"i have taken seroquel xr for two years. i take 800mg at night for bipolar. at first it seemed like i would never come out of the haze but it wore off over a weeks time. honestly, really i have had no major bipolar problems since i have taken seroquel xr. it is wonderful. but be sure to have insurance! without my prescription it would be like $500/mo. it works very well for me because i take adderall in the day and this helps me go to sleep at night. great medicine."