"i have been on cymbalta for about 4 years.  worst side effect is sweating, which can be annoying.  also, if i lay down during the day, i can go to sleep at just about any time; so i don&#039;t lay down.  much less sexual side effects than other anti-depressants i was on (several of them).  since there is no generic, it is a bit expensive, but i feel so much better than i did before, it is worth it!"