title: Methoxy arachidonyl fluorophosphonate
text: # Methoxy arachidonyl fluorophosphonate
  
  Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty acid amide hydrolase with special potency, displaying $IC_{50}$ values in the low-nanomolar range. In addition, it binds to the $CB_1$ receptor in rat brain membrane preparations $(IC_{50}$ = 20 nM), but does not appear to agonize or antagonize the receptor, though some related derivatives do show cannabinoid-like properties.
  
  