['(1.6.,', 'IL-l', 'preduction', 'by', 'monocytes,', 'IL-2', 'production', 'by', 'lymphocytes,', 'iympnocyte', 'proliferative', 'response', 'to', 'PHA,', 'Con', 'A,', 'and', 'PWM,', 'and', 'NK', 'cell', 'cytotoxic', 'activity).', 'The', 'design', 'to', 'be', 'used', 'will', 'increase', 'the', 'reliability', 'of', 'data', 'collected.', 'Because', 'immune', 'system', 'functions', 'and', 'enumerations', 'are', 'influenced', 'by', 'a', 'variety', 'of', 'factors,', 'obtaining', 'a', 'reliable', 'characterization', 'of', 'an', 'individual’s', 'immune', 'status', 'xequirea', 'more', 'than', 'one', 'assessment.', 'Therefore,', 'the', 'reliability', 'of', 'measurement', 'of', 'the', 'neurcendocrine', 'and', 'immne', 'parameters', 'will', 'be', 'improved', 'by', 'assessing', 'subjects', 'twice', 'separated', 'by', '24', 'hours.', 'Subjects', 'for', 'the', 'study', 'will', 'be', 'physically', 'healthy,', 'age-', 'and', 'race-matched', 'women,', 'between', '25', 'and', '50', 'years', 'of', 'age.', 'No', 'depressed', 'patients', 'will', 'be', 'hospitalized', 'and', 'all', 'subjects', 'will', 'be', 'free', 'of', 'medication.', '6/7/77', 'DIALOG(R})File', '266:Fed.', 'Res.', 'in', 'Progress', '(c}', 'format', 'only', '1995', 'Dialog', 'Info.Svca.', 'All', 'rts.', 'reserv.', '0148623', 'IDENTIFYING', 'NO,:', 'SRO1MH49361-02', 'AGENCY', 'CODE:', 'CRISP', 'PRENATAL/EARLY', 'INFANCY', 'PROJECT--A', 'FOLLOW-UP', 'PRINCIPAL', 'INVESTIGATOR:', 'OLDS,', 'DAVID', 'L', 'ADDRESS:', 'UNIV', 'OF', 'ROCHESTER', '601', 'ELMWOOD', 'AVENUE', 'BOX', 'HWH', 'ROCHESTER,', 'NY', '14642', 'PERFORMING', 'ORG.:', 'UNIVERSITY', 'OF', 'ROCHESTER,', 'ROCHESTER,', 'NEW', 'YORK', 'SPONSORING', 'ORG.:', 'NATIONAL', 'INSTITUTE', 'OF', 'MENTAL', 'HEALTH', 'FY', ':', '94', 'FUNDS:', '$441,155', 'TYPE', 'OF', 'AWARD:', 'Koncompeting', 'Continuation', '(Type', '5)', 'SOMMARY:', 'This', 'atudy', 'ass', 'os', 'the', 'long-term', 'effects', 'of', 'an', 'intensive', 'program', 'of', 'prenatal', 'and', 'inf.', 'nurse', 'home', 'visitation', 'on', 'maternal', 'and', 'child', 'development,', 'adjuatment,', 'and', 'competence.', 'The', 'study', 'has', 'two', 'broad', 'aims:', '1)', 'To', 'discern', 'whether', 'the', 'program', 'has', 'an', 'enduring', 'impact', 'on', 'maternal', 'life', 'course', '(fertility,', 'education,', 'work,', 'and', 'reliance', 'on', 'welfare)', 'and', 'child', 'functioning', '(intelligence,', 'school', 'achievement,', 'behavioral', 'adaptation,', 'and', 'emotional', 'adaptation);', 'and', '2)', 'to', 'examine', 'the', 'pathways', 'through', 'which', 'the', 'program', 'affects', 'child', 'outcomes,', 'giving', 'particular', 'attention', 'to', 'maternal', 'life', 'course', 'and', 'caregiving', 'as', 'major', 'mediating', 'processes.', 'With', 'this', 'proposal,', 'we', 'request', 'funds', 'to', 'carry', 'out', 'an', 'assessment', 'of', 'the', 'life-course', 'development', 'of', 'the', 'parents', '(primarily', 'mothers)', 