"i was on zoloft for about 5 years. before that i was on effexor and paxil which i did not tolerate well due to the half life. zoloft was good but after several years i developed side effects. tremor, jaw clenching, weight gain, sexual dysfunction...i weaned myself off of all meds which was really hard. it&#039;s been nearly a year and i&#039;m ready to go back on something. i&#039;ve tried natural therapies for sadd, pmdd, depression, anxiety and it&#039;s not working."