"i&#039;ve been taking spiro 50 mg. for 6 months for acne &amp; i&#039;m thrilled.  i&#039;m 45 and have had problems with acne (mainly on chin) for a decade. dr. told me it would take 6 weeks to start working.  what he didn&#039;t mention is that it might get worse first.  3 weeks in, i wanted to bury my head in the sand.  (so i wouldn&#039;t start it right before a major event!).  at 6 weeks, it was helping but still not great.  dr. suggested we go to 100 mg but i wanted to give the 50 mg a chance.  by 8-9 weeks it was great!  i still occasionally get a pimple but it&#039;s small and doesn&#039;t last long (unlike the large painful cysts i used to get!)  note:  generic:  mutual pharm.  when pharmacy switched to qualitest, i started breaking out again...but they changed back! :)"