"cymbalta works very well for me.  i was very reluctant to try it because of the concerns other users have brought up re: side effects and horrors of withdrawal symptoms and talk of &quot;brain zaps.&quot;  i started cymbalta after trials of wellbutrin, lexepro and celexa within the last two years.  i was desperate to relieve my depression. i began cymbalta in the spring of 2011.  one side effect i occasionally suffer is stomach upset/burning. tums relieves the symptoms as well as omeprazole. the other side effect i occasionally suffer from is the flu like symptoms (withdrawal symptoms) if i forget a dose or am late with a dose.  i found the best time to take cymbalta, for me, is at noon."