"for me, contrave was my last chance before surgery. i started out a 300lbs, and yesterday i weighed in at 249! the first month the nausea was awful. i was almost ready to give up when i found someone that suggested dramamine. i take one dramamine every morning and the full 4 pill dosage of contrave with no more nausea.  other side effects for me have been almost constant constipation and very light sleep. one thing i want to make very clear is that contrave doesn&#039;t make you lose weight by itself. it gets your mind in a place where you can do it yourself. it puts you in control, instead of the cravings. i have lost 50lbs, and i thank contrave, but i still worked my ass off to get here! "