"i started spironolactone for acne in april and started out taking 50mg a day and i will say for the first three months i thought it wasn&#039;t working (i was still getting a lot of cystic acne breakouts around my chin and mouth). but i figured i would give it some more time because my body may still be adjusting to the other medications i&#039;m also using with it (derm also put me on orthotricyclen birth control to help with acne as well as differin cream twice a week) i stuck it out and noticed a drastic change in the fourth month and i&#039;m now on month 5 and have had no breakouts for a month straight! i also lost about 8 pounds since i started on the medicine! which was a great bonus. i recommend sticking it out!! it takes time but it really works!"