"the only problem i have had with vicodin is that it really upsets my stomach. whether i have an empty stomach, full stomach or whether i eat right after i take it or right before. it doesn&#039;t matter. still makes me so sick. so my doctor suggested that i crush it and add it to yogurt or something of that sort and it has been helping a lot. i don&#039;t know what the difference is but hey, it works and i&#039;m pain free."