"i&#039;ve been on adderall since i was in high school, so about 5 years. it works well for my concentration and allows me to focus for an extended period of time, such as when studying. this medicine has definitely helped me but it has a lot of side effects. for me, loss of appetite, euphoria, and dry mouth is the most common. headaches are frequent, but nothing ibuprofen can&#039;t fix. i&#039;ve been on/off antidepressants that affected the adderall. when i was on lexapro, taking adderall would make me irritable, anxious, and paranoid. sometimes to a full blown panic attack. now i&#039;m on prozac and the adderall combination is fine. but i still get anxious and mildly irritable when the &quot;high&quot; of the adderall decreases."