"i have been off depot for almost 6 year so and i have several side effects from this shot that don&#039;t think will ever go away. it has really messed me up in don&#039;t know if anyone has the same issues i get severe migraines monthly and a rash that itches like no other where the injected the shot in my butt every month right before my period starts. it&#039;s really annoying. i am wondering if anybody else is experiencing the same kinds of things that i am. i have a lot of pain in my hands i get tingling in my hands and my feet."