"i switched from zoloft due to fogginess at higher doses.  as others have mentioned, the nausea and dizziness were definitely difficult for me when i first started brintellix.  at the same time,  i could tell this was working for my depression.  i was so grateful for the antidepressant effects.  i cut back from 10 mg. to 5 m.g. (half a pill) for a couple of weeks and the nausea began to subside.  i went back up to 10 mg. and now nausea is only an occasional problem.  my doc said to make sure to take it with food, which i do in the morning.  i know others take it at night.  the nausea was indeed difficult, but i am so glad i stuck with it.  for me, it is a very effective antidepressant."