"i first got on depo almost 9 yrs ago. i was on it for 2yrs. almost immediately after the first shot up until the month after i stopped i had no period. but i also had gained 45lbs after 2yrs! after stopping, my periods immediately returned to normal. i had been off of depo for 5yrs and had regular, unprotected sex with my boyfriend of 4yrs now and did not finally conceive until after 2 1/2yrs of actively trying. finally conceived, thankfully! decided to get depo once again and this time, i have bled/spotted off and on since i have birth randomly sometimes 2weeks at a time and it&#039;s been 8months postpartum. decided to stop injections and try different route. also since it took so long to get preg. before doc advised to stop sooner next time"