To provide methods for generating sensory cells in the inner ear of a human in need thereof.SOLUTION: Disclosed is a method comprising a step of administering a composition containing an adenoviral vector and a pharmaceutically acceptable carrier to the inner ear of a human, where the adenoviral vector comprises: (a) a specific serotype 5 adenoviral genome; (b) SV40 early polyadenylation sequence; (c) a specific nucleic acid sequence encoding a human atonal homolog-1 protein; (d) a human glial fibrillary acidic protein promoter; and (e) a transcription-inactive spacer, where the elements (b), (c) and (d) are located in sequence from 3' to 5' relative to the adenoviral genome in E1 region of adenoviral genome, an element (e) is positioned between the E4 polyadenylation sequence and the E4 promoter in the adenoviral genome E4 region.SELECTED DRAWING: None
ADENOVIRAL VECTORS ENCODING HUMAN ATONAL HOMOLOG-1 (HATH1)