title: List of target antigens in pemphigus
text: # List of target antigens in pemphigus
  
  Circulating auto-antibodies in the human body can target normal parts of the skin leading to disease. This is a list of antigens in the skin that may become targets of circulating auto-antibodies leading to the various types of pemphigus.
  
  Target antigens for the different pemphigus variants :
  
  | Pemphigus variant | Antibody isotype | Antigen | Molecular weight (KDa) |
  | - | - | - | - |
  | Mucosal pemphigus vulgaris | IgG | Desmoglein 3 | 130 |
  | Mucocutaneous pemphigus vulgaris | IgG | Desmoglein 3 Desmoglein 1 | 130 160 |
  | Pemphigus foliaceus | IgG | Desmoglein 1 | 160 |
  | Paraneoplastic pemphigus | IgG | Desmoglein 3 Desmoglein 1 BPAG1 Plectin Desmoplakin I Desmoplakin II Envoplakin Periplakin Alpha-2-macroglobulin-like-1 | 130 160 230 500 250 210 210 190 170 |
  | Drug-induced pemphigus | IgG | Desmoglein 3 Desmoglein 1 | 130 160 |
  | Subcorneal pustular dermatosis type of IgA pemphigus | IgA1 | Desmocollin 1 | 110/100 |
  | Intraepidermal neutrophilic type of IgA pemphigus | IgA1 | Unknown | |
  | Pemphigus erythematosus (Senear–Usher syndrome) | IgG | Desmoglein 1 | 160 |
  | Fogo selvagem | IgG | Desmoglein 1 | 160 |
  | Pemphigus vegetans | IgG | Desmoglein 3 | 130 |
  | Pemphigus vegetans of Hallopeau | IgG | Desmoglein 3 | 130 |
  | Pemphigus vegetans of Neumann | IgG | Desmoglein 3 | 130 |
  | Pemphigus herpetiformis | IgG | Desmoglein 3 Desmoglein 1 | 130 160 |
  
  ## Footnotes
  
  * ↑ Notably not BPAG2
  * ↑ Desmoplakin I and II autoantibodies have also been reported in Stevens–Johnson syndrome
  * ↑ Parentheticals are used to indicate other names by which a condition is known. If there are multiple alternative names for a condition, they are separated by commas within the parenthetical.
  * 1 2 Pemphigus vegetans of Hallopeau represents a mild form of pemphigus vegetans. Pemphigus vegetans of Neumann represents a severe form of pemphigus vegetans.
  