"i&#039;m a 44 yr. old female and i&#039;ve taken 50mg of zoloft for 3 weeks now. i&#039;m grateful for it. it&#039;s helped depression, ocd, ptsd, anxiety, panic attacks, terrible thoughts, mood swings, and my urge to drink alcohol. the biggest relief of all is that it&#039;s helped my pmdd! i felt a weird feeling in my legs, at night, for a bit, but that seems to have gone away a few nights ago. i have dry mouth and chew gum to help. i feel lifted, happier, calmer, make better choices and feel clearer in my thought process and more alert and aware. pre-menopause/pmdd, can cause you to feel like your going crazy...you&#039;re not, it is hormonal. ask your doctor about this! wish i had 4 yrs ago, it is working for me and maybe it can help others. good luck!"