It is intended to provide a therapeutic or a diagnostic for tumor, in particular brain tumor, a probe for detecting/diagnosing brain tumor, a diagnostic kit for brain tumor, a method of treating tumor, in particular brain tumor, and a method of screening an anti-brain tumor agent. Among about 11,000 genes from human patients with brain tumor, 16 genes showing remarkably accelerated expression in human brain tumor compared with other non-cancer tissues are selected by Gene Chip analysis. After further narrowing down by EST screening with the use of EST database and analyzing by RT-PCR and real time quantitative PCR, it is found out that an urokinase plasminogen activator receptor-associated protein (uPARAP) is expressed specifically in tumor, in particular brain tumor. Thus, compounds such as peptides and proteins capable of specifically binding to uPARAP (for example, an antibody specifically recognizing the extracellular domain of uPARAP) are usable as therapeutics/diagnostics for brain tumor.
THERAPEUTICS/DIAGNOSTICS FOR BRAIN TUMOR