"apparently, different meds affect different heads.  i have not had a problem on this medicine (venlafaxine) as long as i take the 150mg each morning.  it seems to take the edge off anxiety and depression so far (been on it for several months).  i have had severe problems on other meds, so it&#039;s an individual tryout.  keep in mind that i started at 37.5, then doubled, and then doubled again.  this gives time for your body to get used to it, i suppose.  my weight has been the same, but i sure would like to see the weight-loss that some people mention.  like i said, it&#039;s an individual tryout, so no guarantees it will work for you too.  give it plenty of time, and start small."