"i&#039;ve been taking advil (ibuprofen) since 1999 for headaches and body pains. i sometimes take this with the prescription medication maxalt (which treats migraines) i&#039;ve have really bad headaches and migraines since i was in grade school and took tylenol until when into my late 20&#039;s. i then started taking the regular 2 tablet dose, 400 mg. i have on occasion upped the dosage (not on doctors instruction) to 600mg if the 400mg dosage isn&#039;t effective and the pain doesn&#039;t not subside within 30-45 minutes."