"i have suffered from major depression since i was 17, or at least that is when i was diagnosed.  i believe it started when i was 13.  i have been on medication every since and i am now 44.  i came across tramadol because i have fibromyalgia and i use it to lessen my pain.  i take 50 mg in the morning and if my pain is unbearable i will take another 50 mg in the late afternoon.   it doesn&#039;t take all my pain away but i can function since i work full time and go to school too.  the most miraculous part of all of this is that my depression while on this is completely gone.  i have to be careful since i am already on anti-depressants that are a serotonin uptake that i don&#039;t ever over do it, because of serotonin  syndrome.  feel like myself :)"