"i&rsquo;ve been on loryna for a couple of years now (maybe 3 or 4?). i absolutely love this pill for controlling my acne. it is the only other thing besides daily antibiotics (doxycycline) that have controlled my acne. i tried sprintec prior to this and it did nothing for my acne. short term, i have had no side effects from loryna. no weight gain, no extreme mood swings, nothing. my only complaint and reason for considering switching is that after taking this long term, i recently developed spider veins on my thighs. i have never had such a thing so it was very concerning as i am only 25 and in very good health, and as i know there are increased risks for dvt while taking this drug. recently the areas on my thigh where the spider veins developed have become somewhat painful at work (as i stand all day). i attribute the development of the spider veins directly to loryna as this is only medication i have taken the past couple years. it is such a shame because i absolutely love what it has done for my skin (flawless even during the time around my period), but the veins cause a large concern for me so i am heavily considering switching. 
overall, i love loryna for the shorter term, however if you plan to be on it for a few years, it may be concerning.

i also know someone else who was on gianvi (another generic for yaz) and the same thing happened to her regarding spider/varicose veins."