"i am currently taking 30mg twice a day. i haven&#039;t been on it to long, roughly around 4 weeks. during my first few days to a week i had horrible headaches, which slowly started to ease off. towards the end of my 1st week i started with 2 side effects. dry skin &amp; dry lips. nothing to bad. around the middle of my 2nd week i started breaking out really bad. which was suspected. within that time frame i had a few crying spells just bc i felt so ugly. by week 3, my face started clearing up! i haven&#039;t had no other side effects. no depression. no mood swings really. i kinda stay bitchy. so that was nothing new. i absolutely love this medicine. i have suffered with acne since i was 14. i am now 25. i use aquaphor for lips and cetaphil face wash."