"am 61 male. tried all ssri&#039;s and maoi&#039;s for persistent depression over 9 years. most recent was prozac. none of these worked beyond moderate improvement. depression and anxiety attended me constantly. i used lorazepam to sleep effectively. i went on brintellix 10 mg and within 2 weeks felt stable and able to deal with challenging personal setbacks with clarity and resolve. i think that 4 months into it i have found a drug that truly works."