title: S-777,469
text: # S-777,469
  
  S-777,469 is a drug developed by Shionogi which is a cannabinoid receptor agonist, with 128x selectivity for the $CB_2$ subtype, having a $CB_2$ affinity of 36nM, and a $CB_1$ affinity over 4600nM.
  
  In animal studies it showed antipruritic effects, and passed Phase II human trials for the treatment of atopic dermatitis, but development was ultimately not continued further.
  
  