"i was diagnosed with major depression and anxiety almost 20 years ago. before i was on cymbalta, i was on zoloft for about 8 years and it had the dreaded developed tolerance effect (it gradually stopped working). i was then put on cymbalta, which worked great for about another 8 years. then the break-through symptoms started again, so my doctor suggested i go up (from 60 mg/day) to 90 mg a day. and although this worked great for managing the anger, irritability and anxiety, i completely lost my libido and any ability whatsoever to have an orgasm. i am back down to 70 mg/day and having to augment with buspar. still having anger and irritability, however."