[' ', 'maternal', 'drug', 'use', 'on', 'parenting,', 'and', 'thereby', 'on', 'child', 'development', 'outcomes,', 'will', 'be', 'also', 'be', 'examined.', ':', 'Simultaneously,', 'Cohort', '2,', 'an', 'additional', 'sample', 'of', '250', 'pre-maritally', 'pregnant', 'young', 'women,', 'will', 'be', 'recruited.', 'Similar', 'measures', 'will', 'be', 'gathered', 'for', 'this', 'cohort.', 'The', 'second', 'cohort', 'will', 'add', 'information', 'on', 'the', 'relationship', 'of', 'parenting', 'attitudes', 'and', 'behavior,', 'child', 'development,', 'maternal', 'verbal', 'ability', 'and', 'Theory', 'of', 'Reasoned', 'Action', 'variables', 'to', 'child', 'development', 'during', 'the', 'child’s', 'first', '3', 'years.', 'In', 'addition,', 'Cohort', '2', 'data', 'will', 'allow', 'tests', 'of', 'hypotheses', 'developed', 'from', 'analyses', 'of', 'cohort', '1', 'data', 'and', 'independent', 'replication', 'of', 'Cohort', '1', 'findings.', 'The', 'findings', 'of', 'this', 'atudy', 'will', 'extend', 'our', 'understanding', 'of', 'both', 'the', 'predictors', 'of', 'drug', 'use', 'among', 'very', 'young', 'mothers', 'and', 'the', 'effects', 'of', 'such', 'drug', 'use', 'on', 'maternal', 'behaviors,', 'mother-child', 'bonding,', 'and', 'child', 'davelopment', '.', '6/7/458', 'DIALOG(R)File', '266:Fed.', 'Res.', 'in', 'Progress', '(c)', 'format', 'only', '1995', 'Dialog', 'Info.Sves.', 'All', 'rts.', 'reserv.', '0124093', 'IDENTIFYING', 'NO.:', '5P50DA05131-06', '0001', 'AGENCY', 'CODE:', 'CRISP', 'BEHAVIORAL', 'GENETIC', 'ANALYSIS', 'OF', 'CIGARETTE', 'WITHDRAWAL', 'PRINCIPAL', 'INVESTIGATOR:', 'WILSON,', 'JAMES', 'R', 'ADDRESS:', 'ONIVERSITY', 'OF', 'COLORADO', 'BOULDER,', 'CO', '80309-0447', 'PERFORMING', 'ORG.:', 'UNIVERSITY', 'OF', 'COLORADO', 'AT', 'BOULDER,', 'BOULDER,', 'COLORADO', 'SPONSORING', 'ORG.:', 'NATIONAL', 'INSTITUTE', 'ON', 'DROG', 'ABUSE', 'FY', ':', '94', '‘TYPE', 'OF', 'AWARD:', 'Noncompeting', 'Continuation', '(Type', '5)', 'SOMMARY:', 'NO', 'SUBPROJECT', 'ABSTRACT', 'AVAILABLE.', 'SEE', 'PARENT', 'GRANT.', '6/7/4589', '-', 'DIALOG{(R)File', '266:Fed.', 'Resa.', 'in', 'Progress', '(c}', 'format', 'only', '1995', 'Dialog', 'Info.Sves.', 'All', 'rts.', 'reserv.', '0124092', 'IDENTIFYING', 'NO.:', 'SP50DA05131-06', 'AGENCY', 'CODE:', 'CRISP', 'BEHAVIORAL', 'GENETIC', 'STUDIES', 'OF', 'DRUG', 'ABUSE', 'VULNERABILITY', 'PRINCIPAL', 'INVESTIGATOR:', 'DE', 'FRIES,', 'JOHN', 'C', 'ADDRESS:', 'UNIVERSITY', 'OF', 'COLORADO', 'BOULDER,', 'CO', '80309-0447', 'PERFORMING', 'ORG.:', 'UNIVERSITY', 'OF', 'COLORADO', 'AT', 'BOULDER,', 'BOULDER,', 'COLORADO', 'SPONSORING', 'ORG.:', 'NATIONAL', 'INSTITUTE', 'ON', 'DROG', 'ABUSE', ',', 'FY', ':', '94', 'FONDS:', '$914,531', 'TYPE', 'OF', 'AWARD:', 'Noncompeting', 'Continuation', 'Type', '5)', 'SUMMARY:', 'The', 'Research', 'Components', 'of', 'this', 'Center', 'include:', '(1)', 'a', 'study', 'of', 'the', 'substance', 'abuse', 'of', 'adolescent', 'children', 'associated', 'with', 'the', 'Colorado', 'Adoption', 'Project;', '(2)', 'study', 'of', 'severe', 'substance-abusing', 'teenagers', 'and', 'their', 'families;', '(3)', 'quantitative', 'genetic', 'analyses', 'of', 'the', 'cigarette', 'withdrawal', 'syndrome;', '(4)', 'assessment', 'of', 'the', 'hypothesis', 'that', 'genetic', 'factors', 'requlate', 'cxtoss-tolerance', 'and', 'dependence', 'between', 'sedative', 'hypnotic', 'drugs', 'based', 'on', 'the', 'lipid', 'solubility', 'of', 'the', 'agents;', 'and', '(5)', 'asaeasament', 'of', 'the', 'tenaion-reduction', 'hypothesis', 'of', 'nicotine’s', 'action', 'and', 'development', 'of', 'animal', 'models', 'of', 'nicotine', 'withdrawal.', '+The', 'research', 'teams', 'will', 'continue', 'to', 'benefit', 'from', 'sharing', 'scientific', 'resources,', 'such', 'as', 'the', 'specific-pathogen-free', 'mouse', 'facility', 'and', 'the', 'twin/adoptee', 'xegisters', 'at', 'IBG;', 'from', 'interactions', 'and', 'exchange', 'of', 'ideas,', '@.g.,', 'comparing', 'results', 'derived', 'from', 'a', 'common', 'database', 'of', 'inbred', 'strains', 'and', 'selected', 'lines', 'of', 'mice', 'to', 'those', 'derived', 'from', 'human', 'subjects;', 'and', 'from', 'enhanced', 'research', 'and', 'administrative', 'assistance.', 'Reaults', 'obtained', 'from', 'research', 'within', 'the', 'Center', 'will', 'continue', 'to', 'contribute', 'to', 'a', 'better', 'understanding', 'of', '-the', 'etiology', 'of', 'individual', 'differences', 'in', 'drug-related', 'behaviors,', 'and', 'will', 'add', 'a', 'valuable', 'increment', 'to', 'the', 'knowledge', 'base', 'for', 'clinical', 'intervention', 'strategies', 'for', 'the', 'individual.', '6/7/460', '51140', '2809', 'ean', ' ']