"i have been taking latuda 80 mg for 8 months and am on no other medications for medication induced bipolar disorder which was caused by antidepressants prescribed for anxiety.  latuda should be taken with 350 calories but when i took the medicine with food i was completely engulfed in anxiety within an hour.  now i take it at night with no food.  i sleep for 12 hours at night and feel pretty good but am easily irritated.  i had the genetic testing which indicated that i may be a rapid metabolizer of this medicine so i&#039;m not sure if i am not getting enough of the medicine (because i am not taking it with food) and that is the cause of my irritability or if 80mg is causing irritability. "