"i haven&#039;t taken this rx for long but it definitely is *not* the best option if you have no breakthrough meds. i&#039;m on 30mg which is to last 24 hours. i&#039;d say it does for 18. it&#039;s not horrible but i do think people will keep complaining until they are on a higher dose. the oral bioavailability of this drug is actually lower than norco. i take norco 10/325 tid and combined with the hysingla it&#039;s not the worse... but i feel little relief during the day. it does however help me a bit at night. i think docs need to give higher doses than what they are of this med because it&#039;s a 24 hour med... 30mgs in 24 hours is not a lot. well, at least i have my norco 10/325 to help. also, i think this med would work better if taken twice daily! but not the worst med!"