"i was given this medication by a dermatologist assistant, and started with the low dose of 50mg. i was a bit &quot;dried out&quot;, had to urinate more and was drinking more water. i didn&#039;t see much difference in my acne until she increased the dosage to 100mg but then i saw a major improvement. the draw back is that i am 44 years old, and my periods were getting heavier, a longer duration, and started every other week. i had some depression spells where i would cry over something very minor. i feel this medication is great for the acne sufferer who has had the same stubborn big deep blemishes for a long time, but for a hormonal person such as myself pushing menopause, it isn&#039;t ideal unfortunately. "