title: Goblet cell carcinoid
text: # Goblet cell carcinoid
  
  The goblet cell carcinoid (GCC) is a rare biphasic gastrointestinal tract tumour that consists of a neuroendocrine component and a conventional carcinoma, histologically arising from Paneth cells.
  
  ## Sign and symptoms
  
  GCCs may present as appendicitis.
  
  ## Diagnosis
  
  GCCs are diagnosed by pathology. They have a characteristic biphasic appearance which includes (1) goblet cell-like cells, and (2) neuroendocrine-type nuclear chromatin (stippled chromatin).
  
  ## Prognosis
  
  GCCs have an aggressive course compared to other appendiceal neuroendocrine tumours.
  
  ## Treatment
  
  GCCs are treated with surgery.
  
  