"i have injured my back several times over the course of about 12 years. i have tried everything under the sun. i am currently on the 5mg er 2 x daily and the 10mg ir 3-4 x a day for breakthrough pain. like many people have said you have to take it on an empty stomach. this medicine works better than any other. as long as you take 2 x er and 3-4 ir&#039;s for breakthrough per day you will have the best results. i am due for my er&#039;s to get increased but other than that this is the best pain management i have ever had."