"i am a 48 yr old woman diagnosed with depression &amp; chronic fatigue. took pristiq for 4 months. my entire system was taxed! i became very angry, argumentative over-reacting to mostly everything, communicating ineffectively, raging, i never relaxed - insomnia! major increase in pain, muscle spasm, migraines!,involuntary muscle movement, etc.! getting off of it was a nightmare! more than a week of constant 24 hr. sickening withdrawal- vomiting, dizziness, confusion, severe pain muscle spasm migraines depression thoughts that i would never make it through! the only thing that helped was prozac-20mg vicodin-5-300 &amp; tramadol-50mg as needed to break pain cycle!"