"originally i would have given this drug 10/10. i had anxiety so bad that at one point i could not even leave the house without having a panic attack. on pristiq, from my experience, a few wonderful things will happen: 1. you couldn&#039;t have a panic attack if you tried to talk yourself into it.  2. you will not gain weight (i lost weight originally and then went back to normal after 6 months). 3. your depression will subside - though there is a but with that. the not great: 1. it is really hard to get off of, brain zaps, no step down options. 2. you become a bit zombie-like, lost creativity etc. a lot of not caring so much. 3. sexual side-effects, though they do improve over time. solid 5/10"