A method and computer-implemented system for enhancing the capability of an imaging modality by coupling it with physiological models constructed at length scales below the resolution of the imaging modality. The present invention involves the use of multiple, coupled FEA analyses operating at different length scales to increase the utility of image data from a diagnostic imaging modality by achieving 'virtual resolution enhancement'. The preferred embodiment uses asymptotic homogenization FEA methods to map physiological data to the high-level model based on the diagnostic imaging modality and/or to micro-level model(s) based on theoretical or alternative imaging modalities.
METHOD FOR ACHIEVING VIRTUAL RESOLUTION ENHANCEMENT OF A DIAGNOSTIC IMAGING MODALITY BY USING COUPLED FEA ANALYSES