"my initial experience  with brintellix is very promising. i&#039;ve suffered from treatment resistive depression and generalized anxiety disorder for many years. name it, i&#039;ve been on it. many medicines flatlined me emotionally, other&#039;s amped anxiety and left me sleepless, others were weight sensitive, causing rapid weight gain (hello remeron); others worked like a charm - until they stopped working. it&#039;s been a 25 year struggle. my new doc put me on brintellix and within short days i felt more alert and &#039;content&#039; with no sleeping problems. no side effects on entry dose of 5 mg. i take 2.5 mg klonopin when required if i have an anxiety peak - other than that i feel like the &quot;me&quot; i knew was in there."