"so far so good. this is the only medicine i have been on for depression but have had depression and anxiety for years. i feel it has really helped. i was also given xanax for anxiety but feel i don&#039;t even have to really take it because pristiq is helping with that too. i lost a lot of weight but finally have an appetite again after not having one because of weeks of depression. i recommend anyone try this. it definitely made me feel better, more energy and a happier state of being. only side effect so far is a little trouble sleeping, clenched jaw sometimes and nausea when you first start but that went away once i ate something."