The present invention provides dihydrazone compounds having high affinity to Aβ protein and Tau protein and derivatives thereof. The structure of said compounds is as shown in formula (I): (I). Such compounds can be directly used as fluorescent probes for detecting neurofibrillary tangles in vivo or in a tissue sample, and when used in nuclear medicine imaging, the compounds need to be labelled using a suitable radioactive isotope. Such compounds are particularly useful for diagnosing patients with neurodegenerative diseases, including Alzheimer's disease, having the characteristics of Aβ plaques and neurofibrillary tangles.
DIHYDRAZONE COMPOUNDS HAVING HIGH AFFINITY TO AΒ PROTEIN AND TAU PROTEIN, DERIVATIVES THEREOF AND USE THEREOF