"i recently was diagnosed with bpd. i have suffered from depression, fear of abandonment, and suicidal idiologies since i was a teenager. last october i had a total left knee replacement. the surgeon put me on tramadol up to 8 a day. i never took that many but i did notice a change in my mood and depression. while not a panacea, tramadol (50mg) 2x a day has made a significant improvement in my symptoms especially since i am going through a breakup with my significant other."