['RATIONALE:', '6.', 'Ascertain', 'the', 'utility', 'of', 'clinical', 'chemical', 'data', 'and', 'advanced', 'pathology', 'methods', 'for', 'assessing', 'dose', 'susceptibility', 'and', 'respira-', 'tory', 'disease', 'states', 'including', 'lung', 'cancer.', '7.', 'Support', 'and', 'supply', 'appropriate', '"state-of-', "the-art''", 'hardware', 'and', 'instrumentation', 'in', 'the', 'chemical', 'study', 'of', 'smoke', 'aerosols', 'and', 'in', 'the', 'bioanalytical', 'methods', 'development.', 'Assure', 'the', 'performance', 'and', 'maintenance', 'of', 'inhalation', 'exposure', 'machines,', 'animal', 'containment', 'devices,', 'exposure', 'chamber', 'monitors,', 'tracheal', 'transplant', 'exposure', 'devices,', 'etc.', '8.', 'Provide', 'direct', 'support', 'to', 'other', 'NCI', 'contractors', 'in', 'implementing', 'procedures', 'and', 'applying', 'hardware', 'developed', 'by', 'Oak', 'Ridge', 'National', 'Laboratory', 'and', 'support', 'other', 'contractors', 'with', 'Special', 'Services', 'requested', 'by', 'the', 'National', 'Cancer', 'Institute.', '9.', 'Through', 'exposure', 'chemistry', 'determine', 'relevance', 'of', 'smoke', 'aerosol', 'offered', 'animals,', 'measure', 'the', 'dose', 'of', 'actual', 'smoke', 'constituents', 'by', 'chamber', 'depletion', 'analysis', 'or', 'other', 'means,', 'and', 'monitor', 'performance', 'of', 'equipment', 'used', 'in', 'chronic', 'exposure', 'experi-', 'ments', 'by', 'Oak', 'Ridge', 'National', 'Laboratory', 'and', 'other', 'contractors.', 'Project', 'will', 'accelerate', 'the', 'trend', 'towards', 'inhalation', 'bioassay', 'which', 'is', 'a', 'more', 'realistic', 'model', 'of', 'lung', 'cancer', 'hazards', 'than', 'mouse', 'skin', 'painting', 'and', 'also', 'gives', 'an', 'opportunity', 'to', 'study', 'other', 'pulmonary', 'and', 'systemic', 'effects.', 'Techniques', 'for', 'inhalation', 'exposure', 'of', 'all', 'animal', 'models', 'require', 'additional', 'develop-', 'ment', 'and', 'standardization', 'for', 'routine', 'use', 'as', 'an', 'investigating', 'tool.', 'This', 'project', 'is', 'directed', 'at', 'developing', 'the', 'equipment', 'and', 'methodology', 'required', 'for', 'inhalation', 'bioassay', 'in', 'rats', 'and', 'hamsters.', 'TIMN', '422189']