"bipolar ii with severe anxiety. saphris is doesn&#039;t work for most people but for the ones it does work for, it can be a life changing miracle drug.  that&#039;s been my experience. i spent 10 years either so depressed or anxious that i could barely get out of bed.  i took my first dose at bedtime and when i woke up the next mrning the anxiety was gone. it gave me my life back. i take the whole daily dose at night.  it knocks me out cold for at least 3 hours and i can&#039;t function at ali if take it in the morning. i had horrible mouth sores.finally figured out that it was from the dry mouth caused by my other meds. now i take a sip of water first and after it dissolves, i suck on a caramel or a couple of pieces of candy. "