"i took effexor xr 150mg for a good 10 years for depression.  then, i switched to zoloft due to what is considered a side-effect of effexor:  elevated liver enzymes.  on zoloft, i felt more anxious than i did on effexor, but not overly so.  it was tolerable.   i continued to have same liver enzymes while on zoloft.   it turns out the enzyme issue is not related to the medication alone, if at all.  i had a stressful life changing event and felt very anxious.  i know i felt much less anxious on effexor so i asked to be switched back and i was.  the doctor made a general statement that he wants me on what works best for me.  however, i&#039;m pretty sure he didn&#039;t buy my anxiety theory. "