The present invention discloses an interaction between .beta.-APP and HsLON and the formation of a .beta.-APP:HsLON complex, or of the derivatives, fragments, analogs and homologs thereof, that were identified using a modified, improved yeast two hybrid assay system. Methodologies of screening these aforementioned complexes for efficacy in treating and/or preventing various diseases and disorders, particularly neurodegenerative disease, cardiomyopathy, diabetes, hearing loss, male infertility, mitochondrial DNA mutation associated disorders and the like, are also disclosed herein.</SDOA B>
INTERACTION OF HUMAN BETA AMYLOID PRECURSOR PROTEIN (.BETA.-APP) WITH HUMAN LON-PROTEASE LIKE PROTEIN (HSLON)