"i&#039;ve been on zoloft (generic) for a few weeks now. i&#039;m on a low dose (25mg) to get me started. i haven&#039;t noticed much of a lift in my mood, in fact i tend to get sad more easily, but i have fewer headaches, which used to be a big problem for me. also i&#039;ve noticed it makes me really tired so i take it at night to help me sleep."