"out of the vast amounts of different medicines i&#039;ve taken over the years (most of which has been medicines prescribed by my physicians for severe pain, insomnia, and other chronic issues), this otc medication is the very best for a number of conditions. i&#039;ve had migraines for most of my life, but am allergic to prescription drugs for migraines. i&#039;ve found that percogesic is ideal for many problems. i have always had a high tolerance for medicines which could sedate a large farm animal, yet it is next to impossible to sedate me. percogesic, however, has sedative properties, unlike so-called &quot;migraine&quot; medicines, like excedrin migraine. the active ingredient in excedrin is caffeine, which is the last thing i want when i&#039;m trying to escape pain."