"i have suffered from major treatment-resistant depression for 32 years.  i&#039;ve tried so many medications along with polypharmacy for this, and almost nothing helps.  the only antidepressants that are of any use are citalopram, buproprion, and abilify.  even this combination doesn&#039;t always work--usually the citalopram stops working after a number of months, and i have to switch it out for sertraline.

a few years ago, my psychiatrist tried adding 20 mg of methylphenidate twice a day.  what a difference!  i am now able to get out of bed, work, focus, smile, and have something that approximates a normal life.

the only problem with this, is that i am now completely dependent on the methylphenidate in order to function."