"i started nucynta the first time and was on a low dose of 25mg of zoloft. had been taking hydrocodone 10mg for several years. the reason for zoloft was for minor depression that the hydrocodone causes. the first two pills i had of nucynta caused insomnia and weird dreams and a bit of anxiety. also, i had shivering and so hot i felt i was burning up. even though my rheumatologist/pain specialist suggested i give it 5 days, i did not. well, a couple of weeks later i am trying it again. so far, so good. my pain level is better but not yet all gone. i did have to take a hydrocodone early in the morning as i started having withdrawal symptoms from not taking it. i was told i would not. glad for nucynta. i have neuropathy, fibromyalgia, 2 kinds of arthritis."