"i have unipolar depression with occasional manic symptoms.  for 20 years i was on antidepressants but started quetiapine about 6 months ago in conjunction with citalopram.  when i reached a daily dose of 300mg i was feeling great mentally.  but the side effects of constipation and tiredness made it difficult to stay on this medication long-term so i&#039;ll be trying lamotrigine next."