"i have been taking pristiq for about 3 weeks now, and i am extremely tired 24/7. now mind you i do have a busy schedule (full time job and classes 24 hours a wk). i do notice however that things don&#039;t bother me like they used to and my crying has eased up a bit. i have started having some nausea, hopefully the tiredness and nausea will diminish the longer i take pristiq."