"i&#039;ve been on epiduo for about a month. and yes, for the first week and a half, maybe 2 weeks, my skin was irritated and it burned when i put the gel on. however it subsides over time. today when i put it, there is 0 irritation. anyway, i had a breakout when i was started but right now, my skin is pretty clear and amazing compared to before. i do still get a few pimples here and then but nothing major and definitely not like anything compared to before. i will say that using epiduo in the first month has its ups and downs. there&#039;ll be some days where you&#039;ll be like &#039;this isn&#039;t even helping!&#039; but just wait it out."