I've never created a GUI before, just simple text based stuff.  I think I'm ready to move on to building a GUI and I have a project in mind.  Specifically, I'm thinking about creating a simple touch typing tutor game...nothing too fancy.  Which python GUI toolkit and builder would lend itself best to a project like this?
You can use Pygame modul
Pygame site has a lot of tutorials, you can use those tutorials as a starting point.
Good Luck!
python GUI to build a simple typing tutor game