NMDA receptor antagonists can be used in methods of treatment, for reducing the frequency of stereotypic behaviors in animals and for reducing the frequency of analogous compulsive behaviors in humans, for example, those that have been said to be a manifestation of, or related to, obsessive-compulsive disorder. Of particular interest is the non-competitive NMDA receptor antagonist memantine.
Treatment of stereotypic, self-injurious and compulsive behaviors in man and animals using antagonists of NMDA receptors