The invention provides a selective Sigma 1 or Dopamine D3 receptor agonist or a 5HT2c receptor ligand for use in the treatment of symptoms of anxiety and/or depression associated with an affective disorder and/or symptoms associated with cognitive impairment disorder. Particularly useful are diphenhydramine derivatives of Formula (I) and particularly (2-[(4-butylsulfanylphenyl)-phenyl-methyl] sulfanyl-N,N-dimethyl- ethanamin) (Captodiamine).
GROWTH FACTOR MODULATORS FOR THE TREATMENT OF ANXIETY, DEPRESSION AND COGNITIVE DISORDERS