PROBLEM TO BE SOLVED: To provide neurokinin-1 (NK-I) receptor antagonists, and inhibitors of tachykinin and in particular substance P, used in the treatment of emesis, urinary incontinence, LUTS, depression, and anxiety.SOLUTION: The present invention is directed to certain hydroxymethyl ether hydroisoindoline compounds of Formula (I).
HYDROXYMETHYL ETHER HYDROISOINDOLINE TACHYKININ RECEPTOR ANTAGONIST