"i&#039;m a 24 year old female with major depression and anxiety. i&#039;ve been on nearly every antidepressant i can think of (prozac, cymbalta, abilify, lexapro...and even a few others) and effexor has been the only one thus far to be effective. the others either made me an emotionless zombie, or didn&#039;t do anything at all. the only side effects i&#039;ve had were a bit of shakiness for the first week i started taking it, along with some dry mouth. these only lasted a week while my body got used to the medicine. i&#039;ve had no changes in weight or appetite, which i know is a common concern with this class of drugs. if you&#039;ve been through the ringer trying to find an antidepressant, i would recommend this to anyone. i also take buspar daily."