A compound according to Formula (I); a pharmaceutical composition comprising the compound; and the use of the compound or pharmaceutical composition for the manufacture of a medicament for use in the treatment of pain e.g. centrally mediated pain, peripherally mediated pain, structural or soft tissue injury related pain, progressive disease related pain, neuropathic pain, acute or chronic pain wherein the chronic pain may be caused by neuropathic conditions, diabetic peripheral neuropathy, post-herpetic neuralgia, trigeminal neuralgia, post-stroke pain syndromes, cluster or migraine headaches, arthritis, psoriasis, asthma, inflammatory bowel disease, respiratory function disorder, functional diarrhea, non-ulcerogenic dyspepsia, incontinence or irritable bowel syndrome.
Novel substituted 4-phenyl-4-[1H-imidazol-2-YL]-piperidine derivatives and their use as selective non-peptide delta opioid agonists