"effexor xl has worked very well for me in combating my depression. i have been very diligent in taking the medicine properly and on schedule every day at near the same time. this past weekend due to an oops at the doctor&#039;s office a refill was not called in properly to the pharmacy before i went out of town for the weekend and i left town without any effexor. needless to say i experienced effexor withdrawal symptoms. heed my warning! it&#039;s not a good idea to miss a dose and you definitely do not want to miss any doses. it was awful. don&#039;t let the script run out."