"i have been on depo for 11 years now. i had about a month of spotting when i got my 1st injection, but i have since stopped having periods altogether. it has not affected my sex drive. i have gained a little weight, but that could also just be the fact that my metabolism has slowed since i&#039;m getting older.  in the last year i have had a little bone loss and my doctor now wants me to switch to something else. she has suggested implanon. wish i could just stay on depo. "