"i don&#039;t know if it&#039;s me or what but i was given demerol (along with vistaril and vicodin) after my ankle surgery and it hasn&#039;t helped at all. i was admitted to the hospital twice where i received dilaudid. that did the trick. i had a screw removed from my ankle, which had shattered and the doctor drilled through my fibula bone. after i was released, i was given vicodin to be taken one hour after my demerol and vistaril. that seemed to work. i was surprised that the demerol needed a &quot;kick&quot; so to speak. i would definitely ask my doctor for something more again if i ever had to go back on it."