Django Sessions
The filesystem backend is only worth looking at if you're not going to use a database for any other part of your system. If you are using a database then the filesystem backend has nothing to recommend it.
The memcache backend is much quicker than the database backend, but you run the risk of a session being purged and some of your session data being lost.
If you're a really, really high traffic website and code carefully so you can cope with losing a session then use memcache. If you're not using a database use the file system cache, but the default database backend is the best, safest and simplest option in almost all cases.
I'm looking at sessions in Django, and by default they are stored in the database.  What are the benefits of filesystem and cache sessions and when should I use them?