"i have been taking 15mg of oxycotin 3 times a day.  recently given palexia 50mg to replace a dose of oxycotin.  gives me a bad headache and nausea but seems to reduce the pain same as the other meds. it stopped working and i have continued with the midday dose of oxycotin and use palexia to top up before bed. i often have to take ibuprofen to get rid of the headache. not sure these are very helpful as morphine tends to make me more cranky than i would be on oxycotin."