"i am female 48 years old, healthy except for being over weight. i have tried every diet possible with little success. been the the doctor and my thyroid is working well.  i was working out 5 days a week (p90x lost inches but no weight)  and still with little to show for all my hard work.  i started 1 1/2 weeks ago on 105mg and lost 8 lbs.  i am eating approximately 100 calories for breakfast, &lt;300 cal frozen diner and a banana for lunch and at dinner i am eating half the amount that i usually eat.  my plan is part doctor prescribed and part learning portion control.  my problem is not quality of food but quantity.  i have heard that your brain gets used to the medicine and should take a week off every 2 weeks.  i start exercising next week."