"i tried 40 mg of this medication for about 8 weeks. initially (1st 2 weeks) it seemed to work. then, for the last 6 weeks, it seemed not to work. i had side effects of tummy pain, leg cramps and irritability. my doctor insisted i was getting better and just needed a higher dose. so she put me on 80 mg of this medication. i began to experience extreme bursts of anger and negativity, which of course only worsened the depression. i also had horrid stomach pain and couldn&#039;t tolerate it. after going off the medicine, i felt much better. no expense, no leg cramps, heart rate down, rage bursts abruptly stopped after about a week. yay, i guess. back to amitriptyline..."