"was prescribed acetaminophen/tramadol for migraine pain after traditional migraine medicines actually worsened my pain...it really helped..a strange sort of relief though...can still feel the actual pounding but it just doesn&#039;t hurt after i take the tramadol! i am used to it now. usually take 1 or 1/2 a pill 2 or 3 times a week...although was prescribed to take every 4 hours as needed. oh also, i was having a problem with frequent diarrhea and that is gone now too! i get itchy skin when i go several days without them but not so much that it really bothers me."