Neurofibromatosis Type-1 with Solitary Neurofibroma of Palate: A Rare Case with Literature Review

Sivaranjani Yeluri, Samatha Chittemsetti, Sravya Taneeru, Rajani Korlepara

Abstract


Neurofibromatosis is a genetic disease characterised by multiple neurofibromas usually inherited as an autosomal dominant variety. Neurofibroma is a neurogenic tumour which manifests either as a solitary nodule or multiple as a part of neurofibromatosis. Skin is the most common site of involvement and its presence in oral cavity is rare. Oral manifestations have been reported in only 4-7% of neurofibromatosis cases. The most commonly affected sites include tongue and buccal mucosa and the rare sites of occurrence being palate and maxillary-mandibular bones. This article presents a rare case of multiple neurofibromatosis associated with a solitary neurofibroma of the palate in a 60 year old female. 


Keywords


Hard Palate;Maxillary;Neurofibromatosis;Neurofibroma

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References


Shafer W, Hine L , Levy. Text book of Oral pathology. 7th edition. Elseivier; New Delhi: 2012. p 202-3.

Holt JF. Neurofibromatosis in children. Am J Roentgenol 1978;130(4):615-39.

Shklar G, Meyer I. Neurogenic Tumours of the Mouth and Jaws. Oral Surg Oral Med Oral Pathol 1963;16(9):1075-93.

Rupak S, Baby GG, Padiyath S, Kiran Kumar KR. Neurofibromatosis Type I with oral manifestations. e-Journal of Dentistry 2012;2(1):136-9.

Kobrin JL, Blodi FC, Weingeist TA. Ocular and orbital manifestations of neurofibromatosis. Surv Ophthalmol 1979;24:45-51.

Von Recklinghausen FD: On Multiple Fibromas in the Skin and their Relationship to Multiple Neuromas. Berlin; Hirschwald: 1882.

Munhoz EA, Cardoso CL, Tolentino ES, et al. Von Recklinghausen's disease - Diagnosis from oral lesion: Neurofibromatosis I. Int J Odontostomat 2010;4(2):179-83.

Pukara MM, Pukara SM, Borole BS. Huge solitary neurofibroma of the oral cavity a case report. J Oral Maxillofac Surg Med Pathol 2014;26:96–7.

Baden E, Teaneck NJ, Fischer RJ, Trenton NJ. Multiple neurofibromatosis and neurofibroma of the palate. Report of a Case. Oral Surg Oral Med Oral Pathol 1963;16:1356-64.

Baden E, Pierce HE, Jack̀son WF. Multiple neurofibromatosis with oral lesions. Oral Surg Oral Med Oral Pathol 1955;8(3):263-80.

Gutmann DH. The neurofibromatoses: when less is more. Hum Mol Genet 2001;10:749.

National Institutes of Health Consensus Development Conference: Neurofibromatosis. Arch Neurol Chicago 1988;45:575-79.

Neville WB, Damm D, Allen CM, Bouquot JE. Oral and maxillofacial pathology. 3rd Edition. Elseivier; Philadelphia; 2010. p 529-31.

Borberg A. Tuberous sclerosis and Recklinghausens neurofibromatosis. Acta Psychiatr Neural Stand 1951;71:I-239.

Preston FW, Walsh WS, Clarke TH: Cutaneous neurofibromatosis (Van Recklinghausen’s disease); clinical manifestations and incidences of sarcoma in sixty-one patients. Arch Surg 1952;64: 813-27.

Hankey GT. section of odontology. Von Recklinghausen's Disease with Local Tumour of the Palate. Proceedings of the Royal Society of Medicine. 1933;23-5.

Miles DA, Wright BA. Palatal Swellings Associated with multilesional Disorders: Report of Cases. J Oral Maxillofac Surg 1986;44:666-8.

Kumar CA, Jagat Reddy RC, Gupta S, Laller S. Oral hamartomas with von Recklinghausen disease. Ann Saudi Med 2011;31(4):428-30.

Jouhilahti EM, Visnapuu V, Soukka T, et al. Oral soft tissue alterations in patients with neurofibromatosis. Clin Oral Invest 2012;16:551–8.

Bharath TS, Krishna YR, Nalabolu GR, Pasupuleti S, Surapaneni S, Ganta SB. Neurofibroma of the Palate. Case Reports in Dentistry 2014;1-4.

Campos MS, Fontes A, Marocchio LS, et al. Clinicopathologic and immunohisto-chemical features of oral Neurofibroma. Acta Odontol Scand 2012;70:577–82.


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