"i&#039;ve been on tramadol 50 my 3x day for 7 years now for arthritis. it&#039;s a very good pain relief it also helps sleep good an helps with my anxiety issues. but my tolerance level started to get high after a year of taking it. it stop working good so i had to start taking four a day, then ended up finding out i&#039;m having withdrawal symptoms which is very terrible thing to go through. i suggest if anyone taking this... *warning* if u feel like it not working anymore and you&#039;ve been taking it for a long period of time stop taking them that means your getting addicted. or just take a break from taking them for a bit. went through hell with the withdrawal from those."