"i have been on seroquel for over 5 years, with varying doses ranging from 50 mg/day to 400 mg/day, for treatment resistent depression initially and bipolar disorder ii recently, and it&#039;s been a gift from god. it doesn&#039;t cause the terrible inner restlessness that older antipsychotics or newer ones like geodon, risperdal, and latuda produce, and it&#039;s effective against bipolar depression. i would give it a 10, but the side effects can be hard to deal with (drowsiness, tachycardia, bp changes)."