"this medicine is a miracle. i&#039;ve tried prozac, effexor and wellbutrin. since i&#039;ve been on pristiq, i no longer feel sad and cry the way i used to! i&#039;m finally happy! i thank pristiq for this! the sadness seems to creep back in however when i&#039;ve missed a dose, so its imperative that dosing remains consistent. i&#039;ve found taking it in the morning is best as it does cause sleeplessness. other side effects i&#039;ve noticed are; constipation, loss of appetite and substantial weight loss. after reading a few reviews, i laughed as i read another pristiq user describe how they now &quot;ramble on and on&quot; when talking to someone! i too, do the same thing! i so glad to know it may be a side effect of pristiq! take note my dear family! perhaps i&#039;m really not a &quot;wingnut&quot; after-all."