"i started 50mg of pristiq only two days ago. my doctor didn&#039;t like the medicine combination that i was on before and they seemed to not be working so well anymore. i was taking cymbalta and celexa. i stopped taking cymbalta and took pristiq and the celexa the first day. i was very afraid of a horrid drop in my mood all day being without my cymbalta. but my mood was great. i stopped taking the celexa and only took the pristiq. it&#039;s crazy i feel good. well aside from the dizzy dumb head feeling. i also get headaches here and there but nothing too terrible. in the past i have tried effexor xr, prozac, lexapro and zoloft for my depression anxiety. i am really impressed with pristiq."