FIELD: chemistry. ^ SUBSTANCE: invention relates to new compounds of the formula (I) Formula I , where: X is the following radical: , L is separately selected from -C(R)(R')-, -CO-, NR'-; n equals zero, unity, two, three, four, five, six, seven, eight, nine or ten; R, R' and R' are separately selected from hydrogen, alkyl; D is separately selected from -C(R9)- or -N-; A1 A2, A3, A4, A5, A6, A7, A8, E and G are separately selected from -CO-, -C(R10)(R11)-, =C(R10)-; R1, R2, R3, R9, R10 and R11 are separately selected from hydrogen, alkyl, alkoxyl, hydroxyl, haloge-nalkyl, halogen. The invention relates also to pharmaceutical compositions based on the above substances, to the use of these compounds for production of a pharmaceutical and to the method of treatment of cognitive disturbances. EFFECT: compounds are useful in treatment of cognitive disturbances. ^ 12 cl, 2 tbl, 24 ex.
INHIBITORS OF TWO SITES OF BINDING ACETYLCHOLINESTERASE FOR TREATMENT OF THE ALZHEIMER'S DISEASE