"i&#039;ve been depressed for about 14 years. i was on wellbutrin along with cymbalta. i was doing weli, but sleeping a lot. my np suggested trintellix. she weaned me off of cymbalta and started me on 5 mg of trintellix for a week, then upped to 10 for 2 weeks, then started on 20mg. i immediately started having terrible mood swings, with anger and irritability. i have since gone back to 10 mg, however,  i cry at the drop of a hat, i have no energy, i have muscle aches and i have a terrible neck ache. my anxiety level has been thru the roof and i have no appetite. i believe this medication has also given me diarrhea. this medication is horrible."