The present invention provides methods for identifying evolutionarily significant polynucleotide and polypeptide sequences in human and/or non-human primates which may be associated with a physiological condition, such as enhanced resistance to cancer and cognition, in particular related to human AATYK and 17-beta-hydroxysteroid dehydrogenase. Methods to screen for agents and methods for searching for alleles of human AATYK related to cognition are also disclosed.
METHODS TO IDENTIFY POLYNUCLEOTIDE AND POLYPEPTIDE SEQUENCES WHICH MAY BE ASSOCIATED WITH PHYSIOLOGICAL AND MEDICAL CONDITIONS