"when i started trintellix 2 years ago, within a couple days, my mood and energy improved and the physical side effects were tolerable.  as time went on my energy level went down and i started gaining weight (15 lbs )   my muscles were always aching and i couldn&#039;t feel joy or sadness.  i was numb.  don&#039;t ask me why i stayed on it for 2 years.  my cognition was so sharp though.  maybe that&#039;s why.  trintellix made me a bit paranoid and socially uncomfortable ..  anyways to make a long story short, i switched to pristiq 50mg and i&#039;m doing better socially and i&#039;m sleeping through the night.  on trintellix , i was up at 3 or 4 every morning.  i think i would try trintellix again if i ever went into a severe depression again.  take care"