can you count the letter l in:
june 1997
in is now clear that successful combination therapy depends on two interrelated factors: a high degree of compliance on the part of the patient, and a high degree of suppression on the part of the regimen. whenever suppression of viral replication begins to falter, either because the patient is only fitfully compliant with therapy or because the virus has begun to develop resistance to one or more of the drugs the patient is taking, the clinician must intervene -- before high-level resistance renders therapy ineffective.
in their article on the problem of protease resistance, drs. steven g. deeks and james o. kahn analyze this diagnostic dilemma and conclude that certain protease inhibitors may make a better choice for initial antiretroviral therapy (see the problem of protease resistance). the resistance data these authors present suggest that all of the currently available combination therapies will eventually fail. with that inevitability in mind, clinicians should think in terms of successive antiretroviral regimens,. that back-up regimen might well include one of the investigational drugs discussed by dr. harold a. kessler in the next generation of antiretroviral agents. although several of these compounds hold considerable clinical promise, all of them will require a high level of compliance on the part of patients, lest resistance develop to these drugs as well.
as dr. margaret a. chesney observes in compliance: how you can help,.
given the effort that so many of our patients daily routines, by encouraging compliance in every encounter with every patient, and by providing patients with tools that will help them achieve and maintain a high level of compliance. to assist practitioners in this crucial task, we have provided a number of helpful suggestions in the pull out and save feature in this issue.
paul a. volberding, m.d., is editor-in-chief of hiv newsline and aids program director at san francisco general hospital.
user
There are 82 "l"s in the text you provided.
assistant