"i started taking tri-sprintec to treat acne, and i just finished my first pack. my acne has always been moderate, but after a couple days of the pill, i had a huge flare, but then it went back down to normal after a week or so (normal for me being 2-6 new zits every morning and every night). but, i know it will take 3-6 months for it to regulate my body, so i&#039;ll be patient and wait. i will comment and say that it did have a few negative side effects. i started to get headaches, later in the night. i&#039;m very irritable, tired, and down. i gained a little weight, but nothing that bugs me that much. i&#039;m not recommending against this pill as i&#039;ve only been on it for a month, and everyone&#039;s body is different. just be prepared and wait, they say."