"i have dealt with depression stemming from an incident in my profession.  i was initially on zoloft for about 1-2 years.  it worked ok but after a while not so much and all i got from it was that zombified &quot;what&#039;s the point of life anyway&quot; feeling.  i switched to pristiq and it was much better.  it cuts the depression but doesn&#039;t give you that blahed out zombie feeling that the ssris can do.  i don&#039;t have much of the side-effects luckily.  i have noticed it takes longer to ejaculate (but i think my wife sort of likes that part of it- sorry for too much info). anyway pristiq is a great medicine.  i noticed some people here had bad experiences with it.  i think that&#039;s to be expected with all antidepressants. keep trying and find the right one."