"i on klonopin 2mg 3xdaily, for many yrs. i don&#039;t know if others have experienced the same thing or not. but, i felt i, either had been on it so long it lost some of it&#039;s effectiveness, or my anxiety and panic attacks got worse due to a tragedy. but i switched to clorazepate and i cannot believe how much better i feel. i took it before, yrs ago, for a couple of months, and i do urge you not to start out on an extreme high dose, until you know how it works for you, and if you need to increase it, you can. a true lifesaver for me. good luck to you others out there."