Original Research

High incidence of cisplatin-induced ototoxicity in paediatric patients in the Western Cape, South Africa

Mukovhe Phanguphangu, Lebogang Ramma
South African Journal of Oncology | Vol 2 | a41 | DOI: https://doi.org/10.4102/sajo.v2i0.41 | © 2018 Mukovhe Chad Phanguphangu | This work is licensed under CC Attribution 4.0
Submitted: 09 April 2018 | Published: 23 July 2018

About the author(s)

Mukovhe Phanguphangu, Faculty of Health Sciences, University of Cape Town, South Africa; Faculty of Health Sciences, University of Fort Hare, South Africa
Lebogang Ramma, Faculty of Health Sciences, University of Cape Town, South Africa


Share this article


Abstract

Background: Fourteen million new cancer cases are reported annually, and up to 10% of those involve children below 15 years. Cisplatin, a commonly used anti-cancer drug for its high success rate, is associated with ototoxicity. Cisplatin-induced ototoxicity is characterised by permanent bilateral severe-to-profound hearing loss. Hearing loss, when occurring during childhood, can impact negatively communication development, scholastic performance and quality of life.

Aim: To determine the incidence of cisplatin-induced ototoxicity in paediatric oncology.

Setting: A retrospective records review of paediatric oncology patients who underwent cisplatin-based chemotherapy and had ototoxicity monitoring from January 2015 to December 2017 at a children’s hospital.

Method: Data collected included demographic, cisplatin treatment and audiometric information. The data were analysed using descriptive and inferential statistics.

Results: A total of 49 records meeting the inclusion criteria were reviewed. Ototoxic hearing loss was found in 39 (80%) of the patients whose records were reviewed and the majority (56%) presented with a bilateral moderate-to-severe sensorineural hearing loss. Distortion product otoacoustic emissions were absent in 32 (67%) patients. Cumulative dose (> 200 mg/m2) was associated with higher incidences of ototoxicity (odds ratio [OR]: 1.81; 95% confidence interval [CI]: 0.67–17.34; p = 0.044). Younger patients (< 10 years) had higher odds of developing ototoxicity, but this was not statistically significant (OR: 4.00; 95% CI: 0.82–19.46; p = 0.085).

Conclusion: This study found a high incidence of cisplatin-induced ototoxicity in paediatric oncology patients. This is concerning because hearing loss during this age can have long-term negative impact on a child’s development and overall quality of life. Early identification of ototoxicity-induced hearing loss and appropriate intervention are highly recommended in this patient group.


