"i just started today and wasn&#039;t expecting to see any difference as most antidepressant take weeks to see any difference. today about 2 hrs after taking i felt so tired. being at work didn&#039;t help. i have read many of the other comments and am hoping it&#039;s a miracle drug like a lot have said. i take seroquel for sleeping that i think will help as a lot of others say pristiq interferes with sleeping. hopefully i will be back to write again and hopefully there will only be positive results to write about."