"i started latuda (20 mg) about 2 weeks ago and felt improvement almost immediately, like within 24 hours. i was extremely skeptical thinking it was just an anomaly but i have felt good every day since starting it. i am bipolar 1 and was in extreme depression and anxiety before starting it. i do not take it with food and have had no nausea. (as a matter of fact i had had more nausea before starting latuda than after! ) i have been on about 8 other meds and none have worked like this. just 3 weeks ago i could not even sit at the table for a family dinner. i was so depressed and anxious i would leave almost immediately. now i feel happy ( yes happy!) and sociable. at first it made me sleepy but that one side effect has left."