"i have struggled with depression and anxiety for some time, now. i was initially worried that the stimulating effects would exacerbate my anxiety, and it did--but only temporarily. wellbutrin xl 300mg has been the only antidepressant that has worked. i take it in combination with effexor xr 75mg. i was taken off wellbutrin in an attempt to switch to effexor only, but it became quickly apparent that wellbutrin controlled most of the depressive symptoms. i stopped it for 2 months--both of which were awful. within a week of resuming wellbutrin, my depression began to lift. i still have bad days, of course, but the effects of wellbutrin make me more energized and ready to take on the world."