"i lost medical coverage 1 1/2 years ago and had to quit my sertraline. remember folks, all of our chemistries are different, so different anti-depressants will work for some but not others-you have to keep searching for what works for you. i tried prozac, lithium and wellbutrin-all made me feel worse. but sertraline works for me. the only thing is, like many things, it loses its effect after prolonged use. so i am about to get back on it after almost 2 years of non-treatment. i am looking forward to the results again which will last 2-3 years then dry out again, and start again. another vicious cycle included in depression ..."