"i was on depo provera from the ages of 15-18. pros: not pregnant, no periods at all. cons: i gained 40 pounds. i couldn&#039;t get lubricated for sex very easily. my breasts lost sensitivity. when coming off of depo provera (in hopes to stop steadily gaining weight) i had sexual dreams where i would actually orgasm and they were so painful i would wake up. it felt like my uterus was being crushed and this pain would last anywhere from 15 minutes to an hour. when i told my doctor of this problem she looked at me like i was crazy... the benefits do not make up for the horrible side effects i experienced. not recommended."