"pleased with this medication. i was diagnosed with bipolar 2 two years ago at age 48. started on lamotrigine (300 mg) and buproprion  xl (150 mg) taken in the morning, which worked well, but didn&#039;t calm the incessant negative and depressing thoughts i was still battling. seroquel was added recently. i take 300 mg at bedtime. great sleep medication! this is the best, most effective medicine i&#039;ve ever used if i need to get to sleep early in order to wake up early in the morning for work. i exercise on my elliptical on average 5 days a week, and haven&#039;t experienced any weight gain since taking seroquel, gratefully. i think weight gain would be less of an issue if more bipolar people committed to exercising on a regular basis."