"i got the depo shot 1.5 yrs. ago. i was having painful periods due to my endometriosis. i received the shot in my butt and it didn&#039;t hurt. after my 1st shot i had some spotting for a few days. then about 8 weeks in i got a light period for 4 days, but got worse on week 11 and had a regular period (which are normally painful for me). my doctor decided i could get the shot every 6-8 weeks to help with my painful periods &amp; growth of endometriosis. during this time i hadn&#039;t gotten a single period which is good. however, since i&#039;ve been on it for a yr. now &amp; my side effects: fatigue, hot flashes, fatigue, mood swings/anxiety, &amp; weight gain of 25 lbs.! i didnt get my next shot &amp; it&#039;s been 15 weeks since my last shot. no change nor period yet."