"i was on sertraline for around one and a half years, with a maximum dose of 150mg.  it definitely did work in treating the depression. it leveled me out. i felt less fragile. it&#039;s difficult to describe, but if depression is an empty, hollow feeling, sertraline filled that up. there was no more of the constant sadness i had experienced before. 
the downsides were: blunted emotions. it became difficult to cry, and i didn&#039;t &quot;feel&quot; laughter. altered sleeping. my dreams were more vivid and i occasionally woke up with my heart pounding. sexual side-effects. sensitive areas were numbed (not totally) and orgasm became difficult. unpleasant withdrawal. dizziness, nausea."