"i am currently taking 1/4 of a 5 mg tablet (but started out on a 1/2 tablet) of saphris at night.  i am also on lexapro, 10 mg for depression and anxiety.  the combo works great.  i have horrible insomnia/waking in the night on just lexapro (or other ssri&#039;s i&#039;ve tried) but with saphris i sleep great and wake up refreshed!  only downside is that i&#039;ve put on 10-15 pounds in the last 6 months, but not sure if it is due to the lexapro or saphris or both.  i eat very healthy (just too much) and exercise regularly....but find myself always feeling hungry.  oh well...at least i&#039;m happy!"