INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIP0 I PCT omit VIII °nolo O II oimIE (10) International Publication Number WO 2018/167151 Al (51) International Patent Classification: CO7K 14/705 (2006.01) A61K 38/17 (2006.01) CO7K 14/725 (2006.01) (21) International Application Number: PCT/EP2018/056399 TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: PCT/EP2017/056086 14 March 2018 (14.03.2018) English English Published: — with international search report (Art. 21(3)) 15 March 2017 (15.03.2017) EP (71) Applicants: BIONTECH CELL & GENE THERAPIES GMBH [DE/DE]; An der Goldgrube 12, 55131 Mainz (DE). TRON — TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITATSMEDIZIN DER JO- HANNES GUTENBERG-UNIVERSITAT MAINZ GEMEINNUTZIGE GMBH [DE/DE]; Freiligrathstrasse 12, 55131 Mainz (DE). UNIVERSITATSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAT MAINZ [DE/DE]; Langenbeckstrasse 1, 55131 Mainz (DE). (72) Inventors: VOSS, Ralf Holger; Lotharstrasse 32, 55218 Ingelheim (DE). SAHIN, Ugur; c/o BioNTech AG, An der Goldgrube 12, 55131 Mainz (DE). SIMON, Petra; c/o BioNTech AG, An der Goldgrube 12, 55131 Mainz (DE). BIRTEL, Matthias; Boppstrasse 1, 55118 Mainz (DE). CASPAR, Janina; Genheimerstrasse 16, 55425 Wal- dalgesheim (DE). (74) Agent: SCHNAPPAUF, Georg; ZSP Patentanwalte PartG mbB, Hansastr. 32, 80686 Miinchen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (54) Title: ANTIGEN RECEPTORS AND USES THEREOF (57) : The present invention generally embraces the treatment of diseases by targeting cells expressing an antigen on the cell surface. In particular the invention relates to recombinant antigen receptors and uses thereof. T cells engineered to express such antigen receptors are useful in the treatment of diseases characterized by expression of one or more antigens bound by the antigen receptors.
ANTIGEN RECEPTORS AND USES THEREOF