"i started trimethoprim just over a week ago and at first i felt sick and headachy so i made sure i had the tablets with food and it was fine. i noticed a huge difference in my skin in only just over a week and i thought this drug was working wonders after trying everything else(this was my last resort before accutane) sadly i broke out in an awful red skin rash 2 days ago which has gotten worse and worse, even though i am no longer taking the tablet. it&#039;s a shame because it was working wonders for me! i would have definitely continued had i not got a reaction to it."