The present invention addresses the problem of developing a therapeutic drug and treatment method for suppressing the advance of ALS by elucidating the condition and etiology of the disease, especially in sporadic ALS patients. Sporadic ALS patients were classified as four types on the basis of the advance of the condition after onset. Genome-wide association analysis was conducted, and seven SNPs related to the rapidly progressive type that exacerbates rapidly, among the four types, were discovered. It also became apparent that the SNPs are related to titin expression. The SNPs and titin expression can serve as markers of rapidly progressive ALS, and therapeutic and prophylactic methods for suppressing the condition can be developed using these markers.
RAPIDLY PROGRESSIVE SPORADIC ALS TEST METHOD, TEST KIT, AND DRUG SCREENING METHOD