"i have synovitis/tenosynovitis , which is a severe, rare bacterial infection in my hand.  i had three operations, almost lost my hand, and it was gutted like a perch. because of the types of antibiotics i had and still have to take  no opioids  worked at all. oxy, norco, percacet nothing. finally my pain doc came upon nucynta. i started out taking four 100mg fast acting and 400mg of the er. i&#039;m now, after almost a year, down to 200mg er and 225 mg of fast acting. i can&#039;t say the er does anything at all but the regular was a home run. it&#039;s a weird high, can be hard to walk and talk, but stay in one place and be quiet. it really helps with the pain."