"have taken parnate for 5 years. tried 5-10 other medications before trying parnate. had bad reaction to most of these - worsening depression and anxiety.currently taking 80 mgs of parnate, which is above the normal therapeutic range. have a few side effects that still come and go including daytime fatigue/some tachycardia right after dosing. take 30 mg in the morning, 20mg in the afternoon, and 30mg in the evening. when started taking it had pretty bad orthostatic hypotension for a week or two. medicine works well. depression and anxiety have been kept at bay for 5 years. i can enjoy life. highly recommended"