"i had weened off effexor in october as i was tired of the side effects. i wanted to go the natural route with exercising and eating better to see if it would help.  unfortunately i have been going through a hard time and needed something to help me through this. i started on wellbutrin xl , 150 mg, about 2 weeks ago. i honestly can&#039;t tell if it is helping or not. i feel about the same mood wise ...very sad, crying a lot, no appetite, sense of failure and no hope. i know things can&#039;t change immediately but was hoping i could be one of the individuals that experience positive results. hope this changes eventually."