"i have bipolar disorder ii, diagnosed 4 years ago. i&#039;ve taken a wide variety of medicines during that time. in my experience, many medications are good for ending a manic episode, but nothing has ever helped me with the ensuing, longer-lasting depressions.  3 months ago my psych suggested latuda, and i agreed with zero expectations of success.  the result has been miraculous.  within a week of starting, all negative feelings were gone.  i experience nausea when i take it, but that is a small price to pay for such a major shift in my well-being.  my appetite remains normal, and i&#039;ve lost 5 pounds since starting latuda because i have motivation to exercise again.  highly recommended to anyone who is bp ii and wants to break out of depression."