The concept of clones in algebra was first introduced by the Hungarian mathematician, Alfréd Rényi, in the 1950s. Rényi's work on clones built upon earlier work by the Polish mathematician, Kazimierz Kuratowski, on abstract algebraic systems.

The study of clones and their properties has since become an important area of research in algebra and universal algebra, with many significant results and applications in areas such as logic, automata theory, and computer science.

In addition to Rényi and Kuratowski, other notable mathematicians who have contributed to the development of the theory of clones include C.C. Chang, H. Jerome Keisler, Ross Willard, and Ralph McKenzie.
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