"developed flu like symptoms the evening after i took first and only dose. soon after developed acute hives and ill feeling for several months then additionally turned jaundice. went to gi and connected it to the minocycline.   took 3-4 months to monitor and bring liver levels back to normal (they were elevated 16 x the norm).  had similar situation 5 years back but hadn&#039;t connected it to the minocycline at that time.  had used the minocycline for a few months then. must have developed severe reaction now to cause so much trouble with just one dose. red cross won&#039;t accept my blood donations now.  bad stuff. don&#039;t recommend it to anyone"