[' ', ' ', 'a.', 'Budget', 'revisions', 'for', '19786', 'bh.', 'Research', 'budget', '(1987)', 'completed', 'and', 'submitted', '.', 'c.', 'Work', 'Flan', '(1987)', 'completed', 'and', 'submitted', 'd.', 'Evaluations/training', 'of', 'technical', 'personnel', 'Plan', 'Objective', '5.', 'Neurophysiol', 'ogy', 'of', 'Nicotine', 'Ce', 'peace', 'study', 'on', 'genetic', 'ae', 'of', 'rete', 'of', 'nicotine', 'in', 'stress.', 'ete', 'Boulder.', '“Target', 'date', '4/84)', 'i.', 'Dr.', 'Allan', 'C.', 'Collins', 'was', 'signed', 'on', 'as', 'a', 'neurobiology', 'consultant', 'to', 'the', 'Biobehavioral', 'Division', 'at', 'RdR.', '2.', 'Dr.', 'Collins', 'submitted', 'a', 'proposal', 'to', 'study', 'genetic', 'aspects', 'of', 'the', 'effects', 'of', 'nicotine', 'on', 'stress', 'and', 'learning.', 'Following', 'final', 'input', 'from', 'Biobehavioral', 'personnel', 'an', 'AR', 'was', 'written', 'and', 'the', 'proposal', 'was', 'approved.', 'a.', 'During', 'a', 'trip', 'to', 'Dr.', 'Collins’', '1', 'apprised', 'of', 'the', 'status', 'of', 'the', 'proj', 'results', 'were', 'reviewed', 'and', 'discusse', 'aboratory,', 'Or,', 'Lippiello', 'was', 'ect.', 'The', 'following', 'initial', 'd:', 'a.', 'CEH,', 'DBA,', 'CS7,', 'LS,', 'and', 'SS', 'strains', 'FRRnensive', 'to', 'acute', 'nicotine', 'with', 'res', 'corticesterone', 'levels', 'and', 'ti/S', 'for', 'retu', 'b.', 'Alcchol—-sensitive', 'strains', 'were', 'relatively', 'insensitive', 'to', 'nicotine', 'and', 'vice', 'versa', 'with', 'respect', 'to', 'the', 'coticesterone', 'resnonas,', 'c.', 'Preliminary', 'auwtoradicaqraphic', 'evidence', 'shewed', 'signi', 'differences', 'in', 'nicetine', 'receptor', 'dansities', 'in', 'several', 'r', 'ons', 'ic', 'Drain', 'areas', 'among', 'the', 'strains', 'and', 'dose-related', 'changes', 'in', 'i=', 'oO', 'micetine.', 'd.', 'There', 'were', 'significant', 'differences', 'in', 'hippocampal', '@lectrophysisclegy', 'among', 'the', 'strains', 'in', 'response', 'to', 'nicotine.”', '~', '4.', 'Future', 'studies', 'were', 'planned', 'to', 'sxtend’', 'the', 'above', 'cbservations.', 'Collaborative', 'studies', 'with', 'Dr.', 'Collins', 'were', 'also', 'planned', 'to', 'test', 'the', 'utility', 'of', 'the', 'two-state', 'medel', 'of', 'nicotine', 'receptor', 'binding,', 'developed', 'by', 'Dr.', 'Lippielle,', 'in', 'predicting', 'behavioral', 'responses.', '-', 'ao.', 'Dr.', 'Collins', 'presented', 'his', 'initial', 'findings', 'at', 'the', 'RJR', 'Symposium', 'on', 'Sponsered', 'Nicotine', 'Research.', 'Future', 'directions', 'were', 'planned', 'together', 'with', 'SAB', 'members,', 'in-house', 'personnel,', 'and', 'other', 'contract/collaborative', 'researchers.', '4.7Two', 'publications', 'are', 'in', 'preparation', 'describing', 'Dr.', 'Collins’', 'results', 'om', 'the', 'plasma', 'corticosterone', 'studies.', 'D.', 'Initiate', 'Study', 'of', 'melecular', 'characterization', 'of', 'nicotine', 'revesmeeet', ' meweteumetemesenetanantenmanananasunmaammnaee', '_asaevenenstsasseeeuinmnannetintutenemmmnermssinnenetmesetetesieiitniitnietnie', ' Gasttatint', '—_shtmmewenttetteritnemnee', 'sar', 'receptors', 'in', 'mammalian', 'brain', 'through', 'research', 'aqrant', 'to', 'the', 'ue', 'of', 'Bath,', 'U.K.', '~', '(Target', 'date', '5/84)', '$299', 'L290s', ' ']