The present invention is directed to a tropane analog having the structure (I) wherein Ar is a selected substituted or unsubstituted aryl group; G=CO2CH3, COR, or CH=CHR; X=H, I, Br, Cl, F, NO2, COR, or, NH2; R=H or a substituted or unsubstituted lower alkyl group; and Z=O, S, or N. The tropane analogs of the invention bind to monoamine transporters in the mammalian brain, and are useful as diagnostic tools for analyzing the role of monoamine transporters in diseases such as depression, schizophrenia, major depression, attention-deficit hyperactivity disorder, obesity, obsessive compulsive disorders, and cocaine addiction.
Tropane analogs binding to monoamine transporters