"after having my second child i had severe post natal depression. counselling and group therapy didnt help all. six months later i started on 50mg pristiq, then 100mg after 2 weeks. at first side effects were quite full on. i took pristiq in the morning, was full of energy. then after lunch time, i was unbearably tired and had to have a nap, even for 20 mins. i just could not stay awake. i tried to take it at night but then i couldn&#039;t sleep. so, i stuck with taking it in the morning. the tiredness effect didn&#039;t last long, maybe a month? at the start there were also headaches but they soon subsided after about a month. it helped to take pristiq with a full cup of water. i have been on it for a year and a half now and feel so much better."