"i started 150mg of wellbutrin xl in jul 2013 due to feeling very unmotivated, depressed, tired, and hopeless. after a few days i felt good, and by the second week i felt better than i had in several years. i increased the dose to 300mg in oct because i was starting to feel down again. it helped a lot but by jan i was very irritable/angry/bitter, so i lowered the dose to 150mg and restarted 40mg of prozac and the anger subsided. to address some side effects: inability to fall asleep (went away after 2-3 weeks), increased libido (awesome), pretty much the same appetite (no weight loss or gain), vivid dreams (sometimes disturbing), more emotional (but not crazy/extreme), constipation (moderate-severe), sensitivity to caffeine (must avoid)."