"i have been on opana ir for 4 months now. i have severe migraines due to a cyst on my brain along with 2 bulging discs in my neck. it works ok but i also have stadol nose spray if the opana doesn&#039;t help. i&#039;m on 5mg 2x a day. i honestly need stronger but since it&#039;s migraines he won&#039;t up it. i would recommend it for small pain."