"i have neuropathy in my feet and slightly in my hands. amitryptiline made my pain livable - still bad, but i could function. when i began taking cymbalta along with the amitryptline, almost immediately the pain subsided and practically disappeared!  i no long take the amitryptiline and cymbalta keeps the pain to a low ebb, allowing me to sleep and join in activities i had long given up.  doesn&#039;t do a thing for my &quot;attitude&quot;, but being relatively pain free does make me happy."