PROBLEM TO BE SOLVED: To provide: an inhibitor that locks the ectodomain of a human receptor tyrosine kinase in an inactive state thereby antagonizing the activity of the receptor tyrosine kinase; and a method of use thereof.SOLUTION: The present invention provides a moiety that binds to an ectodomain such as an Ig-like domain of human Kit/RTK or PDGFR/RTK, such as D4 or D5 of a human receptor tyrosine kinase or D7 domain of a type V receptor tyrosine kinase.
INHIBITOR OF RECEPTOR TYROSINE KINASE AND METHOD OF USE THEREOF