"i have suffered with some depression but mostly anxiety for the past 15 years. i have taken celexa and then lexapro off and on (mainly on) for most of those years. while the lexapro helps some, i still always had difficulty with my energy levels and with coping during really stressful situations. i was recently tested for mthfr gene mutation, and was found to have the 1298c mutation, which can affect my brain&#039;s ability to utilize folate in order to make needed serotonin, dopamine, and norepinephrine. my doctor prescribed deplin (l-methylfolate), and even though i had read many good reviews, i was still hesitant. i have to say it has been a miracle for me. it&#039;s like this dark cloud has been lifted, and my anxiety has completely disappeared."