"i take 60 mg of cymbalta for depression for the last 5 years and i&#039;ve felt a noticeable difference in my mood (depression lifted). i used to cry all the time for any little thing, and now my emotions are in check, no more cry baby! there are a few side effects, including out-of-nowhere jerking. it doesn&#039;t happen much, but when it does, it&#039;s weird! this is a medicine you cannot miss. i have inadvertently missed a dose and was back to the weepies, to the sadness. before i tried cymbalta, i had tried many, many other antidepressants and they never had any effect on my depression. then there was cymbalta. thank goodness for this medicine. i can&#039;t imagine my life without it. what a blessing."