"i was put on zoloft a few years ago when i became very depressed (i also have anxiety and have had it pretty much my whole life which made it worse) and i&#039;ve been on it ever since. i feel much better now about myself and my perspectives on things however i don&#039;t know if it was from the drug, time or therapy especially because i was finally feeling more in control of myself and my thoughts last year. so if it was zoloft then it took a while for it to kick in for me i guess ? my doctor did say that in some patients it does nothing and in others it does so who knows ! however whether it&#039;s working for me or not i feel good right now and it&#039;s not having any long term side affects on me so i can stay on as long as i want "