title: Leconotide
text: # Leconotide
  
  Leconotide (INN; development codes CNSB004 and AM336; also known as ω-conotoxin CVID) is an ω-conotoxin peptide isolated from the venom of Conus catus which is under investigation as an analgesic drug for the treatment of pain conditions.
  
  It acts as an N-type voltage-gated calcium channel $(Ca_v2.2)$ blocker and is highly selective for this channel over the related P/Q-type voltage-gated calcium channel $(Ca_v2.1).$
  
  Relative to ziconotide, leconotide is advantageous in that it is significantly less toxic, and for that reason can be administered intravenously as opposed to via intrathecal injection.
  
  