I was wondering if there was a way that you could get init code to run upon importing a .NET assembly using clr.AddReference(), in the same way that importing a python file executes the init.py code that resides in the same directory.  Thanks in advance!
It is not possible.
The only way is to change the clr.AddReference method. As IronPython is open source it should be easy.
IronPython: how can I run init code when I import a module using clr.AddReference()?