"in the last 6 months i have had 2 total knee replacement surgeries. my left knee first, right knee 3.6 months later. it is a very painful - actually excruciatingly painful surgery. i have found that percocet 10/325 is the most effective for pain relief after the first 2-3 days, depending on the hospital stay. doctor&#039;s are skittish about prescribing percocet &amp; want to prescribe vicodin which i can&#039;t take because it makes me hyper. i have had problems with some generic oxycodone 10/325 however but the brand is too costly. sometimes pharmacies don&#039;t - won&#039;t carry the 10/325 at all and they are restricted to a monthly quota as well so at the end of the month it can be hard - to fill the rx. wrong for legitimate pain pts."