"after 3  years of a dark depression, i hit bottom and started wellbutrin 300mg every day. over the next 2 years, i&#039;ve lost weight (because i was trying), i quit smoking (because i wanted to) and i discovered a small part of life that was tolerable (a small part). i increased to 400mg in july because i felt myself slipping back to the dark place and it&#039;s the first time i&#039;ve noticed side effects: marked insomnia, unfavorable irritability, a little bit of numbness, i crave sweets and i don&#039;t seem to want sex as much. so i&#039;m thinking 300mg was the therapeutic dose for me and will call my doctor to see what the plan is. on the bright side of the 400mg, i&#039;m sitting here tonight writing a positive review for the medicine i believe in."