"so far so good with the hysingla er 20mg 1x per day. i was on 4-10/325 loratabs per day. my doctor recently put me on hysingla with 2-10/325 loratabs for break through pain. i have been on it for 3 days and i can already tell you that it has an amazing effect on my pain. it is not totally gone and i know it never will but it has helped so much! i have spinal stenosis and a few disk problems along with nerve problems! i highly suggest trying this!!"