"i have suffered from depression for about six years now. i am a female and about to turn 22. i was put on zoloft because i recently began to experience severe anxiety over little things. walking around campus terrified me. i couldn&#039;t go through drive-thru&#039;s or phone someone i didn&#039;t know. my mood swings were becoming ridiculous and i had been having more obsessive suicidal thoughts. i started zoloft 50mg and everything was wonderful for a month then it wore off. i slipped back into severe depression. i just started taking 100mg and feel so much better! the only side effect i have experienced are a little insomnia, slight loss of appetite, random hand twitching, and some forgetfulness. i finally enjoy life and don&#039;t want to just give up."