"for years i had been (mis)treated for clinical unipolar. i went through many ssris, but each one &quot;hit the wall&quot; - had only limited effect on the deepest depression, and none as a maintenance drug. changed pyschs. she suggested an off-label use of lamotrigene. within a couple of weeks i felt so much better! we scaled  back (and eliminated) effexor ssri. i continued to get better. she moved away, so i had to find another psychiatrist - or psych nurse. the new psych nurse did an interview, and said i was being treated for the wrong disease. i felt better because lamotrigene was working on my bi-polar! 5 years later, i&#039;m still doing well - mood swings moderated, deep depression less deep and less frequent."