CCSF1R . 0 Li? ANTIGEN PRESENTING CELL NO ARC PRESENT CSF1 IL-34 CSFia_e IL-34 4 SUPPRESSION ACTIVATION CSF1R-Fc-CD4OL 7k. \':\' 4ACTIVATION VIA CD40 COMPETITIVE INHIBITION OF CSF1R (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 30 August 2018 (30.08.2018) WIP0 I PCT IiiimmomiolollmonolomolloomomioommovoimIE (10) International Publication Number WO 2018/157164 Al 1-1 71- 1-1 N 1-1 00 (51) International Patent Classification: A61K 38/00 (2006.01) C07K 19/00 (2006.01) C07K 14/705 (2006.01) C12N 15/11 (2006.01) (21) International Application Number: PCT/US2018/020039 (22) International Filing Date: 27 February 2018 (27.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/463,997 27 February 2017 (27.02.2017) US (71) Applicant: SHATTUCK LABS, INC. [US/US]; 3317 Bowman Ave., Austin, TX 78703 (US). (72) Inventors: SCHREIBER, Taylor; 3317 Bowman Ave., Austin, TX 78703 (US). FROMM, George; 3317 Bowman Ave., Austin, TX 78703 (US). DE SILVA, Suresh; 3317 Bowman Ave., Austin, TX 78703 (US). (74) Agent: ALTIERI, Stephen, L. et al.; Morgan, Lewis & Bockius LLP, 1111 Pennsylvania Avenue, NW, Washing- ton, DC 20004 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (54) Title: CSF1R-BASED CHIMERIC PROTEINS FIG. - IA el (57) : The present invention relates, in part, to, chimeric proteins which include the extracellular domain of colony stimulating 0 factor 1 receptor (CSF1R) and their use in the treatment of diseases, such as immunotherapies for cancer and/or an inflammatory disease.
CSF1R-BASED CHIMERIC PROTEINS