Discloses a bispecific antibody that binds two different regions of low density lipoprotein receptor-related protein 6 (LRP6), wherein the antibody comprises a first VH domain comprising: HVR-H1 of YYYIS; HVR-H2 of EISPYSGSTYYADSVKG; HVR-H3 of RARPPIRLHPRGSV; a first VL domain comprising: HVR-L1 of RASQDVSTAVA; HVR-L2 of SASFLYS; HVR-L3 of QQSYTTPPT; a second VH domain comprising: HVR-H1 of NSYIH; HVR-H2 of WITPYGGYTNYADSVKG; HVR-H3 of GSGHVNAVKNYGYV; and a second VL domain comprising: HVR-L1 of RASQDVSTAVA; HVR-L2 of SASFLYS; and HVR-L3 of QQSYTTPPT. Further discloses related nucleic acids, immunoconjugates and therapeutic uses.
Anti-lrp6 antibodies