"have had major depressive disorder with borderline bipolar since i was 9, now with added anxiety. antidepressants never worked for me. i am also sensitive to medication. as my episodes have gotten worse, my doctor thought to try me on lamotrigine.  i had to go very slowly up, and at first couldn&#039;t even tell if this was working, until i went up to 75mg, then i crashed. my dark thoughts took over me, i couldn&#039;t stand trying to wake up or get out of bed. my hydroxyzine that usually helps calm me a bit, was no help at all. i was told with being on the low dose that i could just stop it, but then i had bad withdrawal symptoms that took over 2 weeks to calm down. i cannot recommend this medicine."