"compared with the traditional ssris i would say that this is a gentle drug   you can feel the increase in serotonin nevertheless. i have cyp issues so am starting on 2.5. and it&#039;s ok so far. i think it reacts with the quetiapine to increase unwanted sedation. i have had no big s/e and i really feel docs should start this low. none of us take meds for fun. with severe depression mixed with gad i am cautiously optimistic.   it&#039;s expensive so if you&#039;ve bought some and are struggling i seriously advice lowering the dose and i hope you get the benefits in due course. old dodgy"