"wow, this stuff is amazing!  it did not work at first, but my sister, who is a nurse, told me, that because i had gastric bypass, that i probably need to take more than the 15 mg because gastric bypass patients do not absorb nutrients very well at all and need supplements. i am now taking 45 mg per day without any side effects. and the negative thinking has all but disappeared. i had a dna test done as my new psychiatric nurse practitioner, after having listened to my woes of having no success with meds or ect immediately insisted that i take the dna test.  as she suspected, i have not one but two mutations on my mthfr gene, which decreases my ability to process folic acid in a big way.  she suggested that i try  inositol/choline too."