"we have child with periventricular leukomalacia (pvl), he is not 6.5 years old and since 1 year suffered very bad sleeping quality. waking up suddenly in the night, 2am-3am and cannot rest properly until 5am or 6am. very nervous during the day, not having good attendance at special needs school. melatonine, from 2 to 3 mg 1 hr before sleeping, was helpful to falling asleep quickly, but not effective to avoid night wake up or iperactivity. since 3 weeks we started clonidine 0.1 mg, 1 tab night time before sleep, and it works very well. since day 1 he is calm and rests well. few nights he woke up but not nervous or crying/shouting, just calm for a couple of minutes and back to sleep. also at school and during the day he&#039;s more quiet and calm."