This invention provides compounds of formula I having the structure wherein: R<SUB>1 </SUB>and R<SUB>2 </SUB>are H, alkyl, cycloalkyl, alkoxy, halogen, fluorinated alkyl, -CN, -NH-SO<SUB>2</SUB>-alkyl, -SO<SUB>2</SUB>-NH-alkyl, alkyl amide, amino, alkylamino, dialkylamino, fluorinated, acyl, or aroyl; R<SUB>3</SUB>, R<SUB>4 </SUB>are H, alkyl, cycloalkyl or -CH<SUB>2</SUB>-cycloalkyl; R<SUB>5 </SUB>is H or alkyl; R<SUB>6 </SUB>is H or alkyl; and wherein the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof, as well as methods for using these compounds to treat central nervous system disorders, including obsessive-compulsive disorder, depression, anxiety, generalized anxiety disorder, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.
Cycloocta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives