"i have been on contrave one pill a day for 1 week and have lost 3 lbs so far.  no lasting side effects except a bit of nausea one day...not sure why.  i have not had a problem with constipation. i think because i make myself almased protein drink for breakfast every morning. as for nausea, a friend has told me to take maitake mushroom supplement.  it has been know to help nausea and weight loss."