PROBLEM TO BE SOLVED: To provide a method for personalized therapeutic management of a disease in order to optimize therapy and/or monitor therapeutic efficacy.SOLUTION: A method for personalized therapeutic management comprises measuring an array of one or a plurality of biomarkers at a plurality of time points over a course of therapy using a therapeutic agent to determine a mucosal healing index for selecting therapy, optimizing therapy, reducing toxicity, and/or monitoring efficacy of therapeutic treatment. In certain instances, the therapeutic agent is a TNFa inhibitor for treatment of a TNFa-mediated disease or disorder.SELECTED DRAWING: Figure 24
METHOD OF DISEASE ACTIVITY PROFILING FOR PERSONALIZED THERAPY MANAGEMENT