The acetylcholinesterase 14-mer peptide AEFHRWSSYMVHWK acts alone or in synergism with <SUP>2</SUP>-amyloid to contribute to neuronal degeneration, e.g. in Parkinson's and Alzheimer's diseases, perhaps by exerting calcium channel opening activity. Antibodies and other compounds which inhibit the biological activity are useful for prophylaxis or treatment.
Peptide from soluble form of acetylcholinesterase, active as a calcium channel modulator