"i started brintellix 3/16. i didn&#039;t have the gi issues that many do. but it affected my sex drive and made me tired. my dr said to take it at night. when i did, both issues subsided. i felt much better! i had a more positive outlook. i took on a 2nd job, which shocked my dr - as a lot of my depression is work related. in sept., my pharmacy started filling it as trintellix. my dr says there isn&#039;t any ingredient changes in the medicine - just the name. i&#039;m not convinced. i&#039;ve been having mild depressive episodes since sept./oct., and they&#039;ve gotten worse. i thought it was dehydration, but i can guzzle down water and it doesn&#039;t help. this medicine has been amazing for me up until recently.  maybe i need to up my dose?"