"i&#039;ve been on deplin for 20 days now, along with zoloft.  i had great success with cymbalta, but it messed badly with my blood pressure (going from 112/65 to 175/100) so i had to go off it.  i was put on zoloft as a stop gap, but have tried it in the past without much success, as with all the others.  they say it can take 4-6 weeks before deplin has its full effect.  i&#039;m still hopeful, but i do so wish i&#039;d seen the overnight change like others. "