"i have been on tri-sprintec for about 4 years and overall would recommend it to anyone. i have had some moodiness and &#039;depression&#039; but only certain times of the month, and nothing i can&#039;t deal with since i know it&#039;s not real depression and it doesn&#039;t last long. the worst thing about it is occasional nausea. i think taking my pill right before sleeping is the best, and that way i am only nauseated if i wake up really early. i consider these side effects minor after some of my friends experiences of switching pills and all kinds of worse problems."