The invention relates to a compound having a positive allosteric modulating activity (PAM activity) for an 7 nicotinic acetylcholine receptor (7 nACh receptor). The present inventors have studied a PAM activity on an 7 nACh receptor, and they have found that a tetrahydrooxepinopyridine compound has a PAM activity on an 7 nACh receptor, thereby completing the present invention. The tetrahydrooxepinopyridine compound of the present invention has a PAM activity on an 7 nACh receptor and can be expected as an agent for preventing or treating dementia, cognitive impairment, schizophrenia, Alzheimer's disease, CIAS, negative symptoms of schizophrenia, inflammatory diseases or pain.
TETRAHYDROOXEPINOPYRIDINE COMPOUND