"i have been on remeron for 3 years now and it&#039;s the best antidepressant i&#039;ve ever been on. i have tried prozac, celexa, wellbutrin, and effexor. remeron is the only one that made me happy to be alive. i did gain about 3 pounds but then was feeling so good i decided to become a vegan and improve my physical health, which before i could have cared less about. so now i&#039;ve lost the pounds. plus, a few pounds is definitely worth the improvement in mood and sleep. i have found it&#039;s really important how much i take and at what time. i did get restless leg syndrome which made it hard to sleep so i tried breaking up my 30 mg pill and taking 1/2 at 7:30 and 1/2 at 9:00 pm. that wasn&#039;t helping my mood/for best results, i take 30 mg at 6:00 pm and go to bed at 9:00."