['IDENTIFYING', 'NO.:', '5P01NS16332-12', 'g001', 'AGENCY', 'CODE:', 'CRISP', 'STROKE', 'PREVENTION', 'IN', 'YOUNG', 'WOMEN', 'PRINCIPAL', 'INVESTIGATOR:', 'KETTNER,', 'STEVEN', 'J', 'ADDRESS:', 'UNIV', 'OF', 'MARYLAND', 'HOSPITAL', '22', 'S', 'GREENE', 'STREET', 'BALTIMORE,', 'MD', '21201', 'PERFORMING', 'ORG.:', 'UNIVERSITY', 'OF', 'MARYLAND', 'BALT', 'PROF', 'SCHOOL,', 'BALTIMORE,', 'MARYLAND', 'SPONSORING', 'ORG.:', 'NATIONAL', 'INST', 'OF', 'NEUROLOGICAL', 'DISORDERS', 'AND', 'STROKE', 'FY', ':', '94', 'TYPE', 'OF', 'AWARD:', 'Noncompeting', 'Continuation', '(Type', '5)', 'SUMMARY:', 'NO', 'SUBPROJECT', 'ABSTRACT', 'AVAILABLE.', 'SEE', 'PARENT', 'GRANT.', '6/7/54', 'DIALOG(R)File', '266:Fed.', 'Res.', 'in', 'Progress', '(c)', 'format', 'only', '1995', 'Dialog', 'Info.Sves.', 'All', 'rts.', 'reserv.', '0150308', 'IDENTIFYING', 'NO.:', 'SPO1NS14304-16', '0036', 'AGENCY', 'CODE:', 'CRISP', 'A', 'POPULATION-BASED', 'STUDY', 'OF', 'NEUROPATHY', 'AMONG', 'DIABETICS', 'IN', 'ROCHESTER,', 'MN', 'PRINCIPAL', 'INVESTIGATOR:', 'DYCK,', 'PETER', 'JAMES', 'ADDRESS:', 'MAYO', 'FOUNDATION', '200', 'FIRST', 'STREET', 'SOUTHWEST', 'ROCHESTER,', 'MN', '55905', 'PERFORMING', 'ORG.:', 'MAYO', 'FOUNDATION,', 'ROCHESTER,', 'MINNESOTA', 'SPONSORING', 'ORG.:', 'NATIONAL', 'INST', 'OF', 'NEUROLOGICAL', 'DISORDERS', 'AND', 'STROKE', 'FY', ':', '94', 'TYPE', 'OF', 'AWARD:', 'Noncompeting', 'Continuation', '(Type', '5)', 'SUMMARY:', 'We', 'have', 'prospectively', 'evaluated', 'a', 'cohort', 'of', '380', 'diabetics', 'from', 'Rochester,', 'MN', 'and', 'have', 'found:1)', 'the', 'cohort', 'is', 'representative', 'of', 'diabetics', 'in', 'Rechester,', 'MN;', '2)', 'approximately', 'one-half', 'do', 'not', 'have', 'neuropathy;', 'one-third', 'have', 'asymptomatic', 'neuropathy', 'without', 'weakness', 'of', 'foot', 'dorsiflexion;', 'and', '15%', 'of', 'ID', 'and', '12%', 'of', 'NID', 'diabetics', 'had', 'symptomatic', 'neuropathy', 'but', 'only', '6%', 'and', '1%', 'of', 'these,', 'respectively,', 'had', 'weakness', 'of', 'foot', 'dorsiflexion;', '3)', 'neuropathy', 'test', 'results', 'were', 'sufficiently,', 'had', 'weakness', 'of', 'foot', 'dorsiflexion;', '3)', 'neuropathy', 'test', 'results', 'were', 'sufficiently', 'sensitive', 'to', 'detect', 'statistically', 'significant', 'worsening', 'in', '24', 'mo;', 'and', '4)', 'various', 'risk', 'factors', 'were', 'found', 'to', 'be', 'correlated', 'with', 'staged', 'severity', 'of', 'neuropathy', 'and', 'also', 'with', 'change', 'in', 'neuropathy', 'test', 'results.', 'Because', 'we', 'have', 'recruited', 'a', 'unique', 'diabetic', 'cohort,', 'representative', 'of', 'Rochester', 'diabetics,', 'have', 'demonstrated', 