"started tramadol years ago as an add on medicine with vicoden (hydrocodone) from a car accident shoulder injury. i stopped taking it because the vicoden did the job. then doc told me that new prescribing procedures advised against taking tramadol with vicoden. i switched to tramadol only 100 mg and it works and lasts longer than vicoden or even percocet and i have more energy and i also have chronic depression and anxiety and tramadol does make that go away. it is an unusual drug and seems to work well for some and not good for others. i suppose some people lack the enzyme to convert or metabolize tramadol in to the more effective o-desmetthyltramadol also known as (nucynta) so it doesn&#039;t work for them. well. have a nice day. no pain."