The present invention relates to a new method for preparing a racemic or optically active D or L-a-glycerophosphorylcholine and a derivative thereof which have excellent therapeutic effects on both secondary symptoms caused by cerebrovascular stroke and degenerative organic brain syndromes. More specifically, the invention relates to an economical method for mass-producing the racemic or optically active D or L-a-glycerophosphorylcholine and the derivative thereof at a high purity and high yield, by performing a ring-opening reaction of racemic and optionally high purity (S) or (R)-glycidol and a derivative thereof in a room-temperature aqueous solution using choline phosphate as a starting material and using inorganic bases or Lewis acids which increase a reaction rate in the aqueous solution.
METHOD FOR PREPARING RACEMIC OR OPTICALLY ACTIVE ?-GLYCEROPHOSPHORYLCHOLINE AND DERIVATIVE THEREOF