"i was taking lexapro 10mg then upped to 20mg for the past 5 years. in the beginning it was great, i felt great, no anxiety or depression.  but for the past two years my everyday life started to become a struggle. i became upset easily, i cried all the time, it was horrible.  so my dr and i decided that maybe the lexapro had pooped out and to try a different antidepressant. so i began sertraline 50mgs. i&#039;ve had no side effects except for some heartburn right after taking. so i began prilosec to counteract this. i feel good. no anxiety and i can feel my depression lifting. i sleep fine no problems there. but i do take 25mgs of vistaril at night so i&#039;m sure that helps. "