"my dr. just put me on hysingla er about a week ago. i take them faithfully every morning at 10a.m. and every morning i wake up with withdrawals.  i have to take 2-4 hydro&#039;s besides the er during the day for breakthrough pain, when i wake up in the morning, wow!!! my heart races, my palms are sweaty, extreme anxiety.  i&#039;ve been having to take a regular hydro in the mornings before the hysingla er just to tolerate the withdrawals &amp; pain!  maybe being that it has only been going on 1 week since starting that it&#039;s wearing off before the 24hrs. not sure, but i know this never happened with oxycontin.  will have to wait &amp; see, if not better by my next appt. i am definitely changing medications."