PCT No. PCT/JP94/02132 Sec. 371 Date Jun. 25, 1996 Sec. 102(e) Date Jun. 25, 1996 PCT Filed Dec. 19, 1994 PCT Pub. No. WO95/18110 PCT Pub. Date Jul. 6, 1995A benzodiazepine derivative of the formula (I): <IMAGE> (I) wherein R1 is a bond, -CH2-, -CH2O-, -SCH2- or a group of the formula: <IMAGE> R2 is a lower alkyl, -COOR5, -CONH(CH2)nCOOR5, -CONHSO2R5, -SO2NHCOR5, or an optionally substituted heterocyclic group (R5 is a hydrogen atom, lower alkyl or benzyl and n is an integer of 1 to 5); R3 is a bond, -CO- or -CONH-; and R4 is an optionally substituted heterocyclic group, optionally substituted lower alkyl, optionally substituted lower cycloalkyl, optionally substituted aryl, or lower alkoxycarbonyl group, or a pharmaceutically acceptable salt thereof, which has a high affinity for gastrin receptors and/or CCK-B receptors but not for CCK-A receptors, and is useful for treating diseases associated with gastrin receptors and/or CCK-B receptors without inducing the side effects associated with CCK-A receptors.
Benzodiazepine derivative