"i have suffered from anxiety and depression for many years and recently have been advised that i needed to change my medication. i was on paroxetine for about 10 years and am on day 9 of pristiq. nausea, insomnia and dizziness have been the worst side effects however i was taking it in the morning and it was making me so sleepy that doctor suggested taking it at night. i noticed a huge difference in my mood yesterday having not taken it in the morning, i was extremely anxious and cried all day. i took it last night and immediately felt more relaxed so i am hoping that in a few days the sadness and despair subside. i have also had a decrease in appetite probably due to the nausea. i am going to stick with it and hope for the best."