"was taking 10 7.5/325 daily for severe auto immune joint foot pain and nerve pain.  60mg time release. 9 out of 10 days i&#039;m fully functional like a normal mom.  my only issue is ibs... if i take in the am and have my guts evacuate i am forced to suffer with only my 3 daily allowed break through pain medication.  then if i don&#039;t double up the break through the withdrawal symptoms cause my guts to keep dumping.  i have slow digestion and it works about 19 to 22 hours.  i imagine a regular digestive system would burn through this medicine before 24 hours.  i tried it at night first and really enjoyed waking up without pain but had trouble the last 3 hours before the next dose. i would rather spend those wasted hours in bed each morning."