"when i first started using epiduo (roughly 2 years ago) i really struggled with dry, red, cracking skin. i was worried about the reaction and read a lot of reviews, many of which said &quot;the redness and dryness stick around for 3 months and after that it works perfectly&quot;. in my experience, this was exactly right. after 3 months of the dry, cracking skin, my skin had adjusted and i had far fewer (and less severe) breakouts. at the time i was taking doxycycline which eventually became ineffective and i&#039;ve since been on the contraceptive pill for roughly 1.5 years. epiduo is excellent for preventing small, bacterial pimples and my skin is noticeably worse when i don&#039;t use epiduo for a while."