I've been toying with wxPython, but it seems mostly geared at 'standard' applications -- things with native looking file menu systems and toolbars and whatnot. 
My needs are pretty simple. I just need to be able play some mp3s, show some images, and be able to package it down to an .exe and .dmg. Also, being able to play an small mp4 would be grand. 
Unfortunately, I realize that there is no definitive answer to this question, and therefore doesn't exacltly fit the stack overflow format, but a nudge in the right direction would be greatly appreciated!
Pyqt/pyside/Qt has the newer declarative QML which seems to have a application geared to a kiosk type interface. You can basically design something in Photoshop and use it as your custom UI
Is there a preferred framework for non-standard, non-native kiosk style GUI applications?