"i am coming off seroquel xr because of a 20 pound weight gain in 3 months. now starting saphris 5mg now on 10mg then going to 20mg. i have tried all kinds of medicines to stop cycling and stop my depression. i never thought i would get out of the hole i was until now. i have more energy and sleep great and wake up wide awake ready to go. hate the taste. do have more of an appetite so since i&#039;m eating the weight should come off because before i was not eating at all. i pray this keeps working awesome."