The present invention relates to a polynucleotide for use in therapy directed at the peripheral and central nervous system in humans for the purpose of treating psychological dependence on, and abuse of, substances which have a stimulating and euphoric effect. In particular, the invention relates to a recombinant plasmid comprising a plurality of sequences that encode for beta-endorphin, said sequences being separated by a proteolytic cleavage site.
Recombinant plasmids and method for treating substance abuse