"i am reading other users comments because today is the day i have my first mirena taken out and intending to have a replacement put in immediately. (hoping it won&#039;t be as painful as the first time in aug 2004 - although this time i might take painkillers before, as some others have reported doing). of interest to me was the report by some that symptoms started to creep in as the end of the 5 years approached.  i have had significant weight gain over the last year or so but put it down to a more sedentary job, eating out and more regularly drinking wine. i also suffer with clinical depression. now wondering if both are related to the looming expiry date?"