A multi-modal functional OCT imaging methodology and system are provided that enable concurrent intrinsic optical signal (IOS) imaging of stimulus-evoked neural activity and hemodynamic responses at capillary resolution. An OCT angiography (OCTA)- guided IOS analysis is used to separate neural-lOS and hemodynamic-lOS changes in the same retinal image sequence. The OCTA-guided IOS data processing used for this purpose differentiates two functional images, namely. a neural-IOS map and a hemodynaniic-IOS map, from the same image dataset.
AN OPTICAL COHERENCE TOMOGRAPHY (OCT) SYSTEM AND METHOD THAT MEASURE STIMULUS-EVOKED NEURAL ACTIVITY AND HEMODYNAMIC RESPONSES