"i&#039;ve been suffering from depression and anxiety for 8 years with little relief from other antidepressants and combinations (zoloft, lexapro, lexapro &amp; lithium, imipramine, desipramine) and cognitive therapy. i became so sick of switching medications that i just pretended everything was okay until it was too much to bear. i&#039;ve been on budeprion xl for about a month now, increased from 150mg to 300mg. other than a periodic rapid heart beat, some brief sleeping interruptions, and a tad bit of irritability, i can honestly say i&#039;m starting to feel a bit better. i&#039;ve got more energy than i&#039;ve had in a long time as well. i would just recommend that if you&#039;re a heavy caffeine consumer, maybe cut back a bit to reduce some of the symptoms."