"in the last 6 years i&#039;ve been on effexor and pristiq (synthetic effexor and i had horrible withdrawal from them), zoloft, wellbutrin, lexapro, and mirtazapine. none seemed to work for long and most didn&#039;t seem to help at all and i&#039;ve wondered if i am resistant to the meds. in addition, my anxiety has been awful. finding an anti-anxiety drug has been tricky because i&#039;m in recovery (used to self-medicate my depression and anxiety) and i need to be extra careful about taking certain medications since i have the tendency to abuse them. it&#039;s too early to tell if brintellix will work for me but the genetic testing shows it&#039;s a good match. the nausea is bad, but i&#039;m used to taking meds on an empty stomach so will start taking it with food."