Provided are methods for identifying Drosophila melanogaster mutants which have mutations affecting calorie sensing behavior. Also provided are methods for identifying agents that can interfere with calorie sensing behavior in D. melanogaster and in mammals. Also provided are methods to identify agents that affect neuronal response of Dh44 neurons or CRF neurons to metabolizing sugars.
ROLE OF DH44 AND HOMOLOGS IN CALORIE SENSING