Described herein is a method to induce surface trafficking of the delta-Opioid Receptor (DOR) and its applications, including, leveraging the antinociceptive potential of DOR agonists to treaty neurologic disorders and to be analgesics without the adverse consequences normally associated with chronic treatment by MOR agonists by inducing surface trafficking of the delta-Opioid Receptor (DOR) and screening compounds to identify additional targets for stimulated DOR delivery.
Method to increase bioavailability of the delta-opioid receptor for management of pain and neuropsychiatric disorders