title: List of target antigens in pemphigoid
text: # List of target antigens in pemphigoid
  
  Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigoid.
  
  Target antigens for the different pemphigoid variants :
  
  | Pemphigoid variant | Antibody isotype | Antigen | Molecular weight (KDa) |
  | - | - | - | - |
  | Bullous pemphigoid | IgG, IgE | NC16A terminal of BPAG2 BPAG1 | 180 230 |
  | Gestational pemphigoid | IgG1 | NC16A terminal of BPAG2 BPAG1 | 180 230 |
  | Cicatricial pemphigoid | | C-terminal of BPAG2 | 180 |
  | Ocular cicatricial pemphigoid | | Integrin beta-4 subunit | 200 |
  | Antiepiligrin cicatricial pemphigoid | | Laminin 5 (Epiligrin, Laminin 332) | |
  | Linear IgA bullous dermatosis | | LAD1 portion of BPAG2 Collagen type VII | 97 290/145 |
  | Protein 105 pemphigoid | | Protein in lower lamina lucida | 105 |
  
  Of note, there are also several other diseases that are caused by auto-antibodies that target the same anatomic area of the skin which is termed the basement membrane zone. These diseases include:
  
  Target antigens for the different autoimmune bullous conditions targeting the basement membrane zone of the human integumentary system, excluding pemphigoid :
  
  | Disease | Antigen | Molecular weight (KDa) |
  | - | - | - |
  | Epidermolysis bullosa acquisita | Collagen type VII | 290/145 |
  | Bullous lupus erythematosus | Collagen type VII | 290/145 |
  | Lichen planus pemphigoides | BPAG2 | 180 |
  
  ## Footnotes
  
  * ↑ The antiepiligrin variant of cicatricial pemphigoid is associated with gastric cancer.
  * ↑ In this condition bullae develop on skin already affected by lesions of lichen planus as well as on areas of skin without lesions of lichen planus.
  