"i learned quickly that what works for one may not work for another.  i was on wellbutrin, which worked pretty well for me, except for the ringing in my ears.  my doctor then suggested cymbalta and i felt worse almost immediately.  we stuck with it, and even increased the dosage, but i felt like i was slipping back into darkness.  i had neither energy nor interest in anything.  i then began pristiq: four weeks at 50 mg and now 100 mg.  i&#039;m feeling better than i have in many months.  i had a bit of nausea at the beginning and then some headaches when i first bumped up to 100 mg.  in conjunction with an effective therapist i was lucky to find, i&#039;m finally feeling (cautiously) optimistic about this thing called life."