"i developed an illness that evolved in stages.  a few stages in i lost the ability to sleep naturally.  this was about eleven years ago.   a few years went by trying every sleep med with utter failure.  ambien, lunesta, benzodiazepines, trazadone, most atypical antipsychotics.  eventually a new lifestyle evolved where i would be up for near three days straight then sleep for a full day, repeat.  what finally put me to sleep was a little risperidone and a megadose of seroquel.  risperdal &quot;allowed&quot; me to fall asleep, while max dose of seroquel &quot;kept me in sleeping state &quot;long enough&quot; and &quot;deep enough.&quot;  3am now, tried 10mg of zyprexa an hour ago alone, its barely affecting me. remeron with halved seroquel/risperdal, put me down great."