"i started taking bupropion 1 1/2 years ago.  at first i thought i had found the best meds for my condition but about 8 months in, i stopped feeling the effects and starts having anxiety attacks almost daily.  my doctor upped my dosage from 100mg to 200mg.  fast forward to present day and i completely went crazy (irrational, irritability, memory loss, loss of sex drive, and so many more things that i am embarrassed to even say even though this is anonymous! my wife and i looked up some of the side effects of this drug (after long term use) and saw that i was displaying just about all of them. i have since began to taper myself off the drug and for the past week, while my anxiety is still there, the other &quot;issue&quot; i was having are gone."