"i&#039;d been on wellbutrin/wellbutrin sr for over 15 years and it worked great until about a year ago when i started feeling i&#039;d built up a tolerance to it.  seeing that aplenzin was basically the same, but in hydrobromide form instead of hydrochloride, i figured it would &quot;trick&quot; my body into reacting to it as a new medicine without losing the benefits. with the blessing of my psych doc, i switched and it appears to have worked.  i&#039;d give 10 stars, except for the high cost."