"i have been on nucynta for 1 1/2 yrs. i&#039;ve had major problems with pain meds. vomiting, not sleeping to very high liver counts. i&#039;ve had 4 surgeries on my wrist in 3 yrs. 1 being a internal amputation of the ulna hump &amp; approx 3&quot; of bone. picture that hump in your wrist &amp; 3&quot; of the bone that is attached to it gone. bone hitting bone, pain i wouldn&#039;t wish on anyone. my pm put me on 50mg x 2-4 times a day. for the 1st time in 14 yrs i&#039;m almost pain free. i&#039;m going this week to have the dosage increased. i had to stop working and i never thought that i would have a normal life or be able to hold my grand kids. now i have 6 grand kids and i spend everyday with them. i can even pick them up and hold them. my newest is 8wks old. nucynta saved me."