"i&#039;ve been on zoloft for about two weeks now and i&#039;ve noticed a considerable difference in my demeanor. the very first day i took it, it upset my stomach severely. i was so nauseous and had intestinal issues...yikes. but the next day i felt great. my doctor recommended i take a half pill for the first few days. i have had some relationship issues and work issues and i suffer from anxiety and depression. i have obsessive, negative thoughts about my relationship and it was seriously impacting it. i was fighting with my partner everyday because i couldn&#039;t stop thinking about our problems. since i&#039;ve taken the medicine, we had one fight. i do sleep a ton though i seem to be shaking that off a little. i feel like so far so good."