"i have recently been prescribed tretinoin 0.25%. i have been applying it for about a month now. at first my skin was terribly dry and painful. with the use of moisturizer it&#039;s not noticeable. i apply the medication at night before i go to bed. my acne has not gone away yet but my skin is much smoother and any new zits that do pop-up are gone immediately. from the experiences of other people, sounds like this medication just needs time and a patient with patience!"