I have the latest version of Python 3 and PyAutoGUI module on Windows 7 x64. Hotkeys like ALT + F4, CTRL + SHIFT + ESC works pretty well, but, from what I noticed, doesn't works CTRL + C and CTRL + V at all!
choose "EN" default keyboard layout in your OS
Doesn't works CTRL+V in PyAutoGUI, Python 3 on Windows