"i am 26, female and have been on pristiq for a little over 18 months. it worked fantastic for the first year, my anxiety and depression was under control for the first time ever. for the last few months though i have noticed a lot more side effects, i have gained weight and although my sex drive hasn&#039;t dropped i find it very hard to reach orgasm. also if i miss one day i have really bad withdrawals - migraine headaches, nausea, dizzy spells and out of control emotions. i think pristiq is great for short term use but i&#039;m not convinced its good as a long term option."