodiphtheria bacilli, 267 Pseudo-influenza bacillus, 335 Pseudomembranous angina, 360 Pseudopodia, 487 Pseudotuberculosis, 460 Ptomain poisoning, 111 Ptomalns, 110 Puerperal fever and erysipelas, rela- tion, 204 streptococcus as cause, 184, 201, 202 Pulmonar>' anthrax, 241 Pure culture, 21 664 INDEX Pure cultures, 46 cultural characteristics, 61 methods of obtaining, 46 morphologic appearance, 60 study of, 60 Pur6e of baciUi, 321 Purification of water, 616 Puring of leather, 589 Pustule, malignant, 241 Putrefaction, saccharobutyric, 354 Putrefactive products of bacteria, 108 Pyemia, 133 I^ocyanase, 420 Pyocyanin, 420 Pyocyanolysin, 420 Otorrhea alveolaris, 492 I^osalpinx, 352 Quartan malarial parasite, 506 Quarter-evil, 347 Quotidian malarial parasite, 509 RABBrr septicemia, bacteria of, 319 Rabies, 533 Negri bodies in, 534 Pasteur's treatment for, 535 Race XII, 598 Radiobacter, 572 Rat leprosy, 403 Rats as cause of plague, 324 Rauschbrand, 347 Reaction, cutaneous, 307, 394, 457 Receptor theory of Ehrlich of im- munity, 164 Receptors, cell-, 164 free, 165 of first order, 166 of second order, 167, 172 of third order, 168 Red milk from bacteria, 550 Reducing power of bacteria, 35 Reduviidse, 501 Relapsing fever, 442 immunity to, 445 spirochetes of, 442. See also Spirochetes of relapsing fetter. Rennet, 550 Respiratory tract as avenue of infec- tion for tubercle bacillus, 383 Retting of flax, 599 of hemp, 599 Rheumatism, acute articular, strep- tococcus as cause, 197 bacillus in, 355 Rhinitis, 636 Rhinoscleroma, bacillus of, 280 Rhipicephalus bursa, 526 evertri, 526 Rhizobium radicicola, 575 Rhizopus, 598 Rhodesia fever, 523 RhodobacteriaceflB, 106 Rice-water stools, 434 Ricin, 115 Rinderseuche, bacteria of, 319 Rin^orm, 484 Robm, 115 Rocky Mountain spotted fever, 637 Romanowskv's stain, 58 Root tubercles, 575 Rose spots in typhoid fever, 301 Rot, black, of cabbage and allied plants, 625 brown, of tomato, egg plant, and potato, 623 Roup, 265 Rubber stoppers, sterilization of, 26 SACCHAROBtJTYRic putrefactiou, 354 Saecharomyoetes, 472 Sand-fly fever, 546 Saprophytes, 86 Saproph}rtic staphylococcus, 387 streptococcus, 190 Sarcina lutea, 603 Sarcime, 72, 120 Sarcodina, 487 Sarcoma, chicken, 546 Sarcosporidia, 527 Sarcosporidiosis, 527 Sauerkraut, fermentation of, 596 Scarlet fever, 539 Schick reaction, 270 Schizomyoetes, 116 Schizosaccharomyoes octoporus, 473 Schweinesueche, 282, 319 Secondary infections, 133 Secretions, production of, by bac- teria, 100 Septic pleuropneumonia, bacteria of, 319 sore throat, 198 Septicemia, 133 hemorrhagic, 319 bacteria of, 319 modified, typhoid fever as, 299 rabbit, bacteria of, 320 sputum, 209, 213 Septio^mie gangreneuse, 350 Serum, agglutinating power, 175 anthrax, 244 antibacterial and antitoxic, differ- ences between, 15^^« antimeningitis, 221 antipneumococcus, 215 antistreptococcus, 204, 205 antitoxic and antibacterial, differ- ences between, 156 antit3rphoid, 310 Aronson's, 204 bactericidal, 155 INDEX 665 Serum, bactericidal, characteristics of, 155 power, 175 blood-, L6filer's, preparation of, 33 cholera, 437 curative, 204 cytolytic, 154 disease, 178 Flexner-Jobling, 222 hemolytic, 154 hepatotoxic, 154 immune and normal, relation, 155 inactivated, 155 Loffler's, for