INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 November 2018 (08.11.2018) WIPO I PCT (51) International Patent Classification: C07K 16/28 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/EP2018/061084 (22) International Filing Date: 01 May 2018 (01.05.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1706915.4 02 May 2017 (02.05.2017) GB 1717958.1 31 October 2017 (31.10.2017) GB 1805873.5 09 April 2018 (09.04.2018) GB (71) Applicant: ALLIGATOR BIOSCIENCE AB [SE/SE]; Medicon Village, SE-233 81 Lund (SE). (72) Inventors: ELLMARK, Peter; Alligator Bioscience AB, Medicon Village, SE-233 81 Lund (SE). FUREBRING, Christina; Alligator Bioscience AB, Medicon Village, SE-233 81 Lund (SE). NORLEN, Per; Alligator Bio- science AB, Medicon Village, SE-233 81 Lund (SE). VEI- TONMAKI, Niina; Alligator Bioscience AB, Medicon Village, SE-233 81 Lund (SE). (74) Agent: SMITH, Stephen Edward; Potter Clarkson LLP, The Belgrave Centre, Talbot Street, Nottingham NG1 5GG (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: BISPECIFIC ANTIBODY AGAINST OX40 AND CTLA-4 - (57) : The present invention provides bispecific polypeptides, such as bispecific antibodies, comprising a first binding domain = capable of specifically binding to OX40, and a second binding domain capable of specifically binding to CTLA-4. The invention further — provides compositions of said bispecific polypeptides, as well as methods and uses of the same. ill 1111u°111110111sOHo o Holonomioomnium (10) International Publication Number WO 2018/202649 Al W O 20 18/ 20 26 49 Al [Continued on next page] WO 2018/202649 Al 0 111 Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))
BISPECIFIC ANTIBODY AGAINST OX40 AND CTLA-4