"lamictal has controlled my bipolar type 2 which manifests as depression &amp; hypomania. i never have full blown mania. my gyn dr prescribed  hormone replacement treatment to treat my mood swings. it completely inactivated my lamictal so it was as if i went off it cold turkey. it was the most horrible experience of my life!  my hr increased to 130, my bp to 160/98, my thoughts raced &amp; then i couldn&#039;t focus or make sense &amp; made serious mistakes. i didn&#039;t sleep &gt;15 hours in 5 days and no sleep the last 48 hrs. klonopin saved me when 4 meds failed. just don&#039;t ever drive!! i plan on using uber!! hope this helps someone! as w/all meds will need to adjust &amp; figure out how to taper off. i have an amazing pdoc though &amp; i have strong faith. "