C:\Interoven\NRPortbl\DCC\FMT\17629114_l.doex-30/08/2018 The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides. WO 2014/093908 PCT/US2013/075157 Fig.1I 8 IgH BACs (550 kb) AV0& (\-\{) N'' Xv1,\t' ,K Al'<) xW A 4, 4 ' 4'F4 \ 4 bg&BACs(v300 kb) N! N'N N' k 'IN ' j4<i 0' K 0Q4N K 4o CigYAC(1300 kb) 1\/IV' v ~ \~l<~ \V\~v''K2< No< \& K~c\ %\%s~\i0
Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same