Systems and methods for automated voxel positioning in magnetic resonance spectroscopy (“MRS”) are provided. In some aspects, a method includes receiving magnetic resonance (“MR”) imaging data acquired from a subject using an MR imaging system and registering the MR imaging data to an atlas having a pre-defined volume of interest (“VOI”), or segmenting a region of interest (“ROI”) directly from the MR data. The method also includes generating registration parameters based on the registration, and computing a transformed VOI using the pre-defined VOI in the atlas and the registration parameters. Alternatively, the VOI may be obtained by directly estimating it from the ROI.
Systems and methods for automatic voxel positioning in magnetic resonance spectroscopy