"my uncle(who is a doctor),suggested epiduo, and take a medicine called minocycline/akamine. i take the mino twice everyday and the production of acne reduced in the first few weeks.at the same time, i clean my face every night with a gentle cleanser and put moisturiser. afterwards,i put the epiduo on the infected area. people have been saying that, it hurts/burns, but for me it was only the first night. i was itching badly, i couldn&#039;t sleep. so i put a lot of moisturiser on my face. afterwards, it didn&#039;t hurt/burn ever.  i don&#039;t put epiduo on my face everyday but when an area of my face is only infected. i&#039;ve been using it for 5 months and its heaven. no acne at all. epiduo only helps clear the acne on your face not clear it, the medicine does"