title: Neostigmine/glycopyrronium bromide
text: # Neostigmine/glycopyrronium bromide
  
  Neostigmine/glycopyrronium bromide, sold under the brand name Prevduo , is a fixed-dose combination medication used for the reversal of the effects of non-depolarizing neuromuscular blocking agents after surgery. It contains neostigmine as the methylsulfate, a cholinesterase inhibitor, and glycopyrronium bromide, an antimuscarinic agent.
  
  Neostigmine/glycopyrronium bromide was approved for medical use in the United Kingdom in 2007, and in the United States in February 2023.
  
  ## Medical uses
  
  Neostigmine/glycopyrronium bromide is indicated for the reversal of the effects of non-depolarizing neuromuscular blocking agents after surgery, while decreasing the peripheral muscarinic effects (e.g., bradycardia and excessive secretions) associated with cholinesterase inhibition following non-depolarizing neuromuscular blocking agent reversal administration.
  
  