"well had many changes or should i say increases in medication as i seem to only get 12 months benefit then medication becomes less and less effective. regarding  quetiapine i was on 60mg a day. 9 months ago i started to become ill again. i became suicidal. so saw my psychiatrist. he  said the current thinking was 600 to 800 mg of quetiapine.  was the effective dose to take for bipolar. so now i am on 600mg every evening. i am back to being well and have been for many months  the only side is effect is relaxing of muscles, talking like a drunk.so to take it early evening,and go to bed  once i start feeling drowsy,"