Human- or mouse-origin genes respectively encoding proteins (mSSH-1L, -2L, -3L and hSSH-2L and -3L)having the amino acid sequences represented by SEQ ID NOS:2,4,6,8.10. As the results of functional analysis, it is found out that mSSH-1L, -2L and -3L each lowers the cofilin phosphorylation level in cells. All of the above proteins seemingly dephosphorylate cofilin and thus participate in the regulation of actin cell skeleton. Thus, it is expected that these proteins are widely usable medically and industrially.
ENZYMES DEPHOSPHORYLATING ACTIN DEPOLYMERIZING FACTOR COFILIN AND GENES THEREOF