"i just finished a package of safyral yesterday, and so far i&#039;ve had no weight gain, my acne has cleared up some, and my period came when it was supposed to. however, i have had spotting all through the first month, which the doctor said was normal so i have no complaints other than one really big one. while being on this pill i have had serious depression. i&#039;m always moody, crying and sad. i am so sad that i have no appetite, no desire to go out, i&#039;m never happy. in fact, i get raging angry sometimes and i can not control any of this. i am hoping that this side effect goes away soon."