Considering the medications prescribed to the patient with hypertension and significant pain, what is the most likely interaction between hydrochlorothiazide and naproxen that could affect the patient's condition?
Hydrochlorothiazide decreases the analgesic effect of naproxen by altering its metabolism. Naproxen enhances the diuretic effect of hydrochlorothiazide by increasing renal blood flow. Naproxen and hydrochlorothiazide together increase the risk of hyperkalemia. Naproxen may reduce the antihypertensive effect of hydrochlorothiazide due to sodium retention.