"my daughter is 12 years old and her depakote was recently increased to 1,000 mg a day. immediately i saw some harsh side effects. to begin with she has a very petite frame and dropped 9 pounds and now weighs 62 pounds. my daughter started vomiting with the high dose. she hasn&#039;t slept a normal nights sleep in a long time. she never wants to eat which has caused her dramatic weight loss. she experiences nausea, vomiting, irritability, and many more side effects. depakote may be a life saver for some but this medication isn&#039;t for everyone."