"i was diagnosed with bipolar ii about 5 yrs ago and i&#039;ve tried everything on the market nothing worked for me except seroquel. right now i take 300 mg twice per day and i&#039;m so stable. i&#039;m loving it problem though with seroquel is that its a major weight gainer. i would stop taking it on and off when i felt better but then would use other meds to bandage my symptoms...get back on then off again...until one day i decided to stop with the denial and allow someone to help me for real. i&#039;ve been on it now faithfully for 9 months...but i&#039;ve put on 60lbs! it makes me eat after hours in the middle of the night. i&#039;m depressed because of the weight gain. so i workout at home at times trying to be more consistent. you have to work this medicine."