 A 4-[2-(Dimethylamino-1-(1-hydroxycyclohexyl)ethyl]- phenol-O-a-acyloxyalkyl ether derivative or a pharmaceutically acceptable salt or hydrate thereof has the formula (I) wherein: the configuration at the stereogenic center (*) may be R, S, or RS (the racemate); R1 is alkyl, alkoxy, cycloalkyl, or a optionally alkyl substituted cyclohexyl; R2 is H or alkyl or R1 and R2 may be concatenated such that R1-C(=O)-O-C(R2)(H)- forms an optionally substituted 2-benzofuran(1(3H)-one. The compounds are useful for treating depression; generalized anxiety disorder; panic disorder; post traumatic stress disorder; attention deficit disorder, with and without hyperactivity; anxiety; schizophrenia; cocaine addiction; alcohol addiction; premenstrual dysphoric disorder or autism.
 Ethers of O-desmethyl venlafaxine useful for treating central nervous system disorders