"i have been on tri-sprintec for about a month now, and really like it! when i started, i did notice that i was a bit over-emotional, but my life in general was pretty stressful then so i&#039;m not sure it was the medicine. i have not experienced any negative side-effects yet, but i haven&#039;t really noticed that it has cleared up my acne any. periods are light and almost painless and i&#039;m definitely not pregnant, so it works for me!"