"i have mixed bipolar symptoms and was increasing on the monic side. 1 clonidine and in 15 minutes i had some relief and felt nearly normal. i like that it is an as needed drug and i don&#039;t have to take it everyday like my other medicines. the only drawback is that it only lasts 4-6 hours and you have to take it again but to feel nearly &quot;normal&quot; i will do that."