The purpose of the present invention is to provide a composition for preventing or treating neurotrophic keratitis. The inventor finds that PACAP peptide plays a role in inhibiting corneal injury in a neurotrophic keratitis model and promotes nerve axonal extension in a cultured nerve cell model. Furthermore, provided are: a composition for preventing or treating neurotrophic keratitis, which contains a PACAP peptide or a stabilized PACAP peptide, and which has significantly improved stability by substituting the carboxyl group of the aspartic acid at position 3 and/or position 8 in the PACAP sequence with a tetrazole; and a nerve axis extension promoter.
Composition for preventing or treating neurotrophic keratitis, containing PACAP peptide or PACAP-stabilized peptide