"i&#039;ve been on venlafaxine 300mg along with quetiapine, mirtazapine and pregabalin for major depression for around 7 years.augmentation therapy works for me.  it&#039;s not perfect, but this level of venlafaxine along with the other meds has kept me alive. i&#039;m not getting better, but i&#039;m certainly more stable and not going downhill and not suicidal. so in conclusion, don&#039;t be scared of meds, they may just save your life."