Systems and methods are provided for generating a protocol independent image. A deep learning generative framework learns to recognize the boundaries and classification of tissues in an MRI image. The deep learning generative framework includes an encoder, a decoder, and a discriminator network. The encoder is trained using the discriminator network to generate a latent space that is invariant to protocol and the decoder is trained to generate the best output possible for brain and/or tissue extraction.
Protocol independent image processing with adversarial networks