"well i&#039;m on day 9 of contrave. the 1st week with the 1 pill a day, i felt absolutely no difference. now that i have taken 2 days of the one pill in the morning and one in the evening, i feel slightly depressed and i have headaches. now i can&#039;t completely say it&#039;s the side effects of the medicine because my monthly cycle is upon me as well. so i&#039;m going to push through the depression and pray for the best. my starting weight was 181 and i&#039;m down 3 pounds even with the bloating of mother nature. i notice i pee alot more but once again tht may not be the medicine. week 3 i should be able to see how this medicine is effecting me"