"i&#039;ve been taking effexor xr for 15 months for treatment of depression.  initially, i wondered if there was a point and if it was making a difference.  i was very skeptical when i ran out during a storm, didn&#039;t receive mail, and my mail service pharmacy prescription arrived late. i felt like my head was &quot;sloshing&quot; and i was very sick to my stomach.  missing a dose was awful.  but about a year after i began taking it, i noticed that i was back in control of my life and i felt like me but better than i remembered.  my friends say they saw a difference much sooner.  i don&#039;t know if the passage of time, monthly therapy, or the medicine is what helped me get my depression. i&#039;m giving credit to effexor xr."