"it takes about 2 hours to start working, so it&#039;s definitely a long-acting medication.  it says it lasts for 12 hours but it only lasts 7 for me, every time, without fail.  i cannot just take the zohydro er but i need to take my rescue medication else be miserable for 2 hours before it works.



it gives you constipation sometimes, even if you drink a ton of water.



it seems to be weak pain relief.  i wish it could work better and last longer.   my doctor is switching me to a different er pain medication now."