[' ', 'Topic', 'Public', 'Statement', ' ', 'SMOKING', 'AND', 'DISEASE,', '19808', 'NVI:', '$0315.00', ' ', '“Cigarette', 'smoking', 'has', 'not', 'been', 'scientifically', 'established', 'to', 'be', 'a', 'cause', 'of', 'chronic', 'diseases,', 'such', 'as', 'cancer,', 'cardiovascular', 'disease,', 'or', 'emphysema.', 'Nor', 'has', 'it', 'been', 'shown', 'to', 'affect', 'pregnancy', 'outcome', 'adversely."', '—', 'Sheldon', 'Sommers,', 'MD,', 'scientific', 'director', 'of', 'the', 'CTR', 'in', 'congressional', 'testimony,', 'March', '1983.', ' ', ' ', '"Despite', 'intense', 'research', 'over', 'the', 'past', '25', 'years,', 'the', 'biological', 'activity', 'of', 'smoke', 'remains', 'a', 'major', 'challenge.', 'In', 'particular,', 'it', 'is', 'not', 'known', 'in', 'quantitative', 'terms', 'whether', 'the', 'smoke', 'from', 'modern', 'low', 'and', 'ultra-low', 'delivery', 'products', 'has', 'a', 'lower', 'specific', 'biological', 'activity', 'than', 'that', 'from', 'previous', 'high', 'delivery', 'products.', 'Nor', 'is', 'it', 'clearly', 'established', '..', '.', 'what', 'are', 'the', 'main', 'factors', 'that', 'influence', 'biological', '[carcinogenic]', 'activity."', '—', 'Minutes', 'from', 'BAT', 'Research', 'Conference', 'held', 'in', 'Montebello,', 'Quebec,', '1982,', 'prepared', 'by', 'L.C.F.', 'Blackman', 'of', 'BAT', 'R&D.', '"Cigarette', 'brands', 'can', 'be', 'readily', 'distinguished', '[in', 'terms', 'of', 'mutagenicity', 'as', 'judged', 'by', 'an', 'Ames', 'test].', 'This', 'is', 'in', 'contrast', 'with', 'the', 'earlier', 'mouse', 'skin', 'painting', 'results.', 'An', 'unfortunate', 'side-effect', 'is', 'that', 'the', 'sensitivity', 'increases', 'the', 'probability', 'of', 'an', 'Ames', 'League', 'Table', 'appearing.', 'A', 'further', 'unfortunate', 'examination', 'is', 'that,', 'to', 'date,', 'it', 'is', 'not', 'uncommon', 'for', 'BAT', 'brands', 'to', 'have', 'a', 'higher', 'result', '{i.e.,', 'greater', 'mitogenicity]', 'than', 'those', 'from', 'the', 'opposition."', '—', 'Minutes', 'from', 'BAT', 'Biological', 'Conference', 'held', 'in', 'Southampton,', 'England,', '1984,', 'author', 'unknown.']