"i am diagnosed bipolar i. i take trileptal and have switched antidepressants several times. i have tried lexapro, zoloft and prozac. all having relative success with my moods, but loss of libido forced me to switch. pristiq has been the best i have tried. both my moods and anxiety have improved. still less of a libido than without any medication, but better than any of the other antidepressants i have taken. i still have a faint libido, but now experience delayed orgasm. however, the quality of my moods has improved so much that i am more apt to accept this side effect."