"2 years ago my step daughter was diagnosed with severe anxiety and depression. she couldn&#039;t go to school, she was suicidal and completely dysfunctional. she has been on zoloft since then. we decided with diet and exercise to spend 6 months weening her off the pills which was hard. i read about niacin and we came off of zoloft and immediately into this. 3 pills a day, which would make 1500mg. the flushing subsided very fast for her. on day 3 she went for a run, voluntarily. on day 4 she said she would join soccer. 3 weeks in she was better than ever before. i thought, its a fluke and when her pills ran out i accidentally bought flush free niacin. it took one day to bring her down. niacin works, she said it lifted the fog."