"weight gain, severe depression during pms and intense itching. i was on loestrin previously and it was great for 2 months. i had no acne, my periods were better. as of the third month i was itching uncontrollably and was told it was dry skin but the itching coincided with the time i took the pill. i went off the pill for a year then my doctor put me on loloestrin trying to reduce the hormone. i&#039;m not sure if weight gain was connected to that. i was having 2 periods a month. after 8 months of that, my doctor put me back on loestrin. i hoped it was a bad reaction to one pack before. i had debilitating depression at least one day mid month and one during pms. during the second month, the itching came back. i always itched 20 minutes after"