    Sentence r. What other business diftrict does Orange  County envelop outside of Downtown Santa Ana and  Newport Center?    Sentence 2: Orange County is a rapidly developing  business center that includes Downtown Santa Ana, the  South Conf Metro and Newport Center diftriés, as  swell as the Wvine business centers of The \rvine|  Specirum, Wel Irvine, and international corforations  headquartered at the University of California, irvine.