Methods, apparatus, and systems are provided for efficiently and accurately identifying individuals at risk for adverse effects from psychotropic or CNS-active treatment. Changes in a brain activity indicator (e.g. EEG cordance) are used to predict the adverse effects of treatment based on an experimentally derived cutoff value. For example, a reliable biological indicator is provided with high predictive capability for identifying, very early in the course of treatment (e.g. <= 48 hours after start of treatment), those individuals who are at greatest risk for worsening suicidality and other adverse effects of antidepressant drugs.
QUANTITATIVE EEG METHOD TO IDENTIFY INDIVIDUALS AT RISK FOR ADVERSE ANTIDEPRESSANT EFFECTS