"been on zoloft 25mg a week. it killed my depression (almost) and my anxiety. i&#039;ve been an opiate addict for 6 yrs and only quit 1 week ago. i can&#039;t believe i have no interest in painkillers all of a sudden. several side effects occurred the first 4 days. insomnia/ migraines /diarrhea. it&#039;s impressive now though."