title: KvLQT2
text: # KvLQT2
  
  $K_v7.2$ (KvLQT2) is a voltage- and lipid-gated potassium channel protein coded for by the gene KCNQ2.
  
  It is associated with benign familial neonatal epilepsy.
  
  ## Function
  
  The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
  
  ## Ligands
  
  * ICA-069673: channel opener at KCNQ2/Q3, 20-fold selective over KCNQ3/Q5, no measurable activity against a panel of cardiac ion channels (hERG, Nav1.5, L type channels, and KCNQ1) and no activity on $GABA_A$ gated channels at 10 μM. A range of related benzamides exhibited activity, of which compound number 40 is shown here.
  * ML252: channel inhibitor, $IC_{50}$ = 70nM.
  * Phosphatidylinositol 4,5-bisphosphate $(PIP_2)$
  