"started this medication on feb. 3 and am now in my 3rd week and using the dose of 1.8. since the beginning, probably by the third day, i have felt the shot working.  it definitely curbs my appetite and i&#039;ve been lucky with only very minor nausea in the first day or two when upping my dosage each week.  back in december i weighed 262 lbs and now i&#039;m down to 250.4 lbs.  i believe this is helping. i can&#039;t wait to see what can happen when i&#039;m on the full dosage."