"i started taking trinessa about three months ago as a primary birth control while i am on isotretinoin (accutane).  overall, i have had a positive experience with it; i haven&#039;t had any nausea, headaches, abnormal mood swings, or acne flares.  the main negative thing i have to say is when my first period started while taking this i had the worst cramps ever, and a pretty heavy flow.  however, my second period rolled around, and i did not have any cramps at all plus a normal flow!  the only other side effects i have experienced are hair loss and some breast tenderness."