"i&#039;m 43 yrs old and i have struggled with acne since my teens. i&#039;ve tried many over the counter and prescription remedies. about four months my dermatologist prescribed doxycycline, clindamycin in the morning and differin at night. it took about a month before i started seeing a difference. this is the most effective treatment i&#039;ve ever used. i have no active pimples. i do have some spotting from prior breakouts. my dr. prescribed hydroquinone also for the spots,but advised me to wait until the acne calms down before treating the spots. i barely needed to treat the spots by then the had lightened from the differin!  overall the texture of my skin looks better. however i do have 1 con. i have developed a light streak on one cheek."