"i was tried on this for major depression. after 2 weeks on 50mg per night, i couldn&#039;t handle it any more. i ended up going to the er because my heart was racing. i was at 125/130 beats per min. i&#039;d only been getting a few hours of sleep each night in those 2 weeks, and experienced the heart racing, brain short circuits, insomnia, anxiety, severe constipation, extreme thirst, and an overall feeling of disconnect from aliveness. 



as a teenager, i took doxepin and elavil too, and they were slightly better, but not much. these tcas should be a last resort like thorazine and lithium. seroquel is much better. good luck to my fellow sufferers!"