"i took this medication for just two days. my doc told me i did not have to wean off of effexor i could just start taking the trintellix on the day i chose.  i became severely depressed.  it hit me like a load of bricks.  sobbing, feeling helpless, hopelessness and that my life was just not worth living.  i was shocked at how fast these feeling came upon me  i have never experienced something like this before and i have been on several antidepressants over the years.  i also had severe nausea and diarrhea for over 24 hours.  the third day, yesterday i went back to the effexor.  today i finally feel like myself inside and out.  this medication was not for me!"