PROBLEM TO BE SOLVED: To provide a steroid sparing agent for reducing and/or eliminating the need for steroid therapy in a subject in the treatment of inflammatory bowel diseases (IBD), asthma, Crohn's disease (CD), multiple sclerosis (MS), rheumatoid arthritis (RA), graft versus host disease (GVHD), host versus graft disease, and various spondyloarthroses.SOLUTION: An immunologically active fragment of a monoclonal antibody, especially natalizumab in which α4 β1 integrin is connected is used for a steroid sparing agent.
STEROID SPARING AGENT AND METHOD FOR USING THE SAME