"i have been trying both 300mg and 150 mg. daily doses in combination with 20 mg lexapro for several years now.  i was not doing well on lexapro alone, still too mopey and negative.  i am finally doing much better and feel strong enough to let go of the lexapro and try budeprion alone.  after just a few days i feel totally different and much better.  it is very energizing, i feel positive and am getting a lot done.  my libido is coming back and the sexual side effects from the lexapro are gone too.  300mg per day may be too high for me, i feel almost manic.  i may try (with my psychiatrist&#039;s support) to stay on 150mg but so far this medicine alone is working extremely well for me."