"i&#039;ve suffered severe depression for the last 20 years. i&#039;ve been on zoloft, paxil, prozac, wellbutrin, effexor, celexa, cymbalta and lexapro. my neurologist prescribed pristiq 2 months ago. i recently told her at my follow-up visit, &quot;for the first time in 20 years, life doesn&#039;t suck.&quot; i wake up in the morning well-rested. my mind is clear. when i go to bed at night, i&#039;m actually tired (no more insomnia!) and i sleep really well. i used to be a stress eater; now i only eat when it&#039;s meal time and have less of an appetite. the only negative side effect for me has been constipation, but it&#039;s manageable. i had pretty much given up any kind of hope that feeling better was possible. i&#039;m glad i was wrong!"