PROBLEM TO BE SOLVED: To provide antigen binding proteins that bind to proprotein convertase subtilisin kexin type 9 (PCSK9), and methods of using and making the antigen binding proteins.SOLUTION: The invention relates to an isolated neutralizing antigen binding protein that binds to a PCSK9 protein comprising a specific amino acid sequence and decreases the LDLR lowering effect of PCSK9 on LDLR. The antigen binding protein is an LDLR non-competitive neutralizing antigen binding protein, or an LDLR competitive neutralizing antigen binding protein.SELECTED DRAWING: Figure 26
ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)