"have been taking 300mg for 3 weeks now.  i had horrible side effects in the beginning (for about a week) - almost unbearable nausea, diarrhea, sweating, vertigo, headaches, confusion and i felt like i had the flu.  now i have migraine headaches that last almost all day and ringing in my ears.  i still feel a little foggy sometimes but that is a small price to pay for my depression being pretty much completely gone.  i finally have energy and i am shocked at how quickly it worked.  i was suicidal for months while on 225mg of effexor and this has been a life saver."