"my experience with depo has been wonderful! i had horrible cramps and long heavy periods before i started the shot. after about 5 months i stopped having a period at all which was great. no surprises! also i lost about 13 pounds on it. i was previously on ortho tri cyclin lo-fe. the pills made me gain weight, the weight loss without trying was fabulous. i dont feel tired or achey. the only negative was i have had some acne return, it&#039;s nothing that a touch of makeup can&#039;t fix... but from having 100% blemish free skin to a few pimples is a little annoying. i will continue to stay on the shot until i decided to start thinking about having kids. until then, i&#039;ll deal with a couple pimples and enjoy my skinny, period free life:)"