"i&#039;ve been taking zoloft for maybe 2 months now.  i&#039;ve gradually gotten up to 200mg and notice a big change in my mood, after lexapro wasn&#039;t cutting it anymore.  i have severe depression and i notice a big improvement.  so far, not many side effects besides fidgeting, i can&#039;t sit still for the life of me.  i&#039;ve also noticed that if i miss a dose of lexapro, i didn&#039;t feel much different.  if i miss a dose of zoloft, i become horribly agitated.  when i sleep that night, i have horribly vivid nightmares and cold sweats all throughout the night and rarely sleep.  i have also noticed a bit of decreased appetite and energy.  overall, so far i&#039;m very happy with the results and hope i can continue on this path."