"i have taken trintellix for about 6 months after trying absolutely everything else.  at first i was thrilled at how much better i felt.  i could concentrate again, was sleeping for the first time in over a decade, and felt more motivated.  however, for the past few months, i have been feeling moderately to severely depressed, so much fatigue that all i want to do is sleep, and itching and muscle pain.  most disturbing though is how little i feel like myself.  anger, mood swings and feeling irritable are affecting my relationships and my desire to help myself.  time to discuss discontinuing this med with my doctor."