"so i was put on duloxetine over 1 year ago. this was after i had tried about 3 different anti-depression medication that didn&#039;t help. i was first put on 30mg that made me slightly better but i stall felt constantly sad with no energy to do things . so then they increased the dose . now i&#039;m on 60mg. i have to say the drug saved my life , after years of constant suicidal thoughts and trying to harm myself i no longer feel the need to . i wouldn&#039;t say it makes you feel happy , it just makes you content . i have been rather lucky and not had to many side effects . i am quite tired but than i do think that&#039;s depression not the tablets .  it&#039;s a great medicine to take but if you miss a day or come off it&#039;s like hell . like depression has engulfed you entirely."