"this medicine saved my life. i have now been on it for 12 years for anxiety and depression. i tried a whole slew of ssri&#039;s over a three year period with minimal success prior to clomipramine. a week after starting clomipramine i started to feel better but had some major side effects (dry mouth, constipation and later weight gain). with the ssri&#039;s i had no or minimal side effects. i thought maybe these side effects mean the medicine is working. the side effects continued for about 5-6 weeks but damn i started to feel like my old self. i gained about 15 pounds in the first 8 months but i didn&#039;t really care because i could live again and enjoy my family and friends. the weight all came off after about a year with exercise and eating right. awesome!"