PROBLEM TO BE SOLVED: To provide new combinations containing a phosphodiesterase-5 inhibitor, and use thereof.SOLUTION: The present invention relates to pharmaceutical methods for treatment of various symptoms. Provided is a composition containing at least one phosphodiesterase-5 inhibitor combined with one or more of the following agents: a serotonin-slective reuptake inhibitor; serotonin-noradrenaline reuptake inhibitor; cholinesterase inhibitor; dopamine agonist; or an agent suitable for increasing the chemical concentration of neurotransmitter, which is selected from other agents capable of a primary neurotransmission in amino acid, monoamine, neuropeptide, and synaptic gap. Also, provided is use thereof for treatment of neurodegenerative disease in a subject.
NEW COMBINATION CONTAINING PHOSPHODIESTERASE-5 INHIBITOR, AND USE THEREOF