"i&#039;ve dealt with major depressive disorder for 22 years and have always had to be on several anti-depressants at one time. they only lessened my symptoms in the best of cases, but did nothing most of the time. i&#039;ve been on every antidepressant in addition to things like risperdal as an adjunct. i was on 450mg welbutrin, 60mg remeron and 120mg cymbalta concurrently with no effect when i decided to take the maoi plunge. that was 18 months ago. it&#039;s truly amazing to feel normal. i&#039;d forgotten what that felt like.

i do have to say the first couple of months were the most brutal med adjustment i&#039;ve ever been through. very glad i hung in and didn&#039;t give up."