"opana has worked better than anything i have been prescribed. i have several bulging discs, 4 in the lower back and 4 mid back. i was taking 3000 milligrams of vicodin daily, 8 to 10 x 325 mg tabs.  now, i take 2, 20 milligram opana daily, and only 2 or 3 vicodin as needed.  be sure to take opana on an empty stomach, and don&#039;t eat for about 2 hours.  opana is incredible, my next doctor&#039;s visit, i will request a slightly higher dose, and quit the vicodin all together.  thank you opana!"