"i&#039;ve been taking pristiq for about 2 weeks now.  i feel a lot better.  i have had increased energy, and a great mood during the day.  my doctor told me i would start to feel the affects in about a week or so, but i felt them immediately.  i have also lost 13 lbs.  i have had a few side effects though.  namely, muscle cramps, and diarrhea, but i believe these will, pass.  i am going to stick it out.  i have also been taking the medicine in the mornings to avoid problems sleeping."