"i have been taking zoloft for about 7 years after a serious bout of depression. i began on a 50 mg dose and was recently upped to 200 mg. it helped with depression, but left me feeling very &#039;numb&#039;. i started taking pristiq about a month ago. i feel more normal than i have in years. i have experienced no side effects. i know everybody is different and not all ssri&#039;s or snri&#039;s work the same for everyone, but pristiq has definitely helped me feel better than i have in a very long time. it&#039;s worth a try."