"having tried several different acne medications, and what seems like hundreds acne creams by brands like clinique, kiehls, neals yard, mario bedescu and clean &amp; clear, my dermatologist prescribed me epiduo. the &#039;purge&#039; phase was awful, my skin got a lot worst before it started getting better, so bare that in mind when starting the cream. i am so thankful for this cream, it completely cleared my acne within one month! however, the side effects can be quite painful and frustrating, still after sixth months i experience extremely dry skin and occasional burning of the skin. these side effects haven&#039;t gone away for me as i continue using it. just bare in mind that at the expense of curing your acne, you will experience side effects long term."