"i have had hypothyroidism since 1999 and battled weight my whole life. i recently put on 20 pounds over this last winter as i suffer from winter depression and do not get any activity in my life. my docotr has never prescribed contrave before and decided to have me try it. i started it 6 days ago at 217.6 pounds - today i am at 215.0 - to date i have not noticed any side effects but i also have not noticed any decrease in my appetite. i am hoping the appetite decreases as my dosage increases. my insurance covers this and i am only paying $40. there is also a discount card on the contrave website if you do not have insurance."