"i have now been on pristiq for a month, by the way it takes that long for you to see a difference.  this is a good medicine. calming, gives me a happy feeling upon waking. a general sense of well being.  i am bipolar. have been on everything for the last 30 years. i kept going back to prozac because it kept me skinny.  i do have to watch my weight with this drug but you won&#039;t gain if you don&#039;t increase your eating."