A dual-functioning electrochemical sensing device has invented for fast, direct ultrasensitive detection of protein, such as attomolar concentration (aM) Matrix Metalloproteinase (MMP) without a procedure of cycteine switch under label-free, probe-free and reagent-free conditions. The invented device comprises of an organic memcapacitive/memristive membrane by self-assembling forming polarized 3D array crossing-nanotube structures on a gold substrate that enables the membrane selectively induction of bio-communication with MMP-2 in the absence of interference from other proteins in human serum specimens, herein aM concentration MMP-2 can be reliably detected by two different methods.
Organic Nanobiomimetic Memristive/Memcapacitive Devices Ultrasensitive Direct Detect Matrix Metalloproteinase