"i have been on pristiq for the past 12 months. i started on 50mg and went up to 100 mg after about 3 months. the side effects were terrible for the first two weeks. i have no side effects now except insomnia - however i have had insomnia for many years, i just have to make sure i have pristiq as soon as i get up. i am a much happier and relaxed person and it helped save my marriage. my husband is a saint but only a saint can take so much :)"