"male, 6&#039;2&quot;, 150lb. i take 75mg of effexor xr in the am and 15mg of remeron in the pm for suicidal depression and generalized anxiety. some days i take higher doses of 112.5mg and 30mg. the combination has worked wonders for my condition. i started on remeron initially and titrated to 45mg/day, but did not feel it was working for my depression, although it did help with sleep and appetite. i tried gabapentin for a while and was able to quit remeron entirely for some time (wanted to give my receptors a break). gabapentin was great for anxiety but made me more suicidal. i quit gabapentin and went back on just 15mg of remeron, this time also adding the effexor. i have been very happy with the results. it seems to be the first medication that really works for me. i had significant side effects when starting effexor, but they subsided completely after about a week- feeling high much like mdma, and i had diarrhea and some insomnia. when i increased from 37.5 to 75 mg, the only con i noticed was lower energy level (and some yawning). i started drinking some coffee to help with that. this is a very serious medication to be taking, as i know it can be very hard to withdraw from; however, i am committed to sticking with it. eventually may increase my dose up to 150mg. effexor makes me feel very mellow. i am less concerned about what people think of me. i am quite confident with the ladies. my sex life has been better than ever on this med combination. i have wondered if my sense of humor is dulled, however. i am also somewhat lazy, but this may change when i go up to a higher dose. risk-taking behaviors should be watched when increasing the dose, as i broke my ankle playing sports. overall, i give this medication 9/10 and am very happy that i got the script. i recommend taking it with remeron to better manage the nighttime, and to counteract the side effects. they have a wonderful synergy. my only concern is that they may eventually stop working, and i may eventually have to stop taking them and suffer the infamous withdrawals."