"i&#039;ve been on this medication for bipolar i for over a year now. recently i&#039;m experiencing a bit of bipolar depression with irritability and anxiety, so my doctor has increased the dosage from 40 mg/day to 80, but i&#039;m titrating up at 60 mg this week. i also take lamotrigine at 75-100 mg/day and i already notice a positive difference, so i think it&#039;s fast-acting, which i initially noticed when i was first put on over a year ago (i posted a review here in june 2012). some minor side effects for me are increased tension in the jaw area."