Paying attention to the risk fragility mechanism of the brain, it is intended to provide a remedy for mental diseases which covers deficiencies in the existing psychotropics and exhibits a novel function mechanism. More specifically speaking, there is found out a novel remedy for mental diseases having a novel mechanism which comprises regulating progressive disturbance in brain function corresponding to the risk fragility in a mental disease showing an undulatory appearance and progress pattern, thus continuously stabilizing stress responses in the remission stage and inhibiting the reoccurrence of symptoms. Then it is found out that this remedy is useful in treating integration disorder syndrome (schizophrenia), amphetamine-induced mental disease, manic-depression and so on. Namely, a remedy for mental diseases showing an undulatory appearance and progress pattern which comprises as the main ingredient a compound exhibiting an effect of regulating progressive disturbance in brain function corresponding to the risk fragility.
REGULATOR FOR MENTAL DISEASE RISK FRAGILITY