PROBLEM TO BE SOLVED: To suppress a disease state such as Alzheimer disease and a premenstrual syndrome by administering a specific compound. SOLUTION: This method for suppressing a disease state by an estrogen agonist it to administer an effective amount of a compound of the formula A is CH2 or NR; B, D, E are each CH or N; is a (substituted) phenyl, a (substituted) naphthyl, a (substituted) 3-8C cycloalkyl, etc.; Z<1> is (CH2 )p W(CH2 )q (W is CH2 or CH=CH; (p), (q) are each 0, 1-3), etc.; G is NR<7> R<8> [R<7> , R<8> each are phenyl or a (substituted) 3-10C carbocyclic ring], etc.} and optical or geometric isomers thereof, and nontoxic and medicinally permissible acid adducts, N-oxides, esters and quaternary ammonium salts thereof. Further, the component (A) is preferably cis-6-(4-fluorophenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-5,6,7,8- tetrahydronaphthalen-2-ol, etc.
SUPPRESSION OF DISEASE STATE BY ESTROGEN AGONIST