The present invention provides methods for reducing alcohol drinking behavior in humans and treating acute alcohol poisoning through the use of neutral or negative modulating agents of the neurosteroid sites on GABAA receptors. These agents avoid the unwanted side-effects of opiate antagonists and displays specificity toward the neurosteroid binding sites on GABAA receptors.
TREATMENT OF ALCOHOL ABUSE AND ALCOHOLISM USING MODULATORS OF NEUROSTEROID BINDING SITES ON GABAA RECEPTORS