['29.', 'KAYAALP,', 'S.', 'O,', 'and', 'McTSAAC,', 'R,', 'J.,', 'PhD,', 'School', 'of', 'Medicine,', 'State', 'University', 'of', 'New', 'York', 'at', 'Buffalo', '"Mascarinic', 'component', 'of', 'splenchnic-sdrenal', 'transmission', 'in', 'the', 'dog."', '(British', 'Journsl', 'of', 'Pharmacology', 'and', 'Chemotherapy', '36/2:', '286-293,', 'June', '1969)', '"The', 'effect', 'of', 'mtropine', 'on', 'catecholamine', 'release', 'evoked', 'by', 'stimu-', 'lation', 'of', 'the', 'splanchnic', 'nerve', 'was', 'studied', 'in', 'the', 'sdrenal', 'medulle', 'of', 'the', 'dog....', '“In', 'three', 'experiments', 'the', 'dogs', 'were', 'treated', 'with', 'nicotine', 'given', 'intravenously', 'in', 'three', 'series', 'of', 'injections....The', 'first', 'series', 'of', 'injections', 'consisted', 'of', 'successive', 'doses', 'of', '1,', '3,', 'and', '3', 'mg/kg', 'of', 'nicotine', 'and', 'caused', 'an', '81-92%', 'reduction', 'of', 'the', 'emount', 'of', 'catecholamines', 'released', 'by', 'nerve', 'stim-', 'lation', 'at', 'different', 'frequencies.', 'The', 'second', 'and', 'third', 'series', 'of', 'nicotine', 'injections,', 'each', 'consisting', 'of', 'two', 'successive', 'doses', 'of', 'nicotine', '5-6', 'mg/ks,', 'did', 'not', 'exert', 'any', 'remarksable', 'change', 'in', 'the', 'residual', 'response', 'to', 'stimulation.', 'Nicotine', 'itself', 'ceused', '&', 'vigorous', 'and', 'sustained', 'release', 'of', 'catecholamines', 'when', 'given', 'at', 'the', 'beginning', 'of', 'the', 'first', 'series.', 'The', 'subsequent', 'injections', 'caused', 'much', 'less', 'release....The', 'adrenal', 'medulla', 'appeared', 'to', 'be', 'completely', 'unresponsive', 'to', 'all', 'injections', 'of', 'the', 'third', 'series', 'end', 'the', 'last', 'injection', 'of', 'the', 'second.', 'The', 'dose-response', 'curve', 'for', 'mdrenaline', 'was', 'not', 'affected', 'by', 'nicotine,', '"Atropine', '(0.3', 'mg/kg', 'intravenously)', 'given', 'epproximetely', '25', 'min', 'after', 'the', 'third', 'serles', 'of', 'nicotlne', 'InjJections', 'caused', '&', 'complete', 'abolition', 'of', 'the', 'response', 'to', '3', 'pulses/sec', 'stimulation,', 'and', 'nearly', 'complete', 'abolition', 'of', 'the', 'responses', 'to', 'stimulstions', 'with', 'higher', 'frequencies', '(P<0,05),', 'Nicow', 'tine', '(5', 'mg/kg', 'intravenously)', 'ceused', 'no', 'release', 'of', 'catecholamines', 'when', 'it', 'was', 'given', 'at', 'the', 'end', 'of', 'the', 'experiment....', '"In', 'conclusion,', 'the', 'results...show', 'that', 'the', 'transmission', 'of', 'impulses', 'from', 'the', 'splanchnic', 'nerve', 'endings', 'to', 'the', 'chromaffin', 'cells', 'mey', 'oceur', 'partly', 'through', 'muscarinic', 'receptors', 'in', 'normal', 'conditlons', 'in', 'the', 'adrenal', 'medulle', 'of', 'the', 'dog,', 'unlike', 'that', 'of', 'the', 'cat.', 'The', 'comparison', 'of', 'the', 'magnitude', 'of', 'the', 'blockede', 'by', 'atropine', 'on', 'the', 'one', 'hand,', 'end', 'by', 'hexa~', 'methonium', 'or', 'nicotine', 'on', 'the', 'other,', 'implies', 'that', 'the', 'involvement', 'of', 'muscarinic', 'receptors', 'in', 'the', 'transmission', 'may', 'be', 'less', 'important', 'than', 'that', 'of', 'nicotinic', 'receptors."', 'LAUSZ,', 'Helena,', 'Acedemy', 'of', 'Medicine,', 'Lodz,', 'Poland', '"Wplyw', 'skladnikow', 'dym', 'tytoniowego', 'na', 'nsblonek', 'migawkowy"', '("The', 'effect', 'of', 'tobacco', 'smoke', 'components', 'on', 'the', 'ciliated', 'epithelium").', '(Otolaryngo-', 'logis', 'Polska', '11/2:', '170-17%,', '1957:', 'Transls.tiong', 'e', 'conducted', 'in', 'situ', 'experiments', 'on', 'the', 'ciliated', 'epithelium', 'of', 'the', 'gullet', 'of', 'the', 'frog.', 'The', 'frogs', 'were', 'decerebrated', 'and', 'the', 'esophagus', 'was', 'sectioned', 'and', 'stretched', 'on', 'a', 'cork.', 'It', 'was', 'cleansed...and', 'the', 'ciliated', 'epithelium', 'was', 'then', 'moistened', 'with', '&', 'few', 'drops', 'of', '[a', 'solution', 'prepared', 'from', 'the', 'mainstream', 'smoke', 'of', '20', 'machine-smoked', 'cigarettes]....', '"We', 'then', 'recorded', 'the', 'time', 'taken', 'by', 'a', 'piece', 'of', 'cork', 'smaller', 'than', '&', 'pinhesd', 'to', 'pass...over', 'a', 'route', '1', 'cm', 'in', 'length.', 'After', 'this', 'norm', 'had', 'been', 'esteblished,', 'the', 'epitheliuvm', 'was', 'moistened', 'with', 'three', 'drops', 'of', 'the', 'tobacco', 'smcke', 'extract,', 'and', 'the', 'time', 'taken', 'o', 'pass', 'over', 'a', 'given', 'route', 'by', 'this', 'same', 'bit', 'of', 'cork', 'was', 'recorded.', 'Fifty', 'frogs', 'were', 'utilized....']