"i suffer from interstitial cystitis and have tried all the medications to keep the burning pain and heaviness in my bladder tolerable. i was given amitriptylene first (5mg.) and i was like a zombie the entire next day. i tried it a few times to give it a chance but without any change. a specialist that i saw a couple of months suggested that i try nortriptylene because even though it is in the same family as amitriptylene sometimes it has a different effect. i have taken it for 4 nights now and have noticed a huge difference in the way my bladder feels. spasms are gone and the heaviness and burning have gone as well. i haven&#039;t slept well since taking it but was having trouble sleeping through the night anyway. no day grogginess though."