"i have taken this medication on two separate occasions: first in conjunction with seroquel (quetiapine) and neurontin (gabapentin) and second by itself without other psychiatric medications. both times i took the 150 mg extended release form. when i took it the first time i didn&#039;t experience any mood-altering effects, but i did lose a significant amount of weight. in fact, my psychiatrist had to take me off the medication when i dropped below 90 lbs. the second time i took bupropion was when i had to come off lithium due to thyroid damage. this time it was life changing. all of my depressive symptoms melted away without inducing any hypomania. i still lost weight, but not as much this time around. this medicine makes me feel normal again."