"cant give a full review yet as this is my second day of taking this medication, but i will give updates to those interested or with a similar case as mine. i&#039;ve tried many different ssri but it seems my system but for reasons unknown my body wont tolerate them. i am a fairly strong and tough guy physically but the side effects were too much for me to continue. for over a month now ive been taking mirtazapine, came to taking 30 mg but ended up with really bad arthralgia so i came back down to 15 mg. been taking that and it seems to helped a little with my depression and anxiety. managable symptoms at least, but at this point any subtle improvement means a lot. as far as trintellix, so far so good. no nasea or vomiting"