"long story short. i have suffered depression for 20+ years and anxiety for the last year which led me to resign from a stressful management position, my co worker recommended zoloft, my gp started me on 50mg which i took for 2 weeks, my dose was increased to 100mg, it has now been  about 6 weeks, i had very few side affects for a few days, slight insomnia, loss of appetite (have lost quite a few kgs) and a little jaw clenching, i feel a lot calmer, i have a little more interest in activities, showering, cooking and cleaning more which are all great results, family members have noticed subtle changes, laughing/smiling and doing more, in saying that i feel as though my dose needs to be increased but will give it 2 weeks, give it  time:)"