"i have had ocd and anxiety for 26 years, prozac worked for about 7 yrs. then pooped out, zoloft was next.  it lasted another 7 yrs then pooped out. then came lexapro and i only got 2 yrs out of it and then had my first major depressive episode.  lasted 9 mnths while dr. was trying effexor xr.  it helped the depression, but not the ocd.  went to a new dr. and was put on viibryd starter pack and when i was up to 40 mgs. i had my life back. recently, my doc upped the dosage to 60 mgs. because i was still obsessing about getting the depression back.  been on the 60 mg. dose for a few days and it actually made my ocd and anxiety worse, however, when i called the dr., he said that is normal when switching dosages and will go away."