"just start on 5 oct at 278lb - been tracking food and exercise in fitnesspal. minor side effects that pass quickly. i asked doctor for this as it contains buprion which i was on nearly 16 years ago. i lost weight while on that and was able to maintain for some time. due to lifestyle changes, stress, bad foot and age (51 now) i gained a lot of weight in the past 10 years and have been trying so many different ways to get control back but was not having success. since being on contrave i feel more focused don&#039;t need to snack between meals and am already down to 272.5lb. i really hope i have the success some other have had - good luck to everyone whose fighting to control their weight it&#039;s hard for some of us but not impossible"