"my last medication velafaxine stopped working thank god! i was on it for four months and in that time i gained more than fifty lbs. seasonal depression, dry mouth, unsociable, and had no interest. i started bupropion hcl tabs to 150 and had a few side affects. the one that was so hard has stayed is restless sleep that wakes me up really early. dry mouth, shaking in the morning, constipation, drowsiness and i expect these should go away. but sleeping will be the hardest. i feel happy, doing projects, want to be with people, energetic, i&#039;m back to charity running. and the weight is starting to come off. i was close to eating nothing with the other med. give this a try. gave my life back."