"i have been on pristiq for about a year now, i have depression, and rage disorder, i have been a lot better but recently i am starting to feel as though i just don&#039;t care to go on. i am not sure if i am developing a tolerance to the drug but i am starting to worry about getting the blues completely back. i had an episode recently where i went straight to rage, no being upset or mad, just straight to aggression. i yelled and screamed but did not hurt anyone. i have not felt like this since before pristiq. i am only posting this to warn of what may be down the road for some. i have an appointment with my doctor to see what is next. just when i thought this was over."