"i&#039;ve taken zoloft off and on within the last 3 years. i do much better with it. i went from being so low that i couldn&#039;t take care of myself because of anxiety and depression. with zoloft and better life circumstances i am doing much better. i&#039;m actually happy! right now i&#039;m on 25 milligrams. sometimes i&#039;m on 50. when i had postpartum blues, 100 milligrams was necessary to feel positive."