[' ', ' ', ' ', '_', 'EVALUATION', 'OF', 'AiR', 'CLEANER', 'EFFICIENCY', 'WITH', 'AN', 'APC!', 'MASS', 'SPECTROMETER', '.', 'R.J.', 'Reynolds', 'Tobacco', '-', 'Bowman', 'Gray', 'Technical', 'Center', 'Winston-Salem,', 'NC', '27102', 'USA', '.', 'obser', 'vers', 'authoritios', 'have', 'suggested', 'that', 'exposure', 'to', 'environmental', 'tobaoco', 'siinoke', '(ETS)', 'Jn', 'pocupational', 'environments', 'should', 'be', 'Iimited.', 'One', 'way', 'to', 'minimize', 'the', 'Impact', 'of', 'ETS', 'on', 'mdcor', 'alt', 'quslf', 'would', 'be', 'tne', 'use', 'of', 'effective', 'air', 'cleaners.', 'The', 'results', 'reported', 'here', 'are', 'a', 'subset', 'of', 'a', 'larger', 'expeliment', 'to', 'gauge', 'the', 'effectiveness', 'of', 'one', 'prototype', 'and', 'two', 'commercial', 'air', 'cleaners.', 'ETS', 'was', 'generated', 'in', 'an', '18-m*', 'controlled', 'environment', 'test', 'chamber.', 'A', 'SCIEX™', 'TAGA™', '6000', 'mass', 'spectrometer', 'was', 'used', 'to', 'monitor', 'the', 'air', 'concentrations', 'of', 'nicotine,', 'pyridine,', 'picoline,', 'ethyipyridine,', 'and', 'ethenytpyridine', 'in', 'real', 'time.', 'Experimental', 'data', 'were', 'analyzed', 'to', 'determine', 'whather', 'use', 'of', 'the', 'air', 'cleaners', 'resulted', 'in', 'significant', 'reductions', 'of', 'these', 'analytes', 'in', 'the', 'chamber', 'and', 'to', 'determine', 'the', 'effective', 'clean', 'alr', 'delivery', 'rate', '(CADR)', 'of', 'each', 'alr', 'cleaner.', ' ', 'The', 'chamber,', 'analyzers,', 'calibration,', 'and', 'data', 'analysis', 'have', 'been', 'described', "elsewhere'*.", 'Temperature', 'and', 'relative', 'humidity', 'were', 'controlled', 'at', '22°C', 'and', '50%.', 'The', 'chamber', 'was', 'ventilated', 'at', 'a', 'rate', 'of', '6', 'air', 'changes', 'per', 'hour.', 'Five', 'runs', 'were', 'performed', 'with', 'each', 'air', 'cleaner', 'and', 'ETS.', 'The', 'following', 'air', 'cleaners', 'were', 'evaluated:', 'OZNI-commercial', 'ozone/negative', 'ion', 'generator,', 'unit', 'was', 'adjusted', 'so', 'that', 'ozone', 'concentrations', 'in', 'the', 'chamber', 'did', 'not', 'exceed', '50', 'ppm', '(half', 'ozone’s', 'TLV);', 'ESP-Commercial', 'electrostatic', 'precipitator', 'with', 'minima!', 'charcoal', 'filtration;', 'COMB—prototype', 'unit', 'with', 'physical', 'filtration,', 'UV', 'ozone', 'generation,', 'and', 'charcoal', 'filtration.', 'Environmental', 'tobacco', 'smoke', 'was', 'initially', 'generated', 'by', 'sequentially', 'machine', 'smoking', 'two', 'pairs', 'of', 'University', 'of', 'Kentucky', '1R4F', 'reference', 'cigarettes.', 'Then,', 'individual', 'cigarettes', 'were', 'sequentially', 'machine', 'smoked', 'until', 'the', 'end', 'of', 'the', 'experiment.', 'The', 'smoking', 'was', 'preceded', 'by', 'a', 'twelve-minute', 'background', 'determination.', 'The', 'average', 'real-time', 