"i have been on cymbalta for a year. has helped with depression and overall my moods have been better. it doesn&#039;t take much to make me sad, angry, or to cry though.  i suffer from constipation, dry mouth, decreased libido, very hard to get orgasms, nausea, forgetfulness and a few other minor side effects. wish they (most antidepressants) weren&#039;t so hard to go off of. i seem to go deeper into depression with any attempts to go off the medicines."