"i was 1st prescribed zoloft, which for me was absolutely perfect until none of my clothes fit about 3 months into it.  i gained 25 lbs and the weight gain brought new depression and anxiety.  i was put on wellbutrin which was a &quot;nice&quot; drug if your depression isn&#039;t too severe and i lost weight on the it, but it couldn&#039;t hold a candle to my problems.  then, i tried pristiq (and i also use valium and ambien for any additional anxiety).  it&#039;s a happy medium between the 2 medicines.  you won&#039;t have the side effects of zoloft (weight gain, loss of sexual interest), but you&#039;ll have a stronger backing against the physical and mental toll of depression and anxiety.  "