A system to measure and monitor neurodegeneration of a subject, in particular preclinical Alzheimer's disease, comprises an acquisition module configured to acquire electroencephalographic signals with multiple EEC channels from a subject perceptually isolated (101); a calculation module configured to extract at least one EEC metric representative of neurodegeneration (102); and an evaluation module configured to evaluate the at least one EEC metric and extract a neurodegeneration index (103). The EEC metric is selected from the group of: weighted symbolic mutual information in at least one frequency band, power spectral density calculated in at least one frequency band, median spectral frequency, spectral entropy, algorithmic complexity.
SYSTEM AND METHOD TO MEASURE AND MONITOR NEURODEGENERATION