"i have been on zoloft several times. the only side effect was the &quot;runs&quot; which is fine you can take anti-diarrhea medication.  i am also on epilim, i was recently diagnosed with bipolar which in itself is a good thing.  no antidepressant worked for me, i was always low.  and off them i was both hyper and low.  it was horrible, then the anxiety kicked in.  so that&#039;s why i am glad to be finally diagnosed as at least i can get help and proper treatment.  zoloft is brilliant for anxiety, but it didn&#039;t stop the bad lows and i was so tired. but no side effects whatsoever, well only the runs - which you learn to live with."