"i have taken zoloft and trazodone for past 10 years for depression and anxiety and recently changed doctors. she prescribed cymbalta.  i am on 60 mg and although i have some negative side effects, they are all tolerable. any medicine you take you will have side effects. on the positive side, my libido has increased drastically and i can once again have orgasms. guess i am making up for those &quot;lost&quot; 10 years with zoloft. new life at 59."