Norfenfluramine

Norfenfluramine
Names
IUPAC name
1-[3-(Trifluoromethyl)phenyl]propan-2-amine
Other names
3-Trifluoromethylamphetamine
Identifiers
19036-73-8 Y
3D model (Jmol) Interactive image
ChemSpider 15108 Y
ECHA InfoCard 100.038.866
215
PubChem 15897
Properties
C10H12F3N
Molar mass 203.21 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Norfenfluramine, or 3-trifluoromethylamphetamine, is a never-marketed drug of the amphetamine family which behaves as a serotonin and norepinephrine releasing agent and potent 5-HT2A, 5-HT2B, and 5-HT2C agonist. The action of norfenfluramine on 5-HT2B receptors on heart valves leads to a characteristic pattern of heart failure following proliferation of cardiac fibroblasts on the tricuspid valve, known as cardiac fibrosis.[1] This side effect led to the withdrawal of fenfluramine as an anorectic agent worldwide, and to the withdrawal of benfluorex in Europe,[2] as both fenfluramine and benfluorex form norfenfluramine as an active metabolite. It is a human TAAR1 agonist.[3]

See also

References


This article is issued from Wikipedia - version of the 6/4/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.
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