"i have major depression. also i have a spinal fusion.i have tried many depression drugs. i also suffer from a sleep disorder that makes me sleep through a lot of the day. with pristiq i definitely feel better in the morning and that was the worst time of day for me. i am still suffering from excessive sleepiness during the day. i have been on pristiq for about three months now. so far its been pretty good. i would recommend it, but it is not a miracle drug for me. i still have depression.i was hoping for a bigger difference."