title: Naphthoylindoles
text: # Naphthoylindoles
  
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  Naphthoylindoles are a class of synthetic cannabinoids.
  
  ## Pharmacology
  
  Behaving similarly in vivo to endocannabinoids such as anandamide or 2-arachidonoylglycerol (2-AG), Naphthoylindoles can bind to endocannabinoid receptors in animals, presenting as $CB_1$ and/or $CB_2$ partial/full agonists.
  
  ## History
  
  They have gained notoriety over the years for illicit usage and distribution in Europe and North America, typically marketed as "herbal incense blends."
  
  