Reverse Engineer a .pyo python file
Convert the .pyo files to .py and then edit the .py and then run python on the .py files. Python will regenerate the .pyo files Don't edit the pyo
I don't know the python bytecode but I would doubt that the strings == or 1= would appear in the .pyo file 
Although a much better way is get the original .py files and use them. If they give the wrong program as implied by wanting to change != to == then you could ask the supplier to fix the bug.
I have 2 .pyo python files that I can convert to .py source files, but they don't compile perfectly as hinted by decompyle's verify.
Therefore looking at the source code, I can tell that config.pyo  simply had variables in in an array:
ADMIN_USERIDS = [116901,
 141,
 349244,
 39,
 1159488]
I would like to take the original .pyo and disassembly or whatever I need to do inorder to change one of these IDs.
Or....
in model.pyo the source indicates a 
if (productsDeveloperId != self.getUserId()):
All I would want to do is hex edit the != to be a == .....Simple with a windows exe program but I can't find a good python disassembler anywhere.
Any suggestions are welcomed...I am new to reading bytecode and new to python as well.