"i have been on everything from concerta to wellbutrin to vyvanse. next to vyvanse, adderall xr has been the most helpful. if i take it any later than noon, i will absolutely have insomnia. i also have to be careful about the foods i eat, and especially try to avoid my multi-vitamin in the morning (because of the citric acid). it doesn&#039;t decrease my appetite, sometimes i feel like it increases it, but it prevents me from binge-eating. i take 20mg adderall xr with 25mg of zoloft and though it helps with my ocd tendencies that adderall is likely to cause, i don&#039;t think the combination works as well as adderall xr by itself. i will also occasionally have heart palpitations, but that&#039;s usually a sign that i need to limit my coffee intake!"