"i had two injections of depo-provera when i was 25. the first shot was fine, no abnormal physical side effects, maybe a little spotting during what should have been my menstrual cycle. then about a month after the 2nd shot i cascaded into a deep depression that involved suicidal thoughts. my libido was also gone and it took over a year after the 2nd and final injection to feel better in terms of the depression.  my libido never recovered. i am now 45. my last sexual encounter was when i was 32. i firmly believe that depo-provera is responsible.  but hey, bright side, right? i didn&#039;t get pregnant :/"