"i was on effexor xr for almost 4 months for major depression and anxiety. it caused stomach upset which got worse with every increase in dosage.( i also suffer with ibs so it was hard to tell for a while if it was the effexor or not.)the worst part however, was yet to come. i started spotting the 3rd month i was on it and by the 4th month on 150mg, i was bleeding as if i had my period every single day. my psychiatrist is tapering me off it and at 75mg now, i have less stomach pain and no bleeding. we will try zoloft next."