"i have been on zoloft, lexapro and effexor. effexor has been the one that worked for me, the other two were nightmares. i took effexor during a particular bad time after high school and it saved my life. i had wanted to die back then. just recently these past couple years i&#039;ve noticed my depression creeping back and the death of a family member has added some anxiety in there as well. i told my doctor i needed something or i was gonna spiral downward. i am taking the lowest dosage 37.5 mg i believe. it&#039;s been two weeks and i&#039;ve had some expected side effects. nausea, constipation, trouble sleeping, and a little bit of dizziness. nothing terrible. within three or four days i noticed a change. it&#039;s worked for me and i&#039;m glad i&#039;m back on it."