"i have recently decided to start wellbutrin after 2 years on zoloft. although i felt the zoloft worked well there were some unfortunate side effects. i asked my doctor if i could give wellbutrin a try (i had also recently picked up smoking again so i mentioned that). well here&#039;s the good news....my mood has remained stable (i simultaneously tapered off the zoloft). i have been better able to focus at work, cigarettes tasted disgusting and i have noticed a decease in my desire to engage in compulsive activities. the cons...food doesn&#039;t really taste all that great, i&#039;m extremely thirsty and i was initially a little on edge at first (this has since gone away). the other surprising effect was a marked improvement in sexual response."