A method for PET image reconstruction acquires PET data by a PET scanner; reconstructs from the acquired PET data a seed PET image; builds a feature space from the seed PET image and anatomical images co-registered with the seed PET image; performs a penalized maximum-likelihood reconstruction of a PET image from the seed PET image and the feature space using a penalty function that is calculated based on the differences between each voxel and its neighbors both on the PET image and in the feature space regardless of their location in the image.
Feature space based MR guided PET Reconstruction