"took this for the better part of 10 years as i can&#039;t take estrogen (19-29) and had zero major issues. i got my period consistently every month except one. had some of the more mild side effects like moodiness and nausea around my period. i still ovulated almost every month. i do think there are some other side effects i may notice as i&#039;m coming off of it now to try to get pregnant, but nothing has been severe enough to interfere with my quality of life or comfort."