"it&#039;s been about 2 and a half weeks off depo now and i&#039;ve seen a huge difference, in my mood, and in my skin especially. i was on the shot for about 2 years. the first half of the first yet i bled, not enough to need a tampon but enough to annoy me from time to time. it goes away. the last 6 months of using it i noticed a huge change in my skin. i&#039;ve never had a problem with acne but after a year and a half on depo i started getting pimples on my forehead that wouldn&#039;t ever go away. i&#039;ve never had problems with weight gain but did notice it made me a little more emotional then i had been off it. as for protection against getting pregnant it worked 100% on its own."