"i have been using these off and on for years. best relief after using as directed for about 48 hours, using a new patch every 12 hours. this medication is for inflammation so it takes a little while for swelling to subside enough for pain relief. i use along with oxycodone and muscle relaxers and honestly think i get more relief from the patches. they are just so expensive i can only fill my prescription once my deductible is met for the year and even then i have to download a coupon. my cost for a full month is about $70. much better than almost $600!"