"i suffer from severe post traumatic stress disorder, depression, panic disorder . the comment above me was almost like a mirror image! i was so relieved to see that another person has been on every anti-depressant out there and none had really worked... for me however, all the anti-depressants i have been on in the past have actually caused an opposite effect than what they are meant to do. i would become even more depressed and even suicidal. i have systemic lupus, (among many other serious health issues) and in my case, the lupus is very severe. it is pain, every waking moment. the fetzima 40mg has helped a bit with that, it hasn&#039;t made me more depressed and i think i may even be feeling a bit more positive. so, all in all, i think it may be working : )"