"i have been taking this drug for two years now. i take a 20mg pill twice a day. i also have 8 norcos a day if needed for breakthrough pain. i have severe crohns disease and these medicines have been the best thing that has happened to me. my frequent bathroom trips are now maybe only twice a day. they also help me have an appetite. my major pain results from irreversable avn of my elbows and knees. before this medication i could not get out of bed due to the severe pain."