"i  started  wellbutrin er a few months ago for depression. i had no energy and wanted to do nothing.  it has helped so much with the depression but my hands tremor.  i tried cutting back to once a day and couldn&#039;t tell much difference in the tremors. i asked my doctor to give me the xr (150mg)  so that i could take it just once a day. i  felt like i was going to jump out of my skin. i could even feel my lips quivering.  i like that it makes me feel better but don&#039;t like the tremors. i can&#039;t find anything documented as to whether they will go away in time or continue as long as i take it. i haven&#039;t taken it today and i have no tremors."