'that', 'they', 'can', 'be', 'maintained', 'in', 'study', 'over', 'long', 'times,', 'shown', 'that', 'the', 'battery', 'of', 'nerve', 'evaluations', 'obtained', 'at', 'periodic', 'intervals', 'are', 'senaitive,', 'reproducible,', 'and', 'meaningful', 'of', 'neuropathic', 'change,', 'and', 'that', 'the', 'cost', 'is', 'modest', 'by', 'comparison', 'to', 'other', 'studies', 'of', 'this', 'type,', 'this', 'study', 'is', 'now', 'to', 'be', 'extended', 'for', 'a', 'further', '5', 'years', 'with', 'the', 'following', 'objectives', 'in', 'mind:', '1)', 'extending', 'the', 'prevalence', 'estimates', 'to', 'carpal', 'tunnel', 'syndrome', '(CTS),', 'cranial', 'neuropathy', '(CN),', 'proximal', 'asymmetric', 'neuropathy', '(PAN),', 'truncal', 'radiculopathy', '(TR),', 'and', 'autonomic', 'neuropathy', '(AN)', 'and', 'assessing', 'for', 'the', 'prevalence', 'of', 'these', 'neuropathies', 'in', 'a', 'control', 'population;', '2)', 'determining', 'the', 'course', 'of', 'neuropathy', '(and', 'of', 'test', 'results)', 'over', 'a', 'period', 'of', '8', 'years', 'to', 'refine', 'rates', 'of', 'progression', 'and', 'outcome;', '3)', 'validate', 'which', 'minimal', 'criteria', 'for', 'polyneuropathy', '{and', 'also', 'of', 'CTS,', 'CN,', 'PAN,', 'TR,', 'and', 'AN)', 'and', 'criteria', 'for', 'staged', 'severity', 'are', 'best;', 'and', 'especially', '4)', 'critically', 'evaluate', 'the', 'influence', 'of', 'a', 'variety', 'of', 'risk', 'factore', '(serially', 'evaluated', 'cer', 'many', 'years', 'to', 'ensure', 'that', 'they', 'are', 'representative', 'and', 'valid', 'measures)', 'for', 'alterations', 'in', 'staged', 'severity', 'of', 'nevropathy', 'and', 'also', 'for', 'neuropathy', 'test', 'results', '(evaluated', 'over', 'at', 'least', '9', 'years', 'to', 'ensure', 'that', 'a', 'measurable', 'change', 'has', 'occurred', 'in', 'sufficient', 'patients', 'to', 'allow', 'a', 'robust', 'assessment', 'of', 'such', 'risk', 'factors', 'as', 'glycemic', 'control,', 'nephropathy', '(creatinine', 'and', 'microalbuminuria),', 'hypertension', 'and', 'hyperlipidemia', '(cholesterol,', 'triglycerides,', 'lipoproteins,', 'and', 'apolipoproteins).', 'Also', 'to', 'be', 'assessed', 'are', 'whether', 'certain', 'risk', 'factor', 'alterations', 'might', 'predict', 'cardiac', 'death', '(through', 'arhythmia', 'or', 'heart', 'attack),', 'atxoke,', 'CTS,', 'AN,', 'PAN,', 'TR,', 'sexual', 'impotence', 'in', 'the', 'male,', 'Charcot', 'joints,', 'plantar', 'ulcers,', 'or', 'related', 'phenomena.', '6/7/88', 'DIALOG(R)File', '266:Fed.', 'Res.', 'in', 'Progress', '{c)', 'format', 'only', '1995', 'Dialog', 'Info.Sves.', 'All', 'rts.', 'reserv.', 'BESS', 'OFTIS', ' ', ' ']