The present disclosure provides methods of imaging neurotransmitters and metabolites present in a biological sample comprising: pneumatically spraying or having sprayed the biological sample with a nanoparticle, introducing the sample to a laser desorption ionization mass spectrometer to collect mass spectral data and identifying the neurotransmitters or metabolites in the sample based on the mass spectral data.
METHODS FOR LASER DESORPTION IONIZATION MASS SPECTROSCOPY BASED IMAGING OF NEUROTRANSMITTERS AND METABOLITES USING NANOPARTICLES