"very effective. i have osteoarthritis and can be pain free with codeine. it is more effective with ibuprofen.  also
profoundly lifts depression due to chronic pain and makes such a better life day to day. space doses well apart to avoid tolerance. i use only in the morning with very good effect. using whole daily dose in the morning may get you through the day without a need for a second dose. i would leave at least 6 hours between doses to assure full effect.

don&#039;t suffer needlessly. good luck and hope this helps."