"at the suggestion of my obgyn, for recurrent vaginal yeast infections that seemed to come 2 weeks after every single period for no reason. i decided to do the depo shot to keep my hormones high and potentially stop my period to hopefully end the yeast infections. i am rating this a 5. the yeast infections stopped, so it worked in that sense. however, the side effects are horrible! weight gain, acne (always near the end of the 12 week mark when you&#039;re due for another shot ) and i&#039;m talking cystic acne, horrible horrible acne. i&#039;m 32 and my skin looks like i am going through puberty every time my shot is about to run out. i also get it on my back. never before did i have that issue. sex drive decreases. and, around the 12 weeks mark migraines"