"i have had severe knee pain since i broke my femur about 2 1/2 year ago.  my doctor prescribed tramadol/acetaminophen and it worked really well.  since then i have been prescribed tramadol 100mg, time release 3 times per day. on it&#039;s own tramadol does not work as well for me. clearly the tramacet 3.27 is better for my joint pain."