"i think opana er is a great pain medication. on a 1-10 pain scale, i went from a 6 with the ms-contin to a 3 with the opana.  i get more done around the house (i can prep, cook, and clean, as i could only do 1 of those things continuously with the ms-contin) so it does its job in that respect, but it has never lasted 12 hours. it seems to wear off in 8 hours on the dot.  and when it wears off, you don&#039;t just hurt, you feel like total crap.  usually you don&#039;t feel like that as soon as a pain medication wears off but with this, you do.  if i get my dosage raised to 3 instead of 2 a day so i don&#039;t have to go through the yucky stage, i can&#039;t help but wonder how i&#039;m going to feel when i come off as i have only been on it for a month."