"my doctor started me on zoloft for longstanding low-level depression that was increasing due to menopause, and for possible migraine prevention. it did nothing for the migraines, but it has definitely improved my mood. i started on a 50 mg dose and the doctor had me increase it to 100 mg after a few weeks. still no migraine relief, but i the holidays didn&#039;t depress me as they always have since my father passed away. i did notice trouble sleeping, but taking it in the morning instead of at night helps with that. also a slight weight gain. i might try going back to 50 mg if the doctor okays it. it seemed to be enough, and i don&#039;t want to over-medicate."