"i have suffered from severe depression for over 3 years, mood swings, irritable, loss of interest, huge lack of energy, absolutely no motivation, anxiety, paranoia, and panic attacks. i was prescribed 100mg extended release 2 times daily and its amazing how quickly it works. i don&#039;t have nearly as many mood swings as before, i have tons of energy (once you are on wellbutrin you realize just how much depression really affects you without even noticing it), tons of motivation. (i used to debate whether i should do this or that now i just do it there&#039;s no question whatsoever). however it did not help my anxiety or panic attacks, the side effects for me were a very annoying twitching and dry mouth. i have only been on it for a week so time will tell."