PROBLEM TO BE SOLVED: To provide: an isolated antibody or fragment thereof, capable of differentially recognizing a multi-dimensional conformation of one or more αβ-derived diffusible ligands; a method for preventing or treating diseases associated with the αβ-derived diffusible ligands; a method for identifying a treating agent for preventing binding of the αβ-derived diffusible ligands to a neuron; a method for detecting the αβ-derived diffusible ligands; and a method for diagnosing the diseases associated with the αβ-derived diffusible ligands.SOLUTION: The present invention relates to antibodies that differentially recognize multi-dimensional conformations of the αβ-derived diffusible ligands, also known as ADDLs. The antibodies can distinguish between Alzheimer's Disease and control human brain extracts, thereby detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLs, and tau-phosphorylation and prevent diseases associated with soluble oligomers of amyloid β1-42.
ANTI-ADDL ANTIBODY AND USE THEREOF