"i was prescribed aczone for hormonal adult acne. the first time i tried it i was instructed to use it once daily in the morning and at night to apply retin a cream. it caused my face to get extremely oily and did not seem to do anything to help the acne. so i stopped taking it for over a two years finding oral antibiotics to be the only solution. however, recently my dermatologist suggested i try aczone again. i increased to twice daily, once in the morning and once at night. i saw results within a day and my face had almost completely cleared by the end of the week. i still use the retin a cream at night in addition to the aczone and it seems to be my new acne solution. i think using it twice a day was a must for me."