A method is provided for using alpha2delta subunit calcium channel modulators or other compounds that interact with the alpha2delta calcium channel subunit in combination with one or more compounds with smooth muscle modulatory effects to treat pain. According to the present invention, alpha2delta subunit calcium channel modulators include GABA analogs (e.g., gabapentin and pregabalin), fused bicyclic or tricyclic amino acid analogs of gabapentin, and amino acid compounds. Compounds with smooth muscle modulatory effects include antimuscarinics, beta3 adrenergic agonists, spasmolytics, neurokinin receptor antagonists, bradykinin receptor antagonists, and nitric oxide donors.
METHODS FOR TREATING PAIN USING SMOOTH MUSCLE MODULATORS AND alpha2delta SUBUNIT CALCIUM CHANNEL MODULATORS