"i was on minocycline for about 3 years for acne. it controlled the acne great. then one day out of the blue various joints were extremely swollen; maybe two of my knuckles, one of my toes, and my knees. i could hardly walk it hurt so bad. the next day that swelling would be gone but other joints would be swollen and stiff. i tried the process of elimination, cutting certain foods out of my diet, various vitamins. i went to the doctor and they were baffled. i finally stopped taking the minocycline. in 24 hours swelling went down. 2 weeks later i took one pill, within an hour my joints swelled. i&#039;d developed an allergy to it."