"i can not longer use imitrex or related drugs for migraine pain due to heart issues. in searching for an alternative migraine treatment, my doctor prescribed indocin. alone indocin can&#039;t relieve migraine pain, but combined with midrin, i get relief. i&#039;m in the midst of weekly migraines.  they had been reduced with midrin, but still lasted days.  now, combining the two, i can break the migraine cycle."