"i have been on zoloft for about 6 weeks. i was experiencing depression which manifested itself in crying spells, anger, helplessness and loss of motivation. it took approximately 4 weeks for me to notice any changes,  but i have noticed recently that i have motivation once again and i have not experienced any side effects which i was dreading such as loss of sexual desire and weight gain.  i feel like my normal self again and able now to handle the issues of my life  prior to this i was sad a lot and having many crying bouts.  i haven&#039;t noticed any negative side effects whatsoever."