title: Phosphoribosyl-N-formylglycineamide
text: # Phosphoribosyl-N-formylglycineamide
  
  Phosphoribosyl-N-formylglycineamide (or FormylGlycinAmideRibotide, FGAR) is a biochemical intermediate in the formation of purine nucleotides via inosine-5-monophosphate, and hence is a building block for DNA and RNA. The vitamins thiamine and cobalamin also contain fragments derived from FGAR.
  
  FGAR is formed when the enzyme phosphoribosylglycinamide formyltransferase adds a formyl group from 10-formyltetrahydrofolate to glycineamide ribonucleotide (GAR) in reaction EC 2.1.2.2:
  
      GAR + 10-formyltetrahydrofolate → FGAR + tetrahydrofolate
  
  The biosynthesis pathway next converts FGAR to an amidine by the action of phosphoribosylformylglycinamidine synthase (EC 6.3.5.3), transferring an amino group from glutamine and giving 5'-phosphoribosylformylglycinamidine (FGAM) in a reaction that also requires ATP:
  
      FGAR + ATP + glutamine + $H_2O$ → FGAM + ADP + glutamate + Pi
  