"i&#039;ve been on lo lo estrin fe for about 2-3 years.  i was having severe mood swings whenever i was on the white or brown pills, anger follow by depression.  when i told my doctor, she said i could take the blue pills continuously and now i have no periods, no cramps, and no mood swings.  last week i missed a pill and took it 12 hours late (in the morning), a few days later i was severely depressed and had breast tenderness that lasted 2-3 days.  usually it&#039;s perfect, but a few hours with out it can cause days of depression, so i recommend others use it with caution and i would not recommend for anyone that cannot take the pill at exactly the same time daily.  also you can run into insurance coverage issues by skipping 4 pills a pack."