"i have been taking saxenda since march 1, 2016.  in the last 5 months and 1 week, i have lost 48 lbs.  i started out at 268 lbs and am now at 220 lbs.  this medication has been life changing for me.  the only side effect i experience is constipation.  i try to combat this by drinking lots of water and taking senokot at bedtime.  if anyone has better suggestions for this, i&#039;d love to hear as this is my greatest struggle at the moment. i give myself the injection at night before bed.  my goal is to lose another 40 lbs before i re-evaluate where i am with the medication.  my appetite has drastically lowered, so i find i really need to ensure i&#039;m making smart choices when eating, like adding healthy fats to give me more calories."