"i have been on tramadol (50mg 3x per day) for about 6 years now.  for the first few years is was a miracle cure.  i have struggled with depression/anxiety/impulse and obsessive disorders my entire life.  this made me finally feel free and human for the first time ever.  the only downfall was after a few years, the effects wore off, and slowly my depression/anxiety began to creep back in.  i took a break from it for a few months (warning: withdrawing from tramadol is reallllly uncomfortable).  i went back on it after my dr assured me it was a good med (even long term) for fibromyalgia/depression, etc.  i&#039;m up to about 4/day now.  it still helps, but not nearly as much in the beginning."