Here's a PyAutoGUI script to click in the center of the screen:

'''python
import pyautogui

# Get the screen resolution
screen_width, screen_height = pyautogui.size()

# Calculate the center of the screen
center_x, center_y = screen_width / 2, screen_height / 2

# Perform a mouse click at the center of the screen
pyautogui.click(center_x, center_y)
'''
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