Provided is a chimeric antigen receptor. The chimeric antigen receptor sequentially contains, from N-terminus to C-terminus, a membrane protein signal peptide, T1E peptide and Herin peptide linked by a linker, a hinge region with 50 or more amino acid residues, a transmembrane domain, a costimulatory signal molecule intracellular domain, and an immunoreceptor tyrosine-based activation motif. Also provided are a chimeric antigen receptor-modified T cell (CAR-T) and an application thereof.
ERBB RECEPTOR FAMILY-TARGETED CHIMERIC ANTIGEN RECEPTOR-MODIFIED T CELL (CAR-T) AND APPLICATION THEREOF