"buproprion xl was helpful for a season when depression was hitting very hard with bipolar.  when i initially started taking it, i saw effects right away.  i didn&#039;t notice any false happiness like many associate with &quot;anti-depressants&quot; but it lightened my mood which had been pretty depressed for some time.  over time i did notice the effect of the drug lessened and i did quit taking it, but it was helpful during the time i needed it.  i had previously tried zoloft and i found buproprion superior to zoloft in my personal experience."