"i have been on pristiq for almost 2 weeks.  i have been through the medicine mill in the past 10 yrs, started on zoloft and loved it but hit the 5 yr mark and it stopped working. then i went to paxil which didn&#039;t work so hot. then there was celexa, cymbalta, lexapro, remeron, effexor, and even prozac so i feel like i have been there done that.  i also have to take trazodone to sleep at night.  i suffer from severe depression and anxiety and on top of that i have insomnia and even panic attacks.  for a long time i have just felt like i was going crazy and nothing was going to make me feel better. so far pristiq has made a big difference. hope it gets even better in the weeks to come!"