PROBLEM TO BE SOLVED: To obtain a method for therapy of traumatic brain impediment(TBI) or hypoxic or ischemic attack. SOLUTION: An NR2B subtype-selective N-methyl-D-aspartic acid(NMDA) receptor antagonist is administered in combination with one of (a) a sodium channel antagonist, (b) a nitrogen oxide synthase(NOS) inhibitor, (c) a glycine site antagonist, (d) a potassium channel opener, (e) an AMPA/kainic acid receptor antagonist, (f) a calcium channel antagonist, (g) a GABA-A receptor modulator (e.g. GABA-A receptor antagonist) or (i) an antiinflammatory agent to a patient requiring these therapies. The method for the therapy of the hypoxic or ischemic attack comprises administration of the NMDA receptor antagonist in combination with a thrombolytic agent to a patient requiring the therapy.
COMBINATION OF MEDICINE FOR THERAPY OF ATTACK AND TRAUMATIC BRAIN IMPEDIMENT