"i was prescribe 50mg 4x a day and then moved to 300mg extended release.  while on the 50mg 4x a day, i noticed it took about 15 minutes to feel some relief from my joint &amp; nerve pain.  the only problem was each dose only really lasted for about 20 minutes.  the first does ever was a oh yer finally some relief, that lasted 20 minutes. that was the reason we switched to 300mg extended release.  again, it took about 15 minutes to feel a decrease in pain.  with the extended release, it still only helped for a short period of time, maybe an hour or two.  i stuck with it for about 4-6 weeks hoping it would build up &amp; eventually relieve pain for a good portion of my day.  honestly, it only cut pain by about 50% &amp; never lasted longer than 2 hours."