Novel compounds of the formula <IMAGE> wherein n is an integer from 1 to 4 inclusive; R1 represents a mono-or disubstituent of hydrogen, lower alkyl(C1-C3), lower alkoxy(C1-C3), halogen, nitro or trifluoromethyl; R2 is cyano, carboxamido, ethyl carboxylate or halogen; R3 is hydrogen, straight or branched chain lower alkyl(C1-C3), alkenyl(C2-C3), alkynyl(C2-C3), cycloalkyl(C3-C6), hydroxyalkyl(C1-C3), dimethylaminoalkyl(C1-C3), ethylcarboxylate, alkyl(C1-C13)carbonyl, 1-(methylethyl)acetamide, cyclohexylethyl, phenyl, mono-or disubstituted phenyl (wherein the phenyl substituent is halogen, trifluoromethyl, lower alkyl(C1-C3) or lower alkoxy(C1-C3)), benzyl, mono-or disubstituted benzyl (wherein the benzyl substituent is halogen, lower alkyl(C1-C3), lower alkoxy(C1-C3) or trifluoromethyl), benzoyl, 4-methoxybenzoyl, straight or branched chain alkyl(C2-C3)phenyl, 4-chlorophenylphenylmethyl, 1,3-benzodioxol-5-ylmethyl, 1,3-benzodioxol-5-yl, 2-furanylcarbonyl, 2-pyrimidinyl, 2-pyridinyl, 4-morpholinyl-2-oxoethyl, 1-pyrrolidinyl-2-oxoethyl, bis(4-fluorophenyl)methyl, phenylcarboxamido, mono- and disubstituted phenylcarboximido (wherein the phenyl substituents is halogen, trifluoromethyl or lower alkyl(C1-C3)), adamantanoyl, 3-phenoxypropyl,5-chloro-2-methoxyphenylacetamide, (2-oxo-1-pyrrolidinyl)-2-butynyl, phenylmethylcarboxylate, or (2-phenyl-2_H-1,2,3-triazol-4-yl)methyl; R4 and R5 are independently hydrogen or lower alkyl(C1-C3); the dotted line between positions 6 and 7 of the pyrimidine ring represents the presence or absence of a double bond; and the pharmacologically acceptable salts thereof: methods of producing them; therapeutic compositions containing them: and methods of using them to treat anxiety, hypertension, depression, senile dementia, cognitive defects and other neural behavior problems in warm-blooded animals.
Method of treating cognitive and related neural behavioral problems