"i was on prozac and it wasn&#039;t working anymore. i tried pristiq and for the first couple of weeks i didn&#039;t feel &quot;right&quot;. then, i started feeling much better. i also take a prescribed supplement called deplin because my body doesn&#039;t absorb folic acid- a source of my depression. i don&#039;t know if it&#039;s the deplin, the pristiq or both, but i don&#039;t get depressed anymore. i do get kind of &quot;mean&quot; when i drink coffee with it. my sex drive is loooooow and achieving orgasm is difficult. i also suffer from dry mouth at night. but, i&#039;m here to rate the medication on how well it helped my depression and it helped so very much. it&#039;s expensive, even with insurance."