"i too, had tried all the tricyclic&#039;s, ssri&#039;s and snri&#039;s along with helper drugs for anxiety and insomnia. i went on parnate 4 years ago and it&#039;s the only drug that has consistently worked at keeping my depression in check. after a depressive episode that almost killed me, the decision was made to try it. there is no &quot;poop out&quot;. the maoi diet everyone one freaks out over is not that bad - just be mindful of what you eat. following instructions for safe use of this drug is nothing compared to the relief of clinical depression!"