"i was originally on prozac 20mg for my depression.  i found the prozac helpful, but emotionally numbing.  i am participating in psychotherapy and it got to the point that i couldn&#039;t really access my feelings and it was interfering with my therapy. i spoke to my doctor and he switched me to pristiq 50mg. i found that it was easy to adjust to (some nighttime sweating but that&#039;s about it).  it gives me very good control of my depression.  my irritability is also very well controlled.  however, i am now able to access my feelings when i need to (such as in therapy) and i feel less numb. i am still able to manage stress just as well as when i was on prozac, yet i don&#039;t feel so disconnected from the world and from myself."