title: WDR37
text: # WDR37
  
  WD repeat-containing protein 37 is a protein that in humans is encoded by the WDR37 gene.
  
  This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.
  
  ## Clinical
  
  Mutations in this gene have been linked to a number of lesions in humans. These include
  
  * Corneal opacity/Peters anomaly
  * Coloboma
  * Microcornea
  * Cerebellar hypoplasia
  * Epilepsy
  * Dysmorphic facial features
  * Variable skeletal, cardiac and genitourinary defects
  * Significant neurological impairment with structural brain defects and seizures
  * Poor feeding
  * Poor post-natal growth
  * Death in infancy
  