"most antdepressant(ad) medications have been ineffective for me. my primary concern is anxiety with depression being also a concern. wellbutrin in my experience has been one of the few which isn&#039;t aweful. it&#039;s honestly no miracle worker and i&#039;m not sure ad&#039;s are the way to go. that said if your going to take an ad wellbutrin is well worth trying. i presently take 150mg but 300mg was most effective. pros: helpful on sexual side of things, weight-loss, helps a lot with feeling happier. cons: little or no effect on anxiety, slight weird feeling (i noted i should be sad yet i&#039;m not. i guess that&#039;s it doing it&#039;s job.), can cause insomnia (be careful what time you take), not available on pbs (in aus)."