RAN 4008/347 The known compounds of the general formula I wherein A together with the two carbon atoms denoted by .alpha. and .beta. signifies the group (a) (b) or (c), R1 signifies halogen, cyano, lower alkyl. lower 1-alkenyl, lower alkoxymethyl or the group -COOR6 or -C?C-R7, R2 signifies hydrogen and R3 signifies lower alkyl or R2 and R3 together signify dimethylene or trimethylene, R4 and R5 each signify hydrogen, halogen, trifluoromethyl or lower alkyl, R6 signifies lower alkyl, C3-C7-cyclo-alkyl or C3-7-cycloalkyl-lower alkyl and R7 signifies hydrogen, lower alkyl, lower hydroxyalkyl. lower alkoxyalkyl, C3-7-cycloalkyl-lower alkyl, C3-7-cycloalkyl-lower hydroxyalkyl, C3-7-cyclo-alkyl-lower alkoxyalkyl, (C3-7-cycloalkyl-lower alkoxy)-lowec alkyl, (aryl-lower alkoxy)-lower alkyl, lower alkanoyloxy-lower alkyl, (C3-7-cycloalkyl- -lower alkanoyloxy)-lower alkyl, C3-7-cycloalkyl-carbonyloxy-lower alkyl, (aryl-lower alkanoyloxy) -lower alkyl, arylcarbonyloxy-lower alkyl, lower alkenyl, lower hydroxyalkenyl, lower alkoxy-lower alkenyl, (C3-7-cycloalkyl-lower alkoxy)-lower alkenyl, (aryl-lower alkoxy)-lower alkenyl, lower alkanoyloxy-lower alkenyl, (C3-7-cycloalkyl-lower alkanoyloxy)-lower alkenyl, C3-7-cycloalkylcarbonyl-oxy-lower alkenyl, (aryl-lower alkanoyloxy)-lower alkenyl, arylcarbonyloxy-lower alkenyl, C3-7-cyclo-alkyl, hydroxy-C4-7-cycloalkyl or lower alkoxy -C4-7-cycloalkyl, the compounds of formula I having the (S)- or (R,S)-configuration with respect to the carbon atom denoted by .gamma. when R2 and R3 together signify dimethylene or trimethylene, can be used in the treatment of neurological symptoms which are associated with circulatory disorders of the brain, especially in the treatment of neurological symptoms which are associated with cerebrovascular seizures.
IMIDAZODIAZEPINES FOR THE TREATMENT OF NEUROLOGICAL SYMPTOMS