"was prescibed nucynta 100mg initially. it took effect within approx. 1hr. i, too, felt loopy &amp; out of it. i felt i was hallucinating and had strange off the wall kind of &quot;dreams&quot;. so i called dr back &amp; exchanged the prescription. i had asked to try the 75mg but guess i scared dr with my symptoms. so i was prescribed 50mg.  i have been on this dosage for 4 days. doesn&#039;t last long enough and does nothing to manage my pain. i have spinal stenosis as well as scoliosis and degeneration of discs (virtually no discs) between l1-l5. osteoarthritis in knees as well as in lower back. this medication works well on some, not so with others. "