[' ', ' ', '‘ae', 'conduct', 'controlled', 'evaluations', 'of', 'voucher', 'incentive', 'therapies', 'for', 'pregnant', 'drug', 'abusing', 'women', 'enrolled', 'in', 'treatment', 'at', 'the', 'Canter', 'for', 'Addiction', 'and', 'Pregnancy', '(CAP)', 'that', 'target', 'program', 'attendance', 'and', 'participation', 'as', 'well', 'as', 'reduced', 'drug', 'use', 'in', 'order', 'to', 'improve', 'both', 'maternal', 'and', 'fetal', 'outcomes.', 'Overall,', 'these', 'components', 'represent', 'a', 'coordinated', 'research', 'effort', 'that', 'will', 'provide', 'systematic', 'information', 'about', 'the', 'mechanisms', 'and', 'effectiveness', 'of', 'incentive', 'therapies', 'for', 'treatment', 'cf', 'substance', 'abuse.', 'Valuable', 'information', 'will', 'be', 'obtained', 'about', 'the', 'optimal', 'conditions', 'for', 'applying', 'these', 'interventions', 'as', 'well', 'as', 'their', 'utility', 'across', 'several', 'specific', 'populations', 'of', 'drug', 'abusers.', '6/7/399', 'DIALOG(R)File', '266:Fed.', 'Res.', 'in', 'Progress', '(¢)', 'format', 'only', '1995', 'Dialog', 'Info.Svca.', 'All', 'rta.', 'reserv.', '0124947', 'IDENTIFYING', 'NO.:', '1P50DA09252-01', '0004', 'AGENCY', 'CODE:', 'CRISP', 'ENHANCING', 'EFFICACY', 'OF', 'NICOTINE', 'PATCH', 'TREATMENT', 'PRINCIPAL', 'INVESTIGATOR:', 'GARITI,', 'PETER', 'ADDRESS:', 'UNIVERSITY', 'OF', 'PENNSYLVANIA', 'DEPT', 'OF', 'PSYCHIATRY', 'PHILADELPHIA,', 'PA', '19104-6178', 'PERFORMING', 'ORG.:', 'UNIVERSITY', 'OF', 'PENNSYLVANIA,', 'PHILADELPHIA,', 'PENNSYLVANIA', 'SPONSORING', 'ORG.:', 'NATIONAL', 'INSTITUTE', 'ON', 'DRUG', 'ABUSE', 'FY', ':', '94', 'TYPE', 'OF', 'AWARD:', 'New', 'Award', '(Type', '1)', 'SUMMARY:', 'The', 'overall', 'goal', 'of', 'this', 'proposal', 'is', 'to', 'develop', 'an', 'effective', 'treatment', 'for', 'smoking', 'cessation', 'in', 'a', 'diverse', 'population.', 'The', 'major', 'specific', 'aim', 'is', 'to', 'compare', 'the', 'short', 'and', 'long-term', 'efficacy', 'of', 'transdermal', 'nicotine', 'detoxification', '(TN)', 'combined', 'with', 'individualized', 'manually', 'driven', 'cognitive', '.', 'behavioral', 'therapy', '(ICP)', 'with', 'that', 'of', 'a', 'control', 'condition', 'consisting', 'of', 'transdermal', 'nicotine', 'detoxification', '(TN)', 'plus', 'an', 'individually', 'oriented', 'commercially', 'available', 'smoking', 'cessation', 'video', 'tape', 'series', '(IVT)', 'and', 'brief', 'diacusasion', 'of', 'the', 'same', 'duration', 'as', 'the', 'ICB.', 'Completion', 'of', 'treatment', 'and', 'asmeking', 'cessation', 'and', 'reduction', 'rates', 'at', '3', 'months,', '6', 'months,', 'and', '1', 'year', 'will', 'be', 'the', 'measures', 'of', 'efficacy.', 'Secondary', 'aims', 'are:', '1.)', 'to', 'compare', 'treatment', 'completion', 'rats', 'and', 'cessation', 'rates', 'of', 'smokers', 'with', 'a', 'history', 'of', 'an', 'Axis', 'I', 'disorder', 'to', 'those', 'without', 'a', 'history', 'of', 'an', 'Axis', 'I', 'disorder', '(including', 'psychoactive', 'substance', 'use', 'disorders);', '2.)', 'to', 'determine', 'the', 'extent', 'to', 'which', 'the', 'severity', 'of', 'nicotine', 'dependence', 'at', 'baseline', 'is', 'a', 'negative', 'predictor', 'of', 'treatment', 'response,', 'reflected', 'in', 'treatment', 'completion', 'and', 'smoking', 'cessation', 'and', 'reduction', 'rates', 'at', '3,', '6,', 'and', '12', 'months', 'post-treatment', 'entry;', '3.)', 'to', 'determine', 'the', 'predictiva', 'validity', 'of', 'pre-', 'and', 'post-treatment', 'cue', 'reactivity;', '4.)', 'to', 'determine', 'whether', 'there', 'ia', 'a', 'positive', 'relationship', 'between', 'the', 'initial', 'level', 'of', 'motivation', 'to', 'quit', 'amoking', 'and', 'actual', 'smoking', 'cessation;', '5.)', 'to', 'identify', 'social', 'and', 'demographic', 'characteristic', 'associated', 'with', 'positive', 'cutcome', 'and;', '(6.)', 'to', 'group', 'assignment.', 'This', 'is', 'an', 'outpatient,', 'prospective,', 'matched,', 'random', 'assignment', 'experimental', 'study.', 'Seventy', 'medically', 'and', 'psychiatrically', 'stable', 'nicotine', 'dependent', 'cigarette', 'smokers', 'will', 'receive', 'ten', 'consecutive', 'weeks', 'of', 'a', 'standard', 'regimen', 'for', 'nicotine', 'withdrawal', '(TN)', 'plus', '16', 'concurrent', 'weeks', 'of', 'individualized', 'cognitive', 'behavioral', 'therapy', '(ICB)', 'while', 'a', 'second', 'group', 'of', '70', 'smokers', 'with', 'similar', 'characteristics', 'will', 'receive', 'the', '(TN)', 'treatment', 'Plus.', '16', 'concurrent', 'weeks', 'of', 'educational', 'videotapes', 'about', 'smoking', 'and', 'its', 'adverse', 'consequences', '(IVT).', 'The', '16', 'week', 'experimental', 'program', 'and', 'the', 'control', 'group', 'programs', 'must', 'be', 'completed', 'by', '20', 'weeks.', 'The', 'two', 'groupa', 'will', 'be', 'compared', 'with', 'respect', 'to', 'treatment', 'participation', 'and', 'for', 'amoking', 'cessation', 'and', 'smoking', 'reduction', 'rates', 'will', 'be', 'measured', 'at', '3', 'months,', '6', 'months,', 'and', '1', 'year.', 'Smoking', 'outcomes', 'will', 'be', 'measured', 'by', 'self-report', 'and', 'confirmed', 'by', 'exhaled', 'carbon', 'monoxide', 'measurements', 'and', 'urine', 'nicotine', 'concentrations.', '6/7/400', 'DIALOG(R)File', '266:Fed.', 'Res.', 'in', 'Progress', '(c)', 'format', 'oniy', '1995', 'Dialog', 'Info.Svcs.', 'Ali', 'rts.', 'reserv.', '51140', '2766', 'sl', ' ']