Disclosed is a mouse which can utter sounds within the human audible range. Also disclosed is a mouse whose emotions can be easily understood depending on the sounds uttered by the mouse. A mouse having powerful voice within the human audible range compared with the voice within the human non-audible range can be obtained by repeatedly crossing mice lacking the 3'-5' exonuclease activity of DNA polymerase d with each other. As the above-described mouse lacking the 3'-5' exonuclease activity of DNA polymerase d, a mouse obtained by crossing mice carrying a mutated protein, in which aspartic acid at the 400-position in the amino acid sequence represented by SEQ ID NO:1 has been substituted by another amino acid, with each other can be cited. By crossing such mice as described above with each other, a mouse with a singing mutation can be obtained.
MOUSE WITH SINGING MUTATION