"i have been on pristiq 6 months.  it took a few weeks of course (plus coming off the wellbutrin), and there are still rare days when i want to curl into a ball, but they are less and less.  i am doing the things i enjoy again, also doing much better at work, actually would call the mood happy and energetic.  friends and family have told me i seem happy and am doing the best work of my life.  i battle depression, and i know that is lifelong, and i also have horrific life experiences that no drug can banish--so there will still be occasional bad days.  i&#039;m realistic.  but pristiq is the best medication i have tried--a blessing. each person is different: if it doesn&#039;t work for some, it works for many others."