title: CSNK1E
text: # CSNK1E
  
  Casein kinase I isoform epsilon is an enzyme that in humans is encoded by the CSNK1E gene.
  
  ## Function
  
  The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate proteins of the Period family of circadian rhythm proteins. A homolog of this mammalian protein can be found in Drosophila melanogaster. Known as doubletime, this protein also plays a role in the phosphorylation of proteins involved in circadian rhythms. Two transcript variants encoding the same protein have been found for this gene.
  
  ## Interactions
  
  CSNK1E has been shown to interact with PER1 and AXIN1.
  
  ## Inhibitors
  
  ### Selective
  
  * PF-4800567
  
  ### Non-selective
  
  * PF-670462 (also inhibits CK1-δ)
  