"i am writing this review because most people don&#039;t bother writing reviews when they have a positive experience, and it can sway others not to use depo when many women don&#039;t have issues. i have been on depo consistently for 5 years now, with zero complaints. in the first year i had irregular periods, and stopped having them completely after that. i get about one period per year now, if that. i did not get any acne, but i&#039;ve never had acne problems anyways. i do believe depo causes weight gain, although it could just be because i started taking it at 18 years old (about 120 lbs) and now i&#039;m 23 (145 lbs). i can&#039;t say for sure if it&#039;s the depo, but i have to work out just to stay the same. all around though, i would recommend depo 100%!"