"50 mg (2 every 6 hrs) has worked wonders on my pain. i have a small cerebral aneurysm (too small for surgery yet) that causes me to have a terrible ongoing headache (for almost 3 yrs now). if taken consistently, it keeps my pain very manageable. i weaned myself off of antidepressents when i was in my 20&#039;s (i&#039;m now 37) but depression crept back up on me. when i started taking ultram, the depression symptoms went away. i do have terrible withdrawals though. otherwise, its been a lifesaver for me! thumbs up!"