Discloses a humanised binding protein capable of binding to human tumor necrosis factor-alpha (TNF-a), the antibody comprising the CDR regions with the sequences; CDR-H1: DYGVN CDR-H2: IWGDGSTDYDSTLKS CDR-H3: WHHGPVAY CDR-L1: KASQAVSSAVA CDR-L2: WASTRHT CDR-L3: QQHYSTPFT wherein the humanised binding protein comprises a human acceptor framework and has a dissociation constant (kD) of at most 1.56x10^-10 M, as measured by surface plasmon resonance
Tnf-alpha binding proteins