Disclosed is a C5 binding polypeptide, comprising a C5 binding motif, BM, which motif consists of an amino acid sequence selected from: i) E-X2-X3-X4-A-X6-X7-E-I-D-X11-L-P-N-L-X16-X17-X18-Q-W-X21-A-F-I-X25-X26-L-X28-D, wherein, independently of each other, - X2 is selected from H, Q, S, T and V; - X3 is selected from I, L, M and V; - X4 is selected from A, D, E, H, K, L, N, Q, R, S, T and Y; - X6 is selected from N and W; - X7 is selected from A, D, E, H, N, Q, R S and T; - X11 is selected from A, E, G, H, K, L, Q, R S, T and Y; - X16 is selected from N and T; - X17 is selected from I, L and V; - X18 is selected from A, D, E, H, K, N, Q, R, S and T; - X21 is selected from I, L and V; - X25 is selected from D, E, G, H, N, S and T; - X26 is selected from K and S; - X28 is selected from A, D, E, H, N, Q, S, T and Y; and ii) an amino acid sequence which has at least 86 % identity to the sequence defined in i), wherein the polypeptide binds to C5.
Polypeptides binding to human complement c5