A neurotrophic factor production accelerator which contains as an active ingredient a compound represented by the following formula (I): (I) [wherein R<1> represents a lower alkyl, aryl, ar(lower)alkoxy, or heterocyclic group which has been optionally substituted by a halogen; R<2> represents hydrogen or lower alkyl; R<3> represents a cyclo(lower)alkyl, aryl, or ar(lower)alkyl group which has been optionally substituted by a halogen; A represents -CO-, -SO2-, or lower alkylene; X represents nitrogen or CH; and Y represents -CO-, -SO2-, or -CONH-] or a salt, prodrug, or solvate of the compound. The neurotrophic factor production accelerator is useful for the prevention of and/or treatments for motor nerve and peripheral nerve diseases.
NEUROTROPHIC FACTOR PRODUCTION ACCELERATOR