"i&#039;ve been a chronic pain patient for 10 plus years. my dr wanted me to try hysingla 100 mg even though my other medication was working the best out of all the others i&#039;ve tried and been on.  i took the first does and i didn&#039;t seem to have any relief but i kept reminding myself what he and i discussed so i gave it another try.  by this time my other medication is no longer in my system and now my pain is getting really bad so i called my dr&#039;s office. i was advised that the hysingla would peak at 15 hours of taking it and sometimes takes a while to build up.  after a few days my dr took me off of it, an asprin worked better then the hysingla.  i hope others don&#039;t have to suffer like i did."