Compounds of the formula (I) wherein A is unbranched C3-C5 alkylene optional ly substituted by C1-C6 alkyl; X is O, S, NH or N(C1-C6 alkyl); Y is O, S, NH or N(C1-C6 alkyl); R is a C-linked, 4- to 6- membered ring, non-aromatic, heterocyclic group containing one nitrogen heteroatom, said group being optionally substituted by 1, 2 or 3 substituent(s) each independently selected from C1-C6 alkyl, C2-C6 alkenyl, C3-C7 cycloalkyl, aryl, het, -CO2(C1-C6 alkyl), -CO(het), - CONR5R6 and -CO(aryl), said alkyl and alkenyl being optionally substituted by 1 or 2 substituent(s) each independently selected from C3-C7 cycloalkyl, aryl, het, -O(aryl), -O(C1-C2 alkylene) aryl, -CO(het), -CONR5R6 and -CO(aryl); are inhibitors of rotamase enzymes i n particular FKBP-12 and FKBP-52. The compounds therefore moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases or other disorders involving nerve damage.
HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES