None
vasoconstrictor (see also Vessels and Vasomotor) drugs, central, 273-276 peripheral, 278-288 central, 276 vasodilator drugs, peripheral, 288 vasodilatation, renal, hydrsemia as cause of, 359 substances causing, 358, 359 vasodilators (see Vessels and Vaso- motor) vasomotor effects of local applica- tions, 289, 290 vessels, coronary, amyl nitrite, 289 caffeine, 289, 313, 330 renal, drugs acting on, 358, 359 digitalis, action on, 365 intracranial, action of caffeine on, 330 pharmacology of, 270-290 as a whole, effects produced by drugs acting on, 290 ff. CITRATES, cathartic action of, 203 coagulability of blood, action on, 448 CLIMATE, metabolism, effect on, 379 COAL GAS (see Carbon monoxide) COCAINE, accelerators, peripheral, action on, 252 anaesthesia of eye by, 128 antagonism to chloral, 25 central nervous system, action on, 26, 125 cerebral stimulant and depressant, 26 constitution, 121, 131 convulsant action of, 24 distoxication of, 127 elective action on sensory fibres, 123-124 endermic injection of; 128 eye, action and uses in the, 158 gastric secretion, action of, on, 167 general pharmacological action. 122 ff. history, 121, 122 in infiltration anaesthesia, 128 uitra-ocular tension, effect on, 158 metabolism, action on, 382 INDEX 591 COCAINE, nerve blocking by, 123 nerves of special sense, action on, 123 poisoning by, 126 treatment of, 126 principles governing administration, 127 pyrogenic action of, 462, 473 respiration, stimulating actionon,335 sensory nerve-endings, action on, 122 special senses, action on, 123 spinal anaesthesia by, 129 substitutes for, 131 ff. comparative value of, 133 ff. swallowing reflex, action on, 176 synergism between epinephrin and, 159,575 systemic action, 125 therapeutic employment of, 125 toxicology, 126 vessels, action on, 124 in vomiting, 185 CODEINE CHEMISTRY, 31 cough, in treatment of, 38 morphine, differences from, 38 respiratory centre, action on, 340 COD-LIVER OIL, 174 COLD, antiphlogistic action of, 492 heat-regulating mechanism, action on, 453-455 vessels, influence on, 453, 454 COLIC, intestinal mechanism of, 194 COLLAPSE, antipyretics as cause of, 466 atropine in, 25 camphor in, 25 cocaine in, 25 COLLOIDS, obstipant action of, 211 and salts, 570 COLOCYNTH, 192, 206 CONCENTRATION IN BLOOD, 562 CONDIMENTS, stomach absorption, effect on, 173 secretion, action of, on, 167 CONSTIPATION, drugs causing (see Ob- stipants) CONVALLAMARIN, 302 CONVTJLSANTS, 23 temperature, action on, 462, 473 COPAIBA, 367, 486 COPPER, elimination in bile, 170 by intestine, 172 muscular paralysis from, 427 salts, in inflammation, 494 sulphate, emetic action of, 182 phosphorus, antidotef or, 183, 408 toxicity, lack of, 182 CORIAMYRTIN, action on central nervous system, 24 CORNUTINE, 226 CORROSIVES, eye action in, 160. (See also Caustics) CORONARY (see under Circulation, ves- sels, coronary) COTARNINE, uterus action on, 229 GOTO, diarrhoea in, 215 COUGH, morphine group in, 339, 340 COUNTERIRRITANTS, 486 ff. leucocytes, action on, 447 respiration, action on, 341 COUNTERIRRITATION, explanation of ef- fects, 484 CREOLIN, 517 CREOSOTE COMPOUNDS, 526 in tuberculosis, 525-527 CRESOLS, action on liver, 517 as disinfectants, 516, 517 relative toxicity of, 517 CROTON OIL (see Oleum crotonis) CUBEBS, 367, 486 CUMULATION, 563 CURARE, 1 ff. absorption, 5 antagonism between physostigmine and, 9, 152, 572 central nervous system, action on, 4 circulation, action on, 4 excretion, 5 frog, action on, 2 glycosuria, 5 heart, action on, 247 immunity of salamanders to, 573 intestine, action on, 4 mammals, action in, 4 motor nerve-endings, action on, 1 in strychnine poisoning, 19 rigor of muscles, influence on, 424 substances resembling, 8 therapeutic use, 7 CURARINES, 2 CURINE, 2 CYANIDE POISONING, 450, 569 distoxication of, 569 CYTOTOXINS, 560 DEGLUTITION, as affected by drugs, 176 DERMATOL, 216 DIABETES INSIPIDUS, drugs used in treatment, 366 mellitus, 418 DIABETIC COMA, alkalies in, 392 DIAPHORESIS, 371-375 indications for, 375 in renal disease, 375 DIAPHORETICS, central, 372, 373 peripheral, 372 DIARRHCEA, drugs checking (see Obsti- pants) DIETHYL BARBITURIC ACID (see Veronal) DlGALEN, 301, 306 DlGIPURATUM, 306 DlGITALEIN, 301 DlGITALIN, 301, 304 DIGITALIS, active principles, 301 blood-pressure increase from, 292 bodies, differences in actions of, 302 relative cumulative properties of different, 303, 304 vaso-constricting power, differ- ences in their, 288 592 INDEX DIGITALIS, cardiac failure, action in, 310 circulatory collapse, effects in, 323 cumulative effects, 303 deterioration of, 302 distribution of the blood, effects on, 296 diuretic action of, 365 ff. dosage and choice of preparation, 304, 305 extra-systoles, power of causing, 267 heart, action on, 261-267 conductivity, action