"like many, many others, i&#039;ve tried them all. most of the recent ad&#039;s (viibryd, etc) have been pretty mediocre, but i found myself doing at least as well on brintellix as the first time i started zoloft (my reference for a good antidepressants). i didn&#039;t really experience any side effects and eventually titrated up to 20mg per day. after almost a year at this dose, i still haven&#039;t experienced any side effects, find that my sexual response is uninhibited, and there has been no poop-out. compared to all the others, i think brintellix is the best i&#039;ve tried yet. the reason i don&#039;t rate it 10 is that while it has been more effective than other meds, i still feel there is quite a room for improvement."