"i had severe insomnia for years which caused major major depression and anxiety.  i tried a ton of medications, but seroquel was definitely the best.  i&#039;m still on it at 150mg (3 x 50), which gives me 7.5-9 hours sleep/night.  when i take 100mg, i get about 5.5-6.5 hrs sleep. i take it an hour or so before bed.  it sucked for about a week when i got on it, but i have been on it for 3 years now and it&#039;s a lifesaver.  i still have nights where i have bad sleep, but it&#039;s rare.  i have had 0 side effects.  just as a reference, mirtazipine did work for me too, but i gained weight.  ambien never worked well and benzodiazepines worked, but addiction scared me.  insomnia is the worst and this medicine gave me my life back."