"i had a lot of side effects on effexor 37mg- dry mouth, constipation, increased heart rate and blood pressure, ringing in ears, nausea, shakiness, more anxiety and so on. i don&#039;t remember having all these with lexapro or zoloft a few years ago. at least not to the same degree as effexor and if there was any side effects they went away after a few weeks. i switched back to zoloft 25mg after 3 weeks and 3 days in i already feel better - no more feeling wired or jittery. effexor is not the med for me. it did help the depression, but the crazy side effects aren&#039;t worth it to me. i do have a friend that&#039;s been on it awhile and it work great for her."