Here is a simple python script that clicks on the centre of the screen using the pyautogui library.

'''
import pyautogui

# Get the screen size
screen_width, screen_height = pyautogui.size()

# Calculate the center of the screen
center_x = screen_width / 2
center_y = screen_height / 2

# Click in the center of the screen
pyautogui.click(center_x, center_y)
''''
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