"i take wellbutrin xl 300mg every morning for my depression. feeling like i needed a lil something more, my dr. put me on miratapine 30mg daily. i had no side effects with this combo. and i know that many ppl on 30 mg say that 30 mg knocks them out. it wasn&#039;t that way for me. i had no problems waking and starting my day. after 3 weeks... i still didn&#039;t feel any difference. my dr upped my rx to 45 mg a day. i had been taking my wb in the am and mirt at night. when we increased the mirt, i found it harder to fall asleep. and waking up thru out the night. since, mirt is known for the sleepiness at lower levels. i split my rx and took 7.5mg at night and the rest in the am along with my wb. this combo now is working really nice for me."