title: Growth delay-hydrocephaly-lung hypoplasia syndrome
text: # Growth delay-hydrocephaly-lung hypoplasia syndrome
  
  Growth delay-hydrocephaly-lung hypoplasia syndrome, also known as Game-Friedman-Paradice syndrome is a very rare hereditary disorder which is characterized by developmental, lung, and brain anomalies. Only 4 cases have been reported in medical literature.
  
  ## Signs and symptoms
  
  The following is a list of the symptoms usually shown by fetuses with the disorder:
  
  * Delayed fetal growth
  * Hydrocephaly
  * Sylvius patent aqueduct
  * Micrognathia
  * Poorly developed (hypoplastic) lungs
  * Malrotated intestines
  * Omphalocele
  * Shortening of the lower limbs
  * Tibia bowing
  * Generalized foot abnormalities
  
  ## History
  
  It was first discovered in 1989, by Game et al. when they described 4 fetus siblings (3 females, 1 male) born to healthy, non-consanguineous parents with all the symptoms mentioned above. The siblings were terminated and all of them (post-mortem examination) had a size similar to fetuses of younger gestational age.
  
  