"tried everything from depakote to lithium and every antidepressant with them. finally paired lamictal (lamotrigine) with lexapro (escitalopram,) and hit the jackpot! i&#039;m unipolar (severe depressive,) and the 300mg er lamotrigine with 20mg lexapro has kept me totally mood-balanced and low-anxiety. after 20 years of different meds, i finally feel like myself."