"after 5 years on cymbalta, i cannot say enough about its effectiveness. i really can&#039;t speak to the claims of pain relief, but as far as depression and anxiety, it&#039;s the best i can recommend. the insurance has tried several times to get my dr to prescribe celexa, or effexor, but neither work like cymbalta. initially, i was a little spacy, and jittery, but those went away with time. i&#039;d hate to have to pay for it as is. but, overall, i&#039;d rather not take anything than to have to switch."