title: Zadik–Barak–Levin syndrome
text: # Zadik–Barak–Levin syndrome
  
  Zadik–Barak–Levin syndrome (ZBLS) is a congenital disorder in humans. Presenting conditions include primary hypothyroidism, cleft palate, hypodontia, and ectodermal dysplasia. It is the result of an embryonic defect in the mesodermal-ectodermal midline development.
  
  ## Signs and symptoms
  
  * anodontia/oligodontia—no teeth or fewer teeth than normal
  * cleft palate
  * depressed nasal bridge
  * dry skin
  * ectopic/agenesis/hypoplastic thyroid
  * epibulbar dermoid
  * frontal bossing
  * hypertelorism
  * hypothyroidy
  * lordosis
  * macroglossia
  * microcephaly
  * micrognatia/retrognatia—small or recessed jaw(s)
  * polyhydramnios
  * short stature/dwarfism
  * sparse/absent scalp hair(generalized)
  * squint/paresis of ocular muscles
  * umbilical hernia
  