"when i started zoloft i had tremors.  my initial dose was 100mg, but after a few months i still had issues with anger and sadness.  my dose was increased to 150 mg and i seemed to be doing better.  my sad thoughts went away.  i had no desire for sex at all.  i still felt like i could sleep all day and all night every day.  i just recently switched to wellbutrin xl.  it was hard on me coming down from the zoloft.  i became more sad, depressed, angry, hostile.  a couple of times i had suicidal thoughts (didn&#039;t have before or while taking zoloft).  pros no weight gain with zoloft.  cons had to cut back on my caffeine, no sex drive at all, and just didn&#039;t quite work good enough for me."