The invention relates to pharmaceutical compositions and methods of preparation thereof suitable for the treatment of neurological, affective and psychotic disorders and for the treatment of pain and migraine comprising as an active ingredient an effective amount of 2-hydroxylpropyl valpormide and a pharmaceutically acceptable carrier or diluent. In a broader sense, the invention concerns 2-hydroxylpropyl valpromide (HP-VPD) of the formula:    useful for the treatment of neurological, psychotic and affective disorders, such as convulsions and epilepsy, and for the treatment of pain and migraine.
Active derivatives of valproic acid for the treatment of neurological and psychotic disorders and a method for their preparation