title: Propamocarb
text: # Propamocarb
  
  Propamocarb is a systemic fungicide used for control of soil, root and leaf disease caused by oomycetes. It is used by watering or spraying. Propamocarb is absorbed and distributed through the plant's tissue.
  
  ## Use
  
  Propamocarb has fungicidal activity only against oomycetes.
  
  ## Safety
  
  Propamocarb has low general toxicity, and almost no teratogenicity or neurotoxicity for mammals. It is not a carcinogen nor mutagen. Propamocarb is not susceptible to formation of resistant diseases. It is fully metabolized by plants and aquatic bacteria in a few weeks, so it is not a major ecological threat. It carries the risk of skin sensitization. Oral $LD_{50}$ is 2900 mg/kg for male rats and 2000 mg/kg for female rats.
  
  In one study conducted on tobacco, cucumber and spinach, using propamocarb synthesized out of carbon $C^{14}$ radionuclide, researchers stated that propamocarb is decomposed down to carbon dioxide and then incorporated into the plant's natural compounds, such as amino acids.
  
  