"i was taking regular trazodone on and off for a couple of years, it stopped working so my doctor switched me to desyrel. it&#039;s a good pill for the fact that it does make you tired, but i&#039;d make sure you&#039;re gonna get 8 or more hours of sleep before you take it. i was prescribed 100mg pills, and i only took half of a pill whenever i took it, and i had the hardest time waking up the next day. also, with the reg trazodone and with desyrel, it took a long time for it to kick in for me (2  hours), but that might be because i have a high tolerance to pills. if you&#039;re new to this medicine, take it on the weekend, or whenever you can sleep in, so you can see how it works."