"i&#039;m extremely sensitive to the side effects of these medicines. remeron is the only one i can tolerate (and it doesn&#039;t give me enough relief by itself). brintellix&#039;s side effects reminded me of pristiq&#039;s--falling asleep during the day, not able to sleep at night but it worked on my interstitial cystitis and it reduced my appetite, so i&#039;m going to give it a longer trial in the summer when school is out and i&#039;m not working."