['CONTRACTOR:', 'New', 'York', 'University', 'Medical', 'Center', 'Institute', 'of', 'Environmental', 'Medicine', '550', 'First', 'Avenue', 'New', 'York,', 'New', 'York', '10016', 'EY', 'fECTIVE', 'DATES:', 'Initiation:', 'January', '1,', '1974', 'CONTRACT', 'NO.:', 'Completion:', 'January', '31,', '1975', 'Funding:', '$145,000', 'NO1-CP3-', '3241', 'CONTRACT', 'TITLE:', 'Studies', 'on', 'Carcinogenic', 'Principles', 'of', 'OBJECTIVE:', 'TASKS:', 'RATIONALE:', 'COLLABORATING', 'ORGANIZATIONS:', 'Processed', 'Tobacco', 'and', 'Tobacco', 'Smoke', 'To', 'study', 'the', 'various', 'promoters,', 'cocarcinogens,', 'anticarcinogens', 'and', 'carcinogens', 'in', 'cigarette', 'smoke', 'condensate', 'using', 'various', 'methods', 'of', 'fractionation', 'and', 'bioassay.', '1.', 'Search', 'for', 'pyrogallol', 'in', 'cigarette', 'smoke', 'condensate', '(CSC).', '2.', 'Perform', 'hydrocarbon', 'hydroxylase', 'assays', 'on', 'various', 'aromatic', 'hydrocarbons', 'and', 'phenolic', 'cocarcinogens,', '3.', 'Perform', 'two-stage', 'carcinogen', 'and', 'cocarcinogen', 'assays', 'on', 'compounds', 'such', 'as', 'cresols,', 'guaiacol,', 'caffeic', 'acid,', 'quinic', 'acid,', '4-allylcatechol,', '3-', 'and', '4-methoxyphenol,', 'xylenols,', 'and', 'Cop,', 'and', 'higher', 'saturated', 'hydrocarbons.', '4.', 'Explore', 'the', 'possibility', 'of', 'developing', 'a', 'cell', 'culture', 'assay', 'for', 'cocarcinogenesis.', 'This', 'project', 'represents', 'an', 'attempt', 'to', 'isolate', 'and', 'characterize', 'chemical', 'compounds', 'which', 'may', 'act', 'as', 'promoters', 'or', 'cocarcinogens', 'in', 'cigarette', 'smoke.', 'Such', 'knowledge', 'is', 'indispensable', 'in', 'developing', 'a', 'less', 'hazardous', 'cigarette.', 'None.', 'TIMN', '422220']