"i&#039;ve been taking bupropion 200mg for roughly three weeks to treat bipolar depression. i have not had success with any other antidepressants. for me, wellbutrin has been great.  it has increased my energy level dramatically, as well as improved my mood. it&#039;s not a cure all, but it&#039;s certainly helping. the side effects - i take it in the morning to avoid trouble sleeping. increased my anxiety somewhat the first week. higher libido. markedly reduced appetite. i need to remind myself to eat, and i&#039;ve lost 5 lbs.  others have mentioned a bad interaction with alcohol which i have not experienced. i&#039;ve had up to three drinks with no problems. my overall experience has been good, this is a great medicine if it agrees with you."