The present invention provides a series of non-peptidergic antagonists of NPY comprising piperidine derivatives of 4-phenyl-1,4-dihydropyrimidinones of formula (I), wherein R, R1 and R2 are defined herein. As antagonists of NPYinduced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.
DIHYDROPYRIMIDONE DERIVATIVES AS NPY ANTAGONISTS