PIPERAZINOISOTHIAZOLONES WITH PSYCHOTROPIC ACTIVITY There are disclosed compounds of the formula <IMG> wherein R1 and R2 are each, independently, hydrogen, lower alkyl, aryl of 6 to 10 carbon atoms or halo, or R1 and R2 taken together represent -CH2-, -CH2CH2-, <IMG> <IMG> <IMG> <IMG> or where the dotted lines represent optional double bonds; R3, R4, R5 and R6 are each, independently, hydrogen, lower alkyl, aryl of 6 to 10 carbon atoms or halo; R7 is 2-pyridinyl, 2-pyrimidinyl, 2-pyrazinyl, 3-pyridazinyl or phenyl or any of the foregoing R7 moieties substituted by lower alkyl, trifluorormethyl, cyano, nitro or halo, with the proviso that when R1 and R2 taken together represent <IMG> , then R7 is other than 2-pyridinyl, 2-pyrimidinyl, substituted pyrimidin-2-yl, phenyl or substituted phenyl; Z is -(CH2)n-, vinylene, -O-, or <IMG> X is lower alkylene, vinylene, O or NH; m is 2- 5; n is 0- 4; o is 1- 3; p is 1- 4; and the pharmaceutically acceptable salts thereof, and their use as antipsychotic/-anxiolytic agents having a low liability for extrapyramidal side effects.
PIPERAZINOISOTHIAZOLONES WITH PSYCHOTROPIC ACTIVITY