"i ended up on escitalopram about 2-3 years ago because the previous med (effexor xr) was causing steady weight gain i just couldn&#039;t manage anymore (50+ lbs. in 9 months). and this has hands down been the best med i&#039;ve ever been on. it doesn&#039;t seem to affect my weight at all, and i feel completely &quot;normal&quot; for possibly the first time since childhood (about 30 years ago). i&#039;m on 20mg, as 10mg just wasn&#039;t quite cutting it, and my doctor also later added buspirone to help with some lingering anxiety. i found effexor to be generally more effective for anxiety, and lexapro more effective for depression, so i think this escitalopram/buspirone combo works well for me."