I have a friend who likes to use metaclasses, and regularly offers them as a solution.
I am of the mind that you almost never need to use metaclasses. Why? because I figure if you are doing something like that to a class, you should probably be doing it to an object. And a small redesign/refactor is in order.
Being able to use metaclasses has caused a lot of people in a lot of places to use classes as some kind of second rate object, which just seems disastrous to me. Is programming to be replaced by meta-programming? The addition of class decorators has unfortunately made it even more acceptable.
So please, I am desperate to know your valid (concrete) use-cases for metaclasses in Python. Or to be enlightened as to why mutating classes is better than mutating objects, sometimes.
I will start:

Sometimes when using a third-party
  library it is useful to be able to
  mutate the class in a certain way.

(This is the only case I can think of, and it's not concrete)
The only legitimate use-case of a metaclass is to keep other nosy developers from touching your code. Once a nosy developer masters metaclasses and starts poking around with yours, throw in another level or two to keep them out. If that doesn't work, start using type.__new__ or perhaps some scheme using a recursive metaclass.
(written tongue in cheek, but I've seen this kind of obfuscation done. Django is a perfect example)
What are some (concrete) use-cases for metaclasses?