"viibryd is the only anti-depressant that really worked for me. i tried prozac, zoloft, effexor. i&#039;ll never know if those 3 medicines didn&#039;t work but the effect was subtle at best. viibryd&#039;s impact was unambiguous. so much so that after the 3rd week i felt that 30 mg would be sufficient. my doctor advised me to go ahead and take 40 mg and that is my current dosage. note that i was diagnosed with co-occurring anxiety and the action of viibryd is such that it is a very effective anti-anxiety medication, at least for me. note that some people report an increase in anxiety with viibryd at higher dosages."