"i have suffered from depression for about 30 years.. crippling depression with anxiety since 1992.  i am 62.  i have taken nearly every antidepressant and none really worked.  i read this forum about four months ago and decided to order 5-mthf,10 mg.  after about three weeks, i realized i was coming up from the deep depression.  i was taking 20 mg of lexapro and cut that down to 10 mg a day.  i am excited that this might be what i need but will wait a while before foregoing with the lexapro because i&#039;m not ready to enter that deep depression if this doesn&#039;t work by itself.  i am so excited even if i do have to continue the lexapro.  to feel like getting out of bed, doing normal things and feeling good is great.  i will post updates."