"my doctor prescribed this for my anxiety due to perimenopause, 37 mg.  i was always tired on it so he increased it to 75mg xr.  i&#039;m not as tired as i used to be and i no longer wake with anxiety and can sleep through the night.  my energy level is not as high as it used to be before effexor.  my appetite has also increased.  i&#039;ve heard this can be due to a combination of the effexor and menopause.  if i skip a dose, i get headaches."