PROBLEM TO BE SOLVED: To provide a novel method for treating TNFα-related disorders safely and effectively.SOLUTION: Provided is a multiple-variable dose method for treating TNFα-related disorders comprising the steps of: administering at least one inducing dose of a TNFα inhibitor to a subject in need to obtain the threshold level of the TNFα inhibitor during the induction phase; and administering at least one treatment dose of the TNFα inhibitor to the subject during the therapeutic phase. The TNFα inhibitor is preferably a human TNFα antibody or antigen-binding fragments thereof, etanercept or infliximab. According to the method, TNFα-related disorders including Crohn's disease, ulcerative colitis, psoriasis, autoimmune diseases such as rheumatoid arthritis, infections, graft rejection or graft versus host disease, malignant tumors, pulmonary diseases, intestine diseases, cardiac diseases, septicemia, spondyloarthropathy, metabolic disorders, anemia, pain, hepatic diseases, skin diseases, nail disorder and vasculitis can be safely and effectively treated.
MULTIPLE-VARIABLE DOSE REGIMEN FOR TREATING TNFα-RELATED DISORDERS