"i&#039;m 24 yrs old, have severe ra and been talking seroquel xr at 300 milligrams a night for nearly a year.... i was diagnosed bipolar 2 years ago but had so much trouble finding a psychiatrist who was caring enough to listen to me (like a psychologist and work as a psychiatrist, pill pusher) so my diagnosis went treated and untreated on and off for a while.   but since i&#039;ve been seeing my doctor regularly and she seems to genuinely care i&#039;ve trusted her judgment with her diagnosis and what she thought would help me most.... besides the weight gain, honestly i feel much more stable &amp; i can deal with the world around me as i see it and haven&#039;t had any serious depressive episodes or hypomania. this medication has worked wonders for me."