"i have been taking 10mg since nov.5 2009. i have gone from 203 - 177. i went off for two weeks this past month and i have not gained but have stayed the same. during my time off however i had times of high anxiety and irritability, especially, when starting the medication again. my blood pressure and pulse rate have been fine. i have had some constipation problems.i think my dr. will raise my dose to 15mg at my next appointment.  my goal weight is 150. i feel so much better. it has helped with mild depression as well. good luck."