on, 266, 267 disease, effects in, 296 ff. frog's, action on, 262-264 isolated mammalian, action on, 264, 265 toxic doses, effect on, 266 work, effect on, 293, 294 infusions, rapid deterioration of, 302, 305 intestinal motor function, action on, 188, 191 intravenous administration, 306 kidney vessels, effect on, 287, 299 physiological assay, methods, 301 practical employment of, 301 ff. preparations, variability of, 301 pulse retardation, 292 pulse volume of heart, effect on, 293 regulatory action of, 266, 294 retardation of pulse by, 292 stomach and intestinal movements, action on, 188 summary of actions, 300 theory of action of, 291 toxic action of, 294 vagus, action on, 245, 266, 292 vasoconstriction under clinical con- ditions, 298 ff. vessels, renal, action on, 287, 299 of different organs, quantita- tively different action on, 286,287 peripheral action on, 286-288 vomiting due to, 304, 306 DIGITONINS, 301 DIGITOXIN, 301 importance of size of dose, 564 DIMETHYLXANTHINES, action in kidney, 289 DIONIN, 38 in cough, 340 eye, action in, 161 respiration, action on, 340 DlOXYDIAMIDOARSENOBENZOL (see Sal- varsan) DIPHTHERIA, 553 ff. antitoxin, 556-558 toxin, 555, 556. action on vessels, 483 on heart, 309 DlPROPYLBARBITURIC ACID (see PrOpO- nal) DIRECT ACTION, 6 DISINFECTANTS (see also Antiseptics) specific, 523 ff. in vitro and in corpore, 525 DISINFECTION of instruments, etc., 508 mucous membranes, 508, 509 skin, 507 wounds, 508, 509 DlSTOXICATION, 569 augmentation of power of, 574 DISTRIBUTION, 562 factors affecting, 562 DIURESIS, ascites, effect of relief of, 357 blood flow in kidney as factor in, 357 ff. blood letting, effect on, 354 caffeine group, action on, 360 cardiac stasis, effect on, 357 digitalis group, action on, 365 factors controlling, 354 hydrsemia, effect on, 354 reflex inhibition of, 358 saline infusions, effect on, 354 sugars, action on, 356 tubules, function of, factors influ- encing, 366 vasoconstriction, renal, effect on, 358 urea as stimulant to, 356 vasodilatation, renal, effect on, 359 DORMIOL, 93 DRASTIC PURGATIVES, 207 abortifacient action of, 223, 224 DUBOISINE, pancreatic secretion, action of, on, 168 ECGONINE, 132, 133, 154 ECHUYIN, 302 EHRLICH'S side-chain theory, 550 ff. ELECTIVE ACTION, 5 ELIMINATION of drugs in milk, 220 rapidity of, 562 EMESIS, 181-185 drugs sometimes causing, 185 treatment of, 185 EMETIC CENTRE, depressants of, 178 EMETICS, centrally acting, 179, 180 expectorant action of, 179, 343 peripheral, 181-185 EMETINE, 181, 182 EMODIN, 207 ENEMATA, 194 ENZYMES, as caustics, 492 EPHEDRINE and pseudo-ephedrine, 159 EPINEPHRIN, 279-285 accelerator, peripheral, action on, 252 analeptic action of, 321, 322 ansesthesia, local, use in, 280 antiphlogistic action of, 496 arteriosclerosis, a cause of, 282 asthma, action in, 346 blood-pressure, effects on, 281 in chloroform death, 65, 320 INDEX 593 EPINEPHRIN, circulatory failure, in treat- ment of, 320 ff. coagulability of blood, action on, 448 constitution, 279 coronary vessel, action on, 280 diuresis, action on, 358 elimination, 282 evanescence of action, cause of, 282 eye, action in, 159, 282 fibrillation of heart, a cause of, 322 glycosuria, 282, 419 in haemorrhage, 321 haemostatic action of, 280 heart, action on, 260, 261 in heart failure, 320, 321 hepatic function, action on, 171 hypertension, a cause of, 323 ff. intestinal motor function, action on, 191 intravenous use of, 321 kidney, action on vessels of, 280 and pancreas hormone, 568 pulmonary vessels, action on, 280 pyrogenic action of, 462, 463 reaction in pancreatic disease, 159 respiration action on, 282 salivary glands, effect on, 164, 282 seat of action, 282 significance (physiological), for the blood-pressure, 284 in shock, 321 spinal anaesthesia, in collapse from, 321 stomach movements^ action on, 188 subcutaneous injections, effects of, 322 sweat glands, lack of action on, 372 and the sympathetic nerve-endings, 141 eynergism between cocaine and, 159, 160, 575 tests for, physiological, 283 uterine movements, action on, 222, 223, 229 vagus centre, effect on, 282 vascular depression, in treatment of, 320 ff. vasomotor paradox, 226 vessels, action on, 279-283 vascular paresis, in treatment of, 320 ff. EPSOM SALT (see Magnesium sulphate, also Cathartics, saline) ERECTION, 219 ERGOT, 224-228 active principles of, 225-227 instability of, 227 cock's comb, action on, 226 in hemorrhage from uterus, 228 physiological assay of, 227 preparations of, 228 therapeutic uses of, 228 vasoconstrictor action of, 228 ERGOTIN, stomach and intestinal move- ments, action on, 188 ERGOTISM, 224, 225 ERGOTOXIN, 225, 226, 227 circulation, action on, 226 sympathetic nerve-endings, action on, 142 ERYTHROL TETRANITRATE, 329 ERYTHROPHLEIN, 302 ESCHAROTICS, 491 ff. ESERINE (see Physostigmine) ETHER, 49-55 ETHER ANAESTHESIA, after effects, 73, 74 blood-pressure, effects on, .62 asthma, action in, 345 blood cells, action on, 56 chemistry of, 53 circulation, action on, 60 ff. circulatory failure, in treatment of, 317 concentration in air inspired, 72, 73 in blood during anaesthesia, 70, 7 1 excretion, 55 general action, 54 heart, stimulating action on, 257, 258 local action, 54 anaesthetic action, 54, 56 respiration, action on, 59, 335 a respiratory stimulant, 335 synergism, 79, 576 vasomotor centres, action on, 62 vessels, action on, 275 ETHEREAL OILS, abortifacient action of. 224 antiphlogistic action of, 496 carminative action, 211 diuretic action of, 359 gastric secretion, action on, 167 kidney secretion, action, 359 ETHYL BROMIDE anaesthesia, 83 chloride, local anaesthesia by, 118 ETIOTROPIC pharmacological agents, 497 ff. EUCAINE, 133 B, 133 relative toxicity of, 134 action on vessels, 135 EUMYDRINE, mydriatic action, 157 EUONYMIN, 206, 302 EUPHTHALMINE, mydriatic action, 157 EUQUININE, 476 EUROPHEN, 520 EXCITABILITY, exaltation of, 44 EXPECTORANTS, 342 ff. mode of action, 342 nauseant, 343 effect on alveolar air, 339 EYE, antiseptics in, 160 astringents in, 160 corrosives in, 160 pharmacology of the, 144 ff. FELIX MAS, 521 causing toxic amblyopia, 144 594 INDEX FENNEL, carminative action, 211 FERRATIN, 442 FEVER, mechanism of, 459-463 puncture hyperthermia, 460, 461 significance of, 473-475 substances causing, 462 FIBROLYSIN, 489 FILICIC ACID, 522 FILICIN, 522 FORMALDEHYDE, astringent action, 493 as disinfectant, 507 FRANGULA, 208 FUNCTIONAL CONDITION of organs, 566 GALL-BLADDER, atropine, action on, 169 pilocarpine, action on, 169 GAMBOGE, 206 GASTRIC HYPERSECRETION, inhibition of, 167 motility (see Stomach, motor func- tion of) secretion, 165T167 acids, action of, on, 165 albuminoses, action of, on, 165 alkalies, action of, on, 165 atropine, action of, on, 166 bismuth, action of, on, 167 bread, action of, on, 165 choline, action of, on, 166 cocaine, action of, on, 167 condiments, action of, on, 167 fats, action of, on, 165 lime water, action of, on, 167 local anaesthetics, action of, on, 167 magnesia, action of, on, 167 meat extractives, action of, on, 165 morphine, action of, on, 166 protectives, action of, on, 167 GELATINE, coagulability of blood, action on, 448 GENITAL GLANDS, metabolism, influence on, 398 GLAUBER'S SALT (see Sodium sulphate, also Cathartics, saline) GLAUCOMA, effect of atropine in, 155 of cocaine in, 158 of physostigmine in, 150 GLOTTIS, drugs acting on spasm of, 345 GLYCERINE, intestine, action on, 194 GLYCOSURIA, asphyxial, agents causing, 418 drugs causing, 418, 419 phloridzin, 419 renal, drugs causing, 419 suprarenal, 419 thyroid substances, causing, 397 GLYCOSURIAS, toxic, 418 GLYCURONIC ACID, 420 GOUT, atophan in, 421 alkalies in, 390, 391 GUAIACOL, 526 compounds, 526, 527 ELEMOLYTIC TOXINS, 452, 559 HAEMOLYSIS, 451 ff., 559 as measure of intensity of pharma- cological action, 564 HALOGEN SALTS, elimination by intes- tines, 172 HASHISCH, 41 HEADACHES, antipyretics in, 475 HEART (see under Circulation) HEAT, heat-regulating mechanism, action on, 455, 456 action on vessels, 290 regulating centres, abnormal func- tion in fever, 459, 460, 461 cooling a stimulant to, 457 depression of, 458 location of, 458 overheating a depressant of, 458 stimulation of, 457 regulation, pharmacology of, 453- 480 physiology of, 453-458 HEDONAL, 95 HELLEBOREIN, 302 HELMITOL, 367 HEROIN, respiration, action on, 38, 340 HEXABROM - DIOXY - DIPHENYLCARBINOL, 525 HEXAMETHYLENAMINE, elimination bv bile, 170 salivary glands, 165 as urinary disinfectant, 367 HIDROTICS (see Diaphoretics) HIPPOL, 367 HIRUDIN, 448 His, bundle of, digitalis's action on, 266, 267, 295 HOMATROPINE, mydriatic action, 157 HOMOEOPATHY, 561 HYDR^EMIA, effect on diuresis, 354 produced by salts, 354, 355 HYDRASTIN, blood-vessels, action on, 229 uterus, action on, 229 HYDRASTININE, blood-vessels, action on, 229 uterus, action on, 229 HYDRASTIS, uterus, action on, 229 HYDROCARBON NARCOTICS, 43 ff. general action, 84 side actions, 85 of aliphatic series, heart, 'depressant action on, 252, 253 chemical constitution and pharma- cological action, 98 ff. depth of sleep, effects on, 86, 87 halogen-free compared with .halo- gen-containing, 93 influence of halogen groups in, 99 motor function, varying action on, of different, 87 HYPOPHYSIS EXTRACTS, uterine contrac- tions, action on, 223, 230 metabolism, influence on, 398 HYPOSULPHITES, in nitril posioning, 569 HYPOTHYROIDISM, 396 ICHTHYOL, 518 IDIOSYNCRASY, 578. (See also Hyper- susceptibility, 578, and Anaphylaxis, 580) IMMUNITY, 573 active and passive, 544 cellular, 573 INDIRECT ACTION, 6 INFILTRATION ANAESTHESIA (see under Cocaine) INFLAMMATION, excitation