A system and method for creating magnetic resonance images are provided. The system applies an RF irradiation during a saturation time period at a reference frequency that saturates a range of selected labile spin species of the subject. The system encodes frequency offsets by applying a gradient G1 at least during the saturation time period. The system applies a plurality of slice selection gradients accompanied by a train of RF pulses during a voxel selection time period and a gradient G3 during an acquisition time period. One or more spin/gradient echo signals having information pertaining to at least one of metabolites and metabolite byproducts is acquired to form a CEST medical imaging data set and the CEST medical imaging data set is reconstructed to form a CEST image of the subject including information about the at least one of metabolites and metabolite byproducts within the subject.
System and method for superfast chemical exchange saturation transfer spectral imaging