"i have chronic depression (dysthymia) &amp; anxiety, &amp; the depression worsened recently despite being on zoloft &amp; wellbutrin. my psychiatrist suggested we try rexulti &amp; wean me off the wellbutrin. 

i started on 1mg, &amp; i had a slight headache for the first two days. after that, i felt like i was doing a little better and my husband commented that i was more active than usual. my dose went up to 2mg a couple days ago. now i feel like i can really tell a difference! i haven&#039;t felt depressed, i have more focus and creativity at work, &amp; i&#039;ve actually had enough motivation to do chores at home. i&#039;m a little restless, which i&#039;ll keep an eye on, but i haven&#039;t noticed any other side effects besides that and the temporary headache. i&#039;m optimistic!"