"i have been taking 450 mg of bupropion and 20 mg escitalopram for about 3 years and the combination has been working pretty well to control my depression and anxiety. i had breakthrough depression a couple of times a week, when i would feel guilty about random things, worry about things i couldn&#039;t control and get pretty &quot;weepy&quot;. my doctor prescribed abilify, starting at 2.5 mg and increased it to 5 mg. this helped a lot! however, i  gained 25 pounds in 3 months. i am tapering off abilify, and will start 25 mg of lamictal tomorrow."