"i have severe depression to the point i feel so angry i don&#039;t want to talk to anyone and i stay in my room. i started pristiq 3 weeks ago and after 2 weeks i almost stopped taking this medication because my irritability got so bad for three days. like i said i did not want to talk. then it just kicked in and i actually took my kids to the park and we played it. doesnt sound like a big deal but for me it was. i can&#039;t remember the last time i did this without forcing myself. my husband actually told me today that i&#039;m acting like the wife he married. i just hope i stay this way. so sorry to ramble but i feel great. i can&#039;t remember the last time i felt this good and i&#039;m not just going through the motions."