<P>PROBLEM TO BE SOLVED: To provide broad-spectrum antibiotics that are inhibitors of bacterial adenine DNA methyltransferases. <P>SOLUTION: A pharmacetical composition comprises a compound of di-(p-fluorophenyl)borinic acid 8-hydroxyquinoline ester, di-(p-chlorophenyl)borinic acid 8-hydroxyquinoline ester, diphenylborinic acid 8-hydroxyquinoline ester, di-(p-fluorophenyl)borinic acid 8-ethanolamine ester, di-(p-chlorophenyl)borinic acid 8-ethanolamine ester, N4-[2-(diphenylboryloxy)ethyl]pyrimidine-4,6-diamine, or N-[2-(diphenylboryloxy)ethyl]-1H-imidasol-4-carboxamidine. <P>COPYRIGHT: (C)2008,JPO&INPIT 
DNA METHYL TRANSFERASE INHIBITOR