"i responded after one week. the side effects (lethargy, some bowel problems) are the only reason i didnt rate this medicine a 10. after 44 years of excessive anxiety and depression i finally feel like i can be &quot;myself&quot; instead enslaved to unreasonable thoughts and frustrations. ironically, i avoided these types of meds for years, instead &quot;self medicating&quot; with alcohol and cynicism. had i switched to this years ago maybe i would still be married to a wonderful woman. sad, but true."