Disclosed herein are compound of general formula I, wherein the variables are defined in the specification, and the use thereof in the treatment of acute pain, visceral pain, neuropathic pain, inflammatory/pain receptor-mediated pain, tumour pain, headache diseases and osteoarthritis. In some embodiments the compound includes (S)-6-oxo-1,6-dihydro-pyridazine-4-carboxylic acid-{ 3-[4-(4-chloro-2-trifluoromethyl-phenylamino)-2-fluoro-benzylcarbamoyl]-tetrahydrofuran-3-yl} -amide, and 6-oxo-1,6-dihydro-pyridazine-4-carboxylic acid-(1-{ [5-(4-fluoro-2-trifluoromethyl-phenylamino)-pyridin-2-ylmethyl]-carbamoyl} -cyclopropyl)-amide.
Compounds as bradykinin b1 antagonists