"i have been on quite a few antidepressants in addition to xanax.  the antidepressants made my anxiety and panic worse, needing to increase my intake of xanax when on the antidepressant(s).  i was really reluctant to take the xanax when i was first prescribed the medication.  i have been of pristiq for 8 months now and have lowered my xanax from 1 mg in the morning, 1mg midday and 2 mg at bed.  i am now taking 0.5mg in the morning and 1.5 mg at bed.  i am taking vitamins, doing yoga and taking better care of myself. my doctor knows, i am honest. he wanted me to take 2mg every 8 hours but never did. my mother just died a few weeks ago and have been getting really bad anxiety and still the same dose helps me.  hope this helps."