"i have been taking methadone hcl 10 mg tablets for 10 years for chronic pain. i love this medication greatly and yes it&#039;s a lifesaver for sure. i had been on everything from ultram to oxy 80. i can tell you that this medication blows them all away. i started out on 3 a day for 8 years and in the last 2 years i have been on 4 a day. my pain is managed to about 96%. it seems to take a really long time for immunity to set in. this is the best pain medicine on the market. "