"i&#039;ve been taking bupropion 150mg xl for a number of years. it has worked quite well for me, but i began taking it just every other day, and i find i&#039;m still doing well. i don&#039;t like taking any more medication than i have to.  i also take generic lexapro 10mg at bedtime. i started to notice a big difference when that was added about 3 yrs ago. it doesn&#039;t put me to sleep, but helps turn off my mind so i can. i&#039;ve tried decreasing use, like with the buproprion, but that didn&#039;t work. depression increased. the only thing i don&#039;t like is that i just don&#039;t feel happy as often as i used to; sometimes i realize i feel kind of blank, and don&#039;t think i should. but it&#039;s worth not feeling depressed. my brain thinks before my emotions kick in. good!"