"i&#039;m a 52 y/o male. i&#039;m on bupropion for major depressive disorder.  in the past i&#039;ve been on zoloft, effexor xr and cymbalta.  there is really no comparison; once i settled in with wellbutrin, i just feel &quot;normal&quot;. i don&#039;t have that &quot;zombie&quot; effect you get on ssris and snris.  my sex drive is fine and there are very few side-effects.

the first 2 weeks were tough. i was extremely nervous about side-effects so i went with the ir version, that way it wouldn&#039;t be stuck in my system for a couple of days if the first dose or two didn&#039;t go well.  i am now up to 100mg 3 time/day and doing fine."