"i&#039;ve tried just about everything on the market for depression, and i can tolerate almost none of them.  the first dose i took of vilazodone was only 5 mg (cut a 10 mg in half), because i am extremely sensitive to medications.  within a a couple hours, i had lost a lot of muscle control and felt very weak.  it scared me, but i also felt incredibly calm and happy.  once the side-effects wore off, i was afraid to take it again but intrigued at how good i felt.  i then cut the 5 mg in half and have taken 2.5 mg for the past two days (you definitely need a pill splitter) i have had none of the muscle side effects, but definitely had intestinal upset this morning and a little drowsy.  i am going to try taking it at night to see if this helps."