"as a person who took nexplanon for all three years, yeah it was hell my arm we terrible i was always in pain. it felt like i was pregnant all 3 years, i was experiencing pain in my veins its like i didn&#039;t have good circulation at all. my arms puffed out and cause stretch marks and yeah i went from 170 to 250 and after taking this implant off my arm i lost weight i am not tired, yet its been three week and i still haven&#039;t had my period. i suffer from depression and lots of anxiety mood swings and yes the implant did make it worst... a lot worst to where i had to fill my whole medicine cubby with a lot of meds. but it does work i will tell you that, the only thing that really bothered me was the mood swings and constant yeast infections."