"i started taking sertraline last night for severe depression and anxiety. i can honestly say that within 1 hour of taking it i felt a little better (anxiety had gone) and my mood lifted albeit slightly, today i feel slightly nauseous  and a little anxious. just praying that it works on me as it has on others i&#039;ve read on here. tried pretty much everything else so we&#039;ll see, first signs are good."