"i have tried almost every medicine you can think of for bipolar 2 with horrible side effects.  seroquel, lamictal, depakote, lithium, abilify, trileptal, topamax just about everything like i said and either had hives, rash or just could not tolerate them.  my new doctor gave me saphris and within three days i felt better than i had in 15 months.  after three weeks at 10mgs a day once a day i almost feel like my old self again.  this is a miracle as far as i am concerned the only side effect that i have is feeling weak slightly winded when i walk or exercise. don&#039;t know if anyone else feels this or not.  it does bother me because i can&#039;t keep up walking or in pilates class like i used to."