Provided are a human anti-a9 integrin antibody or antibody fragment which specifically recognizes human a9 integrin and mouse a9 integrin and inhibits an interaction with a ligand therefor, particularly the antibody or antibody fragment which recognizes loop regions of human and mouse a9 integrins, a gene encoding the antibody or antibody fragment, a recombinant expression vector containing the gene, a transformant transfected with the gene, a method for producing a human anti-a9 integrin antibody or antibody fragment using the transformant, and a preventive or therapeutic agent for rheumatoid arthritis containing the antibody or antibody fragment.
HUMAN ANTI-?9 INTEGRIN ANTIBODY