"i am taking this along with buspar for my anxiety and depression. i only had anxiety so i was only taking buspar, but it seems as though buspar took away the anxiety and brought on depression. i&#039;m against taking ssri&#039;s or other antidepressants, so i asked my doctor first about possible interactions, then bought some st. john&#039;s wort. ever since, it hasn&#039;t happened to me anymore. i also have no side effects at all from it. some people say it will give u headaches, but i&#039;ve never had one. i personally believe that if u truly need this, there will be no headaches because your body needs it. but who knows, that&#039;s just my personal opinion :) it doesn&#039;t hurt to try it!"