Using Django's Model API without having to *include* the full Django stack
You may be able to get a good idea of what is safe to strip out by checking which files don't have their access time updated when you run your application.
Currently an application of mine is using SQLAlchemy, but I have been considering the possibility of using Django model API. 
Django 1.1.1 is about 3.6 megabytes in size, whereas SQLAlchemy is about 400 kilobytes (as reported by PyPM - which is essentially the size of the files installed by python setup.py install).
I would like to use the Django models (so as to not have other developers learn yet-another-ORM), but do not want to include 3.6 megabytes of stuff most of which are not needed. (FYI - the application, final executable that is, actually bundles the install_requires from setup.py)