title: HCN1
text: # HCN1
  
  Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 is a protein that in humans is encoded by the HCN1 gene.
  
  ## Function
  
  Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.
  
  ## Tissue distribution
  
  HCN1 channel expression is found in the sinoatrial node, the neocortex, hippocampus, cerebellar cortex, dorsal root ganglion, trigeminal ganglion and brainstem.
  
  ## Ligands
  
  * Ketamine is an inhibitor of HCN1 in addition to its other targets.
  * Propofol also inhibits HCN1.
  * Isoflurane and Sevoflurane inhibit HCN1.
  
  ## Interactions
  
  HCN1 has been shown to interact with HCN2.
  
  ## Epilepsy
  
  De novo mutations in HCN1 cause epilepsy.
  
  