"i have been on these patches for about 2 years. i started out on the 25 mcg&#039;s and now am on the 100 mcg&#039;s, and i change them every 48 hours. they work great. i also am on oxycodone 15&#039;s 1-2 every 4-6 hours for break through pain, but i usually do not need to take them that often. i have a rare muscle condition that causes extreme pain. during the years prior to being on these i  have been on just about every type of pain medication,(narcotic and non-narcotic) that you can think of. i must say that these are by far the best and i would recommend them to anyone that has real issues with pain. they are not for people that just have occasional migraines or back pain."