"i&#039;ve been on this for 10&#039;yrs now, obviously it works but at 100 mg dose, too much! i&#039;ve cut back to 50 mg and i&#039;m fine. on 100 mg i had a lot of weight gain, like 30 lbs. i&#039;ve lost a lot of weight now on 50 mg. i probably should go off of it but doc says if it works can stay on it. i worry no long term studies on this drug, but so far seems okay. my brother told me it can cause brain cells to die of w/long term use, he read it in l.e.f. magazine. don&#039;t know if true, but helps my depression &amp; anxiety so much that its worth staying on. be happy and healthy, find what works for you. good luck! "