"i have been taking nucynta for about six months. i am 5&#039;4, 220lb, 42 year old female. this medicine worked very good 6 months ago, still works, but not long enough, and break through pain is stronger and returns faster. side effects for me are dizziness=mild, thirst=severe,voice change=severe, sleepiness=mild, agitation=increased enough to have to say i&#039;m sorry. also a strange eye problem kind of feels like my eyes are yawning, but i am not yawning. "