"i just hit the 1 year mark taking the depo shot and decided to get off of it for multiple reasons. i was bleeding the first 3 months straight  i was on it but they assured me it would go away and it did. i has mood swings like no other but the biggest turn off for me was the weight gain. i gain 31lbs over a year time frame while going to the gym 3-4 times a week and eating healthy. i thought something was wrong and so did my primary doctor so he did blood work on me an i&#039;m as healthy as a horse! he mentioned my birth control and it all made so much sense. my friend and i started it around the same time and she was 123lbs, a year later she gained 36lbs and almost weighs 160lbs. i also lost my sex drive."