Systems and methods for producing imaging biomarkers that indicate a tissue state in the nervous system of a subject based on diffusion tensor imaging (“DTI”) of the subject's spinal cord or brain are provided. The imaging biomarker can indicate a tissue state in the central nervous system (e.g., brain or spinal cord) of a subject based on DTI of the subject's spinal cord. As another example, however, the imaging biomarker can indicate a tissue state in the subject's spinal cord based on DTI of the subject's brain. The imaging biomarker is also capable of determining an efficacy of a treatment administered to a subject's spinal cord.
Methods for Generating Imaging Biomarkers Based on Diffusion Tensor Imaging of the Spinal Cord