"i started taking hysingla 40 mg about 10 days ago. it does take the pain away about 80% of the time. i wake up thru the night with only about 3 hours sleep.  i also have terrible headaches now. i don&#039;t know if any of this is related to my medication as i checked the side effects, but this has only started since then.  you would think taking pain medication i wouldn&#039;t have headaches. talking to my pain management dr next week."