PROBLEM TO BE SOLVED: To provide methods for treating subjects suffering from epilepsy.SOLUTION: The invention provides an epilepsy treating agent comprising a PSD-95 inhibitor that inhibits binding of PDZ binding ligand to PDZ domain of PSD-95. The inhibitor is a chimeric peptide comprising an active peptide linked to an internalizing peptide where the active peptide has an amino acid sequence consisting of 3-25 amino acids from the C terminus of an NMDA receptor or a PDZ domain 1 and/or 2 from a PSD-95 receptor. The inhibitor is Tat-NR2B9c or F-Tat-NR2B9c of the following structure. As shown in FIG.4A, Tat-NR2B9c is neuroprotective in the anterior CA1 region of the hippocampus.SELECTED DRAWING: Figure 4A
TREATMENT FOR EPILEPSY