PROBLEM TO BE SOLVED: To provide an effective treatment agent for psychosis, schizophrenia, cognitive disorder, cognitive impairment related to schizophrenia, attention deficit hyperactivity disorder, autism spectrum disorder, Alzheimer's disease, mild cognitive impairment, memory impairment associated with aging, senile dementia, AIDS dementia, Pick's disease, dementia associated with Lewy bodies, dementia related to Down's syndrome, Huntington's disease, Parkinson's disease, obsessive-compulsive disorder, traumatic brain injury, epilepsy, post-traumatic stress, Wernicke-Korsakoff syndrome, post-traumatic amnesia, cognitive impairment related to depression, diabetes, weight control, inflammatory disorder, decreased angiogenesis, amyotrophic lateral sclerosis and pain.SOLUTION: Such diseases are treated by using a nicotinic acetylcholine α7 receptor positive allosteric modulator (PAM) represented, for example, by the following formula.
NICOTINIC ACETYLCHOLINE RECEPTOR POSITIVE ALLOSTERIC MODULATOR (PAM)