The invention is directed to the use of at least one CB<SUB>x</SUB> modulator wherein the CB<SUB>x</SUB> modulator is selected from the group consisting of CB<SUB>1</SUB> agonists; CB<SUB>2</SUB> agonists; CB<SUB>2 </SUB>partial agonists; CB<SUB>2</SUB> antagonists; CB<SUB>2</SUB> inverse agonists; and dually acting compounds which are both a CB<SUB>1</SUB> agonist and a CB<SUB>2</SUB> agonist; and mixtures thereof, as K<SUB>ATP</SUB> channel modulator for the prophylaxis, treatment, delayed progression, delayed onset and/or inhibition of a variety of disease conditions including obesity, diabetes mellitus, metabolic syndrome, syndrome X, insulinoma, familial hyperinsulemic hypoglycemia, male pattern baldness, detrusor hyperreactivity, asthma, neuroprotection, epilepsy, analgesia, cardioprotection, angina, cardioplegia, arrhythmia, coronary spasm, peripheral vascular disease, cerebral vasospasm, appetite regulation, neurodegeneration, pain - including neuropathic pain and chronic pain - and impotence in mammals and humans. The invention further relates to methods of treating, preventing, delaying progression of, delaying onset of and/or inhibiting a variety of disease conditions including obesity, diabetes mellitus, metabolic syndrome, syndrome X, insulinoma, familial hyperinsulemic hypoglycemia, male pattern baldness, detrusor hyperreactivity, asthma, neuroprotection, epilepsy, analgesia, cardioprotection, angina, cardioplegia, arrhythmia, coronary spasm, peripheral vascular disease, cerebral vasospasm, appetite regulation, neurodegeneration, pain - including neuropathic pain and chronic pain - and impotence in mammals and humans comprising administering to a subject in need thereof an effective amount of at least one CB<SUB>x</SUB> modulator having K<SUB>ATP</SUB> channel modulating properties.
USE OF CBX CANNABINOID RECEPTOR MODULATORS AS POTASSIUM CHANNEL MODULATORS