Of course, I have a powerful imagination. A few questions:

1) How rigorous do you want your RPG?
2) What's interesting to you?

Without knowing, I suggest:

1) RustWorld - Play a post apocalyptic thrift shopper in a steampunk city
2) AquaTerra2 - Dive into a subterranean world of caves as a spelunker
3) MoonBase 20XX - Play a NASA astronaut working to build the first permanent research station on the moon
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