title: 5-MeO-DET
text: # 5-MeO-DET
  
  5-MeO-DET or 5-methoxy-N,N-diethyltryptamine is a hallucinogenic tryptamine.
  
  ## Pharmacology
  
  5-MeO-DET inhibits serotonin reuptake with an $IC_{50}$ value of 2.4 μM and activates $5-HT_{2A}$ receptors with an $EC_{50}$ value of 8.11 nM.
  
  ## Effects
  
  Low dosages (0.5–1 mg) are reported to produce a relaxing body high and mild entheogenic effects. Shulgin reports in TiHKAL that higher dosages (1–3 mg) can produce very unpleasant reactions.
  
  