"i took regular seroquel which did help somewhat. i would rate that at a 4 out 10. i found about seroquel xr when people told me to see a pdoc this was in 2007 because i was bipolar 1 and couldn&#039;t get it under control on my first visit with pdoc i told her my situation and seroquel after my visit she gave me 2 samples of seroquel xr which was only out 4 months at that time it has been a huge help with mania and depression i take 800mgs at bedtime when i wake up i take 400mg lamictal that helps a great deal for me with the racing thoughts and impulsivity along with 2mg of clonazepam that has been a life saver it took many years in and out the psyc hospitals to finally get it right."