"i have the same problems as many of the other reviewers. my medication was changed from avaine to lutera to orsythia. i had no problems with avaine or lutera but i&#039;ve been on orsythia for about a week and i&#039;m experiencing horrible side effects. i&#039;ve had headaches, moodiness, and cramps. it feels exactly like i&#039;m pmsing and according to other reviewers, i just might be. i&#039;m glad i came here so i can be prepared for a possible mid cycle period."