"i&#039;ve been taking a very low dose of seroquel (1/2 tab, 12.5 mg i think) off and on for several months now, for anxiety, depression and insomnia (off-label).  it is the most effective sleep inducer i have every taken.  the problem for me is that the effects lasts for about 36 hours, not just 8!  the whole next day is low-energy, although it is also low anxiety.  so it is good when you absolutely need to recover sleep or take a break, but i cannot use it on a regular basis at all and continue to function at work etc."