"i started at remeron 15mg per day.  i started to feel somewhat better at two weeks.  went to 30mg at that point.  at 30mg for one week or so, felt appreciably better.  i&#039;ve gained a few pounds (about 4) so that&#039;s not too bad.  did not help with sleep.  plagued by insomnia for 3-4 days after starting and/or changing dose.  a bit of muddied thinking for a few days after changing dosage.  i have severe mdd.  i think remeron will really help. off to a good start.  i especially appreciate the lack of sexual side effects."