"tried fluoxetine 20mg for a month.  absolutely did not work for me!!! i lost a few pounds which was water weight but gained it right back and some.  made anxiety,  obsessive thoughts worse,  depression worse too. got to a point where i thought i was gonna walk right out of my job.  stopped taking it a day ago and i already feel better,  maybe even hypomanic.it gets a 2 instead of 1 cuz it allowed me to sleep. i will be starting a combo of venlafaxine 75mg and bupropion 150 mg sr in a few days.  hopefully i won&#039;t resist this treatment. good luck everyone!"