"i am not able to use oral contraceptives containing estrogen, as i have migraines with auras (which puts me at a highly increased risk of stroke). as such, i have been getting depo-provera shots for the past 2 years. i have not gained any weight at all while on the shot and my weight has remained extremely constant. i stopped getting periods altogether after the second shot and have had very light spotting only a few times (lasting less than a day). my only issue is that my sex drive has decreased slightly, but not severely enough that it has significantly affected my relationship with my boyfriend. i think the shot affects everyone differently, but for me it is the best option available and i have not had many side effects using it."