The present invention provides a novel immune lipid-polymer hybrid nanoparticle (LPHN) biochip and application thereof. The immune LPHN biochip is provided with a molecular probe which comprises molecular beacons (MB), Toehold-initiated molecular beacons (Ti-MB), biomolecule groups for performing catalyzed hairpin DNA circuit (CHDC), and quantum dots. Further, the immune LPHN biochip can be widelyapplied to molecular detection in various biological samples, environmental samples and food safety fields, in particular, biological information contained in biological samples.
Immune lipid-polymer hybrid nanoparticle biochip and application thereof