The invention provides a method for selecting a medicament for regulating sleep. The method comprises the step of determining the influence of candidate medicaments on the activity and/or expression of nAChR[alpha]2 and/or nAChR[beta]2. The medicament can be useful for treating and preventing sleep disorders or delaying the progression of the sleep disorders. Further, the invention provides a method for determining the possibility that a subject has the sleep disorders and/or is in the risk of having the sleep disorders. The invention also provides a non-human organism or a living part thereof.
AchR, sleep and wakefulness