"i have had depression forever and after failed ssris mania started to occur. luckily i was already seeing a psychiatrist he tried me on seroquel which made me way too sleepy and then lithium which stopped both mania and depression. although it doesn&#039;t cure bipolar so i still have manic and depressive episodes during stressful times but they are much more minor now i&#039;m on lithium. only side effects are tremors for me but they are fairly minor."