title: JWH-116
text: # JWH-116
  
  JWH-116 is a synthetic cannabinoid receptor ligand from the naphthoylindole family. It is the indole 2-ethyl derivative of related compound JWH-018. The binding affinity of JWH-116 for the $CB_1$ receptor is reported as $K_i$ = 52 ± 5 nM.
  
  In the United States, all $CB_1$ receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-116 are Schedule I Controlled Substances.
  
  