"i&#039;m on my 10th week of the drug, and it usually takes 12-16 week to see the full effects.i apply it at nighttime, and sometimes apply a layer of moisturizer 15-30 minutes afterwards. it dried me out so much in my first month and a half of use that i had to start skipping nights and use three layers of moisturizer. my skin burned when i would put on my lotion because it was that dry. i now use it everyday and still have 2-4 active breakouts at any given time. i also get a lot of small whiteheads (those may be from shaving my face though) and i extract them myself, which probably isn&#039;t a good idea. my skin is definitely better on the medication than off, i just hope the results are better in 2-4 additional weeks of use."