"i was on zoloft for two years. i started taking it after i had a panic attack due to extreme stress. it worked well for me. i tried lexapro for a few days maybe 9 to be exact and i couldn&#039;t function. i couldn&#039;t lift my head or have the strength to care for my son who was a baby at the time. zoloft was amazing. i stayed on 50mg and felt normal again. but with that said, i did gain 30 pounds. the medicine makes you feel so relaxed as before i was a calorie counter and obsessed with what i ate. i didn&#039;t mind much because i was better, that&#039;s what mattered. i came off of it and decided to get back on 5 months after stopping. i can say the second time around of being on it doesn&#039;t work for me. like others, i must have become immune to it."