"this is a great add-on medication for depression. i am compound heterozygous for the c677t and a1298c mthfr mutations. i was taking celexa and wellbutrin and still having frequent depressive episodes when i first started taking the deplin. after about a month on deplin, i weaned off the wellbutrin. we later lowered my dosage of celexa too. i did try to wean off celexa completely and use deplin as mono-therapy, but ran into issues.



i&#039;ve been taking celexa 20mg and deplin 15mg for over a year now and it&#039;s still working great!"