"i sure hope me writing this can help someone avoid the prolonged agony i experienced on trintellix. i started with a 5 mg dose for one month. after about 5 days, i started having itching on my external vulva.  by the 7th day, i almost went to the er, but by that time, due to all my scratching, i had developed a pseudomonas aeruginos infection. four courses of antibiotics later, the unbearable, constant, relentless, and ever-present itching was still there, with some hives. though the infection was gone, the itching continued. i have never had intense itching like this--the more i scratched, the more i itched, and i couldn&#039;t even sleep. two days after stopping trintillix, the itching was gone. two months of hell. fixed drug eruption."