"i took this on top of taking sam-e for depression and fatigue. i&#039;ll put the good first. this supplement is amazing. makes me feel much more confident, much less socially anxious, and more able to be assertive, and have no fatigue. and i am interested in things again. i feel joy from looking at the mountains and such. it started increasing my facial twitches from sam-e which also ritalin brought out. sjw feels kind of like a drug like ritalin but with a much lower up. i&#039;ve got to say i feel pretty good taking it. i take 350mg once in the morning, a double dose at 2:00, and a single dose again around 6:00. sometimes i will take another dose around 10:00 p.m. i feel like i don&#039;t need the sam-e anymore. highly recommend."