"i&#039;m coming off the depo soon, hoping the withdrawal symptoms aren&#039;t as bad as i heard. initially the shot made me bleed for the first shot, 3 months, then it abruptly stopped. if i didn&#039;t get the shot right away, it caused some pretty awful mood swings if i didn&#039;t get it the first day possible. lost a bit of weight in the breast area, went down a bra size due to the shot. otherwise, no significant weight gain. no periods is a big plus! but mood swings are pretty bad."