"i&#039;ve been on 75/mg of sertraline (generic version of zoloft) for 5 years.  it has helped a great deal with my depression, anxiety, and compulsive negative thoughts.  i&#039;ve gotten off of it twice; i find that i don&#039;t have withdrawal symptoms if i go off it gradually.  the side effects i&#039;ve had are a decrease in sex drive (which comes back once i stop taking it) and a general feeling of apathy.  it doesn&#039;t make me happy, it just makes me not so sad and much less obsessive.  i do, however, feel i have lost a lot of creativity and motivation.  other than the apathy and lack of a sex drive, it works extremely well at stopping the depression and anxiety."