"i have had periods of rather severe depression for basically my whole adult life but never tried a medication. i recently decided to try one and asked my rheumatologist just as we were finishing up.  she didn&#039;t ask me why i wanted it thus avoiding seeing me cry and did the prescription. i saw an amazing change over the following few weeks - not only mood change, no more crying spells, best sleep i have had in 20 years or more, but i no longer obsess about things i cannot change. i have been able to give up added sugar. i have lost a bit of weight down to 103lbs and my (how do i say this) - my intestines are working as they have not done since childhood.  i am amazed! "