"everyone&#039;s experience with a drug will be different. in my case, being a 6ft, 170 pound male with depression on 50mg of zoloft , i had a good experience. it wont be the same for everyone but you have to hang in there until you find the right medication. i tried lexapro previously 10mg and it was too intense for me. zoloft is a little bit softer and less intense (for me anyway) . the first two weeks sucked , i had increased anxiety and it was hard to sleep but it was worth it. i was going through withdrawal syndrome from lexapro (i stopped taking it) and the zoloft cured me in about 3 days. it has helped my depression alot, and a little bit of my anxiety. i want to stay on 50mg as long as possible and i am hoping this will last.  i"