"i am currently 21 years old, but started taking pristiq a few years ago. i had previously tried prozac, then effexor, but i couldn&#039;t see much of a difference. once i started taking pristiq 50mg, i felt the results within the same week. it was great. however, whenever i missed a day i would feel the adverse side effects almost immediately. brain zaps, depersonalization, dizziness, foggy thoughts, nausea, sweating, crying spells, headaches... i eventually got off of it (i honestly don&#039;t know how) but it was a very difficult 2-week process. two years later i am back on wellbutrin (after a bad experience with lexapro). pristiq was definitely effective but extremely addictive. not something i&#039;d recommend without reservation."