PSYCHOGERIATRIC DIAZINYLPIPERIDINE DERIVATIVES OF CYCLIC AMIDES AND IMIDES A series of nootropic compounds of Formula I <IMG> I wherein X is an ethylene chain or a 1,2-benzo ring; Y is carbonyl or methylene; R1 is hydrogen or lower alkyl; and z is an R2, R3-disubstituted diazinyl ring selected from pyridazine, pyrimidine, and pyrazine ring systems. Pharmacological testing demonstrates that the series possesses ability to reverse ECS-induced amnesia in a step-down passive avoidance response test. These pharmacological test results indicate that compounds of Formula I possess cognition and memory enhancing activity.
PSYCHOGERIATRIC DIAZINYLPIPERIDINE DERIVATIVES OF CYCLIC AMIDES AND IMIDES