"so, i&#039;ve been on depo for two years now. and i&#039;ll say, it has been the worst! i&#039;ve gained 12 lbs. i have constant headaches and backaches. i&#039;m very moody. i spot one month after getting the shot up until i get the next shot, then it repeats. i have bad cramps, and lots of hot flashes. i&#039;m getting off the shot next month because this just isn&#039;t the bc for me."