"i&#039;m day 4 on pristiq.  i&#039;ve always hated being medicated to treat my depression and anxiety, for some time i had been doing okay with managing it on my own but recent events in my life sent me for a downward spin so i had to start the medicine. the first day was awful, i was dizzy, nauseated, shaky and for a period of 2 hours i was hit with a serious wave of paranoia i&#039;ve never felt before. i wasn&#039;t keen to keep taking it after that but i&#039;ve stuck it out. my doctor had to give me a sedative to help level me out because i was going up and down, mood completely unpredictable.  today is the first day i&#039;ve taken the sedative with pristiq, so far so good. i&#039;ve had to be on leave from work until things are a bit more balanced."