"i was on the depo shot for about 3 yrs and went off it (only because it is recommended to take breaks from it) and went on yaz. i am aware that each bc affects everyone differently, i had a horrible experience. breakthrough bleeding, severe mood swings, headaches, and unpredictable periods. i got off it after 3 months and am about to try sprintec...here&#039;s hoping this works out better!"