of, 481-492 influence of caustics on, 483, 484 of irritants and counterirri- tants on, 482 of necrotizing agents on, 483, 484 of nerves on, 481, 482 of vascular poisons on, 483 inhibition of, 492-496. (See also Antiphlogistic agents, etc.) nature of, 481 pharmacology of, 481-496 INFUSIONS, blood, in circulatory failure, 318 effect on concentration of blood, 437 in carbon monoxide poisoning, 450 saline, blood regeneration, in- fluence on, 435 blood volume, effect on, 435 circulatory • failure, in treat- ment of, 318 haemorrhage, value in, 319 toxaemias, value in, 319 INHALATIONS, action on lungs, 341 antiseptic, 341 INHIBITION, removal of, 44 INSOMNIA, causes, 85 INSUSCEPTIBILITY, 573, 574 to cantharidin, 574 to emetics, 574 of morphinist to cocaine, 574 of mice to CO, 574 of young animals to strychnine, 574 INTERNAL SECRETIONS, metabolism, in- fluence on, 398 INTESTINAL DISINFECTION, 201, 204, 520 juice, secretion of, 171, 172 INTESTINE, absorption in, 173 large, cathartics acting on, 207 ff. motor function, 190 ff. small, cathartics acting on, 205 ff. elimination by, 172 IODIDES (see also Iodine) in asthma, 347 in atheroma, 402 elimination by saliva, 164 expectorant action of, 343 in metallic poisoning, 402 in neuralgia, 402 in syphilis, 401 viscosity of blood action on, 448 IODINE COMPOUNDS (see also Iodine and Iodides) as counterirritant, 488 ion action of, 399 local action, 398, 488 metabolism, action on, 398-402 mucous membranes, action on, 400 nutrition, action on, 400 poisoning from, 488 scrofula, action in, 401 skin, action on, 400 systemic actions, 399-402 theory of, action of, 400, 401 thyroid gland, action on, 400 IODIPIN, 402 IODOFORM, 518, 519 toxicology, 519 idiosyncrasy to, 580 substitutes for, 519, 520 IODOL, 520 IODOTHYRIN, 395. (See also Thyroid substances) hepatic functions, action of, on, 171 IPECAC, 181, 182 in dysentery, 181, 182 emetic action of, 181 expectorant action, 343 IRIS, pharmacology of, 145-159 IRON, alimentary canal, behavior in, 442 blood, actions on, 435-443 comparative value of different prep- arations of, 442 content of foods, 441 excretion of, 172, 438 in food stuffs, 441 inorganic, absorption of, 439 effect on iron balance, 438 preparations, 442 relative superiority, 440 ff. transformation into haemoglobin, 439 kidney, lack of action on, 443 metabolism, action on, 415 non-toxic by mouth, 439 organic preparations, 442 relative inferiority, 440 transformation into haemoglobin, 440 596 INDEX IRON salts in inflammation, 494 sulphate, as deodorant, 507 tonic effect, 441 toxicology, 442, 443 IRRITANTS, phlogistic effects of, 482 ISOFORM, 520 ISOPRAL, 93 ISOVALERYLUREA, halogen compounds, 100 ITROL, 513 JABORANDI, 373 JALAP, 206 JAMBUL in diabetes, 418 JUNIPER, oil of, 486 JUNIPERUS SABINUS, abortifacient action of, 224 KAIRINE, 477 KALAHARI arrow poison, 483 KAMALA, 523 KIDNEY, blood flow in, estimation of, 358 vessels, digitalis action on, 365 KINO, 214 Koosso, 522 Kousso, 522 KOUSSOTOXIN, 522 KRAMERIA, 214 LACTAGOGUES, 220 LEAD ACETATE, absorbability of, 216 astringent action of, 216 elimination in bile, 170 by intestine, 172 in saliva, 165 muscular paralysis from, 427 organic compounds, toxicity of, 533 salts, in inflammation, 494 vascular crises, a cause of, 325 LECITHIN, metabolism, effect on, 417 LEUCOCYTES, drugs influencing, 446, 447 LIME (see also Calcium) coagulability of blood, action on, 447 as disinfectant, 506 water, alimentary canal, action in, 217 gastric secretion, action of, on, 167 LIVER, functions of, and epinephrin, 171 and iodothyrin, 171 and pancreatic internal secre- tion, 171 LOBELINE, asthma, action in, 345 emetic action, 180 Diration, stimulating action on, LOCAL ANESTHETICS, gastric secretion, action of, on, 167. in diabetes, drugs affecting, 418 dehydration, action on, 387 in fever, 459, 460 functional activity, influence of, 381 iodides, influence of, 398 INDEX 597 METABOLISM, light, action on, 382 mineral, 418 osmotic changes, action on, 384, 385 pharmacology of, 377 phosphorus, 405 physiology of, 377-381 quinine, influence on, 403 of purines, 421 special phases of, 417 ff. stimulation of, 378-380 temperature of body, influence on, 382 thyroid substances, influence on, 395 water ingestion, action on, 384-386 METALLIC SALTS, antiseptic actions, 514, 515 astringent action, 215 ff. as caustics, 491 METH^EMOGLOBIN, drugs causing forma- tion of, 451 METHYLATROPINE, 157 METHYL CHLORIDE, local anaesthesia by, 118 ecgonine, 131 METHYLENE BLUE, elimination in bile, 170 MIGRAINE, nitrites in, 329 MIGRAININE, 479 MILK (see Mammary secretion, 220) MIOSIS due to arecoline, 153 choline, 153 muscarine, 153 nicotine, 153 physostigmine, 148 ff. picrotoxine, 147 pilocarpine, 153 MIOTICS, centrally acting, 147 peripheral, 147-153 