"i have been on bupropion for about a year, 150mg taken every morning.  i noticed a difference on day 2.  everything was just normal.  not bad normal, but good normal, like you woke up after having a really good sleep - and like a weight or pressure has been lifted.  it&#039;s really hard to describe.  everything seems better. i kid you not.  music sounds clearer, looking around outside, it looks clearer...like i am out of a fog.  so...i tried an experiment while i went on vacation.  didn&#039;t take anything for 2 weeks.  my mood slowly returned to negative.  little things ticked me off, that shouldn&#039;t have.  i decided to go back on.  same effect on the next day, mood lifted.  it gives me slight insomnia, but also takes away some appetite. great."