"i have tried many medications over the years, mostly antidepressants but a few others like lamotrigine &amp; seroquel. i must say that nothing has been more effective than latuda. i was on wellbutrin for a couple years, was ok. this does make me drowsy so i take it at night. i do have to take with food or will make me really nauseous. truly a miracle drug as i was not doing well."