[' ', 'adjutant', 'effect', 'on', 'the', 'primary', 'sensitisation', 'against', 'ovalbumin', 'with', '0.001%', 'and', '6.0001%', 'LAS,', 'respectively.', 'PP1-3', 'ANTIOXIDAT1VE', 'POTENTIAL', 'IN', 'CADMIUM', 'PROVOKED', 'OXIDATIVE', 'STRESS', 'IN', 'RATS', 'The', 'Nofer', 'Institute', 'of', 'Occupational', 'Medicine,', 'Lodz,', 'Poland', 'Justyna', 'M', 'Wisniewska-Knyp!*', 'and', 'Teresa', 'Wronska-Nofer', 'Antioxidative,', 'compensating', 'mechanisms', 'in', 'response', 'to', 'cadmium-provoked', 'oxidative', 'stress', 'were', 'studied', 'in', 'rats', 'given', 'CdCl,', 'at', 'doses', '1', 'mg', 'Cd/kg', 'twice', 'weekly', 'for', '10', 'weeks.', 'It', 'has', 'been', 'found', 'a', 'distinct', 'character', 'of', 'antioxidative', 'efficiency', 'in', 'the', 'liver', 'and', 'kidneys', 'supposed', 'to', 'be', 'crucial', 'for', 'restraining', 'the', 'extent', 'of', 'prooxidative/toxic', 'effects', 'produced', 'by', 'cadmium', 'in', 'that', 'target', 'organs:', '[1]', 'liver', '-', 'predominant', '{by', '570%)', 'induction', 'of', 'heme', 'oxygenase', 'with', 'minor', 'stimulation', 'of', 'glutathione-S-transferase', '(by', '50%)', 'vs', 'enhanced', 'lipid', 'peroxidation', '(by', '140%)', 'resulted', 'in', 'a', 'marked', 'oxidative', 'stress;', '[2]', 'kidneys', '-', 'induction', 'of', 'heme', 'oxygenase', '(by', '200%)', 'with', 'stimulation', 'of', 'glutathione-S-transferase', '(by', '80%),', 'selenium-independent', 'glutathione', 'peroxidase', '(by', '100%)', 'and', 'increase', 'of', 'glutathione', 'level', '(by', '160%)', 'vs', 'enha-', 'nced', 'lipid', 'peroxidation', '(by', '40%)', 'resulted', 'in', 'a', 'minor', 'oxidative', 'stress.', 'Compensating', 'antioxidative', 'mechanism', 'in', 'kidneys', 'may', 'be', 'decisive', 'for', 'the', 'delayed', 'nephrotoxicity', 'of', 'cadmium.', 'PP1-4', 'COMPARISION', 'OF', 'BLOOD', 'AND', 'SPLEEN', 'LYMPHOCYTES', 'AS', 'TARGETS', 'FOR', 'IMMUNOTOXIG', 'EFFECTS', 'IN', 'THE', 'RAT:', 'PRELIMINARY', 'STUDIES', 'WITH', 'CYCLOPHOSPHAMIDE', 'Department', 'of', 'Environmental', 'Medicine,', 'National', 'Institute', 'of', 'Public', 'Health,', 'Oslo,', 'Norway', 'Unni', 'Cecilie', 'Nvgaard', 'and', 'Martinus', 'Lovik*', ' ', 'The', 'rat', 'has', 'a', 'blood', 'volume', 'large', 'enough', 'for', 'the', 'preparation', 'of', 'lymphocytes', 'for', 'immunological', 'testing.', 'Results', 'with', 'rat', 'blood', 'lymphocytes', 'might', 'be', 'more', 'comparable', 'to', 'results', 'obtained', 'with', 'human', 'peripheral', 'blood', 'cells', 'than', 'results', 'obtained', 'with', 'the', 'commonly', 'used', 'rat', 'spleen', 'cells.', 'Sensitivity', 'to', 'immunotoxic', 'effects', 'might', 'differ', 'between', 'spleen', 'and', 'blood', 'lymphocytes.', 'In', 'preliminary', 'experiments,', 'we', 'compared', 'the', 'effect', 'from', 'a', 'single', 'dose', 'of', '18', 'mg/kg', 'or', '35', 'mg/kg', 'cyclophosphamide', '(CY)', 'given', 'intraperitoneally', '24', 'h', 'or', '48', 'h', 'before', 'testing.', 'Immunophenotyping', 'by', 'flow', 'cytometry', 'and', 'determination', 'of', 'the', 'proliferative', 'response', 'to', 'mitogen', 'stimulation', 'were', 'performed', 'fo', 'detect', 'immune', 'system', 'changes', 'in', 'response', 'to', 'CY.', 'Lymphocytes', 'from', 'blood', 'and', 'the', 'spleen', 'were', 'found', 'to', 'differ', 'in', 'their', 'sensitivity', 'to', 'the', 'immunotoxicant.', 'What', 'source', 'of', 'lymphocytes', 'best', 'allowed', 'the', 'detection', 'of', 'immunotoxic', 'effects', 'from', 'nN', '(5)', 'o', 'NS', '=', 'ph', '9', 'a]', 'So', '°', ' ']