"i&#039;ve been on deplin for about a year and it has helped me drastically. i was originally diagnosed with bipolar and later, through blood tests, found out my bipolar was related to a condition known as mthfr. i am compound heterogenized meaning i have one of each genetic markers which contributes so a multitude of diseases including mental disorders and circulatory conditions because i do not metabolize folate/folic acid. i was on lithium for 2 years (with horrible side effects on minimal doses) and since being on 30mg of deplin plus 5000mcg methyl b12 i&#039;ve been taken off the lithium completely and have normal mood changes."