"had extreme anxiety after trying champix to quit smoking. i was on this for about a year and a half and then weaned off slowly.  things went downhill at work and i&#039;m just restarting after i felt my anxiety creeping back in. this time though the doc wants me to take it twice a day instead of once a day. currently on two 37.5 in the morning and then another 37.5 about 5pm. i can feel my anxiety lessening after only a week.  just started a new job. my anxiety makes me think my teeth are going to hurt and that&#039;s all i end up focusing on. all day every day. effexor has been a real life saver."