"i have been on depo provera since i was 18, so about five years. i have had no issues with it. i have not had a period in years (before i had terribly heavy periods), i did not experience any weight gain, do not have trouble staying fit, and do not experience any mood/personality swings. i just don&#039;t like that it&#039;s likely weakening my bones, but i try to stay on top of that with calcium/d supplements. however, i do wonder if it&#039;s had a negative effect on my sex drive, but that&#039;s inconsistent and i have nothing to compare it to since i got my shot as soon as i became sexually active, so it&#039;s hard to say."