"i take 200 mg (the maximum recommended dosage) of zoloft to help with my depression. it hasn&#039;t helped very much, however. i still get very depressed sometimes, and it hasn&#039;t made much of a difference with my anxiety either. i take it in conjunction with risperidone. for some reason my psychiatrist seems to think the thing to do is to keep increasing the medication, even though i feel no noticeable difference."