The present invention relates to a group of piperazine and piperidine derivatives of formula (I), wherein Y is a heteroaryl group optionally substituted by one or more halogen, nitro, C1-6alkyl, C1-6alkoxy, aryloxy, arylC1-6alkylenoxy, hydroxy, S(O)nR<2> or S(O)nN(R<2>)2 where n is 0, 1 or 2, CN, CON(R<2>)2, COR<2>, CO2R<2>, CO-aryl, azido, -N(R<2>)2, -NR<2>N(R<2a>)2, -NR<2>N = C(R<2a>)2, -NR<2>(C = O)CH(N(R<2a>)2)R<2b>, -NR<2>(C = O)R<2a>, NR<2>CO2R<2a>, C1-6alkoxycarbonylamino or PhN = N; with the proviso that Y does not include benzisothiazolyls or benzisoxazolyis, V is O or S; Z is C1-8alkylene optionally interrupted by -O- or -S(O)n- where n is 0, 1 or 2, C2-8alkenylene or C2-8alkynylene; X is N, CR<3> or COR<3>; A is CR<4> or N; B is oxygen, NR<5> or S(O)n, where n is 0, 1 or 2; and R<1> is hydrogen or one or more halogen, hydroxy, nitro, CN, NR<6>2, C1-6alkoxy, aryloxy, arylC1-6alkylenoxy, or COR<6>, R, R<2>, R<2a>, R<2b>, R<3>, R<4>, R<5> and R<6>, are each hydrogen or C1-6alkyl; or a salt, solvate, N-oxide or physiologically functional derivative thereof, to processes for their preparation, to pharmaceutical compositions containing them and to their use in therapy, in particular in the treatment of psychotic disorders.
HETEROAROMATIC COMPOUNDS WITH ANTIPSYCHOTIC ACTIVITY.