"i&#039;m 47 and heterozygous for both mthfr mutations. i just came out of a deep, dark depression with the help of effexor. i started taking 0.5 milligrams of methyl folate (yes, a very low dose) about a month ago. even this small amount of methyl folate (in combo with methyl b12) affects me deeply and immediately. i take it before 8 in the morning, and it still influences my sleep that night. i have never been an active dreamer, but on methyl folate, i dream a lot. i seem to feel more awake and active in the afternoons, as well. i agree with the commenter about being on methyl folate for a period of time before deciding if it works for you. you may feel the effects immediately, or later on. there may be ups and downs."