MAR DEL PLATA, Argentina (Reuters) - The Argentine navy raised the possibility on Thursday that a navy submarine missing in the South Atlantic suffered an explosion, heightening concerns over the fate of the 44 crew members on the eighth day of an international search effort. A sound detected underwater by an international agency on the morning of Nov. 15, around the time the ARA San Juan sent its last signal and in the same area, was  consistent with an explosion,  navy spokesman Enrique Balbi told reporters. The sub had only a seven-day supply of oxygen, a fact that drained hope from some of the relatives of the crew who have gathered at the vessel s base in the city of Mar del Plata.  What s the point of hope if it s already over?  Itati Leguizamon, wife of one of the missing crew members, told reporters.  The navy did not have enough information to say what the cause of the explosion could have been or whether the vessel might have been attacked, Balbi said. Search-and-rescue crews were undeterred by a series of false leads that raised hope over recent days that the sub might be located. Asked during an evening news conference about the fate of the 44 sailors, Balbi said the situation was  critical .  We are not going to enter into conjecture out of respect for the families,  he added. The information about the possible explosion was received  on Thursday from the Comprehensive Nuclear Test-Ban Treaty Organization, or CTBTO, an international body that runs a global network of listening posts designed to check for secret atomic blasts. The Vienna-based agency, which has monitoring stations equipped with devices including underwater microphones that scan the oceans for sound waves, said in a statement that two of its  stations had detected an unusual signal near where the submarine went missing. The agency was more guarded about whether that  was caused by an explosion. A huge sea and air hunt is being conducted for the San Juan, a German-built, diesel-electric powered submarine that was launched in 1983, as crew members  relatives waited anxiously for news more than a week after the vessel disappeared. The relatives had been largely optimistic until Thursday. They shed tears and insulted authorities after being briefed on the news of the possible explosion. They were told about it before the public announcement. Balbi said the news of the abnormal sound was consistent with a separate report received on Wednesday of an  acoustic anomaly  in the same area and around the same time. The San Juan was some 430 km (270 miles) off the Patagonian coast when it sent its last signal.  This is very important because it allows us to correlate and confirm the acoustic anomaly from the U.S. report yesterday,  Balbi said.  Here, we re talking about a singular, short, violent, non-nuclear event, consistent with an explosion.  In Vienna, CTBTO hydroacoustic engineer Mario Zampolli said the signal his agency had detected  could be consistent with an explosion but there is no certainty about this.  Speaking to Reuters, he agreed with Balbi s description of the signal as unusual and short, adding that the cause was non-natural. The submarine was en route from Ushuaia, the southernmost city in the world, to Mar del Plata, 400 km (250 miles) south of Buenos Aires, when it reported an electrical malfunction shortly before disappearing. Some relatives have questioned authorities for letting the crew navigate on an ageing submarine - criticism that has highlighted the armed forces  dwindling resources since the end of a military dictatorship in the 1980s.  Authorities have said the level of maintenance, not the age, was what mattered, and that the vessel was in good condition.  