"i have been on bupropion sr 150mg twice a day for a few weeks now. at first i had weird feelings (side effects) very hot..a little trembles..nothing that i couldn&#039;t deal with. dr. wanted me to take 1 pill twice daily after the third day. i did and it was horrible..so i remained taking the 1 pill until my second week and it was perfect. no side effects or weird feelings. oh besides always being thirsty nothing major! i like the meds and i&#039;m a much happier person unless i forget my second pill...then i&#039;m back to my old grumpy rude self! good luck to anyone starting this medicine!"