"i have been taking this off and on for 13 years. it greatly helps with my depression and mood. however, i&#039;ve developed anxiety and this does nothing for it. if you are willing to take the meds and wait for your depression to get better, it will help. usually takes 4 weeks to kick in to full swing. i don&#039;t think i&#039;d still be here if it weren&#039;t for these medicines."