"onexton was my last resort before accutane and i am so glad my derm prescribed it to me. i had hormonal cysts that were painful and inflamed. i&#039;ve been on onexton for six months and now i have no acne at all. i feel like i tried everything and this was the only thing that worked for me. your skin does need time to adjust to it because it&#039;s a powerful medication, so make sure you&#039;re only using a small amount at first. i like to mix mine with moisturizer and apply at the same time. seriously has been a lifesaver."