"made depression worst ,was not effective even at 150 mg. i got an understanding of why people become alcoholics or drug abusers on effexor/venlafaxine. i would lay in bed all day waiting for life to pass by. i never had feelings of despair so severe. if i mised a dose or waited for an hour later to take effexor i had an intense &quot;rush&quot;. i would pace around like on cocaine or speed. you cannot stop taking this medication. i am still trying to get off it!  when i reduced my dose i had a drunk effect with nausea i just felt so awful. i consider this to be a drug that shoudnt be prescribed. celexa and zoloft &quot;robot drug&quot;worked well on me for anxiety and depression but i do not recommend this medication.  going back to elavil"