"i&#039;ve been on kadian for 8 months (car accident 3 years ago, suffering from extensive postural and disc and recently diagnosed ptvs symptoms since). i&#039;m 22 and started feeling able to live my life again after taking kadian (10mg 2 x day) and it seemed to make my mood better. it no longer works at current dose and doctor won&#039;t move up a dose, and doesn&#039;t believe in short-acting medicines. first 6 months it really did wonders and gave me a lot of my life back. constipation is brutal with this medicine - i take miralax daily with some relief. withdrawals are horrific."