Isolated and purified human and clam ubiquitin carrier peptide (Ubc) which is involved in the ubiquitination of cyclin A and/or B. Also disclosed are dominant negative selective inhibitors of Ubc, nucleic acids encoding such polypeptides, antibodies specific for such polypeptides, and methods of their use.
Human and clam cyclin-selective ubiquitin carrier polypeptides (E2) that are involved in the ubiquitination of cyclins A and B, inhibitors of these E2 polypeptides are included