"been on duloxetine for 4 weeks now at 30 mg. first day had terrible diarrhea,  then felt groggy and almost in a dream like state for the first week. i was prescribed cymbalta for migraines and general anxiety. week 2 started to feel more normal but my anxiety was worse (to be expected). week 3 i  noticed my migraines were less frequent and i tolerated the pain better, also started feeling happier and less anxious. week 4 my anxiety is almost gone n migraines have gone from daily to maybe every 3 or 4 days and are less severe. worth the first two weeks of feeling crappy."