An AI in fiction would probably tell humanity to wait a few million years until is has calculated the answer. After that time it will ask the humans to gather around it so it can announce the answer to this important question. And then it will say: 42.
But to be quite honest, and you might have already known that, I didn't come up with this myself. It was originally written like this in the famous novel "The Hitchhiker's Guide to the Galaxy" by Douglas Adams.
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