"i bought this gel a few years ago and stopped using it as it wasn&#039;t that effective on my skin. however recently i started applying this along with a few other products and it was great. for me, i find it most effective when i apply it twice a day on the painful cystic pimple (normally on my nose). i wash the acne prone areas on my face with a wash that has salicylic acid 2%, then use a toner with witch hazel or a cotton pad soaked with pure green tea. i apply retinoid, let it sink in and then i apply epiduo on those areas. i think it&#039;s important to use it as spot treatment if you&#039;re overly sensitive like me. if you&#039;re feeling dry i apply a cream with hydrocortisone over it at the end. my pimple bump disappeared in two days."