"i switched from loestrin 24 fe to ortho tri-cyclen lo after being on the former for over a year and a half and still not having predictable periods.  ortho has regulated my period, which was miraculous to me, especially since i also have a thyroid condition which makes it even more unpredictable, and i haven&#039;t had any breakthrough bleeding/spotting. one thing i did notice on ortho, however, is a new moodiness i&#039;ve never had before.  i found myself crying over silly things and swinging in and out of depressed states daily, which is very scary to me because i am usually the &#039;guy&#039; in my relationships without the emotional tendencies that most women have.  i just hope it lessens, though, because otherwise this birth control is great."