H:\r\Intrwovn\NRPortbl\DCC\RR\64203I8_I.doc-13/06/2014 Disclosed are methods and agents for detecting the presence or diagnosing the risk of ankylosing spondylitis (AS) in mammals. These methods are based on the detection of polymorphisms within any one or more of the ARTS-1 gene, the IL-23R gene, the TNFR1 gene locus, the TRADD gene locus and the chromosome loci 2P15 and 21Q22. The present invention also features methods for the treatment or prevention of AS based on the diagnosis.
Diagnostic markers for ankylosing spondylitis and uses thereof