The present disclosure relates generally to models and methods to modulate neuronal network activities simulating normal brain functions or neurological disorders in culture by applying alternating electric field. The electric field has alternating polarity and changing frequencies to achieve neuronal synchrony. The present disclosure also provides method of modulating modulate directed growth of neuronal axon by applying an alternating field electrical signal. The present disclosure also provides methods of screening compounds using the disclosed models, kits and systems thereof.
Neuronal stimulation model, device and methods using alternate current