NRC 49.1160100.4i . l aitib 02 -it- Mil 102 10.3 104 104 10 10-7 o 0 4 0.0 10 NR (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 September 2018 (27.09.2018) WIP0 I PCT o mum °nolo UI n ono oimIE (10) International Publication Number WO 2018/175833 Al (51) International Patent Classification: A61K 39/395 (2006.01) C07K 16/18 (2006.01) A61K 39/00 (2006.01) C07K 16/28 (2006.01) A61K 45/06 (2006.01) C07K 14/00 (2006.01) (21) International Application Number: PCT/US2018/023927 (22) International Filing Date: 23 March 2018 (23.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/475,573 23 March 2017 (23.03.2017) US (71) Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; 3160 Chestnut Street, Suite 200, Philadelphia, PA 19104 (US). (72) Inventors: SONG, Wenchao; 213 Cornell Drive, Bryn Mawr, PA 19010 (US). MIWA, Takashi; 191 Presiden- tial Blvd., Unit 323, Bala Cynwyd, PA 19004 (US). SA- TO, Sayaka; 2130 Locust Street, Apt. #A1, Philadelphia, PA 19103 (US). GULLIPALLI, Damodar; 4007 Wood- land Avenue, Apt. B, Philadelphia, PA 19106 (US). (74) Agent: HAAS, Dennis, L. et al.; Riverside Law, LLP, Glenhardie Corporate Center, 1285 Drummers Lane, Suite 202, Wayne, PA 19087 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: ANTI-05A ANTIBODIES AND USES THEREOF 7Al2 Control anti-05 mAb 00 Figure 1 N 1-1 1-1 (57) : This invention relates to inhibition of the complement signaling using anti-05a antibody. Specifically, the invention © relates to methods of treating a complement-mediated disease or complement-mediated disorder in an individual by contacting the C individual with an anti-05a antibody. [Continued on next page] WO 2018/175833 Al MIDE111111011111 1111E111E31111111111111111111111111111111101111111111 Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))
ANTI-C5A ANTIBODIES AND USES THEREOF