"i have adhd and mild-to-moderate anxiety. dexedrine 20 mg (2 x 10 mg) taken in the morning allows me to focus for about 8 hours, but i experience negative side effects including increased anxiety, raised blood pressure and difficulty sleeping. i used to experience moderate-to-severe depression at the end of the day when it would wear off, but i&#039;ve been able to avoid this using buspirone 5 mg (taken once-an-hour for 4 hours starting 7.5 hours after i take the dexedrine). also, i take trazodone 12.5 mg before bed to help me sleep. due to the side effects, i only take dexedrine once or twice a week, when i need to get lots of work done. adderall made me more anxious, and methylphenidate (e.g. ritalin) didn&#039;t help me."