The invention relates to compounds of formulawherein Ris hydrogen, C-alkyl or C-cycloalkyl; Ris hydrogen; Ris hydrogen, C-alkyl, C-alkyl substituted by hydroxy, -(CH)C(O)NH, benzyl, phenyl, -CH-five membered aromatic heterocyclic group selected from an imidazolyl and thiophenyl groups, CH-indolyl, -CH-C-cycloalkyl, C-cycloalkyl or -(CH)-S-C-alkyl; Ris hydrogen or C-alkyl; X is -C(O)-CHR-CHR-C(O)-NH-CH-; R/Rare hydrogen or one of Ror Ris amino; o is 0 or 1; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to a corresponding enantiomer and/or optical isomers thereof. It has been found that the present compounds are oxytocin receptor agonists and can be used for the treatment of autism, stress, anxiety, depression, schizophrenia, psychiatric disorders, memory loss, alcohol withdrawel, drug addiction and Prader-Willi Syndrom.
PEPTIDES AS OXYTOCIN AGONISTS