"i was very sceptical about using differin cream as i had done a lot of reading and has obviously read about the dreaded initial breakout! a side note, i am also on lymecycline 408mg (tetracycline is the same) and i&#039;m on lucette bc. when i first started using it i left it on for an hour, to see how my skin reacted, then washed it off. i have been leaving it on overnight now for about a week and a half. yes, i have broken out. any worse than usual? no. in fact the breakouts healed, were less aggressive and red. currently the only side effect i&#039;ve got is the corners of my mouth are a bit sore and dry. my skin is very soft where i use the cream. my advice, start slow! and use it so sparingly!! literally the tiniest bit. i am pleased so far. :)"