"i have had no problems on this medication. was switched around to a couple different other generics for alesse for 2 years.  i have been on orsythia, specifically, for over 6 months have seen no difference with this and the others.  i have had no side effects at all. orsythia/alesse has helped my mood and my adult acne.  it has also made a major difference with my periods.  now lighter, shorter with little to no cramping."