"i&#039;m a 21 year old female and have suffered with depression and horrible thoughts for as long as i can remember. i was started on one medicine, (can&#039;t remember what it was), then zoloft, which did not work, and was recently put on cymbalta about three weeks ago. my depression had gotten so bad that i was willing to try everything. i was having emotional breakdowns at work, having horrible thoughts, bad dreams, and was withdrawn from everything. my depression is a brain imbalance, rather than caused by other things. only being about two weeks on cymbalta, i can already notice a difference. i&#039;m more peppy, i don&#039;t think bad thoughts nearly as much, much more patience, haven&#039;t cried since i&#039;ve been put on the medicine. i was a little jittery at first."