"started at 150 mg, took half a day and felt like a new person - it changed my life.  quickly found i need to take the full tablet to get the same effect.  three months ago doctor increased to 250 mg, take full tablet but the effect only lasts 3-4 hours.  your body becomes immune and needs more and more.  and now i &quot;crash&quot; early afternoon and become very  depressed.  took appetite away, lost 20 lbs in little over a year."