"i see a lot of negative reviews on here of people who have only just started the medication.. all i can say is that you need to actually be on it for more than 2 weeks to even begin to be able to judge it. i&#039;ve been on mirtazapine 45mg for about 8 months and i find it to be great an enhancing energy, motivation, creativity and social behaviour. there is no depression anymore whatsoever. the only negative thing is perhaps i am a bit emotionally blunted, but that is a fair trade off."