"cymbalta is a pretty potent antidepressant. after being on high dose wellbutrin (450mg) with high dose effexor xr (450mg) i was switched to cymbalta. since i&#039;d developed treatment refractory depression, after 3 weeks with no results (and horrible side effects) i asked to be bumped up from 60mg to 90mg. after another 2 weeks, i went to 120mg.  this triggered my first hypomanic episode in my 30-something years.  scaled back down to 60mg and what do you know, this time it worked.  give cymbalta a chance to work, don&#039;t rush it. it may take longer than the usual 3 weeks, but when it works, it&#039;s worth it."