The present invention includes a method for parallel magnetic resonance imaging termed Superresolution Sensitivity Encoding (SURE-SENSE) and its application to functional and spectroscopic magnetic resonance imaging. SURE-SENSE acceleration is performed by acquiring only the central region of k-space instead of increasing the sampling distance over the complete k-space matrix and reconstruction is explicitly based on intra-voxel coil sensitivity variation. SURE-SENSE image reconstruction is formulated as a superresolution imaging problem where a collection of low resolution images acquired with multiple receiver coils are combined into a single image with higher spatial resolution using coil sensitivity maps acquired with high spatial resolution. The effective acceleration of conventional gradient encoding is given by the gain in spatial resolution Since SURE-SENSE is an ill-posed inverse problem, Tikhonov regularization is employed to control noise amplification. Unlike standard SENSE, SURE-SENSE allows acceleration along all encoding directions.
Superresolution parallel magnetic resonance imaging