title: Phenylpiperidines
text: # Phenylpiperidines
  
  Phenylpiperidines are chemical compounds with a phenyl moiety directly attached to piperidine. There are a variety of pharmacological effects associated with phenylpiperidines including morphine-like activity or other central nervous system effects.
  
  "Phenyl"piperidines :
  
  | Compound | N | 4-position | 3-position | 4'-position | Type of pharmacology |
  | - | - | - | - | - | - |
  | MPPP | Me | Ph | H | –OCOEt | Opioid analgesic |
  | Prodine | Me | Ph | Me | –OCOEt | Opioid analgesic |
  | PEPAP | $CH_2CH_2Ph$ | Ph | H | –OCOMe | Opioid analgesic |
  | Pethidine | Me | Ph | H | $–CO_2Et$ | mu-Agonist with serotonin reuptake inhibitor properties |
  | Budipine | t-Bu | Ph | H | Ph | Antiparkinson agent |
  | Ketobemidone | Me | 3-HO–Ph | H | –COEt | Opioid and NMDA antagonist |
  | Paroxetine | H | 4-F–Ph | $–CH_2OAr$ | H | Selective serotonin reuptake inhibitor (and norepinephrine transporter) |
  | Femoxetine | Me | Ph | $–CH_2O(4-MeOPh)$ | H | Selective serotonin reuptake inhibitor |
  | CPCA | Me | 4-Cl–Ph | $–CO_2Me$ | H | Monoamine reuptake inhibitor |
  
  Methylphenidate is a benzylpiperidine.
  
  