"started at 25mg twice a day, then 50mg twice a day.  definitely helps my appetite!   easily drop 10 pounds a month when i behave myself and have lost 80pounds so far.  when i went to 75mg twice a day i started feeling in a fog and definitely getting a bit zombie so i dialed it back to 50 twice a day and am carrying on.  i started at 404 and am currently at 315.  i would imagine like anything,  you have to work with it but i am thrilled!  still a long ways to go, but i got a good start!  i like it!"