"without a doubt, st john&#039;s wort works for depression. i have been on 3 different ssris and none have had the effect st john&#039;s wort has. it has calmed insesent worrying and has all almost completely recovered a fairly moderate depression. i have had side effects of dry mouth, altered taste, slight tingling and a lowered appetite bit these side effects are much gentler than the sledge hammer side effects i usually  get from ssris. overall, a really great herb with fairly amazing mood altering effects."