The disclosure concerns a method for resistance of epilepsy by suppressing the function of alpha 1G protein of T-type calcium channels, use of suppressor of alpha 1G protein for prevention or treatment for epilepsy, knockout mice resisting epilepsy by disrupting alpha 1G subunit of T-type calcium channel, and preparation method thereof. The alpha1G-knockout transgenic mouse can be used for investigating the relationship between diseases particularly neuropathy or psychopathy and the function of alpha1G T-type calcium channel via various behavioral tests since alpha1G subunit is mainly expression in central nervous system (CNS) and pheripheral nervous system (PNS). Further, the alpha1G-knockout transgenic mouse can be used for screening antileptic agents.
Transgenic mouse whose genome comprises a homozygous disruption of its alpha1G gene, a method of preparing the same and use thereof