"wellbutrin is the only antidepressant that has worked for me. i&#039;ve tried 7 other kinds and all made me worse. wellbutrins initial side effects were mild, mainly headache and nausea. but i noticed i was happier and more worry-free after a few weeks. i have to admit that this medicine made my appetite worse. i know its sometimes prescribed to help with obesity but it made me gain weight. if you are a smoker be careful because it will make you sick if you smoke, which is why i was able to quit smoking."