"i was so very excited when i found out that i could be helped after being diagnosed with mthfr, i was on deplin 15mg a day, i actually felt fantastic after about 2 months of treatment, after about 8 months i slowly started getting severe muscle pain and weakness also extreme joint pain as to where i could barely work or do the slightest of activities. doctors ran a ton of blood tests but found nothing, i recently stopped taking deplin and have found that the issues have disappeared! i loved deplin and am very sad i can&#039;t take it any longer! it really also helps with depression and mood!"