"i have been on pristiq for 2 weeks now and was prescribed this medicine for severe depression and anxiety. to be honest, i am not sure if i feel any positive benefits or not. i do know, pristiq has done nothing for the anxiety which has pretty much ruled my life for months now. i am hoping eventually this medicine will help me deal with the anxiety. i do have a small dose of xanax to be taken as needed but, i would really like to avoid taking it. as for side effects, i had the nausea initially, not so much now. i do notice i have to be near a bathroom at all times due to frequent urination. weight loss has not been significant but, i lost a lot prior to taking this medicie and haven&#039;t gained so, that is a plus."