"i just was put back onto wellbutrin after attempting 3 other antidepressants.  it was only after being off it that i realized how good it worked for me. i was taken off of it because it caused me to have some issues with irritability and according to my family- short tempered.  i was put on cymbalta, but i enjoy a drink or 2 a day with my wife (cymbalta and alcohol will destroy your liver- very well documented).  zoloft made me feel completely despondent, and i felt life was no longer worth living, not to mention made me not even remotely think of sex.  when i was put back on wellbutrin, i felt like life was worth living, and i feel happier and euphoric.  now i take lamictal with wellbutrin 150 mg in the morning.  avoid the xr- causes insomnia."