"i have been on this medication for roughly two years. before i started trintellix, i was on zoloft and it caused me to gain almost 40 pounds in less than 4 months. needless to say, i could no longer keep taking that. my doctor changed me to trintellix, and it has worked very well. it is the only antidepressant that i have been prescribed that has not caused me to gain any weight. also, it is fairly cheap if your insurance covers some and if your doctor gives you a coupon."