Systems and methods are provided for neuromodulation with simultaneous stimulation and reception of neuronal response. A closed-loop control system provides the ability to modulate any combination of at least five parameters of stimulation (magnitude, frequency, amplitude, time, and phase) based on any combination of at least five parameters of received signals. The neuromodulation is well-suited for deep brain stimulation (DBS) applications.
System and method for feedback-driven neuromodulation