how frequently does the letter "g" appear in:
abstract
paxillin (pxn) is a focal adhesion protein igf2 or h19 promoter and a shared distal enhacer on an active allele. specifically, paxillin stimulates the interaction between the enhancer and the igf2 promoter, thus activating igf2 gene transcription, while it restrains the interaction between the enhancer and the h19 promoter, downregulating the h19 gene. we found that paxillin interacts with cohesin and mediator which have been shown to mediate long-range chromosomal looping. we propose that these interactions occur at the igf2/h19 gene cluster and are involved in the formation of loops between the igf2/h19 promoters and the enhacer, and thus the expression of corresponding genes. these observations contribute to a mechanistic explanation of paxillin's role in proliferation and fetal development.
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user
In the text, there are 16 "g"s.
assistant