"i was put on this medication one month after it&#039;s fda approval for major depressive disorder. i was told it would probably take up to 3 weeks for a noticeable difference in my mood and behavior, but i noticed a difference on day 2. i felt like i was able to have emotions and feelings again. i was not as irritable or angry, and i felt like i had more energy and confidence. when i stepped up the doses i had the gi side effects, but those have  been resolved when my body adapted. i still get restless legs occasionally at night, and when i forget to take my medicine i get really itchy, irritable, and hazy. but the good outweighs the bad. i feel great! try it!"