Methods and products for the treatment or prevention of pain and the reduction of nociception are described, comprising the modulation of neuroglia-derived brain-derived neurotrophic factor (BDNF) expression or activity in a mammalian host by the administration of an agent such as the P2X receptor inhibitor, TNP-ATP, a BDNF antisense molecule or BDNF siRNA. Related methods for identifying or characterizing compounds for the treatment or prevention of pain and the reduction of nociception are also described.
MODULATION OF NEUROGLIA-DERIVED BDNF IN THE TREATMENT AND PREVENTION OF PAIN