To provide a method of treatment performed on a subject's brain.SOLUTION: A method includes a step of applying one or more neuromodulation signals to the lateral habenular nucleus and the posterior commissure. The method further includes applying one or more neuromodulation signals to one or more additional targets in the subject's brain. The one or more additional targets include the dorsomedial nucleus of the thalamus. A first neuromodulation signal having a first frequency is applied to the dorsomedial nucleus, and one or more second neuromodulation signals are applied to the lateral habenular nucleus and the posterior commissure, where each of the one or more second neuromodulation signals has a frequency lower than the first frequency.SELECTED DRAWING: Figure 1
METHOD AND DEVICE FOR DEEP BRAIN STIMULATION