"i use this once in the morning and once at night. i have been doing this for about a week now. my acne went from severe to nothing. absolutely acne free in one week. i have read that some people are having issues getting burned on the med after using once a day. they tell you this.. put it on for an hour... wash it off for the first week. but it had no negative effects for me. i just jumped in twice a day and i am happy i did so. if you want to take some risk and are in a hurry to get completely acne free in a 1 week. go twice a day.. don&#039;t apply any other things to your face. no washes. that could irritate it more. just go twice a day, one week and hopefully you won&#039;t have any acne. then you can drop down to nightly as a maintenance dose."