The absorption of orally administered substantially aqueous insoluble psychoactive 2-aryl-pyrazolo [4,3-C] quinolin-3-ones of the formula <CHEM> wherein R sec is hydrogen, lower alkyl, lower alkoxy, hydroxy, halo or trifluoromethyl, and R min is hydrogen, lower alkyl, lower alkoxy, hydroxy, halo, trifluoromethyl, nitro, amino, mono- or di-lower alkylamino, mono- or di-lower alkylcarbamoylamino, mono- or di-lower alkylcarbamoyloxy or cyano, or a pharmaceutically acceptable salt thereof, is enhanced by administering the same in the form of a storage stable solid molecular dispersion of polyvinylpyrrolidone.
Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone.