"i have it all...anxiety, depression and insomnia.  sometimes i can be anxious in the morning, depressed in the afternoon. have tried wellbutrin/cymbalta combination, pristiq, viibryd, effexor, and every ssri.  i definitely felt an improvement with cymbalta/wellbutin and pristiq, but not 100% myself.  remeron has been a god send to me.  it works fast; dare i say i am in a good mood again after only three days. i was a bit tired in the morning, but i will gladly take some fatigue to rid of the anxiety and depression, and i hear this goes away in time.  as far as the weight gain, i have always been a good eater and go to the gym, so if my appetite increases (it hasn&#039;t as of yet) i will just have to monitor it. so far, it&#039;s been great."