"after falling ill with major depression this past spring, my doctor prescribed lamectil.  i noticed a positive change at 50 mg , and am now up to 75 mgs.  i&#039;m looking forward to titration up to 100 and hope that will be the most effective dose, as with fibromyalgia, i am very sensitive to meds. this med has also changed my life as i became non functional, prior to taking it.  i pray the positive effects last, as i was in a very dark place without it.  i take my dose in the morning, as i was having difficulty sleeping at night ( and take melatonin and benzos) for that. my appetite has also not yet gotten back to normal, but i am taking in enough calories to maintain the weight i lost during the depression."