<P>PROBLEM TO BE SOLVED: To provide effective inhibitors of neurotrophic factor biological activity. <P>SOLUTION: An isolated human trkB or trkC polypeptide includes an amino acid sequence of a polypeptide selected from the group consisting of (a) a native sequence human trkB or trkC polypeptide, (b) a polypeptide having at least 95% amino acid sequence identity with a native sequence human trkB or trkC polypeptide, exhibiting a biological property of a native human trkB or trkC polypeptide, and being non-immunogenic in the human, and (c) a fragment of the polypeptide of (a) or (b) exhibiting a biological property of a native human trkB or trkC polypeptide, and being non-immunogenic in the human. <P>COPYRIGHT: (C)2008,JPO&INPIT 
HUMAN trk RECEPTORS AND NEUROTROPHIC FACTOR INHIBITORS