"i was on depo for twoish years. the first year was great spotted 3 months in and then never had a period at all. and then beginning mid second year everything changed. my mood swings were though the roof i gained 10-15 lbs i felt depressed. it definitely does the job of preventing pregnancy but the side effects were through the roof. i live an active lifestyle work out 2-5x a week and have been doing weight watchers for 1 year my weight is always up and down but i feel like its a cycle. i get motivated for a few weeks lose a few pounds and then get depressed and stop caring. i talked to my doctor and she does believe it is from depo. so i went back on the pill."