"have been on and off saphris several times. for me, being on saphris is like turning a light switch on. i go from being manic/depressed to functioning like a normal human. but.... the side effects have made me quit several times - irregular heartbeat, fainting, nausea, etc. now back on at a low dose with lamictal and clonezepam for panic disorder. feel pretty good. hope it will last. without saphris, i am non-functional - so doing my best to manage the side effects while getting the benefits of this medication. best of luck to all."