"i have been on venlafaxine up to 225 mg a day!-for almost 15 years..in july 2015 i began feeling very low and having great episodes of anxiety-i had a panic attack for the very first time in my life and bagan to realise the medication was no longer effective- i was referred to a specialist depression drug consultant-i described my lack of energy and low mood -he thought i would benefit from introducing 50mg alongside the 150mg of venlafaxine-so this is what i did- and felt wonderful-until my gp said i should taper the venlafaxine off-i am now taking only the sertraline 50mg-i am like a zombie- all i want to do is sleep-i crashed my car (15 years no claims) and have zero motivation-i will give it until the end of january and re consult the gp"