"i was put on sertraline six years ago after my previous ssri, luvox, became ineffective.  i have found it effective at controlling my depression and anxiety, but there have been some major drawbacks.  primarily, i find myself unable to achieve orgasm during intercourse.  also, earlier this summer, i tried reducing my dosage from 150 mg to 100 mg - and i got a taste of ssri withdrawal syndrome, which really, really, really sucks - a veritable hell on earth.  i am currently looking into changing to a better tolerated drug."