"my doctor put me on bupropion sl 150 mg once daily for depression and inability to handle stress.  in the past i&#039;ve taken elavil, celexa, st. john&#039;s wort and lexapro. lexapro made me gain weight (40 lbs in 1 year) although it did help with the depression.  i accidentally took 2 pills the 3rd and 4th day i was on bupropion and felt a little manic, although i did get a ton of chores done. it pretty much kills my appetite, which is a wonderful side effect because just losing weight helps me not feel so depressed. i&#039;ve already lost 5 lbs in the week since i started taking it. since i feel i also suffer from sad i&#039;m looking forward to seeing how this medicine will help me through the winter.  if bupropion works for me i plan to stay on it forever."