I would be interested to learn about large scale development in Python and especially in how do you maintain a large code base?

When you make incompatibility changes to the signature of a method, how do you find all the places where that method is being called. In C++/Java the compiler will find it for you, how do you do it in Python?
When you make changes deep inside the code, how do you find out what operations an instance provides, since you don't have a static type to lookup?
How do you handle/prevent typing errors (typos)?
Are UnitTest's used as a substitute for static type checking?

As you can guess I almost only worked with statically typed languages (C++/Java), but I would like to try my hands on Python for larger programs. But I had a very bad experience, a long time ago, with the clipper (dBase) language, which was also dynamically typed.
My general rule of thumb is to use dynamic languages for small non-mission-critical projects and statically-typed languages for big projects. I find that code written in a dynamic language such as python gets "tangled" more quickly. Partly that is because it is much quicker to write code in a dynamic language and that leads to shortcuts and worse design, at least in my case. Partly it's because I have IntelliJ for quick and easy refactoring when I use Java, which I don't have for python.
How can I use Python for large scale development?