"i&#039;ve been on the generic version of wellbutrin sr 100mg once a day a little over a week. added to supplement my 20mg prozac twice a day, and .5 klonopin twice a day. i&#039;ve been on the prozac and klonopin over a year and it began to be not as effective. i began to feel very depressed along with my anxiety also i&#039;ve gained about 20lbs so my psychatrist prescribed 100mg wellbutrin sr once a day in morn to help. so far i&#039;ve noticed i&#039;m extremely tired about 1 hour after taking, so tired even my strongest cup of coffee can&#039;t keep me awake. i know prozac and klonopin can have this as a side effect but my body is well adjusted to that now, those side effects are long gone.i&#039;ve noticed better focus and reduced appetite, so now i will just wait."