"started orlistat as well as metformin two days ago. i have no health problems, i just have struggeled with weight forever. so far i&#039;ve lost 4 lbs in the 2 days of taking both medications. really hoping this continues. i am on a low cal/low fat diet and yes, i do have very soft stool and i do have bright orange oil when i do pass stool but no accidents so far. it&#039;s really not bad at all and for me its a sign that it&#039;s working! the pros far outweigh the cons if you have been overweight your whole life. my highest weight was 290 last year and so far i&#039;m at 257. my goal weight is 170."