"i&#039;ve been on pristiq for about 2 yrs, started on 50mg but after a couple of months i started feeling very moody, dr put it up to 100mg, again a few months later same thing happened, had it increased to 150mg, i&#039;ve been on this dose for over a year, dr. never thought i would take this dose as i am small frame and only 55kg. i started taking it at night and found that my mind was going at a million miles an hr, did not sleep for a week, changed to the morning which works well. as others have mentioned, if i miss a dose i get dizzy. pristiq has helped me, saved my marriage, and my life, i am calmer, anxiety gone, mood swings gone, suicidal thoughts gone. give it time and if all else fails get help. good luck!"