Disclosed is an isolated or recombinant IL-23-binding protein comprising an antigen binding domain of an antibody, wherein the antigen binding domain specifically binds to human IL-23 but does not significantly bind to a human IL-12p40 subunit and does not significantly bind to a human IL-23p19 subunit when they are not components of human IL-23. Also disclosed is the use of such binding proteins for treating psoriasis, Crohn’s disease or multiple sclerosis.
Anti-il-23 heterodimer specific antibodies