[' ', ' ', ' ', 'ley', '£8', 'naga}', 'abnormabties', 'Suspicious', 'tissues', 'were', 'examined', 'as', 'to', 'type', 'and', 'cataloged', 'with', 'respect', 'to', 'incidence,', 'Evaluation', 'of', 'the', 'Data.', 'Tumor', 'incidences', 'in', 'treated', 'versus', 'the', 'appropriate', 'vehicle', 'control', 'animals', 'were', 'compared', 'by', 'the', 'standard', 'x?', 'test', 'to', 'determine', 'whether', 'each', 'compound', 'was', 'positive.', 'In', 'addition,', 'the', 'method', 'of', 'Zweifel', '(22),', 'previously', 'applied', 'to', 'pulmonary', 'tumor', 'data', 'by', 'Shimkin', 'ef', 'al.', '(15),', 'was', 'used', 'to', 'express', 'the', 'relative', 'potency', 'of', 'the', 'more', 'reactive', 'compounds.', 'RESULTS', 'Pulmonary', 'Tumors', 'in', 'Untreated,', 'Vehicle', 'and', 'Urethan-', 'treated', 'A/He', 'Mice.', 'Table', '2', 'presents', 'data', 'on', 'the', 'occurrence', 'of', 'pulmonary', 'tumors', 'in', 'A/He', 'mice', 'of', 'both', 'sexes', 'that', 'received', 'either', 'no', 'treatment,', '24', 'thrice', 'weekly', 'injections', 'of', 'the', 'vehicles', 'used', 'for', 'the', 'food', 'additives', 'and', 'chemotherapeutic', 'compounds,', 'water,', 'SSV', 'and', 'tricaprylin', '(2097', 'and', 'X2097),', 'or', 'a', 'single', 'ip.', 'injection', 'of', 'urethan', '(10', 'or', '20', 'mg/mouse).', 'Since', 'only', 'female', 'mice', 'were', 'used', 'in', 'early', 'experiments', 'with', 'the', 'impure', 'lot', 'of', 'tricaprylin', '(2097),', 'vehicle', 'data', 'were', 'obtained', 'also', 'from', 'females', 'only.', 'Data', 'are', 'given', 'on', 'the', 'tumor', 'response', 'of', 'mice', ' ', 'Carcinogenicity', 'of', 'Pood', 'Additives', 'and', 'Drag', 'that', 'received', 'only', '6', 'of', '12', 'ip.', 'injections', 'of', 'SSV,', '10', 'permit', 'comparison', 'with', 'the', 'tumor', 'response', 'of', 'animals', 'that', 'received', 'fewer', 'than', '24', 'injections', 'of', 'the', 'chemotherapculic', 'compounds.', 'Untreated,', 'vehicle-treated,', 'and', 'urethan-treated', 'mice,', 'kept', 'in', 'parallel', 'with', 'the', 'experimental', 'groups,', 'were', 'killed', 'at', '24', 'weeks', 'after', 'the', 'initiation', 'of', 'the', 'experiments.', 'Data', 'on', 'untreated', 'animals', 'represent', 'the', '“spontaneous”', '‘ung', 'tumor', 'incidence', 'in', 'A/He', 'mice', 'and', 'are', 'in', 'close', 'accord', 'with', 'earlier', 'data', 'on', 'mice', 'of', 'equivalent', 'age', '(15,', '16,', '20).', 'Asin', 'these', 'earlier', 'studies,', 'males', 'have', 'a', 'slightly', 'higher', 'tumor', 'incidence', 'than', 'females', '(0.22', 'versus', '0.17', 'tumor/mouse).', 'The', 'conclusion', 'reached', 'in', 'the', 'literature', 'is', 'that', 'there', 'is', 'no', 'important', 'sex', 'difference', 'in', 'tumor', 'incidence,', 'however,', 'the', 'consistently', 'higher', 'response', 'in', 'males', 'indicates', 'that', 'the', 'difference', 'is', 'real', 'and', 'is', 'due', 'to', 'some', 'unknown', 'sex-linked', 'factors.', 'Results', 'obtained', 'with', 'the', 'vehicle', 'controls', 'show', 'that', 'the', 'occurrence', 'of', 'lung', 'tumors', 'was', 'not', 'affected', 'significantly', 'by', 'the', 'injections.', 'There', 'were', 'slight', 'increases', 'in', 'tumor', 'incidence', 'among', 'most', 'vehicle', 'controls,', 'and', 'a', 'considerably', 'higher', 'incidence', '(mean', 'tumor', 'value,', '0.59/mouse)', 'in', 'tricaprylin', '2097-treated', 'animals,', 'but', 'these', 'were', 'not', 'statistically', 'signifi-', 'Table', '2', 'Pulmonary', 'tumors', 'in', 'untreated,', 'vehicte-treated', 'and', 'urethan-treated', 'Alife', 'mice', 'AjHe', 'mice', 'were', 'either', 'untreated', 'or', 'received', 'O.I-mli.p.', 'injections', 'of', 'water,', 'tricaprylin', '(2097', 'and', 'X2097}', 'and', 'SSV,', 'on', 'the', 'positive', 'carcinogen,', 'urethan,', 'The', 'animals', 'were', 'killed', 'after', 'a', 'total', 'of', '24', 'weeks', 'and', 'their', 'lungs', 'were', 'removed', 'and', 'placed', 'in', 'Tellyesniczky’s', 'fluid.', 'After', 'fixation,', 'the', 'surface', 'tumors', 'were', 'counted:', 'the', 'data', 'are', 'expressed', 'as', 'mean', 'number', 'of', 'tumors', 'per', 'mouse.', ' ', ' ', ' ', ' ', 'Mice', 'Duration', 'with', 'of', 'ex-', 'No.', 'of', 'lung', 'No.', 'of', 'periment', 'ip.', 'an-', 'Survivors/', 'tumors', 'tumors}', 'Treatment', '(wk)', 'injections', 'Sex', 'initial', '(%)', 'mouse', 'Untreated', '24', '0', 'M', '46/50', '22', '0.22', '2', '0.03%', 'F', '48/50', '17', '0.17', ':', '0.62', 'Vehicle', 'Water', '24', '24', 'M', '30/30', '27', '0.27', '2', '0.05', 'F', '28/30', 'cd', '0.37:', '0.07', 'Tricaprylin', '24', '24', 'F', '22/25', '45', '0.592', '0.13', '2097', 'Tricaprybn', '24', '24', 'M', '711/80', '28', '0.242003', 'X2097', 'F', '77/80', '20', '0.20:', '0.02', 'SSV', '24', '24', 'M', '28/30', '26', '0.25', ':', '0.05', 'F', '30/30', '3', '0.231004', 'Ssv', 'Pe]', '12', 'M', '28/30', '22', '0.22', '0.04', 'F', '30/30', '20', '0.19', '2', '0.04', 'SSV', '24', '6', 'M', '26/30', '9', '0.23', '+', '0', '04', 'f', '26/30', '18', '0.172', '0.04', 'Urethan', '10', 'mg', 'a4', "'", 'M', '20/20', '100', '10.5', '22.30', 'F', '20/20', '100', '9.1', '+', '2.28', '20', 'mg', 'uM', "'", 'M', '20/20', '100', '21.8', '24.48', 'F', '19/20', '100', '19.6', '+', '4.20', 'a', '©', 'Mesn:', 'SE', 'DECEMBER', '1973', '3071', 'fae', 'hak', 'bedbefieas', 'eerie', 'ots', 'on', 'cad', ' ', ' ', 'G@ST', '9OOTS']