"i have been on pristiq for a half a year now. i started on 50mg and quickly worked my way up to 100mg. i take it specifically for anxiety. aside from general anxiety disorder i have bipolar and so i take other drugs such as lamictal, lithium, and latuda to help with depression.  with pristiq i don&#039;t experience much in the way of side effects. my doctor told me to watch out for fatigue, as it is a common side effect, but i was tired even before starting pristiq so i can&#039;t comment on that. recently i read about grinding teeth as an effect and finally i was able to explain why i have been doing that every day. but that&#039;s it for me. it has helped a lot with anxiety. occasionally, however, i do have bouts. i don&#039;t think anything&#039;s full proof."