The present invention as disclosed provides transoctahydro-oxazolo ¢4,5 g! quinolines of the formula I <IMG> wherein R is H, benzyl, C1-3 straight-chain alkyl or allyl and R1 is J. C1, Br, C1-3 alkyl, O-C1-3 alkyl, OH, NH2, NHC1-3 alkyl and wherein the 4a and 8a hydrogen atoms are in a trans relationship, individual enantioners thereof, and pharmaceutically acceptable salts thereof. These compounds are useful as dopamine D-2 agonists, and thus have utility as prolactin secretion inhibitors and in the treatment of Parkinson's disease, sexual dysfunction, anxiety or depression.
OCTAHYDRO-OXAZOLO (4,5-G)QUINOLINES