MODE of administration, 562 MORPHINE, as analgesic, 36 antagonism to atropine, 336 antidotes for, 36 antipyretic action, 465 bladder, action of, on, 34 as cerebral stimulant, 33 / chemistry of, 30, 31 circulation, action of, on, 34 compared with ether and chloro- form, 58 constipating action of, 193 constitution, 30 convulsive action of, 32 cough, effects on, 37, 339 deglutition, effect on, 176 a digitalis of the respiration, 339 elimination by intestine, 36, 40, 172 by saliva, 165 by kidney, 40 by stomach, 35 emetic action, 34, 180 euphoric action, 33 fate in body, 40 foetus, action on, 35, 575 frog, action on, 31 MORPHINE, gastric secretion, action of, on, 166 habituation, causation of, 39, 574 higher animals, action of, in, 32 as hypnotic, 37 insusceptibility acquired by cerebral cells, 574 intestinal motor function, action on, 192 intestinal secretion, 193 lethal dose, 34 miotic action, 34, 147 motor areas, action on, 32, 33 reactions, action on, 33 as narcotic, 29 pain, action on, 32 pancreatic secretion, action on, 168 poisoning, acute, 34 acute treatment of, 35 pupil, action on, 34, 147 respiratory centre, action of, on, 33, 337 ff. and scopplamine, 42, 79, 575 scopolamine anaesthesia, 79 source of, 30 stomach absorption, effect on, 173 movements, action on, 188, 189 secretion, 166, 189 synergism with ether or nitrous oxide, 575 tetanic action of, 31, 32 therapeutic uses, 36 uterine contractions, action on, 223 variability of effects in different animals, 32 vessels, action on, 276 MORPHINISM, 39 MOTOR NERVE ENDINGS, 1 ff. depression of, 1 ff. stimulation of, 9 ff. MUCILAGINOUS SUBSTANCES, obstipant action of, 211 MUSCARINE, antagonism to atropine, 249, 250, 569, 571 autonomic nervous system, action on, 142 constitution, 248 heart action on, 246-249 miotic action of, 153 poisoning, 251 salivary secretion, action on, 164 sweat glands, action on, 372, 373 MUSCLES, anatomy and physiology, 422- 424 depressant drugs, 427 involuntary (see Pharmacology of Vegetative System) ionic actions on, 422 pharmacology of, 422-434 red, function of, 423 stimulants of, 428 ff. water content, influence of, 422— 423 white, function of, 423 598 INDEX MUSHROOMS, hsemolysin in, 452 poisoning, 251 MUSK, heart, action on, 257 MUSTARD, oil of, 488 MYDRIATICS, centrally acting, 147 peripherally acting, 153 ff. NAPHTHALIN, as intestinal antiseptic, 521 in skin diseases, 518 NARCOSIS (see also Anaesthesia,- Hypnot- ics, etc.) theory of, 100 ff. distribution coefficients, 105, 106 of narcotics in organism, 103 elective absorption by nervous system, 102 importance of lipoid solubility, 101 other types and causes of nar- cosis, 108 side actions of narcotics, 107 NARCOTICS of alcohol group, in vascular crises, 325, 326 vasodilator action, peri- pheral, 288 of alcohol-chloroform group (see Narcotics of Alcohol group, and Narcotics of Aliphatic series) metabolism, influence on, 382 respiratory sedative action of, 337 vessels, action on, 276 NARCOTINE, 30, 37 NERVE BLOCKING, 117, 129 NEURALGIAS, antipyretic group in, 475 NEURONAL, 97 NICOTINE (see also Tobacco) autonomic nervous system, action on, 140 ff. central actions, 373 heart, action on, 246, 247 intestinal motor function, action on, 191 miotic action of, 153 stomach movements, action on, 187 sweat glands, action on, 373 uterine movements, action on, 222, 223 NIGELLINE, sweat glands, action on, 372 NIRVANIN, 132 NITRILS, distoxication of, 569 NITRITE POISONING, 216, 451, 569 from saltpetre, 216 from bismuth subnitrate, 216 NITRITES (see also Amyl nitrite) in angina pectoris, 327-329 asthma, use in, 346 blood, action on, 451 cerebral vessels, action on, 329 coronary arteries, dilating action on, 327 various, differences between, 329 in vasoconstriction, 327 NITROUS OXIDE, anaesthesia, 80 ff. narcotic action, cause of, 108 NITROUS OXIDE, oxygen anaesthesia, 81 NOSOPHEN, 520 NOVOCAINE, 132 relative toxicity, 133, 134 superiority of, 134, 135 OBSTIPANTS, 211 ff. mode of action, 211 OILS, ethereal, action on gastric secre- tion, 167 on kidney, 359 OLEATES, biliary secretion, action on, 170 OLEO-CROTONIC ACID, 205 OLEUM CROTONIS, cathartic action of, 203 OLEUM MORRIHLE, 174 ricini, cathartic action of, 205 OPIUM (see also Morphine) alkaloids other than morphine, 30,37 composition of, 30, 37 diabetes insipidus, in treatment of, 366 in diabetes mellitus, 418 eating, 41 therapeutic uses of, 37 ORTHOFORM, 132, 134 new, 132 OVARIAN EXTRACT, artificial menopause, action on, 218 OVARIES, choline, action on, 218 uterus, etc., influence on develop- ment of, 218 OUABAIN, 302, 307 OXALATES, coagulability of blood, action on, 448 distoxication by calcium, 569 intestine, action on, 175 OXALURIA, 421 OXIDATION, substances inhibiting, 404 ff. OXYANTHRAQUINONE DERIVATIVES, 207 OXYGEN