title: Tiamenidine
text: # Tiamenidine
  
  Tiamenidine (BAN, USAN, INN, also known as thiamenidine, Hoe 440) is an imidazoline compound that shares many of the pharmacological properties of clonidine. It is a centrally-acting $α_2$ adrenergic receptor agonist $(IC_{50}$ = 9.1 nM). It also acts as an $α_1-adrenergic$ receptor agonist to a far lesser extent $(IC_{50}$ = 4.85 μM). In hypertensive volunteers, like clonidine, it significantly increased sinus node recovery time and lowered cardiac output. It was marketed (as tiamenidine hydrochloride) by Sanofi-Aventis under the brand name Sundralen for the management of essential hypertension.
  
  ## Synthesis
  
  Reaction of thiourea 1 with methyl iodide gives the corresponding S-methyl analogue (2), followed by heating with ethylenediamine, completes the synthesis of tiamenidine (3).
  
  