['Contract', '15-E', 'Union', 'Carbide', 'Corporation', 'Nuclear', 'Division', 'Oak', 'Ridge,', 'Tennessee', '37830:°', '“', 'Study', 'of', 'the', 'Characterization', 'of', 'Animal', 'Inhalation', 'Exposure', 'Devices', 'andi', 'Dosimetry.', 'The', 'purposes', 'of', 'this', 'program', 'are', 'to', 'carry', 'out', 'research', 'and', 'development', 'and', 'to', 'provide', 'services', 'in', 'three', 'general', 'areas:', 'I.', 'Development', 'of', 'Aerosol', 'Exposure', 'Systems,', 'II.', 'JImhalation', 'Exposure', 'Instrumentation,', 'and', 'III.', 'Technical', 'Services.', 'General', 'experimental', 'approaches', 'and', 'project', 'responsibilities', 'are', 'summarized', 'below.', 'I.', 'IT.', 'Activation', 'Date:', 'June', '1,', '1978', '&', 'pes', 'Current', 'Contract', 'Level:', '$205,000.', 'bob', 'KS', '}é', '1', 'G', 'G-7E', 'Development', 'and', 'Aerosol', 'Exposure', 'Systems.', 'Research', 'and', 'development', 'will', 'be', 'performed', 'to', 'develop', 'systems.', 'to', 'produce', 'and', 'deliver', 'aerosols', 'of', 'bioactive', 'substances', 'as', 'needed', 'for', 'biological', 'testing.', 'Primary', 'emphasis', 'will', 'be', 'given', 'to', 'aerosols.', 'of', 'benzo(a)pyrene', 'and', 'nicotine.', 'The', 'general', 'plan', 'of', 'effort', 'toward', 'development', 'is', 'contained', 'in', 'the', 'following', 'four', 'subtasks:', '(a)', 'Aerosol', 'generation', 'methodology;', '(b)', 'Aerosol', 'delivery', 'and', 'exposure;', '(c):', 'Chemistry', 'and', 'monitoring;', 'and', '(d);', 'Animal', 'effects', 'andi', 'dosimetry.', 'Tobacco', 'Smoke', 'Inhalation', 'Exposure', 'Instrumentation.', 'In', 'most', 'mechanical', 'aspects,', 'the', 'SEM', 'is', 'a', 'state-of-the-art', 'machine.', 'Its', 'operation,', 'however,', 'is', 'controlled', 'rather', 'inflexibly', 'by', 'a', 'mechanical', 'logic', 'system.', 'To', 'demonstrate', 'its', 'utility', 'in', 'delivering', 'smoke', 'in', 'a', 'puff-averaged', 'regimen,', 'the', 'researchers', 'have', 'this', 'year', 'circumvented', 'its', 'mechanical', 'control', 'and', 'replaced', 'it', 'with', 'an', 'electronic', 'programmable', 'controller,', 'achieving', 'a', 'flexibility', 'in', 'operation', 'that', 'should', 'be', 'associated', 'with', 'a', 'research:', 'oriented', 'smoking', 'machine.', 'They', 'propose', 'to', 'extend', 'this', 'concept', 'one', 'step', 'further,', 'placing', 'machine', 'control,', 'data', 'acquistion,', 'and', 'data', 'management', 'under', 'computer', 'control.', 'Technical', 'Services.', 'The', 'contractees', 'shall', 'continue', 'to', 'act', 'in', 'a', 'consulting', 'role', 'on', 'all', 'aspects', 'of', 'dosimetry', 'that', 'are', 'within', 'their', 'areas.', 'of', 'competence.', 'Resources.', 'shall', 'be', 'allocated', 'to', 'perform', 'no', 'more', 'than', 'five', 'smoke', 'dosimetry', 'experiments.', 'As', 'presently', 'planned,', 'three', 'of', 'these', 'shall', 'be', 'a', 'continuation', 'of', 'on-going', 'experiments', 'concerned', 'with', 'changes', 'in', 'deposition', 'of', 'tars', 'that', 'occur', 'during', 'the', 'course', 'of', 'chronic', 'exposures;', 'two', 'will', 'be', 'repeats', 'or', 'reinvestigations', 'of', 'anomalous', 'results', 'on', 'BaP', 'clearance.', 'Services.', 'willl', 'again', 'be', 'supplied', 'to', 'calibrate', 'and', 'maintain', 'monitoring', 'equipment', 'at', 'Microbiological', 'Associates', 'andi', 'also', 'services', 'of', 'a', '"troubleshooting"', 'nature', 'that', 'arise', 'in', 'the', 'course', 'of', 'operations.']