"i was on pristiq at 100 mg for several years;  i was happy and positive, free from anxiety and depression.  earlier this year i made the mistake of tapering and discontinuing the med d/t feeling dependent and sexual side effects.  i ended up having difficulty w/ memory and would cry at everything.  i have tried to go back on and after 12 weeks i&#039;ve made improvements but no where near where i felt before...i function but i have difficulty sleeping, have crying spells, and feel terribly depressed especially in the am.   i&#039;m going to now try lexapro since it worked for a close relative; hoping it helps me turn the corner.  if you&#039;re on pristiq and it&#039;s working, don&#039;t stop!  discontinuing this med was a big mistake for me."