"bipolar with mixed episodes, adhd and severe anxiety. saphris was a miracle for me also. i&#039;ve been on disability for 10 years and this is the first medicine i&#039;ve taken that has made me functional.  absolutely can&#039;t take it the morning; it makes me incoherent for about 3 hours and i eat everything in sight.  so i take all 20 mgs at night and am doing fine.  have mouth sores, though. my doctor said to alternate between taking it sublingually, supra lingually and but ally and it&#039;s helping. "