Which python project to choose for a database-heavy application
Imo the only part of django that might be "too" publishing orientated is the admin, but I have seen plenty of django applications doing stuff neatly. 
Django has plenty of apps available covering what you want to do, but the only road block you might find is the part of: handle lots of data and complex queries. You will probably move out of django ORM land, but you might even move out of SQLAlchemy land too. Most of these projects use ORM's, so I would look into SQLAlchemy first, and evaluate how to use it for your needs.
Second, I would just go through the tutorials of the following projects, reading about them is good, but a small little tutorial/project (or mini prototype) is the only way to see if the project fits your programming style: pyramid, turbogears, and django. They have afaik the largest communities. The best tool will be the one you feel more confortable with. They all have good, excellent documentation, good supportive communities, and are mature enough for solid projects, and for very subtle differences, you probably can use any of them for your needs.
I plan to develop a rather database heavy (~100 tables) web application in python. The focus is on providing a nice and task-optimized interface for people that edit or navigate through the data. Other focuses are:

Handle lots of data and complex queries.
Internationalization (translation, timezones, currencies)
Mailings (bulk emailing as well as notifications)
Easy integration into other websites (pull data from or push data to the application)
A role based authentication scheme. (ideally enforcing one role at a time)
It should be easy and fast (for python programmers) to create custom forms and workflows to work with the data.

I've read a lot about django, turbogears, pyramid, webcore, … but I'm still having a hard time to figure out where to start.
My current evaluation would suggest that turbogears is the way to go. Pyramid seems too much to learn about. Django seems to be too publishing focused. WebCore seems a bit to immature to base such a project on it.
Am I overlooking something? Are there other more suitable python frameworks? Is my information about some of them plain wrong? Which framework would you choose for this project, and why?