"started out on 150 mg of bupropion hcl xl and saw results after 7 days of use.  by day 30, i was feeling great about 80% of the day, experienced usual depression issues late at night.  next month my doctor upped my dosage to 300 mg/once a day in the am. feeling better at night now after the increase.  another bonus--dropped 11 pounds in the first month.  motivation is better and getting things done."