A novel polypeptide, designated neurotrophic factor-4 (NT-4), has been ident-ified by PCR amplification of human genomic DNA. Pro-vided herein is nucleic acid encoding NT-4 useful in diag-nostics and in the recombi-nant preparation of NT-4. A1-- so provided herein are nucleic acids encoding naturally oc-curring amino acid sequence variants of NT-4, designated NT-4.beta., NT-4.gamma., and NT-4.DELTA.. The neurotrophic factors of the invention are useful in the treatment of nerve cells and in diagnostic assays.
NT-4 NEUROTROPHIC FACTOR