Provided are a neurodegenerative disease marker β-spectrin and application thereof, and construction kit thereof, said marker comprising a phosphorylated β-spectrin protein. The application comprises phosphorylation of a β-spectrin proteotypic peptide fragment as a marker of neurodegenerative disease, used for determination and evaluation of symptoms of neurodegenerative diseases such as AD and PD; the sample pretreatment process of the constructed kit is simple, amount of sample consumption is low, accuracy is high, and it has important significance for clinical guidance in assisting the diagnosis of AD- and PD-related indicators.
NEURODEGENERATIVE DISEASE MARKER β-SPECTRIN AND APPLICATION THEREOF