"i have battled cystic acne since i was twelve years old. i&#039;m 33 now and finally using something effective. i take 50 mg twice per day and over a three month period the breakouts have decreased. i have not experienced any weight gain or other side effects while taking spironoloactone. i am also using retin a gel at night and wash with panoxyl twice a day. i feel more confident now that my skin is clearer. i&#039;ve tried almost every product there is from murad to neutrogena, this is the first time in a long time i&#039;ve experienced little to no breakouts."