"i&#039;m one of those unlucky people that doesn&#039;t really respond to antidepressants, so i need an antipsychotic to stabilize my mood.  i was on seroquel for a many years but switched after the negative effects of my memory and concentration, which ended up being not so subtle; weight gain and oversleeping came a little while after as well, so i found it was time to switch. this is my best try so far after seroquel, but that&#039;s not saying much.  having to take this with food   needing to go to sleep pretty much right after or else getting lost in a paranoid/anxious frenzy/limbo-type state is really quite challenging. i also get tired pretty early which i believe is due to the half-life of the medication (18 hours or so)"