"i had been on seroquel since 1997 and had gained a lot of weight.  i also had the side effects of type 2 diabetes, high cholestoral, etc. from taking it so long.  but seroquel worked for me.  so in an effort to loose weight and the &quot;bad&quot; side effects i switched to latuda.  lutuda didn&#039;t do squat for me in the sleep department, so i ended up taking a half pill of seroquel and a dose of latuda.  this worked well for about a year.  i lost a ton of weight and my overall health improved.  however, i slipped into a major depressive episode in less than a year and had to go back to the &quot;tried and true&quot; seroquel.  feeling better, but gained back a lot of weight.  never thought a drug marketed for bp depression would make me depressed."