Considering the patient's current medication regimen, which pharmacokinetic interaction is most likely to affect the efficacy of simvastatin, potentially leading to increased risk of adverse effects?
Simvastatin metabolism is enhanced by Acetaminophen via CYP3A4 interaction. Simvastatin clearance is increased by Amoxicillin via renal excretion enhancement. Simvastatin metabolism is inhibited by Naproxen via CYP2C9 interaction. Simvastatin absorption is reduced by Alendronic acid when taken simultaneously.