['CONTRACTOR:', 'Battelle', 'Memorial', 'Institute', 'Pacific', 'Northwest', 'Laboratories', 'Richland,', 'Washington', '99352', 'EFFECTIVE', 'DATES:', 'Initiation:', 'June', '30,', '1974', 'Completion:', 'June', '29,', '1979', 'Funding:', 'June', '30,', '1974', '-', 'November', '30,', '1975', '$935,421', 'CONTRACT', 'NO.:', 'NOI-CP4-3315', 'CONTRACT', 'TITLE:', 'Inhalation', 'Bioassay', 'of', 'Cigarette', 'Smoke', 'in', 'Dogs:', 'High/Low', 'Nicotine', 'Content', 'OBJECTIVE:', 'Evaluation', 'of', 'carcinogenic', 'and', 'other', 'effects', 'from', 'cigarette', 'smoke,', 'especially', 'those', 'related', 'to', 'the', 'nicotine', 'content', 'of', 'the', 'smoke,', 'using', 'the', 'beagle', 'as', 'a', 'test', 'animal.', 'TASKS:', 'Phase', 'l', '1.', 'Set', 'up', 'facilities', 'for', 'routine', 'long-term', 'exposure', 'of', 'beagles,', 'via', 'tracheostoma,', 'to', 'cigarette', 'smoke', 'generated', 'by', 'machine.', '2.', 'Develop', 'technique', 'for', 'monitoring', 'inhaled', 'and', 'retained', 'dose,', '3.', 'Set', 'up', 'facilities', 'for', 'routine', 'chemical', 'analyses', 'to', 'monitor', 'smoke', 'composition.', '4,', 'Demonstrate', '1-3', 'to', 'the', 'Project', "Officer's", 'satisfaction', 'and', 'submit', 'full', 'experimental', 'procedures', 'for', 'the', 'following', 'work.', 'Phase', '2', '5.', 'On', 'approval,', 'set', 'up', 'and', 'conduct', 'exposure', 'of', '270', 'beagles', 'as', 'follows,', 'using', 'cigarettes', 'supplied', 'by', 'the', 'Government:', 'TIMN', '422199']