title: ADCY10
text: # ADCY10
  
  Adenylyl cyclase 10 also known as ADCY10 is an enzyme that, in humans, is encoded by the ADCY10 gene.
  
  ## Function
  
  The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction.
  
  ## Clinical significance
  
  Mutations in the ADCY10 gene are associated with an increased risk of adsorptive hypercalciuria and male infertility.
  
  