isolating diphtheria bacillus, 251 lytic action of, 153 Marmorek's, 204 Menzer's, 205 Moser's, 205 nephrotoxic, 154 normal and immune, relation, 155 plague, 329 polyvalent, 204 protecting, 204 treatment of dysentery, 317 of pneumonia, 216 univalent, 204 Yersin's plague, 329 Senun-agar, Wertheim's, 226 Sheep-pox, 546 Shiga's bacillus, 315 Side-chain theory of immunity, Ehr- lich's, 164 Skin diseases caused by fimgus, 483 infection through, 134 Sleeping sickness, 499 Small-pox, 531 and cowpox, relation between, 532 vaccination against, 180, 532 Smith's method of cultivating tubercle bacillus, 373 Soil, bacteria in, 604 nitrogen-fixiation by, 581 Soor, 483 Sore, Oriental, 503 throat, septic, 198 streptococcus, 198 Sour milk, bacteria in, 547 Spaltpiken, 116 Species, bacterial, separation of, by animal inoculation, 48 by heat, 48 Specific agglutinins, 174 Spirillacese, 120 Spirillum, 65 cholerse, 427 allied varieties, 440 animal inoculation with, 435 cultural characteristics, 428 epidemiology, 434 in bUe, 432 in feces, 430 Spirillum cholers in urine, 434 isolation, 430 modes of dissemination, 434 morphology, 427 pathogenesis for man, 432 resistance, 429 toxins from, 436 Danubicus, 440 Deneke's, 442 desulfuricans, 105 gallinarum, 572 Ghinda, 440 Massowah, 440, 442 Metchnikovii, 441 of Finkler and Prior, 442 phosphorescens, 440, 442 tyrogenum, 442 Spirocheeta anserinum, 447 duttoni, 444, 446 gallinarum, 447 kochi, 447 novyi, 447 obermeieri, 420, 442, 443 paUida, 449 recurrentis, 443 refringjens, 450 theileri, 447 Spirochetes, 120, 446 of relapshig fever, 442 characteristics, 443 immunity to, 445 pathogenesis, 445 relationship and nomenclature, 444 Spirochetosis, mode of transmission, 447 Spirophyllum ferrugineum, 104 Spleen, 149 Splenic fever, 233 Splenomegaly, tropical, 501 Spontaneous agglutination, 171 generation, 20, 24 Sporangium, 479 Spores, formation of, 73 of anthrax bacillus. autoclave, 26 by filtration, 46 discontinuous, 27 of feces, 96 of glassware, 24 of instruments, 24 of rubber stoppers, 26 of tubing, 26 Sterilizer, hot-air, Lautenschlager's, 25 steam, Arnold's, 27 Sternberg's bulb for testing thnmal death-point of bacteria, 37 Stewart's cover-glass foroepe, 53 Stitch abscess, 187 Stomach, infection through, 135 Stomatitis, 360 gangrenous, 361 parasitic, 477 Stomoxys as carriers of trypanoeoma evansi, 497 calcitrans in infantile paralysis, 544 Stools, rice-water, 434 Streptobacilli, 72 Streptococcus, 72, 120, 189 as cause of acute articular rheuma- tism, 197 of angina^ 196 of enteritis, 196 of impetigo contagiosa, 195 of pneumonia, 195 of puerperal fever. 194, 196 of suppurative inflammatory con- ditions, 195 I of ulcerative endocarditis, 195 brevis, 190 conglomeratus, 191 cultural characteristics, 189 elective localization of, 125 erysipelas, 193 hemolysin from, 192 hemolytic, as cause of chronic artliritis, 198 HoUandicus, 567 immunity to, 203 in diphtheria, 195 in mdk, 556 intestinal, 196 in otitis media, 195 lacticus, 548 longus, 190 morphologic characteristics, 189 mucosus, 192, 208 pathogenicity for lower animals, 200 for man, 193 phagocytosis of, 203 pneumoniae, 195, 206. See also Pneumococcus. pneumococcus group, transmuta^ tions in, 209 pyogenes, 189, 547 saprophytic, 190 sore tnroat, 