"i have had chronic lower back pain/degenerative disc disease for over 25 years, along with an l5 s1 diskectomy, my pain and my condition continue to get worse with time. in the past i have been on oxycodone, hydrocodone, fentanyl, and just most recently, oxycontin 30 mg time release, did not like them at all. even more recently i was prescribed hysingla 80mg time release. i have been taking it for two days now and i am amazed at how i feel when i wake up! no pain, and slight withdraw, at which point i take a 10 mg oxycodone for breakthrough pain. it&#039;s been forever since i have woken up happy. don&#039;t notice any side effects yet, can say, that it certainly does not last he 24 hrs.... more like 12-14, and takes a few hours to start working..."