"bupropion, the generic version, makes me feel more on top of things. i do feel the medicine kick in after about an hour and i get a bit &quot;high&quot; if you will. it&#039;s a feeling of motivation to go do things and be productive. the first time i was on wellbutrin (one month), it only lasted about 2 hours (at least what i could feel) and ended up not caring about anything for the rest of the day. then recently i started wellbutrin xl 150mg and it lasts much longer. i made the mistake of taking it at night, when i should have taken in the morning. bad insomnia because of it, but i learned my lesson. i&#039;d say it is the only antidepressant that has worked on both depression and adhd by helping me concentrate, remember, stay on track, and also motivation."