"after being on 80 mg of oxycontin 3 times a day i wasn&#039;t getting the pain relief. i went thru breakthroughs and my insurance would only cover generic oxy. saw a new pain doc and the nurse practitioner switched me to opana, only 30 mg twice a day. my breakthrough meds stay locked up unless i&#039;m doing something special. i always take opana with food (instructions say take on an empty stomach) as i found taking taking it with food makes it last longer. due to insurance i had to switch tot 15 mg, 2 tabs, twice a day. i found this give me some flexibility. if i&#039;m having a tough day i may take one around 5 pm and then only one at bedtime. medicare sucks though. i hit the gap about 6 months ago and found out i have to pay 4,800+ til it&#039;s done."