Considering the patient's current medications and medical conditions, which of the following is the most significant health risk that requires immediate monitoring?
Risk of opioid dependency due to the use of extended-release oxycodone. Increased risk of gastrointestinal bleeding due to NSAID use in a patient with obesity and osteoarthritis. Increased cardiovascular risk due to high BMI and use of naproxen. Potential nephrotoxicity from concurrent use of vancomycin and piperacillin-tazobactam.