"i&#039;m going into my third week on topamax.  for the twelve years previous to this medication, i was treated vigorously for clinical depression.  (clearly, to no avail.) my &#039;mood spikes&#039; as my husband and i lovingly call them are already beginning to subside.  my toes, fingers and nose do tingle, and now that my dose is doubled (third week, time to titrate up), i&#039;m definitely losing my appetite. (i have a few pounds to spare, so i&#039;m not mad about it!) i hope to update this page again in a month or so to let you know how the medication is going then.  after being on every anti-depressant the market has ever seen, it&#039;s a god-send to have finally been pointed in the right direction.  (i&#039;m 30 years old, married with a 2 year old)."