"i started effexor xr (generic version) about 3 weeks ago. i will admit, the bottle sat on my counter for a week before i took my first one, because the negative reviews terrified me. i finally took one and i am so glad i did! i have been on practically every anxiety/ depression med there is and had kind of lost hope with them working. i have also tried several different natural methods and they helped a little bit, but not nearly enough. i struggle mainly with anxiety and have for about 15 years now. by day 3, i had already noticed a difference. it&#039;s been 3 weeks &amp; not only is my anxiety significantly better, i no longer have swollen joints or numbness in my hands &amp; feet, i&#039;m so much happier &amp; way less stressed. life changing!!"