"after having a serious injury to my back from a work related accident,and dealing with surgeons/physiotherapists and an array of specialist, i was diagnosed with major depression and adjustment disorder. i have tried a multitude of anti-depressants to no avail. finally my doctor said that there was a fairly new medication, pristiq that many people in similar situations were having success with and little side effects [as opposed to the traditionally prescribed medicines for similar situations]. i was very close to suicide because my whole normal life prior to my injury was gone. so what did i have to lose, i tried it. what a difference it made within the first week! i still can&#039;t do the things i used to do, but i can actually focus on things i can."