Disclosed are a recombinant adeno-associated virus vector and a use thereof. The recombinant adeno-associated virus vector is only expressed in dopaminergic neurons in the region of the Substantia nigra, and is not expressed in astrocytes and oligodendrocytes. In addition, an injection of AAV-MANFHIS in the Substantia nigra can effectively improve the behavioral function of rats and can specifically treat neurodegenerative diseases in animals.
RECOMBINANT ADENO-ASSOCIATED VIRUS VECTOR AND USE THEREOF