APCOR TUMOR CELL APC OR TUMOR CELL REINVIGORATED T CELL CYTOKINES EFFECTOR MECHANISMS INHIBITORY aTIM- ACTIVATION SIGNAL SIGNAL PD-1 LAG-3 TCR )ritAG-3 aPD-1 EXHAUSTED T CELL ACTIVATION SIGNAL TCR Ag MHC TIM-3 Ag MHC (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT omit VIII °nolo Holollm olo lionoiliflo oimIE (10) International Publication Number WO 2018/201096 Al (51) International Patent Classification: C07K 16/28 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/US2018/030027 (22) International Filing Date: 27 April 2018 (27.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/491,221 27 April 2017 (27.04.2017) US 62/578,215 27 October 2017 (27.10.2017) US 62/614,998 08 January 2018 (08.01.2018) US 62/625,276 01 February 2018 (01.02.2018) US 62/657,384 13 April 2018 (13.04.2018) US (71) Applicants: TESARO, INC. [US/US]; 1000 Winter Street North, Suite 3300, Waltham, MA 02451 (US). ANAP- TYSBIO, INC. [US/US]; 10421 Pacific Center Court, Suite 200, San Diego, CA 92121 (US). (72) Inventors: JUN, Helen, Toni; c/o Anaptysbio, Inc., 10421 Pacific Center Court, Suite 200, San Diego, CA 92121 (US). KEHRY, Marilyn; c/o Anaptysbio, Inc., 10421 Pacific Center Court, Suite 200, San Diego, CA 92121 (US). BOWERS, Peter; c/o Anaptysbio, Inc., 10421 Pa- cific Center Court, Suite 200, San Diego, CA 92121 (US). KING, David, J.; c/o Anaptysbio, Inc., 10421 Pacific Center Court, Suite 200, San Diego, CA 92121 (US). BOBILEV, Dmitri; c/o Tesaro, Inc., 1000 Winter Street North, Suite 3300, Waltham, MA 02451 (US). GHOSH, Srimoyee; c/o Tesaro, Inc., 1000 Winter Street North, Suite 3300, Waltham, MA 02451 (US). HUANG, Baochuan; c/o Tesaro, Inc., 1000 Winter Street North, Suite 3300, Waltham, MA 02451 (US). JENKINS, David; c/o Tesaro, Inc., 1000 Winter Street North, Suite 3300, Waltham, MA 02451 (US). (74) Agent: ESPINO, Christine, G. et al.; Proskauer Rose LLP, One International Place, Boston, MA 02110 (US). (54) Title: ANTIBODY AGENTS DIRECTED AGAINST LYMPHOCYTE ACTIVATION GENE-3 (LAG-3) AND USES THERE- OF FIGURE 1 1-1 01 O O 1-1 (57) : The disclosure provides antibody agents that bind to a Lymphocyte Activation Gene-3 (LAG-3) protein. Particular immunoglobulin heavy chain polypeptide and immunoglobulin light chain polypeptide sequences are explicitly provided. Also provided 0 are related nucleic acids, vectors, compositions, and methods of using anti-LAG-3 antibody agents to treat a disorder or disease that is \' responsive to LAG-3 inhibition, such as, for example, cancer or an infectious disease. C [Continued on next page] WO 2018/201096 Al MIDEDIMOMOIDEIRDERI00101011M0101101EIMOVOIMIE (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))
ANTIBODY AGENTS DIRECTED AGAINST LYMPHOCYTE ACTIVATION GENE-3 (LAG-3) AND USES THEREOF