"each person reacts differently to anti-depressants. this is input from both me and several other patients i have spoken to in the hospital and outpatient programs with similar accounts: wellbutrin is a miracle drug for some people, but, especially if you are bipolar, you have to be extremely careful about the dosage. i&#039;ve had severe depression symptoms for 10 years. after a month of starting, i didn&#039;t have what i would consider a moderate depressive episode for the next two months, and can now enjoy life again. but previously, i went on a dosage that was too high, and rapid cycled terribly. communicate a lot with your doctor. i did have frustrating side effects, but they subsided. you can&#039;t just assume how a drug will work after two weeks."