"i suffer from episodic depression and anxiety attacks. pristiq is the only medication for depression that i&#039;ve tried that has virtually no side-effects either getting on or getting off. when i begin taking it (i&#039;m on my 2nd round with this medicine since it came out). i almost immediately (in 2 to 3 days) start feeling better, or at least &quot;normal&quot;. it certainly doesn&#039;t make me feel happy or like dancing, but it does erase feelings that i wished i&#039;d never been born. which is wonderful! i do have occasional night sweating, especially if i take any other medication with the pristiq, even something like advil. getting off the pristiq last time was uneventful. only some slight dizziness upon moving my head for about a week."