Django project is creating into C:\VTRoot\HarddiskVolume3 by default
I am running on a PC that has Comodo managed by devops. I cannot control the settings without them being approved and implemented by someone else. But there is probably a folder where you can do this work if you are able to move to it.
For me, it was C:\ProgramData\Shared Space
This is a hidden directory. Use at your own risk!
Summary: Comodo -> Settings -> Containment -> (Do not virtualize access to) the Specified files folders -> Expand Shared Spaces and see where it points.
Details:
In Comodo, if you open up the program from the taskbar, and then click on settings. You will see tabs on the left. Click on the one labeled "Containment."
Hopefully a "Shared Space" has been made available for you to put this sort of work in that will not be virtualized / quarantined. 
Locate "Do not virtualize access to the specified files/folders" Click on the link in that sentence.
A dialog will open up that shows the shared spaces that have been defined. Expand that list and you will see where you can put files / folders that Comodo will ignore.
I am putting "django-admin startproject mysite". Project is creating in the folder of C:\VTRoot\HarddiskVolume3 by default instate of desire folder. Please help me out.
pip install django