Disclosed is an aza-bicyclononane compound of formula I wherein A represents O or N(R1); R1 represents hydrogen, C1-C4alkyl, or CF3-, and wherein the rest of the substituents are disclosed in the specification. Also disclosed is the use of a compound of formula I for the manufacture of a medicament for the prevention and treatment of psychotic and neurodegenerative disorders or diseases or conditions in which alpha7 nAChR activation plays a role or is implicated.
1-Aza-bicyclo[3.3.1]nonanes