"i&#039;ve been taking tri-sprintec for about 3 months now and i haven&#039;t had any real problems with it at all. just some breast tenderness right before my period and cravings every now and then. i used to be on loestrin 24 fe and i had the worst side affects with it. i had severe mood swings and depression which lasted for the entire 4 months i was on it. after getting off loestrin, i went on ortho tri-cyclen lo and didn&#039;t have any problems with it, but switched to tri-sprintec because it&#039;s cheaper. i was afraid that i might have the same negative side effects with tri-sprintec that i had with loestrin, but i haven&#039;t and that&#039;s just awesome to me! it&#039;s best to not judge a pill within the first week of taking it. it takes a few months to adjust."