A patient with hypertension is on hydrochlorothiazide and reports severe pain managed with naproxen and oxycodone-acetaminophen. Given the patient's medications and clinical context, what is the most likely reason for advising caution with the use of naproxen?
Naproxen can cause increased blood pressure, counteracting the effects of hydrochlorothiazide. Naproxen is contraindicated in patients receiving amoxicillin/clavulanate. Naproxen can cause severe hypokalemia when used with hydrochlorothiazide. Naproxen can reduce the effectiveness of tramadol.