"i was on zoloft for 8 years.  most of those on a minimum maintenance dose.  in the last few years it affected my memory and it didn&#039;t work as well for the depression and anxiety.  does a good job treating pms.  i had to go off eventually, but it was a good run.  had night sweats and some sexual side effects.  i also would feel nauseous if i was hungry while i was on it.  best to take at night."