"i was on this med in 2010 for a year. the dose went from 25mg up to 400mg. the first few weeks were very difficult. it knocked me out cold and i had such a blocked nose i could hardly breathe. i toughed it out and my depression lifted. i stopped taking it because of really bad blocked nose. i have just had a major depressive episode (2015) with insomnia. i was prescribed 100mg. it worked within 24 hours. i was able to sleep for 9 hours and feel refreshed and energized. the depression and anxiety have improved dramatically. this time i&#039;ll stay on seroquel."