Starting a new database driven python web application would you use a javascript widget framework? If so which framework?
web2py uses jQuery
I am starting a new web application project. I want to use python as I am using it at my bread-and-butter-job.
However I don't want to reinvent the wheel. Some things I have thought about:

AJAX would be nice if it’s not too much of a hazzle. 
It is best if the licensing allows commercialization but is not crucial at this point.
It could also be funny to try out the Google App Engine if the tools will let me.

Should I be using a javascript UI framework or should I go for standard HTML forms? 
Which framework would you recommend?