['323', 'To', 'determine', 'whether', 'subjects', 'adopted', 'similar', 'smoking', 'and', 'C', 'breathing', 'patterns', 'related', 'to', 'plasma', 'nicotine', 'rise', 'measures,', 'the', 'puffing', 'and', 'breathing', 'parameters', 'for', 'the', '25', 'inhaling', 'subjects', 'were', 'correlated', 'with', 'maximum', 'plasma', 'nicotine', 'rise', 'for', 'the', 'reference', 'and', 'NEW', 'CIGARETTE.', 'None', 'of', 'the', 'breathing', 'measures', 'was', 'significantly', 'correlated', 'with', 'maximum', 'plasma', 'nicotine', 'rise.', 'Table', '10.3.7.3.5.-3.', 'summarizes', 'the', 'puffing', 'parameters', 'correlated', 'with', 'the', 'plasma', 'nicotine', 'measure.', 'For', 'the', 'reference', 'cigarette,', 'only', 'total', 'puff', 'volume', 'was', 'correlated', 'with', 'maximum', 'plasma', 'nicotine', 'rise.', 'For', 'the', 'NEW', 'CIGARETTE,', 'maximum', 'flow', 'rate', 'during', 'a', 'puff', 'was', 'significantly', 'correlated,', 'but', 'in', 'a', 'negative', 'direction.', 'This', 'indicates', 'that', 'the', 'subjects', 'who', 'puffed', 'more', 'intensely', 'exhibited', 'a', 'smaller', 'maximum', 'plasma', 'nicotine', 'rise.', 'These', 'data', 'should', 'not', 'be', 'construed', 'to', 'indicate', 'that', 'the', 'puffing', 'and', 'breathing', 'measures', 'are', 'not', 'important', 'determinants', 'for', 'plasma', 'nicotine', 'rise.', 'Puffing', 'and', 'breathing', 'behaviors', 'may', 'be', 'sufficiently', 'idiosyncratic', 'that', 'systematic', 'relationships', 'between', 'group', 'mean', 'behaviors', 'and', 'group', 'mean', 'plasma', 'nicotine', 'rise', 'are', 'not', 'observable.', 'PUFF', 'PROFILE', 'DATA', 'CORRELATED', 'WITH', 'MAXIMUM', 'PLASMA', 'NICOTINE', 'BOOST', 'URINE', 'MUTAGENICITY', 'GROUPS', '(n=25,', 'INHALING', 'SMOKERS', 'ONLY)', 'CORRELATION', 'COEFFICIENT', '®@', '(PROBABILITY)', 'MAXIMUM', 'DELTA', 'PLASMA', 'WICOTINE', 'CONVENTIONAL', 'NEW', 'PARAMETER', 'ne', 'NUMBER', 'OF', 'PUFFS', '299', '240', '(.07)', '(.12)', 'PUFF', 'VOLUME', '(ml)', '223', '020', '(.14)', '(.46)', 'PUFF', 'FREQUENCY', '(s)', '-.207', '-.135', '(.16)', '(.26)', 'PUFF', 'DURATION', '(s)', '-118', '2312', '(.29)', '(.07)', 'TOTAL', 'PUFF', '485', '*', '-243', 'VOLUME', '(ml)', '(.01)', '(.12)', 'TIME', 'ALIGHT', '(s)', '-', '.030', '-.072', '(.44)', '(.37)', 'ry', 'FLOW', 'RATE', '-025', '~.453', '*', 'DURING', 'PUFF', '(ml/s)', '¢.45)', '(.01)', 'QvPt', 'BZSTS']