"i&#039;m a diabetic with peripheral neuropathy. i was started on 30mg oxycodone immediate release 3 times a day and methadone 10mg 6 times a day. they have both worked wonders! recently i developed bad infected foot ulcers and now have a hole on the side of my left foot and open sores/wounds at the bottom of both feet and my doctor upped my dosage to 30mg oxycodone immediate release 6 times a day and methadone 10mg 9 times a day and with the methadone, the oxycodone has no &quot;high&quot; effects. i am so happy my quality of life has raised and i am able to walk almost normally with little to no pain during most of the day. i have gone through the withdrawal by missing 5 days of both medications once and it is bad. other than that, it is a god send!"