"i went on epiduo at 20 years old, having acne since i was 17. my acne was moderate and occasionally moderately severe, my skin type normal/slightly sensitive. after day nr 2 of epiduo, i got an allergic reaction. my eyes swelled up, my whole face was rough and red and at one point i even had slight swelling in my throat. i went to the emergency room and was put under an iv drip of antihistamines or something. call me crazy, but i didn&#039;t give up. after my face healed (i.e. was no longer dry as the desert and red), i started re-applying small amount every other day. eventually working my way up to pea sized amounts per target area per night. it almost cleared my acne up! i still have breakouts, but nothing what i used to three years ago."