"paxil worked absolute wonders for me for six years until &#039;pooping out&#039; last year. after a disastrous few months on zoloft i returned to paroxetine which again has made me &#039;return&#039; to my old self. my alcohol increase (due to work issues) was almost certainly the cause for the medicine becoming ineffective and my return to anxiety and depression.  many reviews claim ssri&#039;s don&#039;t work as well the 2nd time which is slightly true. i feel normal again without the &#039;serotonin high&#039; i had first time around. paxil/paroxetine is a miracle for me and though it has killed my sex drive and gained my weight slightly i cannot imagine life without."