Considering the patient's chronic sinusitis, hypertension, and current medication regimen, which of the following is the most significant risk factor for developing complications related to uncontrolled hypertension?
Non-adherence to antihypertensive medications Chronic sinusitis leading to systemic inflammation Use of Naproxen sodium, a nonsteroidal anti-inflammatory drug Obesity due to a BMI of 28.2 kg/m2