A system for modulating targeted neural and non-neural tissues of a nervous system structure comprising electrical stimulation device 100 with an electrode 120 sized and configured for placement adjacent a mucosal tissue, the electrode configured to deliver electrical stimulation proximate the neural and non-neural tissue underlying the mucosal tissue. A controller 130 connects the electrode to a power source 180 and directs operation to selectively modulate the target structure and inhibit the perception of pain without damaging the mucosal tissue or interfering with other sensory or motor function. The pain may be inhibited for a period of 1-30 days and may comprise head and face pain, migraine, headache or neuralgia. The electrode may stimulate the gasserian or sphenopalatine ganglion (SPG). The system may have an elongate body for insertion through the nostril to the SPG or be configured for the mouth to stimulate an oral ganglia or peripheral nerve.
Device and method to selectively and reversibly modulate a nervous system structure to inhibit the perception of pain