It is intended to provide compounds represented by the following general formula [I]: [I] wherein X represents hydrogen or halogeno; B represents halogeno, cyano or optionally fluorinated lower alkyl; D represents a 3- to 10- membered aliphatic nitrogen-containing heterocycle; R3, R4 and R5 are the sa me or different and each represents hydrogen, optionally substituted lower alky l, etc.; and a is 0 or 1. Because of having a high affinity for nociceptin receptor and thus inhibiting the effect of nociceptin, these compounds are useful as analgesics, antiobestics, brain function-improving drugs, drugs fo r treating Alzheimer~s, drugs for treating dementia, remedies for schizophreni a, remedies for retrograde neurodegenerative diseases, antidepressants, remedie s for diabetes insipidus, remedies for polyuria, remedies for hypotension, etc .
BENZIMIDAZOLE DERIVATIVES