"took my first 10 mg brintellix just before i went to bed at around 11:00 p.m.  it&#039;s now 6:30 a.m. &amp; i haven&#039;t slept.  not a wink.  going forward, i will definitely be taking them in the mornings.  i just arbitrarily rated it as a &quot;5&quot; since i&#039;ve only taken one.  other than being wired, i haven&#039;t had any negative side effects.  i never hold out much hope for any new antidepressant, though.  it seems that nothing works for me.  i will take brintellix for at least a couple of months before deciding if it works &amp; whether or not i want to continue taking it.  the cost will also factor into this (in a big way).  my dr. gave me a month&#039;s worth of samples &amp; a card for some sort savings program..."