The scenario is
I have multiple local computers running a python application. These are on separate networks waiting for data to be sent to them from a web server. These computers are on networks without a static IP and generally behind firewall and proxy.
On the other hand I have web server which gets updates from the user through a form and send the update to the correct local computer.
Question
What options do I have to enable this. Currently I am sending csv files over ftp to achieve this but this is not real time. 
The application is built on python and using django for the web part.
Appreciate your help
Sounds like you need a message queue.
You would run a separate broker server which is sent tasks by your web app. This could be on the same machine. On your two local machines you would run queue workers which connect to the broker to receive tasks (so no inbound connection required), then notify the broker in real time when they are complete. 
Examples are RabbitMQ and Oracle Tuxedo. What you choose will depend on your platform & software.
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