"i would rate this medication a 4. it did clear my acne for about 9 years- i took it while i was in high school. i am a petite, small female and may have been perscribed too high a dose. i experienced thoughts of suicide (extremely out of character), depression, very dry skin, aggrivated acne and scarring that was much worse than i ever had. this medication should be prescribed very carefully and should be a last resort. patients s/b monitored closely while on this."