"i was given this medicine for depression and anxiety. i have experienced no negative side effects in the 6 years that i have taken sertraline (zoloft). compared to others like it, this one has been the best fit for me. before taking sertraline, i tried prozac, but hated feeling nauseated constantly. the only negative thing about this drug is that after a couple years, i notice that i have to go up a dosage because it seems less effective. i will notice my anxiety and depression more so than usual, but it is easily fixed with an increase. i started out at 50-100 mg, shortly being bumped up to 150 mg a day. now, i am taking 200 mg a day and have been for over a year and a half. overall good experience."