"i&#039;ve taken zoloft off and on for depression and ocd for the past 10 years and have experienced few side effects. i am now taking 100 mg and am fine continuing on it for the rest of my life, though perhaps i&#039;ll go down to 50 mg at some point. it&#039;s been a real life-saver for me; i am rarely down and still feel very much myself. also, it hasn&#039;t led to any weight gain. in all, am very satisfied."