"i&#039;ve taken zoloft for several years: once to help with ocd when i was younger and more recently to help with depression. overall i definitely experienced less crying and general hopelessness on zoloft. i still had my bad days but in general it&#039;s manageable. the biggest side effect was the weight gain. i gained about 20 lbs in a year. i also felt like i sweat easier on this medication, especially my palms. this was pretty minor though. i&#039;m switching to another medication due to the weight gain and i will say the withdrawals from zoloft are tough. my emotions were really heightened and anything could make me cry. be sure to tell your loved ones that you&#039;ll need some extra support as you taper off."