"i&#039;ve been on depo for 15 years, i initially started it for birth control, but have since stayed on it because it controls my pmdd. i went off of it once in this time frame, and my pmdd came roaring back, along with my periods. other than the time i went off depo, i have not had a period in those 15 years and my pmdd is fully under control while on it. i have not experienced any negative side effects."