"i have been on benzodiazzepines on and off since i was 20..i&#039;m now 51. specifically, clonanzepam for the last 3-4 years. it&#039;s the only one out of the many medications that i&#039;ve been prescribed over the last 30 years that remains effective. i&#039;m also on methadone. many studies state that there is a major interaction of these two medicines. i have been on this regimen for almost 4 years and it has been nothing but helpful in maintaining a &quot;normal&quot; lifestyle. whatever &quot;normal&quot; is!"