"my liver has always looked fine on ultrasounds.  since i&#039;ve been taking seroquel (4 years)  my liver is enlarged, fatty and dense. however, i have been on various anti depressive meds for 35 years and the liver has to process this every day. it also made me drowsy. don&#039;t know if seroquel made my liver this way or just all the years on meds. i am currently coming off seroquel and onto lamictal and rexulti. fingers crossed! good luck to you all, it&#039;s a very tough condition to live with!"