"helps with insomnia if i take it with other sedatives. initially i found it very stimulating. i have chronic fatigue syndrome/me, irritable bowel syndrome-d, depression and anxiety. i take 500mg in total throughout the day. my main reason for reporting my experience is that it helps so much with my ibs-d. i have taken many anti-diarrhoea medicines with little effect.i can now eat foods that caused cramping and urgent diarrhoea. i now also take laxatives every day. i much prefer trying to manage constipation than the uncontrollable urgent diarrhoea. the ibs-d has been so crippling and i have had it for more than 25yrs. it started very soon after i had my severe viral infection that caused the cfs/me"