"i too started pristiq after 17 years of being on antidepressants. i also have tried everything out there. i did not feel anything at all for the first 2 weeks. however, i started to have these slight body aches - never did i attribute this to the medicine. after another week on this medication, i also could not stay awake for longer than 2 hours at a time. i began having body aches. i could not make it through a day at work, i could barely get out of bed in the morning, and there was no way i could do my household chores. i had many blood tests ran and everything came back normal. i finally realized it may be the pristiq and after just 3 days of being off of it, i was completely pain free and not tired."