"one of the best-responding antidepressants i&#039;ve ever taken. unfortunately, i had to stop taking it because my resting heart rate went up to &ge; 100 bpm while on this medication (could&#039;ve been interacting adversely with my dexedrine). but wow, what a response i had! it started responding just a few weeks after increasing it to 75 mg, and it seemed to really bring me out of my cocoon at 100 mg-125 mg. that was the highest i ever got to try before realizing what was going on with my heart, and subsequently having to back down on the dosage. my positive response diminished, and i had gained a bunch of weight anyway, so we decided to switch meds."