"i suffer from severe anxiety &amp; mild depression. i had no idea how this was ruining my life. i was so nervous to try medication but finally got the point that i was desperate. tried zoloft, wellbutrin &amp; celexia. felt awful or had such strong side effects that i couldn&#039;t continue them. finally tried effexor at 37.5mg for 2 weeks. those 2 weeks were absolute hell. so sick &amp; emotions were all over the place. i was about to give up on it but my doctor suggested 75mg. wow! what a difference. still have the side effects (nausea, constipation, some dizziness, loss of appetite, brain fog) but hoping those go away as i&#039;m only on week 3 now at new dosage. mentally i&#039;m already feeling better! not sure how much for my anxiety but definitely for depression"