title: JWH-370
text: # JWH-370
  
  JWH-370 ([5-(2-methylphenyl)-1-pentylpyrrol-3-yl]-naphthalen-1-ylmethanone) is a synthetic cannabinoid from the naphthoylpyrrole family which acts as an agonist of the $CB_1$ $(K_i$ = 5.6 ± 0.4nM) and $CB_2$ $(K_i$ = 4.0 ± 0.5nM) receptors, with a slight selectivity for the $CB_2$ receptor. JWH-370 was first synthesized in 2006 by John W. Huffman and colleagues to examine the nature of ligand binding to the $CB_1$ receptor.
  
  ## Legality
  
  In the United States JWH-370 is not federally scheduled, although some states have passed legislation banning the sale, possession, and manufacture of JWH-370.
  
  In Canada, JWH-370 and other naphthoylpyrrole-based cannabinoids are Schedule II controlled substances under the Controlled Drugs and Substances Act.
  
  In the United Kingdom, JWH-370 and other naphthoylpyrrole-based cannabinoids are considered Class B drugs under the Misuse of Drugs Act 1971.
  
  