"i have taken sertraline for some 15 years now for depression caused by hysterectomy...had never had depression prior to this surgery.  at any rate i began at 50mg and never had any difficulties with this medication and i am very sensitive to medications.  my depression lifted completely within 3 weeks of my start.  i have attempted remove myself from the sertraline with my doctor&#039;s okay...however within a month my husband recognizes my depression and when i am alerted to it i realize i have become very depressed, not happy, find nothing to be good in my life...so i went back on it at 25mg a day and that has worked very well.  i believe my brain chemistry changed after my surgery...it is what it is and i am glad this med. is available."