"i have been on over 15 different antidepressants across every category. i have taken monoamine oxidase inhibitors (ensam), tricyclic antidepressants, ssris (several - effexor, pristiq, etc.) and nothing worked. i&#039;m taking welbutrin 150 mg once a day (along with the effexor xr still at 300mg) and it is incredible. i feel amazing. unfortunately, after 3 weeks i developed hives all over my body that were itchy. while the itchiness went away after 3 days and the hives only come out at night now, my blood work shows i&#039;m having a bad reaction to it. i also lost 14 lbs in 4 weeks (a good thing). i do feel extremely anxious and agitated at times and can&#039;t stop wiggling my foot, for example. combined with the effexor (which causes too much sleep), my sleep is at the right length now."