"i have been taking symbyax for 3 weeks. i cannot believe the difference its made in my life. i was always against anti-depressants since all i had tried made me feel worse. i haven&#039;t had energy or motivation like this in, i cant remember how long! it is hard to wake up if i take it too late in the evening. i&#039;m afraid of the weight gain but i think it would be worth it. i am only giving it a 9 since it is so expensive and i have no insurance."