<P>PROBLEM TO BE SOLVED: To examine by comparing neuromuscular transmission inhibitory activity and treatment index of an M-form with a mixture of an L-form and LL-form of type A botulinus toxin. <P>SOLUTION: The M-form of the type A botulinus toxin has characteristics such as (1) excellent in the neuromuscular transmission inhibitory activity, (2) having a high treatment index, (3) having a low antigenicity, and (4) without attenuating its effect by repeated administration as compared with those of the mixture of its L-form and LL-form, and therefore especially useful as a treating agent of diseases caused by hypertonia such as strabismus, blepharospasm, one-sided facial spasm, spastic torticollis, paralysis after stroke, infantile cerebral palsy, spastic aphonia, head ache, lumbago, neck pain, back pain, stiff shoulder, muscular relaxation failure occurring on getting Parkinsonian disease or multiple sclerosis, fascia pain syndrome, spasm of mastication muscle, chronic anal fissure, urinary incontinence, bruxism, facial myokymia, tic, local dystonia, wrinkles, etc. <P>COPYRIGHT: (C)2005,JPO&NCIPI 
TREATING AGENT OF HYPERTONIC DISEASE