The present invention relates to a method for generating a brain metabolite network using a time-varying function for magnetic resonance spectroscopy-based brain metabolites, which, for monitoring the brain metabolite network, detects spectrum at certain time intervals by using magnetic resonance spectroscopy (MRS) equipment for specific regions of the brain, obtains the time-varying function of the brain metabolite in which the amount of metabolite from the detected spectrum shows a quantitative change over time, and configures a brain metabolite network by using the obtained time-varying function. The present invention can contribute to revealing the interrelationship of metabolites between regions of the brain through a correlation coefficient. In addition, two regions connected in the brain functional network which connects the regions of the brain performing the same function speculates that an amount of a metabolite performing a specific function in a corresponding region coincidentally increases and decreases through the brain metabolite network of the present invention. Accordingly, it is possible to identify how the two regions can interact and through which mechanism the two regions are functionally related as well as identifying a functional association of the two regions. Therefore, the identified results can provide precise and accurate information to the development of diagnosis and treatment method of brain diseases, and also can be used as an indicator to monitor and evaluate a treatment process.
Brain metabolite network generation method using time varying function based on MRS