"i&#039;ve been on this medication for about 9 years for bipolar, even after all that time i still suffer from the exhaustion i need to sleep 12 hrs every night any less and a few days later i have to sleep for 14 to 16 hrs to catch up so it pretty much rules my life in a bad way but it has more or less stopped the manic [has or at least made them less severe, dosn;t help with depression. after six years off work i&#039;m trying to go back but everything has to be planned around taking quetiapine, i can&#039;t drive after taking it and i need to take it about five hrs before i want to sleep so nights out are a no no as i&#039;m too groggy the next day. if i miss a dose i literally cannot sleep, my jaw tightens and i get anxious, i take 600mg"