"been on pristiq for a month now changing from cymbalta. cymbalta did nothing for me, pristiq is starting to help. have had unresponsive major depression along which chronic anxiety for 5 years now. have tried so many antidepressants of which none were effective for the depression and anxiety. but had a huge serving of various side effects as most mentioned.

now, anxiety under limited control, depression is lifting but is hard to say how much. i had forgotten what &quot;normal&quot;  feels like. so far p is helping but a long way to go."