"recently my doctor changed my breakthrough pain medication to oxycodone 20mg from oxycontin 20mg. immediately i noticed a huge difference, and for the first time in four years felt that my pain controlled. now i&#039;m taking oxycontin 80mg twice daily with oxycodone 20mg every four hours prn.  overall oxycodone provides the quickest and most effective pain control above all oral narcotics i&#039;ve taken. however i do caution long-term users of increases in tolerance, monitoring if ever more medication is needed to achieve the same effect. i first noticed an increase in my tolerance two weeks of taking 4-6 tabs daily. i gradually increased my dose until i was needing double my starting dose. within one month my tolerance increased by two-fold."