Method for providing external response based on changes in physiological status of biological sample determined by co-registration of sample images acquired in near-infrared and visible light, optionally by the user himself with a camera of a cell-phone cooperated with the data-processing unit. The NIR and visible image data are spatially co-registered with respect to spatial reference points associated with positions and orientations of camera to spatially coordinate the NIR and visible light images. Three-dimensional surface representing a sample's shape is determined based on stereo analysis of the first data. The NIR data is mapped onto such surface based on established spatial correlation to generate a topographic image representing the subsurface ROI and conforming to the sample's surface at multiple locations. Spatial distribution of the parameter characterizing a physiological function of the subsurface ROI of the sample is then determined based on the second and third data and the topographical image.
METHOD AND SYSTEM FOR NON-INVASIVE QUANTIFICATION OF BIOLOGIAL SAMPLE PHYSIOLOGY USING A SERIES OF IMAGES