The invention provides a biomarker for early diagnosis of sporadic amyotrophic lateral sclerosis and Parkinson's disease and application thereof, relates to the technical field of biomedicine, and solves the technical problem that in the prior art, a biomarker cannot play an effective auxiliary diagnosis role in early clinical diagnosis of sporadic ALS and PD diseases. The biomarker is lncRNAs, and a transcript of the lncRNAs includes one or more of lnc-CNTN4-2: 1, lnc-NR3C2-8: 1, lnc-ABCA12-3: 1, lnc-DYRK2-7: 1 and lnc-POTEM-4: 7. By detecting the expression level of one or more of lnc-CNTN4-2: 1, lnc-NR3C2-8: 1, lnc-ABCA12-3: 1, lnc-DYRK2-7: 1 and lnc-POTEM-4: 7, the detected results can be used as an effective method for early diagnosis of whether a patient has a high risk of suffering from sporadic amyotrophic lateral sclerosis and Parkinson's disease or not, and provides possibility for combined diagnosis of a plurality of biomarkers in the future.
Biomarker for early diagnosis of sporadic amyotrophic lateral sclerosis and Parkinson's disease and application thereof