To provide a pharmaceutical intervention and method for treating a gait or limb impairment, particularly a gait or limb impairment including an impairment secondary to a disease or disorder.SOLUTION: A methylphenidate, particularly dextro-threo-methylphenidate, is administered to a subject to treat a gait or limb impairment secondary to a genetically acquired pre-frontal cortex processing disease or disorder, particularly multiple sclerosis, cerebral palsy, Angelman syndrome, Rett syndrome and Fragile-X syndrome.SELECTED DRAWING: Figure 1
PRE-FRONTAL CORTEX PROCESSING DISORDER AND GAIT AND LIMB IMPAIRMENT TREATMENT