['06-23-93', 'Bage', '-46-', 'Oxidation', 'Of', 'Benzaldehydes', 'To', 'Benzoic', 'Acid', 'Derivatives', 'By', 'Three', 'Desulfovibrio', 'Strains.', 'By', 'Zellner,', 'G.;', 'Kneifel,', 'H.;', 'Winter,', 'J.', 'In', 'English', 'APPL.', 'ENVIRON.', 'MICROBIOL.', '56(7),', 'pp.', '2228-2233', '1990', '.', '[<DIALOG>', '1588134]', 'ABSTRACT>', 'Desulfovibrio', 'vulgaris', 'Marburg,', '"Desulfovibrio', 'simplex', 'XVI,', 'and', 'Desulfovibrio', 'sp.', 'strain', 'MP47', 'used', 'benzgaldehydes', 'such', 'as', 'vanillin,', '3,', '4,5-trimethoxybenzaldehyde,', 'protocatechualdehyde,', 'syringaldehyde,', 'p-', 'anisaldehyde,', 'p-hydroxybenzaldehyde,', 'and', '2-methoxybenzaldehyde', 'as', 'electron', 'donors', 'for', 'sulfate', 'reduction', 'and', 'carbon', 'dioxide', 'and/or', 'components', 'of', 'yeast', 'extract', 'as', 'carbon', 'sources', 'for', 'cell', 'synthesis.', 'The', 'aldehydes', 'were', 'oxidized', 'to', 'their', 'corresponding', 'benzoic', 'acids.', 'The', 'three', 'sulfate', 'reducers', 'oxidized', 'up', 'to', '7', 'mM', 'vanillin', 'and', 'up', 'to', '4', 'mM', 'p-anisaldehyde.', 'Higher', 'concentrations', 'of', 'vanillin', 'or', 'p-', 'anisaldehyde', 'were', 'toxic.', 'In', 'addition,', 'pyridoxal', 'hydrochloride', 'and', 'o-', 'vanillin', 'served', 'as', 'electron', 'donors', 'for', 'sulfate', 'reduction.', 'Salicylaldehyde,', 'pyridine-2-aldehyde,', 'pyridine-4-aldehyde,', 'and', '4-', 'hydroxy-3-methoxybenzyl', 'alcohol', 'were', 'not', 'oxidized.', 'No', 'molecular', 'hydrogen', 'was', 'detected', 'in', 'the', 'gas', 'phase.', 'The', 'oxidized', 'aldehydes', 'were', 'not', 'further', 'degraded.', 'Identification', 'Of', 'The', 'Mouse', 'Aldehyde', 'Dehydrogenases', 'Important', 'In', 'Aldophosphamide', 'Detoxification.', 'By', 'Manthey,', 'C.L.;', 'Landkamer,', 'G.J.;', 'Sladek,', 'N.E.', 'In', 'English', 'CANCER', 'RES.', '50(16),', 'pp.', '4991-5002', '1990', '[<DIALOG>', '1552579]', 'ABSTRACT>', 'Aldophosphamide,', 'the', 'penultimate', 'cytotoxic', 'metabolite', 'of', 'cyclophosphamide,', 'can', 'be', 'detoxified', 'by', 'an', 'oxidation', 'reaction', 'catalyzed', 'by', 'certain', 'aldehyde', 'dehydrogenases.', 'The', 'selective', 'toxicity', 'of', 'cyclophosphamide', 'is', 'due,', 'at', 'least', 'in', 'part,', 'to', 'a', 'greater', 'expression', 'of', 'the', 'relevant', 'aldehyde', 'dehydrogenase', 'activity', 'in', 'normal', 'cells', 'relative', 'to', 'that', 'expressed', 'in', 'certain', 'tumor', 'cells.', 'Not', 'known', 'at', 'the', 'onset', 'of', 'this', 'investigation', 'was', 'which', 'of', 'the', 'several', 'known', 'mouse', 'aldehyde', 'dehydrogenases', 'catalyze', 'this', 'reaction.', 'Twelve', 'enzymes', 'that', 'catalyze', 'the', 'NAD(P)-linked', 'oxidation', 'of', 'aldophosphamide,', 'acetaldehyde,', 'benzaldehyde,', 'and/or', 'octanal', 'were', 'chromatographically', 'resolved', 'from', 'mouse', 'liver.', 'Of', 'all', 'the', 'aldehyde', 'dehydrogenases', 'examined,', 'AHD-2', 'and', 'AHD-8', 'were', 'estimated', 'to', 'be', 'the', 'most', 'efficient', 'catalysts', 'of', 'aldophosphamide', 'oxidation.', 'Thus,', 'these', 'enzymes', 'would', 'seem', 'most', 'likely', 'to', 'be', 'operative', 'when', 'tumor', 'cells', 'acquire', 'aldehyde', 'dehydrogenase-mediated', 'cyclophosphamide', 'resistance.', '88704904']