Disclosed are novel 2, 3 -benzodiazepine of formula (I), wherein R9 and R10 are alkoxy derivatives, methods of making the same, and their use in treating psychotic disorders. FIG. 1 shows, comparatively, the effect of clozapine, compound 121 and compound 183 on PCP-induced disruption of pre-pulse intensity. FIG. 2 shows, comparatively, the effect of compounds 121 and 183 on locomotor behavior in mice. Formula (I).
NOVEL 2,3-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS ANTIPSYCHOTIC AGENTS