"the nexplanon is effective in preventing pregnancy. however, i experienced two pretty severe side effects while using it. a week after insertion i developed terrible acne, then about two months in experienced depression. i do not have a history of depression or a family history of this. it came out of no where very quickly and was really quite bad, the worst of it lasting a week or so then slowly fading away. i felt right away that it was likely the nexplanon. i had it removed and my symptoms ceased and have not had a reoccurrence of depression or the acne since having it removed."