I'm lucky enough to have full control over the architecture of my company's app, and I've decided to scrap our prototype written in Ruby/Rails and start afresh in Python. This is for a few reasons: I want to learn Python, I prefer the syntax and I've basically said "F**k it, let's do it."
So, baring in mind this is going to be a pretty intensive app, I'd like to hear your opinions on the following:

Generic web frameworks
ORM/Database Layer (perhaps to work with MongoDB)
RESTful API w/ oAuth/xAuth authentication
Testing/BDD support
Message queue (I'd like to keep this in Python if possible)

The API is going to need to interface with a Clojure app to handle some internal data stuff, and interface with the message queue, so if it's not Python it'd be great to have some libraries to it.
TDD/BDD is very important to me, so the more tested, the better!
It'll be really interesting to read your thoughts on this. Much appreciated.
My best,
Jamie
I'm new to python myself, and plan to get more in depth with it this year. I've had a few false starts at this, but always professional needs bring me back to PHP. The few times I've done some development, I've had really good experiences with web2py as a python framework. It's quite well done, and complete in features, while still being extremely lightweight. The database layer seems to be very flexible and mature. 
As for TDD/BDD and the rest of your questions, I don't have any experience with python options, but would be interested to hear what others say.
Architecting from scratch in Python: what to use?