"i have polycystic ovarian syndrome. i have been using depo since i was 15, and i am 17 now. even when i took the pill (which regulated my periods), my periods were abnormally heavy and i did not want to deal with it. i like using depo a lot. i have taken a bone density test about 3-6 months ago and my bones were great; you just have to make sure you are taking calcium and vitamin d. the only negative side of using depo for me are the mood swings that happen after i get the shot and last for about a week or two. i don&#039;t get any other pms symptoms and i have never spotted. although this is important: do not be late on taking your shot! i did that once and i had my period."