"i have been on contrave since august, 2016.  to date i have lost 45 pounds and have not experienced negative side effects.  i am able to say no to second helpings and often decline completely foods that i would have readily consumed in excess a year ago. i follow my doctor&#039;s instruction to take this medication with a lean protein and i have found this to be  effective for tolerance of contrave.  the two times i took contrave on an empty stomach i felt nauseous, so i simply don&#039;t take it on an empty stomach.  for me this has helped me tremendously.  i can walk and run farther and faster and my blood pressure is stable for the first time in about 6 years."