"i have been on 400mg of seroquel xr along with my antidepressant for more than 1 year. initially the medicine worked great for my stress, delusions and helped me sleep well in the night. lately the anxiety has returned and i have severe anxiety during the day time. in the night i pass out so don&#039;t feel much in the night. however this medicine has caused me gain a lot of weight. i would say i have gained about 25 pounds since starting the medicine."