"i have been on depo-provera for 4 shots (1 year) and i have had relatively little side effects. before depo i was on regular ortho-tricyclen pills and ortho lo. on both previous methods i definitely gained weight (at least 5-10 pounds) and was moody with total lack of libido. i also got headaches a lot - not really bad ones but annoying enough. when i went back to get my prescription refilled, i told the doctor about the headaches and that one of my eyes was becoming slightly nearsighted. from these two factors, she recommended the shot rather than the pill. i had slight spotting, then periods were gone after 2nd shot, no headaches, small weight gain, and still less interested in sex than i would like to be but no birth control is perfect. try it."