"i have suffered from depression on &amp; off since childhood as i had gone through a lot of trauma in my childhood. i believe my brain was rewired due to the depression i&#039;ve endured since - that first started when i was 9 yrs old. i&#039;ve been on about 14 different antidepressants of all types (including maoi &#039;s &amp; mood stabilizers &amp; none of them had really worked for me. i gave up on everything - &amp; truly believed i&#039;d just had to accept wanting to die almost daily for the rest of my life!!! i finally asked my dr. if i could try any new antidepressants &amp; he prescribed pristiq. 
this is the start of my 3rd month on it &amp; it&#039;s changed my life! i&#039;m actually feeling wonderful &amp; have found hope again! on 50mgs/day."