"i use zoloft for my depressive episodes due to bipolar disorder. i have unsuccessfully tried about fifteen other anti depressants in the past. zoloft works wonderfully! with zoloft, it doesn&#039;t take long for my depressive symptoms to fade. the only side effect that i experience is the complete loss of my sex drive. it is very common with ssris. fortunately, i talked to my doctor about it and he prescribed periactin to take with it. periactin is very effective at addressing the issue."