"i started contrave on may 18th and i am down 13lbs!! i am so excited about that. i have not been exercising but have significantly cut down my calories and fat intake. today i start my second week and should be starting my second pill, 1 in the am and 1 in the pm. however i&#039;m going to stick to one pill for another week or so. in the beginning, i would say the first 3 days i did have nausea and a headache. my head hurt for 3 days straight! i really thought my body wasn&#039;t going to tolerate the medication. the nausea wasn&#039;t was tolerable but the headache seemed to start off light and then by around 5pm i swear it felt like it had its own heartbeat! but the 4th day i woke up and i felt normal again. i will be checking back in a week or so."