"i have been on ssri since the age of 14 now i can tell you i am 42 now and have lived half my life in a fog. feeling tierd, not interested in anything just wanting to sleep. i changed from lexapro to cymbalta a week ago and wow.  i have energy i&#039;m not like dragging myself around all day. i feel motivated - the only down fall has been hot flashes. i read cymbalta can cause that but i will deal with it as i feel as great. i have more than one emotion, i would say definately try it everyone is going to respond differently. have had some issues waking up alot at night. but that&#039;s about it. i have to pay 200 dollars a month for this medicine but it is worth it. good luck to you"