Benzoyl piperidines and pyrrolidines and compounds of related structure (Formula I) are disclosed for use in enhancing synaptic responses mediated b y AMPA receptors. The compounds are effective in the treatment of subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number or strength of excitatory synapses or in the numb er of AMPA receptors. The compounds can also be used for the treatment of non- impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors, for improving the performance of subjects with memory deficiencies, for treating depressio n, alcoholism and schizophrenia, and for improving memory encoding.
BENZOYL PIPERIDINES/PYRROLIDINES FOR ENHANCING SYNAPTIC RESPONSE