"i was struggling with major depression and ocd and tried several antidepressants before my endocrine doctor found out i had the gene mutation.  the first dose of deplin of 15 mg was too much for me and i felt edgy and anxious.  i then tried the 7.5 dosage and honestly felt like myself for the first time in months.  clarity, energy and focus!  one side effect was headaches and then i went online to mthfr.net and learned i needed to supplement with a few things to feel better.  this has been answer to prayer for me.  i am on 2.5 mg of lexapro and hope to get off of it in the next 6 months.  wish someone would have told me about this sooner!!"