"i was on low dose cymbalta for 2 weeks and could not handle the fatigue. i switched to pristiq 50 mg a little over a week ago. my anxiety is 95% gone, my depression..the negative thoughts are gone, i&#039;m not happy but i&#039;m not sad either, my irritability and being easily startled has resolved. i&#039;m able to go out without being anxious, am  returning to work part time in a few weeks. i do feel a little tired a few hours after taking the medication but it doesn&#039;t last, my sleep is a little disrupted, little nausea but nothing i can&#039;t manage, constipation is a side effect but i use colace (without the laxative), lost 4 lbs so far. plan to stay on this indefinitely at this point. just relieved to finally have some relief from the anxiety/depression."