The present invention relates to a method of diagnosing and further determining the course of the disease in an individual with adult Still's disease. The method includes the following steps: (a) providing a blood sample and peripheral blood mononuclear cells; (b) detecting the expression level of the protein biomarker IL-18 in the blood sample; (c) detecting the expression of long-chain non-coding RNA biomarkers MIAT or THRIL in the peripheral blood mononuclear cells; (d) calculating the A-score by using the predicted function obtained by multiple regression analysis with the expression levels of IL-18, MIAT and THRIL detected in steps (b) and (c); (d) calculating the A-score by using the predicted function obtained by multiple regression analysis with the expression levels of IL-18, MIAT and THRIL detected in steps (b) and (c); and (e) comparing the A-score calculated in step (d) with a critical value, obtained by the receiver operating characteristic curve method, corresponding to the area under the ROC curve reaching a maximum, the A-score above the critical value value indicates that the individual suffers from adult Still's disease. The sequence of step (b) and step (c) can be reversed, which does not affect the judgment of the embodiment of the present invention and the final result.
Methods of diagnosing and typing adult Still's disease