"i&#039;m on my 2nd pack of sprintec and the biggest side effect i have gotten is bad acne around my jaw line and chin, cystic acne.  i&#039;ve had to use proactive so it wouldn&#039;t get worse. more headaches and body pain. my period was a little heavier and more painful then when i was on minastrin 24. my period came 2 days earlier then before. i&#039;m not sure about weight gain yet but minastrin was terrible, i gained about 15 pounds."