"i&#039;m taking this in combination with zoloft. i take 0.25 mg of klonopin (half a pill) twice a day. it&#039;s a very low dose, but in combination with the zoloft has been effective at managing my anxiety. i was originally taking 0.5 twice a day but that was making me too drowsy to concentrate on work. overall this is a great med for anxiety, especially when waiting for an ssri to start working."