I know Ctrl + F9 runs a single file.
How to run them all?
If there is no such thing, how to bind one keyboard shortcut to it?
Go to the preferences and type in keys to get to the keyboard shortcut definition page (I think it's called keys... sorry not on my dev machine right now).  In this dialog you can search for commands.  See if there is a run all tests command (it might help to find the run tests you are currently using first).  If there is check out the shortcut or define your own.
What is the keyboard shortcut to run all unit tests in the current project in PyDev + Eclipse?