"i was on depo-provera for 15 months and the only negative side effect i experienced was weight gain, which is why i recently stopped. i loved the ease of the whole process and the high efficacy of the drug. i had 2 periods my entire time on the shot (yay!), didn&#039;t spot, it didn&#039;t break me out, didn&#039;t mess with my mood, but i gained a lot of weight (which did plateau). when i got off, i immediately got my period and my skin broke out worse than it has in the last year. i also am experiencing a definite decrease in energy. overall, i recommend the shot and i may go back on it in the future, but pay attention to your side effects!"