Disclosed is a polypeptide comprising an anti-CX3CR1 (anti-CX3 chemokine receptor 1) immunoglobulin single variable domain, wherein said anti-CX3CR1 immunoglobulin single variable domain consists essentially of four framework regions (FR1, FR2, FR3 and FR4) and three complementary determining regions (CDR1, CDR2 and CDR3) and wherein said polypeptide comprises a CDR1, CDR2 and CDR3 having the amino acid sequences: - GSIFSSTAMA, AISTVGVTK and DPRRGWDTRY, respectively; or - GSIFSSNAMA, AINSVGVTK and DPRRGWDTRY, respectively; or - GSIFSSNAMA, GINSVGITK and DPRRGWDTRY, respectively; or - GSIFSSNAMA, AINSVGITK and DPRRGWDTRY, respectively; or - GSIFSSNAMA, LINSVGITK and DPRRGWDTRY, respectively; or - GSIFSSNAMA, VINTVGITK and DPRRGWDTRY, respectively; or - GSIFSSNAMA, GINSVGIAK and DPRRGWDTRY, respectively; or - GSIFSSNAMA, VINKVGITK and DPRRGWDTRY, respectively; or - GSIFSSNAMA, AINSVGTTK and DPRRGWDTRY, respectively; or - GSIFSSNAKA, GINSVGITK and DPRRGWDTRY, respectively; or - GSIFSSNAMA, AISSVGVTK and DPRRGWDTRY, respectively; or - GSIFSSNAMA, AIQSVGVTK and DPRRGWDTRY, respectively; or - GSIFSSNAMA, AIGSVGVTK and DPRRGWDTRY, respectively; or - GSIFSSNAMA, AITSVGVTK and DPRRGWDTRY, respectively; or - GSIFSSNAMA, AINTVGVTK and DPRRGWDTRY, respectively; or - GSIFSSNAMA, AINGVGVTK and DPRRGWDTRY, respectively; or - GSIFSSNAMA, AINPVGVTK and DPRRGWDTRY, respectively; or - GSIFSSTAMA, AISSVGVTK and DPRRGWDTRY, respectively.
Cx3cr1-binding polypeptides