I need to create a desktop app that will work with Windows and Gnome(Ubuntu).  I would like to use Python to do this.  The GUI part of the app will be a single form with a message area and a couple of buttons.
The list of GUI's for Python seems overwhelming.  I am looking for something simple if possible, the main requirements is it must work with Gnome(2.26 and up) and Windows XP/Vista/7.
You might want to check out wxPython. It's a mature project and should work on Windows
and Linux (Gnome).
Python GUI Library for Windows/Gnome