"i have been on the depo shot for 3 years and for the most part it does keep you from getting pregnant. my first 2 years on the depo went quite smoothly but i have noticed that it made me very depressed and messed up my sex drive, but the last few months i&#039;ve been noticing that i&#039;ve been very moody, depressed, spotting, nauseous every other day, weight loss &amp; i&#039;ve also been feeling very dizzy and weak. i&#039;ve also heard that it takes a while to get pregnant once you get off so i do not recommend, i will not be getting another depo shot &amp; i regret ever getting it."