The present patent application discloses, among other things, methods and apparatus for a surface microstructured multielectrode array (MEA) for enabling the auto alignment of living cells on exposed electrodes. In one approach the microstructures are fabricated onto the surface of a multielectrode array and attached to a multi well plate such that the metal electrodes are exposed for the attachment of cells to the surface. The microstructure allows for the living cells to self organize into biologically relevant organ mimics onto the electrodes only, which allows electronic electrophysiology monitoting of their behavior when exposed to, e.g., therapeutic substances.
METHOD AND APPARATUS FOR A SURFACE MICROSTRUCTURED MULTIELECTRODE ARRAY