"i started taking pristiq 100mg last july. initially i had headaches, mood swings, anxiousness and found it hard to sleep. this lasted about a week. with the initial combination of melatonin i was able to get into a routine of taking the pristiq in the morning and melatonin at night, both roughly at the same time to sleep the same amount each day. for nine months i have taken pristiq by itself now and have found that it has significantly decreased anxiety, stopped me from internalising almost completely and has reduced my mood swings considerably. i have slightly reduced sex drive, put on a bit of weight and a want to smoke and fidget. i have found pristiq beneficial to my life but frustrating at times."