"i was prescribed 50mg of spiro a day with topical tretinoin gel (19 year old female here). i started noticing improvement in my acne after i introduced that topical gel into the equation (so i imagine that the topical caused most of the improvement). two weeks after starting spiro, i started noticing hair all over the sink and a ton in the shower drain. i experienced tightening of the throat on and off after a week (a subtle annoyance, not super severe) and didn&#039;t attribute it to the spiro, but eventually i realized my voice sounded very deep, unacceptable as i&#039;m a singer. i had no idea this was a side effect until i looked up spiro side effects and it explained everything. i stopped taking it after this and won&#039;t go back at this dosage."