"as one of the reviewers who posted feeling &quot;different&quot; on day 1 or 2 on pristiq, i am now on it for 10 days and i have been very tired up until today.  from day 2-8, i slept a good 12 hours daily which is hard to do with kids lol!  but today i woke up feeling good and immediately made beds, put on coffee and whipped up a great breakfast.  this may not seem like &quot;a big deal&quot; but for me, who was lying in bed crying for 8 or so weeks, it&#039;s a huge change and i hope it continues. 

i have been waking up frequently at night but it&#039;s not that bad as i can fall back to sleep easily.  as i said in another post, i was on another antidepressant for almost a year and it was horrible.  the hardest part was saying yes to the help offered.  good luck to all."