I have Django app that presents a list of items that you can add comments to. 
What i basically want to do is something like the Facebook did: when someone post a comment on your item, you will receive an e-mail. What I want to do, is when you reply to that e-mail, the reply to be posted as a comment reply on the website. 
What should I use to achieve this using python as much as possible ? Maybe even Django ?
I think a good way is how Google+ handles it using a + on email address it can be reply+id-or hash-of-parent@domain.com then u must write a worker that check the POP server and
How to post a comment on e-mail reply?