The present invention encompasses compounds of formula (I) and the phamaceutically acceptable non-toxic salts thereof wherein ( alpha ) represents (a); (b); (c); (d); X is oxygen or sulfur; W is phenyl, thienyl, or pyridyl, each of which may be unsubstituted or mono or disubstituted with organic or inorganic substituents; A, B, C and D represent carbon or nitrogen, each of which may be substituted with various organic or inorganic groups; E is oxygen, sulfur, or substituted or unsubstituted nitrogen; and R3 and R4 are the same or different and represent various organic or inorganic substituents; which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine drugs, and enhancement of memory structures.
CERTAIN ARYL FUSED IMIDAZOPYRIMIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS