title: 6'-Guanidinonaltrindole
text: # 6'-Guanidinonaltrindole
  
  6′-Guanidinonaltrindole (6′-GNTI) is a κ–δ-opioid receptor selective ligand used in scientific research.
  
  With 6′-GNTI, evidence was provided for the first time that receptor oligomerization plays functional role in living organisms.
  
  6′-GNTI is an extremely biased agonist of the κ-opioid receptor. It is a potent partial agonist of the G protein pathway but does not recruit the β-arrestin pathway. Due to its functional selectivity for the G protein pathway, 6′-GNTI functions as an antagonist of nonbiased KOR agonists on the β-arrestin pathway. It is thought that 6′-GTNI may be able to produce analgesia without dysphoria and with a lower incidence of tolerance.
  
  