title: Thienopyridine
text: # Thienopyridine
  
  Thienopyridines are a class of selective, irreversible ADP receptor/P2Y12 inhibitors used for their anti-platelet activity. They have a significant role in the management of cardiovascular disease.
  
  ## Clinical Uses
  
  They are used in the management of peripheral artery disease, as well as the prevention of coronary stent thrombosis and strokes.
  
  ## Examples
  
  Drugs in this class include: clopidogrel (Plavix), prasugrel (Effient), and ticlopidine (Ticlid).
  
  Tinoridine was actually a predecessor to this work.
  
  ## Alternatives
  
  Ticagrelor (Brilinta) is often listed with thienopyridine inhibitors and has similar indications for use but is not a thienopyridine. It is a cyclo-pentyltriazolo-pyrimidine that is distinct from the mechanism of the thienopyridines in that it reversibly (rather than irreversibly) inhibits the $P2Y_{12}$ receptor.
  
  