"i have been using bupropion for 13 years and it worked better than any other antidepressant i have tried. however, as it happens it is not working nearly so effectively. the last 6 months and my doctor is having me also take celexa to augment it. it does seem to cause a decrease in libido and sexual performance. i had no other noticeable side effects. but overall it worked well for me taking 100 mg twice daily for over a decade so i rate it highly."