"i have taken sprintec for over a year now.  biggest side affect i had was with my hair and nails.  for this first month i thought i might loose all my hair, but it just got a lot thinner, which is ok for me because i had really thick hair.  my nails became softer and have very small ridges.  they tear easy now, but the debilitating cramping has completed subsided which is why i take the pills.  no weight gain, nausea or mood changes for me."