"seroquel is the only medication that has really worked for me. i have major depression and possible bipolar disorder and it&rsquo;s helped lessen my degree of depression and help me get on a more steady path. psychotic symptoms are under control. i thought i had treatment resistant depression for a long time until i tried this. the only problem is the sedation. i&rsquo;m on xr and i don&rsquo;t have the sedation as bad."