"i have tried everything, even asked my dermatologist for accutane after reading the horrible reviews, that&#039;s how  desperate i was. she prescribed spironolactone &amp; after 3 months, my skin is clear! i did gain about 15 lbs, but hey, i can lose weight, whereas i  couldn&#039;t clear up my skin on my own! i noticed a slight feeling of depression in the first little while. but that&#039;s gone. also, i started out with 50 mg &amp; went up too 100. i think if i would have waited a bit longer i wouldn&#039;t have needed to &amp; that may have helped the weight gain. but i&#039;d do it all over again!"