"i have had noticeable benefits with mood support in the years that i have been on and off of same. it has helped me to be less vulnerable to depression and to better control my anxiety. i took 200 mg each morning for a few years and have now been taking 400 mg each morning for a few months now. i have not had any joint problems, but i partially attribute that to same (as a preventative). i have had no side effects and my only discouraging factor was cost, as it is not covered by insurance and is expensive at many retail outlets. i found it online for a much more affordable rate and have been able to take it consistently now."