"i am a physician and tried really everything on my acne, which last now for 24 years. it started during puberty and has been hormonal since then. i have been once put on anti-androgen medication, which was quiet bad considering me being a very young women. but since than nothing helped. spironolactone was well known to me as diuretic, but not as acne medication (off-label use). but i gave it a try, was quiet concerned about the potassium retention, but what do i have to say: acne almost gone, no water retention before my menstrual bleeding (gained always about 2-3 kg) and something i would not have thought: no further cramps in my legs, which sometimes woke me up at night. i am very happy about taking spironolactone."