PROBLEM TO BE SOLVED: To provide systems and methods for characterizing topological network perturbations.SOLUTION: In order to determine metrics for nodes in a network model of a biological system, response of a biological system to one or more perturbations is quantified based on measured activity data of a subset of entities in the biological system. Based on the activity data and the network model of the biological system, centrality values representative of relative importance of nodes in the network are derived. The centrality values are used for characterization of topological perturbations in the network, which includes performing sensitivity analysis, visualizing topological effects of a perturbation in the biological system, or deriving a score quantifying response of the biological system to a perturbation such as exposure to a chemical agent.SELECTED DRAWING: Figure 5
SYSTEM AND METHOD FOR CHARACTERIZING TOPOLOGICAL NETWORK PERTURBATION