The present invention provides compositions and methods directed to the use of SLITRK1 (slit and trk like 1) mutations to identify, diagnose, and treat disorders in the obsessive-compulsive disorder spectrum. Specifically, the present invention provides methods of identifying a subject having an increased risk of developing a disorder in the OCD spectrum and/or diagnosing a disorder in the OCD spectrum in a subject by detecting in the subject a mutation in the SLITRK1 gene.
SLITRK1 mutations associated with disorders in the OCD spectrum