"i am extremely sensitive to medications and any chemical. i get headaches from the chlorine in tap water. i was afraid to take even the lowest dose of cymbalta, but i swear i felt happier, more talkative, and much less obsessive and less negative within the first day of taking it. by the third day i noticed that i got a little tired about 1-2 hours after taking it, but i was still pleasant to be around and nice to others. i think this is also helping with some pain i&#039;ve had from a shoulder injury a while back, so that&#039;s good too. my mother also takes this for fibromyalgia and she loves it. good luck!"