"i broke out with major cystic acne in my early 30s. i used epiduo and it took a while to work but i am acne free today. if i get a cyst i apply epiduo to it and no matter what i don&#039;t touch it. it&#039;s gone in 2-3days. also, i pick at my acne so i realized getting acrylic nails prevent me from pick8ng even if i wanted to. if you do pick on one, wash with soap, dry and apply epiduo. i notice that if i put a thicker layer on that it works better. i love epiduo. it does cause redness but i&#039;d much rather be red than cystic. plus, being female, i can use concealer and base to cover the red. i do use retin-a too."