PCT No. PCT/GB92/02229 Sec. 371 Date Jun. 1, 1994 Sec. 102(e) Date Jun. 1, 1994 PCT Filed Dec. 1, 1992 PCT Pub. No. WO93/11138 PCT Pub. Date Jun. 10, 1993 <IMAGE> (I) This invention concerns compounds of formula (I) wherein E represents hydrogen, C1-C6 alkyl or a group Ar1-A1; Ar and Ar1 when present each represent an aryl group of 6 to 10 carbon atoms or a heteroaryl group of 5 to 10 ring atoms wherein the heteroatoms are selected from oxygen, nitrogen and sulphur, which may be optionally substituted by one or more substituents selected from alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, halogen, haloalkyl of 1 to 6 carbon atoms, haloalkoxy of 1 to 6 carbon atoms, cyano, amino, mono- or di-(C1-C6) alkylamino, hydroxy and nitro; A and A1 when present are the same or different alkylene groups having one or two carbons linking Ar or Ar1 to N, each optionally substituted by alkyl of 1 to 6 carbon atoms or an optionally substituted Ar group as defined above, B is a straight chain alkylene group of 3 or 4 carbon atoms optionally substituted by alkyl of 1 to 6 carbon atoms, and D represents one of the following <IMAGE>yl of 1 to 6 carbon atoms or aralkyl of 7 to 12 carbon atoms; R3 is -CH(Oalkyl)2 in which the alkyl group contains 1 to 6 carbon atoms and R4 is alkyl of 1 to 6 carbon atoms or aralkyl of 7 to 12 carbon atoms, which compounds are GABA autoreceptor agonists useful as antidepressants and for treating senile dementia.
Amine derivatives containing a phosphonic acid moiety