"i was previously on 45mg, it worked for about a week then it stopped working, i was as depressed as i&#039;ve ever been. i&#039;m currently on 15th alongside venlafaxine 300mg, and the 2 medications together work wonders for my depression. so i&#039;d recommend mirtazapine alongside another medication. it helps me sleep well. unfortunately i&#039;ve put on a lot of weight with it."