[' ', ' ', 'nonlinear', '10-12', ' ', ' ', ' ', ' ', ' ', ' ', ' ', 'Free', 'Radicals', 'In', 'addition', 'to', 'a', 'reduced', 'intake', 'of', 'dietary', 'anti-oxidants,', 'smokers', 'are', 'also', 'exposed', 'to', 'free', 'radicals', 'from', 'both', 'cigarette', 'smoke', 'and', 'increased', 'pulmonary', 'inflammation', '(Pittilo', 'and', 'Woolf,', '1994).', 'The', 'possible', 'importance', 'of', 'free', 'radicals', 'in', 'cardiovascular', 'health', 'was', 'demonstrated', 'by', 'improvement', 'in', 'endothelium-dependent', 'vasomotion', 'with', 'cholesterol-', 'lowering', 'antioxidant', 'therapy', '(Anderson', 'et', 'al.,', '1995).', '“Is', 'clinically', 'significant', 'thrombus', 'formation', 'induced', 'by', '‘real-world’', 'ETS', 'levels?”', 'Possible', 'Influence', 'of', 'Lifestyle', 'on', 'Thrombogenesis', 'Lifestyle', 'is', 'usually', 'considered', 'in', 'regard', 'to', 'atherosclerosis', 'because', 'of', 'potential', 'effects', 'on', 'cholesterol', 'metabolism.', 'However,', 'we', 'have', 'collected', 'preliminary', 'evidence', 'which', 'suggests', 'that', 'lifestyle', 'may', 'also', 'influence', 'the', 'tendency', 'toward', 'thrombogenesis.', 'In', 'an', 'intensive', 'hematologic', 'study', 'on', 'healthy', 'subjects', 'following', 'lifestyles', 'with', 'minimal', 'cardiovascular', 'risk', 'factors', 'other', 'than', 'smoking,', 'thrombogenic', 'risk', 'was', 'less', 'than', 'that', 'previously', 'reported', 'for', 'smokers', '(McKarns', 'ef', 'a/.,', '1995).', 'While', 'some', 'cardiovascular', 'risk', 'factor', 'increases', 'in', 'the', 'smokers', 'were', 'noted,', 'they', 'were', 'smaller', 'than', 'previously', 'reported,', 'Among', 'males,', 'the', 'following', 'differences', 'between', 'smokers', 'and', 'nonsmokers', 'were', 'noted:', 'white', 'blood', 'cell', 'counts,', '+26%;', 'fibrinogen', 'levels,', '+17%;', 'mean', 'corpuscular', 'hemoglobin,', '+5%;', 'mean', 'corpuscular', 'volume,', '+4%.', 'In', 'addition,', 'prothrombin', 'time', 'was', 'decreased', 'by', '5%.', 'Among', 'females,', 'the', 'only', 'thrombogenic', 'risk', 'factor', 'which', 'differed', 'significantly', 'was', 'the', 'white', 'blood', 'cell', 'count,', '+43%', 'in', 'the', 'smokers.', 'In', 'this', 'study', 'no', 'atherogenic', 'risk', 'factor', 'differed', 'between', 'smokers', 'and', 'nonsmokers', 'including', 'cholesterol,', 'low-density', 'lipoprotein,', 'high-density', 'lipoprotein,', 'very', 'low-density', 'lipoprotein,', ' ', 'L?6e', 'ElLBCS', ' ']