"i have tried abilify (worked but caused massive weight gain) and latuda (worked at first, then just made me restless and agitated) and now vraylar for depression/mixed episodes in bp ii.  i have only been on it for about a week, but i noticed a huge difference in my mood and agitation. i do not feel depressed and hopeless, and am no longer agitated at all. i hope this med continues to work! it is very expensive, but you can go on the website and get a savings card where you only pay $15/month."