"i had been using a prescribed topic gel (bianca) for 5 months when i reached out to my doctor to pair it with a medicine after reading reviews that pairing oral and topic medications can work wonders on skin. i was given doxycycline, and can honestly say this combination gave me 85% clear skin, which i was more than happy with. however, doxycycline lowers the bacteria level in your body which causes less acne. but it also threw my ph balance off and i got frequent yeast infections that were unresponsive to treatments. so i had to ditch the doxycycline, still using bianca religiously, and almost immediately, the infections cleared up. but my skin has gotten pretty bad again these past few months :&#039;("