"this has seriously been my miracle. after trying 5  different ssris with horrible side effects, remeron literally saved my life. i was given it during a hospital stay (i was suicidal). the only side effects i&#039;ve experienced were sleepiness (in the first few weeks) and increased appetite (ongoing). personally, my depression caused me to have no appetite at all, so the increased appetite was a welcome effect, although it may not be for others. i can sleep, i can eat, and - most importantly - i can live. i can get out of bed in the morning and live my life. i am on 45 mg once a day (at night). with this medication, in combination with cbt and mindfulness meditation, my depression is almost completely gone."