Discloses a B7-H3 antibody which comprises three heavy and three light chain CDR’s and that specifically binds to an extracellular domain of B7-H3, wherein said molecule (A) binds to 4Ig and 2Ig isoforms of B7-H3 that is endogenously expressed on the surface of a cancer cell; (B) is internalized upon binding to B7-H3 expressed on the surface of the cancer cell; and (C) comprises a variable domain that comprises the CDR sequences of RASQDISNYLN, YTSRLHS, QQGNTLPPT, SYWMQ, TIYPGDGDTRYTQKFKG and RGIPRLWYFDV.
Antibodies reactive with b7-h3, immunologically active fragments thereof and uses thereof