"i was diagnosed 13 years ago as bipolar. i have been on a total of 14 different medications. after a few months, the effectiveness of the medication would start to wear off. i would tell my doctor and he would up my dosage, then i would become a zombie.  cymbalta so far has been the only medication that i have been on for more that a year and a half.  the only side effects i have noticed and that are starting to subside are; tremors, excessive sweating and night sweats, excessive rambling, minor confusion, and fatigue. they are starting to subside, but the medication has been a god send for me and my family."