"insurance required me to use opana er crush-resistant version!  takes about 2 hrs. to take effect so i take hydrocodone/acetaminophen 10/325 with 1 opana upon waking and together they last about 8 hours never 12 hours!  then take 1 hydrocodone/acetaminophen about 4 pm then another hydrocodone/acetaminophen about 9 pm then 1 opana at 11 pm.  i tried using opana alone but couldn&#039;t stand waiting in pain for 2 hours before i could feel any relief!  regular oxycontin did provide 12 hour relief without needing any vicodin for &quot;breakthrough pain&quot; but even with insurance it would cost $100/month.  pain level with opana and vicodin still at about 5 but chronic pain after five hip replacement surgeries - 2 on left hip, 3 on right, since 2008!!"