"i have been on lolo estrin fe for about a year and a half now. this is my first bc pill. after taking it for the first time, i basically had what felt like severe pms for a week or so, accompanied by cramps, general moodiness, and spotting. after that, it seemed to even out and things got better. my main complaint is that i seem to be much moodier than i&#039;ve ever been in the past during my period - becoming depressed and i have almost no sex drive. i have had major breast tenderness in the first few months of taking it (feels like my boobs were getting bigger and just achy).  i&#039;ve gained a little weight (4lb) but nothing unusual. but, i also can&#039;t seem to lose it, either. (i bike everyday for at least an hour and am generally a healthy eater"