A drug combination therapy useful in the treatment of dementia associated wi th disorders of the central nervous system, e.g. to delay the onset or progression of Alzheimer~s disease, cerebrovascular disease or Down~s syndrome, comprises a combination of a 1-aminocyclohexane derivative such as memantine or neramexane and an acetylcholinesterase inhibitor such as galantamine, tacrine, donepezil or rivastigmine.
COMBINATION THERAPY USING 1-AMINOCYCLOHEXANE DERIVATIVES ANDACETYLCHOLINESTERASE INHIBITORS