"i have been on depo now for about two years and have had nothing but negative side effects. the only positive thing about depo provera is that you don&#039;t have to worry about missing a pill. i&#039;ve suffered major headaches, weight gain, mood swings, hot flashes, irregular bleeding, cramping, breast pain, and change in sex drive. i thought this would be a great option for me because i wasn&#039;t always on top of taking birth control pills. after trying depo out for two years, i have finally decided that all these symptoms are not worth it. if you plan on getting the shot, do your research and know the symptoms that it comes with."