"i&#039;m 18 years old, and have been taking concerta now since my sophomore/junior year of high school. i was also taking zoloft (for depression) along with my daily dosage of concerta. now that i&#039;m in college, things have been going better for me, and i don&#039;t have to take the zoloft anymore, and only take the concerta when i feel like i really need to focus throughout the day. however, i&#039;ve been noticing recently that while on the concerta, i&#039;m moody, tired, and unmotivated.  i also start thinking really negatively about myself, and find myself very irritable. i feel like i&#039;ve taken several steps back, and should be taking the zoloft in order to balance out my emotions."