PROBLEM TO BE SOLVED: To provide tracers for use in diagnostics.SOLUTION: A phosphodiesterase 1-targeting tracer for use in diagnostic technologies based on γ-radiation detection, particularly, a γ-emitter-labeled tracer for SPECT and a positron emitter-labeled composition for PET are disclosed. The invention also discloses radio-labeled multiple novel scaffolds as PDE1 inhibitors such as substituted pyrazolo-pyrimidin-4-one derivatives, in vivo biomarkers for phosphodiesterase 1 (PDE1), a method for developing new therapies for PDE1-implicated conditions such as pulmonary arterial hypertension (PAH), central nervous system (CNS) and cardiovascular (CV) disorders, as well as detecting and treating methods.SELECTED DRAWING: None
PHOSPHODIESTERASE 1-TARGETING TRACERS AND METHODS