PROBLEM TO BE SOLVED: To provide a prophylactic, therapeutic and/or symptom-ameliorating agent for patulous eustachian tube, efficacy of which has not been established.SOLUTION: A limaprost family is effective as a prophylactic and/or therapeutic agent for patulous eustachian tube. It is also effective as an ameliorating agent for various symptoms such as accentuation of one's voice, ear fullness, one's respiratory sound-listening, wobble, dizziness, audibility decrease, auditory disturbance, otalgia, tinnitis, stiff neck, stiff shoulder, headache, depressive symptom or the like, which are symptoms of patulous eustachian tube. Further the limaprost family is effective to patients to whom herbal drugs, antianxiety drugs, vitamin preparations and/or ATP preparations are ineffective, which are used in clinical sites.
THERAPEUTIC AGENT FOR PATULOUS EUSTACHIAN TUBE