"i&#039;ve tried three different ssris and one snri and have the same side effect with them all.....i can&#039;t achieve an orgasm.  my psychiatrist put me on trintellix because it&#039;s not suppose to cause this problem....and it doesn&#039;t. on the other hand, i can&#039;t tell much difference in my depression, and i can&#039;t sleep, i&#039;m back to having mild panic attacks, and i feel like i&#039;ve had a breathing treatment with all the &quot;wonderful&quot;, not, side effects.  this isn&#039;t the medicine for me. i&#039;ve only been taking it a little over three weeks, but my psychiatrist is getting a phone call tomorrow."