"i started trintellix/brintellix 9 months ago and it worked good for depression except i was recalling memories from the past which were disturbing, and i seemed more sensitive to negative issues in the world.   this felt odd and disturbing but i stayed on it.  i had no weight gain but in the beginning i had severe esophagus pain and ear pain which came and went for months... oh ya, i also threw up the first few weeks. this drug made me hyper for months and then a month ago , i crashed and went into a depression.. well, i think it&#039;s time to go back on cymbalta.  i gave trintellix/brintellix a good try.  strange drug.  hope the withdrawal isn&#039;t too severe."