Genetic, biochemical, biophysical and anatomical information is integrated a t the subcellular, cellular, tissue and organ level. At least one database containing biological information is used to generate at least one data structure having at least one attribute associated therewith. An interface interactively views, edits or links together attributes of the data structur es to create at least one hierarchical description of subcellular, cellular, tissue and organ function. The hierarchical description may optionally be an elementary, binary or pathway data structure, or, alternatively, an anatomic al data structure capable of being modified to form a structural model. A computational engine mathematically generates at least one data structure fr om the hierarchical description. Genetic information is accessed, tabulated and combined with functional information on the biochemical and physiological ro le of gene products. Computational models of genetic, biochemical and biophysic al processes within cells and higher order systems are automatically formulated , solved and analyzed based on combination of genetic and functional informati on adduced. A dynamic tool is thereby provided for achieving discernible objectives, such as increased understanding of biological processes, identification of newdrug targets for therapeutic intervention and predictions involving the outcome of drug screening. These objectives are accomplished by the realization of highly complex nonlinear dynamic interactions that occur between each gene or gene product.
SYSTEM AND METHOD FOR MODELING GENETIC, BIOCHEMICAL, BIOPHYSICAL AND ANATOMICAL INFORMATION: IN SILICO CELL