"started phentermine 37.5mg/ topiramate 50mg back in jan 2013. lost 50lbs in 2.5 months. 75 all together. drastically watched what i ate and worked out 6 days a week. the lack of memory/concentration weren&#039;t enough to make me stop but very noticable. i also get neuropathy  (pins&amp;needles feeling in my feet, hands and nose). i went from 225, size 18 to 150, size 6. 65 of those lbs found their way back in 1.5 yrs. starting again... but i know i dont have the same motivation i did before.... :( definitely works better if you put in effort!"