"i have bipolar 1 disorder and though i manage my condition with lithium, i have trouble getting to sleep at night which leads me to insomnia which ultimately leads  to manic episodes. i take between 12.5-25 mg a night of the seroquel and it works within about 45 minutes or an hour. it puts me right to sleep. it&#039;s the only medication that has ever consistently worked on putting me to sleep. i feel a little bit groggy in the morning sometimes if i take 25 mg. also it increases my appetite at night. i&#039;ve probably put on a little bit of weight because of my snacking but it&#039;s so worth it to me."