"i started on venlafaxine several months ago -- went from 37.4 to 75 to150mg. this was situational, as we had lost our 34-year old daughter several years ago in an extremely traumatic accident.   when i was taking 150 mg., i felt less anxious and depressed but foggy-headed, and my emotions have been blunted.  over a short period of time, i experienced excruciating headaches, sleepiness, dry mouth, constipation, bizarre dreams, and felt detached from myself.  under the guidance of my aprn, i&#039;ve been decreasing the dosage.  the weaning process has been difficult, and my memory is terrible.  i have now weaned to 37.5 mg. and will stay at this dose for a while. i have always been extremely sensitive to prescription meds; lower dose makes sense."