A compound of formula (I) including stereoisomers and pharmaceutically acceptable salts thereof. Compounds of formula (I) have utility in the treatment of disorders manifesting hyper-secretion of CRF in warm blooded animals, such as stroke, depression, anxiety disorder, panic disorder, obsessive-compulsive disorder, abnormal aggression, unstable angina, reactive hypertension, anorexia nervosa, bulimia, irritable bowel syndrome, stress-induced immune suppression, inflammation, Cushing's disease, substance abuse or withdrawal, infantile spasms, epilepsy or inflammatory bowel disease.
Tricyclic heterocyclic CRF receptor antagonists and their use in treatment