"i took pristiq for years and it was wonderful.  unfortunately my insurance changed and i wound up on effexor, which caused me horrific night sweats.  when i saw pristiq had a generic, i was thrilled!  now that i&#039;m on it, i realize it&#039;s not anywhere close to the brand name.  i feel terrible on it.  i have headaches, jaw pain, i have heartburn, and i&#039;ve even noticed some heart palpitations.  i&#039;m really disappointed in the generic, but i don&#039;t want to go back to effexor and deal with the night sweats, so i&#039;m kind of at a loss for what to do.  i&#039;m hoping if i give the generic pristiq more time, my system will adjust.  i feel for the rest of you are having issues, because it&#039;s not fun."