"i am only on day two. i hesitated taking this drug because the last antidepressant i took (cymbalta). was horrible. it took me a year to get rid of the withdrawal symptoms. to this day i will still have random &quot;brain zaps&quot;. so back to the brintellix, i was in the deepest and darkest depression of my life ever. i knew i had to do something so yesterday i took my first pill. later that evening i was feeling much more calm and better. today my deep depression is gone. i still have room for improvement. i would have never thought in a million years it would start to work that fast. i was very nauseous yesterday after i took it but i was nauseous before i took it.  i just took pill #2. so far i am very impressed. i will report back in the future"