title: DAT (chemotherapy)
text: # DAT (chemotherapy)
  
  DAT in the context of chemotherapy is an acronym that means a chemotherapy regimen most often used as an induction regimen in acute myelogenous leukemia, usually for those who are refractory to the standard "7+3" induction regimen or who has relapsed. But this regimen also can be used as primary, first-line induction therapy.
  
  The DAT regimen consists of:
  
  * (D)aunorubicin - an anthracycline antibiotic that is able to intercalate DNA, thus disrupting cell division and preventing mitosis;
  * (A)ra-C (cytarabine) - an antimetabolite;
  * (T)hioguanine - another antimetabolite.
  
  ## Dosing regimen
  
  | Drug | Dose | Mode | Days |
  | - | - | - | - |
  | Ara-C (cytarabine) | 200 $mg/m^2$ | IV push every 12 hours in 2 divided doses (100 $mg/m^2$ each) | Days 1-10 |
  | Daunorubicin | 50 $mg/m^2$ | IV slow push | Days 1, 3 and 5 |
  | Thioguanine | 200 $mg/m^2$ | PO every 12 hours in 2 divided doses (100 $mg/m^2$ each) | Days 1-10 |
  