[' ', '0117711', 'IDENTIFYING', 'NO,:', 'SRO1CA38538-10', 'AGENCY', 'CODE:', 'CRISP', 'MAMMALIAN', 'CELL', 'TRANSFORMATION', 'BY', 'ONCOGENIC', 'VIRUSES', 'PRINCIPAL', 'INVESTIGATOR:', 'FOLK,', 'WILLIAM', 'R', 'ADDRESS:', 'UNIVERSITY', 'OF', 'MISSOURI', 'M121', 'MEDICAL', 'SCIS', 'BUILDING', 'COLUMBIA,', 'MO', 'PERFORMING', 'ORG.:', 'UNIVERSITY', 'OF', 'MISSOURI', 'COLUMBIA,', 'COLUMBIA,', 'MISSOURI', 'SPONSORING', 'ORG.:', 'NATIONAL', 'CANCER', 'INSTITUTE', 'FY', ':', '94', 'FONDS:', '$201,410', 'TYPE', 'OF', 'AWARD:', 'Noncompeting', 'Continuation', 'SUMMARY:', 'DESCRIPTION', '{Adapted', 'from', 'the', 'applicant’s', 'abstract):', 'Aberrant', 'control', 'of', 'the', 'initiation', 'of', 'cellular', 'DNA', 'replication', 'leads', 'to', 'cancer.The', 'purpose', 'of', 'the', 'studies', 'proposed', 'in', 'thia', 'application', 'is', 'to', 'gain', 'Ansight', 'into', 'the', 'molecular', 'mechanisms', 'governing', 'the', 'initiation', 'of', 'DNA', 'replication', 'in', 'mammalian', 'cells,', 'with', 'the', 'expectation', 'that', 'this', 'knowledge', 'will', 'provide', 'the', 'means', 'to', 'reduce', 'proliferation', 'of', 'neoplastic', 'cells.', 'The', 'small', 'DNA', 'tumor', 'viruses', 'provide', 'excellent', 'experimental', 'models', 'with', 'which', 'to', 'study', 'DNA', 'replication', 'in', 'mammalian', 'cells.', 'These', 'viruses', 'depend', 'largely', 'upon', 'cellular', 'machinery', 'to', 'replicate', 'their', 'genomes,', 'and', 'now', 'mich', 'of', 'the', 'biochemistry', 'of', 'the', 'replication', 'complex', 'that', 'is', 'assembled', 'with', 'viral', 'and', 'cellular', 'proteins', 'is', 'understood.', 'However,', 'it', 'is', 'not', 'understood', 'how', 'the', 'assembly', 'of', 'this', 'complex', 'and', 'its', 'subsequent', 'activity', 'is', 'regulated,', 'and', 'this', 'knowledge', 'should', 'provide', 'insights', 'into', 'how', 'cellular', 'replication', 'is', 'regulated.', 'In', 'these', 'studies', 'Dr.', 'Folk', 'proposes', 'to', 'utilize', 'in', 'vitro', 'and', 'in', 'vivo', 'replication', 'assays', 'with', 'purified', 'proteins', 'and', 'DNAs', 'to', 'focus', 'upon', 'two', 'aspects', 'of', 'the', 'regulation', 'of', 'DNA', 'replication', 'of', 'the', 'murine', 'polyomaviruses:', '1)', 'The', 'role', 'of', 'the', 'viral', 'tumor', 'antigens', 'in', 'modifying', 'cellular', 'proteins', 'and', 'cellular', 'signaling', 'pathways', 'to', 'render', 'the', 'host', 'cell', 'permissive', 'for', 'DNA', 'xeplication.', 'In', 'particular,', 'the', 'importance', 'of', 'a', 'novel', 'viral', 'protein', 'containing', 'sequences', 'capable', 'of', 'interacting', 'with', 'DNA', 'polymerase-DNA', 'primase', 'will', 'be', 'explored.', '2)', 'The', 'role', 'of', 'cellular', 'proteins', 'which', 'bind', 'the', 'polyomavirus', 'enhancer', 'in', 'activating', 'the', 'viral', 'origin', 'and', 'the', 'replication', 'complex', 'assembled', 'thereupon.', 'In', 'particular,', 'Dr.', 'Folk', 'will', 'focus', 'upon', 'the', 'AP1', 'protein,', 'which', 'is', 'a', 'paradigm', 'for', 'cellular', 'transcription', 'factors,', 'and', 'ets', 'family', 'proteins', 'binding', 'to', 'the', 'PEA3', 'motif.', '6/7/728', 'DIALOG(R)', 'File', '266:Fed.', 'Res.', 'in', 'Progress', '{c)', 'format', 'only', '1995', 'Dialog', 'Info.Svca.', 'All', 'rts.', 'reserv.', '0117698', 'Pa', 'IDENTIFYING', 'NO.:', '5RO1CA38273-10', 'AGENCY', 'CODE:', 'CRISP', 't”', 'COMMUNITY', 'INTERVENTION', 'TO', 'REDUCE', 'TOBACCO', 'USE', 'PRINCIPAL', 'INVESTIGATOR:', 'BIGLAN,', 'ANTHONY', 'a', 'ADDRESS:', 'OREGON', 'RESEARCH', 'INSTITUTE', '1715', 'FRANKLIN', 'BLVD', 'EUGENE,', 'OREGON', '7403', 'PERFORMING', 'ORG.:', 'OREGON', 'RESEARCH', 'INSTITUTE,', 'EUGENE,', 'OREGON', 'SPONSORING', 'ORG.:', 'NATIONAL', 'CANCER', 'INSTITUTE', 'Fr', ':', '94', 'FUNDS:', '$762,561', 'TYPE', 'OF', 'AWARD:', 'Noncompeting', 'Continuation', '(Type', '5)', 'SUMMARY:', 'This', 'project', 'will', 'develop', 'and', 'experimentally', 'evaluate', 'the', 'effects', 'of', 'a', 'comprehensive', 'smoking', 'prevention', 'program', 'that', 'ia', 'an', 'extensive', 'revision', 'of', 'an', 'existing', 'program.', 'The', 'research', 'has', 'four', 'major', 'aims:', '(1)', 'to', 'compare', 'the', 'effects', 'of', 'the', 'program', 'with', 'a', 'no', 'treatment', 'control', 'condition', 'at', 'the', 'end', 'of', 'one,', 'two,', 'three,', 'and', 'four', 'years', 'of', 'intervention;', '(2)', 'to', ' ', ' ']