"been taking 100mg for around 6 months now for depression and anxiety. i felt an almost immediate effect from pristiq, did have trouble getting to sleep for the first 10 or so days and felt weird and spaced out a bit but nothing bad. i now feel great, i have a clear head and great concentration. i&#039;m a lot more social too. i&#039;m much more relaxed and look at life in a positive way. stick with it, its the best medicine i have used by far."