"i have been on lexapro for 4 years and have gained 40 lbs.i have always been able to control my weight, but have gained steadily 10 lbs a year since beginning lexapro. other than the weight gain, overall, i felt like i was doing good on lexapro until the last 6 months or so and even tried to get off of it, but was not successful. i went to see my doctor and she switched me to pristiq. i feel so much better mentally and physically. i have been able to drop some weight and feel that there is hope for getting these extra pounds off.  i&#039;m not nearly as lethargic and wake up in much better spirits than i have in a while. i am hopeful this medicine will work for me and that i am also able to lose the weight."