"i have had a good experience after trying to find the right cocktail for several years. i have a very high-stress job and my anxiety is put to the test daily. it is not clinically significant at this point and i can only attribute that to finally having my medicines right. i am taking wellbutrin, lamictal, topamax and zoloft at pretty low dosages for each. i did lose about 70 pounds. after over a year on the topamax, my normal appetite has started to return and i have gained back about 10 pounds, but i still have self control that i lacked when i was fighting depression which is now at bay."