The present invention relates to a method for evaluating synaptic dysfunction using brain tissue clearing, and a method for evaluating synaptic dysfunction, according to the present invention, comprises a step of making brain tissue transparent, wherein a clear three-dimensional image of a neuron may be obtained by making the brain tissue transparent, and synaptic dysfunction may be evaluated by effectively analyzing and quantifying the length and distribution of spines of the neuron through the Imaris program. In addition, the method of the present invention for evaluating synaptic dysfunction is expected to be useful for preventing neurological disorders and screening a drug for treatment by analyzing the length and distribution of spines of a neuron according to processing of the drug in animal models of a neurological disorder.
METHOD FOR EVALUATING SYNAPTIC DYSFUNCTION USING BRAIN TISSUE CLEARING