"i am on day 4 taking the medication. the only side effect i had was on day 1. the best way to describe it is that fuzzy a little sick to your stomach feeling you have when you step off a roller coaster. it only lasted the first day and was very tolerable. if you eat a tiny protein snack every 3 hours i think it helps or in my case prevents the nausea. so i&#039;m on day 4 and i&#039;m down 3 and a half pounds. i am struggling with weight gain due to menopause and my doctor thought contrave could be the help i need. i am also doing leslie sansone&#039;s miracle miles in home walking program. i am so hopeful that this works!! i will update in a few weeks."