Effect of Piperine in Obesity Induced Insulin Resistance and Type_II Diabetes Mellitus in Rats


Affiliations

  • K. B. Raval College of Pharmacology, Department of Pharmacology, Gandhinagar, Gujarat, 382023, India
  • K. B. Institute of Pharmaceutical Education and Research, Department of Pharmacology, Gandhinagar, Gujarat, 382023, India
  • Crimea State Medical University, Simferopol, Ukraine

Abstract

Objective: The present study was undertaken to explore the effect of piperine in obesity induced insulin resistance and type 2 diabetes mellitus. Materials and methods: Male Sprague dawley rats were fed High fat diet (HFD) for first 8 weeks to develop obesity which induced insulin resistance and diabetes mellitus. Later on piperine (400 mg/kg) and sibutramine (5 mg/kg) were administered for 3 weeks along with the continuation of HFD to two separate groups which served as test and standard respectively. Result: Body weight, serum triglyceride and glucose levels were measured at the end of 4th, 8th (before treatment) and 11th (after treatment) week while insulin tolerance test and fat mass were measured at the end of 11th week in normal, HFD-control, test and standard groups. Conclusion: Piperine significantly reduced not only body weight, fat mass, triglyceride and glucose levels but also improved sensitivity of exogenous insulin. The above results suggest that piperine has significant anti-obesity, antidiabetic activity and also improved insulin sensitivity.

Keywords

Obesity, Diabetes, Insulin, Piperine, High-Fat Diet, Sibutramine.

Subject Discipline

Pharmacy and Pharmacology

Full Text:

