"i&#039;ve only been on latuda for a week, what a difference it has made in my mood. it has lifted the depression &amp; debilitating anxiety. i take it along with depakote &amp; klonopin (both of which i&#039;ve been on for many years). i take it at night because it makes me sleepy. it does give me a &quot;lump in the throat&quot; sensation, for some reason, about an hour and 1/2 after i take it and that feeling lasts about 2-3 hours.  the next day it&#039;s gone.  i will talk with my psych pa about it, to see what it may be.  i haven&#039;t had this much motivation in a very long time, and it&#039;s not a manic or hypomanic feeling, i just feel like living again.  i hope it continues to work well and doesn&#039;t cause any intolerable side effects."