"zoloft is amazing. i was put on lexapro when i was about 18, gained about 20 lbs and felt like a numb zombie for about a year. tried celexa for about a year- a little better, but i was still getting very depressed. then i tried zoloft (50mg for a month and 100mg since). i&#039;ve been on it for about 2 years. depression and anxiety is minimal. i rarely have to use my xanax. the only side effect i&#039;ve had is dry mouth but it&#039;s minimal at worst. my appetite and sleep patterns are normal. as with the others i&#039;ve tried, my sex drive is very low and i had moderate headaches for the first couple of weeks, so i won&#039;t pick on zoloft for that.  overall, extremely satisfied, i can&#039;t imagine my life without it."