Does using Psyco with django make any sense?
You should be using fastcgi or wsgi with django, so the process won't be starting up for each request.
You really need to write your code to be psyco friendly if you want decent gains, and you will not benefit if your bottleneck is the database.
I know the benefits of Psyco for a Desktop app, but in a Web app where a process ( = a web page or an AJAX call) dies immediately after been fired, isn't it pointless ?