"after taking 300mgs (100mg am/200mg pm) for three years, it&#039;s no longer working.  when i first went on it, it worked great for both mood stabilization and weight control.  i lost all the weight that i gained after being on zyprexa and depakote, and my moods were controlled well for about two and a half years.  i had minimal negative side effects that seemed to fade after a few months&#039; use.  for the last six months i&#039;ve been struggling with dosage adjustments and adding new drugs to my cocktail while trying to keep topamax.  finally i&#039;m giving up and going off topamax because it&#039;s not doing anything anymore.  "