"today is my third day on tenuate. i am taking the 75 mg once per day and have found that it works really well when i take it on an empty stomach with a full glass of water. i lost about 30 lbs on my own and then got stuck because i could not overcome being hungry all the time. so i went to a weight loss clinic and was prescribed this pill. in the last three days, i have had so much energy, no problems sleeping and my appetite has decreased enough that i can stick to my 1100 calories per day with no problem. i am already down 8 lbs. i know i won&#039;t lose like this every week, but it is nice to be out of the rut i was in!"