title: RDBP
text: # RDBP
  
  Negative elongation factor E is a protein that in humans is encoded by the RDBP gene.
  
  ## Function
  
  The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC class III) region on chromosome 6.
  
  ## Interactions
  
  RDBP has been shown to interact with:
  
  * Cofactor of BRCA1,
  * TH1L, and
  * WHSC2.
  