PROBLEM TO BE SOLVED: To provide methods of diagnosing and treating intestinal granulomas and low bone density in inflammatory bowel disease.SOLUTION: The present invention relates to a method of diagnosing inflammatory bowel disease (IBD) in an individual by determining the presence of at least one risk genetic variant and/or at least one risk serological marker. In one embodiment, the presence of at least one risk genetic variant is indicative of granuloma. In another embodiment, the presence of at least one risk genetic variant is indicative of low bone density (LBD).SELECTED DRAWING: None
METHODS OF DIAGNOSING AND TREATING INTESTINAL GRANULOMAS AND LOW BONE DENSITY IN INFLAMMATORY BOWEL DISEASE