"i was on the depo for about 2 1/2 years, and after some initial spotting (about 9 months) i loved it. super easy, nearly painless, very effective. if it weren&#039;t for the bone loss controversy, i&#039;d still be on it. i didn&#039;t notice any side effects, my period was replaced by light spotting about 3 weeks before i was due for my next shot."