"lithium did well for me for more than 15 years, but then the creatinine levels went up and i had to switch. eight years later now, i have hyperparathyroid symptoms, at least that is what it looks like. that is a long time after stopping it to see elevated calcium levels, etc.  but i have no regrets. the last 30 years have been stable. depakote keeps me well. just be aware that this could happen."