"i&#039;ve been on tri-sprintec for about 8 months and it is really effective. so far, i&#039;ve had shorter periods (4 days) and i don&#039;t notice a lot of acne or emotional issues. however, i have had a weight gain of about twenty pounds on this medicine despite the fact that i was actually exercising more than i did previously. i&#039;ve always had problems gaining weight and had been about 105 lbs for quite a few years so a few pounds wouldn&#039;t have hurt, but this weight gain was pretty troubling due to how rapid it was. i wanted to wait and see if things slowed down but i think i am still gaining so i may talk to my doctor about switching to a different pill."