"i am a 57 year old breast cancer survivor who has been in excellent shape, trim and happily married. after menopause, i developed insomnia, weight gain and depression.  can no longer take estrogen due to breast cancer, which made me feel tired all the time. thyroid medicine helped but not enough--no energy and lost interest in doing things.  my doctor insisted i try ssris such as lexapro and zoloft, but had bad side effects. i tried many supplements--not much help.   i tried bupropion hcl sr 150 mg.  it worked right away. i take early morning and have energy all day.  i did not have side effects (lost 2 pounds! and insomnia if taken after 10 am).  changed my life! been on it 4 months."