"single administration of vortioxetine was only partially useful for me. not satisfactory. i would rate it 50 out of 100. could keep my office job, but my hypersomnia with excessive daytime sleepiness and non-24 hours sleep wake problem still disturbing and &ldquo;painful&rdquo;, made me want to quit the job and rest at home.
then a doctor started to add venlafaxine (and later on desvenlafaxine) and imipramine 10mg, starting from 2016 august. there was signifcant and noticable improvement as dosage increase. my current dosage is : vortioxetine 20mg + venlafaxine 112.5mg + desvenlafaxine 50mg + imipramine 10mg + melatonin 3mg (this dosage was reached on 2017 may 6, and today is 2017 aug 11)
i would rate this combination 75 out of 100."