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Eptapirone (F-11,440) is a very potent and highly selective 5-HT1A receptor full agonist of the azapirone family. [1]

34 relations: Agonist, Anxiolytic, Azapirone, Befiradol, Behavioural despair test, Binding selectivity, Buspirone, Cmax (pharmacology), Conflict procedure, Cortisol, Depression (mood), Dizziness, Dose (biochemistry), F-15,599, Flesinoxan, Growth hormone, Half-life, Human, Imipramine, Intrinsic activity, Ipsapirone, Ligand (biochemistry), Oral administration, Paroxetine, Partial agonist, Potency (pharmacology), Pre-clinical development, Rapid eye movement sleep, Serotonin, Side effect, Somnolence, Tandospirone, Thermoregulation, 5-HT1A receptor.

Agonist

An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

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Anxiolytic

An anxiolytic (also antipanic or antianxiety agent) is a medication or other intervention that inhibits anxiety.

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Azapirone

Azapirones are a class of drugs used as anxiolytics and antipsychotics.

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Befiradol

Befiradol (F-13,640; NLX-112) is a very potent and highly selective 5-HT1A receptor full agonist.

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Behavioural despair test

The behavioural despair test (or Porsolt forced swimming test) is a test, centered on a rodent's response to the threat of drowning, whose result has been interpreted as measuring susceptibility to negative mood.

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Binding selectivity

Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.

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Buspirone

Buspirone, trade name Buspar, is an anxiolytic psychotropic drug of the azapirone chemical class.

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Cmax (pharmacology)

Cmax is a term used in pharmacokinetics refers to the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administrated and prior to the administration of a second dose.

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Conflict procedure

The conflict procedure is an experiment widely used in scientific research to quantify anxiety levels through measuring changes in punished/unpunished responding.

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Cortisol

Cortisol is a steroid hormone, in the glucocorticoid class of hormones, and is produced in humans by the zona fasciculata of the adrenal cortex within the adrenal gland.

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Depression (mood)

Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, feelings and sense of well-being.

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Dizziness

Dizziness is an impairment in spatial perception and stability.

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Dose (biochemistry)

A dose is a quantity of something (chemical, physical, or biological) that may impact an organism biologically; the greater the quantity, the larger the dose.

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F-15,599

F-15,599, also known as NLX-101, is a very potent and highly selective 5-HT1A receptor full agonist.

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Flesinoxan

Flesinoxan (DU-29,373) is a potent and selective 5-HT1A receptor partial/near-full agonist of the phenylpiperazine class.

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Growth hormone

Growth hormone (GH or HGH), also known as somatotropin or somatropin, is a peptide hormone that stimulates growth, cell reproduction and regeneration in humans and other animals.

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Half-life

Half-life (t1⁄2) is the amount of time required for the amount of something to fall to half its initial value.

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Human

Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens) are the only extant members of the hominin clade (or human clade), a branch of the great apes; they are characterized by erect posture and bipedal locomotion, manual dexterity and increased tool use, and a general trend toward larger, more complex brains and societies.

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Imipramine

Imipramine (G 22355), sold as Tofranil and also known as melipramine, is a tricyclic antidepressant (TCA) of the dibenzazepine group.

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Intrinsic activity

Intrinsic activity (IA) or efficacy refers to the relative ability of a drug-receptor complex to produce a maximum functional response.

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Ipsapirone

Ipsapirone is a selective 5-HT1A receptor partial agonist of the piperazine and azapirone chemical classes.

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Ligand (biochemistry)

In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

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Oral administration

Oral administration (per os) is a route of administration where a substance is taken through the mouth.

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Paroxetine

Paroxetine (also known by the trade name Paxil among others) is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) type. Paroxetine is used to treat major depression, obsessive-compulsive disorder, panic disorder, social anxiety, posttraumatic stress disorder, generalized anxiety disorder and vasomotor symptoms (e.g. hot flashes and night sweats) associated with menopause in adult outpatients. Differences between newer antidepressants are usually fairly subtle and mostly confined to side effects. It shares the common side effects and contraindications of other SSRIs, with higher rates of nausea, sleepiness, sexual side effects, and weight gain. Discontinuing paroxetine is associated with a high risk of withdrawal syndrome. Paroxetine may be associated with a slightly increased risk of birth defects. Marketing of the drug began in 1992 by the pharmaceutical company SmithKline Beecham, now GlaxoSmithKline. Generic formulations have been available since 2003 when the patent expired.

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Partial agonist

In pharmacology, partial agonists are drugs that bind to and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist.

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Potency (pharmacology)

In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.

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Pre-clinical development

In drug development, pre-clinical development, also named preclinical studies and nonclinical studies, is a stage of research that begins before clinical trials (testing in humans) can begin, and during which important feasibility, iterative testing and drug safety data is collected.

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Rapid eye movement sleep

Rapid eye movement sleep (REM sleep, REMS) is a unique phase of mammalian sleep characterized by random movement of the eyes, low muscle tone throughout the body, and the propensity of the sleeper to dream vividly.

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Serotonin

Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

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Side effect

In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.

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Somnolence

Somnolence (alternatively "sleepiness" or "drowsiness") is a state of strong desire for sleep, or sleeping for unusually long periods (cf. hypersomnia).

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Tandospirone

Tandospirone (Sediel), also known as metanopirone, is an anxiolytic and antidepressant used in China and Japan, where it is marketed by Dainippon Sumitomo Pharma.

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Thermoregulation

Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different.

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5-HT1A receptor

The 5-HT1A receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).

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Redirects here:

C16H23N7O2, F 11,440, F 11440, F-11,440, F-11440, F11,440, F11440.

References

[1] https://en.wikipedia.org/wiki/Eptapirone

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