"i have been in a major depression for 3 years, and possibly a minor depression before that , i also have anxiety and social phobia,  i have been on sertraline for almost two months now, and i noticed an enormous difference the first few days, i started to smile, laugh, make eye contact, and the fear of public is slowly easing !   i can not describe how bad life was before sertraline.  i am 34 years old and have been living a life that wasn&#039;t a life at all, now i am feeling better than i have ever felt.  i do get dry mouth !  but, oh to laugh again!  (worth it). i am usually not a person who even uses tylenol ,  so for me to try this, i was desperate .  i don&#039;t feel high nor drugged or even out of my body!  i feel whole"