title: SB-649,915
text: # SB-649,915
  
  SB-649,915 is a serotonin reuptake inhibitor and $5-HT_{1A}$ and $5-HT_{1B}$ receptor antagonist which is being investigated for its antidepressant effects. Relative to the selective serotonin reuptake inhibitors (SSRIs), SB-649,915 has a faster onset of action and may also have greater clinical efficacy as well. This can be attributed to blockade of $5-HT_{1A}$ and $5-HT_{1B}$ autoreceptors which inhibit serotonin release.
  
  