"i&#039;ve tried over 15 anti anxiety and anti depression medications for over 20 years along with thousands of hours of talk therapy. last year i tried tramadol for anxiety and it works for me. i take no other drugs, only 150mg of tramadol pretty much daily. my pcp of many years is onboard with the off label use of tramadol for this reason.  i have no side affects except for a few intestinal &quot;grumbles&quot; now and then. i&#039;m very pleased after all these years to have something that works. i feel like i can breath easier, less fear, more positive, more relaxed but in a good way. not sedated or sleepy. able to do things on my own.  i hope it works for others that have been drug resistant to all the typical drugs."