"psychiatrist put me on brintellix about 7 weeks ago. 10mg for the first 3 weeks - which had no effect on my depression, but i didn&#039;t notice any side effects like i had with pristiq, lexapro, lovan &amp; alprazolam. the dosage was upped to 20mg for the next 4 weeks. still feel terrible, haven&#039;t noticed any shift in the depression but i&#039;ve noticed i feel a bit more edgy and anxious. not sure how long i&#039;m meant to wait to notice a change but i&#039;m not convinced that this drug is working for me. it&#039;s also not covered by medicare in australia, so quite expensive!"