title: E-6837
text: # E-6837
  
  E-6837 is an orally active, $5-HT_6$ agonist developed in an attempt to create an anti-obesity medication. In cell lines expressing rat $5-HT_6$ receptors, it acted as a partial agonist (on presumed silent receptors), while it acted as a full agonist on human $5-HT_6$ receptors (which are constitutively active). Oral administration of E-6837 reduced food intake, but only transiently. In rats, twice daily administration of E-6837 over the course of 4 weeks resulted in a 15.7% reduction in body weight, compared to 11% reduction for sibutramine. This weight loss remained significant for E-6837 after a 43-day withdrawal period, whereas the weight difference was non-significant for sibutramine (i.e., sibutramine had a rebound effect while E-6837 did not), and this weight loss was found to be due to a loss of fat mass. The reduction in fat mass in E-6837 treated animals was associated with a 50% decrease in plasma leptin levels, and also reduced glucose and insulin levels in plasma after a glucose tolerance test. This indicates that weight loss from E-6837 is associated with improved insulin sensitivity, and thus, better glycemic control.
  
  One proposed mechanism of action is that E-6837 acts on neurons in the hypothalamus, which has shown significant levels of $5-HT_6$ receptor mRNA. The hypothalamus is one key structure involved in regulating food intake.
  
  