The invention discloses a method for treatment of epilepsy-associated motor symptom and/or cognitive impairment, by co-administering clavulanic acid and valproic acid to an epilepsy subject in need thereof. Clavulanic acid can be administrated in a dosage of 0.016-10 mg/kg/day, while valproic acid can be administrated in a dosage of 0.8-30 mg/kg/day. Moreover, clavulanic acid and valproic acid can be administrated concurrently, sequentially, separately, continuously or intermittently. In addition, clavulanic acid, as well as valproic acid, can be administrated orally or parenterally.
PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATMENT OF EPILEPSY-ASSOCIATED MOTOR SYMPTOM AND/OR COGNITIVE IMPAIRMENT