"i&#039;ve been on this for about 8 months so far. i take 300mg at bed time. it helps with sleep, but i do feel a bit tired during the day. this has really reduced my mania. i used to argue with people until i was literally foaming at the mouth, but now i lose interest in arguments within 5 or 10 minutes. twitter and news used to upset me and i&#039;d get ampted up about stories, but that&#039;s gone away mostly. now i can react to things that used to make me furious with a laugh or just a short discussion with someone. seroquel&#039;s not perfect, but the weirdness and intensity i used to experience has gone. it also helps greatly with my ibsd. i haven&#039;t had any weight gain, but my diet is low-fat and limited. seroquel is much better than tcas btw. good luck!"