INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 12 July 2018 (12.07.2018) WIP0 1 PCT omit VIII °nolo om olo ioo Imo 1111111 ois (10) International Publication Number WO 2018/127608 Al (51) International Patent Classification: C07K 16/46 (2006.01) C07K 16/28 (2006.01) A61K 47/68 (2017.01) C07K 16/32 (2006.01) (21) International Application Number: PCT/EP2018/050481 (22) International Filing Date: 09 January 2018 (09.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17305022.0 09 January 2017 (09.01.2017) EP (71) Applicant: BIOMUNEX PHARMACEUTICALS [FR/FR]; 113 me de la Tour, 75116 PARIS (FR). (72) Inventors: ZHUKOVSKY, Eugene; 5 avenue Fremiet, 75016 Paris (FR). LEGER, Olivier; 603 Route des Luches, 74800 Saint Sixt (FR). (74) Agent: CABINET BECKER ET ASSOCIES; 25, rue Louis le Grand, 75002 PARIS (FR). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) 00 O N 1-1 1-1 (54) Title: A POLYPEPTIDE LINKER FOR PREPARING MULTISPECIFIC ANTIBODIES (57) : The present invention relates to a mutant polypeptide linker for preparing multispecific antibodies, said multispecific 0 antibodies, and methods for producing said multispecific antibodies.
A POLYPEPTIDE LINKER FOR PREPARING MULTISPECIFIC ANTIBODIES