"i am presently in hospital and have been put on seroquel xr.  as previously commented, the low dosages cause lethargy and sleepiness.  however, i am not nearly as suicidal as i was, i have hope for the future and have not been on for more than a few days.  i am optimistic that once i have reached the proper dosage that i will once again enjoy life as i once did.  paxil, effexor and a number of other antidepressants worsened by symptoms over time and/or never did do much for the depressive symptoms in the first place.  this medicine is worth trying if you are extremely depressed or suicidal."