"i have bipolar1 disorder with history of psychotic features. i have just started taking 40 mg of latuda per day, as i am being weened from 900 mg of lithium.  i was having so many adverse side effects, such as tremors, extreme dry mouth, weight gain and thyroid issues.  additionally, it didn&#039;t seem to be working very well.  after a few days, i notice an amazing positive change in my mood, my appetite, and stability.  i am still on 800 mg. of seroquel/day and 150 mg of pristiq, but it all continues to go well, seroquel will be the next to be reduced.  i am very optimistic, and have not felt this way in a long time."