"start 05/23/13 -234 lbs down to 222 lbs 06/12/13. 1200 calories a day and cardio 4 x a week and light weights.   female, age 46 - insulin resistance-metformin, hypothyroidism -synthroid and rheumatoid arthritis -methotrexate -hoping to get down to 175lbs or lower to get off all this crap...maybe not the rheumatoid arthritis meds. first headache today and a little tired.  trial medicines..blew through those.  expensive medicines but works."