198 species of, 201 toxin production, 192 viridans, 191 virulence of, 192 Streptolysin, 193 Streptothrices, 65 Streptothrix, 459 Structure of bacteria, finer, 67 Sugar-cane, germ disease of, 634 INDEX 667 Sulfur, 91 bacteria, 105 purple, 106 red, 106 Summer diarrhea, milk as cause, 657 Sunlight, resistance of tubercle bacil- lus to, 378 Supersensitiveness, 178 Suppurative inflammation, staphylo- coccus in, 184 inflammatory conditions, strepto- coccus as cause, 195 Surra, 496 Susceptibility, natural, 138 Swamp fever of horses, 546 Swine plague, bacillus of, 282 bacteria of, 319 Symptomatic anthrax, 233, 347 Synthetic culture-media, 34 S3rphilis, cutaneous reaction in, 457 micro-organism of, 448 Wassermann's reaction for diagnosis of, 454 Tabanub as carriers of trypanosoma evansi, 497 Tanning, bacteria in, 588 Temperature, influence of, on growth of oacteria, 78 Tertian malarial parasite, 509 Test, biochemical, 34 Calmette's ophthalmic-tuberculin, 394 Hiss' inulin-serum-water, for de- termining pneumococcus, 208 mallein, in diagnosis of glanders, 413 precipitation, 176 tuberculin, in diagnosis of tubercu- losis of cattle, 393 von Pirquet's cutaneous, for tuber- culosis, 394 Wassermann's, for diagnosis of syphihs, 454 Tetanolysin, 346 Tetanospasmin, 346 Tetanus, 339 antitoxin, 344 ' prophylactic value, 347 bacillus, 339. See also BacUlris letani. immunity to, 346 neonatorum, 342 toxin, 344 toy pistol, 342 Texas fever, 520, 521 TheUeria, 520 parva, 523 Thermal death-point of bacteria, 38, 80 Thiothrix, 106 Thirst predisposing to infection, 129 Three-day fever, M6 Throat, sore, septic, 198 streptococcus, 198 Thrush, 477 fungus, 483 Tick, cattle, 522 fever, 446, 520 in East Coast fever, 523 in Rocky Mountain spotted fever, 639 in transmission of relapsing fever, 447 Tinea versicolor, fungus of, 484 Tobacco, bacteria in, 590 curinp; of^ 590 mosaic disease of, 546 petuning of, 591 plant, Granville wilt of, 624 Tomato, brown rot of, 623 Tongue, wooden, 467 Tonsils, infectious material dissemi- nated by, 198 Torula, 473 amara, 551 kefir, 550 Toxemia, 132 Toxins, 110 apparatus for rapid filtration of, 46 extracellular, 114 Toxoids, 113 Toxon. 110 Toxophore atom-group, 113 Toy pistol tetanus, 342 Trachoma, 546, 635 Transmission of infection, 136 Treponema pallidum, 448 staining, 449 pertenue, 457 Trichomycetes, 65 pathogenic, 459 Trichophyton, 484 Tricresol, 95 Tropical splenomegaly, 501 ulcer, 503 Trypanosoma brucei, 496, 497 dimorphon, 498 equinum, 498 equiperdum, 498 evansi, 496 Jjambiense, 499 ewisi, 493, 495 cultivation, 496 rhodesiense, 501 theileri, 498 Trypanosomes, 493 resistance of, to drugs, 501 Trypanosomiasis, 497 Tsetse-fly as carrier of nagana infec- tion, 497 disease, 497 668 INDEX Tubercle bacillus, 369. See also Bo- ciUiu tuberculosis, stain for, 55 Tubercles, root-, 575 Tuberculase, 355 Tuberculin, 393 in tuberculosis, 396 reaction in diagnosis of tuberculosis in cattle, 393 mechanism, 393 ocular, 394 Tuberculinic acid, 371 Tuberculosis, 369 and bovine tuberculosis, relation between, 387 avian, 382 bacillus of, 361. See also Bacillus luberadosis. bovine and human, relation be- tween, 387 Calmette's ophthalmic-tuberculin reaction for, 394 curative inoculations. 