"i&#039;ve been taking bupropion for depression about 5 years and my doctor added lorazapam about 6 months ago for anxiety. i take 1 mg usually once a day although sometimes the day may call for a second dose. i try to wait until late in the day to take it, since i also take rozerum for sleeplessness. lorazapam usually works in about 20 minutes to calm things down but probably half the time i may not realize any change. rozerum alone at bedtime gives me 3-4 hours sleep but by taking lorazapam a few hours sooner i get 5-6 hours sleep. no noticeable side effects."