"i have had insomnia off on and for 20 years and have been depressed for at least ten and have insomnia and anxiety. my doctor thought i was bipolar initially but has seen my problems concurrent, and we have dismissed mania. doxepin works great. i was on seroquel with many side effects, but i take 200mg of doxepin in two doses, and i take klonopin, 1mg 3 times daily. i am a recovered drug addict and am very careful about abusable substances. this combination is perfect for people like me. the only side effect i have experienced is weight gain. in the first 3 months i began taking doxepin, i gained over 50 pounds but after several months my weight plateaued and is coming off with moderate exercise."