how many times can you spot the letter a in:
we also need to determine if its mechanism of action is the same in human cells as it is in mouse cells. (7)?several clinically relevant questions remain. cytokines and immune regulation immune protection is orchestrated as a balanced interplay of events without triggering timegadine aberrant responses to self or foreign antigens that underlie autoimmunity, allergies, chronic infections, and cancer. these varied responses timegad disease fighting capability. these cytokines differ within their appearance patterns, cellular resources, signaling circuits, and goals of suppression (yoshimoto and yoshimoto 2013). they action in concert for maximal suppressive potential typically, although different associates may be pretty much active under homeostatic or diverse inflammatory scenarios. tgf is extremely expressed generally in most tissue under basal circumstances (li among others 2012). tgf signaling is indispensible for limiting t-cell reactivity to maintenance and personal of steady-state immune system homeostasis and tolerance. hence, mice with germ series tgf deletion or t-cell-specific insufficiency in the tgf receptor develop spontaneous multifocal inflammatory disease connected with exuberant t-cell activation and timegadine th1/th2 cytokine discharge (shull timegadine among others 1992; flavell and li 2008; timegadine tran 2012). the same holds true for sufferers with sezary symptoms whose compact disc4+ t cells possess reduced.
user
In that passage, there are 91 occurrences of the letter "a."
assistant