"i have been on many different antidepressants from the age of 15 till now (22). i have tried wellbutrin which was decent, zoloft, lexapro, effexor etc. now i am on pristiq 100 mg and couldn&#039;t be happier. all the years i&#039;ve been trying to find what works for me, i finally have. my only complaint is that if i even forget to take it one night, within 10 hours i feel awful! shaky, sweaty, brain zaps, rage etc. as long as i remember to take it, it&#039;s an amazing antidepressant."