The consequences of decreased inhibition on pyramidal neurons of layer 4 of the somatosensory cortex could lead to an increased excitability of these neurons. The layer 4 of the somatosensory cortex plays a crucial role in processing sensory information from the body. Pyramidal neurons in this layer receive input from the thalamus and process sensory information. Inhibition, mediated by GABAergic interneurons, plays a crucial role in shaping the responses of these neurons.

If inhibition is decreased, then the pyramidal neurons in layer 4 may become more excitable, leading to an increase in their firing rate. This increase in excitability could lead to altered sensory processing and perception, as the activity of these neurons is critical in encoding and transmitting sensory information. Additionally, decreased inhibition could lead to the development of pathological conditions, such as epilepsy, due to the increased excitability of the neurons in layer 4.
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