"my six-year-old grand daughter has been on intuniv for nearly two weeks. she has asperberger&#039;s syndrome and adhd. so far i have seen no improvement, but still hold out hope. what i have seen to date is extreme tiredness and irritability. she has always been an excellent sleeper, but now goes to sleep around 9:00pm only to awaken at 4:01am (with only three minutes variance on either side) and unable to return to sleep until around 6:00am. then awakens at 7:00am irritable and confrontational. she has developed circles under her eyes and is exhausted for the entire day. she is also on ability --  2.5mg per day (down from the 5mg she was taking prior to beginning the intuniv."