A peptide of the formula: NH2- alpha - beta gamma delta epsilon eta THETA kappa lambda mu pi - rho -CO2H, wherein alpha is an amino acid having an R value of 4.5 +/- 1 unit; beta is an amino acid having an R value of 3.9 +/- 1 unit; gamma is an amino acid having an R value of -3.8 plus 1 unit; delta is an amino acid having an R value of -1.8 +/- 1 unit; epsilon is an amino acid having an R value of -4.2 +/- 1 unit; eta is an amino acid having an R value of -1.3 +/- 1 unit; THETA is an amino acid having an R value of 0.9 +/- 1 unit; kappa is an amino acid having an R value of 0.8 +/- 1 unit; lambda is an amino acid having an R value of 0.8 +/-1 unit, mu is an amino acid having an R value of -1.3 +/- 1 unit; pi is an amino acid having an R value of 3.9 +/- 1 unit; and rho is from 1 to about 18 amino acid residues having an average R value of at least about 0 +/- 1 unit; and wherein both alpha and the last residue of rho comprise hydrophilic end groups; or alpha is from 1 to about 18 amino acid residues having an average R value of at least about 0 +/- 1 unit; beta , gamma , delta , epsilon , eta , THETA , kappa , lambda , mu and pi are as defined above and rho is an amino acid having an R value of -1.3 +/- 1 unit; and wherein both the first residue of alpha and rho comprise hydrophilic end groups.
RECEPTOR BLOCKING PEPTIDES OF FIBROBLAST GROWTH FACTOR RECEPTOR