['10.', 'AUERBACH,', 'Oscar,', 'MD,', 'HAMMOND,', 'E.', 'Cuyler,', 'ScD,', 'KIRMAN,', 'David,', 'and', 'GARFINKEL,', 'Lawrence,', 'MA,', 'Veterans', 'Administration,', 'East.', 'Orange,', 'N.J.,', 'and', 'American', 'Cancer', 'Society,', 'New', 'York', 'City', '"Emphysema', 'produced', 'in', 'dogs', 'by', 'cigarette', 'smoking."', '(Journal', 'of', 'the', 'American', 'Medical', 'Association', '199/4:241-246,', 'January', '23,', '1967)', 'The', 'data', 'and', 'wording', 'are', 'virtually', 'identical', 'with', 'the', 'paper', 'presented', 'at', 'the', 'AMA', 'annual', 'convention', 'in', 'Chicago', 'on', 'June', '27,', '1966', '(Current', 'Digest,', 'July', '1966,', 'page', '7),', 'except', 'for', 'a', 'section', 'subtitled', '"Comment,"', 'excerpts', 'from', 'which', 'follow:', '"Hematocrit', 'studies', 'were', 'made', 'on', 'the', 'dogs', 'because', 'in', 'a', 'previous', 'experiment', 'on', 'human', 'beings,', 'cigarette', 'smoking,', 'was', 'found', 'to', 'be', 'associated', 'with', 'a', 'marked', 'increase', 'in', 'hematocrit,', 'and', 'the', 'authors', 'suggested', 'that', 'this', 'might.', 'possibly', 'be', 'related', 'to', '‘the', 'occurrence', 'of', 'diseases', 'characterized', 'by', 'thrombus', 'formation', '/Eisen', '&', 'Hammond,', 'Can.', 'Med.', 'A.', 'J.', '75:520,', '1956', '7.!', 'Hematocrit', 'values.', 'of', 'the', 'dogs', 'increased', 'with', 'smoking', '(though', 'later', 'they', 'declined', 'somewhat),', 'and', 'several', 'of', 'the', 'dogs', 'died', 'of', 'thrombosis.', 'with', 'pulmonary', 'emboli', 'and', 'infarction.', 'Whether', 'these', 'two', 'events.', 'were', 'causally', 'related', 'is', 'a', 'matter', 'of', 'conjecture....', '"Heart', 'weight', 'per', 'kilogram', 'of', 'body', 'weight', 'was', 'found', 'to', 'pe', 'greater', 'in', 'the', 'smoking', 'dogs', 'than', 'in', 'the', 'control', 'dogs.', 'Perhaps', 'this', 'was', 'secondary', 'to', 'lung', 'parenchymal', 'changes,', 'as', 'in', 'cor', 'pulmonale,', 'but', 'this', 'is', 'not', 'necessarily', 'the', 'correct', 'interpretation."', 'BOUCHARD,', 'J.', 'and', 'MAY,', 'R.', 'M.,', 'Laboratory', 'of', 'Comparative', 'Anatomy,', 'Faculty', 'of', 'Seiences', "d'Orsay,", 'University', 'of', 'Paris,', 'France', '"Effets', 'des', 'goudrons.', 'de', 'tabac', 'sur', "l'embryon", 'de', 'poulet', 'traité', 'au', 'cinquieme', 'jour."', '(Comptes', 'Rendus', 'de', "1'Association", 'des', 'Anatomistes', '134:185-198,', 'September', '1966:', "Authors'", 'English', 'summary)', '1.', 'Five', "days'", 'old', 'chick', 'embryos', 'were', 'treated', 'with', 'tobacco', 'tars', 'dissolved', 'in', 'carbowax,', 'and', 'by', 'pure', 'carbowax.', '2,', 'Histological', 'studies', 'on', 'the', '10th', 'day', 'of', 'development', 'show', 'that', 'the', 'tars', 'bring', 'about', 'an', 'important', 'mortality,', 'frequent', 'coelosomies', 'and', 'numerous', 'hemorrhages,', 'while', 'pure', 'carbowax', 'has', '4', 'similar', 'action,', 'but', 'much', 'less:', 'marked.', '3.', 'Besides,', 'with', 'tobacco:', 'tars', 'abnormal', 'mitoses', 'are', 'very', 'numerous', 'and', 'accompanied', 'by', 'dystrophy', 'of', 'mesenchymatous', 'elements;', 'we', 'observed', 'lesions', 'of', 'mitotic', 'spindles', 'four', 'times', 'more', 'often', 'than', 'in', 'the', 'case', 'of', 'embryos', 'treated', 'by', 'pure', 'carbowax.', '269890ST02']