"this antibiotic worked wonders for my moderate acne very soon after starting it in november 2016 (in combination with a tretinoin cream). it consistently prevented my cystic acne from emerging and reduced inflammation, i had virtually no breakouts on my entire face. however, it started to lose effectiveness in july 2017 and by august i was seeing discoloration in my thighs. it was like large bruising that wouldn&#039;t heal and it was massively noticeable. i saw that this was a common side effect after buildup of the medication in the system, so i stopped taking it. they&#039;ve since fully healed. i&#039;m continuing to use a topical cream (now differin) but it&#039;s having virtually no effect on my acne, which is now as bad as before. back to square one."