"i have been battling bipolar the majority of my life. at one point i was on 8 different medications: lamictal, depakote, seroquel, elavil, neurontin, propranolol, a couple i can&#039;t think of.  my most recent doctor got me down to 3, the main one being lithium. i began latuda on 20mg for a week and now i&#039;m on my 4th day at 40mg. today is my second day with adverse side effects...extreme nausea, loss of appetite and diarrhea.  i trust this will pass as it did the first few weeks with lithium.  i have to say that i&#039;m loving the med otherwise. i&#039;m quicker to smile and slower to anger...i nearly feel in control.  make sure you take with food and expect to be less than 100% for a couple of weeks."