"i have been on the depo for 10 years!!! and it has been wonderful!! i don&#039;t have mood swings, i don&#039;t have depression. i feel a little blue on the day of the shot but that&#039;s about it. i did experience weight gain at first, i was 128 lbs starting on it then ballooned to 165 in the first 3 years, and now hover at 153 lbs (without real exercise but watching what i eat), i&#039;m 5&#039;6&quot;. the only reason i&#039;m getting off of it is because my current obgyn, who i switched to after 5 years of being on depo because my last obgyn retired, freaked out that i had been on it so long and wants to give my body a 1 year break due to the bone density loss issue. no acne, and my periods stopped after 6 months."