A method for calculating quantitative perfusion measurements using an MRI system includes a pulse sequence that acquires perfusion weighted images and additionally measures T1 values before and after the administration of a contrast agent. T1 values are measured by rapidly sampling a longitudinal relaxation curve and employed to determine the blood volume in tissue. A correction factor for the effect of water diffusion between blood vessels and the extravascular space is determined.
MRI method for quantification of cerebral perfusion