"i&#039;m on week 4 of taking pristiq, i had nausea, loss of appetite, foggy head, sleepiness during the day and sleeplessness at night for the first week.  the side effects are all gone now, and i think i&#039;m starting to feel a bit less depressed.  i think this medicine affects a person so gradually that it&#039;s hard to tell for sure if you are improving.  but when i look back to 5 weeks ago, before i started, i think i&#039;m less depressed.  i take 50 mg in the evening.  i was taking it in the morning because my doctor said i might sleep better at night if i take it in the morning.  but i found that i was very sleepy in the early afternoon when taking pristiq in the morning.  so i slowly changed to taking it at night."