"i have found saphris to be very effective, especially for my bipolar depression. i felt happy for the first time in 4 months and its only 2/3 days to work! i was taking lithium and lamotrigine, but the lamotrigine didn&#039;t bring my mood up and the lithium didn&#039;t either. needless to say, i was feeling pretty down. saphris made me feel clear thinking, motivated and reduced my anxiety. and it has only been a week and a day since starting it. i am very pleased. i still have a ways to go in terms of my over all experience with this medication. all the best."