"this is an anti inflammatory.  if you have a serious inflammatory response in your system, this will take time to reduce your pain. it is not like oral pain relievers with near immediate results. patience is needed. if you&#039;re having trouble with it adhering to the skin, make sure the area is free from oils, either naturally or lotions or soap residue. i have no problems at all with them. my ra flared up in addition to my cocyx broken off, literally.  the pain  was so severe that oral meds weren&#039;t effective. it took several days to feel the beginning of relief, and i&#039;ve improved steadily. if you&#039;ve used these short term and are the impatient type, chill out and give them a chance. they do work."