"i have been on cymbalta 120mg for three years now and still feel no difference. i suffer from major depression and anxiety. it has done nothing for my illness. my psychiatrist also has me on wellbutrin 150mg and abilify which i guess is supposed to jump start the antidepressant but so far since being on it i have been to cpep two times which is a mental ward at the hospital. 
 and common i read where some have felt a difrence in 48 hours or a week that is bull. 
 finally my pdoc is going to put me on maoi&#039;s as i have been on so many of the new antidepressants for the past 10 years &amp; nothing has worked but cymbalta is no miracle drug."