The present invention relates to a probe for detecting autophagolysosomes and a use thereof. More specifically, the probe includes: an LC3-interacting region (LIR) motif derived from FYVE and coiled-coil domain containing 1 (FYCO1) genes or mutants thereof; an N-terminal hydrophobic domain of Aplysia phosphodiesterase 4 (ApPDE4); and a reporter fluorescent protein part. The present invention can address various side effects caused by overexpression of LC3 in a conventional autophagolysosome detection method to effectively detect the autophagolysosomes specifically and precisely while obtaining and utilizing various in-vivo information related to a child action.
Probes for detecting autophagosome derived from FYCO1 and uses thereof