The invention relates to the novel TNF family ligand trimer-containing antigen binding molecules comprising two different fusion polypeptides that comprise a spacer domain, an antigen binding domain and three ectodomains of a TNF ligand member or fragments thereof, wherein two of the ectodomains are separated from each other by the spacer domain comprising at least 25 amino acids, and the two fusion polypeptides are covalently associated to each other in the spacer domain.
Novel TNF family ligand trimer-containing antigen binding molecules