"i took cymbalta for 1 year. it did help with my depression however, i became very lethargic and gained 25 lbs within 3 months. the weight gain scared me because i had never gained that much in such a short period of time. also, i did have serious constipation with cymbalta. if you can handle the wieght gain and constipation, i think cymbalta is the medication to at least try, it does work-or it at least worked with my depression."