"zoloft was the first anti-depressant i tried and it worked well enough that i stuck with it. the first 2-3 weeks were difficult. i found myself yawning constantly, extremely drowsy, having no appetite, nauseous when i did eat, thinking about doom and death. but those were side effects that all eventually subsided. i feel a lot better because i have more control over my emotions and anxiety. i cry much less now and don&#039;t lie in bed at night thinking about suicide as much anymore. i went down in dosage from 75 mg because i felt a little too muted, like things that were really supposed to bother me didn&#039;t, and the nausea on 75 mg really sucked. i was finding myself vomiting for no reason. 50 mg has been good to me the last 6 months."