"i have been on so many ssris over the last 30 years. nothing has decreased the dark place i was always in. it has caused my friends and family to try and disguise the depression. very sceptical about remeron. last night was night 1 and woke up twice for potty, no probs. woke up and it only took 2 hours to be alert. it works. i&#039;m not in the dark place, i feel good.if it keeps getting better then i thank god. for the most part i can think clearly , just a hint of anxiety but so grateful.don&#039;t be afraid to try it."