['CONTRACTOR:', 'Veterans', 'Administration', 'Hospital', 'East', 'Orange,', 'New', 'Jersey', '07019', 'EFFECTIVE', 'DATES:', 'Initiation:', 'July', '1,', '1974', 'CONTRACT', 'NO.:', 'Completion:', 'June', '30,', '1975', 'Budget:', '$277,437', 'YO1-CP4-0205', 'CONTRACT', 'TITLE:', 'Test', 'Effects', 'of', 'High', 'Low', 'Nicotine', 'Cigarettes', 'OBJECTIVE:', 'TASKS:', 'on', 'Male', 'Beagle', 'Dogs', 'Elucidate', 'the', 'role', 'of', 'nicotine', 'in', 'disease', 'related', 'tobacco', 'smoking.', 'Determining', 'whether', 'nicotine', 'is', 'importantly', 'involved', 'in', 'the', 'harmful', 'effects', 'produced', 'on', 'male', 'beagle', 'dogs', 'by', 'daily', 'inhalation', 'of', 'cigarette', 'smoke.', 'Experimental', 'Design', '45', 'dogs', 'exposed', 'daily', 'to', 'smoke', 'of', 'low', 'nicotine', 'content.', '55', 'dogs', 'exposed', 'daily', 'to', 'smoke', 'of', 'high', 'nicotine', 'content.', '15', 'dogs', 'for', 'control,', 'sham-smoked.', 'Critical', 'events', 'and', 'dates:', 'Weekly', '-', 'weight,', 'temperature', 'and', 'physical', 'examination.', 'Day', '150', '-', 'begin', 'EKG;', 'blood', 'chemistry;', 'and', 'opthalmoscopic,', 'broncho-', 'scopic', 'and', 'roentgenographic', 'tests.', 'Repeat', 'quarterly.', 'TIMN', '422223']