The invention relates to an antibody or fragment thereof and to a method of treatment and/or diagnosis using the antibody or fragment thereof. The antibody or fragment thereof is capable of binding to human alpha-synuclein, including monomeric, oligomeric and fibril forms of alpha-synuclein; is cross reactive with beta-synuclein and gamma synuclein; and binds an epitope of human alpha synuclein comprising the sequence MPSEEGYQDYEPEA (SEQ ID NO:2). A method for diagnosing a neurodegenerative disease associated with alpha-synuclein or of detecting alpha-synuclein comprises adding the antibody or fragment thereof to a biological sample from a subject, and detecting the presence or absence of a complex formed between alpha-synuclein and the antibody or fragment.
Alpha-Synuclein Antibodies (4H6)