"i had to switch to a new contraceptive after being on depo for 5 yrs. since i was used to having no periods on the depo my doctor okayed me to take only active pills and never take the placebos. after 4 months, i started getting breakthrough bleeding on and off for the next 6 weeks. it did it&#039;s job, since i am baby-free, but i couldn&#039;t keep taking it from all the random bleeding for almost 6 weeks. while on it, i had headaches for the first few weeks, but they subsided. i was definitely more emotional while on it the first couple months, but that leveled out mostly. i still would cry easier, though. the good thing is that i did seem to have a little bit higher sex drive. "