title: S-444,823
text: # S-444,823
  
  S-444,823 is a drug developed by Shionogi which is a cannabinoid agonist. It was developed as an antipruritic, and has moderate selectivity for the $CB_2$ subtype, having a $CB_2$ affinity of 18nM, and 32x selectivity over the $CB_1$ receptor. In animal studies it showed analgesic effects and strongly reduced itching responses, but without producing side effects such as sedation and catalepsy that are seen with centrally acting $CB_1$ agonists.
  
  