"i have been on and off zoloft (lustral) for about 8 years.  my usual dose is 200mg but every time i try to come off them depression comes back with a vengeance.  i have severe treatment resistant depression and have had over 60 ect treatments. zoloft has been the only antidepressant which has helped me in any way and believe me i have been on them all. but as everyone is different i can&#039;t say it will necessarily be the one for you but in my experience of all the tricyclic antidepressants, ssris and maoi&#039;s, zoloft has far outweighed the others.  as i&#039;m here just thought i&#039;d mention that i am also on a new antidepressant called valdoxan which is very new and also very good. it is available in europe but i&#039;m not sure if its available in the united states yet. good luck. "