The present invention relates to a composition for diagnosing mild cognitive impairment, comprising a TonEBP antibody as an active ingredient, and has identified cognitive impairment in obesity-induced or obesity and diabetes-induced mice and an increase in the expression of TonEBP proteins in the blood of the mice. In addition, LCN2 proteins also increased in the blood in which the TonEBP proteins had increased. Furthermore, the expression of TonEBP proteins and LCN2 proteins also increased in the blood of obese and diabetic patients diagnosed with mild cognitive impairment, so that the level of protein concentration is measured through the detection of TonEBP proteins or the parallel detection of TonEBP and LCN2 proteins in the blood, and thus patients with mild cognitive impairment can be diagnosed and identified.
COMPOSITION FOR DIAGNOSING MILD COGNITIVE IMPAIRMENT, CONTAINING TONEBP ANTIBODY AS ACTIVE INGREDIENT