"i have been using this medicine for 5 weeks. i started on 20mg at night. physical side effects included excessive sleeping, dizziness on waking (lasting about 2 hours), substantially reduced libido, teeth-grinding and no appetite.  other side-effects were a feeling of &quot;disconnection&quot; from my emotions, forgetfulness and repeating tasks.  so, whilst the medicine alleviated the depression symptoms, it was impacting substantially on other aspects of my life.  however, i revisited my gp and requested a reduction.  i am now on 10mg per day.  the difference is phenomenal - i feel hopeful and able to cope, still don&#039;t have an appetite or &quot;normal&quot; libido but can work round those issues! i guess it&#039;s all about finding the correct dosage for you."