To provide an Anti-Repulsive Guidance Molecule a (RGMa) antibody that can be used as a medicine for the prevention, treatment or recurrence prevention of neurological or immunological diseases, has high binding activity, and has few side effects.SOLUTION: Provided is an isolated RGMa binding protein that does not inhibit the binding of RGMa and Neogenin and neutralizes neurite outgrowth inhibitory activity of RGMa, preferably, an anti-RGMa antibody in which the amino acid sequence of a complementarity determining region is RASQDISSYLN, YTSRLHS, QQLNTLP, DAWMD, EIRSKANNHATYYAESVKG, RDGAY or RSSQSLVHSNGNTYLH, KVSNRFS, SQSTHVP, TSYYWN, YISYDGTNNYNPSLKN, and SFG.SELECTED DRAWING: Figure 5
RGMa BINDING PROTEIN AND USE THEREOF