"i&#039;ve been on pristiq for about 6 months now, taking 50mg for about 6 weeks then bumping up to 100mg after that. i have noticed a huge change in mood. i don&#039;t fixate on little things and let them bother me for the whole day like they used too. i feel much more confident now and i am actually smiling lately. some side effects i have noticed are the occasional headache (i find if i take it the same time each morning i don&#039;t get a headache), drymouth, and if i miss a dose i get absolutely wild dreams and my anxiety comes creeping back in. also, i notice it makes me ramble on and on when i talk sometimes which can be a little embarrassing especially in work situations. overall though, the benefits significantly outweigh the side effects!!"