"been on it for about 1 1/2 years for insomnia and mood swings (bipolar 2) tried a few other drugs but this one works best.  i have gained weight but i am a calmer, happier person on it.  my sleep schedule has settled over time.  initially i slept too much (10 + hrs) or was tired during day.  settled finally on 2 generic seroquel xr50&#039;s about 3-4 hrs before bed and that works pretty good for me.  don&#039;t know why it takes that long to kick in but it works so i don&#039;t care about why."