Considering the patient's obesity and osteoarthritis of the hand, which medication is most appropriate for managing their chronic pain while minimizing the risk of gastrointestinal side effects?
Tramadol hydrochloride 50 MG Oral Tablet Oxycodone Hydrochloride 10 MG Extended Release Oral Tablet [Oxycontin] Vancomycin 5 MG/ML Injection Naproxen sodium 220 MG Oral Tablet