Provided is an anti-Pcr V antibody that binds to PcrV and is an antagonist of the Pseudomonas aeruginosa Type III secretion system, comprising: a VH region that comprises a CDR3 having a sequence NRGDIYYDFTYAMDX1, wherein X1 is I, Q, Y or S; a CDR2 sequence VISYDGSEKWYADSVKG; and a CDR1 sequence NYPMH; and a VL region that comprises a CDR3 having a sequence QHFWGTPYT, a CDR2 sequence DASTLQS, and a CDR1 sequence RASEGVDRWLA. The antibody is useful for treating P. aeruginosa infections.
ANTIBODIES TO THE PCRV ANTIGEN OF PSEUDOMONAS AERUGINOSA