A compound of formula I wherein values of R1 and X are defined in the claims; said compound is 1 (NK-1) neurokinins receptor antagonist, inhibitors of tachykinin and in particular substance P. The pharmaceutical compo¬sitions containing them are useful for treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
HYDROISOINDOLINE TACHYKININ RECEPTOR ANTAGONISTS