The present invention identifies autoantibodies to folate receptors. Methods to identify these autoantibodies to the human folate receptors are also provided. The present invention also contemplates diagnostic methods and tes t kits to be used in a clinical setting for identifying a subject at risk of folate-sensitive abnormalities or disorders as observed in neural tube defec t complicatedpregnancies. In addition, infertility, spontaneous abortion, male sterility, unsuccessful in vitro fertilization,neurologic disorders and impaired folate absorption may also be associated with these autoantibodiest o folate receptors.
ASSAY FOR AUTOANTIBODIES TO FOLATE RECEPTORS