WO 18/07 167 6 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 April 2018 (19.04.2018) WIP0 1 PCT omit VIII °nolo mom VIII ioo mom° oimIE (10) International Publication Number WO 2018/071676 Al (51) International Patent Classification: A01N 1/02 (2006.01) A61K 39/395 (2006.01) A61B 5/055 (2006.01) (21) International Application Number: PCT/US2017/056349 (22) International Filing Date: 12 October 2017 (12.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/407,390 12 October 2016 (12.10.2016) US (71) Applicant: BIOVERATIV USA INC. [US/US]; 951 Gate- way Blvd., South San Francisco, CA 94080 (US). (72) Inventors: PANICKER, Sandip; 951 Gateway Boulevard, South San Francisco, CA 94080 (US). PARRY, Graham; 951 Gateway Boulevard, South San Francisco, CA 94080 (US). STAGLIANO, Nancy, E.; 951 Gateway Boulevard, South San Francisco, CA 94080 (US). (74) Agent: KIM, Ji-Eun et al.; Sterne, Kessler, Goldstein & Fox P.L.L.C., 1100 New York Avenue, NW, Washington, DC 20005 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (54) Title: ANTI-C1S ANTIBODIES AND METHODS OF USE THEREOF (57) : The present disclosure provides antibodies that specifically bind complement pathway component Cls. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the anti-Cls antibodies; and host cells comprising the nu- cleic acids. The present disclosure provides compositions comprising the anti-Cls antibodies. The present disclosure provides methods of use of the anti-Cls antibodies.
ANTI-C1S ANTIBODIES AND METHODS OF USE THEREOF