Given the patient's history of hypertension and current medications, which of the following describes the most appropriate mechanism by which lisinopril and leuprolide acetate could affect blood pressure regulation together?
Lisinopril directly increases the renal clearance of leuprolide acetate, enhancing its antihypertensive effects. Lisinopril reduces angiotensin II production, and leuprolide acetate, by reducing testosterone levels, may indirectly decrease sympathetic nervous system activity, potentially aiding in blood pressure control. Lisinopril and leuprolide acetate both inhibit the same enzyme, leading to synergistic blood pressure reduction. Leuprolide acetate acts as a direct vasodilator, complementing the vasodilatory effects of lisinopril.