"six months ago i (57 yr male) was severely depressed, difficult to think, difficult to move.  my doctor put me on 40 mg fluoxetine daily, with 0.5 mg clonazepam for the first 30 days.  after five days i felt the drugs were overwhelming.  i was having a lot of anxiety with hypertension and tachycardia and felt really out of it.  i cut the dosage in half (taking the fluoxetine every other day).  by about four weeks in i was doing much better, able to think and move again.  about four months in, however, i started getting the blood pressure spikes and rapid heartbeat again and just generally felt overstimulated, so i asked my doctor for the 20 mg size, and he agreed i could take it once every other day if daily was too much.  this has worked "