"i have chronic idiopathic pancreatitis, allodynia, gastroparesis &amp; tarsal tunnel syndrome. i was also, just recently tested for lupus. i was taking norco (hydrocodone/acetaminophen) for a year until my new doc realized it was making my gi issues worse. we switched to nucynta er 150mg/bid &amp; nucynta ir 75mg for breakthrough. while they worked the first few months, i seem to be building a tolerance. i feel like the er takes the edge off when my pain is between 4-5. but, both ir &amp; er cause excessive sweating. i mean, there are days i have to change clothes multiple times daily. it&#039;s embarrassing. but, the nucynta does not have any of the gi side effects (constipation namely) that other narcotics do."