Disclosed is an isolated anti-GM-CSF antibody. The antibody comprises a VH region that has a CDR1 having a sequence NYYIH, a CDR2 having a sequence WINAGNGNTKYSQKFQG, and a CDR3 having a sequence RQRFPYYFDY. The antibody also comprises a VL region that has a CDR1 having a sequence RASQSVGTNVA or RASQSIGSNLA, a CDR2 having a sequence STSSRAT, and a CDR3 having a sequence QQFN(K/R)SPLT. The antibody is used in the treatment of osteopenia, rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, chronic obstructive pulmonary disease, idiopathic thrombocytopenia purpura, heart failure, cardiac damage due to an ischemic event, and diabetes.
ANTIBODIES TO GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR