"i&#039;ve had 2 back surgeries for herniated disks.  the second surgery wasn&#039;t successful and i have constant nerve pain along the right side of my leg all the way to the ankle.  ms contin er has helped a great deal.  i take 45mg every 8 hours.  i also take ms contin immediate release for breakthrough pain (15mg up to 4 times a day).  all in all, thumbs up."