"i have been taking pristiq for 3 weeks now. first week, a mild headache, and insomnia, but after reading forums i would take it early in morning, and sleep improved. this is the first antidepressant i have taken. i felt wonderful, and thought wow this is what i have been missing! things that bothered me before, became insignificant. week 2 much of the same. week 3 i feel tired and slightly flat, much the same as i did before.  i had an anxious moment but distracted myself and it passed. first time i actively felt anxious. i will continue to see how it goes. having feel the amazing, stable, elevated mood in the begining makes me consider riding it out."