The present invention proposes a gene network construction apparatus and method for constructing an Alzheimer's disease (AD)-specific gene network by selecting gene pairs from among gene samples on the basis of mutual information amounts of genes and extracting sub-networks associated with AD from the gene pairs. The apparatus according to the present invention comprises: a gene pair selection unit for selecting first gene pairs associated with AD from among predetermined gene samples on the basis of a first mutual information amount of genes associated with people without having AD and a second mutual information amount of genes associated with people having AD; a gene pair integration unit for integrating the first gene pairs by using a node property on the basis of information on a pathway of each gene pair; a sub-network extraction unit for extracting sub-networks associated with AD on the basis of a seed-based search method when the first gene pairs are integrated; and a gene network construction unit for constructing the AD-specific gene network on the basis of the sub-networks associated with AD.
GENE NETWORK CONSTRUCTION APPARATUS AND METHOD