"i have been taking pristiq for 1 week. 43y male. first time treating depression. i could &quot;feel&quot; a difference within hours. hard to believe maybe, but it was a slight improvement. every day (every single day) has been better than the one before. it is gradual, but very noticeable. my wife says &quot;you are coming back&quot; and my son says &quot;thank you for not freaking out so much&quot; and my co-workers are noticing. i even told a joke in a crowd this week (instead of just feeling like i want to leave and be alone) - i am amazed. i had sweats and some minor side effects in the first 4 days, but they are completely gone. i am so thankful for this medication. thank you to the scientists who developed this. you are changing my life for the better!"