"i&#039;ve been sort of depressed or slightly anxious always. started 50 mg sertraline daily 6 years ago. great from the start, the only negative effects i ever experienced were from not taking it sometimes. it leveled out a few years ago and it probably needs to be upped by 25 mg daily. it has worked many wonders for me but i need to really chill out a little bit more, maybe this will do it."