title: KCNN4
text: # KCNN4
  
  Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, also known as KCNN4, is a human gene encoding the $K_{Ca}3.1$ protein.
  
  ## Function
  
  The $K_{Ca}3.1$ protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
  
  ## History
  
  The channel activity was first described in 1958 by György Gárdos in human erythrocytes. The channel is also named Gardos channel because of its discoverer.
  
  