"started taking this pill yesterday (11/19/17) and about 2 hours after taking it felt extremely nauseous and tired. came home and took a nap. felt better when i woke up. definitely noticed a difference in appetite. wasn&#039;t hungry for anything. in the evening, i did recognize the cravings were coming back, but i steered clear of sweets. woke up today with a horrible headache, not sure if it&#039;s related or not, but leery to take contrave again today because of headache. will update later. but so far it is reducing cravings and can tell when it wears off. i&#039;m sure when i ramp up to pills in afternoon, it won&#039;t wear off."