"i was on depo for 5 years and just got off of it 3 months ago to try and conceive.  i had never been on any other type of bc with which i could compare it. i found it nice having no period (no planning ahead for trips, no having to buy tampons!) though it did contribute to an unpleasant vag dryness which i could have done without. luckily i did not gain any weight in the 5 years of depo, the only caveate being that i monitored my weight more than the average person ever would and i have always exercised and eaten healthy. with that said, however, i did find that i had to try a lot harder to maintain my weight than before depo. i did not notice any other side effects. having been off it i noticed i am more fatigued than usual."