"i have found effexor and therapy to be a fantastic combination. the effexor alone has kept me from feeling like i&#039;m going to climb the walls. i didn&#039;t lose any weight on effexor. i actually gained some (in part due to my own lack of exercise). i weened off for about a year while i was pregnant. withdrawals can be rough but not impossible. my advise is to ween very slowly. i went from 75 mg daily to 37.5 daily. then to 37.5 every other day, then every two days, then every three days, etc. until i was taking it once a week then stopped."