The present invention relates to an image processing device (10) comprising a data input (11) for receiving volumetric image data comprising a plurality of registered volumetric images of an imaged object, a noise modeler (12) for generating a noise model indicative of a spatial distribution of noise in each of the plurality of registered volumetric images, a feature detector (13) for detecting a plurality of image features taking the volumetric image data into account, and a marker generator (14) for generating a plurality of references indicating feature positions of a subset of the plurality of detected image features, in which said subset corresponds to the detected image features that are classified as difficult to discern on a reference volumetric image in the plurality of registered volumetric images based on a classification and/or a visibility criterium, wherein the classification and/or the visibility criterium takes the or each noise model into account.
IMAGE FEATURE ANNOTATION IN DIAGNOSTIC IMAGING