"i want to i really say people should wait at least 3 months before they rate deplin or any psychiatric medicine, unless you have some major horrible reaction. deplin gave me a kick start the first week i took it for some reason but then the effects disappeared.  i talked to the p-doc and he said it takes something like 6 weeks to build up in your system. well after about 6 weeks or so i started to notice the effects. it gave my wellbutrin a huge boost and my energy level rose through the roof. people rating a medicine after 2 days is just ridiculous and annoying. even the ssri&#039;s take a couple weeks to work. stop it people."