"i have been on anti-depressants three different times in my life. i was prescribed effexor first, five years later cymbalta and recently cipralex. of the three, this has by far worked the best for me. one theme i kept reading during the early weeks when i first started taking the meds is that if can be a bit of a rough ride tapering up. that was the case for me. at first i felt totally out of it and also experienced difficulty getting to sleep. it has now been five weeks and i am taking 10mg. the problems getting to sleep have slowly gone and i feel better each day. my mind is clearer than it&#039;s been in months and i don&#039;t have the crazy irrational worry and ocd that were some of the reasons i was prescribed this in the first place."