"i had been on effexor for five years and had noticed a decrease in helping me with my depression so my dr switched me over to cymbalta ... i did not get harsh side effects aside from a little jitters at the beginning but it soon settled. i must say i have been on it three months and i have been waiting for my anxiety to subside ... cymbalta no help there at all. pain i have ankelosing spondolosis ... curved spine and pinched nerves (severe sciatica ) no help there either. maybe my case is just a little more than 60 mg a day can handle ... but honestly i&#039;m ready to go back to effexor, vicodin and alprazolam. at least they worked. if anyone has advice please drop a line."