title: COPE (gene)
text: # COPE (gene)
  
  Coatomer subunit epsilon is a protein that in humans is encoded by the COPE gene.
  
  ## Function
  
  The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
  
  ## Interactions
  
  COPE (gene) has been shown to interact with COPA.
  
  