"i started out on a 25mg dosage and am now at a 75mg dosage.  at first, spironolactone made the acne on my face, back, and chest much worse; but i stuck with it (because i was ready to do about anything to get rid of my acne), and my skin is almost completely clear now.  yes, it did take about 4 months to work, but it&#039;s totally worth it.  for the first time in my life, i have no blackheads!  i&#039;ve been dealing with cystic acne since i was 16 and finally, at age 25, i&#039;ve found something that controls it.  the only side effect i noticed was that i got my period the day after starting spironolactone, but it&#039;s been normal since then.  highly recommended, but you have to stick with it through the tough times at the start."