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cingal cross-linked hyaluronic acid with ancillary triamcinolone hexacetonide is a single, intra-articular injection into the synovial cavity of a human joint to relieve the symptoms of osteoarthritis.
cingal is ce mark indicated as a viscoelastic supplement or a replacement for synovial fluid in human joints. cingal is well suited for rapid and long term relief of the symptoms of human joint dysfunctions such as osteoarthritis. the actions of cingal are long term relief of symptoms by lubrication and mechanical support supplemented by short-term pain relief provided by triamcinolone hexacetonide.
in canada, cingal is indicated for the treatment of pain in osteoarthritis (oa) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and to simple analgesics (e.g. acetaminophen). cingal includes an ancillary steroid to provide additional short term pain relief.
cingal is injected through a sterile, disposable, hypodermic needle of suitable gauge into the selected joint space. the sterile needle should be attached to the cingal syringe by a health care professional using health care facility approved aseptic technique. recommended needle size for injections into the knee is 18-21 gauge. the final needle selection for any procedure is determined by the physician. the health care provider should ensure proper penetration into joint synovial space prior to injecting cingal.
the safety of cingal in pregnant and lactating women has not been established.
hyaluronic acid is a naturally-occurring component of the tissues of the body. cingal is thoroughly tested to determine that each batch conforms to the product quality attributes. mild to moderate episodes of transient swelling and discomfort have occasionally been observed following intra-articular injection of hyaluronic acid preparations. a risk of infection is possible with the procedure of injecting substances into joints.
adverse effects depend on the dose and the duration of treatment. systemic adverse effects are rare, but may occur as a result of repeated periarticular injection. as with other intraarticular steroid treatments, transient adrenocortical suppression has been observed during the first week after injection. this effect is enhanced if corticotropin or oral steroids are used concomitantly.
common adverse effects include local reactions, including sterile abscesses, post-injection erythema, pain, swelling and necrosis at the injection site.
rare adverse effects include vertigo and excess dosage or too-frequent administration of injections into the same site causing local subcutaneous atrophy, which, due to the properties of the drug, will only return to normal after several months.
very rare adverse effects include anaphylaxis-type reactions, thromboembolism, hyperpigmentation or hypopigmentation, calcinosis and tendon rupture.
effects on endocrine disorders, psychiatric disorders, nervous system disorders, eye disorders, cardiac disorders, vascular disorders, gastrointestinal disorders, skin and subcutaneous tissue disorders, musculoskeletal and connective tissue disorders, and renal and urinary disorders are not known.
we are anika therapeutics, a global medical technology company specializing in therapeutics based on its proprietary hyaluronic acid (ha) technology. we are committed to improving the lives of patients with degenerative orthopedic diseases and traumatic conditions by providing clinically meaningful therapeutic pain management solutions along the continuum of care, from palliative care to regenerative medicine. with over 20 million procedures performed over the past twenty years utilizing our proprietary technology, anika is helping individuals all over the world return to life naturally.
cingal® is a registered trademark of anika therapeutics, inc., bedford, ma 01730 u.s.a.
information applies exclusively to territories outside of the usa. cingal is currently not approved for use in the usa.
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I found one hundred and fifty-three "l"s in the provided passage.
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