I create many records in my DB as follows:
Subproducts.create(mf_id=mf_id,
                     co=co,
                     mf_binary=mf_binary_data.getbuffer())
mf_binary type is io.BytesIO() - it is binary representation of binary files collected into zipfile
I've successfully created many records using this approach, however I have an issue with one particular dataset. 
It is a bigger than other and it takes ~1,2GB. 
When I try to save it in DB following error occurs.
peewee.InterfaceError: Error binding parameter 2 - probably unsupported type.
Field of mf_binary in my model is peewee.BlobField(default=b'0')
How can I store this kind of data in peewee Database?
Calling getbuffer() returns a memoryview object which is apparently not supported by the underlying database driver (which one is it, by the way?). The InterfaceError is raised by your database driver as opposed to Peewee, which indicates the problem comes from your driver not understanding how to handle memoryview objects.
Your best bet is to use mf_binary_data.getvalue(), which should return a bytes object.
peewee.InterfaceError: Error binding parameter while saving big amout of data