"i have severe depression and general anxiety disorder.  i take 100mg/day of zoloft, and that pretty well takes care of my depression, and most of my panic attacks.  occasionally, i&#039;ll take 0.25mg for a panic attack, but i&#039;m cautious because sometimes the downside of coming off a panic attack sends me into a fit of depression.  i highly recommend both zoloft and xanax, i just want to put the word out there to use good judgement when treating a panic attack when you have depression as well."