"i&#039;ve had acne for a long time, all my teen years into adulthood. i&#039;m 29 now and finally asked my doctor to prescribe something. i&#039;m about 3 wks into taking doxycycline and i had noticed slight improvement until a few days ago. i just got my period and dear god, my acne is more cystic and crazy than ever! it&#039;s mainly on my cheeks and chin now (which seems to be what others have experienced on this medication) and they are large, painful and ugly. ugh. i&#039;m truly hoping this is the whole &quot;getting worse before it gets better&quot; thing. i&#039;m gonna stick with it and hope that this is just a one time thing. i also began using the acne free severe system with this med, so we shall see. oh, and the first day i took the med, i vomited. must eat prior!"