"i started taking cymbalta in april 2011, and when i first started out on it i experienced, extreme tiredness, insomnia, dry mouth, constipation, hot flashes, strange dreams. i still get very odd sometimes disturbing dreams but i think a lot of it has to do with recent stresses in my life (grandma having a stroke, work stress) and still experience constipation, hot flashes, and night sweats but it&#039;s not the end of the world. it has so far been the only antidepressant medication that has really helped me and i have been on lots of different ssri&#039;s and atypical antipsychotics. i have good and bad days like anyone does, but if i do get sad and cry it doesn&#039;t seem to last long. so in my opinion the benefits outweigh the side effects."