"i have only been on pristiq for a week and i can already tell a difference! my only side effects are jaw clenching, thirst, waking up in the middle of the night and weight loss. the jaw clenching is tolerable and if i pay attention to it, i can control it... except when i&#039;m sleeping. the weight loss is awesome. i have been trying for years to lose weight and in 4 days on pristiq, i lost 6 pounds! it really does suppress the appetite. sex is still good, no side effects there. i have been on zoloft (terrible migraines) and lexapro in the past. the zoloft was bad, liked the lexapro, love the pristiq!"