"i have tried just about every medicine there is to treat bipolar disorder, and seroquel hands-down is the best one for me in terms of stability. however, the weight gain has been a problem. i gained 40 pounds on seroquel. the good news is i&#039;ve lost 16 pounds of that in 3 1/2 months. it&#039;s been hard work, but i am confident i can meet my goal of losing 48 more pounds over the next year."