"i very been taking hydro 10/325 for about 13 years. this medicine is a life changer! my dosage was at 6 a day with my tolerance.  it was just unbearable to the point that of asking for help many times due to the way i was taking them. basically i took twice the dose i had to really be able to participate in life.  i also have taken many other medications like antidepressants cymbalta, several. i am still taking my flexaril &amp; gabapenton but trying to cut back from 1800mg a day, i&#039;m now sure this is the cause weight gain for me. but in other combinations the prior year i lost over 50 lbs not even trying to. very scary. i have thyroid issues, several biopsies over the years. i have neuropathy low back to mid compressed disc, neck pain &amp; sciatica."