"has many years of  problems with depression, anxiety , derealization etc. eventually learned these all related to complex multiple trauma. but that is another story. doxepin pretty much the only antidepressant that has ever helped me. totally a life saver over and over for me. 



it is highly calming as well as anti-deprssing. that is because  simultaneous to increasing serotonin and norepinephrine,  is a beta adrenergic blocker (hence anti fear etc)



but here is the real amazing thing about doxepin - it is very anti- inflammatory. neuroinflammation (brain inflammation) is a big issue  in mental health problems. doxepin - out if all dregs, addresses this best of all. search pub med. doxepin has saved my life many times over several decades."