"i&#039;ve been taking kadian 60mg 2x day for severe back, knee, hip and hand pain. i have a failed knee replacement from 10 years ago and have been taking kadian ever since.  controlled pain mostly but also taking norco 10/325 two pills 3x day for breakthrough.  just yesterday my pain doctor increased the kadian to 80mg in the morning and 60mg at night.  i can&#039;t imagine what my life would be like without the pain relief i get from kadian.  i tried fentanyl patch with no relief (then i heard of the deaths caused by the patch), and tried oxycontin and again no relief, so kadian is for me.  only issue is it is extremely expensive."