Fused tetracyclic benzodiazepines of the formula (I): <IMAGE> (I) where R1 is a cyclic amine such as 1-piperazine and R2 is H or a substituent as defined herein are useful as LHRH antagonizing agents. Also, methods for their synthesis, intermediates used in such synthesis, methods for use as medicaments and pharmaceutical compositions are described.
Method for the treatment of LHRH diseases and conditions