"i&#039;ve been on effexor xr 75 mg once a day since december 1999. i originally started taking it for depression. it has worked superbly for me.  it removed the frequent crying spells, and feelings of worthlessness, disinterest, etc.  the only side effects i had were yawning at first and vivid dreams (which can still occur).  during the fall, around september/october, i find i double my dose to 150 mg once a day. if i miss my dose, i get weird vertigo-like symptoms.  i can heartily recommend this medication to those with &#039;milder&#039; forms of depression with some anxiety. i don&#039;t care if i have to take it for the rest of my life!  i&#039;m a &#039;normal&#039; human being now!"