If yes are there any frameworks/Tutorials/tips/etc recommended? 
N00b at Python but I have tons of PHP experience and wanted to expand my skill set.
I know Python is great at server side execution, just wanted to know about client side as well.
On Windows, any language that registers for the Windows Scripting Host can run in IE. At least the ActiveState version of Python could do that; I seem to recall that has been superseded by a more official version these days.
But that solution requires the user to install a python interpreter and run some script or .reg file to put the correct "magic" into the registry for the hooks to work.
Can Python be used for client side web development?