"i&#039;m on the second week and i do not feel as sad and anxious. upset stomach for a couple of days but is wasn&#039;t too bad. i was diagnosed with being homozygous for the 1298c mthfr mutation. anyone dealing with depression should be tested. the problem with having this mutation is you have a problem with methylation so you can&#039;t make enough dopamine and seratonin.  also you have a problem with norepinephrine and which causes anxiety.  defects on the 677 /mthfr gene can cause bipolar and schizophrenia.   to help with methylation need to take methyl b12 and folate (not folic acid)... people with these defects can&#039;t process folic acid. that is why dr.&#039;s add deplin to prescribed medicines.  "