title: SELS (gene)
text: # SELS (gene)
  
  Selenoprotein S, also known as SELS, is a human gene.
  
  This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
  
  ## Interactions
  
  SELS (gene) has been shown to interact with Valosin-containing protein.
  
  