title: HU-308
text: # HU-308
  
  HU-308 (also known as onternabez, HU308, PPP-003 and ARDS-003) is a cannabidiol (CBD)-derivative drug that acts as a potent cannabinoid agonist. It is highly selective for the cannabinoid-2 receptor $(CB_2$ receptor) subtype, with a selectivity more than 5,000 times greater for the $CB_2$ receptor than the $CB_1$ receptor. The synthesis and characterization of HU-308 took place in the laboratory of Raphael Mechoulam at the Hebrew University of Jerusalem (the HU in HU-308) in the late 1990s. The pinene dimethoxy-DMH-CBD derivative HU-308 was identified as a potent peripheral $CB_2-selective$ agonist in in vitro and animal studies in 1990 and 1999.
  
  ## Legal status
  
  Tetra Bio-Pharma owns the intellectual property rights to HU-308.
  
  HU-308 is non-psychoactive and not scheduled at the federal level in the United States. It is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess there.
  
  