"when i first started effexor xr, it seemed to really help for a while.  after a while we had to increase the dosage to its maximum, and had to add the max 80 mg of prozac to keep me &quot;normal&quot;.  after about a year, i started having real problems with exhaustion and fatigue.  it took a lot of testing and doctors and finally two separate sleep studies to find that my deep sleep had been disrupted significantly -- essentially i was getting no restorative sleep, even when i slept for 8-12 hours!"