"i have suffered depression since childhood, also obsessive compulsive disorder and starting in my 20&#039;s major depressive disorder w/ psychotic features and massive anxiety.  i have been on many of the ssri&#039;s and they even tried me on lithium on one occasion, but it seemed to do nothing.  one anti depressant that did work for me for 2 years was nefazadone,  it made me feel normal and even above the normal line.  i am also diagnosed with dysthymia.  one day the nefazadone quit working and i went into a major depression for months.  i currently am on a high dose of venlafaxine, 300 mg a day, but it is working.  about a half hour after taking my morning meds i start to feel a lot better, and anxiety is nearly gone."