Considering the patient's medication regimen and conditions, which of the following mechanisms best explains the potential impact of combining acetaminophen with opioids like codeine and oxycodone in managing pain for a patient with a history of intimate partner abuse and limited social contact?
The combination of acetaminophen with opioids is contraindicated in patients with obesity due to increased risk of cardiovascular events. The combination of acetaminophen with opioids can provide synergistic analgesic effects, potentially reducing the need for higher opioid doses and minimizing the risk of opioid misuse in vulnerable populations. The combination of acetaminophen with opioids leads to reduced efficacy of the opioid component, potentially necessitating higher doses for adequate pain control. The combination of acetaminophen with opioids increases the risk of hepatic toxicity due to acetaminophen's metabolism, necessitating careful monitoring of liver function.