"i was diagnosed with bi-polar disorder 18 months ago and put on lithium 600mgs a day and seroquel 300mg at night.  the lithium has been wonderful to stabilize my moods and keep me from feeling so down and depressed. i eventually weaned myself from the seroquel because it made me lethargic and i had weight gain that i contributed to it not the lithium.  i now exercise - run 3 miles a day to help me release any pent up anger or negative energy and it works wonders.  lithium maybe one of the oldest bi-polar medicines but it is tried and true."