"i tried tretinoin 0.05% a year ago and i stopped as it didn&#039;t have any effect no side effects either. so i went back to the doctor a month ago and the doctor said it can take up to 6 months before i could see any results but it&#039;s worth doing.  so i used the same cream and again i didn&#039;t notice any results until 3 weeks which gave dramatic improvement. it hasn&#039;t dried out my skin. my advice is stick at this medicine for at least 6 months because it&#039;s worth it. take doxycycline antibiotics at early stages to help with negative side effects of acne getting worse in early stages."