"i&#039;m taking duloxetine 20mg per day for anxiety and minor depression. i have taken this med for almost two months and keep a daily journal. as a &#039;blind study&#039; i started this drug without my wife&#039;s knowledge. i noticed a decrease in my overall anxiety in ten (10) days and my wife mentioned my calmness in two weeks. i am a 70 year old male and i supplement duloxetine with buspar on an &#039;as needed&#039; basis for anxiety. the duloxetine seems to smooth things out without the numbing effect of a benzodiazepine. i&#039;m on the minimum available dosage and will soon ask my pcp to up my dosage to 40mg per day. there have been absolutely no bad side effects from the drug."