"day 3 of pristiq....was just on cymbalta for 4 months, and it was wonderful and then i got really anxious all of a sudden and angry so we switched. prior to that i was on celexa, paxil and prozac over 20 years. am 50 year old female with two sons and husband. have not noticed any change yet. anxiety is gone, but i don&#039;t feel &#039;positive&#039; change, more neutral.  i take at night as prescribed by my doctor. i sleep well. i am more hungry now than when i was on cymbalta and am worried i will gain back the weight i lost. midday i get a tingling in my forehead and thirsty. am tired. hope to feel some really positive results over the next few days, as others have posted. time to have my life back."