The present invention encompasses a method for treating or preventing migraines in a mammalian patient in need of such treatment or prevention comprising administering to said patient an NR2B receptor antagonist in an amount that is effective to treat or prevent migraines. The invention also encompasses the combination of an NR2B antagonist with a cyclooxygenase-2 selective inhibitor, a calcitonin gene-related peptide receptor (CGRP) ligan d, a leukotriene receptor antagonist or a 5HT1B/1D agonist for the treatment or prevention of migraines.
NR2B RECEPTOR ANTAGONISTS FOR THE TREATMENT OR PREVENTION OFMIGRAINES