"worst birth control i&#039;ve ever been on. even compared to needing my mirena iud surgically removed. all birth control comes with side effects but i had the worst experience with the depo shot. i stayed on it just over a year and a half (thinking it would get better eventually?) and i decided not to continue it, with all the issues i&#039;ve had. zero sex drive, extreme fatigue, lots of weight gain, major anxiety (needed medication), moodiness.. now that i stopped, i&#039;m having major abdominal cramping, similar to mild contractions. i would not recommend this birth control. i feel like i&#039;ve become a completely different person with all these mood changes and fatigue. i hope i can get back to normal after this. really regretting doing the depo.."