"i have horrible arthritis pain for many years...tried everything..i&#039;ve been on vicodin (10mg) 4 a day for about 6 years..finally a pain clinic dr. gave me zohydro (40mg) 2 a day. i would say i am 80 percent pain free. overall quality of life has changed.  no more ups and downs. i have to remind myself to take the second pill. thanks zohydro!"