"i&#039;ve only been on fluoxetine now for 12 days at 20mg. i have a feeling i&#039;ll be going up to 40mg soon. nothing much yet except i have noticed i don&#039;t &quot;blow up&quot; as much at everyone but it&#039;s  only 12 days. you need 3-4 wks to see really. i&#039;ve tried lexapro  (sleepy all time &amp; wt gain)&amp; sertraline  (went toxic in my body, liver enzymes went up, constant diarrhea, major wt loss) &amp; lastly cymbalta  (helped with pain but not mentally and withdrawals were horrible). so antidepressant #4. i hope this one works! i do have loose bowels a lot in morning but take 1 loperamide everyday. that&#039;s all really except sometimes anxiety goes up. exercise will help."