It is found out that the overexpression of a secretory anti-adhesion factor SPARC (secreted protein acidic and rich in cysteine) in the GABA inhibiting nerve in the hippocampal radial layer region would induce epileptic symptoms. Thus, an animal model for epilepsy is constructed by using this secretory anti-adhesion factor. This transformant animal model is highly useful in developing a novel drug or a preventive method for epilepsy relating to GABA inhibiting nerve functions.
NOVEL ANIMAL MODEL FOR EPILEPSY