The presently disclosed subject matter provides a crystalline form of a substantially pure phosphodiesterase 4D2 (PDE4D2) polypeptide. Also provided is a crystalline form of a substantially pure phosphodiesterase 4D2 (PDE4D2) polypeptide in complex with a ligand. Also provided are methods for generating the crystalline forms of the presently disclosed subject matter and methods for identifying and designing phosphodiesterase ligands and modulators. Also provided are scalable three-dimensional configurations of points and computer readable storage media containing digitally encoded structural data.
Crystalline PDE4D2 catalytic domain complex, and methods for making and employing same