"i have been taking the 75mg time-released tenuate for 12 days now and i&#039;ve already lost 6 lbs.  i take it in the morning; after it kicks in, i feel a little shaky and nauseated for about an hour (but it&#039;s not disabling); after than i&#039;m fine for the day.  i have to be careful because, if i&#039;m really busy i&#039;ll forget to eat.  i was concerned that it would keep me awake but it seems to wear off in the evening.  i think drinking plenty of water is probably pretty important with this medicine."