PROBLEM TO BE SOLVED: To provide: methods of treatment and diagnosis using NRG-2 polypeptides, nucleic acid molecules and antibodies; and novel NRG-2 polypeptides and nucleic acid molecules.SOLUTION: A full-length cDNA encoding NRG-2α has been identified from cerebellum. Multiple probes to various regions of NRG-2 coding sequences have been designed based on rodent and human sequence data for cloning, mapping and sequence analysis. Prior to screening libraries, the specificity of the probes has been confirmed by analyzing human cerebellar RNA using a 3'RACE (rapid amplification of cDNA ends) approach.SELECTED DRAWING: None
NRG-2 NUCLEIC ACID MOLECULES, POLYPEPTIDES, AND DIAGNOSTIC AND THERAPEUTIC METHODS