"i have been on pristiq for about 3 weeks. i have had major depression for about 20 years. have been on everything on the market. i also take ativan for anxiety. i am 52 years old and have not had a period for almost 2 years. that has changed. i am going to my doctor to see if this is normal. otherwise i feel great. i have been on paxil for almost 5 years (60mg dose). i now take 50mgs of pristiq. it was very hard transitioning from paxil to pristiq. the withdrawals were bad."