"my pyschiatrist put me on duloxetine 30 mg. in the beginning of 2 weeks my appetite decreased and also i felt more worsening of depression. it took me 4 weeks to actually kick in this medication and i am improving day by day now. i am more social and enjoying my life. i want to say to all of u is that take this medication time. it takes time to actually kick in and also side effects will go away. thank you cymbalta"