The present invention relates to a transgenic animal model with a knock-out ZC4H2 gene, and a use thereof. Following preparation of a zebrafish with a knock-out ZC4H2 gene, it was observed that the zebrafish with a knock-out ZC4H2 gene has movement disorder symptoms, and the expression of V2a interneurons, GABAneric neurons and V2b inhibitory neurons was reduced. When the ZC4H2 gene in the zebrafish with a knock-out ZC4H2 gene was restored, it was confirmed that the expression of GABAnergic neurons was restored, and thus the zebrafish with a knock-out ZC4H2 gene of the present invention can be usefully used in a method for screening drugs associated with movement disorders including epilepsy.
TRANSGENIC ANIMAL MODEL WITH KNOCK-OUT ZC4H2 GENE, AND USE THEREOF