['307', 'during', 'the', 'post-39-day', 'NEW', 'CIGARETTE', 'smoking', 'than', 'during', 'the', 'pre-39-day', 'NEW', 'smoking.', 'The', 'total', 'puff', 'volume', 'reflected', 'these', 'behavior', 'patterns,', 'being', 'greater', 'for', 'the', 'NEW', 'CIGARETTE', 'than', 'the', 'reference', 'smoking', 'and', 'greater', 'for', 'the', 'post-39-day', 'NEW', 'CIGARETTE', 'smoking', 'than', 'for', 'the', 'pre-39-day', 'NEW', 'smoking.', 'Average', 'puff', 'volumes', 'were', 'not', 'found', 'to', 'be', 'significantly', 'different.', 'Time', 'alight', 'was', 'less', 'for', 'the', 'post-39-day', 'smoking', 'of', 'the', 'NEW', 'CIGARETTE', 'than', 'for', 'the', 'reference.', 'Repeated', 'measures', 'ANOVA', 'indicated', 'a', 'significant', 'difference', 'among', 'the', 'average', 'puff', 'durations', 'for', 'the', 'three', 'smokings,', 'however,', 'the', 'mean', 'differences', 'among', 'the', 'three', 'groups', 'of', 'data', 'did', 'not', 'exceed', 'the', 'critical', 'value', 'determined', 'from', 'Scheffe’s', 'test', 'at', 'the', 'p', '=', '0.05', 'level.', 'Smokers', 'spent', 'a', 'larger', 'percentage', 'of', 'time', 'alight', 'in', 'puffing', 'while', 'smoking', 'the', 'NEW', 'CIGARETTE.', 'This', 'resulted', 'from', 'the', 'larger', 'number', 'of', 'puffs', 'and', 'smaller', 'time', 'alight', 'observed', 'during', 'smoking', 'the', 'NEW', 'CIGARETTE.', '10.3.7.2.4', 'Breathing', 'Patterns', 'Plasma', 'nicotine', 'profiles', 'for', 'all', '12', 'subjects', 'in', 'the', 'smoking', 'behavior/pharmacokinetic', 'paradigm', 'revealed', 'that', 'two', 'subjects', 'apparently', 'did', 'not', 'inhale,', 'as', 'evidenced', 'by', 'the', 'very', 'small', 'changes', 'in', 'plasma', 'nicotine', 'and', 'concentrations', 'and', '%', 'COHb', 'following', 'smoking', '(see', 'below).', 'An', 'objective', 'of', 'this', 'study', 'was', 'to', 'relate', 'nicotine', 'absorbed', 'from', 'smoking', 'to', 'the', 'puff-profile', 'patterns', 'and', 'smoke', 'inhalation', 'behavior.', 'Therefore,', 'data', 'from', 'these', 'two', 'non-inhaling', 'smokers', 'were', 'not', 'included', 'in', 'this', 'analysis.', 'Although', 'all', 'breaths', 'were', 'monitored', 'for', 'the', 'smoking', 'of', 'the', 'seventh', 'cigarette', 'on', 'each', 'test', 'day,', 'only', 'those', 'breaths', 'immediately', 'following', 'a', 'puff', '(and', 'therefore', 'categorized', 'as', 'smoke-containing', 'inhalations)', 'were', 'analyzed.', 'These', 'data', 'are', 'summarized', 'in', 'Table', '10.3.7.2.4.-1.', 'NEW', 'CIG.', 'NEW', 'CIG.', 'PARAMETER', 'REFERENCE', 'PRE-39-DAYS', ' POST-39-DAYS', 'NUMBER', 'OF', 'BREATHS', '12.7', '16.8', '22.3', '(3.5)', '(8.1)', '(6.5)', 'INSPIRATORY', '801.2', '709.4', '761.0', 'VOLUME', '(m1)', '(361.1)', '(269.3)', '(267.1)', 'TOTAL', 'INSPIRATORY', '10420.', '11092.', '17533.', 'VOLUME', '(m1)', '(5744)', '(4249)', '(10337)', 'INSPIRATORY', 'TIME', '(s)', '1.74', '1.82', '1.51', '(0.79)', '(0.71)', '(0.41)', 'PCV', 'Bests']