"after months of sleepless nights, i finally went to the doc and was prescribed amitriptyline about 6 or 7 days ago. the doc said not to skip a dose - to take it every night. it takes about 2 weeks to get into your system enough to work properly. jury&#039;s still out, but it does not put me to sleep for several hours after taking it, and sometimes it doesn&#039;t work at all. i was wide awake at 5:30 a.m. morning before last. last night i was asleep within an hour of laying down and slept until 11 a.m. this morning. some days i feel groggy, and others i feel refreshed. my pain level has decreased drastically. have bad, arthritic knees. wondering if this drug helps relieve inflammation? i think it makes me calmer the day after. still hoping....."