"i love this product. i&#039;ve tried everything under the sun for my cystic acne. epiduo is the only one that worked. i&#039;m using it in addition to clindamycin lotion and doxycycline and have been using it all for about 5 days. i noticed a difference in my skin the very first day. i am experiencing some dryness and mild redness upon waking in the morning but nothing a little neutrogena lotion with spf couldn&#039;t handle. also i would recommend drinking lots of water if you&#039;re on the regimen i am. need to stay hydrated while using these medicines. believe me, i&#039;m a registered medical assistant. if epiduo didn&#039;t work, i wouldn&#039;t be on here saying it does."