A patient with chronic sinusitis and hypertension is being treated with amoxicillin/clavulanate, hydrochlorothiazide, lisinopril, and amlodipine. Considering their current treatment and conditions, which factor is most likely to influence the progression of their chronic sinusitis over time?
Uncontrolled hypertension exacerbating sinus pressure Use of hydrochlorothiazide leading to dehydration and worsening sinusitis The anti-inflammatory effects of naproxen improving sinusitis symptoms Potential development of antibiotic resistance due to repeated courses of antibiotics