what's the number of times the letter "h" appears in:
j med chem. 1995 jul 7;38(14):2557-69.
novel inhibitors of the nuclear factor of activated t cells (nfat)-mediated transcription of beta-galactosidase: potential immunosuppressive and antiinflammatory agents.
michne wf1, schroeder jd, guiles jw, treasurywala am, weigelt ca, stansberry mf, mcavoy e, shah cr, baine y, sawutz dg, et al.
department of biochemistry, sterling winthrop pharmaceuticals research division, collegeville, pennsylvania 19426, usa.
the preparation of a series of quinazoline-2,4-diones, 1-3, and pyrrolo[3,4-d]pyrimidine-2,4-diones, 4-8 is described. a small number of quinazolinedione analogs were identified from random screening to possess low micromolar (1.3-4.4 microm) potency in the nuclear factor of activated t cells-1-regulated beta-galactosidase expression assay. an expanded analog search resulted in identifying pyrrolopyrimidinedione 4b which is 5-10-fold (0.26 microm) more potent than the quinazolinediones. replacement of the benzyl group with naphthyl led to greater potency and conformationally restricted analogs 4u-w. the naphthyl and acenaphthyl analogs are 10-100 times more potent inhibitors of beta-galactosidase expression than 4b. binding affinity data for displacement of radiolabeled 4s from jurkat cell membranes reflected an excellent correlation with the ic50 value for inhibition of beta-galactosidase activity. these products, whose structure-activity relationships are discussed, are of interest as potential agents for preventing interleukin-2 gene transcription.

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In that passage, there are 35 occurrences of the letter "h."
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