[' ', ' ', 'remodeling.', '6/7/766', 'DIALOG(R)', 'File', '266:Fed.', 'Res.', 'in', 'Progress', '{c)', 'format', 'only', '1995', 'Dialog', 'Info.Svcs.', 'All', 'rts.', 'reserv.', '0114018', 'IDENTIFYING', 'NO.:', 'SRO1AR41398-04', 'AGENCY', 'CODE:', 'CRISP', 'Se', 'a', 'wee', 'RISK', 'FACTORS', 'FOR', 'VERTEBRAL', 'FRACTURE', 'AND', 'BONE', 'LOSS', '-', '»)', '>', 'PRINCIPAL', 'INVESTIGATOR:', 'KIEL,', 'DOUGLAS', 'P', '?', 'ADDRESS:', 'HEBREW', 'REHAB', 'CTR', 'FOR', 'AGED', '1200', 'CENTRE', 'STREET', 'BOSTON,', 'MA', '021313', 'PERFORMING', 'ORG.:', 'HEBREW', '$$/REHABILITATION', 'CENTER', 'FOR', 'AGED,', 'BOSTON,', 'SPONSORING', 'ORG.:', 'NAT', 'INST', 'OF', 'ARTHRITIS', 'AND', 'MUSCULOSKELETAL', 'AND', 'SKIN', 'FY', ':', '94', 'FUNDS:', '$290,103', 'TYPE', 'OF', 'AWARD:', 'Noncompeting', 'Continuation', 'SUMMARY:', 'The', 'overall', 'goal', 'of', 'this', 'research', 'is', 'to', 'examine', 'in', 'a', 'population', 'based', 'ccohort', 'of', 'men', 'and', 'women,', 'the', 'Framingham', 'Study,', 'the', 'biologic', 'and', 'behavioral', 'factors', 'asscciated', 'with', 'age-related', 'bone', 'loss', 'from', 'different', 'skeletal', 'sites.', 'The', 'primary', 'cbhjectives', 'are', 'to', 'measure', 'vertebral', 'fracture', 'incidence', 'and', 'changes', 'in', 'metacarpal', 'cortical', 'width', 'in', 'men', 'and', 'women', 'between', 'the', 'year', 'of', '1967~1968,', 'when', 'apinal', 'and', 'hand', 'radiographs', 'were', 'first', 'obtained', 'en', 'cohort', 'participants,', 'and', '1992-1993,', 'when', 'films', 'will', 'be', 'repeated', 'as', 'part', 'of', 'this', 'study.', 'The', 'second', 'objective', 'ia', 'to', 'determine', 'risk', 'factors', '(measured', 'near', 'the', 'time', 'of', 'the', 'initial', 'X-rays)', 'for', 'these', 'vertebral', 'fractures', 'and', 'these', 'changes', 'in', 'metacarpal', 'cortical', 'width.', 'Risk', 'factors', 'will', 'include', 'weight,', 'age', 'of', 'menopause,', 'estrogen', 'use,', 'physical', 'activity', '(leisure', 'and', 'occupational),', 'caffeine,', 'smoking,', 'and', 'alcohol.', 'In', 'addition,', 'the', 'association', 'between', 'vertebral', 'fractures', '/metacarpal', 'cortical', 'width', 'on', 'baseline', 'X-rays', 'this', 'study.', 'Risk', 'factors', 'for', 'this', 'change', 'in', 'BMD', 'will', 'include', 'weight,', 'physical', 'activity', '(leisure),', 'caffeine,', 'smoking,', 'alcohol,', 'thiaride', 'diuretics,', 'teatosterone', 'levels,', 'dietary', 'calcium,', '25', 'hydroxy-vitamin', 'D', 'levels', 'and', 'thyroid', 'hormone', 'xeplacement.', 'and', 'hormone', 'levels.', 'The', 'subjects', 'for', 'this', 'proposal', 'will', 'include', 'all', 'participants', 'in', 'examination', '22', '(1992-1993)', 'of', 'the', 'Framingham', 'Study.', 'At', 'the', 'time', 'of', 'their', 'uaual', 'visit', 'to', 'the', 'Exenivaoan', 'Study,', 'all', 'consenting', 'subjects', 'will', 'undargo', 'a', 'Ado', 'ss)', '3', '3', 'E', 'é', 'c', 'ae', 'ia', 'a.', 'Fs', '*', '5A', 'B', '5', '3', ']', '2', '§', 'S', 'E', 'a', 'measurement', 'issues', 'will', 'be', 'carefully', 'addressed', 'by', 'the', 'combined', 'expertise', 'of', 'the', 'investigative', 'team', 'which', 'includes', 'epidemiologists,', 'experts', 'in', 'bone', 'densitometry,', 'and', 'a', 'skeletal', 'radiologist.', '6/7/767', 'DIALOG(R)File', '266:Fed.', 'Res,', 'in', 'Progress', '(c)', 'format', 'only', '1995', 'Dialog', 'Info.Svea.', 'All', 'rta,', 'raserv.', '0114013', 'IDENTIFYING', 'NO.:', '5RO1AR41366-04', 'AGENCY', 'CODE:', 'CRISP', 'SIOE', 'OPITS', 'PERFORMING', 'ORG.:', 'CHILDREN’S', 'HOSPITAL', 'MED', 'CTR', '(CINCINNATI),', 'CINCINNATI,', ' ']