Methods and systems for skull-based brain imaging. In some examples, a method includes receiving a first brain image of a brain taken at a first time and a second brain image of the brain taken at a second time; characterizing a structural change of brain tissue of the brain between the first time and the second time by: determining a global linear change of brain tissue using the first brain image and the second brain image; and determining a local deformation of brain tissue using the first brain image, the second brain image, and the global linear change of brain tissue; and outputting one or more parameters characterizing the structural change based on the global linear change of brain tissue and the local deformation of brain tissue.
POSITIONAL BIOMARKERS BASED ON BRAIN IMAGING