To provide improved treatments of migraine and other related diseases with compounds that provide increased efficacy and reduced undesirable side effects.SOLUTION: The invention relates to methods for treating migraine (e.g., episodic migraine, chronic migraine, retinal migraine, ophthalmoplegic migraine, acephalgic migraine, migrainous disorder, menstrual migraine, abdominal migraine, childhood periodic syndromes, or cluster headache) by administering a peptide NMDAR partial agonist. The invention also relates to methods for treating or ameliorating long-term post-migraine sequelae in a patient by administering a peptide NMDAR partial agonist. The invention also relates to methods for treating, suppressing and/or preventing cortical spreading depression or a disease or condition caused by cortical spreading depression in a patient in need thereof, comprising administering a peptide NMDAR partial agonist.SELECTED DRAWING: None
METHODS OF TREATING OR AMELIORATING MIGRAINE