Given the patient's use of multiple hormonal contraceptives and acetaminophen, which of the following mechanisms best explains how these treatments might interact to affect liver function?
Hormonal contraceptives reduce the analgesic effect of acetaminophen by increasing its elimination. Acetaminophen enhances the effectiveness of hormonal contraceptives by inhibiting their metabolism. Both hormonal contraceptives and acetaminophen are metabolized by the liver, potentially increasing hepatotoxicity risk. The combination of acetaminophen and hormonal contraceptives enhances the risk of renal toxicity.