The invention belongs to the technical field of pharmaceutical preparations, and relates to a nerve cell adhesion molecule (NCAM) mimic peptide modified pH sensitive gene bionic delivery system and application thereof in neurodegenerative diseases. The gene delivery system has a core-shell structure, the core is formed by electrostatic adsorption of genes by fluorinated low-molecular-weight cationic polymers, and the high transfection characteristic of a gene system can be ensured; the shell is composed of plasma protein, which is covalently connected with anhydride with pH sensitive characteristic, the binding force with the gene carrier core can be enhanced, can stably exists in blood and brain, and after entering lysosome of a target cell, it is beneficial for the gene core to realize lysosome escape and release genes in cytoplasm to exert its effect. The gene delivery system has dual characteristics of brain targeting and intracerebral focus cell targeting, the modification is simple, the operation is controllable, and has advantages of high transfection efficiency, low toxicity and good in-vivo stability.
NCAM mimic peptide modified pH sensitive gene bionic delivery system and application thereof