A monoclonal antibody that specifically binds to human TYRP1 (SEQ ID NO. 28) and comprises a VH chain with the amino acid sequence: QVQLVQSGSELKKPGASVKISCKASGYTFTSYAMNWVRQAPGQGLESMGWINTNTGNPTYAQGFTGRFVFSMDTSVSTAYLQISSLKAEDTAIYYCAPRYSSSWYLDYWGQGTLVTVSS (SEQ ID NO: 14), a CDRL1 having the sequence RASQSVSSYLA (SEQ ID NO: 4), a CDRL2 having the sequence DASNRAT (SEQ ID NO: 5), and a CDRL3 having the sequence QQRSNWLMYT (SEQ ID NO: 6). The antibody can be used to treat malignant melanoma.
Anti-tyrosinase-realted protein-1 (TYRP1) antibodies