PROBLEM TO BE SOLVED: To provide a method of using p11 as a drug target as well as a tool for the diagnosis, treatment and development of p11/5-HT receptor-related disorders.SOLUTION: A method of diagnosing p11/5-HT receptor-related disorders includes steps of; determining a level of p11 in a biological sample from a subject and comparing the p11 level to a reference, where an abnormal level of p11 compared to the reference constitutes a positive diagnosis of the p11/5-HT receptor-related disorder; using p11 knock-out animals as well as p11 transgenic animals as models for development of novel psychotherapeutic agents; and selecting the p11/5-HT receptor-related disorder from a group consisting of depression, obsessive compulsive disorder, drug addiction, eating disorders, Alzheimer's disease, attention deficit disorder, attention deficit hyperactive disorder, mania, bipolar disorder, anxiety disorders, aggression, sleep disorders, sexual dysfunction and gastrointestinal disorders.SELECTED DRAWING: None
NOVEL THERAPEUTIC AND DIAGNOSTIC PRODUCTS AND METHODS