In a patient with hypertension, obesity, and dyslipidemia, who is currently taking lisinopril, simvastatin, and naproxen, which of the following mechanisms best explains how their medications work together to manage their conditions?
Lisinopril reduces blood pressure by inhibiting the renin-angiotensin system, simvastatin lowers LDL cholesterol, and naproxen provides anti-inflammatory effects that can reduce obesity-related inflammation. Lisinopril directly lowers cholesterol levels, simvastatin reduces blood pressure, and naproxen enhances the effect of statins by inhibiting prostaglandin synthesis. Lisinopril and simvastatin both work by inhibiting the renin-angiotensin system and naproxen enhances this effect by reducing systemic inflammation. Lisinopril lowers blood pressure by increasing sodium excretion, simvastatin increases HDL cholesterol, and naproxen reduces LDL cholesterol by reducing liver synthesis.