"i have been taking zyprexa for about 5 years. started at 5 mg and am now at 2.5 or 1.25, depending on the day. this is for bipolar. i&#039;ve tried to go off it (because i felt dulled and had a preoccupation with food) a few different times and had severe depression/anxiety symptoms recur. i also take prozac (20mg) and lamictal (100 mg). i don&#039;t think the lamictal does anything but the zyprexa seems to be the &quot;glue&quot; that keeps me together. weight gain was an issue but have recently lost 20 lbs through diet and exercise (and reducing dose). i would rather not have to take it but it so greatly improves my quality of life that i feel i should stay on it."