"i am at the end of the 2nd week of the starter pack, last 20 mg pill.  i feel so much better on this medicine. my depression started after some horrible things happened in my family and it paralyzed me.  i didn&#039;t want to do anything anymore.  i wanted to be left alone.  i finally feel happy again.  i have been on zoloft.  that worked but i gained too much weight. effexor didn&#039;t really help and wellbutrin did nothing.  this one made a huge difference and quickly.  i had diarrhea the first day of each new dose but it quickly went away.  no other side effects.  i am also sleeping much better.  the bottom line is, everyone is so completely different.  it is all trial and error."