PROBLEM TO BE SOLVED: To provide a method of delivering diagnostic agents and therapeutic agents which do not easily cross the blood brain barrier to the brain of patients in the diagnosis and treatment of lysosomal storage diseases (LSD) such as type B Niemann-Pick disease, Hurler syndrome, Gaucher disease, Fabry disease, Pompe disease and the like.SOLUTION: The method of delivering a pharmaceutical to the brain of a patient includes administering the pharmaceutical to the patient via the brain lateral ventricle at an administration speed taking more than two hours for a single dose. The pharmaceutical may be a diagnostic agent such as a contrast medium (e.g. X-ray impermeable, fluorescent, radioactive), or a therapeutic agent such as an enzyme (e.g. sphingomyelinase, alpha-L-iduronidase, glucocerebrosidase, alpha-galactosidase A, acid maltase, hexosaminidase, alpha-glucosidase) and a catheter or a pump such as an embeddable pump may be used to deliver the pharmaceutical.SELECTED DRAWING: None
SLOW INTRAVENTRICULAR DELIVERY