"i had been on zoloft (50mg/day) for depression for 8 years. following a major chronic health condition, a medical specialist was concerned the zoloft was no longer effective. increasing to 100md/day was disastrous - head spins, dry dry mouth, vertigo - so a psychiatrist recommended effexor. initial 75mg/day then 150mg/day after a fortnight. initially i was unable to orgasm but this lasted only about a month (same when i started zoloft). main concern is weird dreams most nights. the only thing i can tie this to is the effexor. have been researching online and it seems i&#039;m not the only one. what a relief to discover - i was becoming quite concerned (and irritated). but hey, i feel soooo much better that i can live with it. i&#039;m smiling again."