Has anyone done this?  I've tried generating a c# proxy class and connecting through it, but I cannot figure out how to get IronPython to use the generated app.config file that defines the endpoint.  It tries to connect, but I just get an error about no default endpoint.  I would ideally like to make the connection using only IronPython code and not use the proxy class, if possible.  The binding for the service I am trying to connect to is a NetTcpBinding if that makes any difference.
Is your WCF service interface available in a shared assembly?  If so, you could look at using the ChannelFactory to create your client proxy dynamically (instead of using the generated C# proxy).  With that method you can supply all the details of the endpoint when you create the ChannelFactory and you won't require any configuration in your .config file.
How to connect to a WCF Service with IronPython