Generally, it seems that Neo layout may be what you are looking for.
Here are some keyboard layouts for various use cases: 
For French: BvoFrak, Bépo
For German: Neo, AdNW
For English: DHIATENSOR, Dvorak,
For programing: Programmer Dvorak, Evolved, Capewell, QGMLWY, Arensito
Note that while layout may contribute to wrist pain, other factors like the angle of the keyboard, key spacing (vertical, horizontal, and depth), more may also be contributing factors. Learning a new layout takes time and effort, and may make it more difficult to type on other keyboards.
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