"only on day 4 of pristiq, 50 mg, but definitely feel a difference. yesterday was the first day i didn&#039;t feel like getting through the day was going to kill me. had a miscarriage 3 1/2 weeks ago, but always had disthymia (clinical depression.) tried everything you can imagine before. celexa helped but stopped working a year ago. also gained weight due to antidepressant. i&#039;ve lost a pound or so this week since starting pristiq, and i don&#039;t feel so hopeless and sad since yesterday. i am smiling again, laughing again and making jokes. i&#039;m not feeling as happy as i know i can, but i&#039;ve only been using pristiq for 4 days. i&#039;m looking forward to continued results. side effects? if there are any i haven&#039;t noticed as i&#039;m still dealing with miscarriage."