"i&#039;ve only been on sertraline for just over a week and i&#039;ve noticed a massive difference already,  i&#039;ve been suffering with major pmt and depression for a long time but after trying a number of antidepressants and each one making me feel so ill to continue taking them i&#039;ve stopped and tried just buying herbal tablets but they don&#039;t really do alot so after feeling so ill and nearly losing everything i went back to the doctors and was put in these, i was told to take 50mg once a day but after taking them for the first 2 days i felt absolutely awful so i just take half a tablet  each night, i feel a million times better already, it&#039;s my 10th day now and i and my husband and children can see a huge difference in my mood already ."