['\\', '-', 'MEDICAL', 'ARTICLES', 'ON', 'TOBACCO', 'Capsazepine', 'abolishes', 'pulmonary', 'chemoreflexes', 'induced', 'by', 'capsaicin', 'in', 'anesthetized', 'rats.', 'By', 'Lee', 'LY;', 'Lundberg', 'JM', 'Journal', 'of', 'Applied', 'Physiology;', '76', '(5)', 'p1848-1855', 'MAY', '1994', 'ORDER', '#', 'NL970-1', 'Capsaicin', 'stimulates', 'vagal', 'pulmonary', 'C-fiber', 'afferents', 'and', 'elicits', 'pulmonary', 'chemoreflex,', 'characterized', 'by', 'apnea,', 'bradycardia,', 'and', 'hypotension.', 'Similar', 'reflex', 'responses', 'can', 'be', 'also', 'evoked', 'by', 'phenylbiguanide', '(PBG),', 'another', 'potent', 'and', 'commonly', 'used', 'stimulant', 'of', 'these', 'afferents.', 'This', 'study', 'was', 'carried', 'out', 'to', 'determine', 'the', 'effect', 'of', 'capsazepine,', 'a', 'competitive', 'antagonist', 'of', 'capsaicin,', 'on', 'the', 'reflex', 'responses', 'and', 'C-fiber', 'afferent', 'activity', 'evoked', 'by', 'capsaicin', 'and', 'PBG', 'in', 'anesthetized', 'rats.', 'Intravenous', 'infusion', 'of', 'capsazepine', 'did', 'not', 'cause', 'any', 'significant', 'change', 'in', 'the', 'baseline', 'breathing', 'pattern,', 'but', 'it', 'completely', 'abolished', 'the', 'pulmonary', 'chemoreflex', 'elicited', 'by', 'bolus', 'injection', 'of', 'capsaicin', '(1-2', 'mu', 'g/kg', 'iv)', 'and', 'its', 'blocking', 'effect', 'was', 'rapidly', 'reversible.', 'In', 'contrast,', 'the', 'reflex', 'responses', 'to', 'PBG', '(1-4', 'mu', 'g/kg', 'iv)', 'were', 'not', 'altered', 'by', 'capsazepine', 'despite', 'the', 'fact', 'that', 'they', 'could', 'be', 'effectively', 'prevented', 'by', 'the', 'desensitization', 'of', 'C-fiber', 'afferents', 'resulting', 'from', 'a', 'prior', 'capsaicin', 'treatment.', 'Indeed,', 'although', 'both', 'capsaicin', 'and', 'PBC', 'evoked', 'an', 'abrupt', 'and', 'intense', 'burst', 'of', 'discharge', 'from', 'the', 'vagal', 'C-fiber', 'afferent', 'endings', 'in', 'the', 'lungs,', 'the', 'stimulatory', 'effect', 'of', 'the', 'former,', 'but', 'not', 'the', 'latter,', 'was', 'abolished', 'in', 'the', 'same', 'fibers', 'by', 'capsazepine.', 'In', 'summary,', 'capsazepine', 'selectively', 'blocks', 'the', 'stimulatory', 'effect', 'of', 'capsaicin', 'on', 'the', 'vagal', 'C-', 'fiber', 'afferents', 'in', 'the', 'lungs', 'and', 'the', 'consequent', 'pulmonary', 'chemoreflex,', 'presumably', 'by', 'blocking', 'the', 'putative', "'tcapsaicin", 'receptors’‘', 'located', 'in', 'the', 'membrane', 'of', 'these', 'afferent', 'endings.', '(In', 'English)', 'Changes', 'in', 'measurements', 'of', 'body', 'fat', 'distribution', 'accompanying', 'weight', 'change.', 'By', 'Caan', 'B;', 'Armstrong', 'MA;', 'Selby', 'JV;', 'Sadler', 'M;', 'Folsom', 'AR;', 'Jacobs', 'D;', 'Slattery', 'ML;', 'Hilner', 'JE;', 'Roseman', 'J', 'International', 'Journal', 'of', 'Obesity;', '18', '(6)', 'p397-404', 'JUN', '1994', 'ORDER', '#', 'NN366', 'The', 'waist-to-hip', 'circumference', 'ratio', '(WHR),', 'as', 'an', 'indicator', 'of', 'body', 'fat', 'distribution', 'is', 'related', 'to', 'several', 'clinical', 'diseases.', 'Whether', 'one', 'can', 'reduce', 'this', 'ratio', 'with', 'weight', 'loss', 'is', 'still', 'unconfirmed', 'and', 'may', 'differ', 'between', 'sexes.', 'The', 'degree', 'to', 'which', 'WHR', 'changes', 'with', 'weight', 'gain', 'is', 'also', 'unclear.', 'Changes', 'in', 'waist', 'and', 'hip', 'circumferences', 'and', 'WHR', 'accompanying', 'changes', 'in', 'weight', 'over', '5', 'years', 'were', 'examined', 'in', '3,753', 'black', 'and', 'white', 'men', 'and', 'women', 'initially', 'ages', '18-30.', 'Those', 'who', 'gained', 'weight', 'increased', 'their', 'WHR', 'and', 'in', 'most', 'cases', 'those', 'whose', 'weight', 'remained', 'stable', 'increased', 'their', 'WHR.', 'Those', 'who', 'gained', 'the', 'most', 'weight', 'had', 'the', 'greatest', 'increases', 'in', 'WHR.', 'Men', 'had', 'greater', 'increases', 'in', 'WHR', 'per', 'kg', 'weight', 'gain', 'than', 'women.', 'In', 'general,', 'weight', 'loss', 'was', 'accompanied', 'by', 'a', 'decrease', 'in', 'the', 'WHR.', 'However,', 'in', 'those', 'whose', 'initial', 'WHR', 'was', 'below', 'the', 'median,', 'weight', 'loss', 'was', 'associated', 'with', 'an', 'increase', 'in', 'WHR.', 'Smokers', 'and', 'black', 'males', 'also', 'had', 'increases', 'in', 'WHR', 'with', 'weight', 'losses', 'up', 'to', '4.9', 'kg.', '(in', 'English)', 'Vol.', '24,', 'No.', '8,', 'July', '14,', '1994']