"this is my 6th month on tri sprintec. overall it&#039;s been a positive experience. the first 2 months my breasts hurt - they grew another cup size - but after that there&#039;s been no extra tenderness at all. i didn&#039;t gain any weight, didn&#039;t have any abnormal cravings. didn&#039;t go crazy, no change in libido (still high). my periods were heavier the first 2 months but then evened out; now they&#039;re light and only last 3 to 4 days. i had moderately bad acne around my jaw line and cheeks and it disappeared completely in about a month and a half. it&#039;s been effective against pregnancy. not sure if my regime made a difference: i started taking the pills the 2nd day of my cycle and i take the pill at noon. downsides: stiffness in limbs."