Provided is a monoclonal antibody that binds human TrkB and that is produced from the hybridoma ATCC patent deposit PTA-6949, or an antibody that blocks the binding of the monoclonal antibody to human TrkB, and wherein the monoclonal antibody binds an epitope of human TrkB with the sequence ENLVGED and optionally an epitope of human TrkB with the sequence AGDPVP. The antibodies can be used to treat various neurological conditions due to injury or disease.
Anti-TRKB monoclonal antibodies and uses thereof