"i&#039;ve been taking 10mg dose for about seven months. what i noticed initially is that my sense of smell and hearing seemed sharper (weird). also, no longer entertaining thoughts of suicide. i took zoloft for almost two years about ten years ago and i like brintellix better. i did have nausea and constipation at first. now, i still have some weepy times and times when i just feel like giving up (i am a widow of three years), but i also have times of joy and happiness. mostly, i feel content. i have a sense of humor again. sometimes i forget to take the medicine for two to three days and i feel my mood deteriorating, but i don&#039;t feel the weird physical effects that i had if i forgot even one dose of the zoloft."