"seroquel xr worked very well for me with a combination of seroquel and zoloft together. i&#039;ve been well for over 3 years now. usually i would fall in to a depression with in a year just taking an antidepressent because my body would build a tolerance to the medications. i know this medicine isn&#039;t for everyone, but i&#039;ve had a very good experience and i&#039;m stable and happy."