"i tried just about everything for depression and venlafaxine was one of the only drugs to help. i was so depressed that i jumped off a building for a suicide attempt. i wound up paralyzed in a wheelchair. venlafaxine took a while to work about 3 moths or so. i first took 75mg but didn&#039;t do much. it wasn&#039;t until i reached 375mg that i felt the true effects of the drug. very very strong antidepressant effects. my mind is clear and i&#039;m feeling a warm glow all day. my depression so anxiety are gone even though i&#039;m paraplegic i am happy. wish they gave this drug to me a long time ago i would not be in a wheelchair. you have to really be patient and find the right dose abs then one day you&#039;ll wake up and feel great."