I have a box where we are running a internal web page build on perl-cgi. My knowledge is little limited about coding. but I want to run some pages built on python cgi. Technically is it possible to run both perl+python cgi on same server without doing much configuration change
Yes. It's actually very easy. Because cgi doesn't care what language it's written it - it's just a script that the web server runs on demand, and passes parameters. 
You can even use compiled C as your cgi language if you want. 
All you need to do is be able to read the local environment (and pretty much every language can) and read STDIN - and pretty much every language can. 
You can comfortably run perl and python scripts along side each other - the server simply doesn't care. 
To get more complicated, you might want to preload/prefork your cgi scripts, and then it starts to be a little more complicated to use arbitrary languages. 
But for a basic run-on-demand cgi script, anything will suffice.
Can we run perl and python cgi web portal from same server/box