in carbon monoxide poisoning, 450 inhalations, 332, 333 lack of, effect on respiration, 333 tension, blood, influence on, 446 metabolism, influence on, 404, 405 respiratory centres, influence on, 332 OXYTOXICS (see also Uterine contrac- tions, drugs influencing) PANCREAS, internal secretion of, 169 hepatic function, action on, 171 PANCREATIC SECRETION, 168, 169 atropine, action of, on, 168 choline, action of, on, 168 duboisine, action of, on, 168 morphine, action of, on, 168 pilocarpine, action of, on, 168 PANTOPON, 37 PAPAIN, as caustic, 492 PAPAVERINE, 30 PARAFFIN ENEMATA, 194 PARAFUCHSIN, 536 INDEX PARAHYDROXYPHENYLETHYLAMINE, 226 PARALDEHYDE, 87, 93 PARAMIDOPHENOL, 478 PARANEPHRIN (see Epinephrin) PARASYMPATHETIC nervous system (see Autonomic nervous system) PARATHYROIDS, 396 PELLETIERINE, 523 toxic amblyopia from, 144 PENETRATING POWER, 561 PENTAMETHYLENEDIAMINE in ergot, 225 PERMANGANATE OF POTASH (see Potas- sium permanganate) PERONIN, 38, 161, 340 eye action in, 161 respiration, action on, 340 PHARMACOLOGICAL ACTION, factors and principles governing, 5 nature of, 6 reactions, factors affecting, 561 ff. PHENACETIN (see Acetphenetidin) PHENOL, antipyretic action of, 462, 473 antiseptic actions, 514, 515 gangrene from local application of, 119 glycuronic acid and, 420 kidney, action on, 516 local action, 515 anaesthetic action of, 119 poisoning, 515 treatment of, 516 urine, action on, 516 PHENOLPTHALEIN, 208 PHENOLTETRACHLORPHTHALEIN, 209 PHENYL SALICYLATE (see Salol) PHLOGOGENIC AGENTS, 483 ff. classification of, 484 PHLORIDZIN GLYCOSURIA, 366, 419 PHOSPHORUS, blood, action on, 406 bone, action on, 406, 407 metabolism, action on, 405-408 poisoning, treatment of, 408 therapeutic uses of, 408 toxicology, 407 PHYSOSTIGMINE ACCOMMODATION, action on, 149 antagonism between atropine and, 152, 572 curare and, 9, 152, 572 autonomic nerve endings, 150 ff. nervous system, 142 central actions, 152, 373 glaucoma, action in, 150 heart, action on, 152 seat of action in, 251 intestinal motor function, action on, 190 intra-ocular tension, action on, 149 miotic action, 148 ff. motor nerve-endings, 9 mucous glands, action on, 151 muscles, action on, 9, 151 respiration, action on, 152 salivary secretion, action on, 151, 164 PHYSOSTIGMINE, stomach movements, action on, 187 sweat secretion, action on, 372, 373 uterine movements, action on, 222 PHYTOTOXINS, 547 PICROTOXIN, antipyretic action of, 462, 473 autonomic nervous centres, action on, 142 convulsant action of, 23 diaphoretic action, 372 medulla, action on, 24 vasoconstrictor and vagus centres, action on, 274 PILOCARPINE/ absorbant effects of, 375 antagonism to atropine in sweat glands, 373, 572 biliary secretion, action on, 169 bronchial glands, action on, 343 central nervous system, action on, 374 collapse from, 374, 375 diaphoretic actions, 373 eye, action on, 153 general actions, 374 heart, action on, 247 intestinal motor function, action on, 190 leucocytes, influence on, 447 mammary secretion, action on, 220 metabolism, action on, 374 pancreatic secretion, action of, on, 168 salivary secretion, action on. physiology of, 348-354 secretion, blood flow, influence on, 350 glomeruli, role played by, 350 impaired permeability of glom- eruli, influence on, 351 sodium chloride group, influ- ence on, 350 theory of, 349 ff. tubules, role played in, 351, 352 vasodilators, 360 ff. REPRODUCTIVE ORGANS, pharmacology of, 218 RESINOUS ACIDS, cathartic, 206 RESORCIN, as antiseptic, 517 RESPIRATION, counterirritants. action on, 341 pharmacology of, 332 sedatives (central) of, 337-340 stimulants (central) of, 334 ff. RESPIRATORY CENTRES, reflex stimula- tion of, 336 RETINA, pharmacology of the, 144, 145 action of carbonic acid on, 144 of chloroform on, 144 strychnine on, 145 santonin on, 145 augmentors of excitability of, 145 hypersesthesia of, drugs" relieving, 144 RHAMNUS PURSHIANA (see Cascara) RHATANY, 214 RHEUM (see Rhubarb) RHUBARB, 208 RHUS TOXICODENDRON, phlogogenic ac- tion, 483 RINGER'S SOLUTION, 388 RONTGEN RAYS (see X-rays) ROTTLERIN, 523 RUBEFACIENTS, 482, 483 SABROMIN, 115 SACRAL ANAESTHESIA, 120 SAJODIN, 402 SALICYLATES, antipyretic action of, 472 bile, action on, 170 blood, action on, 451 carbon dioxide's influence on, 530 in diabetes, 366, 418 diaphoretic action, 374 kidney, action on, 531 leucocytes, action on, 447 metabolism of proteid, action on, 472 uric acid metabolism, action on, 421 SALICYLIC ACID, antiseptic action, 518 group of antipyretics, 480 as intestinal antiseptic, 521 in rheumatism, 529-531 uterus, action on, 224 INDEX 601 SALICYLISM, 480, 530, 531 SALINE INFUSIONS (see Infusions, saline) SALIPYRINE, 479 SALIVARY GLANDS, elimination by, 165. (See Salivary secretion) secretion, pharmacology of, 162-165 acids, action on, 163 atropine, action