"started seroquel at night combined with effexor during the day for bipolar and it&#039;s changing my life and saving my marriage. where i used to have one good day a week, i have one bad day a week. upped from 50mgs to 100mgs because it&#039;s effectiveness wore off mid day and recently added topamax because i&#039;ve been attempting to lose weight (i have not gained, but it&#039;s harder to lose)."