Based on the reaction of mice in different behavioral experiments, the compound levorotatory tetrahydropalmatine is found to have multiple anti-mental disease effects at the same time, such as the anti-depression effect shown in a tail suspension test; an anti-social anxiety utility displayed in social and social novelty preference tests; an anti-manic attack effect shown in an anti-manic test; ananti-bidirectional emotional disorder effect obtained by combining the anti-depression effect and the anti-mania effect; and an anxiolytic effect shown in an elevated cross maze test. It is shown that the dosage required by the series of medicinal effects to be given to mice is far lower than the dosage of analgesic drugs. The research results show that the levorotatory tetrahydropalmatine and pharmaceutical compositions thereof are provided for the treatment of 'depressant disorders', 'bipolar and related disorders', 'manic episodes' and 'anxiety disorders' as these disorders are defined inDiagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-5).
APPLICATION OF LEVOROTATORY TETRAHYDROPALMATINE TO THE TREATMENT OF DEPRESSION DISORDERS, BIPOLAR AND RELATED DISORDERS, MANIC EPISODES AND ANXIETY DISORDERS