"i have been on every ssri out there and they do nothing for me. i was on remeron about 5 years ago and noticed a significant lift in my depression and felt as i did before i suffered from depression. it also allowed me to get the sleep i struggle so hard to get every night. after a layoff with no insurance i came off remeron. i recently have suffered from major depressive disorder and was put on what was supposed to be the best of the best lexapro. after a year i still saw no difference except for the lack of sex and asked my psychiatrist to switch me to remeron. he was surprised but did so with no objection and i&#039;m currently tapering off the lexapro and only two weeks into it i am beginning to feel much better already."