"i have moderately severe acne.  i&#039;ve tried all topicals and nothing has worked for me. i finally went to a dermatologist march of 2015, 90 days of doxy 100mg as well as differin cream. i noticed a huge difference fairly quick. at the end of i would say 30 days my skin was totally clear, minus my scaring! i continued to take the rest of my prescription. this antibiotic doesn&#039;t have permanent results. i was 100% clear for 7 months, it slowly came back around month 6 and now i am starting a new cycle of the same thing. the side effects were zero for me, i&#039;ve heard accutane (where the results are a lot more permanent) has made some people suicidal so i have no objections to doing this once a year!"