"i&#039;ve never had acne and i cannot seem to get rid of it. i&#039;m sure it&#039;s because of the depo provera as it started shortly after my first injection. i am in my 30&#039;s and an active runner. my hips and knees seem to be much more sore after runs after i started the depo. i also have osteoporosis in my family and that is not helping my bone density situation. on the positive side, it&#039;s easy to take, stops my periods and i lost weight on it. all that being said, this will be my last cycle as the convenience is not worth brittle bones or a face full of acne."