['Grant', '120]', 'Louis', 'A.', 'Soloff,', 'M.D.', 'Distinguished', 'Professor', 'of', 'the', 'University', 'Director,', 'Lipid', 'Research', 'Laboratory', 'Division', 'of', 'Cardiology', '~-', 'Temple', 'University', 'Health', 'Sciences', 'Center', '3401', 'North', 'Broad', 'Street', '-', 'Philadelphia,', 'Pennsyivania', '19140', 'The', 'Role', 'of', 'Lecithin', 'Cholesterol', 'Acyltransferase', '(ICAT)', 'in', 'Cholesterol', 'Transport', 'to', 'and', 'from', 'Peripheral', 'Tissues', 'and', 'its', 'Modification', 'by', 'Smoking.', '.', 'The', 'overall', 'goal', 'of', 'this', 'study', 'is', 'to', 'further', 'the', 'understanding', 'of', 'human', 'cholesterol', 'metabolism', 'by', 'immunoassay', 'of', 'the', 'enzyme', 'lecithin', 'cholesterol', 'acyltransferase', '(LCAT)', 'and', 'an', 'assay', 'of', 'cholesterol', 'esterification', 'in', 'the', 'fasting', 'and', 'fedi', 'states.', 'Studies', 'will', 'be', 'carried', 'out', 'in', 'the', 'fasting', 'state', 'and', 'also', 'after', 'a', 'breakfast', 'containing', 'food', 'predominantly', 'rich', 'in', 'saturated', 'fatty', 'acids,', 'floods', 'predominantly', 'rich', 'in', 'unsaturated', 'fatty', 'acids', 'and’', 'foods', 'predominantly', 'rich', 'in', 'carbohydrates.', 'These', 'two', 'assays', 'should', 'permit', 'the', 'distinction', 'of', 'the', 'contribution', 'of', 'the', 'enzyme', 'proper', 'to', 'LCAT', 'activity', 'from', 'contribution', 'of', 'the', 'enzyme', 'substrates,', 'activators', 'and', 'inhibitors', 'of', 'LCAT', 'activity.', 'This', 'enzyme', 'is', 'essential', 'for', 'human', 'plasma', 'esterification', 'and', 'directly', 'and', 'indirectly', 'for', 'the', 'production', 'of', 'normal', 'plasma', 'lipoproteins.', 'Since', 'involvement', 'of', 'lipoproteins', 'and', 'lipoprotein', 'cholesterol', 'in', 'atherosclerosis', 'andi', 'other', 'lipid', 'disorders', 'has', 'been', 'amply', 'documentedi,', 'the', 'results', 'of', 'these', 'studies', 'should', 'contribute', 'to', 'the', 'overall', 'understanding', 'of', 'the', 'mechanisms', 'andi', 'pathogenesis', 'of', 'these', 'disorders', 'and', 'to', 'the', 'development', 'cf', 'improvements', 'in', 'the', 'prognosis,', 'diagnosis,', 'and', 'hopefully', 'in', 'the', 'treatment', 'of', 'atherosclerosis,', 'complications', 'of', 'which', 'are', 'the', 'commonest', 'cause', 'of', 'death', 'in', 'adults.', 'in', 'our', 'society.', 'At', 'the', 'present', 'time,', 'the', 'investigators', 'have', 'performed', 'these', 'two', 'assays', 'in', 'arterial', 'bloodi,', 'systemic', 'vein,', 'hepatic', 'vein', 'and', 'lymph;', 'but', 'the', 'number', 'of', 'studies', 'is', 'not', 'sufficient.', 'to', 'determine', 'their', 'statistical', 'significance.', 'Activation', 'Date:', 'July', '1,', '1978', 'Current', 'Grant', 'Level:', '$59,464.', 'QO', "'", 'N', 'oo', 'f6EPTPTO']