<P>PROBLEM TO BE SOLVED: To provide humanized recombinant anti-VLA-4 antibody molecules useful in the treatment of specific and non-specific inflammation, including asthma and inflammatory bowel disease and, in addition, useful in methods of diagnosing and localizing sites of inflammation. <P>SOLUTION: The humanized recombinant anti-VLA-4 antibody molecules having specificity to VLA-4 and an antigen-binding site, wherein at least one of the complementarity determining regions (CDRs) of variable regions is derived from non-humanized recombinant anti-VLA-4 antibody, and the antibody has an efficacy of about 20 to 100% based on the potency of mouse HP1/2 monoclonal antibody. <P>COPYRIGHT: (C)2007,JPO&INPIT 
RECOMBINANT ANTI-VLA-4 ANTIBODY MOLECULE