"i tried effexor xr after most of the ssris i recently tried gave me diarrhea for more than just the initial adjustment period. i tend to be more on the anxious side of life and the ssris seemed to treat that better than effexor, but i cant be in the bathroom all day. 75mg/day works well for me currently. i was on 150mg for a year which worked well, but then suddenly my anxiety and obsessive thinking was coming back.the doc upped dose to 225 and i got way worse, so we lowered it and boom. way better. &quot;less is more&quot; worked for me this time. effexor xr also has less side effects for me regarding fatigue, hunger, weight gain and sexual side effects. as a woman this is a huge perk. mental health- the struggle is real! good luck!"