"saphris has been a literal life changer for me. i have tried antidepressants in conjunction with mood stabilizers such as lithium and depakote. i was combating severe depression and mania. when i first started saphris, i was suicidal and had awful thoughts constantly. nothing was working. i was on 1000mg of depakote, which was as high as i could go due to my low body weight. my psychiatrist, who was the 4th psychiatrist i had seen in 6 months, added saphris to my regimen of depakote, 30mg of remeron, and 10mg of ambien for sleep. within just a couple of days i felt great! all the bad thoughts disappeared, i no longer want to die, and this medicine did not take away my (manic)creative energy like most other antipsychotics do! miracle for me!"