Immunoglobulin G-binding protein A - P02976 (SPA_STAA8)

 

Protein Feature View of PDB entries mapped to a UniProtKB sequence  

  • Number of PDB entries for P02976: 13
 
Function
Avidly binds the Fc region of immunoglobulins (Ig) from most mammalian species, in a non-specific aggregation reaction that can lead to host tissue damage (PubMed:4163007, PubMed:2938951) (Probable). Also binds the Fab region of Igs, in a region remote from the Ig light chain and the heavy chain constant region, i.e. not a typical Ig-antigen recognition (PubMed:10805799). UniProt
Pathway Maps
Maps:       
Reactions:
      ESCHER  BiGG
Domain
Each of the immunoglobulin-binding region repeats can bind the Fc region of an immunoglobulin (PubMed:2938951). Cell wall anchoring is confered by the LPXTG motif and following sequences (residues 482-516) which are necessary and sufficient to target other proteins to the cell wall (PubMed:1638631). The YSIRK-G/S motif in the signal sequence plays a role in the secretion efficiency for SpA, it may have a specialized recognition mode. UniProt
  • Other Gene names: spa, SAOUHSC_00069
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Data origin/color codes
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Data in green originates from UniProtKB  
Variation data (sourced from UniProt) shows non-genetic variation from the ExPASy   and dbSNP   websites.
Data in yellow originates from Pfam  , by interacting with the HMMER3 web site  
Data in purple originates from Phosphosite  .
Data in orange originates from the SCOP   (version 1.75) and SCOPe   (version 2.04) classifications.
Data in grey has been calculated using BioJava  . Protein disorder predictions are based on JRONN (Troshin, P. and Barton, G. J. unpublished), a Java implementation of RONN  
  • Red: potentially disorderd region
  • Blue: probably ordered region.
Hydropathy has been calculated using a sliding window of 15 residues and summing up scores from standard hydrophobicity tables.
  • Red: hydrophobic
  • Blue: hydrophilic.
Data in lilac represent the genomic exon structure projected onto the UniProt sequence.
Data in blue originates from PDB
  • Secstruc: Secondary structure projected from representative PDB entries onto the UniProt sequence.
Sequence Mismatches It is now possible to see information about expression tags, cloning artifacts, and many other details related to sequence mismatches.
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Validation Track

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Data in red indicates combined ranges of Homology Models from SBKB   and the Protein Model Portal  
The PDB to UniProt mapping is based on the data provided by the EBI SIFTS project. See also Velankar et al., Nucleic Acids Research 33, D262-265 (2005).
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