"i had an unexpected medical issue and was initially prescribed buspirone to help deal with the ensuing depression. it took so long to kick in that all the other medicines i was taking made me suicidal. i talked to my doc who recommended a relatively new antidepressant called pristiq. from the moment i started taking it my life changed for the better, no more suicidal thoughts, my days returned to normal. i took it for six months until i felt i no longer needed it. i reduced my dosage as directed and weaned myself off it. there were a few brain zaps as the dosage decreased, but once i understood what was going on everything was fine. the only downside i can think of was a decreased sexual drive, but with a great partner we worked our way through it."