Rab DGI alpha knockout animals which are a non-human individual, wherein a genomic gene encoding a low-molecular weight GTP-binding protein Rab GDI alpha has been substituted by a gene with the deletion of this function, and its offspring. These Rab DGI alpha knockout animals are useful in clarifying molecular mechanisms concerning memory and learning and developing diagnostic and therapeutic methods for neural diseases such as epilepsy, remedies therefor, etc. Moreover, these knockout animals are useful as model animals of neural disease XLMR.
Rab GDI alpha KNOCKOUT ANIMALS