"i went through a very bad depression state a few weeks ago. i went to the hospital and they put me on 75mg of effexor-xr and increased it to 150mg after a week. i had severe bladder cramps and waterworks problems while on the higher strength. my doctor reduced the dosage to 37.5mg once every 2 days. i now feel fantastic. one of the main things i have noticed since taking this medication is this. for about 35 years i have suffered with extreme pain from t.m.j(an inner ear problem). since i have been taking this medication the t.m.j. has gone and i can sleep 8 hours at night, the first time since i was a baby which is 53 years ago."