PURPOSE: To obtain a medicine inhibiting an effect manifestes by an amino acid against NMDA receptor complex, by containing a specific 2-carboxyindole derivatives. CONSTITUTION: This medicine contains, as the active component, a compound expressed by the formula [X is a 1-4C alkylene; Z is H, a 1-4C alkyl, a (substituted)phenyl, a phenylalkyl; R is H, a halogen, a 1-4C alkyl, a 1-4C alkoxy, CF3 , OCF3 , OH, NO2 , NH2 , CN; R1 , R2 are each OH, OR3 (R3 is Z excluding H), NR4 R5 (R4 , R5 are each H, a 1-4C alkyl), OCH2 OR3 ] or its pharmaceutically permissible base adduct salt, for example, 3-(2-carboxyindol-3-yl) propionic acid. The medicine is useful for treatment of epilepsy, neurodegenerative disease, anxiety, and prevention of damage to cerebral tissues by ischemia/hypoxia/ hypoglycemia, and as analgesic for the tissues. The daily dose is in the range of 0.1-50mg/kg.
IRRITATIVE AMINO ACID ANTAGONISTIC AGENT