"i was on generic bupropion for almost 2 years (hcl xl 150 mg) and it was ok. it did help with the depression but towards the end of the day (took pill 7 am) by 5 pm i was feeling down and irritable again, i never really thought about it until everything i&#039;ve read about the generics having time release issues so i know it&#039;s not just me!  i def had more energy, and was good during the day, but 5pm i shut down emotionally. i tried switching to generic bup hcl xl 300 mg last year but only made it 5 days in before switching back due to anxiety/no sleep side effects. i really hated that my mail order rx company would switch manufacturer of my drug-one bottle was from global and the next actavis. now on brand wellbutrin xl300mg and hoping it wrks!"