"warning, caution! if you are doing remicade treatments for crohn&#039;s disease that involve iv phenergan. the day after my 56th treatment i took my 2nd dose of pristiq and within 30 minutes almost passed out, became very disoriented, drifted in and out of reality. i have done 56 of these treatments and yes the after effects of phenergan and remicade tend to make you tired for a couple of days but not disoriented. i have waited a couple of days to let the premeds from the treatment get out of my system more and will try pristiq again bravely! i can note that the first dose i took the day before my treatment had no effects like this so it must have had an interaction with something (either the remicade or phenergan."