"i have severe depression and anxiety. tried one other anti-depressant with disastrous results.  changed doctors and changed to pristiq. wow! i could tell the difference within the week.  six weeks later i feel wonderful, now i realize how depressed i really was. no major side effects, a little headache occasionally, but nothing compared to life without pristiq.  everything is clearer, calmer, and i am coping really well.  it makes therapy more effective.  life is great."