"it worked almost immediately ! i had my dosage moved to two tablet twice a day and then back down to one tablet twice a day for every twelve hrs. the only thing is i have a difficult time with regulating my body temperatures. when i get hot i get really hot and it takes awhile to cool down. when i get cold i get really colds and it gets hard to get warm again and so on. i&#039;ve had the twitching of the arm and hands as well and i have been nauseous. but really it works ! i just still deal with being hot and cold at times."