"i was on imipramine for a little over a year, after trying every other antidepressant known to man. at first i noticed a major change. it was the  best i had felt in years. i was back to doing things that i used to do and felt great. it also helped me to sleep at night. the effects of the med started to decrease so we increased the dose until i was eventually on 100mg a day. that&#039;s when the side effect started. i went in for a routine doctor visit and my resting heart rate was 130. of course panic set in and i had a bunch of tests ran on my heart, everything was normal. the only thing different was the increase in imiprimine. it caused me tachycardia.  so now i am in the process of weaning off of it. onto something else."