A class of indole derivatives, substituted at the 3-position by an optionally substituted dihydroisoindolylmethyl or tetrahydroisoquinolylmethyl moiety, are antagonists of dopamine receptor subtypes within the brain, having a selective affinity for the dopamine D4 receptor subtype over other dopamine receptor subtypes, and are accordingly of benefit in the treatment and/or prevention of psychotic disorders such as schizophrenia whilst manifesting fewer side-effects than those associated with classical neuroleptic drugs.
INDOLE DERIVATIVES AS DOPAMINE D4 ANTAGONISTS