"when i first went to pm he took me off my 6 x 10mg hydrocodone/day.  i have had triple fusion in my neck, multiple knee surgeries, arthritis, migraines chronic kidney stones so i stay in chronic pain. i was terrified to go off hydros, that has been my only source of pain relief. well. the 100mg er. didn&#039;t work so i had withdrawal from hydrocodone and then the pain was horrible.  i went back to the pm and he upped my dose to 150mg er. twice a day, and 75mg. once a day for breakthrough pain. it was like magic. it was wonderful.  as long as i don&#039;t over exert myself i rarely need the breakthrough medicine. it is great pain medicine once you get the right dose."