"i&#039;ve been taking this medication for major depression for 14 years now.  17 years ago i was given big doses of steroids due to problems resulting from back surgery.  those high doses of steroids pushed me into major depression.  after 3 1/2 years of trying to find a medication that worked for me, i was prescribed anafranil.  within two days i was seeing positive results.  within a year of taking anafranil i was free of depression.  i&#039;ve been taking anafranil ever since - somewhat afraid to stop.  there are many side effects - that i often get tired of - but they pale compared to the relief i received from this medication.  it is the most serotonergic of the tricyclics and i feel should be more widely tried for major depression."