Disclosed is a monoclonal antibody that is an alpha v beta6 blocking antibody or an antigen binding fragment thereof that (a) specifically binds to alpha v beta6 and not other alpha v integrins or non specific integrins; (b) inhibits the binding of alpha v beta6 to latency associated peptide (LAP) with an IC50 value lower than that of antibody 10D5 and (c) binds alpha v beta6 in either cation independent manner or a cation dependent manner that does not distinguish between the use of Ca2+/Mg2+ and Mn2+ for cation-dependent binding to soluble alpha v beta6, wherein the antibody is not produced by hybridoma 6.3G9 (ATCC accession number PTA-3649) or by hybridoma 6.8G6 (ATCC accession number PTA-3645). Also disclosed are cells producing said antibodies and uses thereof.
Anti-alphavbeta6 antibodies