"i have only been on seroquel 25 mg for just over a week. so i cannot say if i will experience the weight gain or not. but so far this is the best thing that&#039;s worked for me. i was horrifically depressed and anxious for over a year, and before that moderately. but after just 1 days on the seroquel i felt a huge difference. my thoughts had slowed down, my anxiety and depression got cut in half, my appreciation of time and continuity came back a bit, the disassociation was appeased. for the past year i felt like i was on one giant bad paranoia trip, and only after i started taking this medicine did i feeling normal again. there are still major things that are a problem, but the seroquel makes it way more manageable."