"i have depression and some anxiety, and have been on zoloft and lexapro on and off for years. i didn&#039;t like the side effects: lowered sexual drive, increased sweating, inability to feel either highs or lows (flat), a general &quot;i don&#039;t care&quot; feeling, trouble concentrating and trouble staying asleep. mirtazapine was great for about a month then quit working. "