"i did one cycle of the depo shot, and at first, i wasn&#039;t suffering any side effects. i felt fine and really it was so much easier than taking a pill every day. naturally, on ortho-cyclen, i forgot all the time. so the shot was refreshing and just plain easy to be on in that aspect. after about a week and a half, i started to notice an increased appetite. i&#039;m talking, i was hungry all the time. also, i experienced severe acne. i went from having a break out maybe, once a month, to my face being covered in acne. i didn&#039;t experience any weight gain, but i was also doubling my work-out time because of the appetite increase."