Keywords

Cisplatin; ototoxicity; paediatrics; hearing loss; sensorineural; South Africa

Metrics

Total abstract views: 322
Total article views: 162


Crossref Citations

No related citations found.
{"cc_re__cc_re__cc_by_4_0": ["lication/xml\"/>\r\n\t<meta name=\"DC.Format\" scheme=\"IMT\" content=\"application/pdf\"/>\r\n\t<meta name=\"DC.Identifier\" content=\"41\"/>\r\n\t<meta name=\"DC.Identifier.pageNumber\" content=\"5 pages\"/>\r\n\t\t\t\t\t\t\t<meta name=\"DC.Identifier.DOI\" content=\"10.4102/sajo.v2i0.41\"/>\r\n\t\t<meta name=\"DC.Identifier.URI\" content=\"https://sajo.org.za/index.php/sajo/article/view/41\"/>\r\n\t<meta name=\"DC.Language\" scheme=\"ISO639-1\" content=\"en\"/>\r\n\t<meta name=\"DC.Rights\" content=\"Copyright (c) 2018 Mukovhe Chad Phanguphangu\" />\r\n\t<meta name=\"DC.Rights\" content=\"https://creativecommons.org/licenses/by/4.0\"/>\r\n\t<meta name=\"DC.Source\" content=\"South African Journal of Oncology\"/>\r\n\t<meta name=\"DC.Source.ISSN\" content=\"2523-0646\"/>\r\n\t<meta name=\"DC.Source.Issue\" content=\"0\"/>\t<meta name=\"DC.Source.URI\" content=\"https://sajo.org.za/index.php/sajo\"/>\r\n\t<meta name=\"DC.Source.Volume\" content=\"2\"/>\t\t\t\t\t\t<meta name=\"DC.Subject\" xml:lang=\"en\" content=\"Cisplatin\"/>\r\n\t\t\t\t\t\t\t\t<meta name=\"DC.Subject\" xml:lang=\"en\" content=\"ototoxicity\"/>\r\n\t\t\t\t\t\t\t\t<meta name=\"DC.Subject\" xml:lang=\"en\" content=\"paediatrics\"/>\r\n\t\t\t", "ract_title\">High incidence of cisplatin-induced ototoxicity in paediatric patients in the Western Cape, South Africa</h3>\r\n\t</div>\r\n\t<div id=\"authorString\"><em>Mukovhe Phanguphangu, Lebogang Ramma</em></div>\r\n\t<div>\r\n\t\tSouth African Journal of Oncology | Vol 2 | a41 |\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\tDOI: <a id=\"pub-id::doi\" href=\"https://doi.org/10.4102/sajo.v2i0.41\">https://doi.org/10.4102/sajo.v2i0.41</a>\t\t\t\t\t\r\n\t\t\r\n\t\t\t\t\t\t\t\t\t| \u00a9 2018 Mukovhe Chad Phanguphangu\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t| This work is licensed under <a target=\"_blank\" href=\"https://creativecommons.org/licenses/by/4.0\" >CC Attribution 4.0</a>\r\n\t\t\t\t\t\t\t\t\t\t\t<br />\r\n\t\t<b>Submitted:</b>  09 April 2018&nbsp;| <b>Published:</b>  23 July 2018\r\n\r\n\t</div>\r\n\t<br />\r\n\t\t\t<div>\r\n\t\t<h4 style=\"font-weight:normal;font-size: 11px !important;\">About the author(s)</h4>\r\n\t\t\t\t\tMukovhe Phanguphangu, Faculty of Health Sciences, University of Cape Town, South Africa; Faculty of Health Sciences, University of Fort Hare, South Africa<br />\t\t\t\t\tLebogang Ramma, Faculty of Health Sciences, University of Cape Town, South Africa\t\t\t\t</div>\r\n\t\t", "footerleft\"><!--<img src=\"/sajp/public/site/images/admin/logo.png\" alt=\"\" />--><span id=\"contactus\"><strong>African Online Scientific Information Systems (Pty) Ltd t/a AOSIS</strong><br />Reg No: 2002/002017/07<br />RSA Tel: 086 1000 381<br />International Tel: +27 21 975 2602<br />15 Oxford Street, Durbanville, Cape Town, 7550, South Africa<br />publishing(AT)aosis.co.za replace (AT) with @ <br /></span><span id=\"contactustnc\"><br />All articles published in this journal are licensed under the <a href=\"https://creativecommons.org/licenses/by/4.0/\" target=\"_blank\">Creative Commons Attribution 4.0 International</a> (CC BY 4.0) license, unless otherwise stated. <br />Website design &amp; content: \u00a92018 <a href=\"https://www.aosis.co.za\" target=\"_blank\"> AOSIS (Pty) Ltd.</a> All rights reserved. No unauthorised duplication allowed. <br />By continuing to use this website, you agree to our <a href=\"https://aosis.co.za/policies\" target=\"_blank\">Privacy Policy</a>.</span><div id=\"connect\"><a id=\"gplus\" href=\"https://plus.google.com/+AOSISPtyLtdCapeTown\" target="], "copyright__copyright__copyright": ["ic oncology patients. This is concerning because hearing loss during this age can have long-term negative impact on a child\u2019s development and overall quality of life. Early identification of ototoxicity-induced hearing loss and appropriate intervention are highly recommended in this patient group.\n\n\nKeywords\n\nCisplatin; ototoxicity; paediatrics; hearing loss; sensorineural; South Africa\n\nMetrics\n\nTotal abstract views: 322\nTotal article views: 162\n\n\nCrossref Citations\n\nNo related citations found.", "ic oncology patients. This is concerning because hearing loss during this age can have long-term negative impact on a child\u2019s development and overall quality of life. Early identification of ototoxicity-induced hearing loss and appropriate intervention are highly recommended in this patient group.\n\n\nKeywords\n\nCisplatin; ototoxicity; paediatrics; hearing loss; sensorineural; South Africa\n\nMetrics\n\nTotal abstract views: 322\nTotal article views: 162\n\n\nCrossref Citations\n\nNo related citations found.", "ic oncology patients. This is concerning because hearing loss during this age can have long-term negative impact on a child\u2019s development and overall quality of life. Early identification of ototoxicity-induced hearing loss and appropriate intervention are highly recommended in this patient group.\n\n\nKeywords\n\nCisplatin; ototoxicity; paediatrics; hearing loss; sensorineural; South Africa\n\nMetrics\n\nTotal abstract views: 322\nTotal article views: 162\n\n\nCrossref Citations\n\nNo related citations found.", "ic oncology patients. This is concerning because hearing loss during this age can have long-term negative impact on a child\u2019s development and overall quality of life. Early identification of ototoxicity-induced hearing loss and appropriate intervention are highly recommended in this patient group.\n\n\nKeywords\n\nCisplatin; ototoxicity; paediatrics; hearing loss; sensorineural; South Africa\n\nMetrics\n\nTotal abstract views: 322\nTotal article views: 162\n\n\nCrossref Citations\n\nNo related citations found.", "ic oncology patients. This is concerning because hearing loss during this age can have long-term negative impact on a child\u2019s development and overall quality of life. Early identification of ototoxicity-induced hearing loss and appropriate intervention are highly recommended in this patient group.\n\n\nKeywords\n\nCisplatin; ototoxicity; paediatrics; hearing loss; sensorineural; South Africa\n\nMetrics\n\nTotal abstract views: 322\nTotal article views: 162\n\n\nCrossref Citations\n\nNo related citations found.", "ic oncology patients. This is concerning because hearing loss during this age can have long-term negative impact on a child\u2019s development and overall quality of life. Early identification of ototoxicity-induced hearing loss and appropriate intervention are highly recommended in this patient group.\n\n\nKeywords\n\nCisplatin; ototoxicity; paediatrics; hearing loss; sensorineural; South Africa\n\nMetrics\n\nTotal abstract views: 322\nTotal article views: 162\n\n\nCrossref Citations\n\nNo related citations found."]}