The use of p.V37I mutation of GJB2 gene in preparation of products for diagnosing tardive deafness is provided, wherein the said p.V37I mutation is the exclusive p.V37I mutation. Diagnose Kit useful for diagnosing p.V37I mutation of GJB2 gene related to tardive deafness and uses thereof are also provided. The discovery of the exclusive p.V37I mutation of GJB2 gene establishes the gene screening method based on such molecule marker and the preferable application scope thereof in neonatal screening, and the early-warning time of tardive deafness caused by exclusive p.V37I mutation of GJB2 gene is advanced to neonatal period. The exclusive p.V37I mutation of GJB2 gene is widely applied in the fields of early detection, interference and recovery of genetic susceptible tardive deafness, screening and diagnosis of deafness genes, audition-gene combined screening of tardive deafness and related research fields.
DIAGNOSE KIT USEFUL FOR DIAGNOSING P.V37I MUTATION OF GJB2 GENE RELATED TO TARDIVE DEAFNESS