A method and a system automatically evaluate the volume of penumbra mismatch during an exam. The method includes performing a magnetic resonance (MR) diffusion-weighted imaging of the brain for acquiring native diffusion images of brain slices. A MR perfusion-weighted imaging of the brain is performed for acquiring native perfusion images of the brain slices. For each brain slice, b0 native diffusion image of the brain slice are segmented to create a contour mask. For each brain slice, a necrosis and cerebrospinal fluid mask (hereafter NC mask) is created from an ADC map of the brain slice. The contour mask and the NC mask of a same slice are fused. For each brain slice, all native perfusion images acquired for the slice are aligned with the NC mask obtained for the slice and the NC mask is fused with each native perfusion image for obtaining a perfusion image.
Method for volume evaluation of penumbra mismatch in acute ischemic stroke and system therefor