on, 164 bitters, action on, 163 choline, action on, 164 direct stimulation of, 163 inhibition of, 164 mercury, action on, 164 muscarine, action on, 164 physostigmine, action on, 164 pilocarpine, action on, 164 reflex stimulation of, 163 tobacco, action on, 164 SALOL, as intestinal antiseptic, 521 renal antiseptic action, 367 SALT-POOR DIET, diuretic action of, 356 SALTS, acid, local action, 394 diuretic action of, 355 as diuretics, contraindications for, 356 neutral (see also Sodium chloride group) alkali loss produced by, 388 metabolism, action on, 387 of proteid, action on, 387, 388 skin, action on, 487 stomach, effect on movements of, 187 SALVARSAN, 537 ff. constitution, 536 employment in man, 537, 538 elimination, 538 in relapsing fever, 537 in syphilis, 538 SANDALWOOD, 367, 486 SANTONIN, antipyretic, action of, 462, 473 as anthelmintic, 523 convulsant action of, 24 toxicology, 523, 524 SAPONIN, haemolysis by, 452 pharmacological actions, 344 SAPROL, 517 SCAMMONY, 206 SCILLAIN, 302 SCLERERYTHRIN, 225 L-SCOPOLAMINE, 154 ScopOLAMiNE, chemistry of, 27 eye, action in, 157 as a hypnotic, 27, 28 identity with hyoscine, 27 motor centres, action of, on, 28 mydriatio action, 157 relation to atropine, 27 synergisni, with morphine, etc., 42, 79, 82, 575 toxic action, 28 uterine coritractions, action on, 223 variability of preparations of, 29 SCURVY, r61e of neutral salts in, 388 SEA BATHS, metabolism, effect on, 379 SEA-SICKNESS, chloral, etc., in, 326 SECALIN TOXIN, 226 SECONDARY ACTION, 6 SEIGNETTE SALT, 202 SENEGA, expectorant action, 344 SENNA, 207 SENSORY NERVE-ENDINGS, pharmacolojrv of, 117 nerves, reflex effects of stimulation of, 117 SEPSIN, capillary dilating actipn of, 289 SEQUARDINE, 434 SERA, bactericidal, 558 SERUM THERAPY, 546 ff. SIDE-CHAIN THEORY, 550 SILVER NITRATE, absorption of. 216 astringent action in alimentary canal, 216 in inflammation, 494 organic compounds, 514 salts as antispetics, 513, 514 chemotactic power, 513 SINIGRIN, 488 SMELLING SALTS, 336 SNAKE VENOM, phlogogenic action, 483 sera against, 551 SODA (see Sodium bicarbonate) SODIUM BICARBONATE, biliary secretion, action on, 170 gastric motility, action on, 186 chloride, diuresis, action on, 355, 356 fever, 463 group as expectorants, 343. (See also Salts, neutral) and vegetable diet, 449 ions, action on muscles, 422 nitrate, nitrite action of, 330 phosphate, 202 salicylate, therapeutic effects, 480 sulphate, 201 coagulability of blood, action on, 448 SOZOIODOL, 520 SOZOIODOLIC ACID, 516 SPANISH FLY (see Cantharidin) SPHACELIC ACID, 226 SPHACELOTOXIN, 226 SPHYGMOGRAMS, 235 SPINAL ANALGESIA, by cocaine, etc., 129 by magnesium salts, 110 STASIS, cardiac, 233 STIMULATION, significance of, 43, 44 STOMACH, absorption in, 172 alcohol, effect on, 173 bitters, effect on, 173 carbonic acid, effect on, 173 condiments, effect on, 173 colloids, effect on, 173 motor function of, 186-189 autonomic drugs, action on, 187 602 INDEX STOMACH, secretory function of (see Gas- tric secretion) STOVAINE, 133, 134, 135 STROPHANTHIN, 302, 304, 306, 307, 310 in circulatory collapse, 323 ' intravenous use, 306, 323 STROPHANTHUS (see Strophanthin) STRYCHNINE, antidotal action of, 20 brain and medulla, action of, on, 17 chemistry of, 13 circulation, action of, on, 18 "curare," action of, 19 death, cause of, 19 in diabetes insipidus, 366 diaphonetic action, 372 diuresis, action on, 358, 366 excretion of, 21 frog, action in, 13 heart, action on tone of, 311 higher animals, action on, 16 intestinal motor function, action on, 191 kidney vessels, action on, 273 metabolism, action on, 379 muscular function, effect on, 424. 427 paralytic action of, 18 poisoning, treatment of, 19 respiration, action on, 18 a respiratory stimulant, 335 retina, action on, 145 seat of action of, 14 source of, 12 special senses, action on, 18 stomach tone, action on, 188 test for, 13* theory of action of, 15 therapeutic uses, 20 toxicology, 19 vascular depression, in treatment of, 311 vagus centre, action on, 245 vasomotor centres, action of, on, 18, 273 STYPTICIN, 229 STYPTOL, 229 SUBLAMINE, 513 Succus ENTERICUS (see Intestinal juice, 171) SUDORIFIC (see Diaphoresis) SUGAR, in muscular fatigue, 431 SULPHATES, in lead poisoning, 201 in phenol poisoning, 201, 516 SULPHIDES, alkaline, cathartic action of, 209 skin, action on, 487 SULPHITES, as preservatives, 510 SULPHO-CARBOLATES, 516 SULPHONAL, 95, 96, 98 blood, action on, 451 group, 94 ff. SULPHONETHYLMETHANE (see Tlional) SULPHONMETHANE (see Sulphonal) SULPHUR, cathartic action of, 209 skin, action on, 487 toxic action of, 210 SULPHURETTED HYDROGEN, 210 antidote in metallic poisoning, 210 bronchial mucous membrane, action on, 210 local action, 210 SUPPURANTS, 489 ff. SUPRARENAL (see also Epinephrin) SUPRARENALS, metabolism, role