"i love spironolactone (i take 200mgs a day). i am 46 years old and started with cystic acne at 21 and tried everything: roaccutane (hideous side effects - an evil drug), dianette (severe nausea all the time), retin a (great but burned my skin), oral antibiotics (caused severe and permanent hyperpigmentation).  so as you can see spironolactone is a breeze compared to the others i&#039;ve tried.  i have gained a few pounds and have breakthrough spotting but i do not have a single spot (as long as i wash my make up off!).  it&#039;s been about 4 years and i dread the day my gp tries to stop them (i am in uk)"