    Sentence 1: What isa protein. that is closely  intertwined with circadian rhythms?    Sentence. 2: Additionally, proteins, such as. NFIL3,  which have been shown to be closely intertwined  with. both T-cell, differentiation. and our circadian  rhythms, can be affected through the disturbance of  natural light and. dark cycles through instances of  sleep deprivation, shift work, ete.