I have a python (well, it's php now but we're rewriting) function that takes some parameters (A and B) and compute some results (finds best path from A to B in a graph, graph is read-only), in typical scenario one call takes 0.1s to 0.9s to complete. This function is accessed by users as a simple REST web-service (GET bestpath.php?from=A&to=B). Current implementation is quite stupid - it's a simple php script+apache+mod_php+APC, every requests needs to load all the data (over 12MB in php arrays), create all structures, compute a path and exit. I want to change it. 
I want a setup with N independent workers (X per server with Y servers), each worker is a python app running in a loop (getting request -> processing -> sending reply -> getting req...), each worker can process one request at a time. I need something that will act as a frontend: get requests from users, manage queue of requests (with configurable timeout) and feed my workers with one request at a time. 
how to approach this? can you propose some setup? nginx + fcgi or wsgi or something else? haproxy? as you can see i'am a newbie in python, reverse-proxy, etc. i just need a starting point about architecture (and data flow)
btw. workers are using read-only data so there is no need to maintain locking and communication between them
Another option is a queue table in the database.
The worker processes run in a loop or off cron and poll the queue table for new jobs.
how to process long-running requests in python workers?