"we are disappointed.  my 14 year old son has taken 40 mg 1x/day for 18 days and his skin is worse than ever.  he seems more moody than normal and his lips are super chapped (i feel like the chapped-lip police with my chapstick in hand).  we really hoped for results of any kind with his cystic acne.  we are going to try a higher dose after he gets the blood test in a week or so. he is discouraged. the cost of the higher dosage is almost prohibitive.  our insurance doesn&#039;t cover meds because we have a high deductible but we feel that clearing up his acne is important for his self esteem.  it seems criminal to charge so much for meds."