An antibody-based GnRH receptor antagonist and methods of making and using same are disclosed. The antibody-based GnRH receptor antagonist is a GHR-106 monoclonal antibody (GHR-106) or an antigen-binding fragment thereof. GHR-106 or its IgG fragments can be utilized for therapeutic applications in the treatment of cancer and a range of sex hormone-related disorders or conditions in male or femalesubjects for which decapeptide GnRH antagonists are currently used.
USE OF GHR-106 MONOCLONAL ANTIBODY AS A GNRH ANTAGONIST