Thermal Decomposition of Some Cardiovascular Drugs (Telmisartane, Cilazapril and Terazosin HCL)

Abstract

Thermal analysis of some antihypertensive drugs, Telmisartan, Cilazapril and Terazosin HCL was achieved. Thermogravimetry, derivative thermogravimetry and differential thermal analysis were used through the work. Thermogravimetric parameters such as activation energy, frequency factor and reaction order were calculated. The results show the stability value decrease in the order Telmisartan > Cilazapril > Terazosin. This method can be used in the quality control of pharmaceutical compounds because it is simple, fast and cheap.

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L. Al-Harbi, E. El-Mossalamy, A. Obaid and M. EL-RIES, "Thermal Decomposition of Some Cardiovascular Drugs (Telmisartane, Cilazapril and Terazosin HCL)," American Journal of Analytical Chemistry, Vol. 4 No. 7, 2013, pp. 337-342. doi: 10.4236/ajac.2013.47042.

Conflicts of Interest

The authors declare no conflicts of interest.

References

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H. Horowitz and G. Metzger, \u201cA New Analysis of Thermogravimetric Traces,\u201d Analytical Chemistry, Vol. 35, No. 10, 1963, pp. 1464-1468. doi:10.1021/ac60203a013\n[13] A. W. Coats and J. P. Redfern, \u201cKinetic Parameters from Thermogravimetric Data,\u201d Nature, Vol. 201, 1964, pp. 68-69.\n\nCopyright \u00a9 2024 by authors and Scientific Research Publishing Inc.\n\nThis work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.", "rmaceutical Composition,\u201d 1992.\n[12] H. H. Horowitz and G. Metzger, \u201cA New Analysis of Thermogravimetric Traces,\u201d Analytical Chemistry, Vol. 35, No. 10, 1963, pp. 1464-1468. doi:10.1021/ac60203a013\n[13] A. W. Coats and J. P. Redfern, \u201cKinetic Parameters from Thermogravimetric Data,\u201d Nature, Vol. 201, 1964, pp. 68-69.\n\nCopyright \u00a9 2024 by authors and Scientific Research Publishing Inc.\n\nThis work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.", "rmaceutical Composition,\u201d 1992.\n[12] H. H. Horowitz and G. Metzger, \u201cA New Analysis of Thermogravimetric Traces,\u201d Analytical Chemistry, Vol. 35, No. 10, 1963, pp. 1464-1468. doi:10.1021/ac60203a013\n[13] A. W. Coats and J. P. Redfern, \u201cKinetic Parameters from Thermogravimetric Data,\u201d Nature, Vol. 201, 1964, pp. 68-69.\n\nCopyright \u00a9 2024 by authors and Scientific Research Publishing Inc.\n\nThis work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License."]}