"zoloft has helped me a lot. i suffered from mild depression and mild anxiety for years. i&#039;m a 38 yr old male. i requested zoloft from the dr. and i&#039;m on the 50mg dose. it started working right away. i felt effects the first night. i was sick the next day but that was the only time. i had some euphoria during the first couple of weeks. next to impossible to orgasim. i have zero anxiety it&#039;s amazing. not as depressed but didn&#039;t fully take it away but really helped. it was the right choice for me. highly recommended. i would make the same choice."