"after 20 years of every ssris for depression and generalized anxiety disorder i have found that gabapentin is the only medicine that has really helped the anxiety with the exception of thioridizane (now withdrawn in uk). at first seroquel seemed to help but 3 months now on gabapentin and significantly better. still haven&#039;t found the ideal dose (now about 2400 a day) but initial side effects have worn off. my family say that since coming off seroquel my personality has returned to what it used to be years ago. give it a good try, and good luck. if you post on here i do think it helps if you mention dosage (and body weight 224lbs)."