"i have been on it for 16 years when i just had my first child i was18, i have no menstruationl,  i have gained of course,  i feel upper stomach pains and was even being treated for ulcers and am endoscopy showed i didn&#039;t have ulcers, i have acne which does not seem to go, i have lost interest in sex etc... it is today that i have come to learn more about depo after reading comments here.  i did not know it&#039;s not supposed to be used for more than2 years. i had my shot on 9/12/17 . i will switch to something else.  thanks all for your comments."