"i have been on zoloft for about two months for disthymia (constant mild depression), however i had about a 2 week gap where i wasn&#039;t taking it.  i was prescribed 50 mg, but since my side effects were pretty heavy at first, i decided to only take 25 mg for a while to start off.  i wasn&#039;t aware that 50 mg is the threshold of therapeutic effectiveness, so by taking 25 mg at a time i may have just been wasting it.  however, after taking it for the first month, i thought i noticed myself smiling and laughing more (a rare thing for me).  i am back on 50 mg, and i really hope that it helps me to feel happiness and excitement again in appropriate situations, where usually i will barely raise an eyebrow."