PCT No. PCT/GB95/02687 Sec. 371 Date Jul. 21, 1997 Sec. 102(e) Date Jul. 21, 1997 PCT Filed Nov. 15, 1995 PCT Pub. No. WO96/16056 PCT Pub. Date May 30, 1996A class of N-substituted piperazine, piperadine and tetrahyrdopyridine derivatives of formula (I), further substituted at the 4-position by an optionally substituted aryl-alkyl or heteroaryl-alkyl moiety, are selective agonists of 5-HT1-like receptors, being potent agonists of the human 5-HT1D alpha receptor subtype relative to the 5-HT1D beta subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT1D receptors is indicated, whilst eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT1D receptor agonists. In formula (I) Z represents -SO2NR5R6, or a group of formula (b). <IMAGE> (I) <IMAGE> (b)
Piperazine, piperidine and tetrahydropyridine derivatives useful as 5-HT1 recepter agonists