The present invention relates to a cerebral organoid-motor neuron spheroid structure and a fabrication method therefor. The structure can be fabricated by co-culturing a cerebral organoid and motor neuron spheroids in a co-culture chip which is designed to bring the cerebral organoid and the motor neuron spheroids into independent contact with a proper culture medium. The structure can be effectively used for screening drugs for prevention or treatment of brain diseases causative of motor disturbance or for a toxicity assay because electrical signal change of motor neurons according to specific substances stimulating the cerebrum can be observed from the structure.
CEREBRAL ORGANOID-MOTOR NEURON SPHEROID STRUCTURE AND FABRICATION METHOD THEREFOR