title: O6-Benzylguanine
text: # O6-Benzylguanine
  
  $O^6-Benzylguanine$ (O6-BG) is a synthetic derivative of guanine. It is an antineoplastic agent. It exerts its effect by acting as a suicide inhibitor of the enzyme O6-alkylguanine-DNA alkyltransferase which leads to interruption of DNA repair. O6-BG was used clinically in combination with the alkylating agent temozolomide for glioblastoma, however the combination was found to be overly toxic without adding significant benefit.
  
  O6-BG is also used as a biochemical tool in the study of DNA repair mechanisms.
  
  