"i&#039;ve been using tri sprintec for almost a year. i&#039;m not sexually active, but was prescribed it for month-long pms, spotting and irregular periods. by irregular i mean 27 days one month, 30 days the next month, 25 the next, and so on. i have 28 days all the time now, occasionally 27. pms is much better, skin cleared, and i&#039;m much more emotionally stable! i do notice pms in the last week, but that&#039;s to be expected as there&#039;s no hormones that week. the other thing i have noticed is that it does dry out my skin, eyes, scalp and vaginal  area. i believe that&#039;s due to the same stuff that keeps your skin clear. i did notice a bit of nausea in the beginning, but that should go away. it helps to take it at night. all in all, great pill!"