"i have been on brintellix about 4 weeks. 2 weeks on 5 mg and 2 weeks on 10mg.  i have been on numerous antidepressants for depression and anxiety.  this has been so far the best.  a little nauseous after taking it the first week and a half. nausea went away after eating something.  no side effects after second week.  no weight gain so far.  feel better everyday."