"i almost never experience major side effects from any medications, and i have been off and on many antidepressants over the past 14 years. i was taking zoloft for a couple months, which was helping with my depressive symptoms, but i though it might&#039;ve been giving me sexual side effects, but i wasn&#039;t sure so my doctor suggested trying trintellix. he said it has a lower incidence of sexual side effects.  well, not only did trintellix give me horrible sexual dysfunction and even lower libido, every time i took this drug for two weeks, i literally felt like i was coming down with the flu about 15 minutes later.  headaches, nausea, vomiting, heartburn, feverish.  i really do think this stuff is poisonous, and needs to be pulled from the market."