"i have been on spironolactone 50 mg a day now since august 2016. after being blessed with clear skin the majority of my adult years, i suddenly was stricken with deep, painful acne, all over my  checks, mouth and forehead. i originally tried doxy for three months with little to no success. transitioning to spiro was the best thing i ever did. warning: it will get worse before it gets better!!! my skin was the worst it ever was the first two weeks starting it. but it slowly started clearing (noticable results within 2 months), and now after 6 months my skin is the best it&#039;s been in years! i take this in conjunction with clindamyacin (which i&#039;ve been on for 10 years). stick with it!!! it will get better!"