['28,', 'HANCOCK,', 'J.', 'C.', 'and', 'VOLLE,', 'R.', 'L.,', 'PhD,', 'University', 'of', 'Connecticut', 'School', 'of', 'Medicine,', 'Hartford', '"Blockade', 'of', 'conduction', 'in', 'vagal', 'fibers', 'by', 'ricopinic', 'drugs.”', '(Archives', 'Internationales', 'de', 'Pharmacodynamie', 'et', 'de', 'Therepie', '178/1:', '85-98,', 'March', '1569)', '"\'Conduction', 'of', 'vagel', "'C'", 'fibers', 'in', 'the', 'cat', 'was', 'readily', 'blocked', 'by', 'nicotine-like', 'drugs', '(dimethylphenylpiperazinium', '[DMPP],', '15', 'pg;', 'tetramethyl-', '2-10', 'pg;', 'nicotine,', '0.05-5', 'pg;', 'lobeline,', '5-h0', 'Jg3', 'carbachol,', '10-20', 'injected', 'into', 'the', 'arterial', 'supply', 'of', 'the', 'nodose', 'ganglion.', 'The', 'blockade', 'for', '1', '$o', '5', 'minutes', 'and', 'could', 'be', 'prevented', 'by', 'the', 'prior', 'adminis-', 'tration', 'of', 'hexamethonium.', 'There', 'wes', 'no', 'evidence', 'of', 'drug-induced', 'firing', 'during', 'blockade', 'of', 'conduction', 'by', 'nicotine~like', 'drugs.', '"Injection', 'of', 's', 'second', 'dose', 'of', 'DMPP', 'or', 'other', 'nicotinic', 'drugs', '1', 'to', '3', 'minutes', 'after', 'recovery', 'of', 'conduction', 'from', 'first', 'dose', 'of', 'nicotinie', 'drug', 'ceused', 'e', 'significantly', 'smaller', 'degree', 'of', 'blockade.', 'By', 'contrast,', 'conduction', 'blockade', 'by', 'potassium', 'chloride', '(KC1)', '(0.5-1.0', 'mg)', 'or', 'procaine', '(100-500', 'pg)', 'was', 'unaffected', 'by', 'prior', 'injection', 'of', 'nicotine-like', 'drugs.', 'Similarly,', 'prior', 'injection', 'of', 'KC1', 'or', 'proceine', 'did', 'not', 'affect', 'response', 'to', 'nicotine-like', 'drugs.', 'The', 'ability', 'of', 'the', 'nicotine-like', 'drugs', 'to', 'antagonize', 'the', 'response', 'to', 'e', 'second', 'injection', 'of', 'a', 'nicotine-like', 'drug', 'did', 'not', 'occur', 'in', 'nodose', 'ganglia', 'perfused', 'with', 'a', 'saline', 'solution.', 'Thus,', 'the', 'actions', 'of', 'nicoti-ic', 'substances', 'on', 'periph-', 'eral', 'nerve', 'resemblesthbse', 'seen', 'at', 'junctional', 'sites."', 'KALMAN,', 'E.,', 'Orthopedic', 'Clinic,', 'Lekerskej', 'Faculty', 'UK,', 'Bratislave,', 'Czechoslovekis', '"Osteosarkom', 'vyvolany', '3,4-benzpyrenom"', '{("Osteosarcoms', 'induced', 'by', '3,4=benz-~', 'pyréne").', '(Acta', 'Chirurgiee', 'Orthopaedicae', 'et', 'Trawmatologise', 'Cechoslovaca', '36/1:', 'hull,', 'February', '1969:', "Transletor's", 'sbstract)', 'In', 'the', 'first', 'stage', 'the', 'basic', 'technical', 'and', 'dosage', 'requirements', 'for', 'successful', 'tumor', 'induction', 'were', 'establighed.', 'In', 'the', 'second,', '7', 'mg', 'of', 'pure,', 'powdered,', 'crystelline', '3,4-benzpyrene,', 'with', 'or', 'without', 'paraffin', '(14', 'mg),', 'was', 'implented', 'in', 'the', 'femmr', 'of', 'white', '{Larsen', 'strain)', 'rate.', 'Controls', 'elther', 'got', 'paraffin', 'only', 'or', 'were', 'subjected', 'to', 'the', 'seme', 'operative', 'procedure', 'without', 'implantiation', 'of', 'either', 'substance.', 'In', 'the', 'group', 'of', '20', 'animals', 'implanted', 'with', '3,4-benzpyrene', 'only,', 'the', 'first', 'tumors', '(appearing', 'simultaneously', 'in', '5', 'of', 'the', 'rats)', 'were', 'observed', 'after', '6', 'months,', 'and', '10', 'had', 'developed', 'by', 'the', 'end', 'of', 'the', 'experimentel', 'period', '(14', 'months).', 'Thus,', 'positive', 'results', 'were', 'obtained', 'in', '75%;', 'the', 'majority', 'of', 'the', 'tumore', 'appearing', 'during', 'the', 'first', 'half', 'of', 'the', 'experimental', 'period.', 'Tumors', 'were', 'also', 'noted', 'in', '16', 'of', 'the', 'rats', 'given', '3,h-benzpyrene', '+', 'paraffin', '(53%).', 'None', 'of', 'the', 'rats', 'in', 'elther', 'of', 'the', 'control', 'groups', 'developed', 'tumors.', 'It', 'is', 'concluded', 'that', '3,l4-benzpyrene', 'is', 'definitely', 'capable', 'of', 'inducing', 'osteosarcomes', 'whose', 'histologic', 'and', 'roentgenclogic', 'features', 'closely', 'resemble', 'those', 'observed', 'in', 'wan.']