"i&#039;ve found clonidine to be unparalleled at preventing anxiety of the restless and impatient type. i.e. the kind of anxiety that keeps me from sitting in one place. i take clonidine before any engagement where i must sit for a while, e.g., waiting rooms, court rooms and so on. places where some patience is in order. clonidine is the best for this. the only side effect is a very slight dry mouth, and that only happens sometimes."