"i have been on opana about three weeks now for severe, chronic pain. i used to be on 60mg of oxy-contin and i took the first dose prior to getting ready to leave for work, after that i would spend the next 10-20 minutes vomiting. opana doesn&#039;t do that to me in a 20mg dose and i find the pain relief much more lasting and comfortable.  the only medicine i ever took better than opana for chronic pain relief was the once a day ,now defunct pallodan."