Given the patient's elevated creatinine level and current medication regimen, which pharmacokinetic interaction is most likely to exacerbate renal function impairment?
Ibuprofen's inhibition of renal prostaglandin synthesis Acetaminophen metabolism by GSTM1 affecting liver function Hydrocodone's metabolism by CYP2D6 leading to increased analgesic effect Simvastatin metabolism by CYP3A4 leading to increased plasma levels