"i&#039;ve been on this medication for just over 2 months now, taking 40mg a day. when i started on a low dose, the first 3 weeks i experienced severe dry skin, lips, and especially my nose and under my eyes even. the first 5 weeks my skin broke out worse. and from the beginning i started getting severe back pain. now in week 9, my skin has settled down and is a tiny bit better, but all my blackheads have disappeared. my skin is still drier than usual, but it&#039;s actually improved, and my lips are fine as long as i apply vaseline 2-3 times a day. the only significant side effect i still have is my back and bone/joint pain. so far i&#039;m very happy with what i&#039;ve achieved (the blackheads) and expect things to keep improving."