"cymbalta is the best medication i have ever taken. after years of being treated for depression, i was re diagnosed as bipolar 2.5 years ago. i have been on an endless parade of ssris, and cymbalta controls my depression and anxiety better than anything else i&#039;ve tried. for the first couple of months i experienced some numbness and tremors in my hands and forearms, but not bad enough to stop the medication; they stopped after 2 or 3 months. i strongly recommend you ask your doctor about cymbalta."