"i have horrible hormonal acne and bactrim has been the only systemic drug that has helped. problem is i took it for years, randomly when needed.  after years of usage, oddly i became allergic to it.  i broke out in large red spots that were extremely sensitive.  it&#039;s a serious allergy. i have permanent dark bruises all over my body and it has been years since i&#039;ve used it.  if you haven&#039;t tried bactrim.  try it. it will work for you."