"i was experiencing headaches, like by brain was wound tight w a rubberband, didn&#039;t want to get our of bed, no reason to... my dr prescribed pristiq.  it has been a life changer... head feels much better, depression is gone, life is happy again.... side effects are flu like symptoms, crashing, if i miss a dose.   i take a .25 mg.  i ha e tried to come off before and experienced severe headaches and flue like symptoms, and severe body aches.. so i got back on...  it is expensive but i buy a 90 day generic  supply thru canadian pharmacy for 120.00.  ins doesnt pay due to out of the country but it is still less than what i wld have to pay in the us.."