The invention relates to a method and composition for treating a cognitive disorder associated with a central nervous system (CNS) impairment in a subject by using a combination of a synaptic vesicle protein 2A (SV2A) inhibitor, in particular, levetiracetam, and an acetylcholinesterase inhibitor (AChEI), in particular, donepezil. In particular, the invention relates to the use of a combination of levetiracetam and donepezil in treating a cognitive disorder associated with a central nervous system (CNS) impairment in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, mild cognitive impairment (MCI), amnestic MCI, age-associated memory impairment (AAMI), age related cognitive decline (ARCD), dementia, Alzheimer's disease (AD), prodromal AD, post traumatic stress disorder (PTSD), schizophrenia, amyotrophic lateral sclerosis (ALS) and cancer-therapy-related cognitive impairment.
METHOD AND COMPOSITION FOR TREATING A COGNITIVE DISORDER