The present invention relates to humanized antibodies specific to the protofibrillar form of the beta-amyloid peptide, comprising CDR 1-3 of a heavy chain comprising the sequences of SEQ ID NO: 10, 12 and 14, respectively, and CDR 1-3 of a light chain comprising the sequences of SEQ ID NO: 16, 18 and 20, respectively, CDR 1-3 of a heavy chain comprising the sequences of SEQ ID NO: 10, 12 and 14, respectively, and CDR 1-3 of a light chain comprising the sequences of SEQ ID NO: 32, 18 and 20, respectively, or CDR 1-3 of a heavy chain comprising the sequences of SEQ ID NO: 10, 12 and 30, respectively, and CDR 1-3 of a light chain comprising the sequences of SEQ ID NO: 32, 18 and 20, and which bind to the A-β peptides aggregated in senile plaques and not to the diffuse deposits of A-β peptides; and also to the use of said antibodies in the field of Alzheimer's disease.
HUMANIZED ANTIBODIES SPECIFIC TO THE PROTOFIBRILLAR FORM OF THE BETA-AMYLOID PEPTIDE