"everyone responds differently to medications, and no two people are alike - so i kind of find these forums as being useless (if not borderline ridiculous). but just to share my experience...i have mdd (treatment resistant) along with complex ptsd. i have tried every medication under the sun (over 90 different meds) before finally being introduced to parnate in march of 2016. i was initially started at 10mg and eventually moved up to 60mg within 3-4 months. it seemed to be somewhat helpful for my depressive symptoms yet it created so many other horrific side effects along with it, that life is now worse than ever. never have i been on a med with so many unwanted side effects. i&#039;d rather be severely depressed any day of the week."