The invention discloses application of lncRNA-LOC100507195 in mycobacterium tuberculosis negative pulmonary tuberculosis diagnosis. It is found that after MTB is infected with macrophage, consequently LOC100507195 expression is up-regulated. The detection results on the PBMC of 30 mycobacterium tuberculosis negative pulmonary tuberculosis patients show that the expression level of LOC100507195 is remarkably lower than that of a healthy volunteer; LOC100507195 is possibly adopted as an antituberculous protective factor of the macrophage, the expression of LOC100507195 is down-regulated, and consequently the body is likely to be infected with tuberculosis. The receiver operating characteristic curve analysis result shows that LOC100507195 is expected to become a new target spot of mycobacterium tuberculosis negative pulmonary tuberculosis diagnosis. Uninfected people and the mycobacterium tuberculosis negative pulmonary tuberculosis patients can be effectively distinguished by detecting the expression level of LOC100507195.
Application of lncRNA-LOC100507195 in mycobacterium tuberculosis negative pulmonary tuberculosis diagnosis