"i was put on tri-sprintec to help with my moderate acne. it worked very well! to my surprise my skin has been clear and blemish free for months. at first i did gain 10lbs right to start with, which scared me because really, who wants to gain weight. but, i stuck it out and was happy with how it has been working. i am being taken off of tri-sprintec this week because it is interfering with my other acne prescriptions; causing yellowing of my eyes, swelling in my ankles, etc. granted these side effects wouldn&#039;t be necessarily happening without my acne medicines. so, bottom line tri-sprintec is a good birth control, works well, just not for me with my acne medicines. wish i could stay on it, but the swollen ankles aren&#039;t worth it."