"pain doc just switched me to nucynta er 150 mg - twice daily...after making the rounds of other meds. i was on 4mg dilaudid before this - morphine, oxycodone - all losing some of their effect after a while; but, they all worked better than this tapentadol stuff. i am a cancer survivor with a host of other conditions - arthritis, carpal tunnel, cervical neuropathy and lower back pain. not only is it having no effect on the pain - i can&#039;t sleep - have pounding headache and now can&#039;t urinate at all (enlarged prostate). don&#039;t like this med at all..."