title: Adafenoxate
text: # Adafenoxate
  
  Adafenoxate is a compound related to centrophenoxine, that has been found to act as a nootropic in rats.
  
  ## Synthesis
  
  Ex 1: 4-Chlorophenoxyacetic acid (pCPA) [122-88-3] is converted to its acid chloride to give 4-chlorophenoxyacetyl chloride [4122-68-3] (1). Esterification with 2-(1-adamantylamino)ethanol [3716-66-3] (2) gives Adafenoxate (3) in a single step.
  
  Ex 2: Same as above but Fischer–Speier esterification done via a DS-trap. This gives an 88% yield.
  
  