"full knee replacement used hydrocodon/acetaminophen for initial 15- days then dr prescribed tramadol for pain during physical therapy. first one i took i couldn&#039;t sleep and wide awake to 4:30am!!  ok, maybe something else causing it? i read side-affects not many comments. i got by on ibrophen during next few days didn&#039;t take tramadol for 2-days. 
3-rd day by 6:00pm after working 8 hrs at desk job then on to 1-hr pt got home and decided to try tramadol again. i took one 50-mg at 5:30pm and didn&#039;t sleep until 3:30am!!!  i also experienced itchy hand palms i noticed and lasted about an hour.  my pain isn&#039;t getting relieved either!!  
can&#039;t continue, need rest, stopped taking and just using ibrophen until i see dr tomorrow!!"