"norco 10/325 has worked well for me. i started using vicodin 500 mg, which i got immune to very quickly. my doctor switched me to norco 500 mg. also got immune to this. so they put me on norco 10/325 and i haven&#039;t had any problems since then. they work wonderfully. i take them every 4 hours. that&#039;s been 2 years ago."