"two years on depo... i have been combatting depression, fatigue, and vaginal dryness since my third shot hoping that i could overcome them or being in denial that is was from the shot, but it&#039;s definitely a side effect of the birth control. though the shot is convenient, with no periods and strong hair and nails, i totally feel like i&#039;ve been through menopause and am an old lady with no sex drive. switching to the patch in december, wish me luck."