To provide antibodies and antigen-binding portions thereof that bind to FcRn and their use for modulating or inhibiting interaction of FcRn with antibody Fc regions.SOLUTION: Provided herein are recombinant antibodies and antigen-binding portions thereof useful for binding to FcRn and blocking binding of FcRn to IgG Fc. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.SELECTED DRAWING: Figure 1
HUMANIZED AFFINITY MATURED ANTI-FcRn ANTIBODIES