"after 1 week receiving the shot. i had night sweats for 5 days. i been having severe anxiety. my body aches like i have  the flu it will be one month i&#039;ve been on depo the night sweats r away but i&#039;m having pain in my feet and in my knees. the odd thing is instead of gaining weight i&#039;m loosing weight i lost so far 12 lbs in almost a month. i&#039;m starting to spot due to my period always comes on the 20th. not getting cramping yet.  i&#039;m not going to get depo again because the night sweats n leg pain n some minor headaches i don&#039;t like. i&#039;m 31 yrs old and a mom of 4. my husband says since the shot he noticed me more down n not in the mood. so i&#039;m certain the depo is causing all this craziness to my body.i&#039;m getting blood work done to c if its my thyroid"