"i used duac after being prescribed it for a good six months (on repeat prescription). to begin with, my skin flared up bright red and it dried my skin out terribly. i then reduced the amount i was using from the fingertip amount which is recommended on the box to the merest bit on each area of acne. this worked a treat, and within 2-3 weeks my skin was looking much better. over the next 6 months or so, my skin improved and i only had a small break out once in a while. however, i felt that after using it for 6 months, my skin had become accustomed to it and i was having more and more break outs. i stayed off the cream for a good four months. i am now back on the cream, and going through the phase of the skin drying out etc."