"the positive: it has an almost immediate effect, from day one there&#039;s a lift in mood. effexor xr also gives a feeling of energy, both mental and physical. i&#039;ve also noticed a significant decrease in my social anxiety, i can talk to anyone without feeling nervous -  this &#039;extra&#039; effect began, again, on day one.                                     the negative: slight feelings of nausea with a definite decrease in appetite. i don&#039;t really enjoy my meals as much while on effexor. i&#039;ve also noticed a form of a insominia since starting - early awakenings and not being able to get back to sleep."