The present invention relates to the identification of STEP being as involve d in signaling pathways relating to psychotic diseases, including schizophreni a, and other disorders in which NMDA receptor dysfunction is implicated. The present invention provides methods for screening STEP inhibitors that modula te NMDA-R signaling. The present invention also provides methods and compositio ns for treatment of disorders mediated by abnormal NMDA-R signaling.
INTERACTION OF NMDA RECEPTOR WITH THE PROTEIN TYROSINE PHOSPHATASE STEP IN PSYCHOTIC DISORDERS