"i am a 77 year old male. my grandfather and my father suffered from depression. i have suffered from depression all of my life. i was first diagnosed with severe clinical depression about 1975. i was put on elavil and the results were very good and i took it for about 12 years. at that time the elavil stopped working and my doctor put me on nortriptyline. that seemed to stop the depression and worked for a long time. when it stopped working, my doctor put me on paxcil. then, a psychiatrist added wellbutrin xl. then my pdoc replaced the generic paxcil with pristiq.   for the first time in 40 years, my depression has gone!"