Methods for generating various cellular phenotypes from central nervous syst em stem cells are disclosed. Cellular differentiation into phenotypes of organs and tissues within and outside of the central nervous system is induced by c o- culture with target cell types or by soluble trophic factors and elements of the extracellular matrix. Established pluripotent CNS stem cell lines are al so disclosed.
GENERATION OF MULTIPOTENT CENTRAL NERVOUS SYSTEM STEM CELLS