"as others have described i have seen a huge change after the first 2 doses.  recent emotional and mental stress along with going through menopausal changes threw me completely off balance. my doctor prescribed pristiq and i cannot believe the huge change. my head is so clear and balanced, i feel like the slate has been wiped clean. my eyesight also feels clear.  i suppose that is because my brain is in better balance.  i believe this to be a wonderful improvement on this type of anti-depressant and i will continue to take it for as long it helps.  the only side effect i have is slight nausea which should subside in a week."