['Testimony', 'of', 'John', 'A.', 'Moore,', 'Subcommittee', 'Inv.', '&', 'Oversight,', '7/27/93', ':', '7', 'BROADEN', 'THE', 'BASE', 'OF', 'PARTICIPATION', 'The', 'composition', 'and', 'technical', 'details', 'that', 'constitute', 'a', 'risk', 'assessment', 'process', 'are', 'known', 'and', 'understood', 'by', 'a', 'relatively', 'small', 'number', 'of', 'individuals.', 'The', 'best', 'known', 'process', 'is', 'that', 'which', 'was', 'articulated', 'by', 'EPA', 'in', 'its', 'Cancer', 'Guidelines', 'developed', 'in', 'the', 'mid', '1980s.', 'Other', '_', 'guidelines', 'exist', 'that', 'address', 'such', 'topics', 'as', 'developmental', 'toxicity', 'and', 'exposure.', 'Several', 'aspects', 'significantly', 'limit', 'the', 'effectiveness', 'and', 'utility', 'of', 'Guidelines.', 'These', 'include:', '1)', 'failure', 'to', 'develop', 'guidelines', 'for', 'such', 'key', 'areas', 'as', 'general', '(systemic)', 'toxicity,', 'neurotoxicity', 'or', 'immune', 'effects;', '2)', 'failure', 'to', 'revise', 'guidelines', 'or', 'adapt', 'practices', 'to', 'reflect', 'advances', 'in', 'scientific', 'knowledge', 'in', 'a', 'timely', 'manner;', 'and', '3)', 'limits', 'of', 'guidelines', 'to', 'the', 'practices', 'of', 'a', 'single', 'agency.', 'There', 'is', 'an', 'overdue', 'need', 'for', 'this', 'government', 'to', 'establish', 'a', 'uniform', 'approach', 'to', 'risk', 'assessment', 'that', 'reflects', 'the', 'best', 'application', 'of', 'scientific', 'knowledge', 'and', 'therefore', 'has', 'a', 'broad', 'base', 'of', 'support.', 'To', 'attain', 'this', 'end', 'there', 'must', 'be', 'a', 'mechanism', 'to', 'involve', 'a', 'broad', 'base', 'of', 'people', 'with', 'appropriate', 'experience', 'and', 'scientific', 'knowledge.', 'Such', 'action', 'would', 'be', 'a', 'significant', 'departure', 'from', 'the', 'typical', 'practice', 'where', 'the', 'process', 'is', 'controlled', 'and', 'dominated', 'by', 'the', 'federal', 'regulatory', 'agencies.', 'There', 'is', 'a', 'successful', 'precedent', 'being', 'established', 'that', 'uses', 'such', 'a', 'mechanism.', 'The', 'Institute', 'for', 'Evaluating', 'Health', 'Risks', 'is', 'completing', 'the', 'development', 'and', 'testing', 'of', 'an', 'evaluative', 'process', 'for', 'assessing', 'the', 'potential', 'of', 'agents', 'to', 'cause', 'human', 'reproductive', 'or', 'developmental', 'toxicity.’', 'This', 'project’', 'has', 'received', 'equal', 'funding', 'from', 'the', 'federal', 'government', 'and', 'the', 'private', 'sector,', 'The', 'broad', 'base', 'of', 'participation,', 'drawn', 'from', 'universities,', 'state', 'health', 'and', 'environmental', 'departments,', 'commercial', 'companies', 'and', 'federal', 'research', 'and', 'regulatory', 'agencies', 'capitalized', 'on', 'diverse', 'experience.', 'This', 'mechanism', 'enhances', 'broad', 'awareness', 'and', 'acceptance', 'that', 'the', 'process', 'represents', 'application', 'of', 'state-of-the-art', 'knowledge.', 'I', 'believe', 'that', 'is', 'fundamental', 'to', 'earning', 'public', 'trust.', 'SCIENCE', 'PEER', 'REVIEW', 'A', 'final', 'topic', 'I', 'wish', 'to', 'discuss', 'is', 'the', 'process', 'of', 'scientific', 'peer', 'review.', 'As', 'previously', 'discussed,', 'the', 'development', 'of', 'guidelines', 'certainly', 'needs', 'peer', 'participation', 'and', 'review.', '7', 'The', 'project', 'has', 'developed', 'a', 'document', 'entitled', '4m', 'Evaluative', 'Process', 'for', 'Evaluating', 'the', 'Potential', 'of', 'Agents', 'to', 'Cause', 'Human', 'Reproductive', 'or', 'Developmental', 'Toxicity.', 'To', 'demonstrate', 'the', 'utility', 'of', 'the', 'process,', 'including', 'communicating', 'the', 'expert', 'judgments', 'in', 'terms', 'that', 'are', 'understood', 'by', 'risk', 'managers,', 'several', 'chemical', 'evaluations', 'were', 'conducted,', 'i.e.,', 'lithium,', 'ethylene', 'glycol,', 'boric', 'acid', 'and', 'several', 'phthalates.', 'The', 'final', 'report', 'and', 'chemical', 'evaluations', 'should', 'be', 'available', 'for', 'distribution', 'in', 'the', 'fall,', '1993.', 'O2082SS202']