In some embodiments, without limitation, the present invention comprises compositions and methods for the investigation and treatment of cancers by directly or indirectly blocking or interfering with the delivery of survival signals in cancer cells via a G protein-coupled receptor, in some embodiments, a 5-oxoETE or 5-HETE receptor. Some embodiments comprise the receptor itself and methods to manipulate, block, or interfere with expression of or activity by or through binding with the receptor, including without limitation, by interference with, inhibition, or prevention of action by metabolites of arachidonate 5 -lipoxygenase, such as 5-HETE and its derivative, 5-oxoETE.
INVESTIGATION AND TREATMENT OF CANCER USING A G-PROTIEN COUPLED EICOSNOID RECEPTOR