"i always had perfect skin as a teen until i hit about 24 then it went down hill. nothing worked, most topical treatments made it worse, proactive made it worse than worse, murade and others as well. nothing worked. sooo i researched spiro and found my symptoms and timing etc. fit others my age, 37 that dealt with it late in life. i asked my dermatologist about it and she gave it to me along with a topical gel. i have only been on it about 1 week but i can see the difference already. my skin is evening out, the large pores seem smaller and the hard bumps are nearly gone. i have not had one break out and even my back is much clearer. it is amazing. i don&#039;t pee too much more but i do find i get out of breath easily. seems to be working on my skin"