This invention relates to the use of an agent capable of binding and thus inhibit formation of a binary Vps10p-domain receptor:TrpV receptor complex, and/or formation of a further ternary Vps10p-domain receptor:TrkA:TrpV receptor complex for the preparation of a medicament for the inhibition of pain and pain signalling through said complex(es). The invention is thus beneficial in the preparation of a medicament for the treatment and/or prevention of neuropathic pain, chronic pain and acute pain. The invention furthermore relates to the identification of such agents and animal models for screening for such agents.
Modulation of the TrpV: Vps10p receptor system for the treatment of pain