"i battled with bipolar i since 1992 but never experience major depression until mid-2009 and it was terrible, lots of crying, despair, horrible guilt, just hating myself.  i tried 2-3 anti-depressant when i finally found a m.d. who would let me try one (they are so concerned you will spiral up into a manic attack).  i then tried cymbalta (60mg) and the depression is most days just gone.  i have had some bad days like everyone; a few times when crying, regretting etc. would start, it seems it was capped off and subsided quickly. i continue to have significant constipation and hand tremor. i eat a lot more fiber in my diet and take 2 natural fiber pills a day to help with the constipation. cutting back on caffeine helps the hand tremor."