The present invention involves methods and systems for treatment of brain disorders using neuromodulation that is provided to modulate structures of brain networks. Treatment occurs using electrical, optical, magnetic, and/or chemical stimulation of one or more brain networks associated with a brain disorder. The methods involve using a brain modulation system (BMS) to increase, decrease, or otherwise modulate characteristics of the regions of the network, such as relative levels of electrical activity or neurotransmitter levels. Treatment can be initiated and adjusted based upon evaluation of functional neuroimaging data for the network and brain network modeling. Linking rules may guide in adjusting the treatment protocol used to provide neuromodulation of multiple regions of a brain network. Novel methods are described for addressing issues of compensation, adaptation, and unintentional modulation due to indirect stimulation that can arise due to connectivity between structures within brain networks.
Systems and methods for treating disorders of the central nervous system by modulation of brain networks