"doc put me on wellbutrin two years ago, while in an oxy detox program. i also suffer from depression and general mood swings, and chronic lower back pain (thus the oxy history). i take 150 xl once a day, before going to bed. i never had any side affects, i consider myself lucky to have found something that really works for me.... it helps me keep stable, focused and generally in a good mood. a few months ago while on vacation i lost it and went three days without. no adverse effects other then less energy and when i told my doc, he said i might as well go without then. i just took my first pill again last night. going without really started to show... lack of energy, wow!! depression, etc. first morning back on, and i feel much better!"