- 2018226433 A method and system of treating a neurological disorder in a patient, comprising: measuring neuronal activity at two separate neural sites in the brain of the patient while the brain functions as a modular scale free hierarchical network based on cross frequency coupling resulting in a noisy hierarchical organization; detecting cross-frequency coupling in the measured neuronal activity of the two separate neural sites, wherein the detecting cross-frequency coupling comprises identifying a frequency component of the cross-frequency coupling in a pathological frequency range; applying electrical stimulation to one or more sites in the brain of the patient in response to identifying the frequency component of the cross-frequency coupling in the pathological frequency range.
METHODS OF SENSING CROSS-FREQUENCY COUPLING AND NEUROMODULATION