"you have to be aware of the positives and negatives of any medicine you take. even tylenol. i have found that saphris has worked pretty well despite a few side effects that i&#039;ve learned to live with. my doc tried me on latuda first because i was a bit concerned with taking something sublingually. i should have tried saphris first. latuda had me wanting to jump out of my skin and made me want to eat all of the time. i gained 50 pounds in the six months i was on latuda and have lost all but 7lbs on saphris.  i don&#039;t mind the numb tongue because it goes away. i am even used to the taste now. overall saphris gave me my life back."