"after years on prozac switched to wellbutrin xl 150mg 5 days ago.  i had gained at least 40 pounds while on prozac. on day 5 of wellbutrin xl 100 mg and so far so good.  i am waking up throughout the night, no appetite which isn&#039;t a bad thing - down 4 pounds already - much more energy - however i am finding my ocd tendencies are getting stronger and things that i would let go couple of nights kept waking up throughout the night. but appetite - no appetite - down 4 pounds.  do find that some of my ocd issues are stronger than they were before..not too bad so hopefully things will settle down on that front and the anger issues where i am angry at anyone and everything will settle down also."