"i started taking cymbalta after my doctor prescribed 2 other medicines over the space of 8 months, they made me feel worse not better. i was so ill i was hospitalised at one stage.  it took cymbalta quite a while-  about 2 months, to kick in noticably, however my depression was severe. the nausea was awful the first two weeks and dizziness lasted about a week with me. i am pretty sensitive to medications however. i have been on cymbalta for almost two years- at a high dose (90mgs). i do find i am hot and sweaty (at times), i need a lot of sleep and have put on weight, (though hrt could have caused this). however these side-effects are a small price to pay to live a normal life and be free."