A patient with hypertension is being treated with amlodipine, lisinopril, and hydrochlorothiazide. Given this medication regimen and the patient's reported pain severity and social isolation, which symptom progression should be most closely monitored?
Worsening hypertension due to non-compliance with medication. Progression of renal impairment due to long-term use of lisinopril. Increased risk of electrolyte imbalance due to hydrochlorothiazide use. Potential development of depressive symptoms due to social isolation and chronic condition management.