"i started depo provera im after the birth of my son. i never had regular monthly periods before so the injection completely stopped my period while on it. i went off it one year to attempt another pregnancy and it took almost a year for my period to return. i went back on it after deciding against a second child. the only issue i had with the im injection was a heightened feeling of irritability/anger and soreness at the injection site for a day or two. when depo provera was switched to sq it alleviated any irritability the day after. i&#039;ve only had good experiences with depo provera."