"i&#039;ve been on zoloft for 3 weeks (100mg) and it&#039;s done wonders for me.  i was always sad, uninterested in anything, quick tempered, very negative...you get the picture.  within a week that changed.  i&#039;m able to laugh, i want to do things again; best of all, my sex drive is returning!  my appetite has lessened, but i&#039;m not complaining.  in the first week, i was taking zoloft by itself; now i&#039;m taking seroquel xr in the evening in conjunction.  i&#039;m sleeping like a baby the night through (first time in years, really!).  my family and friends are as glad as i am that i&#039;m now on the right track."