"i did phentermine 37.5mg, 3 yrs ago for 8 months with dedicated exercise.  lost 60lbs-weight to 135. i kept the weight off till 10 months ago when i tore my acl and meniscus, needing surgery. i gained 40 pounds and haven&#039;t been able to loose the weight.  i resumed exercising 4 months ago (walking, biking) and i&#039;ve tried dieting again, but i just couldn&#039;t loose weight this time even with phentermine. the doctor added topiram 50 mg 5 days ago and i&#039;ve lost 7 pounds, appetite gone!  i am really dry, drink tons of water.  episodes of nausea pass after a few deep breaths and positive thoughts.  first couple days were the toughest with feeling sick.  make yourself eat a couple bites of something little every couple of hours.  it&#039;s great!"