"i took one dose. i had no reduction in pain compared to norco 10/325, 2-3 a day. in fact, i had more pain. terrible side effects including a spike in blood pressure, headache, felt woozy, rapid pulse and what i believe to be an anxiety attack. it was a nightmare and all i could do was wait for it to finally ware off. i have impaired kidneys so it took 36 hours to leave my system. horrible experience!"