title: P21-activated kinases
text: # P21-activated kinases
  
  p21 activated kinases (PAKs) are members of a family of enzymes. They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological activities.
  
  Members include:
  
  * PAK1, regulating cell motility and morphology
  * PAK2, possibly playing a role in apoptosis
  * PAK3, possibly for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity
  * PAK4, a mediator of filopodia formation
  * PAK5, a mediator of filopodia formation
  * PAK6, involved in cytoskeleton rearrangement
  