This invention relates to disease detection by imaging. Previously, there was no way to use CEST MRI imaging to detect and map the accumulation of amyloid beta, neurofibrillary tangles, and aggregation proteins and peptides. Embodiments of the present invention use a non-invasive CEST MRI imaging method is disclosed for early detection and mapping the severity of diseases by using MRI. The endogenous (MRI) contrast of the biological tissue can rely on the endogenous protons of the proteins and peptides as a source of the contrast, such as hydroxyl, amine, and amide protons, and thereby provide imaging of the accumulation of amyloid beta, accumulation of neurofibrillary tangles, aggregation proteins and peptides, the hypoxia in cancer and non-cancer tissue, the tissues atrophy, distinguish the edema from the tumor, determine tumor boundary, monitor response of tumor to treatment and detect lower grade tumor by using endogenous protons contrast via CEST MRI.
NON-INVASIVE IMAGING METHOD FOR EARLY DETECTION AND MAPPING THE SEVERITY OF DISEASES