2-Substituted 4-(omega -nitrato-alkylamino)-pyrimidine-3-N-oxides (I) are new. Pyrimidine derivatives of formula (I) and their salts are new. [Image] n : 2-12; R1optionally unsaturated 1-12 C alkyl (optionally substituted by OR', NR'R'' or COOR') or NR'R''; R2H, NR3R4, OR3 or SR3; R3, R4optionally unsaturated alkyl (optionally substituted by OR', NR'R'' or COOR'); or NR3R44-7 membered saturated or unsaturated heterocycle, optionally containing at least one further heteroatom; and R', R'' : H or 1-3C alkyl. An independent claim is included for the preparation of (I). ACTIVITY : Antialopecia; Dermatological; Anorectic; Antiulcer; Vasotropic; Antipsoriatic; Antimycotic; Antiinflammatory; Antiallergic; Antipruritic; Vulnerary. MECHANISM OF ACTION : Lysyl hydroxylase (LH) inhibitor; nitrogen monoxide (NO) precursor. In tests for modulation of inducible NO synthase induction in normal human keratinocytes (as a measure of NO donor activity) cultures, 2-amino-4-(3-nitrato-propylamino)-pyrimidine-3-N-oxide (Ia) caused a degree of inhibition of 296.17% at a concentration of 1000 MicroM.
Hair composition containing a pyrimidine-n-oxide derivative and its use to stimulate keratinic fiberes growth and/or preventing their loss