title: AMG 319
text: # AMG 319
  
  AMG 319 is a drug developed by Amgen which acts as an inhibitor of the phosphoinositide 3-kinase enzyme subtype PI3Kδ. It was originally developed as an anti-inflammatory drug with potential applications in the treatment of autoimmune conditions such as rheumatoid arthritis, but subsequent research showed that it inhibits cell proliferation and might potentially have useful anti-cancer effects, and it has been put into clinical trials to assess its safety and tolerability in this application.
  
  ## Mechanism(s) of action
  
  It is a potential immunotherapy because blocking PI3Kδ (PI3K p110δ) eliminates a group of inhibitory immune cells and may allow the immune system to better attack the cancer cells. p110δ inactivation in regulatory T  cells unleashes $CD8^+$ cytotoxic T  cells.
  
  ## Clinical trials
  
  Its first clinical trial was a phase I/II study in adults with relapsed or refractory lymphoid malignancies. This was due to run from 2011 to 2013.
  
  In 2015/16 it started a phase II clinical trial as a neoadjuvant therapy for human papillomavirus (HPV) negative head and neck squamous-cell carcinoma (HNSCC) (prior to resection surgery).
  
  