<P>PROBLEM TO BE SOLVED: To provide a method for preventing and/or delaying or alleviating neurodegenerative diseases such as amyotrophic lateral sclerosis. <P>SOLUTION: Compositions to treat neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) contains pramipexole(2-amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole). Use of such compositions is also provided. As shown Fig.6B (not shown), the mean +/-SEM serum 2,3-DHBA level for 12 ALS patients decreases significantly after pramipexole treatment. <P>COPYRIGHT: (C)2010,JPO&INPIT 
USE OF PRAMIPEXOLE TO TREAT AMYOTROPHIC LATERAL SCLEROSIS