Supplementary Figure S4 from Blocking Tumor Necrosis Factor α Enhances CD8 T-cell–Dependent Immunity in Experimental Melanoma
Days!
**!**!**! **!
**!
WT!
TNF KO!
Tumor volume (mm3)!
MHC-I!
Cell (%)!
B!
0 
50 
100 
150 
200 
250 
300 
5 
10 
15 
20 
25 
**!
MHC-I!
Cell (%)!
8!
10!
12!
14!
16!
0!
200!
400!
600!
800!
1000!
1200!
WT!
TNF KO!
Days!
A!
Tumor volume (mm3)!
6!
Yumm melanoma!
B16-BL6 melanoma! Days! **!**!**! **! **! WT! TNF KO! Tumor volume (mm3)! MHC-I! Cell (%)! B! 0 
50 
100 
150 
200 
250 
300 
5 
10 
15 
20 
25 
**! MHC-I! Cell (%)! 8! 10! 12! 14! 16! 0! 200! 400! 600! 800! 1000! 1200! WT! TNF KO! Days! A! Tumor volume (mm3)! 6! Yumm melanoma! B16-BL6 melanoma! MHC-I! Cell (%)! 8
10
12
14
16
0! 200! 400! 600! 800! 1000! 1200! WT! TNF KO! A! Tumor volume (mm3)! 6! B16-BL6 melanoma! 8! 10! 12! 14! 16! 0! 200! 400! 600! 800! 1000! 1200! WT! TNF KO! Tumor volume (mm3)! 6! A! B16-BL6 melanoma! Figure	
  S2	
  
Days! **!**!**! **! **! WT! TNF KO! Tumor volume (mm3)! MHC-I! Cell (%)! B! 0 
50 
100 
150 
200 
250 
300 
5 
10 
15 
20 
25 
**! MHC-I! Cell (%)! 8! 10! 12! 14! 16! 0! 200! 400! 600! 800! 1000! WT! TNF KO! Days! Tumor volume (m
6! Yumm melanoma! Days! **!**!**! **! **! WT! TNF KO! Tumor volume (mm3)! MHC-I! Cell (%)! B! 0 
50 
100 
150 
200 
250 
300 
5 
10 
15 
20 
25 
**! Days! Yumm melanoma! B! Figure	
  S2 Figure	
  S2