2070812 9109311 PCTABS00005 Provided is a method for diagnosing in a living person an ubiquitin-associated neurodegenerative disease, such as Alzheimer's Disease, Pick's Disease, Parkinson's Disease or progressive supranuclear palsy. The method comprises assaying an aliquot of cerebral spinal fluid from the person for ubiquitin-immunoreactive substances. The invention rests on the surprising discovery that, in living persons with such diseases, but not in living persons without such diseases, there is a significant amount of ubiquitin-immunoreactive substances in the cerebrospinal fluid.
METHOD FOR DIAGNOSING NEURODEGENERATIVE DISEASES