title: Trimetrexate
text: # Trimetrexate
  
  Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor.
  
  ## Uses
  
  It has been used with leucovorin in treating pneumocystis pneumonia.
  
  It has been investigated for use in treating leiomyosarcoma. It is a methotrexate (MTX) analog that is active against transport-deficient MTX-resistant tumor cells that overcome the acquired and natural resistance to methotrexate. Other uses include skin lymphoma.
  
  