"i have bipolar disorder with rapid cycling, mixed states, but mostly depression and severe anxiety.  after several years of trial and error i take the following:  seroquel xr 600mg at night, klonopin 1mg 3 times daily, adderall 40mg twice daily, lamictal 200mg twice daily,  and switched from effexor xr 300mg daily to the new antidepressant brintellix. i&#039;ve had the lamictal titrated up to 400mg a day for last 3 years. i don&#039;t think it does anything, good or bad. it&#039;s i&#039;ve never noticed any effect of any kind. i keep taking it because i trust my doctor and it&#039;s cheap."