"very effective from the beginning! although i came across a few side effects - redness, dryness, peeling of skin - this cream completely eliminated most of my acne. i particularly found it astonishing that over the space of a few months my cysts had decreased - in size -dramatically. they&#039;d shrink and leak until they vanish usually not leaving any scars, only marks - which will fade over a period of time. when my skin was feeling painful due to the side effects - stinging at night - i&#039;d stop using duac for a couple of days and moisturise up. once the side effects decreased slightly i&#039;d go back on it. i took duac along side the antibiotic erythromycin - however i didn&#039;t find that drug effective."