"i&#039;ve been on just about every antidepressant on the market and my doctor and i decided to try adjunct therapy with seroquel to &quot;boost&quot; the effect of the brintellix i take. i was really pleased to find it has a significant effect on my anxiety, which has always been a major component of my depression. while it didn&#039;t get rid of my depression, i feel better overall than i have in ages. 



downsides? it&#039;s expensive if you don&#039;t have good insurance. i get a 90-day supply for $80. it also will knock you the heck out. i have to take mine before 6 p.m. or i will have great difficulty in waking up (even with an alarm). it has a heavy sedating effect."