The subject matter discussed herein relates to the automatic, real-time registration of pre-operative magnetic resonance imaging (MRI) data to intra-operative ultrasound (US) data (e.g., reconstructedimages or unreconstructed data), such as to facilitate surgical guidance or other interventional procedures. In one such example, brain structures (or other suitable anatomic features or structures)are automatically segmented in pre-operative and intra-operative ultrasound data. Thereafter, anatomic structure (e.g., brain structure) guided registration is applied between pre-operative and intra-operative ultrasound data to account for non-linear deformation of the imaged anatomic structure. MR images that are pre-registered to pre-operative ultrasound images are then given the same nonlinearspatial transformation to align the MR images with intra-operative ultrasound images to provide surgical guidance.
DEFORMABLE REGISTRATION FOR MULTIMODAL IMAGES