"i started taking orsythia about four months ago. this was my first experience on birth control, so i was incredibly apprehensive about the side-effect, namely: migraines, birth control, and  mood swings. the first two months, everything went so smooth.  these last two months i have been shocked with the adverse effects i&#039;ve experienced. i have had issues with water-weight gain, which fluctuates between 3 and 5 pounds, and nausea. but, the biggest issue i have found with this medication would be the anxiety and depression. at first, i chalked it up to stress. however, people around me noticed that i have not been myself. i&#039;ve felt edgy, irritable, overwhelmed, confused, and sensitive. i&#039;m finishing this month, then switching to a new pill."