PROBLEM TO BE SOLVED: To provide a treatment method for avoiding orthostatic hypotension due to α-adrenergic blocking properties of iloperidone (1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone) being an atypical antipsychotic.SOLUTION: The treatment method comprises administering the R enantiomer of the iloperidone metabolite represented by the formula in the figure (R-P88) at a dose of 1 to 24 mg once or twice per day.SELECTED DRAWING: None
ILOPERIDONE METABOLITE FOR USE IN TREATMENT OF PSYCHIATRIC DISORDERS