"i have been on contrave for almost a year (40 y.o female). i started out at 240 and now i&#039;m 190. granted it would have been more but after my husband passed away  i didn&#039;t really watch what i&#039;ve been eating and i haven&#039;t been excercising the last several months. when i first started taking it i had headaches and nausea but it didn&#039;t last long. what i love about it is that it makes you not obsess over food and it does keep you in a more cheery mood. really great med."