"i started taking cymbalta 6 months ago.  i know that they say this medicine can take about 3 weeks to kick in, however, i felt relief within hours of taking it.  maybe it&#039;s some medical miracle or my body finally got what it needed.  i am a well educated woman who had a rough childhood.  i tried different anti-depressants over the years and never felt anything like this.  i stopped having suicidal thoughts.  the side effects were: loss of appetite and so tired that i had to lay down in the afternoon.  the only other medication i take is birth control.  i discovered the following:  if i take my birth control at night before bed and the 30mg cymbalta in the morning then i&#039;m not tired.  the side effects went away by the 12th week so hang in there!"