"i have been on cymbalta for 3 weeks now and i feel great. it started working within 48 hours. i am not depressed at all. i have more energy. i feel like me again. the first few nights i had problems staying asleep but it is better now. no negative side effects yet. sometimes it curbs my appetite but i always over-ate anyway (i&#039;m about 20 lbs. overweight) so i think this is a good thing."