"paroxetine worked absolute wonders for me when i first started the paroxetine 6 years ago.  my mood elevated so high to the point of work colleagues questioning my &#039;nightclub activities&#039;. the &#039;serotonin high&#039; also made me aggressively confident and involved a few flashpoints including a physical fight- my first for 15 years. while it worked it was great.  however, it lost it&#039;s efficacy suddenly a few months ago and i was prescribed sertraline/zoloft which was a disaster.  headaches, nausea and insomnia was my bodies reaction to this medicine.  have now been put on citalopram and hoping this will be effective.  my doctor suggested i may try paroxetine again if i don&#039;t respond to citalopram."