"i have been on pristiq for one week for major depression and treatment resistant depression.  i take this medicine at night and have had no side effects yet. i have experienced a major lift in my mood, i am laughing a lot more and in general feel pretty well.  it seems to work quickly and i hope added benefit comes with time, i am glad i decided to try it.  i was scared at 1st because ssri&#039;s in general have always let me down, but this being a ssnri - i think that is the name, i can see a light at the end of the tunnel now."