"i have been on and off cymbalta for about 3 years. just today after visiting with my doctor and with my husbands honest feedback (he was there with me), i realized that i have to go back on it. so i&#039;m going off wellbutrin, which had worked great in the past. cymbalta really is the best anti-depressent that i have tried, and i have tried a lot.  the only reasons i ever went off it in the past was the bloated feeling i felt and weight gain.  so i am committing to eating better (watch calorie intake and get off the carbs) and excercising.  going to go buy a treadmill tomorrow. keeping my fingers crossed that i&#039;m able to stay on it for good this time."