PROBLEM TO BE SOLVED: To provide methods of, and compositions for, treating central nervous system injury with an antagonist of an α4 subunit containing an integrin.SOLUTION: The invention relates generally to methods of treatment for acute Central Nervous System (CNS) injury. In particular, the invention relates to the use of antagonists of α4 integrins to treat CNS damage resulting from traumatic brain injury, spinal cord injury or stroke, including ischemic and hemorrhagic injuries. The α4 integrin antagonist chosen can be used as a sole therapeutic agent or in combination with other pharmaceutical regents.
METHOD OF TREATING CENTRAL NERVOUS SYSTEM ISCHEMIC OR HEMORRHAGIC INJURY USING ANTI α4 INTEGRIN ANTAGONIST