"i was prescribed nucynta 100mg while taking cymbalta 60 mg.  absolute mistake!  i have experienced serotonin syndrome at least 3 times in the past year. i initially thought my behaviors were attributed to cymbalta, but i finally took time to actually investigate serotonin syndrome and felt blessed that i had not hurt myself because i was taking both cymbalta and nucynta.  it&#039;s very important to learn the side effects and medication interactions of your medicines.  from reading a few posts about nucynta, i would conclude that a few are already experiencing serotonin syndrome. it&#039;s not to be taken lightly, please do your research.  "