598912 Disclosed herein is a compound of formula I wherein the variables are defined in the specification, and the use thereof for the treatment of cognitive, neurodegenerative, psychiatric or neurological disease or disorder such as mood disorder, an anxiety, a schizophrenia, Alzheimer's disease, Parkinson's disease, multiple sclerosis, Huntington's chorea, amyotrophic lateral sclerosis, Creutzfeld-Jakob disease, a trauma-induced neurodegeneration, AIDS-induced encephalopathy, a non-AIDS-induced encephalopathy, Fragile X syndrome, an autism spectrum disorder, and a combination thereof. Additionally for the treatment of gastroesophageal reflux disease or disorder. Additionally for the treatment of alcohol dependence. Exemplary compounds include: pyridine-2-carboxylic acid [9-fluoro-2-(3-fluoro-phenyl)-9-methyl-1-oxo-2-aza-spiro[4.5]dec-7-yl]-amide; 2-methyl-pyrimidine-4-carboxylic acid [2-(3,5-difluoro-phenyl)-8-fluoro-1-oxo-2-aza-spiro[4.5]dec-7-yl]-amide; and 2-methyl-pyrimidine-4-carboxylic acid [2-(4-fluoro-phenyl)-4-hydroxy-4-methyl-1-oxo-2-aza-spiro[4.5]dec-7-yl]-amide.
SPIROLACTAM DERIVATIVES AND USES OF SAME