"i&#039;m not usually one to publicly review medications, but i really feel the need to with this one. i have been clinically depressed for about 6 years. i have tried celexa, lexapro, zoloft, prozac, and effexor.  trial and error is really a bummer when you want to get well and you have little to no relief. i am now on a mix of 300 mg of wellbutrin sr and 100 mg of zoloft and love it! the first week or two i experienced some nausea (the traditional side effect) that had me down for the count for a few days, but i stuck with it. my only complaint after about 4 months of use is the insomnia, but that&#039;s nothing melatonin can&#039;t fix. so, if you&#039;ve tried every ssri/snri under the sun, i totally recommend trying wellbutrin."