"i really noticed a negative difference when comparing the xr version to the regular seroquel.  it took longer to kick in and made me so drowsy at work that i felt like i was drunk.  i think i was taking 100-200 mg.  when i went back to regular seroquel, 100-200 mg put me to sleep fast and made a difference in stabilizing my mood without me feeling too drowsy to function the next day."