To provide negative or inhibitory CAR for use to generate negative signals suitable for preventing the off-target activation of T cells which results in a positive T cell signal.SOLUTION: The invention provides an inhibitory chimeric antigen receptor comprising an extracellular domain comprising an antigen-binding domain, a transmembrane domain and an intracellular domain, where the intracellular domain comprises an immunoreceptor tyrosine-based switch motif (ITSM), where the ITSM is an amino acid sequence TX1YX2X3X4 in which X1 is an amino acid, X2 is an amino acid, X3 is an amino acid, and X4 is V or I.SELECTED DRAWING: Figure 5-1
INHIBITORY CHIMERIC ANTIGEN RECEPTORS