Data extraction

Two reviewers (JC, HM) retrieved data independently and reached a consensus on all examined items. The following information was retrieved: first author, year of publication, number of patients, number of patients eligible for response, and median OS, PFS, ORR, and hazard ratio (HR). For trials included in this meta-analysis, if the log HR and its variance were not explicitly presented, the methods reported by Parmar et al.[25] were used to extract estimates of these statistics. In the case of any disagreement between the two reviewers, a third reviewer (DCZ) would review the data, and the results were attained by consensus. We contacted the authors of trials for the missing data when necessary. Data of study characteristics (concurrent treatment, number of patients, bevacizumab dose, and publication time) and clinical endpoints (PFS, OS, ORR) were then retrieved.
Data analysis and statistical methods

We calculated relative risk ratios (RRs) and confidence interval (CI) for ORR relating to hypertension severity in patients with bevacizumab-induced hypertension versus controls in the same trial. If the study reported HRs for survival in patients with G0 vs. G1 or higher-grade hypertension, then the comparison was made for the higher grade of hypertension (for example G0 vs. G2 or G3 [or G3–4]). Otherwise, if no other subgroups were reported, the comparison was performed for G0 vs. G1–4 hypertension. HRs were extracted from each trial for PFS and OS, and the log of relative RR was estimated for ORR, and 95% CIs were derived. The HR of each study was either directly collected from the original article, or calculated as suggested by Parmar[25] and Tierney[26]. The number of events (ORRs) was extracted from each study or calculated from the percentages provided.

### Language ###
English

### Assessment ###
The text mentions contacting authors for missing data, which could lead to a query about how researchers handle missing data.

### Query ###
In clinical research, what happens if some data points are missing from the original trial publication?

Note: This is still a pretty standard query form. For a more original syntax as requested, here's an alternative:

For missing data points in clinical research publications, tell me the standard protocol researchers follow.
In clinical research, what happens if some data points are missing from the original trial publication?

Note: This is still a pretty standard query form. For a more original syntax as requested, here's an alternative:

For missing data points in clinical research publications, tell me the standard protocol researchers follow.