"i&#039;ve been on pristiq for 10 days now. it has really helped me -no side effects. i eat when taking it, it helps. i&#039;m also on suboxone for pain. i&#039;ve noticed that i smoke more now, which might be from financial problems. i get constipation bit more but minimal problem. i have to take it in the morning like many people say or it keeps me up. weird how different it affects people - some people say it helps them sleep. goodluck folks."