"i have been on brintellix for nearly six weeks.  i experienced severe nausea for the first 10 days but thankfully it subsided after that time.  the medicine has mellowed me out but i still feel very zoned out, tired and listless.  i don&#039;t have a &quot;joy&quot; for life with this medicine that i experienced on another antidepressant in the past.   my major concern is an increase in blood pressure.  i am an extremely healthy 35 year old female whose blood pressure has always been 110/70.  since starting this medication, my blood pressure has gone from 110/70 to 120/82, then 139 over 74 and now 149 over 80.  nothing has changed in the past six weeks other than the addition of the medicine.  i&#039;m hoping to find something that is going to work soon."