"i was prescribed imipramine for depression. it worked very well for years! but... it made me a diabetic with peripheral neuropathy. when i was originally given the medication i was told it would increase my appetite. it did - a lot! it also raised my glucose levels to astronomical levels (400-500). my a1c was between 10 and 11. over time, it damaged my nerves. i didn&#039;t realize this until my feet began to burn. after slowly decreasing imipramine by 5 mg per week until completely coming off it, my feet were unbearable. the pain was constant. i couldn&#039;t walk, or have anything on my feet. i would sleep with my blankets folded up and my feet hanging off the bed. i would soak my feet in ice water to alleviate the burning and pain."