"i have pcos, and was on diannette, spironolactone and metformin for many years. i had taken a break from all the medication i was taking because it just felt like too much - i&#039;ve been on the pill since i was 13, spironolactone and metformin since i was 17 and i&#039;m now 30...not a good decision, because i started to break out terribly. big, cystic acne on my jawline and the side of my face. so i went to the gp and re-started my medication and also was prescribed differin 0.1%. i had been on differin before when i was a teenager but couldn&#039;t really remember side effects. i use clinque 3 step, and exfoliate twice a day. i put the differin on after my moisturiser and eye cream. no side effects as yet and seems to be working....will review again.."