"i having been using epiduo for over a year now and i haven&#039;t had any bad experiences with it. i had mild acne and this cleared it up really quickly. now the only acne i get is hormonal and i put the epiduo on at night, almost using it like a spot treatment and the spots are already almost gone the next morning. it comes in a fairly small bottle and i have to get a refill every few months it seems which is the only downside."