"i have been on pretty much every antidepressant that is out there.  nothing has really helped and the few times i felt a slight improvement in my condition, the side effects outweighed the benefits.  pristiq has been totally different.  within a week of starting it i see a positive change.  my overall mood is better, i have more energy, and i am more productive.  also, when my mood does take a dip, it seems that the &quot;bottom&quot; has been raised.  in other words, the lows aren&#039;t as low as they once were.  i have only been on it a couple of weeks and i am told that i still may not be experiencing the full benefit, which is great considering how much better i already feel.  no side effects whatsoever.  very grateful for this medication."