"i  started on 60 mg of noritripteline at the age of 65 as a replacement for cymbalta, which i could no longer afford.  i found that when it was combined with 100 mg of sertaline (zoloft).  this combination gave me the greatest relief from the chronic depression i have suffered from since the age of 15.



but i was not aware of its anticholinergic effects on older people which manifested at age 67 when i began to experience problems walking,  repeated falls, lethargy, mental confusion and memory problems.  in addition to the noritripteline,  i was also taking benadryl (over the counter) to aid with sleep at night,  another anticholinergic drug. both medications can be detrimental in older population groups and result in my symptoms."