The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies e.g. E3 anti-NGF antibody comprising the heavy chain CDRs of SEQ ID NOs: 3-5 and the light chain CDRs of SEQ ID NOs: 6-8), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
USE OF ANTI-NGF ANTIBODY FOR IMPROVING STIFFNESS IN OSTEOARTHRITIS