"i have major depression....was taking prozac 40 mg a day and it just stopped working for me. i have started effexor xr 150 mg twice a day with some sleeping pills at night....in such a short amount of time i feel so much better! life changing better! depression is horrible and all consuming and pray that every person trying to get help does....and at least for me i have found stimulants of any kind are not good....because the crash or comedown is more than i can handle with my underlying depression."