"i have been taking nucynta for about three months and take only 2 x 50 mg tablets per day.  at first it worked very well with no side effects, except i felt euphoric and a bit sleepy. therefore, i only took nucynta at night.  but now in the mornings i notice that i wake up very depressed and unable to handle the day.  i do find that 1 plus hours of morning exercise helps me get over these feelings.  i believe i need to ween myself off of this medicine."