It is intended to find out a novel substance relating to human NMDA glutamate receptor subunit 3A (NR3A). A novel cDNA originating in human brain is isolated and the full base sequence thereof is analyzed. Then this base sequence is translated into an amino acid sequence followed by homology searching. As a result, it is found out that this sequence has a 93% homology with rat NR3A and thus identified as human NR3A. Further, it is confirmed that a gene encoding NR3A is significantly increased in the brain of patients with schizophrenia. Thus, it is concluded that NR3A is a substance relating to the pathology of schizophrenia.
NOVEL HUMAN N-METHYL-D-ASPARATATE (NMDA) GLUTAMATE RECEPTOR POLYPEPTIDE AND GENE ENCODING THE SAME