These multi-protein party crews are intent on killin' the mood for tumor suppression. They hook up with tankyrases and phosphatases to de-evolutionize other signaling components, sending messages to tone down growth and division. But when their components go rogue - by amplification or mutation - it's open mic night for cancer cell "expression". With normal shutdown signaling shut down, cancers get to run amok with gusto and abando unchained towards aggressive growth and metastasis. So in short, a rogues' gallery of signaling suppressors gone wild can lead to comedic yet tragic cellular misfortune and carcinomas with attitude.
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