"i&#039;ve been on the depo shot for over three years now i was so happy to get rid of my period. i&#039;ve had none of the side effects that people have mentioned such as depression, migraines or loss of libido actually i think it increased mine haha but the only thing that i&#039;ve noticed was the weight gain and it was only maybe 5lbs a year so it wasn&#039;t that noticeable. the only thing that i&#039;ve noticed is that as you are ending the year and getting your first shot for the new year you tend to bleed irregularly for a week to two weeks but i&#039;ve had nothing but positive things from this shot."