1-Aryl-3-(4-piperidyl)-indole derivatives having general formula (I), wherein R<1> is hydrogen, halogen, alkyl, alkoxy, hydroxy, cyano, nitro, alkylthio, trifluoromethyl, trifluoromethylthio, alkylsulfonyl, amino, alkylamino or dialkylamino; R is optionally substituted phenyl or a heteroaromatic group; and R<2> is hydrogen, cycloalkyl, alkyl or alkenyl, optionally substituted with one or two hydroxy groups, or R<2> is a group of formula (IV), wherein n is an integer from 2-6; W is oxygen, sulphur or N-R<3>, wherein R<3> is H, alkyl or cycloalkyl; U is nitrogen or carbon; Z is -(CH2)m-, m being 2 or 3, or Z is -CH=CH-, 1,2-phenylene, or -COCH2- or -CSCH2-; V is oxygen, sulphur, CH2, or NR<4>, wherein R<4> is hydrogen, optionally hydroxy substituted alkyl, alkenyl or cycloalkylmethyl; are useful in the treatment of cognitive disorders in man.
TREATMENT OF COGNITIVE DISORDERS