"in the first 3.5 weeks i lost 12 lbs.  my doctor said it could be an anomaly and not to be upset if the next 5 weeks don&#039;t show this type of weight loss.  the first 2 weeks i felt no different and then it kicked in and i stopped thinking about food and my appetite really decreased.  side effect is constipation for which i take a metamucil and it is working. my total weight loss since being under doctor care is 38 lbs. i was on another med, but broke out into an uncontrollable itchy rash and had to stop.  i encourage people to keep at it (contrave) because it does take time to see any difference/results."