"i was on percocet 10 / 325 mg for about 10 years, and i asked to switch first to a bupephrine patch, which i was too terribly allergic to and had awful withdrawal symptoms from, and then i asked to switch to hysingla because i felt like a pill junkie and disliked the high/low cycle. plus, i was starting to cheat and take two each morning of my 4 per day allotment.  with hysingla, i had to endure titration to get the right med strength so started out with 10 mg for two weeks. i barely felt relief. then moved up to 20 mg for two weeks but didn&#039;t feel too much difference from 10mg. then tried 30 mg for two weeks and i could tell it was working but not well enough, so now moving to 40 mg. hopefully this will be the trick."