title: DOV-216,303
text: # DOV-216,303
  
  DOV 216,303 is an experimental antidepressant drug originally developed by DOV Pharmaceutical and was licensed to Merck & Co. in 2004; Merck and DOV terminated their relationship in December $2006.^{:12}$
  
  It is a triple reuptake inhibitor (TRI), or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It is the racemic mixture of amitifadine (DOV-21,947) and its (–)-enantiomer, DOV-102,677. Its $IC_{50}$ values for SERT, NET, and DAT are $K_i$ 14 nM, 20 nM, and 78 nM, respectively.
  
  As of March 2008, DOV had no intention to further develop DOV-216,303 because the patent on the compound had $expired.^{:6}$
  
  In a mouse model, DOV-216,303 has shown the ability to promote recovery after spinal cord contusion.
  
  