"i have intermittent problems with mild depression and moderate anxiety usually due to financial stress. i have been taking 50 mg for a week and i have noticed that my anxiety has been substantially reduced. and i notice no negative side effects with pristiq. i only notice that i am more energetic and awake all day long. i have no sleepiness during the day or trouble sleeping (problems i&#039;ve had on other drugs). really good medicine so far. i don&#039;t give it a 10 only because i have only been taking it for a week. i&#039;m curious to see if the effects last longer term."