"i&#039;ve been on 75 mg twice a day for three months which took the edge off my sciatica but did little for lower back pain. a week ago my dosage increased to 150mg twice a day and my back pain is good and sciatica is gone. additionally my general anxiety is eased. there&#039;s no worsening of my depression symptoms (i manage depression/anxiety with efexor). aside from mild sedation i&#039;ve had a great result from lyrica so far. hope it continues working this well! :)"