"if you are scrolling through 1000&#039;s of reviews like i was, this one is for you. i started zoloft three weeks ago for major depression and overwhelming anxiety and panic attacks. i started at 25mg for a week, then up to 50mg. initially, i felt a million times worse, constant panic attacks, increase in suicidal intrusive thoughts, deep depression. but, after just 1 week at 50mg, i noticed a difference in mood, and it&#039;s been better and better since. fight through the initial worsening of symptoms if you can! i asked for xanax to help me get through it. it definitely gets worse before it gets better for some people, but it was 100% worth it for me! i also had slight nausea, a sore neck, and some dizziness that all seem to be subsiding."