PROBLEM TO BE SOLVED: To provide computational models and methods for predicting in silico response of one or more pathways in a diseased cell or tissue and recommending multi-drug treatments for treatment-naive patients.SOLUTION: A pathway model database stores multiple distinct data sets derived from omics data of multiple distinct diseased cells, respectively, and each data set comprises a plurality of pathway element data. A machine learning system then receives at least some of the plurality of distinct data sets and identifies a determinant pathway element in the distinct data sets associated with a status of a treatment parameter of the diseased cells. A pathway analysis engine then receives at least one of the distinct data sets from the diseased cells, and the determinant pathway element in the data set is then modulated in the pathway analysis engine to produce a modified data set.SELECTED DRAWING: Figure 4
PARADIGM DRUG RESPONSE NETWORKS