"so my journey has been two years with depression/anxiety.  had two bouts prior.... the first coming out of nowhere around age 40.  the two times i went on a paxil and in 30 days i was normal.  you can only imagine my disbelief when this third bout trying lexapro, effexor and paxil lead to horrible fatigue within a week of each.  i just couldn&#039;t tolerate the fatigue and there was no relief.  incredible.  went on 100 mg of wellbutrin despite it increasing my anxiety... requiring lorazepam.   for past year i couldn&#039;t tolerate more than 100 mg of w. w/o terrible fatigue.   a year later i just got up to 150 mg without fatigue... no relief of depression yet.  also in therapy.  wellbutrin is better than nothing i guess.  not sure what&#039;s next."