"i have low back pain and down my right leg from osteoporosis, arthritis and degenerative disc disease. for two years i have cried most of the night in severe pain. this medicine takes about 45 minutes to kick in and lasts about 3 hours at 5mg. the problem (i think) is that my doctor will not raise the dose, which i understand but only allows me to take it every 12 hours. after about 3-4 hours i&#039;m in severe pain again and just watch the clock and cry. the label on the bottle says every 4 hrs as needed but will not refill if i take more than 2 a day. "