"i have tried zoloft and cymbalta. all equally effective in my anxiety level but i find effexor has been the best. while i still don&#039;t have a ton of energy, i was a zombie on the other two. my libido is back to normal and i&#039;m not hungry 24/7. zoloft would be my second choice, except i needed to nap everyday and i was always hungry. cymbalta was very difficult to get off of and i was also very tired. negative effects of effexor include  insomnia - i have urges where i have to get up- but usually melatonin and reading, and no electronics before bed help that (or xanax as needed.) i also sweat a lot more on it. but having more energy and more libido make it worth it. i have to take a beta blocker because i speak infront of people."