I downloaded the Wikipedia article titles file which contains the name of every Wikipedia article. I need to search for all the article titles that may be a possible match.  For example, I might have the word "hockey", but the Wikipedia article for hockey that I would want is "Ice_hockey".  It should be a case-insensitive search too.
I'm using Python, and is there a more efficient way than to just do a line by line search?  I'll be performing this search like 500 or a 1000 times per minute ideally.  If line by line is my only option, are there some optimizations I can do within this?
I think there are several million lines in the file.
Any ideas?
Thanks.
Greg's answer is good if you want to match on individual words.  If you want to match on substrings you'll need something a bit more complicated, like a suffix tree (http://en.wikipedia.org/wiki/Suffix_tree).  Once constructed, a suffix tree can efficiently answer queries for arbitrary substrings, so in your example it could match "Ice_Hockey" when someone searched for "hock".
most efficient way to find partial string matches in large file of strings (python)