The aim of the course is to get students acquainted with the basic principles of the action of the physiologically active compounds. The special accent is on the link between the chemical structure and the action mechanism. The overview of the kinds of receptor and the receptor-medicine interaction is given, as well as the detailed overview of the different pharmacokinetical agents.
The basic concept of pharmamaceutical medicinal chemistry: stereochemistry of drugs, physico-chemical ad biopharmaceutical properties, phamacokinetics, metabolism of drugs, the mechanism of drugs actions. The overview of different pharmacodynamic agents: drugs affecting the central nervous system; cardiovascular system, hormonal and immune system, chemotherapeutic agents.
H.P.Rang, M.M.Dale, J.M.Ritter, P.K.Moore, 5.Pharmacology, 5th Edition, Data Status, Beograd, 2005.