"my depression is clinical but was triggered this time by traumatic events in my family including my father&#039;s diagnosis of brain cancer.  zoloft has worked for me in the past so i decided to try it again.  the difference is almost immediate and the only side effects are some fatigue. i take 100 mg once daily (i weigh 118 lbs).  i also suffer from panic disorder which had gone into remission but reared its ugly head when my depression re-emerged.  i take klonopon twice daily.  i have not had a panic attack since starting both of these medicines, and other than feeling a little tired, i am coping with life again."