"so far so good. i have been on remeron (30 mg) for 3 years.  it stopped being effective almost a year ago. since then i have tried many other things. finally my doctor suggested seroquel (100 mg at bedtime), in addition to the remeron. i noticed the difference almost immediately -- within 24 hours. severe depression symptoms have eased off and also less anxiety. unlike others, i have had no grogginess with it so far. so, while its early in the game, seroquel looks to be good so far. will post update as my treatment time continues."