Given the patient's current medications and clinical data, which potential pharmacokinetic interaction should be considered between Simvastatin and Naproxen, and how might this affect the patient's renal function?
Naproxen induces CYP3A4, potentially decreasing the effectiveness of Simvastatin. Simvastatin is known to increase the renal clearance of Naproxen, reducing its anti-inflammatory effects. Simvastatin and Naproxen both compete for the same CYP enzyme, leading to increased plasma levels of Simvastatin. Simvastatin is metabolized by CYP3A4, and Naproxen can inhibit renal prostaglandins, potentially exacerbating renal impairment due to elevated creatinine levels.