<P>PROBLEM TO BE SOLVED: To provide a new transgenic animal model. <P>SOLUTION: The transgenic non-human animal harbors a diploid genome comprising a transgene encoding a heterologous APP (amyloid precursor protein) polypeptide comprising the Swedish mutation wherein amino acid residues at positions corresponding to the 595th and the 596th positions in the human APP695 are asparagine and leucine, respectively. The transgenic non-human animal is a transgenic rodent wherein the transgene is expressed to produce a human APP polypeptide having the Swedish mutation, and wherein the polypeptide is processed to ATP-βAPP in an amount to be detectable by using an antibody reactive with the ATF-βAPP without reacting with the APP in a brain homogenate of the transgenic rodent. <P>COPYRIGHT: (C)2009,JPO&INPIT 
TRANSGENIC ANIMAL HARBORING APP ALLELE HAVING SWEDISH MUTATION