"i started on the lowest dose about a year ago, i was use to taking my meds at night. seeing i take 2 different meds for neuropathy, its just easier to remember to take all meds before bed. well effexor literally had me up for 2 days straight, so i contacted my doctor who said to start taking it in the morning. i am now on 225mg every morning, and am doing better. i do take it for depression, &amp; anxiety which i have fought with since i was a teen. effexor is the only one that has truly help, and i haven&#039;t giving up on."