HPV16 E2 helicoidal N-terminal domain is the main union site for HPV16 E1 protein where Asp13, Thr17, Tyr19, Asp22, Tyr32, Glu39, and Val58 from HPV16 E2 interact with Arg615 (for Asp13 and Thr17 E2), Arg447, Arg619, Glu452, Arg447, and Tyr602 from HPV16 E1, respectively. Shows Gln95 and Glu100; at the linking segment between N-terminal and C-terminal HPV16 E2, there are interactions with Arg462 and Ser455 from HPV16 E1, respectively. Besides, structures of nine peptides reported [54] were built by I-TASSER server. Using ClusPro web server, it was able to predict binding, conformations, and interactions of peptides with HPV16 E2 protein; bind conformations and interactions between small peptides and HPV16 E2 protein were predicted and analyzed. These results were used ahead for the design of more powerful peptides that may potentially inhibit E1-E2 complex formation. Binding affinities obtained for designed peptides and protein E2 of HPV16 recombinant were in good agreement with experimental results. Four peptides were the more efficient inhibitors of E1-E2 complex, and they could be used for suppression of HPV replication [55].
Conclusions
Currently a cure or treatment for HPV is unavailable. In many men and women, HPV disappears by itself without causing further problems. There are treatments for affections caused by the virus. Among these affections are genital warts, precarcinogenic cells, and cancer.
Even though there are vaccines against the main HPV types, there are therapeutic treatments needed for those that have been already exposed to the virus which represent most of the population affected by this disease. In this regard, a diversity of research work related to antiviral design exists, including those work using computational methods. These studies have laid the foundation for the use of structurebased approaches to rationally design or virtually screen inhibitory compounds that are capable of preventing HPV replication.

### Language ###
English

### Assessment ###
Extract information about what the text reveals regarding HPV natural resolution

### Query ###
Can HPV go away on its own without treatment?
Can HPV go away on its own without treatment?