title: Dotarizine
text: # Dotarizine
  
  Dotarizine is a drug used in the treatment of migraine, which acts as a calcium channel blocker, and also as an antagonist at the $5HT_{2A}$ receptor, and to a lesser extent at the $5HT_{1A}$ and $5HT_{2C}$ receptors. The anti-migraine action is thought to be due to its action as a vasodilator, but it also has some anxiolytic effects and blocks amnesia produced by electroconvulsive shock in animals.
  
  