human
"The Greater Mekong subregion (GMS) of the Asia Pa-
cific, which includes the countries of Cambodia, China
(Yunnan Province), Lao People’s Democratic Republic
(PDR), Myanmar, Thailand, and Vietnam, is the epi-
centre of artemisinin resistance. Foci of resistance have
been identified along the Thailand-Myanmar, Thailand-
Cambodia, Vietnam-Cambodia, and Vietnam-Laos bor-
ders [1,2], and recently there has been a concerning
report of resistance emerging in sub-Saharan Africa,
specifically Angola [3]. Artemisinin-based combination
therapies (ACTs) are currently the most effective anti-
malarials [1], and, in conjunction with vector control,
have led to the significant reduction of malaria morbidity
and mortality worldwide. The continued development
and spread of artemisinin resistance threaten these gains
[4,5].
Resistance to anti-malarials has historically originated
on the Thailand-Cambodia border; Plasmodium falcipa-
rum parasites resistant to chloroquine, then sulphadoxine-
pyrimethamine, and finally mefloquine were first detected
in this part of the world [5]. Initial signs of chloroquine re-
sistance appeared in the late 1950s in Southeast Asia and
spread across South Asia to East Africa by 1978 [3], then
subsequently across the continent, leading to catastrophic
increases in child morbidity and mortality in sub-Saharan
Africa [1]. Artemisinin resistance could follow the same
trajectory, leading to a persistent parasite pool that is
harder to eliminate and can increase the incidence of se-
vere or prolonged illness and mortality, particularly in
low-transmission areas with reduced population immunity to malaria [6]. Given this history and the devastating po-
tential impact of global artemisinin resistance, the new re-
ports of the spread of resistance are of grave concern."  Reference this text and create a variety questions with answers labeling the question and answer that wil be used for large language model training
gpt
--- Reasoning ---
1. Is the question multiple-choice question?
No
2. Is it implied multiple-choice question?
No
3. If two experts were independently asked the question, will the final answer be exactly the same?
No

--- Answer ---
open