MONOCLONAL ANTIBODIES INVOLVED IN ALZHEIMER'S DISEASE HYBRIDOMAS SECRETING THESE MONOCLONAL ANTIBODIES, ANTIGEN RECOGNIZED BY THESE ANTIBODIES, AND THEIR APPLICATION The invention relates to a monoclonal antibody characterized by the combination of the following properties : - it forms an immunological complex with a nonphosphorylated structural epitope of an antigen released from a sonicated NFT preparation, which itself is isolated from the cerebral cortex obtained from a patient having Alzheimer's disease, - it does not form an immunologically complex with the following proteins or peptides : . neurofilament proteins . tau protein . MAP 2 protein . ubiquitin . 4-amyloid peptide, said monoclonal antibody can be used for the diagnosis in vitro of brain diseases involving neurofibrillary degeneration.
MONOCLONAL ANTIBODIES INVOLVED IN ALZHEIMER'S DISEASE, HYBRIDOMAS SECRETING THESE MONOCLONAL ANTIBODIES, ANTIGEN RECOGNIZED BY THESE ANTIBODIES, AND THEIR APPLICATION