"along with celexa at 20mg, for about 5 weeks, i take 150mg of wellbutrin, and 40 mg of methadone. i&#039;ve had several back surgeries so live with chronic pain.  along with an improvement of depression and anxiety, i noticed that my appetite has decreased. no weight gain, maybe lost a couple pounds. i noticed improvement on the first couple days! i&#039;ve tried prozac &amp; welbutrin, individually &amp; together, but not much help.  i recommend giving celexa a try over any other medicines."