"aplenzin unfortunately did not work for me.  i have panic disorder which then sent me into a horrible state of depression.  my psychiatrist first prescribed me wellbutrin sr which i was taking twice a day.  after about 3 months i started having moments where i was actually happy to be alive.  at my next appointment, my psychiatrist asked if i would be intereseted in trying aplenzin because it only needs to be taken once a day.  i started off on 348 mg for three months.  this was not working so he switched me to 522 mg.  two months later it is still not working.  i spoke to my pharmacist who told me that i have been patient enough and if it is going to work  it would have done so by now."