1. Pseudopolymorph form I of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy-1methyl)piperidinyl]-4H-1-benzopyran-4-one having an x-ray powder diffraction pattern expressed in terms of 'D' spacing: D space- angstrom 2.708 4.323 5.594 5.349 3.590 2. A pseudopolymorph form of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy-1-methyl)piperidinyl]-4H-1-benzopyran-4-one I having an x-ray powder diffraction pattern expressed in terms of 'D' spacing and relative intensities thereof: D space- angstrom Relative Intensity 12.708 Strong 4.323 Strong 5.594 Strong 5.349 Medium 3.590 Medium 3.366 Medium 4.209 Medium 3.395 Medium 3.438 Medium 4.839 Medium 3. A pseudopolymorph form of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy-1-methyl)piperidinyl]-4H-1-benzopyran-4-one I having an x-ray powder diffraction pattern expressed in terms of 'D' spacing and percentage of relative intensities thereof: D space- angstrom Relative Intensity % 12.708 100.0 4.423 75.9 5.594 58.5 5.349 49.5 3.590 46.6 3.366 42.0 4.209 40.7 3.395 39.5 3.438 38.8 4.839 37.1 4. A pseudopolymorph form of (-)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy-1methyl)piperidinyl]-4H-1-benzopyran-4-one having an x-ray powder diffraction pattern as defined in Table 1: Table 1 theta degree D space- angstrom Relative Intensity Relative Intensity % 6.950 12.708 Strong 100.0 20.529 4.323 Strong 75.9 15.830 5.594 Strong 58.5 16.560 5.349 Medium 49.5 24.778 3.590 Medium 46.6 26.457 3.366 Medium 42.0 21.091 4.209 Medium 40.7 26.226 3.395 Medium 39.5 25.898 3.438 Medium 38.8 18.320 4.839 Medium 37.1 8.308 10.634 Medium 35.7 23.748 3.744 Medium 33.4 13.010 6.799 Medium 32.4 30.520 2.927 Medium 31.0 27.106 3.287 Weak 26.2 31.153 2.869 Weak 22.4 29.043 3.072 Weak 23.7 14.600 6.062 Weak 22.4 19.033 4.659 Weak 20.6 5. A method of making the Form I of claims 1,2,3 or 4 comprising (a) combining a sufficient quantity of Form II with a sufficient amount of an appropriate azeotropic solvent, thus forming an azeotropic mixture; (b) submitting the azeotropic mixture to azeotropic distillation sufficient to Form 1; and (c) optionally recovering Form I therefrom. 6. The method of claim 17 wherein the solvent is a ketone solvent. 7. The method of claim 17 wherein the solvent is methyl ethyl ketone. 8. The method of claim 15 wherein the crystallized Form I is recovered by filtering Form I. 9. The method of claim 15 wherein the temperature of the azeotropic distillation is about 73 degree C to about 80 degree C.
PSEUDOPOLYMORPH OF (-)-CIS-2(2-CHLORROPHENYL)-5,7-DIHYDROXY-8[4R-HYDROXY-1-METHYL)PIPERIDINYL]-4H-1-BENZOPYRAN-4-ONE