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participation of gabaergic systems in the production of antinociception by various stresses in mice.
based on the data that diazepam, a benzodiazepine (bzp) receptor agonist, antagonized psychological (psy)-stress induced analgesia (sia) without prominent action on footshock (fs)- and forced swimming (sw)-sia and that bzp receptors are coupled with gaba receptors, we examined how the gabaergic system participates in the production of various sias. muscimol, a gabaa receptor agonist, at doses of 0.25 to 1.0 mg/kg, affected each sia differently, suppressed psy-sia at 0.25 mg/kg but tended to potentiate it at 1.0 mg/kg, potentiated sw-sia dose-dependently and did not affect fs-sia at the doses employed. both bicuculline, a gabaa receptor antagonist, 0.5 to 2.0 mg/kg, and picrotoxin, a cl- channel blocker, 0.25 to 1.0 mg/kg, dose-dependently suppressed psy- and fs-sia. meanwhile, the effects of both drugs on sw-sia were less than those on psy- and fs-sia, namely, bicuculline slightly inhibited it only at 2.0 mg/kg, and picrotoxin did not produce any appreciable effect even at the highest dose. baclofen, a gabab receptor agonist, at 5.0 and 10.0 mg/kg had no influence on each sia. on the contrary, cgp 35348, a gabab receptor antagonist at 20 to 100 mg/kg caused the dose-dependent blockade of fs-sia, but affected neither psy- nor sw-sia. the production of psy- and sw-sia is attributable to the gabaa receptors/cl- channel mediated mechanism alone, while that of fs-sia involves both gabaa and gabab receptor mediated systems. thus, gabaergic systems play an important role in the production of each sia; however, the participation of the receptor subtypes in the mechanism was different from each other.
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The given text has one hundred and thirty-three "a"s.
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