"i take wellburtin xl 150mg and pristiq and have been since 2009.  tried to go off of pristiq twice because my sodium level is a bit low.  within a month of being off of pristiq i got my old anxiety attacks, panic, insomnia, etc., so the positive definitely outweighs the negative.  hopefully, my sodium will be corrected now that i&#039;m seeing a specialist for it, but for me pristiq and wellbutrin xl work wonders and i don&#039;t plan to go off either ever again."