"i stopped taking topamax for mood disorder due to side effects of tingling on fingers and legs. i was recently prescribed 75 mg effexor er for chronic depression the generic. i started on the jan16th noticed be loss of appetite first day, and 21jan16 weighed in at 228.2 from 234 @ 5&#039;6. my mood has also improved, now i have a bit more energy, and feel hopeful despite my situation not looking that way. i will be adding wellbutrin with my effexor. i hope the depression continues to get better and hoping to lose 70-80 lbs. as well. give it time if it isn&#039;t working try something until you find the pill(s) for you, different pills work for different people. we all deserve a better quality of life then we had before. good luck"