"i started taking spironolactone 3 weeks ago (50 mg 2/day, so 100 mg dose) and my acne is the worst it has ever been. i get cystic acne on my chin but the rest of my face is usually okay. as of last week i broke out in so many cystic pimples on my chin, along my jawline, on my cheeks, even some by my nose. my acne hasn&#039;t been this bad in a while. from everything i&#039;ve read about this medicine, it seems i am in the initial breakout period that only some people experience. this is very difficult to deal with but i am going to wait it out for at least 6 months. also, my period is always irregular, sometimes i don&#039;t get it for 9 months. but since taking this medicine i have already had my period twice. "