"warning! i received two injections, and it was the worst 6 months of my life. this should come with explicit warnings, but didn&#039;t.  i came down with severe anxiety and depression.  my life fell apart and i had to leave town to regroup.  my interpersonal relationships unravelled. i was so depressed i couldn&#039;t move.  i saw a pyschiatrist and he suggested that the depression could very well have been due to the depo shot - he&#039;s seen it affect others like this as well.  also, i rapidly gained 15-20 lbs.  it&#039;s been 8 months since my last injection and i am ecstatic to report my period finally came back. it can take that long to leave the system! this is a dangerous drug. monitor your mental health closely. in fact don&#039;t do it"