"it&#039;s a wonderful knock out punch if everything else has failed, or if you&#039;ve taken something like ambien and it stops working. for me ambien was great until it stopped working, i then tried trazodone but that didn&#039;t help much. seroquel is an antipsychotic but at small doses (25-50mg) it only hits histamine receptors so its like a large dose of benadryl- but much better then benadryl. only downside is that it is a little hard to get out of bed the next day but you will sleep like a bear so it&#039;s worth it. takes about an hour to an hour and a half to kick in and 25 mg does the trick for me. also, there is no weight gain at small doses so that&#039;s nice too."