"i have had dysthymia and bouts of moderate and severe depression throughout my adulthood. i tried different ssris but always doubted their effectiveness. after my third bout with severe depression two years ago, i was finally prescribed bupropion, and from the get-go it made a difference. it boosts my mood and energy levels. the first year i was on it, it suppressed my appetite which resulted in effortless weight loss. almost two years later, i am still on it, and the weight is back (typical middle age tummy.) i experience minor hand tremors daily. also, it appears i have sad. i seem to do okay on 150 mg in during spring/summer but need 300mg in the fall/winter."