['Final', 'Report', 'I-1729.005', 'measurement', 'of', 'the', '3-hydroxy-BaP', '(3-OH-BaP)', 'formed', 'according', 'to', 'Kouri', 'et', 'al.', '(1976).', 'AHH', 'units', 'are', 'expressed', 'as', 'pmole', '3-OH-BaP', 'formed/min/mg', 'microsomal', 'protein.', 'Evaluation', 'of', 'Test', 'Results', 'The', 'survival', 'in', 'each', 'group', 'is', 'presented,', 'as', 'are', 'any', 'unusual', 'observations', 'during', 'or', 'after', 'exposure', 'over', 'the', '6', 'weeks.', 'Blood', 'COHb', 'levels', 'from', '2', 'mice', 'per', 'group', 'at', 'weekly', 'intervals', 'are', 'also', 'presented.', 'Individual', 'animal', 'weights', '24', 'hours', 'prior', 'to', 'exposure', 'and', 'at', 'weekly', 'intervals', 'after', 'exposure', 'during', 'treatment', 'are', 'presented', 'for', 'each', 'group.', 'Individual', 'animal', 'pathologies', 'on', 'the', 'respiratory', 'tract', 'from', '9', 'animals', 'per', 'group', 'are', 'presented,', '3', 'animals/group', 'after', '3', 'weeks', 'and', '6', 'animals/group', 'after', '6', 'weeks).', 'Total', 'erythrocyte', 'counts,', 'total', 'leukocyte', 'counts,', 'hematocrit,', 'hemoglobin,', 'differential', 'leukocyte', 'counts,', 'blood', 'urea', 'nitrogen,', 'blood', 'glucose', 'and', 'other', 'clinical', 'chemistries', 'from', '3', 'animals/group', 'sacrificed', 'at', '3', 'weeks', 'and', '6', 'weeks', 'are', 'presented.', 'After', '6', 'weeks', 'of', 'treatment,', 'the', 'levels', 'of', 'AHH', 'in', 'lung,', 'liver,', 'and', 'kidney', 'tissues', 'from', '3', 'animals/group', 'and', 'the', 'Mitotic', 'Index', '(MI)', 'in', 'lung', 'tissue', 'from', '3', 'animals/group', 'were', 'determined.', 'Statistical', 'analyses', 'of', 'all', 'the', 'data', 'presented', 'were', 'performed', 'using', 'BMDP-79', 'Biomedical', 'Computer', 'Programs,', 'P-series', '(Dixon', 'and', 'Brown,', '1979).', 'Analysis', 'of', 'variance', '(ANOVA)', 'was', 'performed', 'comparing', 'the', 'equality', 'of', 'means', 'between', 'groups', 'and', 'an', 'F-statistic', 'calculated.', 'In', 'addition,', "Levene's", 'test', 'for', 'the', 'homogeneity', 'of', 'variances', 'was', 'calculated,', 'as', 'were', 'Welch', 'and', 'Brown-Forsythe', 'statistics', 'which', 'assume', 'unequal', 'variances.', 'The', 'data', 'were', 'entered', 'as', 'a', 'matrix', 'and', 'the', 'group', 'means', 'for', 'each', 'variable', '(column)', 'compared,', 'e.g.', 'body', 'weights', 'of', 'all', 'animals', 'on', 'test', 'for', '7', 'days.', 'Because', 'the', 'program', 'only', 'accepts', 'data', 'in', 'matrix', 'form,', 'values', 'that', 'are', 'not', 'recorded', 'must', 'be', 'entered', 'into', 'the', 'computer', 'as', '"missing"', 'as', 'opposed', 'to', 'zero', 'and', 'are', 'omitted', 'from', 'analysis.', 'Significant', 'differences', 'between', 'individual', 'means', 'were', 'determined', 'by', 'calculating', 'a', 'least', 'significant', 'range', 'using', 'a', 'Studentized', 'Range', 'Test', 'modified', 'for', 'unequal', 'sample', 'sizes', '(Sokal', '&', 'Rohlf,', '1969).', 'Criteria', 'For', 'Determination', 'of', 'Valid', 'Tests:', 'None', 'of', 'the', 'sham-exposed', 'animals', 'should', 'die', 'or', 'show', 'signs', 'of', 'toxicity.', 'COHb', 'levels', 'in', 'the', 'smoke-exposed', 'groups', 'should', 'be', 'statistically', '(p', '<', '0.05)', 'increased', 'relative', 'to', 'the', 'sham-exposed', 'controls.', '2665L68S', '15']