"i&#039;m very treatment resistant bipolar type 2, typically severely depressed, with ocd and several other comorbid diagnoses, and antidepressants for me, if they work, will tend to poop out after only a few weeks to a few months. this was not the case for duloxetine. i started on 60 mg and it worked wonderfully for several months, the longest any antidepressant has worked for me. then, that summer, i became depressed again. after trials of other meds, i wound up back on duloxetine, this time at 90 mg, which worked for another 6 months. i begged for 120 mg but for some reason my psychiatrist refused to prescribe it, so i had to switch to something else. recently i wound up back on it for about a month or so at 120 mg, then at 80 mg."