"i was diagnosed with bipolar/severe mania and depression since i was 26, i have see every psychiatrist in my area, and have been put on every antidepressant from paxil to effexor. the only one that ever worked is nardil. i am 33 years old now and would recommend this monoamine oxidase inhibitor to everyone who needs to be on an antidepressant.  i was fortunate to find a very  intelligent doctor who worked with me through these years.  he told me not too many doctors prescribe nardil for the food restrictions or whatever, but i personally believe the &quot;old school&quot; maoi&#039;s are the way to go. nardil gets a 10 in my book.  i felt the ahhh, effects after one week."