As the results of intensive studies of searching for a compound of a novel type inhibiting P2X2/3,3 receptors, it is found out that minodronic acid, which is one of bisphosphonates having an effect of regulating bone resorption, has a favorable effect of inhibiting the P2X2/3,3 receptors and is usable as a preventive or a remedy for various pains. Namely, a P2X2/3,3 receptor inhibitor, in particular, an analgesic which contains minodronic ac id or its salt as the active ingredient. The above-described ~P2X2/3 and/or P2X 3 receptor inhibitor~ inhibits the functions of P2X2/3,3 receptors which are known as molecules participating in various pains such as nociceptive pain, inflammatory pain and neurogenic pain. Owing to this effect, it is useful in preventing or treating various pains wherein the P2X2/3,3 receptors participate in pain transmission.
P2X RECEPTOR INHIBITOR