The present invention provides a system and method for testing the neuronal effects of a compound. The system (100) includes a microelectrode array (102), a data capture unit (106) communicably coupled to the microelectrode array (102), a processor (108) communicably coupled to the data capture unit (106) and one or more input/output devices (110) communicably coupled to the processor (108). The microelectrode array (102) is capable of supporting genetically modified neuronal cells (104) and measuring neuronal activity. The method (400) determines the effects of a sample on genetically modified neuronal cells by growing a culture of genetically modified neuronal cells on a microelectrode array (402) and exposing a portion of the genetically modified neuronal cells to a sample (404). The effects of the sample on the genetically modified neuronal cells exposed to the sample are measured to determine the effects of the sample on the genetically modified neuronal cells (406).
System and method for neuronal network analysis