"i was on tri-sprintec for a year and a half. it&#039;s very effective against pregnancy, i believe it helped with acne. i didn&#039;t experience any weight gain, however, i did go through a very traumatic 4 month phase before i stopped taking it. let&#039;s see,  i had anxiety attacks. i&#039;ve never in life had anxiety attacks, not even anxiety.  i was moody 21 days and happy the 5 days while on my cycle.  i was paranoid, scared, cried a lot and had rage.  i stopped taking tri sprintec, and boom, pregnant with twins.  but ever since i stopped taking tri sprintec, i haven&#039;t experienced any of those things yet, and my twins are 2 years old"