The invention discloses a novel coronavirus animal model and application. After the animal model is infected with MHV and SARS-CoV-2, the immune response of the lung of the animal model is remarkablyenhanced in antibacterial immune response, abnormal proliferation of immature central granulocytes can be caused, and the result is consistent with the result of abnormal proliferation of immature neutrophils in severe patients. The hyperplasia phenomenon is a unique characteristic caused by coronavirus infection, and can be used as an important evaluation index of coronavirus infection degree anddisease progression degree. The animal model disclosed by the invention is an effective model for evaluating a novel coronavirus pneumonia pathological state and a drug by using a small molecule drug.
Novel coronavirus animal model and application