Presented are an unlabeled three-dimensional molecular image generation method and device using a three-dimensional refractive index image and deep learning. The unlabeled three-dimensional molecular image generation device using a three-dimensional refractive index image and deep learning comprises: a three-dimensional refractive index cell image measurement unit which measures a three-dimensional refractive index image for a cell to be observed; and a three-dimensional refractive index-to-molecular-dyed image conversion unit which inputs a measurement value of the three-dimensional refractive index image to a deep learning algorithm to output a three-dimensional molecular-dyed cell image of the cell.
UNLABELED THREE-DIMENSIONAL MOLECULAR IMAGE GENERATION METHOD AND DEVICE USING THREE-DIMENSIONAL REFRACTIVE INDEX IMAGE AND DEEP LEARNING