"i&#039;ve only been put on ortho evra recently, so i can&#039;t say anything about the long term. but i can say that lately i have been quite depressed and nauseous. this is only my first month of using the patch, so i imagine that i&#039;ll begin to feel better sometime soon. but its very easy to use and if you&#039;re willing to put up with the side effects for a bit its worth it."