title: 5F-ADB-PINACA
text: # 5F-ADB-PINACA
  
  5F-ADB-PINACA is a cannabinoid designer drug that is an ingredient in some synthetic cannabis products. It is a potent agonist of the $CB_1$ receptor and $CB_2$ receptor with $EC_{50}$ values of 0.24 nM and 2.1 nM respectively.
  
  ## Metabolism
  
  Twelve 5F-ADB-PINACA major metabolites were identified in several incubations with cryopreserved human hepatocytes. Major metabolic reactions included oxidative defluorination followed by carboxylation.
  
  ## Legality
  
  5F-ADB-PINACA is listed in the Fifth Schedule of the Misuse of Drugs Act (MDA) and therefore illegal in Singapore as of May 2015.
  
  