title: Naked cuticle 2
text: # Naked cuticle 2
  
  Naked cuticle 2 (NKD2) is a human gene that encodes the protein Nkd2, one of the Naked cuticle (Nkd) family of proteins that regulate the Wnt signaling pathway. Both Nkd1 and Nkd2 proteins can bind to Dishevelled proteins (DVL1, DVL2, DVL3), but only Nkd2 can bind to the EGF-ligand family member TGF alpha and regulate its polarized secretion in cultured epithelial cells.
  
  ## Sources
  
  * ↑ Wharton, KA Jr; Zimmermann, G; Rousset, R; Scott, MP (Jun 2001). "Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling". Dev. Biol. 234 (1): 93–106. doi:10.1006/dbio.2001.0238. PMID 11356022. S2CID 18903944.
  * ↑ Katoh, M (Nov 2001). "Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2". Int J Oncol. 19 (5): 963–9. doi:10.3892/ijo.19.5.963. PMID 11604995.
  * ↑ Li, C; Franklin, JL; Graves-Deal, R; Jerome, WG; Cao, Z; Coffey, RJ (Apr 2004). "Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells". Proc Natl Acad Sci U S A. 101 (15): 5571–6. Bibcode:2004PNAS..101.5571L. doi:10.1073/pnas.0401294101. PMC 397424. PMID 15064403.
  