"i am in a clinical research study. i began this in july 2011.  at first i lost a lot of weight quickly (about 15 lbs in 2 months).  i lost 21lbs altogether.  my appetite was nil and my blood pressure went down!  but after about a year, the appetite is back in full swing and blood pressure is going back up.  have also gained 10 pounds back.  also still pre-diabetic.  i guess after a while it stops working.  i have 1 more year to go in the study."