"so far i haven&#039;t seen anyone on here that&#039;s been on remeron/mirtazapine 45mg at night for more than 6 years. i&#039;ve been on it for 11 years. i was put on this medicine in 2002 after my daughter was born. to save all the details my physical and mental health went out to rest somewhere leaving me in a body and mind that didn&#039;t belong to me. they tried me on every medicine available and nothing worked. the negative long term of this has been: weight gain, dizzy sometimes, dehydration and laziness. the positive is it gave me my life back. i like others here have found it&#039;s notorious for appetite. i could eat sugar right out of the bowl. i have had to make myself be more disciplined in my eating and exercise. i combat dehydration by keeping a cup of water with ice in it filled and drink on it all during the day. i am also moving into menopause so have to be very careful. i&#039;ve heard some talk about the nightmares. yep, have them too but only if i eat sugar before bed. lay off the food 4 hours before you go to bed and it will get rid of those monsters under your bed. i have post traumatic stress disorder and that causes most of my nightmares. still my sleep is awesome. i still have some anxiety from time to time but use klonopin 0.5 to cut the edge off only when needed. i tried going off about 5 years ago and after about 3 days i couldn&#039;t sleep, think, or operate at any type of normalcy. i will have to add i also gained a concentration level i never had before. i went from a school drop out that couldn&#039;t learn to a 3.9 gpa (40 year old) who loves to read and learn! compared to all the other stuff out there (and their side effects) i would have to say remeron has proven to be the very best antidepressant i&#039;ve ever taken."