<P>PROBLEM TO BE SOLVED: To provide a method for implanting a producer cell into the mammalian brain. <P>SOLUTION: The producer cell is engineered with a retroviral based recombinant vector encoding a tumorcidal factor or susceptibility factor that confers on tumor cells sensitivity to chemotherapeutic or radiotherapeutic agents. Prior to transplantation into the mammalian brain, the producer cell is first cultured in vitro on a support matrix to increase the long-term viability of the transplanted cell and to provide long-term functional benefit. <P>COPYRIGHT: (C)2005,JPO&NCIPI 
METHOD FOR GENE TRANSFER TO CENTRAL NERVOUS SYSTEM