A method for treating depression in a subject in need thereof is provided. The method includes treating the subject by seizure therapy administered through electroconvulsive therapy (ECT) or magnetic seizure therapy (MST). The method further includes evaluating change in complexity of temporal dynamics in the brain of the subject, following treatment, to identify whether complexity of fine time scale temporal dynamics in the fronto-central and/or parieto-occipital region is reduced following treatment. The reduced complexity of fine time scale temporal dynamics in the fronto-central and/or parieto-occipital region following treatment identifies the subject as a responder to the seizure therapy for treating depression. The step of evaluating further comprises identifying change in complexity of coarse scale temporal dynamics in a parieto-central region following treatment.
Methods of using brain temporal dynamics