"i was started on 150mg per day and since the 1st day i started i felt an instant relief. i have severe anxiety, depression, irritability, bipolar 2 . i feel so much happier ,a totally different person and so positive and focused. only side effect is some nausea and insomnia but i find taking my meds early in the morning helps me to be able to sleep at night. really enjoy these meds so far"