To provide a method for the prophylaxis and/or treatment of REM sleep behavior disorder, idiopathic REM sleep behavior disorder, or a combination thereof, in a subject in need thereof.SOLUTION: The present invention discloses a method comprising the step for administering to a subject a pyrazole derivative of a specific structure represented by Formula (I) that modulates the activity of the 5-HT2A serotonin receptor by therapeutically effective dose. There are also provided a pharmaceutical composition thereof and the use thereof for treating REM sleep behavior disorder.SELECTED DRAWING: Figure 1
DIARYL AND ARYL HETEROARYL UREA DERIVATIVES USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF REM SLEEP BEHAVIOR DISORDER