A computer-implemented method and system for modeling the pathophysiology of a human intervertebral disc may comprise an anatomic dataset and a biophysical model disposed in connection with a simulation program. The biophysical model may comprise a plurality of subsystems, including, without limitation, governing equations, constitutive equations, boundary conditions, initial conditions, and parameter values. By altering certain subsystems of the biophysical model, a user may selectively solve for certain pathophysiological metrics using at least one of a plurality of algorithms disposed within the simulation program. Moreover, such selective altering of the subsystems, such as, for instance, the boundary conditions, may allow a user to impose certain conditions on the computer-implemented method system, thereby allowing a user to dispose the intervertebral disc of the model at, for instance, in vivo human conditions, and subsequently initiate simulated degeneration conditions thereto, for the efficient and accurate modeling of such an intervertebral disc.
METHOD AND SYSTEM FOR SIMULATING INTERVERTEBRAL DISC PATHOPHYSIOLOGY