"like any pain pill, it will vary greatly on side effects and effectiveness with each patient. for me, i have been on 10/325 for 2 years for chronic pain from an injury. before that i had been prescribed hydrocodone and the side effects from that for me were alot like what i&#039;ve seen people here say about hydrocodone. i got a tolerance very quickly and would have to take more, i was very agitated, extremely exhausted, and even with all of that i would still be unable to be productive due to pain. i&#039;ve tried some other things before this also, but nothing was helping. i still have pain, and yes, some days nothing seems to ease it, on those really bad days, but i am really happy with this medicine still being effective 2 yrs later."