"i am on day 15 of taking contrave. i took one pill/day for the first 10 days &amp; have been on 2/day for these last 5. days 1-6: gnawing headache at least once/day; insatiable thirst; significant constipation. during that time, i had decreased appetite, but i think that may have been due to the constipation-there is just nowhere for the food to go! after &quot;clearing&quot; things out with miralax i have a more normal, healthy appetite. no urge to binge and know when to stop. when i started 2 pills per day, i was again very thirsty, which is better in the last day or so. no headache with the increased dose. down 2.4lbs, but i haven&#039;t exercised at all, so &quot;only&quot; 2.4lbs in 15days is perfectly fine with me. i look forward to seeing the long-term results."