"i have dealt with moderate to severe depression on/off since my early 20s (i&#039;m now almost 40). i have several antidepressants and found zoloft was the only med that worked, so i remained on a dose of 100 mg for almost 10 years. i did try to wean myself off on 3 separate occasions, as i no longer wanted to be on pharma drugs, but every time i had terrible withdrawal symptoms. i finely decided to try st. john&#039;s wort instead. i have been on 900mg daily for close to 1 year. st. john&#039;s wort was helpful in combating the withdrawal symptoms i continued to have even weeks after discontinuing the zoloft, but i continue to have mild depressed mood with irritability. i am going to stop st. john&#039;s wort and try 5-htp."