The present invention provides for a recombinant nucleic acid molecule comprising a humanized mouse /3-amyloid precursor protein ('APP') gene comprising K670N, M671L and V717F mutations and uses thereof. The present invention further provides for a recombinant nucleic acid molecule comprisin g a region of a calcium-calmodurin dependent kinase Il.alpha. ('CaMKIIa') promoter operatively linked to a /3-amyloid precursor protein ('APP') gene comprising at least one mutation and uses thereof.
TRANSGENIC ALZHEIMER'S MOUSE MODEL VECTORS AND USES THEREOF