Disclosed are methods, kits, and devices for diagnosing and treating psychiatric disorders and the symptoms thereof. The methods, kits, and devices relate to identifying genetic markers that may be utilized to diagnose and/or prognose a subject and treat the diagnosed and/or prognosed subject by administering a drug the subject based on the genetic marker having been identified. Genetic markers identified in the methods may include a polymorphism in a gene encoding a protein associated with synaptogenic adhesion, scaffolding, neuron-specific splicing regulation, potassium channels which form leak conductances that regulate neuronal excitability, synaptic spine turnover and stability of synaptic contacts, and/or vesicle trafficking and exocytosis in presynaptic neurons and neuromuscular junctions. The disclosed methods, kits, and devices have implications for developing new antipsychotic drugs that target the activity of proteins associated with the identified genetic markers and for diagnosing/prognosing a response to an antipsychotic drug based on the genetic markers.
POLYMORPHISMS FOR PREDICTING TREATMENT RESPONSE TO ANTIPSYCHOTIC DRUGS AND IDENFYING NEW DRUG TARGETS