"i was very skeptical when my lifelong dr retired, and my new doctor wanted to switch me from ms contin to methadone, for my la pain med. i had never heard anything either way about methadone as far as pain, it is just associated with opiate detox, and replacement therapy, and i did not like the thought of being prescribed it. to my great surprise, the 10mg four times a day, worked miracles in my life, with very little, to no noticeable side effects. really helped the pain, didn&#039;t make me feel doped up or itchy. he&#039;s since sent me to a pain specialist, i&#039;m now on the &quot;high powered&quot; stuff e.g. opana er, doesn&#039;t really help much. on 40mgs tid. don&#039;t know what the hype is over the opana, doesn&#039;t work that great for me, and for relieving my pain"