"i have been on the depo shot since i was 15! (11 years now) i love the shot i have never had an issue, after my first couple weeks on it i never got a period again unless i missed a shot and had to wait for a period to get it again. i swear by it one of the greatest thing you don&#039;t forget to take it daily no cramps no period nothing up your private area. until this past year, issues i have been having all added up and led to this shot. i&#039;m 26 years old and have osteoporosis that of an 80 year old, the smaller of my breast became 2 sizes larger, my migraines increased to weekly with vision loss, itchy sore breasts, random stomach pains and nausea. also i have not changed my eating habits or daily routine i have out on 25lbs in the past 6mon."