I am working on tiny program to capture screen print, I want to do it in a similar fashion that Win Snipping Tool is working. First I need to overlay all screens with a 50% opacity layer and then, using the mouse, draw a rectangle and read vertices coordinates. Honestly, I have no idea how to bite this. I tried with win32api / gui and it is great to get mouse coordinates, but still was unable to draw a rectangle. My idea (one of many) is to (using PIL / ImageGrab) take shots of both displays, put an overlay and print them as a full screen on all windows, but I failed while doing this. Other idea is to take img grab and create two new windows using BeeWare / Toga (that is GUI framework I am using) in full screen, but I was unable to find any method to open window on second display. Any ideas and hints will be greatly appreciated, I am really counting on you, as I feel I reached dead end.
Well,It is very easy to use tkinter.
Ok,It is the principle when I make my screenshot application:

User presses the button to start.
Make a new window whose width and height should full cover all the screens,and hide the title bar(If it is had to achieve,maybe use width=9999 and height=9999).
Take a screenshot of all the desktop(You can use ImageGrab.grab((),all_screens=True)) to do that.
Make the screenshot showed in a Canvas(I know that toga have this widget).
Start your mouse listener thread and save the position of pressed.
When user moves his mouse,create a rectangle(toga's Canvas have a function rect()).Maybe use this rect(pressed_x,pressed_y,move_x,move_y).And delete the last rectangle(Then it will always show only one rectangle).
When user released his mouse,save the position of released.And use ImageGrab.grab((pressed_x,pressed_y,released_x,released_y),all_screens=True) to crop the selected area.
If you want to show it in application interface.toga has a widget called ImageView.You can put the image in it.
Overlay all screens and draw rectangle with a mouse