"i&#039;ve been on this medicine off and on for almost a year now. after i am on it for a few weeks, my joints start to hurt really bad. i think it is because of the diuretic nature of the drug. it doesn&#039;t stop the black heads. it also makes me get up in the night to pee. my dermatologist says he has never heard of the joint pain being a problem and refused to believe its the spironolactone causing it. but after starting and stopping the medicine three times, i am sure it&#039;s the cause."