"i have been wanting to write this for a few months because i have seen so many questions about side effects/interactions.  i started taking sr on a friday, i was fine, saturday - fine, sunday - fine, on monday i went to work, by lunch, all he** broke loose, the dreaded diarrhea. all day monday was horrible, tuesday, same thing, by wednesday i could not take it anymore, so i started researching and found that wellbutrin (budeprion)  interacts with caffeine. so wednesday- no coffee,  no diarrhea, thursday- no coffee, no diarrhea.  so i have only drank decaf coffee since, and have had no diarrhea."