"my internist prescribed me 25mg of zoloft daily as an alternative to wellbutrin. the side effects were not worth the benefit for me. in the seven weeks i faithfully used the med i suffered from severe fatigue, inability to orgasm, weight gain, acne, and chest heaviness. as a thirty-something, in-shape mother of two, i have zero time for naps so, fatigue was not a livable option for me. i&#039;m actually really surprised by the weight gain as i hit the gym daily. the pros of this medicine would be: my sweet tooth was non-existent. that&#039;s probably it."