['Saal', 'Grant', '1011-AR1', 'Jay', 'A.', 'Levy,', 'M.D.', 'Cancer', 'Research', 'Institute', 'School', 'of', 'Medicine', '.', 's', 'University', 'of', 'California-', 'San', 'Francisco,', 'California', '94143', 'Possible', 'Genetic', 'Determinants', 'of', 'Chemical', 'Carcinogenesis.', 'The', 'objective', 'of', 'this', 'project', 'is', 'to', 'develop', 'a', 'model', 'system', 'in', 'vitro', 'for', 'studying', 'carcinomas.', 'Possible', 'interplay', 'of', 'endogenous', 'viruses', 'and', 'chemicals', 'in', 'cocarcinogenesis', 'will', 'be', 'investigated', 'here.', ' ', 'Continued', 'studies', 'on', 'the', 'genetic', 'basis', 'for', 'viral', 'and', 'chemical', 'carcinogenesis', 'will', 'be', 'conducted', 'by', 'breeding', 'experiments', 'using', 'NZB,', '129/J', 'and', 'SWR', 'mice.', 'NZB', 'mice', 'spontaneously', 'produce', 'significant', 'titers', 'of', 'xenotropic.', 'virus,', 'while', '129', 'and', 'SWR', 'produce', 'very', 'little.', 'The', 'possible', 'interplay', 'of', 'X-tropic', 'virus', 'production', 'and', 'chemical', 'induction', 'of', 'transformation', 'will', 'be', 'examined', 'by', 'using', 'Fy,', 'F2', 'and', 'several', 'back-cross', 'generations.', 'Current.', 'plans', 'include', 'derivation', 'of', 'congenic', 'strains', 'of', '129', 'mice', 'with', 'spontaneous', 'production', 'of', 'xenotropic', 'virus.', 'Further', 'studies', 'on', 'the', 'susceptibility', 'of', 'the', 'mice', 'to', 'chemically', 'induced', 'tumors', 'will', 'be', 'carried', 'out.', 'Activation', 'Date:', 'July', '1,', '1978', 'Current', 'Grant', 'Level:', '$69:,464).', 'A-39D', 'SSEPTPLO']