"adding just 37.5mg of effexor to my 15mg of remeron had quite an impressive effect for my depression and anxiety. i titrated to 75mg and have stuck with that for several months with great results. this is the first medication that i feel has truly worked for me. (in the past, i&#039;ve taken bupropion, hydroxyzine, propranolol, gabapentin). the combination with mirtazapine makes for almost a perfect synergy. i feel that i have achieved true therapy and healing since i started taking &quot;california rocket fuel&quot;."