"phentermine works great for weight loss. i&#039;ve taken it two different times. i lost 30 pounds in 2 months the first time. the second time i lost 10 pounds in a week but had to discontinue use due to side effects. i had postpartum depression the second time and it made my depression much, much, much worse, and i had horrible &quot;phen rage&quot;. i would definitely suggest talking to your dr if you struggle with depression before starting phentermine."