"i have been taking 30 mg once daily for the last month. it&#039;s definitely doing something. i&#039;ve broken out everywhere and i mean everywhere. huge, gross, cystic and nodular pimple. but my dermatologist said that it has to get better before it gets worse. where my skin isn&#039;t being overran by grossness you can tell that it is clearing up and looking healthier. tomorrow i will start my new dosage of 40 mg twice daily(the first month you start with 30 a day and then after that my dermo said they figure it out with your body weight) side effects: pretty bad chapped lips, dry wrists and arms, also always in the bathroom cause i&#039;ve been drink between a gallon and half to two gallons of water a day."