title: FUB-APINACA
text: # FUB-APINACA
  
  FUB-APINACA (also known as A-FUBINACA according to the EMCCDA framework for naming synthetic cannabinoids and FUB-AKB48) is an indazole-based synthetic cannabinoid that is presumed to be a potent agonist of the $CB_1$ receptor and has been sold online as a designer drug. It is an analog of APINACA and 5F-APINACA where the pentyl chain has been replaced with fluorobenzyl.
  
  ## Pharmacology
  
  FUB-APINACA acts as a full agonist with a binding affinity of 1.06 nM at $CB_1$ and 0.174 nM at $CB_2$ cannabinoid receptors.
  
  ## Legal status
  
  In the United States, FUB-APINACA was temporarily emergency scheduled by the DEA in 2019. and made a permanent Schedule I Controlled Substance nationwide on April 7, 2022. Previously, it was illegal only in Alabama (listed as FUB-AKB48).
  
  Sweden's public health agency suggested classifying FUB-APINACA as a hazardous substance on November 10, 2014.
  
  