Neuronal excitation and inhibition of the brain is tracked in the hippocampual CAl network during a latent period, wherein biomarkers are observed which include a sustained increase in the firing rate of the excitatory postsynaptic field activity, paired with a subsequent decrease in the firing rate of the inhibitory postsynaptic field activity within the CAl region of the hippocampus; the mean amplitude profiles of both fEPSP and flPSP field potential activity during the latent period have characteristic shapes; both excitatory and inhibitory CAl field activity firing rates are observed to follow a circadian rhythm that drifts during epileptogenesis; the circadian rhythms described are in-phase in controls and anti- phase during epileptogenesis; and the fEPSP rate drifts from a circadian rhythm to a greater extent than the flPSP rate. Upon detection of one or more of the biomarkers in a patient with a predisposition to seizure, therapeutic measures including thermal, chemical, or electrical modulation are applied to prevent the occurrence of the seizure, in an open or closed loop process.
METHOD AND SYSTEM FOR DETECTING EPILEPTOGENESIS