"i take 100mgs of seroquel at bedtime (for almost a year now) and i have started to build a tolerance to it so it takes about a hour or two until i start feeling tired but once i am alseep..i am sound asleep!! i have read many post about the weight gain. i have gained about 30lbs since i&#039;ve started taking seroquel. i spoke to my doctor about it and he is now switching me to chloral hydrate 500mgs only due to my weight gain and concern. i hope the new medication works just as good. hopefully i can shake off this weight and get a good nights rest but over all, i would recommend seroquel to anyone dealing with insomnia. i am definitely not throwing the rest of my seroquel script out just in case this new medicine is a flop. good luck to all."