title: HAZMAT Class 6 Toxic and infectious substances
text: # HAZMAT Class 6 Toxic and infectious substances
  
  Poisonous material is a material, other than a gas, known to be so toxic to humans that it presents a health hazard during transportation.
  
  ## Divisions
  
  Division 6.1: Poisonous material is a material, other than a gas, which is known to be so toxic to humans as to afford a hazard to health during transportation, or which, in the absence of adequate data on human toxicity:
  
  * Is presumed to be toxic to humans because it falls within any one of the following categories when tested on laboratory animals (whenever possible, animal test data that has been reported in the chemical literature should be used):
  
     * Oral Toxicity: A liquid or solid with an LD50 for acute oral toxicity of not more than 300 mg/kg.
  
     * Dermal Toxicity. A material with an LD50 for acute dermal toxicity of not more than 1000 mg/kg.
  
     * Inhalation Toxicity: A dust or mist with an LC50 for acute toxicity on inhalation of not more than 4 mg/L; or a material with a saturated vapor concentration in air at 20 °C (68 °F) of more than one-fifth of the LC50 for acute toxicity on inhalation of vapors and with an LC50 for acute toxicity on inhalation of vapors of not more than 5000 $mL/m^3;$ or
  * Is an irritating material, with properties similar to tear gas, which causes extreme irritation, especially in confined spaces.
  
  Division 6.2: Biohazards.
  
  ## Placards
  
  * Hazardous Materials
  * Class 6.1: Poison
  * Hazardous Materials
  * Class 6.2: Biohazard
  * Hazardous Materials
  * Class 6: Packing Group III
  * Hazardous Materials
  * Class 6: Toxic
  * Poison: 454 kg (1001 lb) or more gross weight of poisonous materials that are not in Hazard Zone A or B (see Assignment of packing groups and hazard zones below). For U.S. Domestic Use only.
  * Inhalation Hazard: Any quantity of a material that is in Hazard Zone A or B (see Assignment of packing groups and hazard zones below).
  * Toxic: May be used instead of POISON placard on 454 kg (1001 lb) or more gross weight of poisonous materials that are not in Hazard Zone A or B (see Assignment of packing groups and hazard zones below). For international shipments the label must say Toxic if it will be worded.
  * PG III (Packing Group III): May be used instead of POISON placard on 454 kg (1001 lb) or more gross weight of Poison PG III materials (see Assignment of packing groups and hazard zones below).
  
  ## Lethality
  
  ### Lethal Dose 50
  
  * Oral Toxicity: $LD_{50}$ for acute oral toxicity means that dose of the material administered to both male and female young adult albino rats which causes death within 14 days in half the animals tested. The number of animals tested must be sufficient to give statistically valid results and be in conformity with good pharmacological practices. The result is expressed in mg/kg body mass.
  * Dermal Toxicity: $LD_{50}$ for acute dermal toxicity means that dose of the material which, administered by continuous contact for 24 hours with the shaved intact skin (avoiding abrading) of an albino rabbit, causes death within 14 days in half of the animals tested. The number of animals tested must be sufficient to give statistically valid results and be in conformity with good pharmacological practices. The result is expressed in mg/kg body mass.
  * Determining Acute $LD_{50}$
  * For purposes of classifying and assigning packing groups to mixtures possessing oral or dermal toxicity hazards according to the criteria in 49CFR 173.133(a)(1), it is necessary to determine the acute LD50 of the mixture. If a mixture contains more than one active constituent, one of the following methods may be used to determine the oral or dermal LD50 of the mixture:
  * Obtain reliable acute oral and dermal toxicity data on the actual mixture to be transported;
  * If reliable, accurate data is not available, classify the formulation according to the most hazardous constituent of the mixture as if that constituent were present in the same concentration as the total concentration of all active constituents; or
  * If reliable, accurate data is not available, apply the formula:
  * ${\tfrac {C_{A}}{T_{A}}}+{\tfrac {C_{B}}{T_{B}}}+{\tfrac {C_{Z}}{T_{Z}}}={\tfrac {100}{T_{M}}}$
  * where:
  * $C$= the percent concentration of constituent A, B ... Z in the mixture;
  * $T$ = the oral LD50 values of constituent A, B ... Z;
  * $T_{M}$ = the oral LD50 value of the mixture.
  
  ### Lethal Concentration 50
  
  $LC_{50}$ for acute toxicity on inhalation means that concentration of vapor, mist, or dust which, administered by continuous inhalation for one hour to both male and female young adult albino rats, causes death within 14 days in half of the animals tested. If the material is administered to the animals as a dust or mist, more than 90 percent of the particles available for inhalation in the test must have a diameter of 10 micrometres or less if it is reasonably foreseeable that such concentrations could be encountered by a human during transport. The result is expressed in mg/L of air for dusts and mists or in $mL/m^3$ of air (parts per million) for vapors. See 49CFR 173.133(b) for LC50 determination for mixtures and for limit tests.
  
