"i have pain in back, hands, knees, hip, ankles, etc.  do to an arthritic condition.  it takes about an hour for it to kick in, and lasts about 2 to 3 hours and the pain starts to come back.  i take 2 in the morning and try to last 12 hours to take 2 in the evening, but it is not working so good lately. in about 5 hours after taking the pills, i am back to all the pain.  i am going to check with my doctor to see if i can also take 2 in the afternoon."