Following is the configuration:
1.Python - Python 3.8.1 (tags/v3.8.1:1b293b6, Dec 18 2019, 23:11:46) [MSC v.1916 64 bit (AMD64)] on win32
2.MS Access 2016 MSO(16.0.12624.20348) 64 bit
3.Microsoft Access Driver (*.mdb, *.accdb) 16.00.4513.1000
4.Installed Microsoft Access Database Engine 2016 Redistributable
Facing the error while trying to create a connection:
import pyodbc
conn = pyodbc.connect(r'Driver={Microsoft Access Driver (*.mdb, *.accdb)};DBQ=C:\Users\tejas\Documents\First.accdb;')
cursor = conn.cursor()
Error:
Traceback (most recent call last):
  File "C:\Users\tejas\eclipse-workspace\HelloWorld\DB\Insert.py", line 3, in 
    conn = pyodbc.connect(r'Driver={Microsoft Access Driver (*.mdb, *.accdb)};DBQ=C:\Users\tejas\Documents\First.accdb;')
pyodbc.Error: ('HY000', '[HY000] [Microsoft][ODBC Microsoft Access Driver] The database you are trying to open requires a newer version of Microsoft Access. (-1073) (SQLDriverConnect); [HY000] [Microsoft][ODBC Microsoft Access Driver] The database you are trying to open requires a newer version of Microsoft Access. (-1073)')
I have gone through other similar questions and tried various options but no luck so far. Any help would be appreciated.
I found this because I added a table to a MS Access database and set one of the fields to "Large Number".  This broke my connection with pyodbc, and consequently my python scripts which write to this database.  I had no way to revert the file.
I fixed it by creating a new database and importing all the old tables that didn't have any Large Number fields.  I then was able to simply copy and paste the queries and forms over to the new database file.  It seems to work fine now with the new file.  I've learned by lesson and won't be assigning "large number" to anything soon in MS Access.
Thanks!
Connect Python to Access 2016: "database ... requires a newer version of Microsoft Access"