"i have bp2 and was put on remeron for a crushing depression that lasted for several months, which cymbalta was not helping, even though i had been on it for many years. at first, remeron was my miracle drug. within 48 hours, my depression had broken and i no longer needed to take ambien to sleep at night. but within a month, i put on 14 pounds and that was completely unacceptable. i went off remeron immediately, with no withdrawal symptoms. if you are depressed and don&#039;t have weight issues or are experiencing decreased appetite, this is the drug for you. but for anyone that struggles with their weight, i would not recommend it."