Preventives or remedies for diseases caused by endoplasmic reticulum stress (for example, neurodegenerative diseases typified by poyglutamine disease, Alzheimer's disease, Parkinson's disease, prion disease, amyotrophic lateral sclerosis and FTDP-17) which contain chemicals having an effect of inhibiting endoplasmic reticulum stress-induced apoptosis and an ASK1 inhibitory effect (for example, ASK1 dominant negative compounds, ASK1 antisense oligonucleotides, glutathione, S-transferases (Mul-1, etc.), Nef, 14-3-3 protein, thioredoxin), sense oligonucleotides thereof, expression vectors thereof or host cells transformed by these expression vectors.
PREVENTIVES OR REMEDIES FOR ENDOPLASMIC RETICULUM STRESS-ASSOCIATED DISEASES