"i used to be on vicodin 10/500 for my severe pain due to rheumatoid arthritis, psoriatic arthritis, fibromyalgia and spinal issues. my pain is chronic and severe. i&#039;ve been on norco for 4 months now and did not feel any difference from the vicodin. last month my pharmacy gave me a different brand. it was amazing! first time in a few years that my pain was less. i even found myself missing a dose because i was feeling ok.  believe me all genetics dont work the same way."