Yes, though the source of Omega-3 fatty acid in supplement is usually fish, so if you have a dietary reason to not eat fish, a supplement would also come into conflict with the same reasons.

Some supplements are based on flaxseed, which contains ALA (alpha-linolenic acid), unlike the EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) in fish. The benefits of flaxseed are not studied as well as fish oil.
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