Method, system and computer-accessible medium for determining at least one of axonal loss or myelin degradation can be provided. For example, it is possible to receive data based on at least one of a measure of diffusion of an axonal structure or a measure of a density of axons, and determine axonal loss and/`or myelin degradation based on the data. The determination can be based on axonal geometry of at least one parallel tube.
SYSTEMS, METHODS AND COMPUTER ACCESSIBLE MEDIUMS FOR DETERMINING NEURODEGENERATION