"i went off of depo 2 years and 7 months ago. i can not have a period on my own, so i no longer ovulated. we have been seeing a fertility doctor for 7 months. i can only have a period and ovulate with medication, but we have still had no luck. the only thing they can find wrong with me is the shot. i&#039;m so upset i may never be able to have another child. do not take this if you ever want to have children. that&#039;s not including the side effects during: severe weight gain, mood swings"