"i been on topiramate 25mg once in the morning and once at night  been taking it for four days now with no changes in appetite at all. i am at the same weight. i am taking it for the side effect to lose weight, but i do suffer from depression. i will update you all if any weight loss does occur. i will be going to see if my primary care doctor will prescribe me the new weight loss pill qsymia next, because it has topiramate in it. i just need a jump start to getting this weight off of me. i have been reading accounts where people have been losing off of 50mg of topiramate, but not for me hoping maybe in a week i may see results. i have a 30 day supply. let&#039;s hope"