"i started up on 250mg and ended up at 1500mg.  i noticed very subtle effects if any.  hard to remember, i went through a lot and was on seroquel also at the time.  seemed to have a slight calming effect.  however after time it raised my liver enzymes and lowered my platelet count (which is a potential side effect)  so i went off of it.  i don&#039;t have many hypomanic episodes and never a manic episode so i don&#039;t know why my dose got that high.  didn&#039;t notice anything significant.  gained 20 lbs, made me sick and tired.  wasn&#039;t for me."