"i have cystic fibrosis and severe back/neck pain. i needed a stronger medication due to the cystic fibrosis and found that percocets just made me extremely nauseated. nucynta can be taken on an empty stomach, and while i experience slight tiredness that was about all. however as time progressed i discovered that it became somewhat less effective and i had to bump up to 10s. when this happened i started having pronounced muscle spasms and issues with regulating my body temp. also there is no generic so i averaged about $117 per dose. overall i was pleased with the medicine.  "