"while pristiq does work great. i wish my doctor would have warned me about how hard it would be to get off of this medicine. i am in my mid 20&#039;s and my doctor was aware that i wanted to get pregnant in the future. i have had issues with seasonal depression and taken different anti-depressants for a 5-6 months in the past. pristiq has been a nightmare to get off of. i have reduced the dosage as my doctor has said so that i can get pregnant in the future. but i have had horrible vomiting episodes, confusion, brain zaps, terrible muscle pain, sharp shooting pain throughout my body. feeling disconnected. i still have not been able to get off this medicine. i wish you all the best."