"past experience taking medicines that did work (celexa, wellbutrin), 1-2 years later they seemed to stop working (weepy, sad, never wanted to get out of bed, no desire to do anything, flash backs of a traumatic event, constantly dwelling on negative past experiences, etc.). 10mg brintellix prescribed (1/10/14) while weaning off wellbutrin. not so weepy, but was still sad, had no motivation to get out of bed or do anything. increase to 20 mg (1/28/14), felt like i was going &quot;downhill&quot; fast: even sadder and weepier, etc. told it may have been too much at once, so was told to take 1/2 dose one day, full dose the next (2/15/14). still not feeling as well as i thought i should. increase to 20 mg blood pressure went up from 110/68 to 124/72."