"i have been taking bactrim for about a year and a half now. prior to bactrim i took everything else. i&#039;ve had acne since i was roughly 15 and am now 23. everything i took either left me feeling crappy, or didn&#039;t work. in my experience taking bactrim the first 2-3 months my face breaks out horribly. then at some time in that period it just goes away. it is absolutely the best acne medication i&#039;ve ever taken! i have taken it twice."