"after 4 months i thought i was doing quite well on 10mg brintellix until i had very bad headaches.  mri imaging demonstrated i had constricted  blood vessels in my brain a second test showed it had reversed itself. my neurologist strongly advised i discontinue this med because ssri antidepressants can trigger reversible vasoconstriction syndrome which can cause strokes and brain bleeds.  i started wellbutrin xl 150mg which doesn&#039;t target serotoin i&#039;m told.  i&#039;m not doing as well and sometimes think about taking a chance and restarting brintellix and at least have a better quality of life!  depression sucks!"