"my experience on spiro has been somewhat beneficial. i&#039;m a 23 year old female who has pcos and has been on 100mgs for 3 months. my acne hasn&#039;t cleared up 100%, but my cystic acne has decreased at least 80% if not more. i still get breakouts though. my side effects are: extreme dizziness, needing to pee a lot, my mouth gets super dry, my body is dry and requires more moisturizer on my hands, legs and feet. the dizziness is absolute worst though. i have to take it at a certain time or else i can&#039;t drive during the day, or i&#039;m up peeing all night. i&#039;m hoping with more time things will clear up more. i haven&#039;t had any issues with weight gain. i&#039;ve actually lost weight and have noticed a decrease in hair production in unwanted areas."