"i started taking venlafexine 75 mg daily 5 weeks ago for major depressive disorder. i was first tried on prozac 40 mg and it did not help at all. for several months i was feeling constantly exhausted, no energy, no motivation, crying, and missing a lot of work. on the 2nd week of venlafexine i noticed i wasn&#039;t feeling so exhausted and starting to get my energy back. i am now on week 5 and feeling like myself again. i&#039;m able to get through work and come home and take care of things around the house. where before i was leaving work early and going straight to bed. i am very glad my doctor started me on this medication. before the prozac i had never been on any medication before. i have had no side effects or weight gain."