"i have been taking spiro for about 5 1/2 months and am only now seeing and experiencing results-- so be patient! i started out on a 25mg dosage twice a day, moved up to 50mg after 3 months and just recently increased to 100mg. do not be discouraged by the initial outbreaks. i pair it with differin, which is a topical cream that helps with scarring but my face has finally started becoming incredibly clear for the first time ever. the side effects that i&#039;ve experienced got more dramatic as i increased the dosage but were never severe enough to quit: irregular period (sometimes twice a month, sometimes not at all, but will regulate itself after a while), shortness of breath when exercising, and i have lost about 6 pounds in the last 2 months."