"i use to be on 800mg of morphine instant release. withdrawal was immediate (4-8 hours) if i ran out or missed my doses, usually it was the latter. as it was easy to increase dose without major side effects, i was always taking more rather then less and having to lie to my doctor about why i was always early. finally went to detox 3 times and then started methadone. my highest dose 120mg, now 105mg, which works well for my pain."