"my doctor prescribed pristiq 6 months ago for major depressive disorder with anxiety. i have been on several different antidepressants but this one took the longest to work. it took 6 weeks. i was nauseated for the first month. it finally started working and i felt less depressed but lately i am very moody and irritable. sometimes all i want to do is stay in bed and at other times i&#039;m up all night (like now - it&#039;s 3:55am). can&#039;t take this any more. good luck."