Provided is a method of diagnosing multiple sclerosis in a subject, the method comprising detecting an anti-Glc (alpha 1-4) Glc (alpha) antibody in a test sample obtained from a subject; and comparing the levels of said antibody in said test sample to a control sample, wherein said control sample is selected from one or more individuals that have multiple sclerosis symptoms and have a known multiple sclerosis status, and one or more individuals that do not show multiple sclerosis symptoms, thereby diagnosing multiple sclerosis in said subject. 
Elevated serum levels of auto antibodies to IgG, IgA and IgM that bind to glycan structures used in a diagnostic test for MS