"i&#039;m taking 300 mg bupropion and still extremely depressed.  psychiatrist gave me a month of 5mg samples of brintellix to supplement the bupropion.  i have been taking it for 5 days now and have severe nausea &amp; vomiting along with constipation. nausea &amp; vomiting occurs 20 min. to 1/2 hour after taking so the drug isn&#039;t absorbed into my system to have an effect on my depression.  i am on other medications that i was taking at the same time as the brintellix.  i&#039;ve decided to take the bintellix with food in the morning and all other meds at night due to the vomiting so that the other drugs can be effective.  i can deal with nausea &amp; constipation, but the not vomiting. i will continue taking and hope the vomiting stops. fingers crossed."