A method of evaluating the quality of a the quality of a match between two digitized images includes providing (31) a pair of digitized images I<SUB>1</SUB>(x,y,z) and I<SUB>2</SUB>(x,y,z), each image comprising a plurality of intensities corresponding to a domain of points (x,y,z) on an 3-dimensional grid, calculating (33) a motion quantification measure from said pair of images, the motion quantification measure formula (I) defined by Formula (II) wherein the sum is restricted to those I<SUB>?</SUB><0, f is a function, ß is a constant, N<SUP>-</SUP> is the number of domain points with negative subtraction image values, and wherein I<SUB>?</SUB> (x,y,z)= I<SUB>2</SUB>(x,y,z)- I<SUB>1</SUB>(x,y,z). The images depict the same object but are acquired at different times.
SYSTEM AND METHOD FOR QUANTIFYING MOTION ARTIFACTS IN PERFUSION IMAGE SEQUENCES