"took 9 mos to regulate. i&#039;ve been on this for almost 2 years now. i was prepared to wait because many years ago was on seasonale so i knew it would take 2-3 packs (each pack is 3 months) for results. dealt with spotting &amp; irregular bleeding in beginning. cramps went away with the first period. well worth the 9 mo wait bc now only 4 periods per year that last 3 days with light bleeding and zero cramps. im 42 yrs and a plus with camreselo is it gave me my sex drive back once it was regulated in my system. well worth the adjustment period!"