title: 2,4,5-Trihydroxyamphetamine
text: # 2,4,5-Trihydroxyamphetamine
  
  2,4,5-Trihydroxyamphetamine (THM) is a neurotoxin and a metabolite of MDMA. It comes from the ring-hydroxylation of 3,4-methylenedioxyamphetamine (MDA).
  
  In one paper, it was shown to reduce hippocampal tryptophan hydroxylase activity by 54% after short-term treatment. In another study, it was shown to significantly reduce striatal tyrosine hydroxylase activity.
  
  