"my experience with the depo shot was horrible. i started off the first year on the pill and it was okay but it wasn&#039;t helping my bleeding at all and i was tired of taking the pill every day. i started the shot in september and the first two months were fine, i didn&#039;t bleed at all but when i tell you i had major mood swings it was terrifying. i would be depressed or really angry for about a week until it calmed down a little. i took the second shot thinking my body would start getting used to it and balancing everything out and the same thing happened again but i started to get more stomach pains and migraines. now i just found out i have a tumor behind my eye! thanks a lot depo"