"i have been on brintellix for 8 months. it has been life changing for me. i feel it literally saved my life. i have been on more medicines than i can count over the past 15 yrs. i did have nausea pretty bad for the first couple weeks on brintellix but taking the medicine at night with crackers and sprite it was much better after about 2 weeks. now here is the hopeless part... i have to go off the medicine due to severe side effects that i do not see others reporting. about 6 months into taking brintellix (4 months on 10 mg and 5 months on 20 mg)i got severely sick with unexplainable internal bleeding and severe gastro problems.thousands of dollars on medical testing and nothing found.2 days off better but mental disaster.terrible withdrawal"