"seroquel xr has changed my life! i tried regular seroquel and it&#039;s like having your head in a bucket. the xl version feels like a completely different medicine. i take 100 mg at night. i wake up refreshed, happy, eager to start my day, i also take lamictal 300 mg in the morning. no side effects from either medicine. i have been on both for about 7 years. i have been depressed once in that time and it was situational."