I've gone from one book to another, one google search to another and I notice EVERY SINGLE ONE starts the main window in a completely different way.
I don't want to pick up bad habits so can someone please give me the best of these options and why its the better method. Below are all the ways i've seen it done
A)
class iFrame(wx.Frame):
    def init(....):
        wx.Frame._init_(...)
B)
class iFrame(wx.Frame):
    def init(...):
        super_init_(...)
C)
Then I see some that uses the Panel instead such as
class iPanel(wx.Panel)
    def init(...):
        wx.Panel.init(...)
D)
And even more confusing some are using the regular App class of wx
class iApp(wx.App):
    def OnInit(self):
        wx.Frame.init(...)
Forgive me if some of my structures are wrong but I'm recalling these off the top of my head, Question again...Which one of these, IF ANY is the best way to structure the GUI. It's hard following tutorials and books when they all do things in diff ways
edit: Sorry if format is not correct, but normally it works...
Don't worry about it. You aren't going to ruin your future programming by making the wrong choice now. 
None of the options you mention are wrong. They all do things differently because different applications have different requirements. No one way is best.
Just work on what you want and do what works for you, and once you have greater familiarity then you'll understand why different code does it differently.
Confused on how to structure the GUI (wxpython)