"i went on doryx almost 3 months ago because i had severe cystic acne. it was awful, i was mortified to the point where i would even call out of work. not only was it embarrassing, but at times it was also painful. my dermatologist put me on doryx and i noticed no change until about the 6 week mark. by the 8 week mark my cysts were gone! it took time, but i am so glad i stuck with it. i have had people tell me how much better my skin looks. it is not 100% clear as it had been a year ago, but i am very pleased with it so far. the doctor told me it takes up to 6 months to get the full effect. so be patient. in addition to the pill i also wash my face once a day with neutrogena red reducer (green), proactive and i use clinique acne foundation."