PROBLEM TO BE SOLVED: To provide a method and a medicine for treating a subject having a risk of developing Alzheimer disease.SOLUTION: A composition containing low-dose pioglitazone is used for treating Alzheimer-type recognition functional disorder (e.g., delaying onset), in which the low dose pioglitazone is given at an amount effective for enhancing neural activity in the left hippocampus region of the brain of a human subject in an episode memory task. Further, a treatment method of Alzheimer disease includes administration of a medicine containing low-dose pioglitazone. The method can include determining whether or not the subject has a risk of developing Alzheimer disease based on the age of the subject and a TOMM40 523 genotype.SELECTED DRAWING: None
METHOD AND MEDICINE FOR TREATING ALZHEIMER DISEASE