"i&#039;ve been taking 50 mg pristiq in combination with 300 mg wellbutrin for two weeks, and it&#039;s the best i&#039;ve tried.  this week i&#039;ve been able to handle family and work issues with a sense of hope and able to focus rather than anxiety/ worrying, and that&#039;s awesome.  i had been taking prozac and wellbutrin for years but felt it wasn&#039;t working.  i tried everything but other meds didn&#039;t work or had bad side effects.  this made me queasy at first, but my dr. had said that would get better, and it did.  i take it at night because in the morning, it makes me tired.  so don&#039;t give up!  there is hope.  hang in there. "