"i have only been on seroquel xr for about a week at 50mg. my doctor prescribed it as an adjunct to remeron to treat anxiety, depression, paranoia, and insomnia. i also take gabapentin, atenolol, and xanax. when the seroquel xr works, it works. i can feel it sedating me two hours after i take it. i&#039;ve been sleeping eight and nine hours a night, which has not happened in a very, very long time. it&#039;s effective at neutralizing both anxiety and depression. but... it doesn&#039;t last 24 hours for me; it only lasts about 15. once it wears off my anxiety and depression return with a vengeance. makes for a very rough 8 or 9 hours until i can take it again."