['aa', 'Inveresk', 'Research', 'International', '15', '2.', 'Subchronic', 'Toxicity', '(up', 'to', '3', 'months)', 'Dose', 'limits', 'have', 'been', 'set', 'such', 'that', 'a', 'pesticide', 'cannot', 'be', 'registered', 'if', 'it', 'contains', 'more', 'than', '5%', 'of', 'an', 'active', 'ingredient', 'which', 'causes', '‘serious', "damage'", 'to', 'health', 'at', 'levels', 'below', 'the', 'dose', 'limits.', 'Examples', 'given', 'of', '‘serious', 'damage’', 'are:', 'Significantly', 'increased', 'mortality.', '-', 'Preneoplastic', 'changes.', '~', 'Impairment', 'of', 'visual', 'power', 'or', 'structural', 'changes', 'of', 'the', 'eye.', 'Impairment', 'of', 'sense', 'of', 'hearing', 'or', 'structural', 'changes', 'of', 'the', 'middle', 'ear', 'and', 'the', 'internal', 'ear.', '-', 'Irreversible', 'damage', 'to', 'the', 'central', 'nervous', 'system', 'and/or', 'peripheral', 'system', 'manifested', 'as', 'behavioural', 'and/or', 'functional', 'disturbances,', 'and', 'as', 'structural', 'or', 'biochemical', 'changes.', '~', 'Irreversible', 'damage', 'to', 'vital', 'organs:', 'heart,', 'liver,', 'kidneys,', 'bone', 'marrow,', 'lungs,', 'endocrine', 'glands.', 'Irreversible', 'damage', 'is', 'defined', 'as', 'changes', 'in', 'animal', 'studies', 'which', 'do', 'not', 'recover', 'after', 'a', 'period', 'of', 'a', 'few', 'months.', 'The', 'dose', 'limits', 'are:', '5', 'mg.kg*', 'body', 'weight.day*', 'for', 'the', 'oral', 'route,', '10', 'mg-kg™', 'body', 'weight.day?', 'for', 'the', 'dermal', 'route,', 'and', '0.05', 'mg.', 'Titre",', '6', 'h.day*', 'for', 'the', 'inhalation', 'route', 'of', 'administration.', '3.', 'Chronic', 'Toxicity', '(at', 'least', '12', 'months)', '_', 'An', 'oral', 'dose', 'limit', 'of', '0.5', 'mg.kg*', 'body', 'weight.day*', 'has', 'been', 'set', 'and', 'a', 'pesticide', 'cannot', 'be', 'registered', 'if', 'it', 'contains', 'more', 'than', '5%', 'of', 'an', 'active', 'ingredient', 'causing', 'functional', 'disturbance', 'or', 'structural', 'changes', 'of', 'biological', 'significance', 'at', 'levels', 'below', 'this', 'dose', 'limit.', 'Examples', 'given', 'of', 'such', 'effects', 'in', 'these', 'tests', 'are:', '-', 'Significantly', 'increased', 'Mortality.', '-', 'Structural', 'changes', 'of', 'the', 'eye.', '-', 'Irreversible', 'damage', 'to', 'vital', 'organs:', 'heart,', 'liver,', 'kidneys,', 'bone', 'marrow,', 'lungs,', 'endocrine', 'glands.', 'Atherosclerosis', 'and', 'other', 'chronic', 'vascular', 'changes.', ' ', '9P26', 'B6Lo5', 'F', 'I', 'i', 'i', ' ', ' ']