"like others have posted nefazodone (as serzone then) saved me when traditional ssri&#039;s made me even more anxious. the fog of depression i was walking around in started to lift in a couple of months. it was 10 years ago. i think i was taking bupropion in the day and trazodone for sleep. but it was the nefazodone that snapped me out of it. took if for a year almost to the day at which point i didn&#039;t need it anymore (i had already stopped taking the other two). the only side effect was early on and it went away after a month: after urinating i felt like i still needed to go. like another poster, i felt cured. 10 years later, financial and work stress have taken me down again. i started nefazodone &amp; bupropion again. too soon to tell..."