"i was on 200 mcg of fentanyl patchs, and 100mg of ms contin 3 times a day and 30mgs of msir (instant release morphine) 3 times a day for almost 7 years for these horrible migraines i have constantly. these medicines were not helping anymore after being on them for so long. about 6 months ago i changed doctors who switched me to opana er. i am taking 80mgs every 12 hours along with 600mcg fentora 3 times a day for breakthrough pain. i have not had any side effects from the opana at all which is wonderful and i can function daily and not be laid up in bed constantly. i would definitely recommend opana er but just think about something for breakthrough pain in case it is needed."