"i am taking 150 mg. i began at 75 with little effects. at 150..honestly i feel more anxious, yet medicated. i have been taking effexor for 6 months.i  believe it does more for my depression, than for anxiety. my appetite is about the same. i seem to wake up irritated, and have to take seroquel at night to sleep. i am going to give it a few more months, then will talk to my doctor about changing it, or adding something for anxiety."