"lots of nausea after moving from 5mg to 10mg. days and days of headache and nausea, did get a zofran rx and i feel much better! i believe this med is doing a good job at helping with my depression and anxiety. just came off of prozac after 10 years and i&#039;m pretty happy with the results of trintellix so far, 3 weeks in!  had to work the much hated job at work today - front desk.....easiest day i&#039;ve had up front in years, i believe due to new trintellix....very promising!"