title: Transportin-3
text: # Transportin-3
  
  Transportin-3 is a protein that in humans is encoded by the TNPO3 gene.
  
  ## Function
  
  TNPO3 is a nuclear import receptor for serine/arginine-rich (SR) proteins, including Serine/arginine-rich splicing factor 1, which are essential precursor-mRNA splicing factors.
  
  ## Clinical significance
  
  The TNPO3-IRF5 locus is implicated in primary biliary cirrhosis and systemic sclerosis.
  
  