"i started taking phentermine 37.5 last saturday 4/16 so hasn&#039;t been a week yet. i did lost my appetite i barley eat anything. trying to stick around 500 carlories per day. i have pcos and last blood work that i got done my insulin levels were out of control. i am on 1500 mg of metformin also.  my start weight was 180lbs i weight myself at home this morning and it was 176lbs but i don&#039;t think my scale at home is right so i will just wait to go in 4 weeks for an follow up with my doctor and see if i lost any weight. my goal weight is around 130 lbs. no side effects besides the dry mouth. will keep you guys updated."