"i took minocycline for my mild acne for about 2 weeks with no problems. i was very happy with my results. until i started experiencing hives. the first day they showed up on my hips, then when i woke up the next morning they were all over my body on my waist, back, knees, elbows, hands, and even a couple on my face. they itch and hurt so bad. when they showed up on my feet, i couldn&#039;t walk. i couldn&#039;t get up to go eat, my sister had to come to my room to get me dinner. my hands became swollen and puffy, with hives all over, i can barely write. i stayed in bed the majority of the day. my doctor prescribed me with benadryl and prednisone, which helped because i woke up this morning with some improvement. i don&#039;t recommend minocycline."