"i have tried numerous psych meds over several years. i could not take any of them due to side effects. been on vortioxetine about 7 mos. it has improved my depression and helped me feel good and confident.  at first the side effects were some nausea, itchiness and diminished vision. the benefits outweighed the side effects-especially since-unlike regular ssris-this med does not interfere with my ability to think clearly and complete my work. now though i have developed joint pain and muscle stiffness. also maybe it shrinks my tendons. when i skip med for a day pain/stiffness reduces and vision improves. (nausea and itchiness had already become a non-issue). hope next generation med fixes vision &amp; stiffness pain problem. will talk to doc soon"