The present invention includes benzodiazepine compositions formulated for intranasal administration, comprising a binary solvent system comprising a first solvent in which the benzodiazepine is soluble, the first solvent capa ble of penetrating nasal mucosal tissue, and a second solvent in which the b enzodiazepine in less soluble. The compositions of the present invention may be used to treat a variety of disorders including, but not limited to, pani c attacks, muscle spasms, anxiety, and seizures. In one aspect, the present invention relates to a fast-acting, clonazepam composition for transnasal ad ministration that can be used for the treatment of seizure clusters.
PHARMACEUTICAL COMPOSITIONS OF CLONAZEPAM AND METHODS OF USETHEREOF