"i thought i would share my experience as it may be helpful to others.  i have been on this for over 2 years now... and depression wise (which is what i&#039;m basing my rating off of because that is what this rating is supposed to pertain to) it hasn&#039;t done anything for me at all.  at least nothing at all that i have ever noticed. i have stayed on the medication because of the fact it does help bring down my homosistine levels.  i have a condition referred to as mthfr.  basically it&#039;s a liver enzyme condition that makes it so the body doesn&#039;t convert proteins/peptides very well. common condition (1/10 americans) but rarely tested for. the lab had to look up what to do for drawing blood and testing for it."