To provide an improved animal model in which human neurodegenerative disease and/or inflammatory disease are precisely reproduced.SOLUTION: There is provided a non-human animal model regarding amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and/or glomerulonephritis. In various embodiments, there is provided a non-human animal model regarding ALS and/or FTD, a non-human animal model characterized by destruction (e.g., deficiency of the total coding region) in C9ORF72 locus. In some embodiments, destruction in C9ORF72 locus affects including the destruction one or a plurality of neurons of a non-human animal. In some embodiments, destruction in C9ORF72 locus affects including the destruction one or a plurality of spleen, cervical lymph node, bone marrow, kidney, and blood of a non-human animal.SELECTED DRAWING: Figure 1A
NON-HUMAN ANIMAL HAVING DESTRUCTION IN C9ORF72 LOCUS