"i have tried pretty much all antidepressants under the sun and having been taking antidepressants since i was 15 years old. prozac worked for me for about 2 years then after going up to the highest dosage, it lost its effect. all other antidepressants i have taken have had multiple negative side effects. pristiq is the only antidepressant i have taken that has had no negative side effects and doesn&#039;t interact with any of my other medications. pristiq has literally been a lifesaver for me."