"female, 43, 270.  after reading many reviews on this site i was very nervous about starting contrave.  i have been battling my weight for as long as i can remember.  recently i hit my highest point when i went on a medication for depression and anxiety.  i started the week of april 17 with a low carb diet as well.  1 week later i am down 9 pounds!!  i haven&#039;t really had any of the side effects that some people talk about.  i did have a very bad migraine one day (never get), but other than that nothing i can&#039;t deal with.  at this point, i am willing to try anything.  today, i start the 1 pill morning, 1 pill evening regimen.  i am hoping with the increased dosage, i will still feel ok.  i&#039;m praying that this will help."