"i am a 27 y/o female, have been battling depression and anxiety for a few years now. as i transition into a nurse, i decided that enough is enough, i can&#039;t keep living my life with this anxiety and unhappiness. st. john&#039;s wort works okay. i didn&#039;t notice a huge change in my mood. i was a little happier, but not much. the anxiety was still the same. the biggest change i noticed was that it made it easier for me to talk to people. i have social anxiety really bad. reason i decided to stop taking it is bc one night i had super bad anxiety so i took a xanax and it completely canceled out the effect of my xanax. went into a full blown panic attack, had to call into work. this drug has a a lot of interactions with other meds. will be going on ssri"