"on my fourth week of taking 50 mg of spironolactone. was put on this medication for cystic acne. improvements i&#039;ve noticed are definitely less oil and blackheads have cleared up, however i am still battling cystic acne around my chin/mouth and occasional pimples on my forehead. i am thirsty quite a lot and subsequently pee a lot too, but have not noticed any weight gain! skin on my cheeks have been very dry. fighting both cystic acne and cracked skin is a hassle. i&#039;m hoping by next month i will see improvements in my cystic acne and not continue to worsen."