[' ', ' ', 'According', 'to', 'residuals', 'analysis', 'we', 'are', 'most', 'accurately', 'describing', 'the', 'effect', 'of', 'substitution', 'on', 'the', 'pyrrolidine', 'ring', 'and', 'at', 'the', '2', 'and', '4', 'positions', 'of', 'the', 'pyridine', 'moiety.', 'The', 'model', 'is', 'least', 'accurate', 'in', 'describing', 'the', 'effect', 'of', 'substitution', 'at', 'the', '5', 'and', '6', 'position', 'of', 'the', 'pyridine', 'moiety.', 'The', 'complexity', '(optimum', 'number', 'of', 'Components)', 'and', 'overall', 'accuracy', 'of', 'the', 'model', 'is', 'described', 'as', 'follows:', 'Standard', 'Error', 'of', 'Predictions', '(Cr', 'lida', 'Run#', 'Compl', 'Comp2', 'Comp3', 'Comp‘.', 'Comp5', 'aoorereos', '11', 'PKI', '0.853', '0.418', '0.420', '0.472', '0.594', 'R', 'squared', 'Run#', 'Compl', 'Comp2', 'Comp3', 'Comp4', 'Comp5', '-—-', '«', 'wooo', '=', 'mown', '11', 'PKI', '0.693', '0.930', '0.933', '0.921', '0.882', ' ', 'awasees', '£+', '+éjsasecce', 'F', 'values', '(nl=5,', 'n2=15', 'or', 'Run#', 'Compl', 'Comp2', 'Comp3', 'Comp4', 'Comp5', '“', 'W-—-', '©', 'eecescoee=', 'eel', 'ecomcesene', 'eceeeneese', 'ecennonecos', '’', '11', 'PKI', '6.777', '39.866', '41.948', '34.915', '22.522', 'Prob.of', 'R2=0', '(nl=', '5,', 'n2=15', ')', '-', 'Run#', 'Compl', 'Comp2', 'Comp3', 'Comp4', 'Comp5', ' ', ' ', ' ', ' ', 'eeeescomes', '11PKI', '0.002', '0.000', '0.000', '0.000', '0.000', 'Y', 'Scores.', '.', 'i', '#', 'Compl', 'Comp2', 'Comp3', '1', 'AMSNIC', '1.584', '0.130', '0.077', '2', 'MESNIC', '.', '1.984', '0.267', '0.079', '3', 'CS5NIC', '1.244', '0.150', '0.375', '4', 'FSNIC', '0.604', '0.250', '0.303', '$5', 'ME2NIC', '2.716', '1.339', '0.059', '6', 'ME6NIC', ',', '1.804', '0.095', '0.070', 'TNIC', '2.004', '0.343', '0.215', '8', 'NOR', '0.644', '0.658', '0.298', '9', 'FSNOR', '0.022', '0.022', '0.022', '10', 'ME2NOR', '-2.716', '1.506', '0.228', '11', 'AMINO4NOR', '-2.476', '1.188', '40.070', '12', 'AMINOSNOR', '0.034', '4.145', '0.417', '13', 'CLSNOR', '0.206', '0.397', 'A177', '14', 'ME6NOR', '1.004', '0.702', '0.192', '15', 'O3P-NICOTINE', '“1.716', '0.833', '0.167', '16', 'T3P-CY', 'ANOMENICOTINE', '0.716', '0.281', '0.135', ' ', ' ', 'ESL', 'Cé6RTS']