"i started on this medication (37.5 mg) on march 12, 2015 weighing 217. today, august 30, 2015 i weigh 175.  in a few weeks i will begin a much lower dose. there are some negative side effects, dry mouth and constipation being the most annoying but i had no jitters or changes in sleep. i&#039;m 47 and am 5&#039;5 with a goal weight of 140."