"diagnosed with depression/anxiety 10 years ago. have practically been on every ssri, snri, seroquel, all kinds of benzos (do not recommend- highly addictive!)  i felt so frustrated that none of the anti-depressants were working for me and avoided tricyclics for fear of weight gain. last week i finally realised that i need serious help as i was planning suicide. i&#039;m back on 100mg endep and 25mg seroquel if needed at night. i sleep fantastic, wake up feeling so refreshed. sleeping makes a huge difference, and the funny thing is now that i&#039;m feeling good, i&#039;m out of bed and exercising. i know it&#039;s scary to think about weight gain but it really is different for everyone and it&#039;s worth a shot! endep&#039;s been the only one for me. good luck!"