"i give it a 10 and i would give ssri&#039;s and snri&#039;s only a 5. it&#039;s our first experience with maoi&#039;s and its still early days. but what a difference with fatique (none). other side effects in our case are minimal or non existent. i wonder what % of people actually notice severe side effects (maybe less then 20%?). it appears that maoi&#039;s are well known these days. i presume it&#039;s because they are old generic drugs (not covered by active patents) and hence will not get high advertising budgets from the pharmaceutical companies. i also presume that many gp&#039;s have no knowledge of this class of drugs or these are too risky, adverse (side effects) to recommend a trial. it took us at least 7 years of battling depression and fatigue before we found out!"