"i have been on contrave for 5 days. i told my doctor that i could not take anything that would make me tired during the day or give me insomnia. score!  i do have chronic headaches and currently take no meds.  my doctor gave me the first starter bottle free because she wanted to make sure i could tolerate it before investing.  i am currently taking one pill per day.  two hours after i take it, it&#039;s like a &quot;one-glass-of-wine&quot; feeling.  i&#039;m less stressed and have absolutely no appetite.  some foods that i generally like don&#039;t even taste good.  i&#039;m hoping the meds will continue to be successful.  my mouth is a bit dry, but nothing significant.  i also have headaches, but that&#039;s typical.  i&#039;ve already lost weight and no fatigue!"