"i have had major depression my whole life and absolutely none of the anti depressants worked for me, i had intermitant periods in my life were i had suicidal thoughts but i always managed to tough it out i maintained decent employment but chronically underachieved because i was always fighting internal demons and social anxiety, then my children left home, i got a divorce and lost my home, suicidal thoughts were non stop no matter how hard i tried to talk myself into coping and turning my mood around, the suicidal thoughts persisted for 2 yrs, then i was prescribed tramadol for fibro 50 mg twice a day, i have never felt so normal in my whole life took it 3 yrs no dose increase off it for six months too hard to get the rx now suicidal 24/7"