Given the patient's medical conditions and current medication regimen, what is the most significant health risk associated with the combination of hypertension and chronic sinusitis?
Increased risk of renal impairment due to hypertension medication. Increased risk of osteoporosis due to chronic use of ibuprofen and vitamin B12 supplementation. Increased risk of cardiovascular events due to uncontrolled hypertension and potential respiratory complications. Increased risk of acute liver failure due to potential drug interactions.