"i was on ortho tri-cylcen lo for a few years. i decided to change it up and try yaz and this made me insane. i had horrible mood swings, i was depressed, i didn&#039;t have any interest in my job or friends, and i just wanted to die. my boyfriend made me switch back to ortho tri-cyclen lo and i was back to normal. it was an awful experience, and its disturbing how something can change you so drastically. i know other people who are perfectly fine on yaz, but it did not agree with me at all. i think it was just too much hormones for me. every body is different."