['FW:', 'NERC', 'News', 'Vol.', '1,', 'January', '2000', 'contributions', 'of', 'single', 'pollutants', 'and', 'their', 'interactions', 'to', 'observed', 'health', '|', 'effects.', 'The', 'strategy', 'for', 'accomplishing', 'these', 'goals', 'was', 'developed', 'in', '|', 'consultation', 'with', 'a', 'well-qualified,', 'broad-based', 'External', 'Scientific', 'Advisory', 'Committee,', 'and', 'LRRI', 'has', 'committed', 'to', 'managing', 'the', 'Center', 'explicitly', '|', 'within', 'the', 'scope', 'of', 'the', "Committee's", 'specific', 'recommendations', 'and', 'approvals.', ':', 'The', 'initial', 'strategy', 'is', 'to', 'conduct', 'a', 'series', 'of', 'identically', 'designed', 'studies', '|', 'of', 'the', 'cardiorespiratory', 'health', 'effects', 'of', 'inhalation', 'exposure', 'to', 'several', 'real-world,', 'source_-based', 'pollution', 'mixtures', 'in', 'order', 'to', 'create', 'a', 'matrix', 'of', 'data', 'on', 'composition', 'vs.', 'health', 'response.', 'The', 'aggregate', 'data', 'set', 'will', 'then', '_', 'be', 'used', 'to', 'test', 'the', 'limits', 'within', 'which,', 'given', 'detailed', 'data', 'collected', 'by', 'consistent', 'techniques,', 'it', 'is', 'possible', 'to', 'disentangle', 'the', 'contributions', 'of', "'", 'single', 'pollutants', 'and', 'classes,', 'and', 'their', 'interactions,', 'to', 'a', 'range', 'of', 'health', '’', 'multiple', 'cases', 'of', 'engine', 'emissions,', 'wood', 'smoke,', 'tobacco', 'smoke,', 'cooking', 'fumes,', 'road', 'dust,', 'and', 'power', 'plant', 'emissions.', 'The', 'health', 'assays', 'will', '|', 'encompass', 'irritation', 'and', 'inflammation,', 'allergic', 'responses', 'and', 'asthma,', '.', 'tespiratory', 'defenses,', 'lung/heart', 'function,', 'an', 'carcinogenic', 'potential.', 'The', 'identical', 'evaluation', 'of', 'each', 'atmosphere', 'will', 'constitute', 'a', '“core”', 'study,', 'and', 'the', 'results', 'of', 'each', 'will', 'be', 'published', 'as', 'the', 'aggregate', 'data', 'set', 'is', 'being', ':', 'developed.', '|', 'As', 'a', 'secondary', 'outcome,', 'the', 'core', 'studies', 'will', 'produce', 'new', 'health', 'information', 'and', 'comparisons', 'among', 'several', 'source', 'emissions', 'and', 'mixture', 'types', 'of', 'current', 'interest.', 'As', 'a', 'tertiary', 'outcome,', 'the', 'core', 'studies', 'will', 'create', 'many', 'opportunities', 'for', 'the', 'research', 'community', 'to', 'conduct', 'ancillary,', 'exploratory', 'studies', 'making', 'collaborative,', 'cost-effective', 'use', 'of', 'the', 'atmospheres', 'and', '|', 'biological', 'samples.', 'The', 'strategy', 'for', 'work', 'after', 'the', 'initial', 'data', 'set', 'is', 'developed', 'and', 'analyzed', 'will', 'depend', 'on', 'the', 'results', 'and', 'the', 'success', 'of', 'the', "'", 'strategy.', 'If', 'successful,', 'the', 'work', 'will', 'be', 'extended', 'to', 'include', 'atmospheric', 'reaction', 'products', 'and', 'natural', 'pollutants', 'which', 'are', 'of', 'interest', 'but', 'are', 'not', 'included', 'in', 'the', 'initial', 'atmospheres.', 'Five', 'pilot', 'projects', 'are', 'now', 'underway', 'while', 'the', 'core', 'studies', 'are', 'being', 'planned', 'and', 'initiated.', 'These', 'are', 'described', 'at', 'the', "Center's", 'web', 'site', '(http://Awww.nercenter.org/pilot.htm).', 'The', 'core', 'studies', 'will', 'each', 'involve', 'exposures', 'of', 'a', 'few', 'months', 'and', 'encompass', 'a', 'total', 'of', 'approximately', 'one', 'year.', '.', 'The', 'core', 'studies', 'will', 'begin', 'early', 'in', '2000', 'on', 'a', 'staggered', 'schedule,', 'with', 'the', 'number', 'of', 'atmospheres', 'studied', 'in', 'parallel', 'determined', 'by', 'funding.', 'Itis', 'estimated', 'that', 'development', 'of', 'the', 'initial', 'data', 'set', 'will', 'take', 'approximately', 'five', 'years.', ' ', '|', 'The', 'details', 'of', 'the', 'experimental', 'protocols', 'are', 'now', 'being', 'developed.', 'A', ',', 'workshop', 'involving', '20', 'external', 'health', 'researchers', 'was', 'held', 'in', 'September', '1999', 'to', 'develop', 'consensus', 'on', 'specific', 'health', 'assays.', 'External', 'input', 'is', 'similarly', 'being', 'obtained', 'regarding', 'the', 'statistical', 'aspects', 'of', 'experimental', 'design', 'and', 'the', 'specific', 'techniques', 'for', 'generating', 'the', 'atmospheres.', 'Progress', 'will', 'be', 'updated', 'at', 'the', 'NERC', 'web', 'site.', 'Parente', 'oC', ' ', 'What', 'are', 'the', "Center's", 'Collaborative', 'Opportunities?', ' ', ':', 'itis', 'an', 'explicit', 'goal', 'to', 'extend', "NERC's", 'value', 'by', 'serving', 'as', 'a', 'collaborative', 'resource.', 'To', 'implement', 'the', "Center's", 'research', 'strategy', 'within', 'plausible', '/', 'wpeleha', 'is', '|', 'outcomes.', 'The', 'six', 'atmospheres', 'recommended', 'by', 'the', 'Advisory', 'Committee', 'include', 'Page', '2', 'of', '4', ' ', 'OLeLPLsose', ' ', ' ', ' ', ' ', 'ou', '..', 'read.asp?command=open&obj=00000000E3E328F94537D21', '1', '9DD700805F8B95400', '07-Jan-2000']