"i started contrave on feb 5, 2016. it took me a minute before i actually began to use the medication because i was nervous of the side effects.  during that time i weighed 240 pound wearing a size 18 pant size.  after speaking with my physician who&#039;s also a weigh specialist informed me that the side effects will be minor and will not last long.  once i began the medication, taking one a day for the 1st week and 2 for 2nd; increasing the dosage until i was on 2 in the morning and 2 at night.  i did suffer mild headaches and dry mouth during the first 2 weeks it went away and i have been doing fine ever since. as of dec 27, 2016, i can joyously say i am 201 pounds wearing a size12 pants."