"my doctor replaced prozac with pristiq in hopes it would be more effective in fighting my depression.  at first i thought i was in heaven.  i&#039;m in my late 50&#039;s and never felt this good ever.  i also lost 30 lbs!  as time passed, i became more and more manic. (not a feel good manic either).  had to get off of it.  shame.  when it was working for me it was better than anything i&#039;ve ever tried."