"effexor xr 300 mg has really worked well for me.  although, i am gaining weight.  i previously lost 50 lbs and now it is coming back on.  my doctor thinks it has something to do with all my medicines that i am on for depression, ptsd, anxiety disorder, just to name a few.  i am hesitant of trying a different medicine, but i can&#039;t keep on gaining the weight.  it is too hard on my back."