Each treatment had duration of 30 days. The starting dose was calculated from the ED50
(Barrera-Bailón et al., 2013) determined in our model and the estimated oral bioavailability
from other rodent species of each AED. On the first group, the AED were administrated on the
drinking water with 1% sucrose; the dose was calculated according with the weight and by the
quantity of daily water intake, which were measured every three days. On the second group, the
AED were dissolved in diluted honey in distilled water, and was administrated directly in the
mouth twice a day with a pipetman, according with the weight of each animal. In both groups,
the doses used were increased every two weeks, according to the response of the animals to the
drug, given the efficiency in annulling the seizure and the toxic effects. In the first group, the
doses used were PB: 20 and 40 mg/kg/day; VPA: 150 and 300 mg/kg/day; LEV: 50 and 100
mg/kg/day. In the second group, the doses used were: PB: 40 and 60 mg/kg/day; VPA: 300 and
600 mg/kg/day; LEV: 100 and 150 mg/kg/day.

### Language ###
English

### Assessment ###
Extract the initial doses of one specific drug (LEV) from the treatment protocol

### Query ###
What is the starting dose of Levetiracetam administered to treat seizures?
What is the starting dose of Levetiracetam administered to treat seizures?