title: SIAH2
text: # SIAH2
  
  E3 ubiquitin-protein ligase SIAH2 is an enzyme that in humans is encoded by the SIAH2 gene.
  
  ## Function
  
  This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.
  
  ## Interactions
  
  SIAH2 has been shown to interact with PEG10, Synaptophysin, PEG3 and VAV1.
  
  