"i started adipex 5/1/12 at 354 pounds. i have no metabolism but my thyroid levels are normal so no amount of exercise worked for me.  it would keep me from gaining but couldn&#039;t lose any.  in two months i&#039;m down to 344 but i can tell it is starting to not work as well.  i think i&#039;m about to stop weekends so my body doesn&#039;t get used to it so much.  i&#039;m hoping to get back to around 200 where i was in high school and very fit."