"i started deplin after having genetic testing and learning i had gene mutation.  after 3 days of 15mg of deplin i developed a raised red rash on both checks.  from day one i noticed a huge difference in my mood and depression.  i have tried probably 30 anti depressant over the years.  after researching online i plan to get the 7.5mg dose and cut it in half and start at a smaller dose.  as for now i am stopping it until my rash clears up once clears up i will start taking half of a 7.5mg tablet.  hopefully i won&#039;t get rash from that lower dose.  but definitely recommend especially if you treatment resistant depression."