"have been on depo for about 9 years now and have no periods. when i first started depo i was bleeding for about a month til it just went away. 

probably gained some weight, i feel the depo has me very moody and also makes me feel tired, it gives me lots of nervousness but surely prevents pregnancy, i&#039;m not sure that it&#039;s safe to be on depo for a long time because it can cause weakness in bones, so consult your dr on how long you should use it."