The present invention relates to the use of 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives according to Formula (I) the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof as selective non-peptide delta-opioid agonists for use in the prevention and/or treatment of various central nervous system disorders, in particular as selective antidepressant and anxiolytic non-peptide delta-opioid agonists. In particular are claimed compounds according to Formula (I) in which A=B is C=O or SO2, X is a covalent bond, R<1> is alkyloxy, alkyloxyalkyl, Ar or NR<9>R<10>, wherein R<9> and R<10> each independently are hydrogen or Ar ; or A=B and R<1> together form a benzoxazolyl radical ; p is zero, R<3> is benzyl optionally substituted with hydroxy, alkyl or alkyloxycarbonyl and R<4> and R<5 >each are hydrogen.
SUBSTITUTED 4-PHENYL-4-`1H-IMIDAZOL-2-YL !-PIPERIDINE DERIVATIVES AND THEIR USE AS SELECTIVE NON-PEPTIDE DELTA OPIOID AGONISTS WITH ANTIDEPRESSANT AND ANXIOLYTIC ACTIVITY