"i was on lexapro for about 2 years until  itstopped working. prior to that,over the last 25 years was always on an antidepressant. you name it, i&#039;ve tried it. what the antidepressants  did for me was just take away the severe irritability that i had, i was really at a low point when my doctor asked me to try brintellix. i had no desire to do anything.  i felt no joy. i had been taking 40 mg.of lexapro a day. doc said i didn&#039;t have to wean off it.  he said i could just switch, starting the next day and i did. i started on 5mg for the first 2 wks then increased to 10mg it&#039;s only been 4wks that i have been on it and my nausea has got better, i have a clarity in thinking that i didn&#039;t have before. i feel joy now. i am staying on it.  also, no sexual problems on it. got hope!"