Refbacks

  • There are currently no refbacks.
{"cc_re__cc_re__cc_by_4_0": [".\"/>\n\t<meta name=\"DC.Format\" scheme=\"IMT\" content=\"application/pdf\"/>\n\t<meta name=\"DC.Identifier\" content=\"252\"/>\n\t<meta name=\"DC.Identifier.pageNumber\" content=\"116-122\"/>\n\t\t\t\t\t\t\t<meta name=\"DC.Identifier.DOI\" content=\"10.18311/jnr/2010/252\"/>\n\t\t<meta name=\"DC.Identifier.URI\" content=\"http://www.informaticsjournals.com/index.php/jnr/article/view/252\"/>\n\t<meta name=\"DC.Language\" scheme=\"ISO639-1\" content=\"en\"/>\n\t<meta name=\"DC.Rights\" content=\"Copyright (c) 2010 Journal of Natural Remedies\" />\n\t<meta name=\"DC.Rights\" content=\"http://creativecommons.org/licenses/by/4.0\"/>\n\t<meta name=\"DC.Source\" content=\"Journal of Natural Remedies\"/>\n\t<meta name=\"DC.Source.ISSN\" content=\"2320-3358\"/>\n\t<meta name=\"DC.Source.Issue\" content=\"2\"/>\t<meta name=\"DC.Source.URI\" content=\"http://www.informaticsjournals.com/index.php/jnr\"/>\n\t<meta name=\"DC.Source.Volume\" content=\"10\"/>\t\t\t\t\t\t<meta name=\"DC.Subject\" xml:lang=\"en\" content=\"Obesity, Diabetes, Insulin, Piperine, High-Fat Diet, Sibutramine.\"/>\n\t\t\t\t<meta name=\"DC.Title\" content=\"Effect of Piperine in Obesity Induced Insulin Resi", "g\" alt=\"Open Access\" />\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t</div>\n\t\n\t\n<!--\t\t\t\t\t\t\t<br />\n\t\t<br />\n\t\tDOI: <a id=\"pub-id::doi\" href=\"https://doi.org/10.18311/jnr/2010/252\">https://doi.org/10.18311/jnr/2010/252</a>\t-->\n\n\n<div class=\"separator\"></div>\n\n<h3>Refbacks</h3>\n\n<ul>\n\t\t\t\t<li>There are currently no refbacks.</li>\n\t</ul>\n       <!--                 <br/><br/>\n                Copyright (c) 2010 Journal of Natural Remedies\n        -->\n        <div class=\"creativeClogo\">\n\t                <br /><br />\n                <a rel=\"license\" href=\"http://creativecommons.org/licenses/by/4.0/\"><img alt=\"Creative Commons License\" style=\"border-width:0\" src=\"http://i.creativecommons.org/l/by/4.0/88x31.png\" /></a><br />This work is licensed under a <a rel=\"license\" href=\"http://creativecommons.org/licenses/by/4.0/\">Creative Commons Attribution 4.0 International License</a>.\n        \t</div>\n\n</div><!-- content -->\n</div><!-- main -->\n</div><!-- body -->\n\n<!--\t\t\t<br/><br/>\n\t\tCopyright (c) 2010 Journal of Natural Remedies\n\t\t\t\t<br /><br />\n\t\t<a rel=\"license\" href=\"http://creativecommons.org/", "v>\n\n<h3>Refbacks</h3>\n\n<ul>\n\t\t\t\t<li>There are currently no refbacks.</li>\n\t</ul>\n       <!--                 <br/><br/>\n                Copyright (c) 2010 Journal of Natural Remedies\n        -->\n        <div class=\"creativeClogo\">\n\t                <br /><br />\n                <a rel=\"license\" href=\"http://creativecommons.org/licenses/by/4.0/\"><img alt=\"Creative Commons License\" style=\"border-width:0\" src=\"http://i.creativecommons.org/l/by/4.0/88x31.png\" /></a><br />This work is licensed under a <a rel=\"license\" href=\"http://creativecommons.org/licenses/by/4.0/\">Creative Commons Attribution 4.0 International License</a>.\n        \t</div>\n\n</div><!-- content -->\n</div><!-- main -->\n</div><!-- body -->\n\n<!--\t\t\t<br/><br/>\n\t\tCopyright (c) 2010 Journal of Natural Remedies\n\t\t\t\t<br /><br />\n\t\t<a rel=\"license\" href=\"http://creativecommons.org/licenses/by/4.0/\"><img alt=\"Creative Commons License\" style=\"border-width:0\" src=\"http://i.creativecommons.org/l/by/4.0/88x31.png\" /></a><br />This work is licensed under a <a rel=\"license\" href=\"http://creativecommons.org/", "ref=\"http://creativecommons.org/licenses/by/4.0/\"><img alt=\"Creative Commons License\" style=\"border-width:0\" src=\"http://i.creativecommons.org/l/by/4.0/88x31.png\" /></a><br />This work is licensed under a <a rel=\"license\" href=\"http://creativecommons.org/licenses/by/4.0/\">Creative Commons Attribution 4.0 International License</a>.\n        \t</div>\n\n</div><!-- content -->\n</div><!-- main -->\n</div><!-- body -->\n\n<!