"started taking 50mg sertealine for depression and anxiety, i started getting nausea after the first day, after a week it settled and after 2 weeks i felt a slight change in my mood but it seemed to be more effective for my anxiety. after 3 weeks i started getting some terrible side effects such as a bad stomach and diareha also long painful headaches. anyway a month down the line i feel a lot better i can honestly say the medication is working although it has it&#039;s ups and downs try to stick with it, i would recommend seeing your doctor to get the medication changed or the dosage changed if it has no effect because it&#039;s what i did. my quality of life has become so much better. i try to ignore the occasional side effects! stick with it"