In accordance with the present invention, methods are provided for the diagnosis and treatment of ADHD in a genetically defined subpopulation of ADHD. An exemplary method entails detecting the presence of at least one SNP in the SMYD3 gene in a nucleic acid sample of a subject, such as, for example, rs2105158, wherein if said SNP is/are present, said subject has an increased risk for developing ADHD. In one aspect of the present invention, a method for detecting a propensity for developing attention deficit hyperactivity disorder (ADHD) in a patient is provided. Further, methods of diagnosing a subject as having ADHD and methods of treating ADHD in a subject determined to have at least one ADHD-associated SNP are provided.
ASSOCIATION OF GENETIC VARIATIONS TO DIAGNOSE AND TREAT ATTENTION-DEFICIT HYPERACTIVITY DISORDER (ADHD)