"my experience with latuda is mostly negative. i have been on it for 5 months and will be tapering off in a couple of weeks thankfully.  the only good thing about it is it stabilized me in a severe mixed mania with psychosis episode, but other than that, the side effects are horrible.  it has done nothing for my depression the past two months and i have had anxiety and major irritability on it.  the nausea and vomiting is miserable.  i was prescribed zofran to offset the nausea but that is not so helpful either since the zofran causes constipation.  the 350 calorie requirement is a pain because you can&#039;t take it with dinner or you fall asleep instantly, so i take it with a late night meal to last a few more hours, hence more weight gain."