Human striatal and midbrain organoids or spheroids are generated in vitro, which may be generated at least in part from human pluripotent stem (hPS) cells. Such spheroids model the regions of the human brain and comprise specific sets of cells that are associated with the striatum, including mature medium spiny neurons, and midbrain of a human, and that can be subsequently assembled with the cortex to form cortico-striatal-midbrain circuits in vitro.
HUMAN CELLULAR MODEL FOR INVESTIGATING CORTICO-STRIATAL-MIDBRAIN NEURAL PATHWAYS