in, 398 SWEAT (see Diaphoresis and Antisu- dorifics) physiology of, 369-371 secretion of, 369-376 astringents, action on, 376 inhibition of, 375, 376 SYMPATHETIC NERVOUS SYSTEM, 136- 141 anatomy and physiology of, 137, 138 antagonism between auto- nomic nervous system and, 140 SYNERGISM, 575 of antiseptics, 576 between cocaine and epinephrin, 159, 575 ether and chloroform, 79, 576 magnesium sulphate and chlo- roform, 575 morphine, scopolamine, and ether, 79 morphine and scopolamine, 79, 82, 575 of opium alkaloids, 576 of trypanosome remedies, 576 SYNERGISTIC ACTIONS on temperature, 473 SYPHILIS, iodides in, 401 mercury in, 539-543 SYSTEMIC ACTION, 5 TAMARIND, 203 TANNALBIN, 215 TANNIC ACID (see Tannin) TANNIGEN, 215 TANNIN, 214 absorption, 214 action after, 214 alimentary canal, action in, 214 compounds of, 214 dysentery action in, 182, 214 TANNINS, 213 TANNOCOLL, 215 TANSY, abortifacient action of, 224 TARTAR EMETIC (see Antimony and Po- tassium tartrate and antimony) TEMPERATURE OF BODY, respiration, action on, 333 drugs affecting, influence on metab- olism, 382 INDEX TESTICLES, influence on secondary sexual characteristics, 219 TESTICULAR EXTRACTS, muscles, influ- ence on, 433 TETANUS, 552 ff. antitoxin, 554 drugs causing, 13 incubation period, 553 toxin, mode of distribution, 553 TETRABROM-O-KRESOL, 525 TETRAETHYL-AMMONIUM, 8 J3-TETRAHYDRONAPHTHYLAMINE, 159 TETRAHYDRONAPHTHYLAMINE, pyrogenic action of, 462 TETRAMETHYLENEDIAMINE in ergot, 225 in ammonium, 8 TETRONAL, 95, 98 THALLIN, 477 THEBAINE, 304 THEINE (see Caffeine, 314) THEOBROMINE (see also Caffeine and C. group) accelerator, peripheral, action on, 252 in angina pectoris, 330 constitution, 360 digestive system, action on, 364 diuretic action of, 364 preparations of, 364 in vascular crises, 331 vessels, action on, 274, 289. 330 dilator action on cerebral, cor- onary and renal, 289 THEOCIN (see Theophylline) THEOPHYLLINE, constitution, 360 digestive system, action on, 364 diuretic action, 364 vessels, action on, 274. (See also Caffeine and Theobromine) THIOSINAMINE, 489 THRESHOLD DOSE, 564 THUJA OCCIDENTALS, abortifacient ac- tion of, 224 THYMOL, as antiseptic, 517 anthelminti'c, 524 as intestinal antiseptic, 521 poisoning from, 524 in uhcinariasis, 524 THYROGLOBULIN, 395. (See also Thy- roid substances) THYROID SUBSTANCES, estimation in blood, 397 glycosuria, resulting from, 397 in hypothyroidism, 396 metabolism, influence on, 395- 397 in obesity, 396, 397 poisoning from, 397 THYROIODIN, 395. (See also Thyroid substances) TOBACCO (see also Nicotine) as abortifacient, 223 amblyopia, 144 poisoning, circulation in, 247 TOXINS, nature and properties, 646, O4i passage along nerves, 545, 553, 556 vessels, action on, 270 TOXOIDS, 550 TRANSFUSION (see Infusions) TRIFERRIN, 442 TRIONAL, 95, 98 TROPAIC ACID, constitution, 154 TROPACOCAINE, 131. 134 action on vessels, 135 TROPINE, constitution, 153 TRYPAN RED, 536 TRYPAROSAN, 536 TRYPSIN, as caustic, 492 TUBERCULIN, phlogogenic action, 483, 490 treatment, 546 TURPENTINE, 486 action in lungs, 487 hi phosphorus poisoning, 408 URETHAN, 94 in asthma, 345 URACIL in ergot, 225 UREA, diuretic action of, 356, 359 renal secretion, influence on, 350 URIC ACID SOLVENTS, 421 URINARY ANTISEPTICS, 367 URINE, alkalies, action on, 368 secretion of (see Renal secretion) UROTROPINE (see Hexamethylenamine) UTERINE MOVEMENTS, atropine, action on, 222 drugs influencing — centrally or reflexly, 223, 224 pharmacology of, 221 ff. pilocarpine, action on, 222 UTERUS, gravid and non-gravid, differ- ence in pharmacological reactions, 222 UVA URSI, 367 VAGUS (see Circulation, Heart, Inhibi- tory nerve) VALERIAN, action on central nervous system, 115 in diabetes insipidus, 366 VALTDOL, 115 VALVYL, 115 VASCULAR (see under Circulation) VASOMOTOR, etc. (see under Circula- tion) VASOTONIN, 331 VEGETATIVE NERVOUS SYSTEM, 136 ff. anatomy and physiology, 136-138 action of nicotine on, 140 VERATRINE, antipyretic effects, 426, 466 blood-pressure, action on, 427 cardiac muscle, action on, 426 circulation, action on, 427 emetic, action on, 180 604 INDEX VERATRINE, local action, 427 muscles, action on, 425-427 nerves, passage along, 425 VERATRUM (see Veratrine) VERONAL, 97 VESICANTS, 489 ff. VESSELS (see under Circulation) WATER, absorption of, 386 diuretic action of, 354 lack of, metabolic effects, 387 local action, 385, 386 metabolism, action on, 386, 387 pharmacological actions of, 385-387 XEROFORM, 520 X-RAYS, leucocytes, action on, 447 metabolism, action on, 383 ovaries, effect on, 218 testicles, effect on, 218 YEW TREE (see Thuja occidentalis) YOHIMBIN, aphrodisiac action, 219 vessels, elective action on certain, 289 in vascular diseases, 331 ZINC SALTS, in inflammation, 494 ZINC SULPHATE, emetic action of, 183. 