['January', '3.', '1983', 'THE', 'Councit', 'For', 'Tobacco', 'RESEaARCH-', 'U:S.A.,', 'INC.', 'PUBLICATION', 'BY', 'GRANTES', '(2091)', 'The', 'following', 'paver', 'has', 'been', 'published', 'with', 'acknowledgment', 'of', 'support', 'by', 'The', 'Council', 'for', 'Tobacco:', 'Research', '-', 'U.S', 'A.,', 'Ine.', 'EFFECTS', 'OF', 'ACUTE', 'CENTRAL', 'AND', 'PERIPHERAL', 'ADMINISTRATION', 'OF', 'NICOTINE', 'ON', 'HYPOTHALAMIC', 'CATECHOLAMINE', 'NERVE', 'TERMINAL', 'SYSTEMS', 'AND', 'ON', 'THE', 'SECRETION', 'OF', 'ADENOHYPOPHYSEAL', 'HOR-', 'MONES', 'IN', 'THE', 'MALE', 'RAT', 'The', 'actions', 'of', 'intraventricular', 'injections', 'and', 'intravenous', 'infusions', 'of', 'nicotine', 'were', 'evaluated', 'on', 'dopamine', 'and', 'noradrenaline', 'stores', 'and', 'turnover', 'in', 'discrete', 'hypothalamic', 'dopamine', 'and', 'noradrenaline', 'nerve', 'terminal', 'systems', 'in', 'male', 'Sprague-Daw-', 'ley', 'rats.', 'Anterior', 'pituitary', 'hormone', 'secretion', 'was', 'also', 'studied', 'in', 'the', 'same', 'group', 'of', 'animals.', 'Specifically,', 'measurements', 'were', 'made', 'of', 'LH,', 'FSH,', 'GH,', 'TSH,', 'prolactin', 'and', 'corticosterone', 'serum', 'levels', 'using', 'radioimmunological', 'procedures.', 'Intraindividual', 'correlations', 'between', 'regional', 'catecholamine', 'levels', 'and', 'turnover', 'and', 'hormone', 'secretion', 'were', 'performed,', 'Results', 'showed', 'that', 'intraventricular', 'injections', 'of', 'nicotine', 'produced', 'dose-dependent.', 'reductions', 'of', 'dopamine', 'and', 'noradrenaline', 'levels', 'and', 'increases', 'of', 'dopa-', 'mine', 'and', 'noradrenaline', 'turnover', 'in', 'discrete', 'hypothalamic', 'areas.', 'The', 'turnover', 'increases', '_were', 'associated', 'with', 'reductions', 'of', 'serum', 'levels', 'of', 'TSH,', 'prolactin', 'and', 'LH', 'and', 'an', 'increase', 'of', 'serum', 'FSH', 'levels.', 'Correlation', 'analysis', 'in', 'the', 'intraventricular', 'experiments', 'was', 'performed.', 'Also,', 'intravenous', 'infusions', 'of', 'nicotine', 'over', 'one', 'hour', 'produced', 'dose-dependent', 'reduction', 'of', 'dopamine', 'and', 'noradrenaline', 'concentrations', 'and', 'increased', 'the', 'turnover', 'of', 'these', 'ne', 'in', 'the', 'various', 'hypothalamic', 'catecholamine', 'nerve', 'terminal', 'systems', 'analyzed,', 'with', 'the', 'median', 'eminence,', 'dopamine', 'and', 'noradrenaline', 'nerve', 'terminal', 'sys-', 'tems', 'showing', 'the', 'highest', 'sensitivity', 'to', 'nicotine,', 'Overall,', 'the', 'total', 'of', 'these', 'and', 'other', 'experimental', 'findings', 'reinforces.the', 'view', 'that', 'nicotine', 'may', 'act', 'directly', 'on.', 'the', 'brain', 'to:', 'activate', 'dopamine', 'and', 'noradrenaline', 'nerve', 'terminal', 'systems,', 'probably', 'via', 'ac-', 'tivation', 'of', 'nicotine-like', 'cholinergic', 'receptors.', 'Correlation', 'analysis', 'shows:', 'that.', 'other', 'neurotransmitter', 'mechanisms.', 'must', 'also', 'be', 'involved', 'in', 'producing', 'the', 'nicotine-induced', '96ESSOSTO”', 'changes', 'in', 'the', 'secretion', 'of', 'anterior', 'pituitary', 'hormones.', 'Andersson,', 'K.,', 'Fuxe,', 'K.', '(1223),', 'HEneroth,', 'P.,', 'and', 'Agnati,', 'L.', 'F.', 'Medical', 'Biology', '60:98-111,', '1982.', 'Other', 'support:', 'Svenska', 'Tobaks', 'AB,', 'Stockholm.', 'From', 'the', 'Dept.', 'of', 'Histology,', 'Karolinska', 'Institutet', 'and', 'the', 'Hormone', 'Laboratory,', 'Karolinska', 'Hospital,', 'Stockholm:', 'and', 'the', 'Dept.', 'of', 'Human', 'Physiology,', 'University', 'of', 'Modena,', 'Modena,', 'Italy.', 'DBC']