['FIRST', 'DRAFT', 'mechanisms', 'by', 'which', 'cigarette', 'smoking', 'contributes', 'to', 'the', 'risk', 'factors', 'associated', 'with', 'atherosclerosis', 'and', 'chronic', 'obstructive', 'pulmonary', 'disease.', 'Collectively,', 'this.', 'work', 'clearly', 'demonstrates', 'the', 'feasibility', 'of', 'using', 'the', 'cigarette', 'smoking', 'baboon', 'as', 'a', 'model', 'for', 'the', 'study', 'of', 'the', 'health', 'effects', 'of', 'cigarette', 'smoking.', 'Although', 'our', 'efforts', 'to', 'date', 'have', 'primarily', 'involved', 'the', 'cardiovascular', 'and', 'pulmonary', 'systems,', 'the', 'model', 'could', 'readily', 'be', 'extended', 'to', 'include', 'other', 'body', 'systems.', 'The', 'instrumen-', 'tation', 'and', 'behavioral', 'and', 'dosimetry', 'techniques', 'needed', 'to', 'provide', 'an', 'integrated', 'test', 'system', 'have', 'been', 'developed', 'and', 'applied', 'in', 'large', 'experiments.', 'The', 'animals', 'do', 'smoke', 'in', 'a', 'fashion', 'similar', 'to', 'humans,', 'and', 'they', 'produce', 'carbon', 'monoxide,', 'thiocyanate,', 'cotinine,', 'and', 'particulate', 'deposition', 'doses', 'equivalent', 'to', 'those', 'seen', 'in', 'man', 'and', 'other', 'experimental', 'animal', 'models.', 'Independent', 'variables', 'can', 'be', 'manipulated,', 'and', 'important', 'variables', 'controlled,', 'so', 'that', 'statistically', 'significant', 'results', 'can', 'be', 'obtained', 'using', 'small', 'numbers', 'of', 'animals.', 'The', 'costs', 'of', 'research', 'with', 'the', 'system', 'are', 'known,', 'and', 'they', 'compare', 'favorably', 'with', 'those', 'associated', 'with', 'other', 'animal', '.', 'models.', ',', '.', 'The', 'ability', 'to', 'collect', 'integrated', 'data', 'on', 'a', 'set', 'of', 'physical,', 'chemical,', 'and', 'behavioral', 'variables', 'relevant', 'to', 'cigarette', 'smoking', 'allows', 'hypotheses', 'formulation', 'and', 'testing', 'to', 'proceed', 'at', 'a', 'level', 'of', 'sophistication', 'that', 'was', 'impossible', 'previously.', 'The', 'HLBI', 'studies', 'in', 'particular', 'provide', 'the', 'most', 'detailed', 'and', 'well-documented', 'study', 'yet', 'conductedi', 'on', 'the', 'acquisition', 'of', 'cigarette', 'smoking', 'in', 'a', 'model', 'functioning', 'similar', 'to', 'the', 'human', 'and', 'allow.', 'a', 'unique', 'opportunity', 'to', 'measure', 'sequential', 'changes', 'in', 'variables', 'related', 'to', 'risk', 'factors', 'that', 'should', 'provide', 'significant', 'new', 'information', 'concerning', '92', '-', '€260200009']