"started post-break-up. happy now, don&#039;t credit meds, but still take wb &amp; never want to stop (unlike clonaz. &amp; desipr.) bc other reasons to take. lost weight, gained energy, desire to be social. now only anxiety and ibs; the wb counters some sexual side effects of other meds. not a morning person, but 450 sr(12hr) right b4 sleep (right b4 or insomnia)=hop out of bed at alarm. if i take 450 in morning, easy to resist food. wish i could have both, but splitting dosage or taking xl(24hr) doesn&#039;t work. 167lbs 6yrs ago @start, down to125. 3yrs of 130lbs but built-up tolerance, so then 150lbs 2yrs ago. took @night for months, then back to morning &amp; now 1yr 135lbs. 450mg is max. new dr: split time night &amp; mrng. but that would defeat 1/2 its purpose"