"have &lt;20 to lose with elevated a1c. started mid-july with weight watchers and upped exercise. have pre-existing but treated grave&#039;s disease. was intrigued by contrave because of potential to help me quit my smoking habit as well.  during &quot;build-up phase&quot;, i lost 2-4 lb. i can only say i had dry-mouth which i rectified using biotene.  i made sure to eat before taking it (as directed).  no notable difference the 1st 4 weeks. many times i was famished between doses, so i lost and gained the same weight and no reduction in smoking.  at my 1 month follow up, my dr. urged me to stick with it another month.  shortly after i noticed i went from 4-6 cigarettes per day to barely 1 + my appetite has lessened.  jury still out...but there is hope!"