"first week on cymbalta and i can report that it is certainly effective. i have severe recurrent depression with some psychotic symptoms, and have been on lexapro, prozac, tried natural supplements etc.... nothing worked too well. i&#039;m also currently taking wellbutrin and that helps with energy. still early on, but i can already tell a decrease in suicidal thoughts, delusional rumination and such. of course it&#039;s not without side effects. dry mouth, nausea, constipation, emotional liability (random laughing and such), dizziness, orthostatic hypotension (lightheadedness upon standing). "