"at first i had a pain in my left hand while taking it and almost stopped. glad i didn&#039;t because after a couple of days this went away (mostly) and i started feeling the good effects, most notably is i didn&#039;t feel tired during the day, that was a part of my depression so this did have anti-depressant effects on me. i was happier doing everyday things like washing the car, i started cleaning the house at random and found it enjoyable. i do get an occasional headache or pressure would be a better description, so i occasionally take 1 advil with it and it goes away. i noticed, for me, this drug only works when you take it as prescribed."