"i have bipolar disorder/panic attacks/anxiety/major depression - needless to say there&#039;s a lot on my plate. however, for my depression aplenzin has been working very well. i don&#039;t get so frustrated over the extremely simple things like not finding a sock (as a personal example). overall i think aplenzin is good. aplenzin gives me energy and helps my personal outlook. i take 522mg a day. i&#039;m pleased with this medication, i do though take into consideration that i&#039;ve only been on it for about a week so i am on alert for any changes. aplenzin works great for my depression so far."