"doxepin is the fourth medication that i have been prescribed for my insomnia. prior to doxepin, i had taken melatonin (as many insomniacs begin with), trazodone, and seroquel. i do not remember any noteworthy effects from the first two, but i was amazed with seroquel. it worked like a charm once i fell asleep. however, it often took me far too long to fall asleep and i felt extremely groggy, sometimes for hours, when i woke up. still, i was very satisfied, having finally found something that brought me some much needed rest. when i switched doctor&#039;s, though, i was switched to doxepin. i have only taken it for a short time, but i cannot praise it highly enough. it takes effect far more quickly and has less grogginess than seroquel (for me)."