"i&#039;ve been on 50 mg pristiq for 2 weeks now. as a 39 year old male with anger/depression issues, i&#039;ve already seen a change in my behavior. i stay pretty mellow and let the small stuff roll (the things that used to make me really angry).  it&#039;s just starting to kick in so i still get angry but not near as much.  i&#039;ve also lost 8 pounds in less than 2 weeks. side effects have been mild headaches, loss of appetite, and the weight loss. i experienced night sweats and weird dreams only once."