The present invention relates to a composition for the prevention and treatment of anxiety disorder containing a T-type calcium channel blocker, and a method for the prevention and treatment of anxiety disorder by administering the said composition into mediodorsal thalamus (MD) of a subject with anxiety disorder. When the T-type calcium channel blocker mibefradil is administered into MD of the phospholipaseß4 (PLCß4, expressed mainly in MD) knock-out mouse, fear memory extinction which has been reduced is restored to normal level. When mibefradil and efonidipine are administered into MD of the wild type mouse, fear memory is lost faster than usual and fear memory recall is retarded. Therefore, a T-type calcium channel blocker can be effectively used for the prevention and treatment of anxiety disorder.
METHOD FOR TREATMENT OF ANXIETY DISORDER BY REGULATING T-TYPE CALCIUM CHANNEL