The present invention discloses central nervous system (CNS) active compounds, such as psychotropic agents, having anti-dopaminergic activity and ability to modulate glutamate N-menthyl-D-aspartate (NMDA) receptor activity. Such agents are useful in the treatment of schizophrenia and bipolar depression, and in particular have the ability to alter the negative symptoms of schizophrenia. Such agents are also useful in altering states of other mood disorders such as depression and anxiety, cognitive deficits, movement disorders and drug addiction.
NOVEL PSYCHOTROPIC AGENTS HAVING GLUTAMATE NMDA ACTIVITY