"i&#039;ve been on zoloft for almost a year now. i will be changing medicines in 4 days, which makes me really anxious. this drug worked well for my depression and anxiety. however, i&#039;ve been completely unable to have a good time while on this medication. i can&#039;t bring myself to go out, hang out with friends. i do nothing. i have no motivation. the biggest problem i&#039;ve had with zoloft is extreme weight gain. i&#039;ve gained 50 lbs in the year. "