"i am 25 years old and have been on depo-provera for around 3 years. i have very little side effects &amp; absolutely love not worrying about pregnancy or periods! i can&#039;t imagine going back to having a monthly period, i am very content with my light spotting every three months a week before my next shot. i never plan on having children so i have no problem staying on this long-term. i&#039;ve been losing/gaining 20 pounds on and off many years before i started depo, and considering i do not exercise i cannot blame any weight gain on this. my only concern is bone density loss. i eat calcium rich vegetables daily &amp; take vitamin d, but may start calcium supplementation as well depending on my results from a bone density screening."