title: 3-Methyl-19-methyleneandrosta-3,5-dien-17β-ol
text: # 3-Methyl-19-methyleneandrosta-3,5-dien-17β-ol
  
  3-Methyl-19-methyleneandrosta-3,5-dien-17β-ol is a synthetic, steroidal estrogen and a selective agonist of the ERβ. It was discovered serendipitously and was the lead compound among a series of androsta-3,5-dienes as ERβ ligands. Its affinity $(IC_{50})$ for the ERβ was found to be 9 nM and it showed 62- and 160-fold binding selectivity for this receptor over the AR and the ERα, respectively. The $EC_{50}$ of the compound for the ERβ was found to be 69 nM and its intrinsic activity was 92% (relative to that of estradiol). As such, it is a potent ERβ agonist with high affinity and selectivity.
  
  