"these have saved my life, i&#039;ve been on the patch for 3 months, 25 mcg, every 48 hours. i think maybe one more adjustment will do it. keep in mind they are to be used with a breakthrough medicine also. well since i&#039;ve been on patches i forgot about pills. still have to take them though. i have 6 year old boy i can play with him again. that means the world to me. give them time to work, and it took 3 adjustments to get them right, it took 6 weeks, three 2 wk trial periods. word of warning my doctor went on vacation during trial period, i had only been taking them for a month, the withdraws were very bad. as soon as he got back i couldn&#039;t wait to start on them again. that says a lot. you have to plan ahead with these meds. call 4 or 5 days before refill."