Apparatus and methods associated with controlling seizure activity with electrical stimulation that either suppress axonal conduction between brain structures and/or that generate a desired response in a targeted neuronal pool are described. One example apparatus includes an implantable stimulating electrode that provides an electrical stimulus to fiber tracts of the hippocampal commissure of the brain of a subject. The stimulus may be a high frequency structure that prevents communication of signals associated with an epileptic episode and/or prevents seizure activity in a target nucleus. The example apparatus may also include a detection logic that detects specific electrical activity in the central nervous system that identifies that an epileptic episode is imminent. The example apparatus includes a pacing system to selectively configure and apply the electrical stimulus to fiber tracts of the hippocampal commissure of the brain.
Controlling seizure activity with electrical stimulation