"i started taking spironolactone about 3 months ago on 25mg. i noticed a change right away but then my skin went back to usual after a few weeks. i then upped up my dosage to 50mg 1.5 months ago and noticed a difference again right away. my skin was almost 100% clear. about a week ago my skin started getting bad again. thinking i might start doing 25mg in the mornings, and 50mg at night. hopefully this will be what works for me! i&#039;m not giving up!"