"vyvanse has been a fantastic medication. it is far better than other medications that i have tried. it last all day and when you take the right dose you don&#039;t notice it kicking in and you don&#039;t notice it when it wears out. i take it first thing in the morning at 5-6. i was taking 20 mg and that seemed to work well. i am currently on a two week trial with 30 mg to see if this works better. this is a medication where it works best when you find the sweet spot. just because you don&#039;t notice an initial buzz does not mean it does not work. the other very important factor is caffeine . this should be keep to a minimum as the combination will light you up . if you feel anxiety, don&#039;t have any coffee, you will. see a real change. (:"