Psychoses in human beings is treated by administering an effective amount of the compound 5-chloro-1-(4-fluorophenyl)-3-(1-(2-(2-imidazolidinon-1-yl)ethyl)-4-piperidyl)-lH-indole, or a pharmaceutically acceptable salt thereof, to a patient in need thereof, the compound selectively blocks dopamine neurones in the ventral teqmental area of the brain, substantially without blocking the dopamine neurones in the substantia niqra pars compacta and, therefore, is free from the extrapyramidal side effects of common neuroleptics.
SELECTIVE BLOCKING OF SPONTANEOUSLY-ACTIVE DOPAMINE NEURONESIN VENTRAL TEGMENTAL AREA