"have been on parnate for over 20 years, use with trazadone, and i take 40 mg parnate, divided does and 250mg trazadone at hs. i had ect treatments 20 years ago, but had battled major depression since high school. i do believe the parnat has kept me on even keel for many years. i have found with the list of everything else you can not take with it nutrasweet threw me into a hypertensive crisis..so heads up with that. other wise, have never had any side effects with parnate"