"i have been on brintellix for 9 months, and it has helped my depression tremendously, although the nausea side effect has never gone away.  i have had to take a 4mg zofran one to two times a day.  at my annual physical, my gp told me to get off the zofran because there are no studies for long term use of zofran, and there is a serotonin receptor inhibitor in it.  i take 20mg of brintellix.  i decide to give it a try, and i can&#039;t stop vomiting.  it is so bad that i took the zofran to control it.  today i took a half tablet, and i feel like i&#039;m going to vomit at any time.  i took today&#039;s dose with food.  has anyone else had this?"