"i&#039;ve tried many antidepressants before, and this seems best and with least side effects. i have been prescribed it along with duloxetine, and this combination seems to be excellent in reducing anxiety and depression to almost zero. i now take 30mg mirtazapine before bed, and 60mg duloxetine in the morning. i also take 0.25mg pramipexole at bedtime to curb the restless legs syndrome and help with libido. this way sex life is not hampered by the duloxetine. there is initially a period of adjusting to meds, weight gain, but i have so much more energy to exercise so i&#039;m fit now. well recommended. starting dose for mirtazapine was 15mg, and for duloxetine 30mg."