"on prozac (lovan) for 4 years, felt it was no longer helping and read about a type of antidepressant that targets your neorephrine (noradrenaline) re uptake, not just seratonin. mentioned it to doctor, he recommended pristiq but i had to stop taking the prozac for a month before starting pristiq (hell.) thought i made a terrible mistake as it didn&#039;t start working for at least 3 months. difference is prozac inhibits you from feeling emotions whereas pristiq allows you to feel and be able to deal with them. no side effect but if i miss a dose in morning by lunchtime i&#039;m so dizzy and lightheaded!"