"was on zoloft and then effextor (150 mg) and did great on both, but because i am a long-term forever user i needed to change it up -weaning from the effexor was so horrible.  i am now taking 10 mg and it&#039;s been a week. i am experiencing sleep disruption, some nausea, i am now very regular and my joints and muscles are stiff and sore.  i am finally seeing a glimmer of hope as far as my despair goes - so i am optimistic that the above side affects will go away and all will be well in my world again in a few weeks."