"my rx 5/325. i had bilateral total knee replacement 12 weeks ago. taking this totally helped me make it through this recovery period so far. i now take less than one a day and try to use ibuprofen instead.  my side-effects did not outweigh the benefits, but as you can see from reading the reviews, everyone has a different reaction. mine are: constipation, so i took a laxative or suppository, slow reaction time, be extremely careful if you have to drive, if you can avoid driving, impaired/cloudy thinking, restlessness. when i go back to my desk job, i can take this during the day, but if you take at night, you may not sleep well. i plan to continue to taper off and use only when pain level above 5. ibuprofen nighttime works better for sleep."