"i have been on pain medicines for over 10 years. i&#039;ve tried it all. i was taking oxycodone 2 x 80mg plus 2 x 40mg plus 6 roxicodone 30mg a day. my pain doctor switched me to 2x40 plus 2x20 opana plus with the same roxicodone a day. this helped some. i had built up a tolerance to oxycodone. last month she changed the roxicodoen to 4x10mg opana for break through pain.  now i have my life back. this is the first time in years i have been able to get up and get around. i have had a pain pump before and was going to get another one but after this switch as of now i don&#039;t need it. if opana is not working you may need a higher dose if you are able to take it. don&#039;t give up. "