  ## Compatibility table
  
  Load and Segregation Chart :
  
  | | Weight | Weight | 1.1 | 1.2 | 1.3 | 1.4 | 1.5 | 1.6 | 2.1 | 2.2 | 2.2 | 2.3 | 2.3 | 3 | 4.1 | 4.2 | 4.3 | 5.1 | 5.2 | 6.1 | 7 | 8 |
  | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
  | | Weight | Weight | 1.1 | 1.2 | 1.3 | 1.4 | 1.5 | 1.6 | 2.1 | 2.2 | 2.2 | A | B | 3 | 4.1 | 4.2 | 4.3 | 5.1 | 5.2 | A | 7 | 8 |
  | 6.1A | Any Quantity | E | | | | O | | | O | | | | | | | | | | | | | |
  | Key |||||||||||||||||||||||
  | The absence of any hazard class or division or a blank space in the table indicates that no restrictions apply. X: These materials may not be loaded, transported, or stored together in the same transport vehicle or storage facility during the course of transportation. O: Indicates that these materials may not be loaded, transported or stored together in the same transport vehicle or storage facility during the course of transportation, unless separated in a manner that, in the event of leakage from packages under conditions normally incident to transportation, commingling of hazardous materials would not occur. E: Packages with "Poison" or "Poison Inhalation Hazard" markings, or a "Poison" marking with "PG III" or "PG III" beside a "Poison" label, may not be transported with foodstuffs, feed, or any other edible material, intended for consumption by humans or animals. For exceptions see §177.841(e) Source: United States Code of Federal Regulations, Title 49 CFR §177.848 - Segregation of hazardous materials. |||||||||||||||||||||||
  
  ## Packing groups
  
  Class 6 Packing Groups and Hazard Zones :
  
  | Group | Oral Toxicity $LD_{50}$ ${\tfrac {mg}{kg}}$ | Dermal Toxicity $LD_{50}$ ${\tfrac {mg}{kg}}$ | Inhalation Toxicity (Dust/Mist) $LC_{50}$ ${\tfrac {mg}{L}}$ |
  | - | - | - | - |
  | I | $\leq 5$ | $\leq 50$ | $\leq 0.2$ |
  | II | $>5$ but $\leq 50$ | $>50$ but $\leq 200$ | $>0.2$ but $\leq 2$ |
  | III | $>50$ but $\leq 300$ | $>200$ but $\leq 1000$ | $>2$ but $\leq 4$ |
  | Packing Group | Hazard Zone | Vapor Concentration and Toxicity |
  | I | A | $V\geq 500LC_{50}$; $LC_{50}\leq 200{\tfrac {mL}{m^{3}}}$. |
  | I | B | $V\geq 10LC_{50}$; $LC_{50}\leq 1000{\tfrac {mL}{m^{3}}}$ The criteria for Packing Group I. Hazard Zone A are not met. |
  | II | C | $V\geq LC_{50}$; $LC_{50}\leq 3000{\tfrac {mL}{m^{3}}}$ The criteria for Packing Group I, Hazard Zones A and B are not met. |
  | III | D | $V\geq .2LC_{50}$; $LC_{50}\leq 5000{\tfrac {mL}{m^{3}}}$ The criteria for Packing Groups I and II, Hazard Zones A, B and C are not met. |
  | Note 1: V is the saturated vapor concentration in air of the material in ${\tfrac {mL}{m^{3}}}$ at 20 °C and standard atmospheric pressure. Note 2: A liquid in Division 6.1 meeting criteria for Packing Group I, Hazard Zones A or B stated in paragraph (a)(2) of this section is a material poisonous by inhalation subject to the additional hazard communication requirements in 49CFR 172.203(m)(3), 49CFR 172.313 and Table 1 of 49CFR 172.504(e) of this subchapter. |||
  | Packing Group | Hazard Zone | Ratio of Volatility and $LC_{50}$ |
  | I | A | $R\geq 500$ and $LC_{50}(mixture)\leq 200{\tfrac {mL}{m^{3}}}$ |
  | I | B | $R\geq 10$ and $LC_{50}(mixture)\leq 1000{\tfrac {mL}{m^{3}}}$; and The criteria for Packing Group I, Hazard Zone A, are not met. |
  | II | C | $R\geq 1$ and $LC_{50}(mixture)\leq 3000{\tfrac {mL}{m^{3}}}$; and The criteria for Packing Group I, Hazard Zones A and B are not met. |
  | III | D | $R\geq {\tfrac {1}{5}}$ and $LC_{50}(mixture)\leq 5000{\tfrac {mL}{m^{3}}}$; and The criteria for Packing Groups I, Hazard Zones A, B and Packing Group II. |
  