"i&#039;ve been on sertraline for almost a year now. on the 25mg i didn&#039;t notice any kind of difference. i was suffering from major depression, self-harm, and suicidal thoughts. my dr bumped me up to a 50mg dose &amp; have stayed here for about 8 months now. my girlfriend calls it my &quot;happy pills&quot; because when i forget to take a dose or two, everyone can tell."