title: CRZ1
text: # CRZ1
  
  CRZ1, short for Calcineurin-Responsive Zinc Finger 1, is a transcription factor that regulates calcineurin dependent-genes in Candida albicans.
  
  ## Mechanism of action
  
  The cytoplasmic protein Crz1 is dephosphorylated by the calcineurin and is then targeted to the nucleus. The nuclear protein activates the transcription of genes involved in cell-wall maintenance and ion homeostasis.
  
  ## Structure
  
  The protein Crz1 possesses a Zinc-Finger motif that binds to a specific motif called CDRE (Calcineurin-Dependent Response Element) present on the promoter of the targeted genes. It also possesses a nuclear localization signal (NLS) at the N-terminal part
  
  