"in &#039;97 i was suffering from depression so badly, i entered a clinical trial for antidepressants. specifically, effexor xr. i had never been on antidepressants before and i was astounded at how much better i felt. then in &#039;06, after the 2nd work supervisor said i had &quot;no sense of urgency&quot; i decided to switch medicines. my doctor said so many patients became apathetic after long term use. getting off was a nightmare! but now i&#039;m on lexapro. it hasn&#039;t lifted me up like i&#039;d like either, but maybe that&#039;s the way it&#039;s going to be. i experienced weight gain with effexor and actually lost weight since i&#039;ve been on lexapro, which has been for about 2 years now. would like to get off all medicines period."