"within two weeks of starting to use clindagel, i had great improvement. i have never had any side effects; i may as well be putting water on my face in that regard, except for how great my skin looks. i have combination skin that&#039;s leaning toward needing some anti-aging help, and so i use the gel at night after washing my face, and mix a little of it with my day moisturizer. the other reviewer makes a good point about benzoyl-peroxide. when you need a little more help than the clindamycin, mixing in a little of that really does the trick."