title: Azinomycin B
text: # Azinomycin B
  
  Azinomycin B is a natural product that contains densely assembled functionalities with potent antitumor activity. It is isolated from Streptomyces sahachiroi which is reisolated from S. griseofuscus along with its analog azinomycin A. Azinomycin B can bind within the major groove of DNA and forms covalent interstrand crosslinks (ISCs) with the purine bases. The DNA alkylation and crosslinking by azinomycin B suggests its potent antitumor activity.
  
  ## Biosynthesis
  
  The biosynthesis of azinomycin B includes a type 1 polyketide synthase and several nonribosomal peptide synthetases.
  
  