PROBLEM TO BE SOLVED: To obtain new peptide mimics capable of controlling and regulating the interaction of CCR5 (CC chemokine receptor) with a ligand, useful as an anti-HIV agent, an antiinflammatory agent or the like, and capable of binding to an anti-CCR5 antibody. SOLUTION: This pew peptide mimics are CCR5-like peptide mimics capable of binding to an anti-CCR5 antibody, preferably a polypeptide having an amino acid sequence of the formula FCALDGDFGWLAPAC (F is phenylalanine; C is cysteine, A is alanine, L is leucine; D is aspartic acid, G is glycine; W is tryptophan; P is proline), or the like. The peptide mimics are obtained by screening phage random peptide library by using the anti-CCR5 antibody such as mouse anti-human CCR5 monoclonal antibody (2D7), and isolating the phage clone expressing the peptide mimics. The mimics preferably have no homology to an amino acid sequence of the CCR5.
ANTI-CCR5 ANTIBODY-RECOGNIZING PEPTIDE MIMIC, ITS PRODUCTION AND USE THEREOF