"started phentermine march 2016 37.5 mg. one x a day.  as of april 15 no change in weight with change in eating pattern of reduction in amounts.  started the topiramate as a mood stabilizer late march 25 mg titrating to 100 mg daily. so the combination of the two together for the two weeks the 37.5/100 has seen no weight loss effect.  very disappointed.   had read good things about the topiramate alone and then about the combination of the phentermine topiramate.   i eat almost no sugar, do not drink pop, eat red meat, or consume outlandish amount of calories.  the weight should be falling off."