'pyridine', 'concentration', 'in', 'the', 'chamber', 'during', 'each', 'test', 'is', 'depicted', 'in', 'Figure', '1.', 'Similar', 'response', 'was', 'observed', 'for', 'each', 'substituted', 'pyridine', 'measured,', 'Concentrations', 'appear', 'to', 'be', 'the', 'highest', 'with', 'the', 'OZNI', 'cleaner', 'on.', 'This', 'may', 'be', 'due', 'to', 'the', 'formation', 'of', 'nicotine', 'pyrolysis', 'products', 'in', 'the', 'ozone', 'generation', 'discharge.', 'Although', 'the', 'ESP', 'was', 'highly', 'efficient', 'at', 'removing', 'particles,', 'it', 'was', 'not', 'designed', 'for', 'the', 'effective', 'removal', 'of', 'vapor', 'phase', 'compounds.', 'The', 'COMB', 'air', 'cleaner', 'typically', 'temoved', '«50%', 'of', 'the', 'target', 'compounds.', 'This', 'was', 'probably', 'due', 'to', 'the', 'adsorption', 'of', 'gas', 'phase', 'components', 'onto', 'the', 'charcoal', 'bed.', 'Pyridine', '(ppb)', '  ', 'A', 'one-way', 'ANOVA', 'was', 'performed', 'on', 'results', 'for', 'each', 'analyte', 'by', 'alr', 'cleaner', 'type.', 'Following', 'x', 'ANOVA,', 'an', 'Bonferronl', 'adjusted', 'multiple', 'comparison', 'ree', '_(riie)', 'test', 'was', 'performed', '4%', 'determine', 'whether', 'Figure', '1.', 'Real-time', 'ETS', 'pyridine', 'concentration', 'in', 'the', 'differences', 'among', 'alr', 'cleaners', 'were', 'significant', 'at', 'chamber', 'with', 'and', 'without', 'each', 'type', 'Of', 'alr', 'cleaner', 'in', 'the', 'p<.05', 'level.', 'For', 'the', 'removal', 'of', 'piridine,', 'Operation.', ';', 'picoline,', 'and.', 'ethenyipyridine:', 'Neither', 'OZNI', 'nor', 'SFE', 'tos', 'wh', 'ee', 'ESP', 'significantly', 'reduced', 'chamber', 'Coricentrations;', 'concentrations', 'were', 'signiiicantly', 'higher', 'for', 'OZNI', 'compared', 'ty', 'to', 'ESP,', 'and', 'COMB', 'significantly', 'reduced', 'concentrations', 'of', 'these', 'compounds', 'In', 'the', 'chamber.', 'For', 'the', 'removal', 'of', 'Ethylpyridine:', 'no', 'significant', 'differences', 'were', 'observed', 'between', 'the', 'no', 'alr', 'cleaner,', 'OZNI,', 'or', 'ESP', 'conditions:', '“¢', 'COMB', 'significantly', 'reduced', 'concentrations', 'of', 'this', 'compound', 'relative', 'to', 'the', 'other', 'alr', 'cleaners', 'and', 'the', 'no', 'alr', '“4,', 'Cleaner', 'condition.', 'For', 'the', 'removal', 'of', 'nlootine:', 'thare', 'was', 'no', 'significant', 'difference', 'In', 'concentrations', 'OZNI', 'and', 'ho', 'alr', 'cleaner', 'conditions;', 'concentrations', 'were', 'not', 'significantly', 'different', 'with', 'the', 'OZNI,', 'ESP,', 'or', 'COMB', 'air', 'Cleaners', 'In', 'operation;', 'both', 'the', 'ESP', 'and', 'COMB', 'alr', 'cleaners', 'significantly', 'reduced', 'nlootine', 'concentrations', 'relative', 'to', 'the', 'no', 'alr', 'cleaner', 'condition.', ',', '“6', 'wa', ' ', 'ai', '9S', 'Oo', 'on', '“I', 'o)', 'a', 'B', '~', ' ']