"this is my 2nd bout of depression. i am in early 60&#039;s and had my first bout about 10 years ago. paxil has been the most effective anti-depressant for me. major live with side effect is sexual - great erections but hard to ejaculate. otherwise paxil does excellent job of controlling my depression. each episode for me last about 6 months of treatment. don&#039;t forget to taper off according to doctors advice."