FIELD: chemistry.SUBSTANCE: invention relates to novel derivatives of indole and benzoxazine, possessing positive allosteric modulating activity with respect to mGluR2 receptor. In formula (I)Rrepresents Calkyl, substituted with trifluoromethyl, Rrepresents cyano or halogeno, Rrepresents hydrogen, Calkyl, Calkyl, substituted with Ccycloalkyl, pyridinyl, hydroxy Calkyl, CalkyloxyCalkyl, 4-tetrahydropyranyl, 4-(hydroxy)-cyclohexanyl, 4-(hydroxy)-4-(Calkyl)cyclohexanyl, phenyl, pyridinyl methyl, pyridinyl methyl, substituted with one Calkyl group, or phenyl or pyridinyl, substituted with one or two substituents, selected from group, consisting of halogeno and Calkyl, Rrepresents hydrogen or halogeno, A represents radical of formula -CH=CH-(a) or -CH-CH-O-(b), where one or two hydrogen atoms can be substituted with Calkyl. Invention also relates to pharmaceutical composition, containing claimed compounds, and to compound for application in treatment or prevention of central nervous system disorder, selected from the group: anxiety disorders, psychotic disorders, personality disorders, mood disorders, migraine, epilepsy or convulsive disorders, cognitive disorders, attention deficit/hyperactivity syndrome, nervous anorexia, neurogenic bulimia, neurodegeneration, neurotoxicity, ischemia, alcohol addiction, cocaine addiction, nicotine addiction, opioid addiction.EFFECT: obtaining novel indole and benzoxazine derivatives.15 cl, 3 tbl, 6 ex
INDOLE AND BENZOXAZINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS