"i&#039;ve been taking bupropion 450 mg/day, for at least five straight years. on two previous occasions, i would take it for a year or so and then refrain when things stayed sunny. obviously they didn&#039;t remain that way, so this time around i&#039;m firmly committed to it. 

i have had a tendency to rapid cycle. when i returned to bupropion the last time, the doctor also put me on lamictal and abilify. last year, under her guidance, i weaned myself off of those. after all these years of dealing with bipolar disorder ii, i am fairly well attuned to know when i might need to return to one or the other. 

i take bupropion, with food, soon after waking as it does interfere with sleep. i&#039;ve had no other bothersome side-effects and no alcohol issues."