"low estrogen is a very common thing in my family. i told my doctor about this, and she prescribed tri-sprintec, because it has triple the amount of estrogen found in women. if you don&#039;t have low estrogen, and you are using tri-sprintec, of course you are going to experience unpleasant side effects such as acne, mood swings, weight gain, etc. i&#039;ve been taking it for over a year, and my family says i&#039;m a much more pleasant person to be around now that i have something ridding me of my terrible mood swings. i can effectively lose weight while taking it and have little to no acne. i went two months without it and gained weight, also breaking out in acne. "