"i started on zoloft due to a number of losses-deaths in family &amp; a breakup. while they say it may take weeks to fully enter your system, i would say for me it took a few days to feel it. mine was a lower dosage, 25mg i believe but it still worked well enough to jump-start my life again. i would no longer dwell on the negative things, however sometimes it was equally hard to concentrate on important things, as my mind would go &quot;spacy&quot; on occasion. slight dry mouth at first but it went away. i became more social and dated more. the downside- while interest in sex never waned, it would take a long time to perform. you would think that would be a good thing, but after 20 minutes, most ladies started glancing at the clock. so much for dating!"