"i&#039;ve taken loratab 10/500 for about 3 years for osteoarthritis in the knees and i don&#039;t know what i would do without them. i was taking them prior to my knees being replaced and still take them for hip pain. the only negative side effects i&#039;ve noted is occasional constipation, which is consistent with any narcotic. i take 3-4 every day, but i have begun to notice that they are not as effective as before. i&#039;m sure i&#039;m developing a tolerance to them also. but i would recommend them for chronic pain for anyone who can tolerate them."