"started this medication exactly 1 week ago and i&#039;m down 7.4 lbs (237.6 down to 230.2). i was given the 37.5 mg pills but have only been taking half. my doc told me to take 1/2 pill as long as i could if it was still working for me. it has 100% curbed my appetite. i literally have no urge to eat which is so unlike me! and when i do eat i am full so much sooner. i am drinking a ton of water with it. first 2 nights i had a lot of trouble sleeping but i learned to take my pill before 8am and i&#039;d be fine. i have had constipation which still hasn&#039;t really resolved but i&#039;m just going to increase my water and hope that improves. will keep posting with my weekly progress!"