"i was on depo for over seven years. i never had any bad side effects and it helped tremendously with my horrible moods. i had extremely irregular periods (i would be off my period for less than a week each month) and after two shots i quit having one completely. i have had no spotting either. i&#039;ve gained about 30 lbs in that time, but getting older and married may have done that. i just recently stopped my shots and it&#039;s been one month since i was supposed to get it. i&#039;ve already noticed i get mad and cranky faster. hopefully just a coincidence."