"i have been taking this medication for many years. the key is that it has to be paced. if you take it too frequently, it becomes worthless because you build up a tolerance for it.  you can become moody and agitated. finding a lifestyle change  and not relying on a drug to stay thin. i take it very intermittently, by that i mean every 3 weeks to every month and a half as needed. i save it for my temptation days when i&#039;m gonna need it the most. my weight has not changed from the  75 lbs. i originally lost 10 years ago."