Considering the patient's current medications for hypertension, how do amlodipine and lisinopril work together to manage blood pressure?
Amlodipine and lisinopril both act directly on the heart to decrease cardiac output, thereby reducing blood pressure. Amlodipine increases renal blood flow, and lisinopril enhances potassium excretion, leading to a synergistic blood pressure reduction. Amlodipine reduces heart rate, and lisinopril increases sodium excretion, together lowering blood pressure effectively. Amlodipine causes vasodilation by blocking calcium channels, while lisinopril reduces blood pressure by inhibiting angiotensin-converting enzyme (ACE), leading to decreased vasoconstriction and fluid retention.