"i started off on 5mg they had no effect so gp upped to 10mg. by the second day the pain had reduced substantially and things felt good. i&#039;ve suffered for eight years with sacroiliac pain s1, herniated discs l4/5/6 at base. just had successful total hip op. however i&#039;ve had to come off them due to the very bad side effects, nausea, crawling itchy feeling under the skin,unable to sit in the sun and if i did suffered greatly, irritability, very low mood, and worst of all hot flushes. i&#039;m back to my old self now. when peps start telling you you&#039;ve changed, it&#039;s no joke and was very relieved to get them out of my system. having said that, i know they work for some."