"i have been taking sertraline for quite some time now (over a year) 100mg. pros have been that i have been a lot calmer, not having panic attacks and less weepy and anxious. unfortunately there have been some side effects which wont go away - i suffer from headaches a lot, extreme tiredness (am tired all the time - despite having 8  hrs sleep, etc.), i have no desire for sex and i have gained weight (though suspect the weight gain is more down to the tiredness and me attempting to get energy through food). on the whole though i&#039;m happy with it."