"i took propoxyphene several years ago for a neck ache and had good luck with it so when i developed a moderately painful shoulder pain that wouldn&#039;t go away i asked my doctor for it again. i am limited to what i can take for pain because i take anti-coagulants but propoxyphene does not seem to affect my prothrombin-time. it reduces my pain with no side effects that i have noticed. i only have taken it for short term use though, so have no long term experience with it."