"does cause mild nausea at first and also when changing doses but i take it night and usually slept right through it, it only lasts an.hour or so. other than that i love it. i was feeling hopeless, stressed, accussing my boyfriend constantly of being negligent. i was taking prozac before and it worked but made me tired and i blacked out when i drank. with brintillex i skip it if i drink and have plenty of energy and no issues. i felt good just a couple days after taking it but that subsided then a couple weeks later the &quot;cloud&quot; of depression just sorta lifted."