"i&#039;ve been on depo for about a year, and at first i absolutely loved it. no periods and no noticeable side effects at first. however, i started noticing frequent mood swings and often feelings depressed. on top of that, i have also had painful intercourse and my obgyn says this is because of decreased estrogen levels which cause women to be less &quot;wet&quot; - which she said is very likely to be caused from the shot. i&#039;ve also had serious trouble losing weight since i&#039;ve been on the shot. don&#039;t do it!!"