"took it for about 2 years - get ready for weight gain, loss of interest in everything, extreme tiredness, zero interest in sex. sure, my &quot;depression&quot; symptoms felt a little better (but would have had at least the same result with healthy diet and exercise). it took the &quot;bad feelings&quot; away, but it also took the &quot;good feelings&quot; away. when i weened off pristiq, every five seconds i felt like an electric shock in my brain (that&#039;s the best i can describe the feel) it was the worst 2-3 weeks of my life."