"remeron helped very much initially. after trying a host of other depression meds, this one seemed to work and had minimal side effects after the first week. however, at a low dose it stopped doing the job and have had to go up twice to the max dose of 45 mg. i no longer sleep well, and have had huge weight gain and ended up with diabetes. i plan to gradually wean myself off and treat the depression with natural means--exercise, diet, supplements."