"i had cancer and went through a year of treatments .. the chemo threw me full force into menopause... and just when i thought i was getting back to normal...i had major depression and awful anxiety.  it was very debilitating - i was angry and crying all the time.  i started on 50mg of pristiq and it helped slightly within a couple of days.. the anger went away, they upped my dose to 100mg and almost 6 weeks to the day...it was like somebody turned the light switch on.  i had no side effects at all and best of all i feel completely normal not drugged or off center...just great!"