395 fowl, 384 immunity to, 395 in lower animals, 380 in man, 378 influence of heredity upon, 391 intrauterine infection, 392 mammalian, 380 of cold-blooded animals, 383 placental infection, 392 predisposing factors, 389 protective inoculation, 395 tuberculin in, 393 Tubing, sterilization of, 26 Tumors, malignant, and blastomy- cetes, relation between, 478 CJoley's mixture in, 193 effect of erysipelas on, 193 plant, 632 T3rphoid bacillus, 287. See also Bacillus typhosus. carriers, 306 dysentery group, 287 fever, 297 as modified septicemia, 300 contact as cause, 305 dust as cause, 305 epidemiology, 300 flies as cause, 304 food substances as cause, 304 Gruber-Widal reaction in, 388 ice as cause, 303 immunity to, 307 milk as cause, 303 rose spots in, 299 serum-therapy, 310 vaccination against, 310 water-supply as cause, 301 germ-carriers. 306 Typhosus, bacillus, 272 Typhus fever, 362 mode of transmission, 365 morpholo^ of, 364 prophylaxis, 367 specific organism of, 362 Udder, bacteria in, 549 Ulcer, tropical, 503 Ulcerative endocarditis, streptococcus as cause, 191 Ulceromembranous angina, 360 Ultramicroscope, 529 Ultramicroscopic virus, 52 Urine, cholera vibrio in, 434 typhoid bacilli in, 298 Uschinsky's culture-media, Frankl's modification, 34 Uta,504 VACcmATioN against anthrax, 244 Asiatic cholera, 437 small-pox, 180 typhoid fever, 311 Vaccine, ^onococcus, 229 pertussis, 338 Vaccinia and small-pox, relation be- tween, 532 Vacuum, formation of, in ana&nobic cultures, 50 Van Ermengem's method of staining flagella, .57 Variations, discontinuous, 121 in bacteria, 121 Variola, 532 and cowpox, relation between, 532 inoculata, 532 Venins, 115 Vibrio cholerse, 427 Vibrion septique, 350 Vincent's angina, 360 Vinegar makmg, 594 mother of, 594, 595 Virulence of bacteria, 130 Virus, ultramicroscopic, 541 Viruses, filterable, 528 diseases due to, 521 modes of transmission, 520 Von Pirquet's method of cutaneous diagnosis of tuberculosis. 394 Vulvovaginitis, gonorrheal, 229 Warts, pathologist's, 387 Wassermann's reaction for diagnosis of S3rphilis, 454 Water analysis, quantitative, 611 standard methods, 608 bacillus coli in, quantitative deter- mination, 612 lactose bile presumptive test, 612 INDEX 669 Water, bacillus typhosus in, 301 bacteria in, 607 effect of freezing on, 616 number of, medium for determin- inff, 6qS purification of, 616 filtration of, 616 Water-glass. 583, 593 Water-supply as cause of typhoid fever, 301 Weil's disease, 423 Welch's bacillus^ 451 method of staining capsules, 56 Wertheim's method of cultivating gonococcus, 226 serum agar, 226 Westbroolrs types <rf bacillus diph- therise, 248 Whooping-cough, 335 influenza-hke bacilli in, 335 pathogenesis, 337 vaccine, 338 Widal-Gruber reaction in typhoid fever, 388 Wildseuche, bacteria of, 319 Wat disease, 622 Granville, of tobacco plant, 624 Wooden tongue, 467 Wright's method of isolating actino- myces, 465 Xerosis bacillus, 249 Yaws, 458 micro-organism of, 458 Yeasts, 472. See also Blastomycetes. Yellow disease of hyacinths, 627 fever, 537 mosquito in transmission of, 537 milk from bacteria, 550 Yersin's plague serum, 329 Ziehl-Neelsgn carbol-fuchsin stain, 55 Zinc chlorid, 95 Zootoxins, 115 Zwischenkorper, 167 Zygospore, 480 Zygote, 512 Zymase, 103 / 1 / -** - m i i 9 r i-^ Y£ 88469. 