An implantable transcranial pulse generator for generating neuro-modulating electrical signals used, for example, in the treatment of medical conditions through de ep brain stimulation (DBS). The implantable pulse generator comprises a collapsible dome portion that deforms upon impact to protect the patient from injury and the pulse generator from being damaged. The dome is removably mounted to a transcranial insert that i s secured within a burr hole located in the patient's cranium. Both the dome and the insert contain electronic components and have complementary connectors facilitating direct electrical interconnection. The electronics within the dome are mounted on flexible substrates to permit deformation of the collapsible portion. The dome may include a re-fillable reservoir for supplying controlled dosages of a pharmaceutically active composition to the brain through the transcranial insert.
IMPLANTABLE TRANSCRANIAL PULSE GENERATOR HAVING A COLLAPSIBLE PORTION