A neural signal recording method and system combining in vivo patch-clamp recording and optical fiber recording. The neural signal recording system comprises a fluorescence signal recording unit (1), an excitation unit (2), a patch-clamp recording unit (3), and a control and processing unit (4); the patch-clamp recording unit (3) comprises an electrophysiological digital-to-analog converter (34); the fluorescence signal recording unit (1) records a fluorescence signal; the patch-clamp recording unit (3) records a neuroelectric signal; the fluorescence signal and the neuroelectric signal are synchronized in the electrophysiological digital-to-analog converter (34). The present invention can reflect both changes in membrane potentials such as pulse discharge and changes in neurochemical signals of associated loops, and has qualitative improvement in the dimension and form of neural signal recording and the richness of obtained data.
NEURAL SIGNAL RECORDING METHOD AND SYSTEM COMBINING IN VIVO PATCH-CLAMP RECORDING AND OPTICAL FIBER RECORDING