"male, mid 30s, depression for ~10 yrs. was on cymbalta 60 mg qd for 2yrs, wasn&#039;t working, depressed, so up&#039;ed to 90 mg qd. didn&#039;t work, had typical side effects. cross tapered to brintellix over 3wk period achieving 10 mg qd dose. felt good for 2wks - more energy, sharper mentally, but very angry and irritable. then all &quot;good&quot; effects ceased; all i felt was continual anger and irritation, which worsened every day for 3wks. put on 12lbs/1mo while being on brintellix. stopped 10 mg dose cold turkey for 1wk, just started on fetzima. can&#039;t tell if brintellix withdrawal or fetzima, but now having sexual aes, namely near spontaneous ejaculation without being erect or stimulated - any other men have this with either drug?"