"on my 8th day of using spironolactone 50 mg twice a day and every day my skin looks better. after numerous visits to the dermatologist, prescribing me different antibiotics and topicals i went to my real doctor and she told me it&#039;s got to be hormonal. i haven&#039;t had any cystic acne since i started this and i would at least get one or two a week. the doc also put me on clindamycin phosphate which i think is helping clear me up. only 8 days in too! hope i&#039;m not speaking too soon. "