"i&#039;ve been taken nucynta 100 mgs twice a day and 50mgs of the ir three times a day. before that i was taking percocet 10/325 4/day and oxycontin 20mgs just at night. the first day of taking nucynta, i had a headache, probably from the norprenephrine. however, today it has been nothing but great. i have a bad back which it helps tremendously (as did the percocet) but i also have severe neuropathy in my calf and right foot. for those, percocet didn&#039;t help too much. as far as pain relief goes, it has been excellent. in fact, for the first time in literally 5 years, i only had to take 2 of the instant release instead of 3 that i&#039;m prescribed. it definitely is a unique opioid though. i think it&#039;s great though!"