"my experience on saphris has been mixed. none of the other atypical antipsychotics has addressed my manic symptoms better. it really helps with my sleep. my moods are more stabler, i&#039;m less of a trouble/burden for my family, and i&#039;m happier than i&#039;ve been in the past. now the problems: first, when i&#039;m on saphris, it lowers my sex and creative drives. i&#039;ve had trouble in bed, and i&#039;ve found it really difficult to generate new ideas for paintings and drawings, and the quality of my art overall has decreased. second, saphris appears to be impacting my long-term memory. my spouse has noticed this. i&#039;m just not remembering my past with reliability--memories are faint and/or scrambled and i usually get details and dates wrong."