"i have been on wellbutrin sr 100 mg 2x/day for 5 months and it has helped me a lot. i have panic disorder, agoraphobia, and major depression. it has drastically improved my ability to go out and do things. my thoughts don&#039;t get stuck on anything that could potentially make me anxious (for the most part). i also take zoloft 100 mg until a month ago 75 mg and a couple of days ago down to 50 mg. i can tell the wellbutrin and zoloft decrease is adjusting. i was reluctant to take it because of the panic but it has actually helped with that. i&#039;m not fully recovered however, as i still fear driving alone and being too far from a support person. i would generally recommend it, although it is a bit expensive without insurance."