"i have been on pristiq for about 8 weeks now. i feel good and i am not feeling depressed or sad anymore. i did go through some peaks and valleys with pristiq at start up for a good 4 weeks and it wasn&#039;t seeming to help. it seemed as though it was making me feel worse but all of a sudden i had a breakthrough and have felt good since. my advice to people just starting pristiq is to give it time you will have a breakthrough, your body needs time to adjust to it. "