['PERFORMING', 'ORG.:', 'FRED', 'HUTCHINSON', 'CANCER', 'RESEARCH', 'CENTER,', 'SEATTLE,', 'WASHINGTON', 'SPONSORING', 'ORG.:', 'NATIONAL', 'CANCER', 'INSTITUTE', 'FY', ':', '94', 'FONDS:', '$106,798', 'TYPE', 'OF', 'AWARD:', 'Noncompeting', 'Sootinuation', 'a', '(Type', '5)', 'SGMMARY:', 'DESCRIPTION:', '(Adapted', 'from', 'the', 'Investigator’s', 'Abstract)', 'Smoking', 'is', 'the', 'single', 'largest', 'preventable', 'cause', 'of', 'mortality', 'and', 'morbidity', 'in', 'the', 'United', 'States,', 'Regular', 'smokers', 'who', 'attempt', 'cessation', 'often', 'relapse,', 'and', 'treatment', 'programs', 'have', 'had', 'only', 'modest', 'auccess,', 'which', 'emphasizes', 'the', 'need', 'for', 'more', 'effective', 'smoking', 'cessation', 'techniques.', 'Tryptophan', 'has', 'been', 'used', 'successfully', 'to', 'treat', 'disorders', 'that', 'involve', 'negative', 'affect,', 'such', 'as', '’', 'addition,', 'tryptophan', 'increases', 'brain', 'serotonin,', 'which', 'could', 'prevent', 'increased', 'food', 'consumption', 'and', 'weight', 'gains', 'reported', 'by', 'amokers', 'as', 'a', 'reason', 'for', 'relapse.', 'The', 'proposed', 'study', 'is', 'a', 'randomized,', 'controlled', 'trial', 'to', 'determine', 'the', 'effects', 'of', 'tryptophan', 'as', 'an', 'adjunct', 'to', 'smoking', 'cessation', 'treatment.', 'Subjects', 'will', 'be', 'recruited', 'from', 'the', 'general', 'public', 'who', 'will', 'attend', 'smoking', 'cessation', 'group', 'treatment', 'at', 'the', 'Fred', 'Hutchinson', 'Cancer', 'Research', 'Center.', 'Tryptophan', '(50', 'mg/kg/day)', 'or', 'placebo', 'will', 'be', 'provided', 'to', 'subjects', 'in', 'a', 'double-blind', 'manner.', 'Standard', 'milticomponent', 'cessation', 'groups', 'will', 'consist', 'of', 'eight', 'weekly', 'sessions', 'that', 'include', 'self-management', 'atrategies,', 'knowledge', 'and', 'information,', 'social', 'support,', 'cognitive', 'reatructuring,', 'relaxation', 'training,', 'and', 'relapse', 'prevention', 'training.', 'The', 'primary', 'endpoint', 'will', 'be', 'amoking', 'status', 'at', 'one', 'year', 'after', 'cessation.', 'In', 'addition,', 'smoking', 'status,', 'withdrawal', 'symptoms,', 'patterns', 'of', 'food', 'consumption,', 'and', 'weight', 'gain', 'during', 'the', 'group', 'sessions', 'and', 'at', 'regular', '*', 'status', 'will', 'be', 'verified', 'using', 'biochemical', 'indicators.', 'If', 'effective,', 'tryptophan', 'could', 'be', 'used', 'az', 'a', 'relatively', 'inexpensive,', 'appealing', 'pharmacologic', 'adjunct', 'fox', 'smokers', 'who', 'are', 'trying', 'to', 'quit', 'because', 'of', 'its', 'potential', 'control', 'of', 'withdrawal', 'symptoms', 'and', 'waight', 'gains', 'and', 'because', 'of', 'its', 'minimal', 'negative', 'effects.', '6/7/674', ';', 'DIALOG', '(R)File', '266:Fed.', 'Res.', 'in', 'Progress', '(ce)', 'format', 'only', '1995', 'Dialog', 'Info.Sves,', 'All', 'rta,', 'reserv.', '0119213', 'IDENTIFYING', 'NO.:', 'SR29CA50383-06', 'AGENCY', 'CODE:', 'CRISP', 'FAMILIAL', 'RISK', 'oF', 'LONG', 'CANCER', 'PRINCIPAL', 'INVESTIGATOR:', 'SCHWARTZ,', 'ANN', 'G', 'ADDRESS:', 'UNIVERSITY', 'OF', 'PITTSBURGH', 'SCHOOL', 'OF', 'MEDICINE', 'PITTSBURGH,', 'PA', '15261', 'PERFORMING', 'ORG.:', 'UNIVERSITY', 'OF', 'PITTSBURGH', 'AT', 'PITTSBURGH,', 'PITTSBURGH,', 'PENNSYLVANIA', 'SECU', 'ORT', 'ORG', '=', 'ORG.:', 'NATIONAL', 'CANCER', 'INSTITOTE', 'Fy', ':', '94', 'FONDS:', '$96,599', 'TYPE', 'OF', 'AWARD:', 'Noncompsting', 'Continuation', '(Type', 'SUMMARY:', 'A', 'population-based', 'study', 'of', 'lung', 'cancer', 'risk', 'among', 'relatives', 'of', 'lung', 'cancer', 'cases', 'and', 'controls', 'is', 'proposed.', 'Families', 'of', 'lung', 'cancer', 'patients', 'will', 'be', 'identified', 'through', 'two', 'case', 'series:', '1)', 'non-smoking', 'lung', 'cancer', 'patients', 'aged', '40-84', 'who', 'participated', 'in', 'a', 'previous', 'study', 'of', 'lung', 'eancer', 'risk', 'factors', 'and', '2)', 'newly', 'diagnosed', 'lung', 'cancer', 'patients', 'under', 'the', 'xespiratory', 'diseases', 'also', 'will', 'be', 'investigated.', 'Risks', 'associated', 'with', 'cigarette', 'smoking', 'and', 'occupational', 'exposures', 'will', 'be', 'included', 'in', 'the', 'analysis.', 'Various', 'measures', 'of', 'familial', 'risk', 'will', 'be', 'used', 'in', 'the', 'determination', 'of', 'disease', 'risk', 'among', 'relatives', 'after', 'adjustment', 'for', 'individual', 'risk', 'factors', '(smoking', 'history,', 'age,', 'sex,', 'race,', 'birth', 'cohort,', 'and', 'tG62', 'OPTTS', 'iit,', ' ', ' ', ' ']