PROBLEM TO BE SOLVED: To provide therapeutic methods of migraine and diseases associated with it.SOLUTION: The present invention provides a therapeutic method of a patient with migraine including symptoms associated with migraine, such as migraine-associated vertigo, the method comprising administering a therapeutically effective amount of an invertebrate presynaptic neurotoxin in a pharmacologically safety form, for example, botulinum toxin, to a patient. The method is performed against a trigeminal nerve-cervix system so that the neurotoxin can be transported from a distal site to a central site. The administration is performed by extramuscularly injecting a neurotoxin to the aponeurosis/fascia of the scalp so that the neurotoxin can be diffused in a distal sensory nerve in order to allow it to concentrate in the occipital region-parietal region-frontal region. The method comprises intraorally and extramuscularly injecting the neurotoxin to the ganglial hole so that the neurotoxin can be diffused in the ganglion pterygopalatine, and the administration is performed against the trigeminal nerve-cervix system so as to enable the axonal transport of the neurotoxin from a distal site to a central site.SELECTED DRAWING: Figure 1
TREATMENT OF MIGRAINE USING PRESYNAPTIC NEUROTOXIN