"i started on 10mg of lexapro and thought i&#039;d struck gold with how much it improved my quality of life - i was only surviving before on zoloft, but with lexapro i felt alive for the first time in decades. unfortunately, after a couple of years i found the effects started to wear off, so i went up to 20mg. same thing happened again - felt fantastic , but after a couple of years the effects started wearing off again. i tried cymbalta - no good for me, then tried pristiq 50mg, then 100mg then 150mg. no good for me either. i&#039;ve gone back to lexapro again - have worked my way up to 20mg in the last 2 weeks, and am feeling so much better for it. if the effects wear off again i&#039;ll go up to 30mg lexapro. it&#039;s the best one i&#039;ve found for me so far."