Is there any python web app framework that provides database abstraction layer for SQL and NoSQL?
Regarding App Engine, all existing attempts limit you in some way (web2py doesn't support transactions or namespaces and probably many other stuff, for example). If you plan to work with GAE, use what GAE provides and forget looking for a SQL-NoSQL holy grail. Existing solutions are inevitably limited and affect performance negatively.
Is it even possible to create an abstraction layer that can accommodate relational and non-relational databases? The purpose of this layer is to minimize repetition and allows a web application to use any kind of database by just changing/modifying the code in one place (ie, the abstraction layer). The part that sits on top of the abstraction layer must not need to worry whether the underlying database is relational (SQL) or non-relational (NoSQL) or whatever new kind of database that may come out later in the future.