"i have been on orsythia for about a year (and on various pills over the last 10 years) and it was fine at first. however in the last 4-6 months have noticed a huge change. weight that i just can&#039;t seem to shed, hormonal acne on my jawline and neck, no sex drive, and really awful moodiness and depression. everything else in my life is peachy so i knew it was my hormones due to this pill. "