Trilobites, as marine arthropods, faced various predators during their time, which spanned from the Early Cambrian to the end of the Permian period. Some of the main predators of trilobites included:

1. Anomalocaridids: These were large, carnivorous marine arthropods that lived during the Cambrian period. Anomalocaridids had large, grasping appendages and a circular mouth with sharp plates, which they likely used to catch and eat trilobites.

2. Cephalopods: Early cephalopods, such as nautiloids and ammonoids, may have preyed on trilobites. These ancient relatives of modern-day squid and octopuses had hard, beak-like mouths that could crack open the trilobite's exoskeleton.

3. Eurypterids (sea scorpions): These were large marine arthropods that lived during the Paleozoic era. Some eurypterids were active predators, and it is likely that they preyed on trilobites.

4. Other trilobites: Some trilobite species were carnivorous and likely preyed on smaller or weaker members of their own kind.

Regarding genetic descendants, trilobites went extinct around 252 million years ago at the end of the Permian period. There are no direct descendants of trilobites alive today. However, trilobites belong to the phylum Arthropoda, which is a large and diverse group that includes insects, crustaceans, chelicerates (e.g., spiders and scorpions), and myriapods (e.g., centipedes and millipedes). While these living arthropods are not direct descendants of trilobites, they share a distant common ancestor and are considered genetic "cousins" to the extinct trilobites.
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