<P>PROBLEM TO BE SOLVED: To provide methods for treating disorders associated with mGlu receptors by simultaneously inhibiting at least two mGluR belonging to at least two different groups. <P>SOLUTION: There are provided, in one embodiment, methods for treating disorders associated with mGlu receptors 2, 3, and 5, including administering to a subject in need thereof an effective amount of at least one antagonist which modulates mGluR2, mGluR3, and mGluR5. The disorders treated by the method include, for example, nicotine addiction, cocaine addiction, and depression. <P>COPYRIGHT: (C)2010,JPO&INPIT 
mGLU RECEPTOR ANTAGONIST FOR TREATING DISORDER ASSOCIATED WITH mGLU RECEPTOR INCLUDING ADDICTION AND DEPRESSION