The present invention defines the parameters whereby “quantification” of isotope emission may occur and be clinically applied and provides a method for detecting abnormal coronary blood flow by “quantifying” emissions of a radiopharmaceutical after stressing the heart either pharmacologically or physiologically under “same state” conditions of stress-stress for detection of ischemic vascular (IVD) disease and the ability to differentiate (a) ischemic heart disease (IHD) due to narrowed coronary lumen and subsequent reduced lumen responsiveness to demand for more coronary blood flow and (b) vulnerable inflammatory plaque (VIP) disease, which reduces lumen responsiveness to blood flow demand with potential for sudden rupture and sudden cardiac death. The present invention also provides a method of detection of myocyte viability by using the “quantitative” method to differentiate “normal” functioning cardiac tissue from non-viable “infarcted” cardiac tissue and from “stunned/hibernating” myocytes, which may benefit from intervention. The present invention further provides a method for detection of IVD by detecting enhanced thymic activity associated with IVD and treatable causes. The present invention does so while reducing total patient imaging time, patient table time, radiation isotope doses and exposure to both patient and others through primary and secondary exposure to isotope emissions. In one embodiment, the nuclear isotope is technetium-99m hexakis 2-methoxyisobutylisonitrile (sestamibi).
Fleming method for tissue and vascular differentiation and metabolism (FMTVDM) using same state single or sequential quantification comparisons