The present invention relates to compounds of furmula (I),wherein A is an optionally substituted phenyl, naphthyl, pyridyl,pyrazinyl, pyridazinyl, pyrimidyl, thienyl, thiazolyl, oxazolyl,thiadiazolyl having at least two adjacent ring carbon atoms or abicyclic ring system, provided that the -CH(R3)N(R2 )B-R1 and-OCH(R4-)-D linking groups are positioned in a 1,2 relationship toone another on ring carbon atoms and the ring atom positionedortho to the -OCHR4 - linking group (and therefore in the3-position relative to the -CHR3NR2- linking group) is notsubstituted; B is an optionally substituted ring system; D is anoptionally substituted ring system; R1 is a variety of group asdefined in the description; R2 is hydrogen, C1-6alkyl,C2-6alkenyl, C2-6alkynyl, phenylC1-3alkyl or 5- or 6-memberedheteroarylC1-3alkyl; R3 is hydrogen or C1-4alkyl; R4 is hydrogenor C1-4alkyl; and N-oxides of NR2 where chemically possible; andS-oxides of sulphur containing rings were chemically possible; andpharmaceutically acceptable salts and in vivo hydrolysable estersand amides thereof. Process for their preparation, intermediatesin their preparation, their use as therapeutic agents andpharmaceutical compositions containing them.18 claims
AROMATIC AMINO ETHERS AS PAIN RELIEVING AGENTS