"i have been on pristiq for 2 and a half weeks. the first day i was nauseated but i ate and felt much better. the first week i was very hyper in the morning when i took it. i could not drink my usual cup of coffee. the late afternoon i felt tired. this week i feel much better not hyper at all. i feel somewhat calmer and my husband agrees. i have lost 4 pounds so far and that is great. i have hypothyroidism and gained 10lbs from synthroid. i am taking pristiq because i have mood swings and horrible pms. i do hope i feel more of the effects of this medication in the next few weeks. i was on wellbutrin and celexa before but had side effects. pristiq has been awesome so far."