"opana is the most effective of all the opiates i have taken for my osteoarthritis. what used to make my life a living hell is now under control. that&#039;s not to say that i don&#039;t have bad days, but compared to all the other meds i&#039;ve been prescribed, opana definitely ranks #1. it took a few weeks for me to feel a positive effect, but i&#039;m glad i suck with it. it&#039;s the best."