title: Reticular pigmented anomaly of the flexures
text: # Reticular pigmented anomaly of the flexures
  
  Reticular pigmented anomaly of the flexures (also known as dark dot disease and Dowling–Degos disease) is a fibrous anomaly of the flexures or bending parts of the axillae, neck and inframammary/sternal $areas.^{:856}$ It is an autosomal-dominant pigmentary disorder that may appear in adolescence or adulthood. This condition is due to mutations in structural/desmosomal proteins found within stratified squamous epithelium.
  
  Dark dot disease is associated with KRT5.
  
  