l[ -ali Lultrb .IMP.Lor[XL~DAR [5%=||~'T| I d...,- fl'r IU|~ Provided herein are methods for treating chronic pain by administering low doses of buprenorphine twice daily (or once daily) via a transmucosal drug delivery device. The methods and devices efficiently treat chronic pain without significant side effects. Study Design Schematic Strhiflg *CLEP - 60 rn ort]l Imr Olural/day pigb - rn intertiiLy (P1) score 6 4-Ineek Open Label Randcrnzed Titratin Perrod -- Double Blind Da S A, ZYA, 3XA, 4xA rng; bid Treatmentred Eriodstuddy -tBEMA OuprerIor phni5 D-on1rued Figure 1.
Transmucosal drug delivery devices for use in chronic pain relief