"i am suffering very severe back pain due to a ruptured disk l 4-5. i have been on nucynta for two weeks now. i started with the blue pill 250mg twice a day (every 12 hours). the pain subsided with first dose within 45 minutes. all i felt was a warm fuzzy sensation throughout my body. i was somewhat tired but not too bad. i felt detached for some time, like i was not in the room. i had some difficulty remembering what i was going to do. i decide to do something and a few seconds later i could not remember. this happens quite often after i take my dose.  all in all, i am very happy with this medication for pain. it really does help."