"i had my first shot of depo 5 weeks after i had my second baby. i am breastfeeding so my options were the depo shot or the progesterone only pill (which the dr said is not as effective). at the time of my first shot i was cleared to workout so i immediately went back to my workout routine. 4 months after my first baby i was 10 lbs under pre-baby weight and by the time she was 6 months old i had gained some muscle back and looked and felt like myself again. i weighed 175 lbs at my first shot of depo when my baby was 5 weeks old and i&#039;m now 170 and she is 5 months old. i didn&#039;t gain weight, but it basically stopped my weight loss. if you are at all concerned about weight loss do not take this drug!! i just want it out of my system for good."