"this cream is very and very strong, this is perhaps what many do not realise. i don&#039;t have a very sensitive skin but i had mild acne and my doctor proscribed a daily use of it. i applied before going to bed and after there second application my face totally broke out and it looked as if i had burnt my face fighting with fire, my patches were enormous and it would itch and burn. i discontinued after the third day and saw my dermatologist who proscribed monovo to fight the side effects and skinoren to apply instead of epiduo. i wish i had read this thread before actually starting with epiduo. i had to take extra unplanned holiday because i couldn&#039;t go to work with a tomato red face."