"my experience with safyral had been an overall good one, but it didn&#039;t start out that way.  during the first month all through the second month i had horrible mood swings. borderline depression it felt like.  but after the second month it went away, i started feeling better. i&#039;ve had no acne. no weight gain. lighter flows. so i guess this pill is different for everyone based on the other reviews, but this is a great one for me and i plan to keep using it for a long time."