['SPONSOR:', 'Lorillard', 'INITIATION', 'DATE:', '07-25-84', 'COMPLETION', 'DATE:', '07-29-84', 'MATERIAL:', 'A-163', 'ISSUE', 'DATE:', '08-24-84', 'SUBJECT:', 'RANGE-FINDING', 'STUDY', 'IN', 'ALBINO', 'RATS', 'WITH', 'A-163:', 'PHASE', 'I', 'Borriston', 'Project', 'No.', '7034(1)', 'FINAL', 'REPORT', 'SUMMARY', 'A', 'range-finding:', 'study', 'was', 'conducted', 'to', 'determine', 'the', 'estimated', 'maximum', 'tolerated', 'dose', '(MTD)', 'level', 'for', 'the', 'test', 'material,', 'A-163.', 'Based', 'on', 'the', 'results', 'of', 'this', 'study,', 'the', 'estimated', 'maximum', 'tolerated', 'dose', 'of', 'A-163', 'is', 'greater', 'than', '5000:', 'mg/Kg,', 'the', 'maximum', 'dose', 'level', 'tested.', 'TEST', 'ARTICLE', 'The', 'test', 'article,', 'A-163,', 'is', 'a', 'clear', 'colorless', 'liquid', 'and', 'was', 'received', 'from', 'the', 'sponsor', 'in', 'amber', 'glass', 'vials', 'on', 'May', '18,', '1984', 'and', 'June', '20,', '1984.', 'The', 'test', 'article', 'was', 'stored', 'under', 'refrigeration', 'in', 'the', 'containers', 'in', 'which', 'it', 'was', 'received.', 'Methylcellulose', '(1%)', 'was', 'used', 'as', 'the', 'vehicle', 'in', 'this', 'study.', 'Stability', 'information', 'is', 'retained', 'by', 'the', 'sponsor.', 'TEST', 'ANIMALS', 'Two', 'male', 'and', 'two', 'female', 'Sprague-Dawley', 'albino', 'rats', 'purchased', 'from.', 'Camm', 'Research', 'Lab', 'Animals.', '(Wayne,', 'New', 'Jersey)', 'were.', 'selected', 'for', 'this', 'study', 'using', 'a', 'random', 'numbers', 'table.', 'Prior', 'to', 'placement’', 'on', 'study,', 'the', 'animals', 'were', 'quarantined', 'for', 'nine.', 'days', 'and', 'observed', 'daily', 'for', 'appearance', 'and', 'behavior.', 'The', 'animals', 'were', 'individually', 'housed', 'in.', 'suspended', 'stainless', 'steel', 'cages', 'with', 'wire', 'mesh', 'bottoms', 'and', 'non-contact', 'paper', 'for', 'bedding.', 'Purina®', 'Rodent', 'Laboratory', '.', 'SO6E9EES']