"at first i was reluctant to take a pill even though i had been diagnosed with major depression.  my family talked me into taking this medication. i am on my third week of taking zoloft. the first week my doctor started me on 50mg.  the first few days i felt awful but stuck with the medication. i had not felt much relief in my depression and anxiety on 50mg so my psych doc put me on 100mg after two weeks.  i am on day 4 taking 100mg sertraline and have already started to notice a difference in my mood.  i am less anxious and worry much less at work.  i am also beginning to venture out of the house more than i used to.  the only side effects i&#039;ve had on sertraline are mild headache, diarrhea, and decrease in sexual performance."