Muramyl peptide compounds which: (a) are non-pyrogenic; and/or (b) ameliorat e endotoxin-induced weight loss and/or hypophagia; and/or (c) reduce TNF production; and/or (d) stimulate macrophag es to process endotoxin are useful, in the treatment of septic shock; cachexia and other life-threatening inflammatory conditions . Preferred compounds include N-acetyl-gluco-saminyl-N-acetyl-muramyl-L-alanyl-D-isoglutamine (GMDP) and N - acetyl-glucosaminyl-N-acetyl-muramyl-L-alanyi-D-glutamic acid (GMDP-A).
MURAMYL COMPOUNDS FOR TREATMENT OF SEPTIC SHOCK