"i have bipolar i with severe depressive episodes lasting up to 16 months. zoloft was a last ditch effort to improve my depression; i was formerly on luvox and found it too sedating and less effective after being on it for over a decade. so far, i have had 15 days without severe depression after being on zoloft for one month. i think it&#039;s working. i am tired but i am not sure if that is the zoloft or something else as i am on several medications for psychiatric problems."