"i started  taking phenermine on september 11, 2015. i weighed in at 253.4 when i started.  today is my 3rd day and i&#039;m  down to 250.0. i have noticed a change in my appetite  as well as increased energy level. i did get a slight headache on day two but i think it was from not drinking enough water. i hope to lose 15-20 lbs the first month and 90 over all.  i will update my progress in a few days."