"i&#039;m a 30 yr old male.  i was on zoloft for 5 years (gained 40lbs, couldn&#039;t ejaculate) then cymbalta (nasty side effects). for a couple months my psych doctor let me try pristiq.  i loved it. i had/have awful anxiety and panic attacks with depression. (my anxiety is because of my depression). this medicine worked quick and i&#039;m now in my 7th month at 50mg once a day.  the last week, it seemed to dwindle down a little (not sure why?), as my depression and anxiety started coming back.  my same doctor just upped my dosage to 100mg a day.  i&#039;m hoping it wont let me down! i have to say that pristiq is the best of 3 anti-depressants/anxiety medicines i have tried. thanks all and good luck."