A patient with chronic sinusitis and a BMI of 30.2 kg/m² reports a pain severity score of 2/10 and is currently taking clopidogrel, simvastatin, and amlodipine. Considering the patient's medication regimen and clinical findings, which potential complication should be most closely monitored?
Increased risk of gastrointestinal bleeding Exacerbation of hypertension Development of rhinitis medicamentosa Decreased efficacy of statin therapy