Sure! Here is an example of a screenplay with only one character:

INT. BEDROOM - DAY

A man, JOE, sits on his bed, staring at the wall in front of him. He looks defeated, lost in thought.

JOE (V.O.)
I can’t believe it’s come to this. How did I get here?

Joe stands up, pacing back and forth. He rubs his temples, trying to think.

JOE (V.O.)
I used to have everything. A good job, a beautiful wife, a great life. But now, I’ve lost it all.

Joe walks over to a nearby dresser and opens a drawer, pulling out a bottle of whiskey. He unscrews the cap and takes a swig, closing his eyes as the alcohol burns down his throat.

JOE (V.O.)
Maybe this will numb the pain. Maybe this will make it all go away.

Joe takes another swig, then another. He continues to drink, lost in his thoughts, until he finally passes out on the bed.

FADE TO BLACK.

THE END.
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