"tylenol with codeine #3 does nothing for me.. plain aspirin is more effective. i have been prescribed codeine several times, many times even, over my lifetime, and each time. it seems as if i took nothing at all. i don&#039;t know why, but i just shake my head and even laugh, when they prescribe it.. after trying it yet again, thinking it was just a mistake, or they made it better.. again, it does absolutely nothing to relieve pain. i take several of them, and usually about halfway through the prescription, given me by the doctor, i switch to plain aspirin, to get some relief from pain."