"i have been on 200mg of buproprion xl for about 2 years and i can say that it has had a great effect on my life.  first off, i quit smoking.  the urge to smoke was like, gone!  my mood was great for about 1 1/2 yrs and i feel that this is a great medicine for most.  i did gain weight on it and my appetite has actually increased, so i guess i am one of the unlucky ones.  i have noticed some withdrawal symptoms if i miss a dose, which is something else to consider.  it has stopped being effective for me and i am concerned about raising my dosage due to the withdrawal symptoms i have experienced.  i am constantly tired and lethargic and recently had a major depressive episode. "