The invention relates to an antibody or fragment thereof and a method of treatment and/or diagnosis using the antibody. The antibody or fragment thereof binds to human alpha-synuclein including monomeric, oligomeric and fibril forms of alpha-synuclein; is not cross reactive with beta-synuclein or gamma synuclein; specifically binds human alpha-synuclein and is not cross reactive with rat or mouse alpha-synuclein; binds nitrated, oxidized and phosphorylated forms of alpha-synuclein; and binds an epitope of human alpha synuclein comprising the sequence LEDMPVDPDNEAYE (SEQ ID NO:2). A method for diagnosing a neurodegenerative disease associated with alpha-synuclein or of detecting alpha-synuclein, comprises adding the antibody or fragment thereof to a biological sample from a subject, and detecting the presence or absence of a complex formed between alpha-synuclein and the antibody or fragment.
Alpha-Synuclein Antibodies (11D12)