"i have been on tri-sprintec for a little over two years now. i never noticed any weight gain due to this pill. when i first went on it i had just lost a bunch of weight (originally looked like a chubby little girl) and after 6 months of being on this pill, i stopped my normal exercising and didn&#039;t pay much attention to my food intake. needless to say, due to my fault, i gained about 20 lbs back - but in a womanly way. i am not sure if this was due to the time in my life - early 20&#039;s or if the hormones affected me, or both. i have slightly higher than normal testosterone levels for a woman, again it could be my imagination, but it does seem that this helps my hirsutism as well. being very sexually active, no pregnancy has occurred. "