['0124709', 'IDENTIFYING', 'NO.:', 'SRZ29DA048399-02', 'AGENCY', 'CODE:', 'CRISP', 'COCAINE', 'RELAPSE', 'PROCESS', 'PRINCIPAL', 'INVESTIGATOR:', 'MCKAY,', 'JAMES', 'R', 'soa', 'eiga', 'ONIVERSITY', 'OF', 'PENNSYLVANIA', '3900', 'CHESTNUT', 'STREET', 'PHILADELPHIA,', 'PA', '19104-', 'PERFORMING', 'ORG.:', 'UNIVERSITY', 'OF', 'PENNSYLVANIA,', 'PHILADELPHIA,', 'PENNSYLVANIA', 'SPONSORING', 'ORG.:', 'NATIONAL', 'INSTITUTE', 'ON', 'DRUG', 'ABUSE', 'FY', ':', '94', 'FUNDS:', '$103,433', 'TYPE', 'OF', 'AWARD:', 'Noncompeting', 'Continuation', 'SUMMARY:', 'Although', 'primary', 'treatment', 'is', 'generally', 'effective', 'in', 'initially', 'suppressing', 'cocaine', 'use,', 'most', 'cocaine', 'dependent', 'patients', 'begin', 'to', 'abuse', 'cocaine', 'again', 'relatively', 'quickly', 'after', 'treatment', 'has', 'ended.', 'The', 'relapse', 'process', 'has', 'been', 'extensively', 'studied', 'in', 'alcohol', 'abusers', 'and', 'smokera,', 'but', 'comparatively', 'little', 'is', 'known', 'about', 'the', 'factors', 'that', 'lead', 'to', 'cocaine', 'relapse.', 'This', 'propozal', 'is', 'composed', 'of', 'four', 'studies', 'that', 'systematically', 'inveatigate', 'the', 'process', 'of', 'cocaine', 'xelapse.', 'Study', '1', 'involves', 'the', 'development', 'of', 'a', 'structured', 'interview', 'to', 'assess', 'factors', 'involved', 'in', 'the', 'onset,', 'course,', 'and', 'termination', 'of', 'cocaine', 'relapse', 'episodes.', 'A', 'preliminary', 'version', 'of', 'the', 'interview', 'that', 'has', 'already', 'been', 'developed', 'will', 'be', 'refined', 'through', 'further', 'interviews', 'with', 'cocaine', 'dependent', 'patients', 'who', 'have', 'recently', 'relapsed', 'and', 'the', 'test-retest', 'reliability', 'of', 'the', 'completed', 'interview', 'will', 'be', 'evaluated.', 'In', 'Study', '2,', 'the', 'completed', 'Cocaine', 'Relapse', 'Interview', 'will', 'be', 'administered', 'to', 'patients', 'who', 'relapse', 'during', 'a', '5', 'month', 'aftercare', 'txeatment', 'program', 'to', 'investigate', 'the', 'factors', 'underlying', 'cocaine', 'xelapse', 'during', 'aftercare', 'treatment.', 'The', 'concurrent', 'and', 'predictive', 'validity', 'of', 'the', 'interview', 'will', 'also', 'be', 'evaluated', 'in', 'this', 'study.', 'In', 'Study', '3,', 'the', 'interview', 'will', 'be', 'administered', 'to', 'cocaine', 'dependent', 'patients', 'in', 'two', 'samples', 'who', 'relapse', 'during', 'the', 'course', 'of', 'the', 'follow-ups', 'to', 'describe', 'factors', 'involved', 'in', 'relapses', 'that', 'have', 'occurred', 'in', 'the', 'period', 'prior', 'to', 'each', 'follow-up', 'point', '(6,', '12,', '18,', 'and', '24', 'months', 'post', 'intake)', 'and', 'to', 'determine', 'whether', 'there', 'are', 'any', 'patterns', 'in', 'relapse', 'factors', 'over', 'time.', 'Further', 'psychometric', 'evaluation', 'of', 'the', 'interview', 'will', 'also', 'be', 'undertaken', 'during', 'this', 'study', '(i.e.,', 'factor', 'analysis', 'to', 'aid', 'in', 'the', 'construction', 'of', 'subscales).', 'Study', '4', 'will', 'determine', 'whether', 'the', 'specific', 'factors', 'implicated', 'in', 'cocaine', 'relapse', 'episodes', 'can', 'be', 'predicted', 'by', 'within-subject', 'variables', 'and', 'environmental', 'stressors', 'encountered', 'by', 'subjecta', 'prior', 'to', 'their', 'relapse', 'episodes,', 'such', 'as', 'depression,', 'anxiety,', 'low', 'self-efficacy,', 'interpersonal', 'difficulties,', 'lack', 'of', 'social', 'support,', 'and', 'so', 'forth.', 'In', 'Studies', '2-4,', 'additional', 'analyses', 'will', 'also', 'he', 'undertaken', 'to', 'identify', 'factors', 'that', 'differentiate', 'cocalne', '“relapse”', 'from', '“lapse"', 'episodes.', 'The', 'subjects', 'in', 'Study', '1', 'will', 'be', 'recruited', 'from', 'individuals', 'requesting', 'treatment', 'for', 'cocaine', 'dependence', 'at', 'the', 'Treatment', 'Research', 'Unit.', 'The', 'subjects', 'in', 'Studies', '2-4', 'will', 'be', 'patients', 'who', 'are', 'already', 'participating', 'in', 'two', 'studies', 'that', 'are', 'part', 'of', 'a', 'NIDA', 'Center', 'Grant.', '=6/7/414', 'DIALOG', '(R)File', '266:Fed.', 'Rea.', 'in', 'Progress', '(¢).', 'format', 'only', '1995', 'Dialog', 'Info.Svcs.', 'All', 'rts.', 'reserv.', '0124701', '.', 'IDENTIFYING', 'NO.:', '5R01DA08373-062', 'AGENCY', 'CODE:', 'CRISP', ',', 'NEURONAL', 'NICOTINIC', 'RECEPTOR--ASSEMBLY', 'AND', 'REGULATION', 'PRINCIPAL', 'INVESTIGATOR:', 'FORSAYETH,', 'JOHN', 'pte', 'UNIVERSITY', 'OF', 'CALIFORNIA', '513', 'PARNASSUS', 'AVE', 'SAN', 'FRANCISCO,', 'CA', '94143-0584', 'PERFORMING', 'ORG.:', 'UNIVERSITY', 'OF', 'CALIFORNIA', 'SAN', 'FRANCISCO,', 'SAN', 'FRANCISCO,', 'CALIFORNIA', 'SPONSORING', 'ORG.:', 'NATIONAL', 'INSTITUTE', 'ON', 'DRUG', 'ABUSE', 'FY', ':', '94', 'FUNDS:', '$202,985', 'TYPE', 'OF', 'AWARD:', 'Noncompeting', 'Continuation', 'SUMMARY:', 'Nicotine', 'is', 'a', 'powerfully', 'addictive', 'drug', 'and,', 'as', 'the', 'primary', 'pharmacological', 'agent', 'in', 'tobacco', 'products,', 'is', 'the', 'basis', 'of', 'a', 'serious', 'world-wide', 'health', 'problem.', 'Part', 'of', 'the', 'effort', 'against', 'this', 'problem', 'is', 'the', 'attempt', 'to', 'understand', 'the', 'basis', 'of', 'the', 'addictive', 'process.', 'In', 'order', 'to', 'do', 'Pot', ' ', '5114@', '2777', ' ']