"i have bi-polar and have been on latuda for 3 days. until reading your post, i was going to take myself off.  the irritability is through the roof and right now i am in my manic mode, getting up everyday at 4:00, so lack of sleep doesn&#039;t help.  my thoughts are foggy.  but i am giving this medicine 2 weeks, i should know by then. latuda replaced the risperdal, i am on 1500 lithium, klonopin, prozac, and vyvanse.  so i hope to feel as good as all of you.  thanks for your experiences."