Do I need to use a web framework for a simple website?
As RonakG first pointed, it all depends on the kind of website you intend to have up and running. Actually, your question is too general for a single, definitive answer. There are more aspects to consider other than just being in python. For example, deadlines. This means considering the learning curve to achieve your results. If you don't have much time, a steep learning curve (time to learn it in order to develop it) is certainly something you will want to avoid. Perhaps you already develop in other languages, and need integration and/or migration support, need scalability, reusability, etc, etc, etc.
Another thing that is not so clear in your question is what you mean by "The site won't be that complicated and will resemble a modern blog (users, messages, news and other similar features)". If it really resembles just a modern blog, with users, messages and news, you could google for CMS (Content Management Systems). There are many options available, that could make you have your site up and running in almost no-time. All you'll have to learn is how to customize whatever it has to as to comply to your needs.
That said, if you prefer python, there are some good CMSs available which you can develop your site fast, like Plone. And if you prefer Django, there's Django CMS and there's the excellent Pinax project, which takes the django code reusability to deliver you sample fully customizable, complete websites.
The site won't be that complicated and will resemble a modern blog (users, messages, news and other similar features).
Do I need to use a framework for this, and if so, which is best?
Pyramid, Django?