"i am into my 4th week of pristiq and it hasn&#039;t yet kicked in.  i still require a clonazepam every morning for the anxiety when i get up.  the wild dreams have finally subsided as have the sweating.  i was on zoloft for 10 years which worked wonderfully for me until it quit working. i tried celexa - didn&#039;t work, tried effexor xr - didn&#039;t work and had a lot of side effects with it.  pristiq is supposed to be from the same family as effexor so possibly this may not work.  one can only keep hoping."