--\t\t\t<br/><br/>\n\t\tCopyright (c) 2010 Journal of Natural Remedies\n\t\t\t\t<br /><br />\n\t\t<a rel=\"license\" href=\"http://creativecommons.org/licenses/by/4.0/\"><img alt=\"Creative Commons License\" style=\"border-width:0\" src=\"http://i.creativecommons.org/l/by/4.0/88x31.png\" /></a><br />This work is licensed under a <a rel=\"license\" href=\"http://creativecommons.org/licenses/by/4.0/\">Creative Commons Attribution 4.0 International License</a>.\n\t-->\n\n<!-- Google Analytics -->\n<script src=\"http://www.google-analytics.com/urchin.js\" type=\"text/javascript\">\n</script>\n<script type=\"text/javascript\">\n_uacct = \"102562723\";\nurchinTracker();\n</script>\n<!-- /Google A", "ref=\"http://creativecommons.org/licenses/by/4.0/\">Creative Commons Attribution 4.0 International License</a>.\n        \t</div>\n\n</div><!-- content -->\n</div><!-- main -->\n</div><!-- body -->\n\n<!--\t\t\t<br/><br/>\n\t\tCopyright (c) 2010 Journal of Natural Remedies\n\t\t\t\t<br /><br />\n\t\t<a rel=\"license\" href=\"http://creativecommons.org/licenses/by/4.0/\"><img alt=\"Creative Commons License\" style=\"border-width:0\" src=\"http://i.creativecommons.org/l/by/4.0/88x31.png\" /></a><br />This work is licensed under a <a rel=\"license\" href=\"http://creativecommons.org/licenses/by/4.0/\">Creative Commons Attribution 4.0 International License</a>.\n\t-->\n\n<!-- Google Analytics -->\n<script src=\"http://www.google-analytics.com/urchin.js\" type=\"text/javascript\">\n</script>\n<script type=\"text/javascript\">\n_uacct = \"102562723\";\nurchinTracker();\n</script>\n<!-- /Google Analytics -->\n\n<div class=\"footer\">\n\t<div class=\"footeralign\">\n\t\t<ul class=\"left_footer\">\n                     <li><a href=\"http://www.informaticsjournals.com/index.php/index/search/authors\">Authors</a>&nbsp;&nbsp;| </li>\n\t\t"], "copyright__copyright__copyright": [" test and standard groups. Conclusion: Piperine significantly reduced not only body weight, fat mass, triglyceride and glucose levels but also improved sensitivity of exogenous insulin. The above results suggest that piperine has significant anti-obesity, antidiabetic activity and also improved insulin sensitivity.\n\nKeywords\n\nObesity, Diabetes, Insulin, Piperine, High-Fat Diet, Sibutramine.\n\nSubject Discipline\n\nPharmacy and Pharmacology\n\nFull Text:\n\nRefbacks\n\n  \u2022 There are currently no refbacks.", " test and standard groups. Conclusion: Piperine significantly reduced not only body weight, fat mass, triglyceride and glucose levels but also improved sensitivity of exogenous insulin. The above results suggest that piperine has significant anti-obesity, antidiabetic activity and also improved insulin sensitivity.\n\nKeywords\n\nObesity, Diabetes, Insulin, Piperine, High-Fat Diet, Sibutramine.\n\nSubject Discipline\n\nPharmacy and Pharmacology\n\nFull Text:\n\nRefbacks\n\n  \u2022 There are currently no refbacks.", " test and standard groups. Conclusion: Piperine significantly reduced not only body weight, fat mass, triglyceride and glucose levels but also improved sensitivity of exogenous insulin. The above results suggest that piperine has significant anti-obesity, antidiabetic activity and also improved insulin sensitivity.\n\nKeywords\n\nObesity, Diabetes, Insulin, Piperine, High-Fat Diet, Sibutramine.\n\nSubject Discipline\n\nPharmacy and Pharmacology\n\nFull Text:\n\nRefbacks\n\n  \u2022 There are currently no refbacks.", " test and standard groups. Conclusion: Piperine significantly reduced not only body weight, fat mass, triglyceride and glucose levels but also improved sensitivity of exogenous insulin. The above results suggest that piperine has significant anti-obesity, antidiabetic activity and also improved insulin sensitivity.\n\nKeywords\n\nObesity, Diabetes, Insulin, Piperine, High-Fat Diet, Sibutramine.\n\nSubject Discipline\n\nPharmacy and Pharmacology\n\nFull Text:\n\nRefbacks\n\n  \u2022 There are currently no refbacks.", " test and standard groups. Conclusion: Piperine significantly reduced not only body weight, fat mass, triglyceride and glucose levels but also improved sensitivity of exogenous insulin. The above results suggest that piperine has significant anti-obesity, antidiabetic activity and also improved insulin sensitivity.\n\nKeywords\n\nObesity, Diabetes, Insulin, Piperine, High-Fat Diet, Sibutramine.\n\nSubject Discipline\n\nPharmacy and Pharmacology\n\nFull Text:\n\nRefbacks\n\n  \u2022 There are currently no refbacks."]}