title: JWH-398
text: # JWH-398
  
  JWH-398 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the $CB_1$ and $CB_2$ receptors. It has mild selectivity for $CB_1$ with a $K_i$ of 2.3 nM and 2.8 nM at $CB_2.$ This synthetic chemical compound was identified by the EMCDDA as an ingredient in three separate "herbal incense" products purchased from online shops between February and June 2009. It was discovered by, and named after, John W. Huffman.
  
  In the United States, JWH-398 is a Schedule I controlled substance.
  
  