"i was taking bactrim ds prior to spironolactone (50mg 2x/day) and clindamycin from november to april, but i started to build resistance around march and i waited until it just stopped working. i recently went to my dermatologist about a week ago and from the large painful cysts all around my mouth and chin he told the pa and myself to prescribe me spironolactone as it is hormonal. i wish i had gone on this sooner! the persistent cysts are shrinking and drying! i had an initial breakout (still have a little) but i am keeping a positive attitude which helps a ton. this will be the medicine that cures my acne of 9 years, i just know it. i&#039;m glad my dermatologist stopped talking about accutane with me, this is a much safer alternative if you have persistent hormonal acne."