"i&#039;ve only been on seroquel xr for 5 days, so it&#039;s hard to tell long term side effects. it definitely makes me calmer and allows me to handle difficult or stressful situations more appropriately (not crying at the drop of a hat or feeling extreme anxiety). i am only on 50 mg at bedtime, but i&#039;m not completely 100% so hoping to increase that dose a bit when i see my doc next. i do get headaches and have lost my appetite (still haven&#039;t lost any weight though). i am hoping for the best!"