The present invention relates to a method for enhancing the physiological an d therapeutic effects of an AMPA receptor potentiator in an animal by co- administration of an acetylcholinesterase inhibitor with the potentiator. Al so disclosed is a method for treating a cognitive disorder in an animal by co- administration of an AMPA receptor potentiator and an acetylcholinesterase inhibitor. In addition, a composition comprising an effective amount of an AMPA receptor potentiator and an effective amount of an acetylcholinesterase inhibitor is also disclosed.
ENHANCEMENT OF AMPAKINE-INDUCED FACILITATION OF SYNAPTIC RESPONSES BY CHOLINESTERASE INHIBITORS