'and', 'their', 'first-born', 'children', 'when', 'they', 'are', '15', 'years', 'of', 'age,', '13', 'years', 'after', 'the', 'program', 'anded.', 'For', 'the', 'mothers,', 'we', 'hypothesize', 'that', 'those', 'who', 'received', 'the', 'prenatal', 'and', 'postpartum', 'nurse', 'visitation', '(and', 'especially', 'those', 'who', 'were', 'from', 'low-income', 'households', 'when', 'they', 'registered', 'in', 'the', 'program', 'during', 'pregnancy),', 'In', 'contrast', 'to', 'their', 'counterparts', 'randomly', 'assigned', 'to', 'comparison', 'services,', 'will', 'have', 'increased', 'labor-force', 'participation;', 'decreased', 'use', 'of', 'AFDC;', 'and', 'fewer', 'subsequent', 'pregnancies.', 'We', 'have', 'predicted,', 'secondarily,', 'that', 'they', 'will', 'have', 'higher', 'standards', 'for', 'their', 'children’s', 'behavior', 'and', 'more', 'consistent', 'enforcement', 'of', 'those', 'standards;', 'reduced', 'rates', 'of', 'child', 'abuse', 'and', 'neglect', 'perpetrated', 'by', 'parents;', 'a', 'greater', 'sense', 'of', 'mastery', 'and', 'control', 'over', 'their', 'life', 'circumstances;', 'lower', 'levels', 'of', 'psychological', 'distress;', 'lower', 'levels', 'of', 'economic', 'and', 'social', 'stress;', 'and', 'greater', 'support', 'from', 'the', 'child’s', 'fathex', 'and', 'their', 'own', 'mothers.', 'For', 'the', 'children,', 'we', 'hypothesize', 'that', 'children', 'born', 'to', 'women', 'who', 'received', 'a', 'nurse', 'beth', 'during', 'pregnancy', 'and', 'the', 'first', 'two', 'years', 'of', 'the', 'child’s', 'life', '(and', 'especially', 'those', 'born', 'to', 'women', 'from', 'low-income', 'households', 'when', 'they', 'registered', 'in', 'the', 'program', 'during', 'pregnancy),', 'in', 'contrast', 'to', 'their', 'counterparts', 'in', 'the', 'comparison', 'groups,', 'will', 'display', 'more', 'competent', 'achool', 'functioning', '{higher', 'achievement', 'scorez', 'in', 'reading', 'and', 'math;', 'better', 'grade-point', 'averages;', 'and', 'fewer', 'cases', 'of', 'grade', 'retention,', 'placement', 'in', 'special', 'educational', 'classes', 'and', 'receipt', 'of', 'special', 'education', 'services);', 'better', 'behavioral', 'adaptation', '(fewer', 'serious', 'behavioral', 'problems,', 'greater', 'social', 'competence,', 'fewer', 'adverse', 'health-related', 'behaviors,', 'and', 'more', 'adaptive', 'pear', 'relations);', 'and', 'better', 'emotional', 'adaptation', '(leas', 'depression', 'and', 'increased', 'perceptions', 'of', 'competence', 'and', 'self-efficacy).', 'Children', 'born', 'to', 'nurse-visited', 'women', 'who', 'amcked', 'cigarettes', 'when', 'they', 'registered', 'in', 'the', 'program', 'during', 'pregnancy,', 'in', 'contrast', 'to', 'their', 'comparison-group', 'counterparts,', 'will', 'have', 'higher', 'IQ', 'scores,', 'school', 'functioning,', 'and', 'fewer', 'behavioral', 'and', 'emotional', 'problems.', '  ', 'oe', '@SSZ', '@PITsS', 'om', ' ', ' ']