"so we are still learning about methylfolate and its effects in depression as it&#039;s still pretty new (megavitamin) and we&#039;re still learning about the role genetics play in the methylation cycle. i noticed a boost after a week on 15mg then it disappeared. i kept taking even though it wasn&#039;t really working anymore. then after about six weeks i got a huge boost and as i was also on wellbutrin at the time, it was actually way too much serotonin in my system. i think some people need doses much lower than the prescription strength and it can take a while for the full effect to kick in. it can take a little while to get back to a healthy level but it can definitely help boost whatever else you&#039;re on. look out for hypomania if you&#039;re bipolar."