"i started taking seroquel about 10 years ago. i have to take about 600mg a night plus ambien to get a good nights sleep (this is as prescribed by my doctor). i don&#039;t know what i would do without it. it changed my life when i realized what a good nights sleep could do. my depression improved just by sleeping better. i&#039;ve never had any terrible side effects. i do tend to have to eat after i take it as it seems to make it work faster. i did have a small amount of weight gain (5-10lbs) but nothing like when i tried zyprexa (30-40lbs)! seroquel is definitely something you should ask your doctor about!"