A variant PAR-2 receptor polypeptide or a fragment thereof is provided which (i) has reduced sensitivity to trypsin as compared with wild type PAR-2; (ii ) has increased sensitivity to trans-cinnamoyl-LIGRLO-NH2 as compared with wil d type PAR-2; and (iii) is activated by TLIGRL-NH2, which polypeptide or fragment thereof comprises an extracellular loop 2 (ECL-2) having at least o ne amino acid difference from the corresponding ECL-2 amino acid sequence of th e wild type polypeptide.
PROTEASE ACTIVATED RECEPTOR 2 VARIANTS