"i have fairly severe anxiety and depression, as well as some insomnia. i&#039;ve only been on this medication for a few days. i have tried lexapro, buspirone, zoloft, gabapentin, trazadone, and topamax. i was on lexapro for about three years and it worked wonders. all of the others either had little to no effect or had terrible side effects. i am now coming off zoloft and starting remeron (mirtazipine) combined with effexor xr. although i have not been on it long enough for it to improve my mood, i have noticed that it makes me feel almost zombie like. it helps me sleep, but i have to force myself out of bed and i am constantly tired throughout the day. i am going to give it some time and see how it goes."