title: TFCP2
text: # TFCP2
  
  Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.
  
  TFCP2 is also called Late SV40 factor (LSF) and it is induced by well known oncogene AEG-1. LSF also acts as an oncogene in hepatocellular carcinoma. LSF enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).
  
  Along with its main oncogene function in hepatocellular carcinoma (HCC) it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease. The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding to HCC DNA which results in HCC cell death.
  
  ## Interactions
  
  TFCP2 has been shown to interact with APBB1 and RNF2.
  
  