title: Van Den Bosch syndrome
text: # Van Den Bosch syndrome
  
  van Den Bosch syndrome is a rare X-linked syndrome like intellectual disability. It may be caused by a small X-chromosome deletion.
  
  The condition can be detected around $infancy.^{:1067}$
  
  ## Epidemiology
  
  According to Orphanet the condition occurs in 1 in 1 million people.
  
  It has been reported in only one family.
  
  ## Symptoms
  
  Symptoms for the condition include.
  
  * Abnormal electroretinogram
  * Acrokeratosis
  * Anhidrotic ectodermal dysplasia
  * Choroideremia
  * Heat intolerance
  * High myopia
  * Horizontal nystagmus
  * Intellectual disability
  * Recurrent respiratory infections
  * Recurrent skin infections
  * Scapular winging
  * Unfavorable response of muscle weakness to acetylcholine esterase inhibitors
  * skeletal abnormality
  * Anhidrosis
  * Contiguous gene syndrome
  * X-linked inheritance
  
  ## History
  
  It was first described by J. Van den Bosch in 1959. He reported the condition in 2 brothers. The condition was found in more males spanning three generations. According to Orphanet there have been no more descriptions in literature since 1959.
  
  