"effective when having a particularly bad day on antidepressants but less effective when not on antidepressants. find anxiety symptoms aren&#039;t overly settled in comparison to lorazepam unless you take a couple. plus they take 45 mins minimum to kick in and during an attack, isn&#039;t helpful. when not taking antidepressants, got up to 45mg on very bad days but was down to 1-2 tabs a month on antidepressants."