"i was prescribed vyvanse to combat daily fatigue caused by autonomic dysfunction. it treats those symptoms very well, but prolonged use has a large impact on my mood and personality. by the 2nd week, i was feeling very sad all day every day. a strange side effect that i encountered was that it made my armpits quite literally drip with sweat. the only other bothersome side effect is that it initially kept me up until 5/6 am, but that was remedied with 0.1mg clonidine before i went to bed. i&#039;m sure this medicine works very well for those with add and adhd, as that is what it is designed for. if you are looking for a solution to chronic fatigue caused by autonomic dysfunction, you may want to consider other options."