"i tried taking the depo shot and i was on my period for 6 months straight. i told my doctor who suggested yaz.  i have been taking it for 4 years and here are the things i have noticed after a long term use. tiredness, spotting, weight gain (went from 105 to 127) but then again that&#039;s not as bad as it could be. i have stayed active taking kick boxing and running. appetite increase- since taking it i have felt like i should eat and eat and eat. "