"my pain doctor put me on zohydro after i tried hysingla (worked great for a couple weeks, then only lasted about 8-12 hours - which can&#039;t work for a once every 24 hour medicine) and after i had been on percocet and hydrocodone at varying dosages and frequencies. ive had chronic back pain for 5+ years. i&#039;m so glad i got to try this medicine, it has changed my life. it&#039;s very expensive ($300+ per prescription before meeting my deductible), but it&#039;s totally worth it in my mind. it doesn&#039;t give you the annoying &quot;high&quot; that you get from short acting pain medication, no fuzzy thoughts, no exhaustion. medicine usually lasts the prescribed 12 hours and takes about 50-80% pain level away."