"after 10 years of having nearly every ssri&#039; and snri work and then fail, i developed sertonin syndrome on a cocktail of both. i was so afraid to try any antidepressant...but my depression became life-threatening.  i&#039;m on only 50 mg. of lamictal (going slow!) for a month...and i am becoming cheerful!  amazing.  i do have a slight facial rash i&#039;m carefully watching.  no other side effects."