"i am a 47 yo male who has been on 100mg of pristiq for 2 years.  first on 50mg then increased.  i found i was sleepy for the first few months but nothing compared to the original symptoms like depression, anxiety etc.  my only concern is the withdrawal effects.  on one occasion, i went to pharmacy on saturday and they advised i needed a new script.  i had to wait until monday to get a script and they were the two worst days in my life....the withdrawal was chaotic, i argued with the chemist in a rage....never done this before...i called them an hour later sobbing and apologising for my behavior, i had awful flashes in my eyes and headaches that made a migraine feel like party.....i was frantic at the doctor on the monday morning"