"tranxene-sd (clorazepate-single dose) has helped immensely for my worry, anxiety, and major panic disorder! i take 22.5mg in the morning (2x 11.25 tablets) and klonopin (clonazepam) for my major panic disorder. the tranxene-sd helps keep the all day anxiety and worry from erupting into a panic attack to where i have to take the klonopin. it keeps me calm until i feel the need i have to take the klonopin. it&#039;s been around since 1972, and it works great. i recommend it for all day anxiety!"