A protein having activities of a human platelet activating factor acetylhydrolase, and represented by an amino acid sequence represented by the following formula (I) or an amino acid sequence having homology therewith; and a DNA encoding the protein: <table-cwu id='TABLE-US-00001'> <number>1</number> <table frame='none' colsep='0' rowsep='0' tabstyle='monospace'> <tgroup align='left' colsep='0' rowsep='0' cols='1'> <colspec colname='1' colwidth='217PT' align='left'/> <tbody valign='top'> <row> <entry></entry> </row> <row> <entry>Met Gly Val Asn Gln Ser Val Gly Phe Pro Pro Val</entry> </row> <row> <entry> </entry> </row> <row> <entry>Thr Gly Pro His Leu Val Gly Cys Gly Asp Val Met</entry> </row> <row> <entry> </entry> </row> <row> <entry>Glu Gly Gln Asn Leu Gln Gly Ser Phe Phe Arg Leu</entry> </row> <row> <entry> </entry> </row> <row> <entry>Phe Tyr Pro Cys Gln Lys Ala Glu Glu Thr Met Glu</entry> </row> <row> <entry> </entry> </row> <row> <entry>Gln Pro Leu Trp Ile Pro Arg Tyr Glu Tyr Cys Thr</entry> </row> <row> <entry> </entry> </row> <row> <entry>Gly Leu Ala Glu Tyr Leu Gln Phe Asn Lys Arg Cys</entry> </row> <row> <entry> </entry> </row> <row> <entry>Gly Gly Leu Leu Phe Asn Leu Ala Val Gly Ser Cys</entry> </row> <row> <entry> </entry> </row> <row> <entry>Arg Leu Pro Val Ser Trp Asn Gly Pro Phe Lys Thr</entry> </row> <row> <entry> </entry> </row> <row> <entry>Lys Asp Ser Gly Tyr Pro Leu Ile Ile Phe Ser His</entry> </row> <row> <entry> </entry> </row> <row> <entry>Gly Leu Gly Ala Phe Arg Thr Leu Tyr Ser Ala Phe</entry> </row> <row> <entry> </entry> </row> <row> <entry>Cys Met Glu Leu Ala Ser Arg Gly Phe Val Val Ala</entry> </row> <row> <entry> </entry> </row> <row> <entry>Val Pro Glu His Arg Asp Arg Ser Ala Ala Thr Thr</entry> </row> <row> <entry> </entry> </row> <row> <entry>Tyr Phe Cys Lys Gln Ala Pro Glu Glu Asn Gln Pro</entry> </row> <row> <entry> </entry> </row> <row> <entry>Thr Asn Glu Ser Leu Gln Glu Glu Trp Ile Pro Phe</entry> </row> <row> <entry> </entry> </row> <row> <entry>Arg Arg Val Glu Glu Gly Glu Lys Glu Phe His Val</entry> </row> <row> <entry> </entry> </row> <row> <entry>Arg Asn Pro Gln Val His Gln Arg Val Ser Glu Cys</entry> </row> <row> <entry> </entry> </row> <row> <entry>Leu Arg Val Leu Lys Ile Leu Gln Glu Val Thr Ala</entry> </row> <row> <entry> </entry> </row> <row> <entry>Gly Gln Thr Val Phe Asn Ile Leu Pro Gly Gly Leu</entry> </row> <row> <entry> </entry> </row> <row> <entry>Asp Leu Met Thr Leu Lys Gly Asn Ile Asp Met Ser</entry> </row> <row> <entry> </entry> </row> <row> <entry>Arg Val Ala Val Met Gly His Ser Phe Gly Gly Ala</entry> </row> <row> <entry> </entry> </row> <row> <entry>Thr Ala Ile Leu Ala Leu Ala Lys Glu Thr Gln Phe</entry> </row> <row> <entry> </entry> </row> <row> <entry>Arg Cys Ala Val Ala Leu Asp Ala Trp Met Phe Pro</entry> </row> <row> <entry> </entry> </row> <row> <entry>Leu Glu Arg Asp Phe Tyr Pro Lys Ala Arg Gly Pro</entry> </row> <row> <entry> </entry> </row> <row> <entry>Val Phe Phe Ile Asn Thr Glu Lys Phe Gln Thr Met</entry> </row> <row> <entry> </entry> </row> <row> <entry>Glu Ser Val Asn Leu Met Lys Lys Ile Cys Ala Gln</entry> </row> <row> <entry> </entry> </row> <row> <entry>His Glu Gln Ser Arg Ile Ile Thr Val Leu Gly Ser</entry> </row> <row> <entry> </entry> </row> <row> <entry>Val His Arg Ser Gln Thr Asp Phe Ala Phe Val Thr</entry> </row> <row> <entry> </entry> </row> <row> <entry>Gly Asn Leu Ile Gly Lys Phe Phe Ser Thr Glu Thr</entry> </row> <row> <entry> </entry> </row> <row> <entry>Arg Gly Ser Leu Asp Pro Tyr Glu Gly Gln Glu Val</entry> </row> <row> <entry> </entry> </row> <row> <entry>Met Val Arg Ala Met Leu Ala Phe Leu Gln Lys His</entry> </row> <row> <entry> </entry> </row> <row> <entry>Leu Asp Leu Lys Glu Asp Tyr Asn Gln Trp Asn Asn</entry> </row> <row> <entry> </entry> </row> <row> <entry>Leu Ile Glu Gly Ile Gly Pro Ser Leu Thr Pro Gly</entry> </row> <row> <entry> </entry> </row> <row> <entry>Ala Pro His His Leu Ser Ser Leu</entry> </row> </tbody> </tgroup> </table> </table-cwu>
Platelet activating factor acetylhydrolase, and gene thereof