INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WIPO I PCT oimiolo VIII °nolo VIII ioo no Elul° oimIE (10) International Publication Number WO 2018/160055 Al (51) International Patent Classification: A61K 31/192 (2006.01) A61P 25/28 (2006.01) A61K 31/196 (2006.01) A61P 43/00 (2006.01) A61P 25/18 (2006.01) (21) International Application Number: PCT/MY2018/000001 (22) International Filing Date: 04 January 2018 (04.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/466,749 03 March 2017 (03.03.2017) US (71) Applicants: EXCELSIOR PHARMATECH LABS [CN/CN]; 14F-7, No. 3, Park St., Nangang Dist., Taipei, Taiwan 11503 (CN). YING-TUNG, Lee [MY/MY]; 8, Jalan Bukit Permai 1/3, Taman Bukit Permai, Bandar Sun- gai Long, Selangor, 43000 (MY). (72) Inventor; and (71) Applicant: HSIEN-YUAN, Lane [CN/CN]; 12F-5, No.360, Jianxing Rd., North Dist., Taichung, 404 (TW). (72) Inventor: PIN-CHEN, Yang; No. 100, Tzyou 1st Road, Kaohsiung, 807 (TW). (74) Agent: JUSTIN, Anandan Santiago; Nanyang IP Sdn Bhd, 30-3, Jalan Bangsar Utama 1, Bangsar, Kuala Lumpur, 59000 (MY). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: of inventorship (Rule 4.17(iv)) as to non prejudicial disclosures or exceptions to lack of novelty (Rule 4.17(v)) Published: with international search report (Art. 21(3)) O O (54) Title: METHOD FOR PREVENTING OR TREATING AUTISM SPECTRUM DISORDERS BY BENZOIC ACID SALT 00 (57) : The present disclosure provides a method for preventing or treating an autism spectrum disorder in a subject in need O thereof. The method includes administering to the subject a composition containing a therapeutically effective amount of a benzoic acid salt and a pharmaceutically acceptable excipient thereof. Also provided is a composition for use in preventing or treating an autism C spectrum disorder in a subject in need thereof.
METHOD FOR PREVENTING OR TREATING AUTISM SPECTRUM DISORDERS BY BENZOIC ACID SALT