A method of preventing the headache phase of migraine in a human comprises administration of an anti-convulsant medication to said human exhibiting prodrome symptoms of migraine. Suitably, the method comprises administration of a migraine headache phase-preventing effective amount of the anti- convulsant. There is also disclosed a pharmaceutical composition for the prevention of the headache phase of a migraine containing an anti-convulsant as an active ingredient. There is also disclosed a method of determining prodromal symptoms of migraine using the following cognitive tests: Simple Reaction Time (103); Running Memory Continuous Performance Task (104); Matching to Sample (105); Mathematical Processing Task (106); and interpreti ng the results as a percent of baseline indicator of need for prophylaxis.</SDO AB>
PREEMPTIVE PROPHYLAXIS OF MIGRAINE