Provided is a use of a ferroptosis inhibitor in preparing a preparation for improving the motor function of a senescent individual. Transcriptome sequencing analysis has shown that TfR1 expression in skeletal muscle and muscle satellite cells decreases with increasing age. Muscle satellite cell-specific knockout of TfR1 results in irreversible inactivation of muscle satellite cells. The skeletal muscle regeneration process in TfR1 muscle satellite cell-specific mice is accompanied by muscle atrophy, iron ion accumulation and increased unsaturated fatty acid biosynthesis, thereby inducing skeletal muscle ferroptosis. Senescent skeletal muscle exhibits a decrease in TFR1 expression, while membrane surface accumulation of Slc39a14 promotes increased absorption of iron via binding with non-iron transport proteins, promoting the occurrence of ferroptosis. Intraperitoneal injection of ferrostatin-1 in senescent mice can significantly ameliorate muscle regeneration difficulties and motor difficulties caused by skeletal muscle death.
USE OF FERROPTOSIS INHIBITOR IN PREPARING PREPARATION FOR IMPROVING MOTOR FUNCTION OF SENESCENT INDIVIDUAL