"i have adhesive arachnoiditis which causes constant severe pain. i had been on many different medications including oxy. i asked my dr to find a medication that would help with the pain and most importantly not give me the &quot;high&quot; sensation. nucynta 250 er and nucynta ir 50mg for break through pain has work wonders!! it doesn&#039;t eliminate my pain but it keeps it at a tolerable level. i have very few side effects. the most noticeable is breaking out in sweats. for no specific reason i will start sweating profusely while in an air conditioned environment.  other than that i get a little drowsy sometimes. nucynta has been a life saver!!"