PROBLEM TO BE SOLVED: To provide a method of treating multiple sclerosis, a viral infection, etc.by antagonizing G-CSF, its receptor or their production.SOLUTION: The present invention relates generally to a method for treating, preventing or ameliorating the effects of an inflammatory neurodegenerative condition of the central nervous system (CNS) in a subject, and specifically, multiple sclerosis, Devic's disease or a viral infection, and symptoms and complications arising therefrom. The method comprises administering to the subject a granulocyte colony-stimulating factor (G-CSF) or G-CSF receptor (G-CSFR) inhibiting agent; an antibody specific for G-CSF or G-CSFR, and a 20 to 30 nucleotide sense or antisense molecule targeted to a nucleic acid molecule encoding G-CSF.
TREATMENT OF NEUROLOGICAL CONDITIONS