A multiplexed OCT imaging system includes a plurality of sample arms (410), an imaging engine (420), and an optical controller (425). The sample arms are optically coupled to the imaging engine via the optical controller; the optical controller multiplexes optical signals from the sample arms to permit some of the sample arms to operate sequentially or simultaneously. A combination includes an OCT system (750), an optical instrument (780), optics defining an optical path (755) from the optical instrument to a target, and secondary optics (770) for coupling the OCT system to the optical path. This combination permits simultaneous operation of the OCT system and the optical instrument. An electrode carrier (1410) includes multiple electrodes, each electrode having a contact (1470) located at a different position along a distal end of the carrier, and multiple optical fibers (1460), each associated with one of the electrodes and having an end face proximate to the contact of the associated electrode. Each optical fiber end face may capture optical information from tissue adjacent to the associated contact. The electrode carrier may be used for interfacing with an OCT system and a neural signal system.
MULTIPLEXED OCT IMAGING; COMBINED OCT AND VISUAL IMANGING; COMBINED OCT IMAGING AND NEURAL SIGNALING