['06-23-93.', 'Page', '-67-', 'Acetaldehyde-mediated', 'cilia', 'dysfunction', 'in', 'bovine', 'bronchial', 'epithelial', 'cells', 'By', 'Sisson,', 'Joseph', 'H.;', 'Tuma,', 'Dean', 'J.;', 'Rennard,', 'Stephen', '1.', 'In', 'Eng', 'Am.', 'J.', 'Physiol.,', '260(2,', 'Pt.', '1),', 'L29-L36', '1991', '(CA', '114:158956y]', 'ABSTRACT>', 'The', 'authors', 'hypothesized', 'that', 'acetaldehyde', 'impairs', 'bronchial', 'epithelial', 'cilia', 'motion', 'by', 'inhibiting', 'cilia', 'dynein', 'ATPase', 'activity', 'through', 'the', 'formation', 'of', 'acetaldehyde', 'adducts', 'with', 'cilia', 'proteins.', 'Acetaldehyde', 'induced', 'concn.-', 'and', 'time-dependent', 'slowing', 'of', 'cilia', 'beating', 'and', 'cilia-derived', 'dynein', 'ATPase', 'activity', 'in', 'primary', 'cultures', 'and', 'isolated', 'axonemes', 'of', 'bovine', 'airway', 'epithelial', 'cells.', 'Cilia', 'slowing', 'and', 'ATPase', 'inhibitory', 'effects', 'were', 'also', 'obsd.', 'with', 'related', 'aldehydes', 'but', 'not', 'with', 'ethanol.', 'Acetaldehyde', 'binding,', 'assessed', 'by', 'gel', 'electrophoresis', 'using', '{14C]acetaldehyde,', 'was', 'demonstrated', 'to', 'occur', 'with', 'the', 'dynein', 'heavy', 'chains', 'and', 'with', 'tubulin', 'and', 'closely', 'paralleled', 'ATPase', 'inhibition.', 'Evidently,', 'acetaldehyde', 'directly', 'impairs', 'bronchial', 'cilia', 'function', 'causing', 'slowing', 'of', 'cilia', 'beating,', 'inhibits', 'cilia', 'dynein', 'ATPase', 'activity,', 'and', 'binds', 'to', 'cilia', 'proteins', 'crit.', 'for', 'motion', 'including', 'dynein', 'and', 'tubulin.', 'These', 'data', 'suggest', 'that', 'acetaldehyde-induced', 'cilia', 'dysfunction', 'may', 'be', 'related', 'to', 'direct', 'cilia', 'ATPase', 'inactivation', 'and', 'adduct', 'formation', 'with', 'cilia', 'dynein', 'and', 'tubulin.', 'This', 'may', 'be', 'an', 'important', 'mechanism', 'by', 'which', 'airway', 'host', 'defenses', 'are', 'impaired', 'in', 'clin.', 'settings', 'where', 'acetaldehyde', 'exposure', 'occurs,', 'e.g.,', 'with', 'cigaret', 'smoking', 'and', 'alc.', 'ingestion.', 'The', 'evaluation', 'of', 'genotoxicity', 'using', 'DNA', 'repairing', 'test', 'for', 'chemicals', 'produced', 'in', 'chlorination', 'and', 'ozonation', 'processes', 'By', 'Ono,', 'Yoshiro;', 'Somiya,', 'Isao;', 'Kawamura,', 'Masasumi', 'In', 'Eng', 'Water', 'Sci.', 'Technol.,', '23(1-3),', '329-38', '1991', '(CA', '114:158886a]', 'ABSTRACT>', 'The', 'umu-test', 'which', 'can', 'detect', 'the', 'induction', 'of', 'DNA', 'repair', 'is', 'applied', 'in', 'order', 'to', 'analyze', 'the', 'genotoxicity', 'of', 'byproducts', 'of', 'chlorination', 'and', 'ozonation.', 'In', 'this', 'research', 'work,', 'the', 'genotoxicities', 'of', '37', 'com.', 'chems.', 'which', 'are', 'expected', 'to', 'be', 'involved', 'in', 'the', 'byproducts', 'of', 'chlorination', 'and', 'ozonation', 'processes', 'are', 'checked', 'and', 'evaluated', 'by', 'the', 'umu-test.', 'The', 'effects', 'of', 'the', 'concn.', 'on', 'genotoxicities', 'of', 'those', 'chems.', 'are', 'discussed', 'and', 'compared', 'with', 'the', 'results', 'obtained', 'in', 'other', 'bacterial', 'assays.', 'Some', 'of', 'the', 'selected', 'org.', 'compds.', 'are', 'identified', 'pos.', 'genotoxic,', 'which', 'were', 'reported', 'not', 'to', 'be', 'mutagenic', 'in', 'other', 'bacterial', 'assays.', 'As', 'the', 'quant.', 'evaluation', 'for', 'genotoxicity', 'on', 'chem.', 'dose,', 'the', 'time', 'of', 'DNA', 'repairing', 'on', 'damaged', 'spots', 'by', 'SOS', 'genes', 'and', 'the', 'induction', 'rate', 'of', 'umu', 'gene', 'are', 'exptl.', 'evaluated.', "88'704924"]