"deplin worked for me but is not for everybody.  i have the genetic mutation which others on this website have talked about, which keeps the body from processing folic acid into l-methylfolate which is needed by the brain for the other neurotransmitters to work properly.  a blood test ($280) proved this.  before deplin i was was on bipolar meds (including seroquel which was miserable) and antidepressants.  now i am only on deplin and clonazepam for chronic anxiety and am feeling re-energized."