"when i started vortioxetine i had severe esophagus pain and severe ear pain. i thought i was having a heart attack. i nearly went to emerg. i had attacks like this for about 2 months. i also had indigestion and i never get that and i threw up a few times. i had headaches for a few months which i normally don&#039;t get. however; though i had all this physical discomfort, my mood improved and i started socializing again. along with an improvement in mood, my cognition improved and my concentration as well. i don&#039;t believe any drug is going to solve life&#039;s difficulties but vortioxetine is definitely helping out"