title: GPD1L
text: # GPD1L
  
  GPD1L is a human gene. The protein encoded by this gene contains a glycerol-3-phosphate dehydrogenase (NAD+) motif and shares 72% sequence identity with GPD1.
  
  ## Structure
  
  GPD1L contains the following domains:
  
  * N-terminal – NAD+ consensus binding site
  * a site homologous to the cardiac sodium channel SCN5A
  * C-terminal lysine-206 residue
  
  ## Tissue distribution
  
  Northern blot analysis detected a single GPD1L transcript in all tissues examined except liver. Highest expression was in heart and skeletal muscle.
  
  ## Disease linkage
  
  Mutations in the GPD1L gene are associated with the Brugada syndrome and sudden infant death syndrome.
  
  