"i am a 63 year old man (a psychologist) who has had treatment-resistant depression for many years.  in the past ten years i also have had frequent (10-15/month) migraines--migraine and mood disorders often appear together.

i started on deplin 7.5 mg/day along with zoloft 50 mg./day last month.  i had been on zoloft alone previously with no improvement.  after 3-4 weeks of no change in mood or functioning, my psychiatrist increased the deplin to 15 mg./day and the zoloft to 75 mg./day (not a high dose).  within a few days, i experienced an increase in energy and sharp decrease in depressed mood--to the point where i&#039;m feeling back to what &quot;normal&quot; was decades ago.  i have been through numerous antidepressants and never experienced this."