"i have been taking pristiq for a little over a year now, and i am very happy with it. i am 32 and have been on antidepressants since i was 17. zoloft worked well for me for many years, then i spent quite a few more years trying different things until i tried pristiq. i don&#039;t remember how long it took to start working, and i haven&#039;t had any miraculous weight loss, but i feel like a stable, happy, normal person on it, and that is enough for me. the one warning i will add, if i miss even a day or two i have serious withdrawals. depression, obsessing, lots of crying and just generally coming unglued about anything and everything. this is not how i feel or act when i am not on medication, it is definitely a withdrawal, so take with care."