This invention provides a method for reducing hyperalgesia following a pain-inducing procedure being performed on a subject which comprises administering to the subject an anesthetic which is an antagonist of the subject's nicotinic acetylcholine receptor, in an amount effective to inhibit the subject's perception of pain during the pain-inducing procedure; then performing the pain-inducing procedure on the subject; and administering to the subject a hyperalgesia-reducing amount of an agonist of the subject's nicotinic acetylcholine receptor such that the subject's hyperalgesia following the procedure is reduced. This invention also provides related methods and articles of manufacture.
Nicotine and/or nicotine agonists for the treatment of general anesthetic effects and side effects