"i have suffered from depression off and on for years and have taken zoloft in the past. this time it didn&#039;t seem to be working. i also was hit with overwhelming anxiety because of my husband&#039;s job difficulties. the doctor prescribed celexa a couple of months ago. after 3 weeks, i was ready to give up on this because it took longer to kick in than zoloft. i also had terrible dry mouth and food just didn&#039;t taste good. but the doctor bumped me up to 60 mg and that really did the trick. i only have dry mouth when i first wake up in the morning and food tastes good again. my hubby said that on zoloft i was more &quot;flat emotioned&quot; but on the celexa, i have the normal ups and downs that everyone else has. the only negative is that i am on the tired side, but not terribly bad. it is a lot better than wanting to jump in front of a bus. i urge everyone to give this a try and stick with it. good luck!"