The present invention is directed to compounds of formula (I) which are i nhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheime r's disease. The invention is also directed to pharmaceutical compositions c omprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involv ed.
MACROCYCLIC SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE