"i took roaccutane 9 years ago at the age of 30. although i didn&#039;t have cystic acne, i had had persistent facial acne since the age of 12, and nothing helped. initially the drug helped a lot, with the major side effect being severely chapped lips and dry skin. after several months of treatment my dose was increased. within days i was depressed and miserable, with crying spells. it took me a while to put 2 and 2 together and consider the medicine as a likely cause. i dropped the dose down again and i quickly improved. however, i feel the damage was done and i gradually became more and more depressed and ultimately was taken of the medicine. for the past 9 years i have suffered depression and anorexia nervosa."