Django sqlite database is locked
I have had a lot of these problems with Sqlite before. Basically, don't have multiple threads that could, potentially, write to the db. If you this is not acceptable, you should switch to Postgres or something else that is better at concurrency.
Sqlite has a very simple implementation that relies on the file system for locking. Most file systems are not built for low-latency operations like this. This is especially true for network-mounted filesystems and the virtual filesystems used by some VPS solutions (that last one got me BTW).
Additionally, you also have the Django layer on top of all this, adding complexity. You don't know when Django releases connections (although I am pretty sure someone here can give that answer in detail :) ). But again, if you have multiple concurrent writers, you need a database layer than can do concurrency. Period.
I solved this issue by switching to postgres. Django makes this very simple for you, even migrating the data is a no-brainer with very little downtime.
I've been struggling with "sqlite3.OperationalError database is locked" all day....  
Searching around for answers to what seems to be a well known problem I've found that it is explained most of the time by the fact that sqlite does not work very nice in multithreading where a thread could potentially timeout waiting for more than 5 (default timeout) seconds to write into the db because another thread has the db lock .
So having more threads that play with the db , one of them using transactions and frequently writing I've began measuring the time it takes for transactionns to complete. I've found that no transaction takes more than 300 ms , thus rendering as not plausible the above explication. Unless the thread that uses transactions makes ~21 (5000 ms / 300 ms) consecutive transactions while any  other thread desiring to write gets ignored all this time
So what other hypothesis could potentially explain this behavior ?