PROBLEM TO BE SOLVED: To provide methods for treating a subject suffering from ischemic event.SOLUTION: The invention provides a method comprising the steps of: (a) administering to a subject an anti-coagulating agent and a protein kinase C (PKC) activator within about 24 hours after the ischemic event; (b) following the step (a), administering at least one PKC activator during the treatment, where the PKC activator of the step (a) and step (b) may be the same or different.EFFECT: Compared to single administration of rTPA, the method will limit the size of infarction, and/or reduce mortality, disruption of the blood-brain barrier, and/or hemorrhagic damage resulting from ischemic stroke, further will extend the therapeutic time window for administering rTPA after a stroke.SELECTED DRAWING: Figure 1
PKC ACTIVATORS AND ANTICOAGULANTS IN STROKE TREATMENT