Disclosed herein are system, method, and computer program product embodiments for determining a score for a degree of activation of a biological network. An embodiment constructs a tree graph comprising a root node and a set of child nodes. The root node represents a biological network having a reference node and causal connections among a set of nodes that represent biological entities, biological processes, or other biological networks. Each child node represents a particular node in the biological network and is connected to the root node by a signed, directed edge pointing from the root node to that child node. Each child node also has an associated weight based on one or more paths connecting the child node to the reference node in the biological network. The embodiment further scores the tree graph based on scores assigned to the child nodes and the signs of the singed, directed edges.
Quantitative assessment of biological impact by scoring directed tree graphs of causally inconsistent biological networks