Disclosed is an isolated synthetic scaffold peptide comprising (i) SEMA-4D conformational epitope formed by the three amino acid sequences set forth in SEQ ID NO:18 (LKVPVFYALFTPQLNNV), SEQ ID NO:20 (KWTSFLKARLIASRP) and SEQ ID NO:22 (EFVFRVLIPRIARV); and (ii) a chemical linker that joins the amino acid sequences, wherein an anti-SEMA4D antibody binds the SEMA4D epitope.
Anti-sema4d antibodies and epitopes