"i have tried over 20 different medications, and trintellix is the best fit for me. i always describe its effect for me as &quot;being able to turn everything down in my head.&quot; i can see how this might not be a good fit for others as it might certainly aggravate &quot;feeling nothing&quot; or &quot;feeling detached.&quot; however, as my issue is primarily that i feel too much and am unable to step back from my emotions and intrusive, racing thoughts, trintellix&#039;s &quot;detachment&quot; is extremely helpful for me. 

i do get nausea for the first week upon taking trinellix or upping my dosage; however, this subsides for me. i was on 10mg for 8 months and have now increased my dosage to 20mg in hopes of it being even more effective."