"i am on sertraline 100mg and 30mg of mirtazapine. as soon as i started taking it it helped immediately- it really helped with my depression but i now need to sleep around 11 hours a night - and as a result i am now registered as disabled with my university. i don&#039;t so much mind the additional sleep - people understand. however the weight gain is harsh.... i have been on it about a year and i have put on about a stone. i now ( when i&#039;m at home) eat very healthily and the weight has started to go- but now i have been on holiday for 2 weeks and i have definitely put weight back on. but for me it is so effective with my depression - when i have sufficient sleep- i will just have to learn to deal with it and change my diet while i&#039;m on this!"