"i was on 100 mg of zoloft for 5 years, and went through a stressful point in my life. i became depressed, crying every hour and wouldn&#039;t leave my house. i went to the doctor and he said the zoloft wasn&#039;t working anymore and wanted to switch me to lexapro (escitalopram). the withdrawal from stopping zoloft was brutal, but my lexapro started working within a week. i am now on week two and feel amazing. i am going places, and not as tense as normal. the only downside is i&#039;m very irritable but hoping that goes away soon"